MCID: DLY005
MIFTS: 31

Delayed Sleep Phase Syndrome malady

Genetic diseases (common) category
Download this MalaCard

Summaries for Delayed Sleep Phase Syndrome

About this section


Fully expand this MalaCard
Wikipedia:65 Delayed sleep-phase disorder (DSPD), also known as delayed sleep-phase syndrome (DSPS) or delayed... more...

MalaCards based summary: Delayed Sleep Phase Syndrome is related to blindness and obsessive-compulsive disorder. An important gene associated with Delayed Sleep Phase Syndrome is AANAT (aralkylamine N-acetyltransferase), and among its related pathways are Selected targets of CREB1 and Circadian rhythm pathway. The compounds acetyl-coa and arylalkylamine have been mentioned in the context of this disorder. Affiliated tissues include testes, and related mouse phenotypes are behavior/neurological and nervous system.

Description from OMIM:46 614163

Aliases & Classifications for Delayed Sleep Phase Syndrome

About this section
Sources:
46OMIM, 44Novoseek, 62UMLS
See all sources

Delayed Sleep Phase Syndrome, Aliases & Descriptions:

Name: Delayed Sleep Phase Syndrome 46 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Delayed Sleep Phase Syndrome

About this section

Diseases related to Delayed Sleep Phase Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1blindness10.5
2obsessive-compulsive disorder10.2
3seasonal affective disorder10.2
4headache10.2
5advanced sleep phase syndrome10.0PER3, PER2
6narcolepsy10.0HLA-DRB1, CLOCK
7sleep disorder9.8CLOCK, PER2

Graphical network of diseases related to Delayed Sleep Phase Syndrome:



Diseases related to delayed sleep phase syndrome

Symptoms for Delayed Sleep Phase Syndrome

About this section


Clinical features from OMIM:

614163

Drugs & Therapeutics for Delayed Sleep Phase Syndrome

About this section

Drug clinical trials:

Search ClinicalTrials for Delayed Sleep Phase Syndrome

Search NIH Clinical Center for Delayed Sleep Phase Syndrome

Genetic Tests for Delayed Sleep Phase Syndrome

About this section

Anatomical Context for Delayed Sleep Phase Syndrome

About this section

MalaCards organs/tissues related to Delayed Sleep Phase Syndrome:

32
Testes

Animal Models for Delayed Sleep Phase Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Delayed Sleep Phase Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.1CLOCK, PER3, PER1, PER2
2MP:00036317.3AANAT, CLOCK, PER3, PER1, PER2

Publications for Delayed Sleep Phase Syndrome

About this section

Articles related to Delayed Sleep Phase Syndrome:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Delayed sleep phase syndrome: a forerunner of psychiatric distress. (24304991)
2013
2
Relation between morningness-eveningness score and depressive symptoms among patients with delayed sleep phase syndrome. (21669551)
2011
3
Delayed sleep phase syndrome is related to seasonal affective disorder. (21601293)
2011
4
Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome. (20044310)
2010
5
Clinical efficacy of dim light melatonin onset testing in diagnosing delayed sleep phase syndrome. (18725185)
2009
6
Sleep timing and circadian phase in delayed sleep phase syndrome. (19625733)
2009
7
A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. (18078449)
2008
8
Delayed sleep phase syndrome, ADHD, and bright light therapy. (17335340)
2007
9
Constant light housing during nursing causes human DSPS (delayed sleep phase syndrome) behaviour in Clock-mutant mice. (17445238)
2007
10
Who is pre-occupied with sleep? A comparison of attention bias in people with psychophysiological insomnia, delayed sleep phase syndrome and good sleepers using the induced change blindness paradigm. (16704577)
2006
11
Attention bias for sleep-related stimuli in primary insomnia and delayed sleep phase syndrome using the dot-probe task. (17162988)
2006
12
Phase-dependent treatment of delayed sleep phase syndrome with melatonin. (16295212)
2005
13
Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it? (15700718)
2005
14
Sleep and circadian rhythm disturbances in patients with delayed sleep phase syndrome. (14572116)
2003
15
Significant association of the arylalkylamine N-acetyltransferase (AA-NAT) gene with delayed sleep phase syndrome. (12736803)
2003
16
A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. (12841365)
2003
17
The psychological aspects of patients with delayed sleep phase syndrome (DSPS). (14592284)
2003
18
Hypersensitivity of melatonin suppression in response to light in patients with delayed sleep phase syndrome. (11379666)
2001
19
A pedigree of one family with delayed sleep phase syndrome. (11763990)
2001
20
Predisposing factors in delayed sleep phase syndrome. (11186112)
2000
21
Poor compensatory function for sleep loss as a pathogenic factor in patients with delayed sleep phase syndrome. (10875562)
2000
22
Posttraumatic delayed sleep phase syndrome. (10636163)
2000
23
Post-traumatic delayed sleep phase syndrome. (10994031)
2000
24
Is the delayed sleep phase syndrome a physical or psychological disease? A case report of disappearance following a change of latitude. (11043803)
2000
25
Effects of phototherapy on the phase relationship between sleep and body temperature rhythm in a delayed sleep phase syndrome case. (11186119)
2000
26
Possible association of human leucocyte antigen DR1 with delayed sleep phase syndrome. (10498237)
1999
27
Poor recovery sleep after sleep deprivation in delayed sleep phase syndrome. (10459687)
1999
28
Effects of phototherapy in patients with delayed sleep phase syndrome. (10459696)
1999
29
Light mask 500 lux treatment for delayed sleep phase syndrome. (10368853)
1999
30
Correlation between concentrations of melatonin in saliva and serum in patients with delayed sleep phase syndrome. (9558132)
1998
31
Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. (9595871)
1998
32
Frequency of delayed sleep phase syndrome among hospitalized adolescent psychiatric patients. (9720851)
1998
33
Wrist activity rhythm and sleep diary of delayed sleep phase syndrome. (9628183)
1998
34
Vitamin B12 treatment for delayed sleep phase syndrome: a multi-center double-blind study. (9413873)
1997
35
Effects of light and chronotherapy on human circadian rhythms in delayed sleep phase syndrome: cytokines, cortisol, growth hormone, and the sleep-wake cycle. (8894073)
1996
36
Abnormal circadian rhythms of plasma melatonin and body temperature in the delayed sleep phase syndrome. (7897427)
1995
37
Delayed sleep phase syndrome: a review of its clinical aspects. (7694911)
1995
38
Melatonin and delayed sleep phase syndrome: ambulatory polygraphic evaluation. (7703401)
1994
39
Long-term course of adult patients with delayed sleep phase syndrome. (8301870)
1993
40
Successful combined treatment with vitamin B12 and bright artificial light of one case with delayed sleep phase syndrome. (8271628)
1993
41
Successful use of S20098 and melatonin in an animal model of delayed sleep-phase syndrome (DSPS). (8255922)
1993
42
A polysomnographic study on patients with delayed sleep phase syndrome (DSPS). (1635316)
1992
43
When the body clock goes wrong: delayed sleep phase syndrome. (1357304)
1992
44
A case with delayed sleep phase syndrome showing a significant seasonal variation in sleep-wake cycle. (1753481)
1991
45
Two cases of delayed sleep phase syndrome (DSPS). (1753473)
1991
46
Phase-shifting effects of bright morning light as treatment for delayed sleep phase syndrome. (2267478)
1990
47
A treatment trial of delayed sleep phase syndrome with triazolam. (2739169)
1989
48
Delayed sleep phase syndrome in adolescents. (3335467)
1988
49
Body temperature monitoring in subjects with delayed sleep phase syndrome. (3255890)
1988
50
Delayed sleep phase syndrome. A chronobiological disorder with sleep-onset insomnia. (7247637)
1981

Variations for Delayed Sleep Phase Syndrome

About this section

UniProtKB/Swiss-Prot genetic disease variations for Delayed Sleep Phase Syndrome:

64
id Symbol AA change Variation ID SNP ID
1AANATp.Ala129ThrVAR_055086rs28936679

Clinvar genetic disease variations for Delayed Sleep Phase Syndrome:

6
id Gene Name Type Significance SNP ID Assembly Location
1AANATNM_001166579.1(AANAT): c.520G> A (p.Ala174Thr)single nucleotide variantrisk factorrs28936679GRCh37Chr 17, 74465813: 74465813

Expression for genes affiliated with Delayed Sleep Phase Syndrome

About this section
Expression patterns in normal tissues for genes affiliated with Delayed Sleep Phase Syndrome

Search GEO for disease gene expression data for Delayed Sleep Phase Syndrome.

Pathways for genes affiliated with Delayed Sleep Phase Syndrome

About this section

Compounds for genes affiliated with Delayed Sleep Phase Syndrome

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 61Tocris Bioscience
See all sources

Compounds related to Delayed Sleep Phase Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1acetyl-coa44 2410.4AANAT, CLOCK
2arylalkylamine449.3CLOCK, AANAT
3Coenzyme A24 1110.1AANAT, CLOCK
4melatonin44 28 61 24 1112.1AANAT, CLOCK, PER1, PER2

GO Terms for genes affiliated with Delayed Sleep Phase Syndrome

About this section

Biological processes related to Delayed Sleep Phase Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of hair cycleGO:0426348.7CLOCK, PER1
2negative regulation of transcription from RNA polymerase II promoterGO:0001228.7PER2, PER1, PER3
3circadian regulation of gene expressionGO:0329228.5PER1, PER3, CLOCK
4circadian rhythmGO:0076238.1PER2, AANAT, CLOCK, PER1

Molecular functions related to Delayed Sleep Phase Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor binding transcription factor activityGO:0009899.0PER2, PER1
2RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:0009789.0CLOCK, PER1
3E-box bindingGO:0708888.7CLOCK, PER1
4signal transducer activityGO:0048718.1CLOCK, PER3, PER1, PER2

Products for genes affiliated with Delayed Sleep Phase Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Delayed Sleep Phase Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet