MCID: DLY005
MIFTS: 20

Delayed Sleep Phase Syndrome malady

Summaries for Delayed Sleep Phase Syndrome

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Delayed sleep-phase disorder (DSPD), also known as delayed sleep-phase syndrome (DSPS) or delayed... more...

MalaCards: Delayed Sleep Phase Syndrome is related to sleep disorder and advanced sleep phase syndrome. An important gene associated with Delayed Sleep Phase Syndrome is AANAT (aralkylamine N-acetyltransferase), and among its related pathways are Metabolic States and Circadian Oscillators and Circadian rhythm pathway. The compounds Coenzyme A and arylalkylamine have been mentioned in the context of this disorder.

Description from OMIM:46 614163

Aliases & Classifications for Delayed Sleep Phase Syndrome

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Sources:
46OMIM, 44Novoseek, 60UMLS
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Aliases & Descriptions:

delayed sleep phase syndrome 46 44 60


Related Diseases for Delayed Sleep Phase Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Delayed Sleep Phase Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1sleep disorder30.6CLOCK, PER2
2advanced sleep phase syndrome30.2PER3, PER2
3obsessive-compulsive disorder10.2
4good syndrome10.2
5seasonal affective disorder10.2
6adult syndrome10.2
7n syndrome10.2
8bipolar disorder10.0CLOCK
9hepatocellular carcinoma10.0HLA-DRB1
10schizophrenia10.0HLA-DRB1, CLOCK
11breast cancer10.0PER3, PER2

Graphical network of diseases related to Delayed Sleep Phase Syndrome:



Diseases related to delayed sleep phase syndrome

Clinical Features for Delayed Sleep Phase Syndrome

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46OMIM
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Clinical features from OMIM:

614163

Drugs & Therapeutics for Delayed Sleep Phase Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Delayed Sleep Phase Syndrome

Drug clinical trials:

Search ClinicalTrials for Delayed Sleep Phase Syndrome

Search NIH Clinical Center for Delayed Sleep Phase Syndrome

Search CenterWatch for Delayed Sleep Phase Syndrome

Genetic Tests for Delayed Sleep Phase Syndrome

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Anatomical Context for Delayed Sleep Phase Syndrome

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Animal Models for Delayed Sleep Phase Syndrome or affiliated genes

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Publications for Delayed Sleep Phase Syndrome

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Genetic Variations for Delayed Sleep Phase Syndrome

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Delayed Sleep Phase Syndrome:

62
id Symbol AA change Variation ID SNP ID
1AANATp.Ala129ThrVAR_055086rs28936679

Expression for genes affiliated with Delayed Sleep Phase Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Delayed Sleep Phase Syndrome

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Pathways for genes affiliated with Delayed Sleep Phase Syndrome

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 53Reactome
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Compounds for genes affiliated with Delayed Sleep Phase Syndrome

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Sources:
11DrugBank, 24HMDB, 44Novoseek, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Delayed Sleep Phase Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Coenzyme A11 2410.5AANAT, CLOCK
2arylalkylamine449.2AANAT, CLOCK
3melatonin44 59 28 11 2412.0PER1, PER2, AANAT, CLOCK

GO Terms for genes affiliated with Delayed Sleep Phase Syndrome

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16Gene Ontology
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Biological processes related to Delayed Sleep Phase Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1circadian regulation of gene expressionGO:0329228.8CLOCK, PER1
2negative regulation of transcription from RNA polymerase II promoterGO:0001228.6PER1, PER2, PER3
3circadian rhythmGO:0076237.5PER1, PER2, PER3, AANAT, CLOCK

Molecular functions related to Delayed Sleep Phase Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:0009789.1PER1, CLOCK
2protein binding transcription factor activityGO:0009888.9PER2, PER1
3E-box bindingGO:0708888.8PER1, CLOCK
4signal transducer activityGO:0048718.1PER1, PER2, PER3, CLOCK

Products for genes affiliated with Delayed Sleep Phase Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Delayed Sleep Phase Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet