DSPS
MCID: DLY005
MIFTS: 37

Delayed Sleep Phase Syndrome (DSPS) malady

Categories: Genetic diseases

Aliases & Classifications for Delayed Sleep Phase Syndrome

Aliases & Descriptions for Delayed Sleep Phase Syndrome:

Name: Delayed Sleep Phase Syndrome 54 66 52 69
Delayed Sleep Phase Syndrome, Susceptibility to 13
Dsps 66

Classifications:



External Ids:

OMIM 54 614163
MeSH 42 D020178

Summaries for Delayed Sleep Phase Syndrome

OMIM : 54 Delayed sleep phase syndrome is a circadian rhythm sleep disorder characterized by sleep-onset insomnia and difficulty... (614163) more...

MalaCards based summary : Delayed Sleep Phase Syndrome, also known as delayed sleep phase syndrome, susceptibility to, is related to dsp-related ectodermal dysplasia/skin fragility syndrome and arrhythmogenic right ventricular dysplasia 1. An important gene associated with Delayed Sleep Phase Syndrome is AANAT (Aralkylamine N-Acetyltransferase), and among its related pathways/superpathways are Influenza A and Circadian entrainment. The drugs Armodafinil and Modafinil have been mentioned in the context of this disorder. Affiliated tissues include testes and brain.

UniProtKB/Swiss-Prot : 66 Delayed sleep phase syndrome: A circadian rhythm sleep disorder characterized by sleep-onset insomnia and difficulty in awakening at the desired time. Patients with DSPS have chronic difficulty in adjusting their sleep-onset and wake-up times to occupational, school, and social activities.

Wikipedia : 71 Delayed sleep phase disorder (DSPD), also known as delayed sleep phase syndrome or delayed sleep phase... more...

Related Diseases for Delayed Sleep Phase Syndrome

Graphical network of the top 20 diseases related to Delayed Sleep Phase Syndrome:



Diseases related to Delayed Sleep Phase Syndrome

Symptoms & Phenotypes for Delayed Sleep Phase Syndrome

Clinical features from OMIM:

614163

Drugs & Therapeutics for Delayed Sleep Phase Syndrome

Drugs for Delayed Sleep Phase Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Armodafinil Approved, Investigational Phase 4 112111-43-0
2
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
3
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 73-31-4 896
4 Antioxidants Phase 4,Phase 1
5 Central Nervous System Depressants Phase 4,Phase 2,Phase 1
6 Protective Agents Phase 4,Phase 1
7 Central Nervous System Stimulants Phase 4
8 Cytochrome P-450 CYP3A Inducers Phase 4
9 Wakefulness-Promoting Agents Phase 4
10 Anesthetics Phase 4,Phase 2
11 Brexpiprazole Approved Phase 3 913611-97-9 11978813
12
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
13 Antipsychotic Agents Phase 3
14 Dopamine Agents Phase 3
15 Dopamine agonists Phase 3
16 Neurotransmitter Agents Phase 3
17
Serotonin Phase 3 50-67-9 5202
18 Serotonin Agents Phase 3
19
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
20
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
21
Oxymetazoline Approved Phase 2 1491-59-4 4636
22
Phenylephrine Approved Phase 2 59-42-7 6041
23 Anesthetics, Local Phase 2
24 Epinephryl borate Phase 2
25 Hemostatics Phase 2
26 Pharmaceutical Solutions Phase 2
27 Racepinephrine Phase 2
28 Liver Extracts Phase 2
29 Anti-Arrhythmia Agents Phase 2
30 Diuretics, Potassium Sparing Phase 2
31 Peripheral Nervous System Agents Phase 2
32 Sodium Channel Blockers Phase 2
33
Cocaine Approved, Illicit 50-36-2 5760 446220

Interventional clinical trials:

(show all 26)
id Name Status NCT ID Phase
1 Randomized Controlled Trial on the Treatment Effects of Melatonin and Light Therapy on Delayed Sleep Phase Syndrome Completed NCT00834886 Phase 4
2 Study to Evaluate Armodafinil Treatment in Improving Prefrontal Cortical Activation and Working Memory Performance Completed NCT00711516 Phase 4
3 Oxygen Versus Medical Air for Treatment of CSA in Prader Will Syndrome Recruiting NCT03031626 Phase 4
4 Evaluation of Modafinil vs Placebo for Treatment of Anesthesia Delayed Emergence in Obstructive Sleep Apnea Recruiting NCT02494102 Phase 4
5 Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities Before Handling the Disorder? Not yet recruiting NCT02962037 Phase 4
6 Cognitive Behavioral Insomnia Therapy for Individuals With Fibromyalgia Completed NCT00321451 Phase 2, Phase 3
7 Apnea Positive Pressure Long-Term Efficacy Study Completed NCT00051363 Phase 3
8 Mild Cognitive Impairment and Obstructive Sleep Apnea Completed NCT01482351 Phase 3
9 Monotherapy Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Early-Episode Schizophrenia Completed NCT02013622 Phase 3
10 Intranasal Mometasone in Children With Obstructive Sleep Apnea Due to Adenotonsillar Hypertrophy Withdrawn NCT01671852 Phase 3
11 Efficacy of Ramelteon on Speeding Up Sleep in Subjects With Delayed Sleep Phase Syndrome Completed NCT00593736 Phase 2
12 Safety, Tolerability, Ascending Dose and Dose Frequency Study of rhHNS Via an IDDD in MPS IIIA Patients Completed NCT01155778 Phase 1, Phase 2
13 Randomized Clinical Trial of Nasal Turbinate Reduction to Improve Continuous Positive Airway Pressure (CPAP) Outcomes for Sleep Apnea Completed NCT00503802 Phase 2
14 The Sleep, Liver Evaluation and Effective Pressure Study Completed NCT01482065 Phase 2
15 A Trial of Lidocaine Patch for Lower Limb Amputation Pain Recruiting NCT02696720 Phase 2
16 Extension of Study HGT-SAN-055 Evaluating Administration of rhHNS in Patients With Sanfilippo Syndrome Type A (MPS IIIA) Active, not recruiting NCT01299727 Phase 1, Phase 2
17 Synchronization and Desynchronization Between Circadian Rhythms in Patients With Delayed Sleep Phase Syndrome (DSPS) Unknown status NCT00282061 Phase 1
18 Treatment Strategies for Children With Smith-Magenis Syndrome Recruiting NCT00506259 Phase 1
19 Comparison of Dialysis Therapies on Cognitive Function Unknown status NCT00597103
20 Recognition and Early Intervention on Prodrome in Bipolar Disorders Unknown status NCT01863628
21 Does Cognitive Behaviour Therapy (CBT) Improve the Effect of Light Therapy Completed NCT01419938
22 Melatonin Treatment for Induced Transient Insomnia Completed NCT00950885
23 Effects of Light Treatment During Sleep on Young Men Completed NCT00796939
24 Sleep Length and Circadian Regulation in Humans Completed NCT00843843
25 Circadian Rhythms and Sleep in Familial DSPS and ASPS Recruiting NCT00246454
26 CPAP to Treat Cognitive Dysfunction in MS Recruiting NCT02544373

Search NIH Clinical Center for Delayed Sleep Phase Syndrome

Genetic Tests for Delayed Sleep Phase Syndrome

Anatomical Context for Delayed Sleep Phase Syndrome

MalaCards organs/tissues related to Delayed Sleep Phase Syndrome:

39
Testes, Brain

Publications for Delayed Sleep Phase Syndrome

Articles related to Delayed Sleep Phase Syndrome:

(show top 50) (show all 79)
id Title Authors Year
1
Aripiprazole is effective for treatment of delayed sleep phase syndrome. ( 24992089 )
2014
2
Delayed sleep phase syndrome in adolescents: prevalence and correlates in a large population based study. ( 24330358 )
2013
3
Delayed sleep phase syndrome: a forerunner of psychiatric distress. ( 24304991 )
2013
4
Delayed sleep phase syndrome is related to seasonal affective disorder. ( 21601293 )
2011
5
Relation between morningness-eveningness score and depressive symptoms among patients with delayed sleep phase syndrome. ( 21669551 )
2011
6
Delayed sleep phase syndrome and depression. ( 21704558 )
2011
7
Total sleep deprivation study in delayed sleep-phase syndrome. ( 23250347 )
2011
8
Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome. ( 20044310 )
2010
9
Sleep and circadian abnormalities in patients with cirrhosis: features of delayed sleep phase syndrome? ( 19756996 )
2009
10
Sleep timing and circadian phase in delayed sleep phase syndrome. ( 19625733 )
2009
11
Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome. ( 18725185 )
2009
12
The prevalence of probable delayed-sleep-phase syndrome in students from junior high school to university in Tottori, Japan. ( 18719343 )
2008
13
A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. ( 18078449 )
2008
14
A prospective study of delayed sleep phase syndrome in patients with severe resistant obsessive-compulsive disorder. ( 18235868 )
2007
15
Constant light housing during nursing causes human DSPS (delayed sleep phase syndrome) behaviour in Clock-mutant mice. ( 17445238 )
2007
16
Delayed sleep phase syndrome, ADHD, and bright light therapy. ( 17335340 )
2007
17
Attention bias for sleep-related stimuli in primary insomnia and delayed sleep phase syndrome using the dot-probe task. ( 17162988 )
2006
18
Circadian phase in delayed sleep phase syndrome: predictors and temporal stability across multiple assessments. ( 16944677 )
2006
19
Who is pre-occupied with sleep? A comparison of attention bias in people with psychophysiological insomnia, delayed sleep phase syndrome and good sleepers using the induced change blindness paradigm. ( 16704577 )
2006
20
Melatonin treatment in adolescents with delayed sleep phase syndrome. ( 17041168 )
2006
21
Timed melatonin treatment for delayed sleep phase syndrome: the importance of knowing circadian phase. ( 16295202 )
2005
22
Phase-dependent treatment of delayed sleep phase syndrome with melatonin. ( 16295212 )
2005
23
Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it? ( 15700718 )
2005
24
Delayed sleep phase syndrome: pathophysiology and treatment options. ( 15532214 )
2004
25
The psychological aspects of patients with delayed sleep phase syndrome (DSPS). ( 14592284 )
2003
26
A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. ( 12841365 )
2003
27
Sleep and circadian rhythm disturbances in patients with delayed sleep phase syndrome. ( 14572116 )
2003
28
Significant association of the arylalkylamine N-acetyltransferase (AA-NAT) gene with delayed sleep phase syndrome. ( 12736803 )
2003
29
Physical symptoms under forced-phase advance treatment in a patient with delayed sleep phase syndrome: a case report. ( 12047565 )
2002
30
Bright-light mask treatment of delayed sleep phase syndrome. ( 11837952 )
2002
31
Hypersensitivity of melatonin suppression in response to light in patients with delayed sleep phase syndrome. ( 11379666 )
2001
32
A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome. ( 11211063 )
2001
33
A pedigree of one family with delayed sleep phase syndrome. ( 11763990 )
2001
34
Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. ( 11306557 )
2001
35
Altered phase relation between sleep timing and core body temperature rhythm in delayed sleep phase syndrome and non-24-hour sleep-wake syndrome in humans. ( 11058797 )
2000
36
Posttraumatic delayed sleep phase syndrome. ( 10636163 )
2000
37
Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome. ( 10750629 )
2000
38
Poor compensatory function for sleep loss as a pathogenic factor in patients with delayed sleep phase syndrome. ( 10875562 )
2000
39
Is the delayed sleep phase syndrome a physical or psychological disease? A case report of disappearance following a change of latitude. ( 11043803 )
2000
40
Effects of phototherapy on the phase relationship between sleep and body temperature rhythm in a delayed sleep phase syndrome case. ( 11186119 )
2000
41
Predisposing factors in delayed sleep phase syndrome. ( 11186112 )
2000
42
Post-traumatic delayed sleep phase syndrome. ( 10994031 )
2000
43
Effects of phototherapy in patients with delayed sleep phase syndrome. ( 10459696 )
1999
44
Melatonin rhythms in delayed sleep phase syndrome. ( 10036995 )
1999
45
Poor recovery sleep after sleep deprivation in delayed sleep phase syndrome. ( 10459687 )
1999
46
Light mask 500 lux treatment for delayed sleep phase syndrome. ( 10368853 )
1999
47
Possible association of human leucocyte antigen DR1 with delayed sleep phase syndrome. ( 10498237 )
1999
48
Polysomnography and body temperature changes by phototherapy in a delayed sleep phase syndrome case. ( 9628182 )
1998
49
Frequency of delayed sleep phase syndrome among hospitalized adolescent psychiatric patients. ( 9720851 )
1998
50
Correlation between concentrations of melatonin in saliva and serum in patients with delayed sleep phase syndrome. ( 9558132 )
1998

Variations for Delayed Sleep Phase Syndrome

Expression for Delayed Sleep Phase Syndrome

Search GEO for disease gene expression data for Delayed Sleep Phase Syndrome.

Pathways for Delayed Sleep Phase Syndrome

GO Terms for Delayed Sleep Phase Syndrome

Biological processes related to Delayed Sleep Phase Syndrome according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.7 CLOCK PER1 PER2
2 regulation of insulin secretion GO:0050796 9.51 CLOCK PER2
3 regulation of circadian rhythm GO:0042752 9.49 PER1 PER2
4 response to cAMP GO:0051591 9.48 AANAT PER1
5 response to light stimulus GO:0009416 9.46 AANAT PER1
6 circadian regulation of gene expression GO:0032922 9.46 CLOCK PER1 PER2 PER3
7 histone H3 deacetylation GO:0070932 9.43 PER1 PER2
8 negative regulation of glucocorticoid receptor signaling pathway GO:2000323 9.4 CLOCK PER1
9 regulation of hair cycle GO:0042634 9.37 CLOCK PER1
10 rhythmic process GO:0048511 9.35 AANAT CLOCK PER1 PER2 PER3
11 circadian regulation of translation GO:0097167 9.32 PER1 PER2
12 photoperiodism GO:0009648 9.26 AANAT CLOCK
13 circadian rhythm GO:0007623 9.02 AANAT CLOCK PER1 PER2 PER3

Molecular functions related to Delayed Sleep Phase Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 kinase binding GO:0019900 9.32 PER1 PER3
2 chromatin DNA binding GO:0031490 9.26 CLOCK PER1
3 transcription regulatory region sequence-specific DNA binding GO:0000976 9.16 PER1 PER2
4 E-box binding GO:0070888 8.96 CLOCK PER1
5 transcription factor activity, transcription factor binding GO:0000989 8.62 PER1 PER2

Sources for Delayed Sleep Phase Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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