MCID: DLS001
MIFTS: 45

Delusional Disorder malady

Mental diseases category
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Summaries for Delusional Disorder

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.

MalaCards: Delusional Disorder is related to schizophrenia and schizoaffective disorder. An important gene associated with Delusional Disorder is DRD3 (dopamine receptor D3), and among its related pathways are GPCRs, Other and Hypothetical Network for Drug Addiction. The compounds trans flupenthixol and pd 128907 have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:65 Delusional disorder is an uncommon psychiatric condition in which patients present with delusions, but... more...

Aliases & Classifications for Delusional Disorder

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8Disease Ontology, 10DISEASES, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

delusional disorder 8 10 62


External Ids:

Disease Ontology8 DOID:778
MeSH35 D012563
SNOMED-CT58 48500005, 192330005
ICD9CM27 297.1
ICD1025 F22.0

Related Diseases for Delusional Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Delusional Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia30.9TH, DRD4, DRD3, DRD2
2schizoaffective disorder30.3DRD4, DRD3, DRD2
3alcohol dependence30.1DRD2, DRD4
4alcohol abuse30.1DRD2, DRD3
5bipolar disorder30.1TH, DRD2
6personality disorder30.0DRD2, DRD3, DRD4
7psychotic disorder30.0DRD2, DRD3, DRD4, TH
8mood disorder30.0DRD2, DRD3, DRD4, TH
9parkinson's disease29.9TH, DRD4, DRD3, DRD2
10paranoid schizophrenia10.3
11body dysmorphic disorder10.3
12capgras syndrome10.2
13anorexia nervosa10.2
14dementia10.2
15myoclonus-dystonia10.1DRD2
16oppositional defiant disorder10.1DRD4
17opiate dependence10.0DRD2, DRD3
18drug dependence10.0DRD2, DRD3
19major depressive disorder10.0
20pain disorder10.0
21phenylketonuria10.0
22schizophreniform disorder10.0
23dyslexia10.0
24social phobia10.0
25cerebritis10.0
26von hippel-lindau disease10.0
27acute orbital inflammation10.0
28cerebrovascular disease10.0
29charcot-marie-tooth disease10.0
30neuropathy10.0
31peripheral neuropathy10.0
32sleep apnea10.0
33tooth disease10.0
34trimethylaminuria10.0
35argyrophilic grain disease10.0
36cocaine dependence10.0DRD2, DRD3
37heroin dependence10.0DRD4, DRD2
38drug addiction10.0DRD3, DRD2
39conduct disorder10.0DRD2, DRD4
40gilles de la tourette syndrome10.0DRD4, DRD2
41nicotine dependence10.0DRD2, DRD4
42progressive supranuclear palsy10.0TH, DRD2
43attention deficit hyperactivity disorder10.0DRD4, DRD2
44multiple system atrophy10.0DRD2, TH
45pathological gambling10.0DRD4, DRD3, DRD2
46substance dependence10.0DRD4, DRD3, DRD2
47obsessive-compulsive disorder10.0DRD4, DRD3, DRD2
48substance abuse10.0DRD2, DRD3, DRD4
49pheochromocytoma10.0DRD2, TH
50migraine10.0DRD2, DRD3, DRD4

Graphical network of the top 20 diseases related to Delusional Disorder:



Diseases related to delusional disorder

Symptoms for Delusional Disorder

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Drugs & Therapeutics for Delusional Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Delusional Disorder

Search NIH Clinical Center for Delusional Disorder

Genetic Tests for Delusional Disorder

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Anatomical Context for Delusional Disorder

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33MalaCards
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MalaCards organs/tissues related to Delusional Disorder:

33
Eye

Animal Models for Delusional Disorder or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Delusional Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.4DRD2, DRD3, DRD4, TH
2MP:00053868.1DRD2, DRD3, DRD4, TH

Publications for Delusional Disorder

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Sources:
52PubMed
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Articles related to Delusional Disorder:

(show top 50)    (show all 142)
idTitleAuthorsYear
1
Delusional disorder and oncology: review of the literature and case report. (24066407)
2013
2
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. (24272318)
2013
3
Low-dose quetiapine for the treatment of delusional disorder in a patient with Von Hippel-Lindau disease. (24026746)
2013
4
Comparative efficacy and acceptability of existing pharmacotherapies for delusional disorder: a retrospective case series and review of the literature. (23771191)
2013
5
Delusional disorders--are they simply paranoid schizophrenia? (21078814)
2012
6
Imprisonment, alcohol dependence and risk of delusional disorder: a cross-sectional study. (22608012)
2012
7
Delusional disorder. (22396352)
2012
8
Neuropsychological research in delusional disorder: a comprehensive review. (22269940)
2012
9
Comorbidity of delusional disorder with bipolar disorder: report of four cases. (21652084)
2011
10
Gender differences in delusional disorder: Evidence from an outpatient sample. (20334930)
2010
11
Delusional disorder and alcohol abuse in a patient with Wilson's disease. (19061688)
2008
12
Delusional disorder-jealous type: how inclusive are the DSM-IV diagnostic criteria? (18257054)
2008
13
Serum cholesterol concentrations in suicidal and non-suicidal male patients suffering from persistent delusional disorder. (18405068)
2008
14
Successful treatment of delusional disorder with low-dose aripiprazole. (18588606)
2008
15
A descriptive case-register study of delusional disorder. (18082379)
2008
16
Involuntary medication treatment for competency restoration of 22 defendants with delusional disorder. (17389345)
2007
17
Monosymptomatic delusional disorder with delusion of poverty. (16633215)
2006
18
Genetic associations between delusional disorder and paranoid schizophrenia: A novel etiologic approach. (16786814)
2006
19
A hypothetical clinical vignette of delusional disorder: how potential legal issues could be addressed in the United Kingdom and the United States. (16773627)
2006
20
Folie a deux versus genetically driven delusional disorder: case reports and nosological considerations. (14999667)
2004
21
Making psychiatric sense of sand: a case of delusional disorder in Saudi Arabia. (15446724)
2004
22
Stalking behavior - an overview of the problem and a case report of male-to-male stalking during delusional disorder. (12457023)
2002
23
The relationship of olfactory delusional disorder to social phobia. (11838032)
2002
24
Magnetic resonance imaging findings in patients with delusional disorder due to diffuse cerebrovascular disease: a report of seven cases. (11285090)
2001
25
Occurrence and clinical correlates of psychiatric co-morbidity in delusional disorder. (11418272)
2001
26
Delusional disorder: retrospective analysis of 86 Chinese outpatients. (10687749)
1999
27
Effects of pimozide on the psychopathology of delusional disorder. (9608605)
1998
28
Expression and characterization of a dopamine D4R variant associated with delusional disorder. (9489994)
1998
29
Delusional disorder in a boy with phenylketonuria and amine metabolites in the cerebrospinal fluid after treatment with neuroleptics. (9502013)
1998
30
Organic delusional disorder in psychiatric in-patients: comparison with delusional disorder. (9065682)
1997
31
A case of somatic delusional disorder that responded to treatment with risperidone. (9413884)
1997
32
Induced delusional disorder in an adolescent : a case report. (21584103)
1997
33
Capgras syndrome and erotomanic type delusional disorder. (8811277)
1996
34
A clinical and neuropsychological comparison of delusional disorder and schizophrenia. (8854299)
1996
35
Episodic memory deficit in elderly adults with suspected delusional disorder. (8792905)
1996
36
Delusional disorder: the recognition and management of paranoia. (8626368)
1996
37
Drug treatment of schizophrenia and delusional disorder in late life. (9147173)
1996
38
Psychiatric liaison to family medicine. Patient with delusional disorder. (7894287)
1995
39
An overview of treatment in paranoia/delusional disorder. (8681259)
1995
40
Quantitative magnetic resonance imaging volumetry distinguishes delusional disorder from late-onset schizophrenia. (7804661)
1994
41
Clinical characteristics of late-onset schizophrenia and delusional disorder. (8303221)
1993
42
Delusional disorder and mood disorder: can they coexist? (8321893)
1993
43
Smooth pursuit eye movements and saccadic eye movements in patients with delusional disorder. (8352354)
1993
44
The duration criteria of delusional disorder in modern classification. (8321897)
1993
45
Delusional disorder: the predictive validity of the concept. (1683095)
1991
46
A delusional disorder that occurred in one of a pair of monozygotic twins. (2096235)
1990
47
Clomipramine treatment of delusional disorder-somatic type. (3360722)
1988
48
Long-term course and outcome in delusional disorder. (3232535)
1988
49
Toward an operationalization of reactive paranoid psychoses (reactive delusional disorder). (3423171)
1987
50
Delusional disorder (paranoia). (923223)
1977

Variations for Delusional Disorder

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Expression for genes affiliated with Delusional Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Delusional Disorder

Search GEO for disease gene expression data for Delusional Disorder.

Pathways for genes affiliated with Delusional Disorder

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 53QIAGEN, 51PharmGKB
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Pathways related to Delusional Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5DRD3, DRD4
29.4DRD2, DRD4
3
Show member pathways
9.3DRD2, TH
4
Show member pathways
9.0DRD4, DRD3, DRD2
5
Show member pathways
9.0DRD2, DRD3, DRD4
6
Show member pathways
9.0DRD4, DRD3, DRD2
79.0DRD4, DRD3, DRD2
8
Show member pathways
Nicotine Activity on Dopaminergic Neurons38
8.4DRD2, DRD3, DRD4, TH
9
Show member pathways
8.4DRD2, DRD3, DRD4, TH

Compounds for genes affiliated with Delusional Disorder

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Sources:
29IUPHAR, 45Novoseek, 51PharmGKB, 11DrugBank, 3BitterDB, 24HMDB, 61Tocris Bioscience
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Compounds related to Delusional Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1trans flupenthixol299.6DRD2, DRD3
2pd 12890729 4510.6DRD3, DRD2
3(+)-uh232299.5DRD3, DRD2
4[3h]nemonapride299.5DRD3, DRD2
5(-)-sulpiride299.4DRD4, DRD3, DRD2
6(+)-sulpiride299.4DRD4, DRD3, DRD2
7eticlopride45 2910.4DRD2, DRD3, DRD4
8nemonapride45 51 2911.4DRD2, DRD3, DRD4
9(+)-butaclamol45 2910.4DRD4, DRD3, DRD2
10sch 23390459.4DRD4, DRD3, DRD2
117-oh-dpat299.4DRD3, DRD2
12remoxipride45 1110.4DRD4, DRD3, DRD2
13piribedil29 4510.4DRD2, DRD3, DRD4
14benzamide3 4510.4DRD2, DRD3, DRD4
15rotigotine29 45 1111.4DRD4, DRD3, DRD2
16raclopride45 2910.4DRD4, DRD3, DRD2
17roxindole29 4510.4DRD2, DRD3, DRD4
18terguride45 2910.4DRD4, DRD3, DRD2
19spiperone45 2910.4DRD4, DRD3, DRD2
20piperazine45 1110.4DRD4, DRD3, DRD2
21sulpiride45 29 1111.3DRD4, DRD3, DRD2
22ropinirole45 1110.3DRD4, DRD3, DRD2
23lisuride45 29 1111.3DRD2, DRD3, DRD4
24paliperidone45 1110.3DRD4, DRD3, DRD2
25pergolide45 29 1111.3DRD4, DRD3, DRD2
26iloperidone51 45 29 1112.3DRD4, DRD3, DRD2
27asenapine29 1110.3DRD4, DRD3, DRD2
28cabergoline45 29 1111.3DRD2, DRD3, DRD4
29heroin45 51 1111.2DRD4, DRD3, DRD2
30aripiprazole29 45 51 24 1113.2DRD2, DRD3, DRD4
31domperidone45 29 1111.2DRD2, DRD3, TH
32ziprasidone29 51 45 1112.2DRD4, DRD3, DRD2
33(-)-n-porphynorapomorphine299.2DRD3, DRD2
34chlorpromazine29 45 51 1112.2DRD4, DRD3, DRD2
35methylphenidate45 51 1111.2TH, DRD4, DRD2
36bromocriptine45 29 1111.2DRD4, DRD3, DRD2
37maoa459.2TH, DRD4, DRD2
38risperidone45 51 29 61 24 1114.1DRD4, DRD3, DRD2
39pramipexole45 29 51 1111.8DRD2, DRD3, DRD4, TH
40quinpirole45 299.8TH, DRD4, DRD3, DRD2
41apomorphine29 45 1110.8TH, DRD4, DRD3, DRD2
42quetiapine45 51 29 24 1112.8TH, DRD4, DRD3, DRD2
43methamphetamine45 51 1110.8TH, DRD4, DRD3, DRD2
446-hydroxydopamine458.8TH, DRD4, DRD3, DRD2
45levodopa45 119.8TH, DRD4, DRD3, DRD2
46clozapine45 29 51 1111.8TH, DRD4, DRD3, DRD2
47haloperidol45 51 29 3 1112.7TH, DRD4, DRD3, DRD2
48cocaine45 119.7TH, DRD4, DRD3, DRD2
49nicotine45 29 51 1111.7DRD2, DRD3, DRD4, TH
50norepinephrine45 24 1110.6DRD2, DRD3, DRD4, TH

GO Terms for genes affiliated with Delusional Disorder

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16Gene Ontology
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Cellular components related to Delusional Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:0431979.4DRD2, DRD4
2endocytic vesicleGO:0301399.4DRD3, DRD2
3terminal boutonGO:0431959.3DRD4, TH
4perikaryonGO:0432049.0DRD2, TH
5integral component of plasma membraneGO:0058878.2DRD2, DRD3, DRD4, HLA-A

Biological processes related to Delusional Disorder according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1regulation of locomotion involved in locomotory behaviorGO:0903259.9DRD2, DRD3
2negative regulation of dopamine receptor signaling pathwayGO:0601609.9DRD2, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:0515849.8DRD2, DRD3
4regulation of cAMP metabolic processGO:0308149.8DRD3, DRD2
5G-protein coupled receptor internalizationGO:0020319.8DRD2, DRD3
6prepulse inhibitionGO:0601349.8DRD3, DRD2
7positive regulation of dopamine uptake involved in synaptic transmissionGO:0515869.8DRD2, DRD4
8negative regulation of voltage-gated calcium channel activityGO:19013869.8DRD4, DRD2
9positive regulation of renal sodium excretionGO:0358159.8DRD2, DRD3
10behavioral response to ethanolGO:0481499.7DRD4, DRD2
11response to morphineGO:0432789.7DRD3, DRD2
12response to cocaineGO:0422209.7DRD3, DRD2
13circadian regulation of gene expressionGO:0329229.7DRD3, DRD2
14negative regulation of protein kinase B signalingGO:0518989.6DRD2, DRD3
15response to light stimulusGO:0094169.6DRD2, TH
16negative regulation of blood pressureGO:0457769.6DRD3, DRD2
17pigmentationGO:0434739.6TH, DRD2
18positive regulation of cytokinesisGO:0324679.6DRD2, DRD3
19visual learningGO:0085429.5DRD2, DRD3
20response to histamineGO:0347769.4DRD4, DRD3, DRD2
21adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.4DRD2, DRD3, DRD4
22dopamine metabolic processGO:0424179.4DRD4, DRD3, DRD2
23negative regulation of protein secretionGO:0507099.4DRD2, DRD3, DRD4
24behavioral response to cocaineGO:0481489.4DRD4, DRD3, DRD2
25arachidonic acid secretionGO:0504829.4DRD2, DRD3, DRD4
26negative regulation of adenylate cyclase activityGO:0071949.3DRD2, DRD3, DRD4
27response to hypoxiaGO:0016669.3DRD2, TH
28cellular calcium ion homeostasisGO:0068749.3DRD2, DRD3, DRD4
29learningGO:0076129.3TH, DRD3
30social behaviorGO:0351769.2TH, DRD4, DRD3
31locomotory behaviorGO:0076269.2TH, DRD3, DRD2
32response to ethanolGO:0454719.1DRD3, TH
33synaptic transmission, dopaminergicGO:0019638.8DRD2, DRD3, DRD4, TH
34response to amphetamineGO:0019758.8DRD2, DRD3, DRD4, TH

Molecular functions related to Delusional Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein domain specific bindingGO:0199049.4DRD3, TH
2potassium channel regulator activityGO:0154599.3DRD4, DRD2
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.0DRD2, DRD3, DRD4
4drug bindingGO:0081449.0DRD3, DRD2, DRD4
5dopamine bindingGO:0352408.5TH, DRD4, DRD3, DRD2
6protein bindingGO:0055157.2DRD3, DRD2, TH, HLA-A, DRD4

Products for genes affiliated with Delusional Disorder

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Sources for Delusional Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet