Delayed Puberty malady

Wikipedia: Puberty is described as delayed puberty with exceptions when an organism has passed the usual age of...⁴⁴ more...

MalaCards: Delayed Puberty, also known as puberty delayed, is related to beta thalassemia and anosmia. An important gene associated with Delayed Puberty is FSHB (follicle stimulating hormone, beta polypeptide), and among its related pathways are Aldosterone-regulated sodium reabsorption and GnRH signaling pathway. The drugs methyltestosterone pwdr [va product] and gonadorelin and the compounds ganirelix and bromocriptine have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are renal/urinary system and limbs/digits/tail.

delayed puberty 8 43 puberty delayed 32

Diseases related to delayed puberty by text searches and GeneDecks gene sharing:

(show top 50)    (show all 297)

id	Related Disease	Score	Top Affiliating Genes
1	beta thalassemia	28.8	LEP, CGA, IGF1, GNRH1, SHBG
2	anosmia	28.5	CHD7, KAL1, FGFR1, GNRHR
3	laron syndrome	28.3	IGF1, GH1, LSL
4	thalassemia	28.1	LEP, CGA, IGF1, GNRH1, GH1, SHBG
5	kallmann syndrome	27.4	KISS1, KISS1R, LEP, CHD7, CGA, CGB5
6	scoliosis	27.2	LEP, CHD7, IGF1, GNRH1, GH1
7	gigantism	27.0	IGF1, GH1, CYP17A1, PRL, POU1F1
8	gonadotropin deficiency	25.4	KISS1R, CGA, KAL1, FSHR, FGFR1, GNRH1
9	hypogonadotropism	25.3	KISS1, KISS1R, BRD2, LEP, CHD7, CGA
10	short stature	24.4	REN, LHX4, LEP, IHH, IGF1, GNRH1
11	hypogonadism	23.1	KISS1, KISS1R, BRD2, LEP, CHD7, CGA
12	amenorrhea	22.8	BRD2, LEP, CGA, FSHB, FSHR, IGF1
13	insulin resistance	22.2	REN, KISS1, LEP, CGA, CGB5, IGF1
14	hypertension	19.1	REN, KISS1, KISS1R, SCNN1A, SCNN1B, LEP
15	leydig cell adenoma	13.6	CGA, GNRH1
16	pseudohypoaldosteronism type i	13.6	SCNN1A, SCNN1B
17	borjeson-forssman-lehmann syndrome	13.5	LHX4, HESX1, PROP1, POU1F1
18	placental site trophoblastic tumor	13.4	CGA, CGB5
19	gestational trophoblastic neoplasm	13.4	KISS1, CGA, CGB5
20	5-alpha reductase deficiency	13.4	CGA, CGB5
21	kallmann syndrome 1	13.4	KAL1, FGFR1
22	sycp3-related pregnancy loss, susceptibility to	13.4	CGA, CGB5, GNRH1
23	growth hormone deficient dwarfism	13.4	GH1, POU1F1
24	primary ciliary dyskinesia	13.3	CGA, CYP19A1
25	aromatase excess syndrome	13.3	CGB5, CYP19A1
26	testotoxicosis	13.2	FSHR, CYP19A1
27	21-hydroxylase deficiency	13.2	BRD2, GNRH1, CYP11A1, CYP17A1
28	precocious puberty, male	13.2	FSHR, CYP19A1
29	micropenis	13.2	CGA, CGB5, GNRH1, CYP17A1
30	klinefelter's syndrome	13.2	KISS1R, CHD7, FGFR1, GNRHR
31	septooptic dysplasia	13.2	GH1, HESX1, PROP1, POU1F1
32	sexual disorder	13.1	GNRH1, PRL
33	neonatal thyrotoxicosis	13.1	TRH, PROP1
34	generalized resistance to thyroid hormone	13.1	TRH, PRL
35	ovarian cyst	13.0	CGA, CGB5, GNRH1, CYP19A1
36	complete androgen insensitivity syndrome	13.0	CYP19A1, SHBG
37	germ cell cancer	13.0	BRD2, CGA, IGF1
38	tooth agenesis	13.0	CHD7, KAL1, FGFR1
39	holoprosencephaly	13.0	LHX4, ESX1, HESX1, PROP1, POU1F1, NPY
40	antley-bixler syndrome	13.0	FGFR1, CYP17A1, CYP19A1
41	androgen insensitivity syndrome, partial	13.0	CYP19A1, SHBG
42	endogenous depression	13.0	GNRH1, TRH, PRL
43	achondroplasia	13.0	FGFR1, IHH, IGF1
44	aromatase deficiency	13.0	GNRH1, GH1, CYP19A1
45	sertoli-leydig cell tumor	13.0	FSHR, CYP17A1, CYP19A1
46	marasmus	13.0	GH1, SHBG, LSL
47	large cell carcinoma	13.0	CGA, CGB5, IGF1
48	laron dwarfism	13.0	IGF1, GH1
49	anophthalmia	13.0	LHX4, HESX1, PRL, POU1F1
50	anorchia	12.9	CGA, CGB5

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 gonadorelin, gonadorelin acetate, gonadorelin hydrochloride, methyltestosterone, methyltestosterone pwdr [va product], testosterone, testosterone cypionate, testosterone enanthate, testosterone propionate, testosterone propionate pwdr [va product], testosterone pwdr [va product]

MalaCards organs/tissues related to delayed puberty:

²²

MGI Mouse Phenotypes related to delayed puberty:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	9.2	SCNN1B, GNRH1, REN, KISS1, KISS1R, FGFR1
2	limbs/digits/tail phenotype	MP:0005371	8.4	LEP, TBX3, IHH, FGFR1, CHD7, FSHR
3	integument phenotype	MP:0010771	8.1	KISS1, KISS1R, FSHR, FGFR1, TBX3, PRL
4	digestive/alimentary phenotype	MP:0005381	8.0	FGFR1, IHH, KISS1R, GNRH1, GNRHR, CHD7
5	respiratory system phenotype	MP:0005388	7.9	PROP1, HESX1, IGF1, IHH, CHD7, LEP
6	skeleton phenotype	MP:0005390	7.7	GNRH1, FGFR1, CHD7, CYP19A1, IGF1, TBX3
7	embryogenesis phenotype	MP:0005380	7.5	BRD2, HESX1, LEP, CHD7, FGFR1, PRL
8	liver/biliary system phenotype	MP:0005370	7.3	PRL, NPY, KISS1, KISS1R, CYP19A1, LEP
9	normal phenotype	MP:0002873	7.3	KISS1R, SCNN1A, FGFR1, IGF1, SCNN1B, GNRH1
10	adipose tissue phenotype	MP:0005375	7.2	IGF1, FSHR, CHD7, LEP, GH1, CYP19A1
11	mortality/aging	MP:0010768	6.7	CYP11A1, CYP17A1, HESX1, PROP1, POU1F1, LHX4
12	reproductive system phenotype	MP:0005389	6.3	GH1, GNRHR, TBX3, CYP11A1, PRL, POU1F1
13	cardiovascular system phenotype	MP:0005385	6.3	CHD7, IHH, IGF1, ESX1, CYP19A1, FSHR
14	behavior/neurological phenotype	MP:0005386	5.9	FGFR1, PROP1, PRL, CYP19A1, REN, KISS1R
15	immune system phenotype	MP:0005387	5.7	FSHR, IGF1, BRD2, CHD7, LEP, REN
16	endocrine/exocrine gland phenotype	MP:0005379	4.5	KISS1, IHH, FGFR1, FSHR, CGA, CHD7
17	growth/size phenotype	MP:0005378	4.4	CGA, TRH, GH1, ESX1, GNRHR, GNRH1
18	nervous system phenotype	MP:0003631	4.4	CYP19A1, NPY, CHD7, FSHR, FGFR1, IHH
19	homeostasis/metabolism phenotype	MP:0005376	3.7	BRD2, KISS1R, KISS1, REN, CYP19A1, PRL

Articles related to delayed puberty:

(show all 29)

id	Title	Authors	Year	Affiliating Genes
1	Delayed puberty due to a novel mutation in CHD7 causi ng CHARGE syndrome. (21041284)	Dauber A.... Milunsky A.	2010	CHD7
2	Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system. (19228890)	Pinilla L.... Aguilar E.	2009	CYP11A1, GNRH1, KISS1R
3	Body composition and concentrations of leptin, neuropeptide Y, beta-endorphin, growth hormone, insulin-like growth factor-I and insulin at menarche in girls with constitutional delay of puberty. (16785149)	Bl/ogowska A.... Rzepka-Gorska I.	2006	IGF1, NPY
4	Isolated 17,20-lyase (desmolase) deficiency in a 46,XX female presenting with delayed puberty. (15866602)	Simsek E.... Achermann J.C.	2005	CYP17A1, CGA
5	Sex features at menarche in relation to gonadotropin, estradiol and sex hormone-binding globulin concentrations in girls with constitutional delay of puberty. Preliminary report. (16019372)	BA8ogowska A.... ZA^A8towski S.	2005	SHBG
6	Human chorionic gonadotropin therapy in adolescent boys with constitutional delayed puberty vs those with beta-thalassemia major. (15562375)	Soliman A.T.... El Matary W.	2005	CGA
7	Constitutional delayed puberty in males and hypogonadotropic hypogonadism: a reliable and cost-effective approach to differential diagnosis. (16279369)	Martin M.M.... Martin A.L.	2005	CGA, GNRH1
8	Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene. (15613419)	Pitteloud N.... Crowley W.F.	2005	FGFR1
9	Increase of serum leptin after short-term pulsatile GnRH administration in children with delayed puberty. (15132726)	Grasemann C.... Hauffa B.P.	2004	LEP, GNRH1, LSL
10	Is neuropeptide Y responsible for constitutional delay of puberty in girls? A preliminary report. (15625769)	Bl/ogowska A.... Krzyzanowska-Swiniarska B.	2004	NPY
11	The human chorionic gonadotropin test is more powerful than the gonadotropin-releasing hormone agonist test to discriminate male isolated hypogonadotropic hypogonadism from constitutional delayed puberty. (12824862)	Degros V.... Dewailly D.	2003	CGB5
12	Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies. (12915623)	Meduri G.... Misrahi M.	2003	FSHR
13	The NOTOM hypothesis for idiopathic scoliosis: is it nullified by the delayed puberty of female rhythmic gymnasts and ballet dancers with scoliosis? (15457686)	Burwell R.G.... Dangerfield P.H.	2002	GNRH1
14	A practical GnRH analogue (triptorelin) stimulation t est to distinguish constitutional delay of puberty from hypogonadotropic hypogo nadism in prepubertal boys. (11432487)	Ozkan B.... Bilginturan N.	2001	GNRH1
15	Dihydrotestosterone treatment in adolescents with delayed puberty: does it explain insulin resistance of puberty? (11600557)	Saad R.J.... Arslanian S.A.	2001	GH1
16	A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomised controlled trial. (11403810)	Wickman S.... Dunkel L.	2001	CYP19A1
17	Use of a specific aromatase inhibitor in delayed puberty. (11403802)	Stanhope R.	2001	CYP19A1
18	Spontaneous and GnRH-provoked gonadotropin secretion and testosterone response to human chorionic gonadotropin in adolescent boys wi th thalassaemia major and delayed puberty. (10822933)	Soliman A.T.... Ansari B.M.	2000	CGA, GNRH1
19	Serum leptin levels in males with delayed puberty during short-term pulsatile GnRH administration. (10090130)	Giusti M.... Giordano G.	1999	LEP, LSL
20	Delayed puberty and hypogonadism caused by mutations in the follicle- stimulating hormone beta-subunit gene. (9271483)	Layman L.C.... Jameson J.L.	1997	FSHB
21	Testosterone treatment in adolescents with delayed puberty: changes in body composition, protein, fat, and glucose metabolism. (9329341)	Arslanian S.... Suprasongsin C.	1997	LEP
22	Delayed puberty and hypogonadotrophic hypogonadism: differential diagnosis with prolactin stimulation probe with chlorpromazine (8733264)	Torrealba I.M.... Beas L F.	1995	PRL
23	Increased nocturnal melatonin secretion in male patients with hypogonadotropic hypogonadism and delayed puberty. (7608268)	Luboshitzky R.... Lavie P.	1995	PRL
24	Delayed puberty in males with beta-thalassemia major: pulsatile gonadotropin-releasing hormone administration induces changes in gonadotropin isoform profiles and an increase in sex steroids. (7627337)	Valenti S.... Dahl K.D.	1995	GNRH1
25	The role of TRH-stimulated prolactin responses in distinguishing gonadotropin deficiency from constitutional delayed puberty. (7735370)	BA1yA1kgebiz A.... Oktay S.	1994	PRL, GNRH1
26	Successful treatment of short stature and delayed puberty in congenital magnesium-losing kidney. (8250506)	Taylor A.J.... Dornan T.L.	1993	REN
27	Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty. (8473416)	Keenan B.S.... Smith E.R.	1993	IGF1
28	LH measurements by in vitro bioassay and a highly sensitive immunofluorometric assay improve the distinction between boys with constitutional delay of puberty and hypogonadotropic hypogonadism. (2181393)	Haavisto A.M.... Huhtaniemi I.	1990	GNRH1
29	An evaluation of human chorionic gonadotrophin (HCG) therapy in boys with delayed puberty. (2385733)	Gordon D.... Thomson J.A.	1990	CGA

Genes related to delayed puberty according to GeneCards:

(show all 34)

id	Symbol	Description	Score	GeneCards Section Context
1	FSHB	follicle stimulating hormone, beta polypeptide	11.0	Publications
2	ESX1	ESX homeobox 1	11.0
3	KISS1R	KISS1 receptor	11.0	Publications
4	IHH	Indian hedgehog	11.0
5	TBX3	T-box 3	11.0
6	HESX1	HESX homeobox 1	11.0
7	KISS1	KiSS-1 metastasis-suppressor	11.0	Publications
8	LHX4	LIM homeobox 4	11.0
9	PROP1	PROP paired-like homeobox 1	11.0
10	SCNN1B	sodium channel, non-voltage-gated 1, beta subunit	11.0
11	POU1F1	POU class 1 homeobox 1	11.0
12	SCNN1A	sodium channel, non-voltage-gated 1 alpha subunit	11.0
13	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
14	CUL4B	cullin 4B	11.0
15	GNRHR	gonadotropin-releasing hormone receptor	11.0
16	LSL	Leptin, serum levels of	11.0	Publications
17	BRD2	bromodomain containing 2	11.0
18	TRH	thyrotropin-releasing hormone	11.0
19	CYP11A1	cytochrome P450, family 11, subfamily A, polypeptide 1	11.0	Publications
20	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
21	SHBG	sex hormone-binding globulin	11.0	Publications
22	NPY	neuropeptide Y	11.0	Publications
23	KAL1	Kallmann syndrome 1 sequence	11.0
24	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0	Publications
25	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
26	FSHR	follicle stimulating hormone receptor	11.0	Publications
27	CHD7	chromodomain helicase DNA binding protein 7	11.0	Publications
28	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
29	GH1	growth hormone 1	11.0	Publications
30	REN	renin	11.0	Publications
31	PRL	prolactin	11.0	Publications
32	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
33	LEP	leptin	11.0	Publications
34	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications

Pathways related to delayed puberty according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Aldosterone-regulated sodium reabsorption20	9.9	SCNN1A, SCNN1B
2	GnRH signaling pathway20	9.8	CGA, FSHB, GNRH1, GNRHR
3	G alpha (q) signalling events38	9.8	GNRH1, GNRHR, TRH, KISS1, KISS1R
4	Development Role of Activin A in cell differentiation and proliferation10	9.6	FSHB, CGA, FSHR, GNRHR, CYP11A1
5	Development_Role of Activin A in cell differentiation and proliferation41	9.6	FSHB, FSHR, CYP11A1, CGA, GNRHR
6	Selected targets of GCR-alpha10	9.2	SCNN1A, FSHB, LEP, CGA
7	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.1	CGA, CYP19A1, IGF1
8	Renin-Angiotensin Pathway36	8.5	REN, FGFR1, GNRH1, IGF1, GH1
9	Neuroactive ligand-receptor interaction20	7.9	FSHB, GNRHR, FSHR, PRL, CGA, LEP

Compounds related to delayed puberty according to GeneDecks:

(show top 50)    (show all 175)

id	Compound	Score	Top Affiliating Genes
1	ganirelix32	9.9	GNRH1, FSHB, GNRHR, CGA
2	bromocriptine32 9 9	11.3	POU1F1, PRL, TRH, GH1, GNRHR, GNRH1
3	goserelin32 9 9	11.2	CGA, GNRH1, CYP19A1, SHBG, LSL, GNRHR
4	sodium nitroprusside32	9.2	NPY, CGB5, REN, CGA
5	11 deoxycortisol32	8.9	CGA, REN, CYP17A1, SHBG, PRL
6	estradiol benzoate32	8.8	CYP19A1, GNRH1, CGB5, CGA, PRL
7	leuprolide32 42 9 9	11.7	PRL, LSL, GNRHR, GNRH1, IGF1, CGB5
8	dopamine32 9 18 9	11.6	CGB5, CGA, GH1, GNRH1, REN, TRH
9	metoclopramide32 9 9	10.6	PRL, CGA, CYP17A1, GNRH1, GH1, TRH
10	diethylstilbestrol32 9 9	10.6	GNRH1, SHBG, CYP19A1, CYP17A1, CGA, CGB5
11	cetrorelix32 9 9	10.5	IGF1, GNRHR, GNRH1, CGB5, CGA, LEP
12	octreotide32 42 9 9	11.4	NPY, TRH, IGF1, GNRH1, GH1, LSL
13	raloxifene32 9 9	10.4	SHBG, IGF1, GNRH1, GH1, LSL, CYP19A1
14	valproate32	8.4	LSL, PRL, IGF1, CYP11A1, CYP17A1, SHBG
15	sulpiride32 9 9	10.2	CGB5, LEP, NPY, GH1, PRL, TRH
16	buserelin32 9 9	10.2	PRL, CYP19A1, GNRHR, GNRH1, IGF1, FSHB
17	naloxone32 34 9 9	11.0	GNRH1, PRL, GH1, TRH, CGA, LEP
18	11beta-hydroxysteroid32	8.0	REN, LEP, CGB5, GH1, CYP11A1, CYP17A1
19	17-hydroxyprogesterone32 18	8.8	PRL, SHBG, CYP19A1, CYP17A1, CYP11A1, GNRH1
20	letrozole32 42 9 9	10.7	IGF1, LEP, CYP19A1, SHBG, CGA
21	clomiphene citrate32	7.7	CGB5, CGA, FSHB, IGF1, PRL, SHBG
22	adenylate32	7.7	GNRHR, TRH, GH1, CYP11A1, SHBG, NPY
23	nifedipine32 9 9	9.7	LEP, REN, CGB5, GNRH1, GH1, CYP11A1
24	progestin32	7.7	CGA, GNRH1, SHBG, PRL, CYP17A1, CYP11A1
25	forskolin32 42 9 9	10.7	FGFR1, CGA, GNRHR, GH1, REN, TRH
26	triiodothyronine32	7.6	TRH, CGA, GH1, IGF1, SHBG, PRL
27	testosterone32 9 18 9	10.5	KISS1, CGA, FSHB, FGFR1, GNRH1, GNRHR
28	leuprolide acetate32	7.5	PRL, SHBG, CYP19A1, GH1, GNRHR, GNRH1
29	hydrocortisone32 9 9	9.5	REN, IGF1, GH1, TRH, CYP19A1, PRL
30	clonidine32 9 9	9.4	PRL, CGA, IGF1, GH1, LEP, REN
31	corticosterone32 18	8.3	GH1, CGB5, LEP, PRL, REN, CYP17A1
32	metformin32 34 9 9	10.2	LSL, SHBG, CYP19A1, CYP17A1, CYP11A1, GH1
33	estradiol32 9 18 9	10.1	CYP17A1, CYP11A1, TRH, GNRHR, FSHR, FSHB
34	epinephrine32 9 18 9	10.1	CGB5, GH1, PRL, LSL, NPY, GNRH1
35	ribonucleic acid32	7.1	GNRHR, GNRH1, IGF1, FGFR1, FSHR, FSHB
36	norepinephrine32 9 18 9	9.9	PRL, NPY, LSL, GH1, GNRH1, CGB5
37	thyroxine32 18	7.8	NPY, PRL, LSL, SHBG, TRH, GNRH1
38	estrone32 9 18 9	9.7	CYP17A1, GH1, IGF1, SHBG, CGB5, CYP19A1
39	dhea32	6.7	PRL, LSL, SHBG, CYP19A1, CYP17A1, CYP11A1
40	progesterone32 42 9 18 9	10.6	PRL, CYP19A1, CYP17A1, CYP11A1, TRH, GH1
41	dehydroepiandrosterone sulfate32	6.3	CGB5, IGF1, CGA, LEP, GNRH1, PRL
42	tamoxifen32 34 9 9	9.3	PRL, LSL, SHBG, CYP19A1, IGF1, GNRHR
43	dihydrotestosterone32 9 18 9	9.3	CGB5, CGA, IGF1, GNRH1, PRL, SHBG
44	gnrh32	5.8	KISS1R, LEP, CGB5, KAL1, FSHB, CYP17A1
45	acth32	5.7	LSL, SHBG, CYP17A1, CYP11A1, TRH, GH1
46	androstenedione32 18	6.5	PRL, LSL, SHBG, CYP19A1, CYP17A1, CYP11A1
47	dexamethasone32 42 34 9 9	9.5	CYP11A1, CGB5, LEP, SCNN1A, REN, PRL
48	arginine32	5.2	POU1F1, PRL, CGB5, CGA, NPY, REN
49	estrogen32	4.6	LEP, PRL, POU1F1, NPY, LSL, SHBG
50	steroid32	4.2	FSHB, REN, KISS1, LEP, CGA, CGB5

Cellular components related to delayed puberty according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	sodium channel complex	GO:034706	9.9	SCNN1A, SCNN1B
2	extracellular space	GO:005615	7.4	LEP, IHH, IGF1, GNRH1, GH1, NPY
3	extracellular region	GO:005576	6.3	KISS1, NPY, PRL, SHBG, TRH, GH1

Biological processes related to delayed puberty according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	follicle-stimulating hormone secretion	GO:046884	10.4	TBX3, CGA
2	luteinizing hormone secretion	GO:032275	10.4	CGA, TBX3
3	nose development	GO:043584	10.2	CHD7, HESX1
4	phenol-containing compound metabolic process	GO:018958	10.2	CYP17A1, CYP11A1
5	sensory perception of taste	GO:050909	10.1	SCNN1A, SCNN1B, NPY
6	progesterone biosynthetic process	GO:006701	10.0	FSHB, CYP11A1
7	response to insecticide	GO:017085	10.0	CYP17A1, CYP11A1
8	cell maturation	GO:048469	9.7	IHH, REN, FGFR1
9	phthalate metabolic process	GO:018963	9.7	CYP19A1, CYP17A1, CYP11A1
10	biphenyl metabolic process	GO:018879	9.7	CYP11A1, CYP17A1, CYP19A1
11	dibenzo-p-dioxin metabolic process	GO:018894	9.7	CYP17A1, CYP19A1, CYP11A1
12	response to herbicide	GO:009635	9.6	CYP19A1, CYP17A1
13	hippocampus development	GO:021766	9.5	CYP19A1, CYP17A1, CYP11A1
14	central nervous system neuron development	GO:021954	9.4	LEP, NPY, FGFR1
15	bone mineralization involved in bone maturation	GO:035630	9.4	IGF1, LEP
16	skeletal system development	GO:001501	9.2	FGFR1, IGF1, TBX3, CHD7
17	female pregnancy	GO:007565	9.1	PRL, FSHB, GNRH1, LEP
18	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	8.9	IGF1, FGFR1, GH1
19	positive regulation of cell proliferation	GO:008284	8.6	LEP, FGFR1, IGF1, TBX3, CGA, FSHB

Molecular functions related to delayed puberty according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	prolactin receptor binding	GO:005148	9.5	GH1, PRL
2	hormone activity	GO:005179	7.4	LEP, CGA, FSHB, IGF1, GNRH1, GH1