MCID: DLS001
MIFTS: 46

Delusional Disorder malady

Mental diseases category
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Summaries for Delusional Disorder

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Disease Ontology:8 A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.

MalaCards based summary: Delusional Disorder is related to schizophrenia and alcohol dependence. An important gene associated with Delusional Disorder is DRD3 (dopamine receptor D3), and among its related pathways are GPCRs, Other and Hypothetical Network for Drug Addiction. The compounds trans flupenthixol and pd 128907 have been mentioned in the context of this disorder. Affiliated tissues include eye and pituitary, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:65 Delusional disorder is an uncommon psychiatric condition in which the patients present with delusions,... more...

Aliases & Classifications for Delusional Disorder

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Delusional Disorder, Aliases & Descriptions:

Name: Delusional Disorder 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:778
MeSH34 D012563
SNOMED-CT57 192330005, 48500005
ICD9CM27 297.1
ICD1025 F22.0

Related Diseases for Delusional Disorder

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Diseases related to Delusional Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia30.6TH, DRD4, DRD3, DRD2
2alcohol dependence30.3DRD2, DRD4
3personality disorder30.3DRD2, DRD3, DRD4
4alcohol abuse30.3DRD2, DRD3
5schizoaffective disorder30.3DRD4, DRD3, DRD2
6bipolar disorder30.2TH, DRD2
7psychotic disorder29.7DRD2, DRD3, DRD4, TH
8mood disorder29.7DRD2, DRD3, DRD4, TH
9parkinson's disease29.6TH, DRD4, DRD3, DRD2
10myoclonus-dystonia10.4DRD2
11oppositional defiant disorder10.4DRD4
12paranoid schizophrenia10.3
13body dysmorphic disorder10.3
14capgras syndrome10.2
15anorexia nervosa10.2
16dementia10.2
17opiate dependence10.2DRD2, DRD3
18drug dependence10.2DRD2, DRD3
19cocaine dependence10.2DRD2, DRD3
20heroin dependence10.2DRD4, DRD2
21drug addiction10.1DRD3, DRD2
22conduct disorder10.1DRD2, DRD4
23gilles de la tourette syndrome10.1DRD4, DRD2
24nicotine dependence10.1DRD2, DRD4
25progressive supranuclear palsy10.1TH, DRD2
26charcot-marie-tooth disease10.0
27major depressive disorder10.0
28phenylketonuria10.0
29von hippel-lindau disease10.0
30dyslexia10.0
31borderline personality disorder10.0
32pain disorder10.0
33schizophreniform disorder10.0
34social phobia10.0
35cerebritis10.0
36acute orbital inflammation10.0
37cerebrovascular disease10.0
38neuropathy10.0
39peripheral neuropathy10.0
40sleep apnea10.0
41tooth disease10.0
42trimethylaminuria10.0
43argyrophilic grain disease10.0
44attention deficit hyperactivity disorder10.0DRD4, DRD2
45multiple system atrophy10.0DRD2, TH
46pathological gambling10.0DRD4, DRD3, DRD2
47substance dependence10.0DRD4, DRD3, DRD2
48obsessive-compulsive disorder10.0DRD4, DRD3, DRD2
49substance abuse10.0DRD2, DRD3, DRD4
50pheochromocytoma10.0DRD2, TH

Graphical network of the top 20 diseases related to Delusional Disorder:



Diseases related to delusional disorder

Symptoms for Delusional Disorder

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Drugs & Therapeutics for Delusional Disorder

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Drug clinical trials:

Search ClinicalTrials for Delusional Disorder

Search NIH Clinical Center for Delusional Disorder

Genetic Tests for Delusional Disorder

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Anatomical Context for Delusional Disorder

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MalaCards organs/tissues related to Delusional Disorder:

32
Eye, Pituitary

Animal Models for Delusional Disorder or affiliated genes

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MGI Mouse Phenotypes related to Delusional Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.4DRD2, DRD3, DRD4, TH
2MP:00053868.1DRD2, DRD3, DRD4, TH

Publications for Delusional Disorder

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Articles related to Delusional Disorder:

(show top 50)    (show all 151)
idTitleAuthorsYear
1
Sexual Feelings Toward the Therapist Among Patients with Borderline Personality Disorder: A Case of Erotomanic Delusional Disorder. (25391585)
2014
2
Suicidal ideation and suicidal behaviour in delusional disorder: a clinical overview. (24829903)
2014
3
Aripiprazole in difficult-to-treat delusional disorder with co-morbid epilepsy. (24779650)
2014
4
Delusional disorder and oncology: review of the literature and case report. (24066407)
2013
5
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. (24272318)
2013
6
Low-dose quetiapine for the treatment of delusional disorder in a patient with Von Hippel-Lindau disease. (24026746)
2013
7
Comparative efficacy and acceptability of existing pharmacotherapies for delusional disorder: a retrospective case series and review of the literature. (23771191)
2013
8
Delusional disorders--are they simply paranoid schizophrenia? (21078814)
2012
9
Imprisonment, alcohol dependence and risk of delusional disorder: a cross-sectional study. (22608012)
2012
10
Delusional disorder. (22396352)
2012
11
Neuropsychological research in delusional disorder: a comprehensive review. (22269940)
2012
12
Comorbidity of delusional disorder with bipolar disorder: report of four cases. (21652084)
2011
13
Gender differences in delusional disorder: Evidence from an outpatient sample. (20334930)
2010
14
Delusional disorder and alcohol abuse in a patient with Wilson's disease. (19061688)
2008
15
Delusional disorder-jealous type: how inclusive are the DSM-IV diagnostic criteria? (18257054)
2008
16
Serum cholesterol concentrations in suicidal and non-suicidal male patients suffering from persistent delusional disorder. (18405068)
2008
17
Successful treatment of delusional disorder with low-dose aripiprazole. (18588606)
2008
18
Involuntary medication treatment for competency restoration of 22 defendants with delusional disorder. (17389345)
2007
19
Monosymptomatic delusional disorder with delusion of poverty. (16633215)
2006
20
Genetic associations between delusional disorder and paranoid schizophrenia: A novel etiologic approach. (16786814)
2006
21
A hypothetical clinical vignette of delusional disorder: how potential legal issues could be addressed in the United Kingdom and the United States. (16773627)
2006
22
Folie a deux versus genetically driven delusional disorder: case reports and nosological considerations. (14999667)
2004
23
Making psychiatric sense of sand: a case of delusional disorder in Saudi Arabia. (15446724)
2004
24
Stalking behavior - an overview of the problem and a case report of male-to-male stalking during delusional disorder. (12457023)
2002
25
The relationship of olfactory delusional disorder to social phobia. (11838032)
2002
26
Magnetic resonance imaging findings in patients with delusional disorder due to diffuse cerebrovascular disease: a report of seven cases. (11285090)
2001
27
Occurrence and clinical correlates of psychiatric co-morbidity in delusional disorder. (11418272)
2001
28
Delusional disorder: retrospective analysis of 86 Chinese outpatients. (10687749)
1999
29
Effects of pimozide on the psychopathology of delusional disorder. (9608605)
1998
30
Expression and characterization of a dopamine D4R variant associated with delusional disorder. (9489994)
1998
31
Delusional disorder in a boy with phenylketonuria and amine metabolites in the cerebrospinal fluid after treatment with neuroleptics. (9502013)
1998
32
Organic delusional disorder in psychiatric in-patients: comparison with delusional disorder. (9065682)
1997
33
A case of somatic delusional disorder that responded to treatment with risperidone. (9413884)
1997
34
Induced delusional disorder in an adolescent : a case report. (21584103)
1997
35
Capgras syndrome and erotomanic type delusional disorder. (8811277)
1996
36
A clinical and neuropsychological comparison of delusional disorder and schizophrenia. (8854299)
1996
37
Episodic memory deficit in elderly adults with suspected delusional disorder. (8792905)
1996
38
Delusional disorder: the recognition and management of paranoia. (8626368)
1996
39
Drug treatment of schizophrenia and delusional disorder in late life. (9147173)
1996
40
Psychiatric liaison to family medicine. Patient with delusional disorder. (7894287)
1995
41
Quantitative magnetic resonance imaging volumetry distinguishes delusional disorder from late-onset schizophrenia. (7804661)
1994
42
Clinical characteristics of late-onset schizophrenia and delusional disorder. (8303221)
1993
43
Delusional disorder and mood disorder: can they coexist? (8321893)
1993
44
Smooth pursuit eye movements and saccadic eye movements in patients with delusional disorder. (8352354)
1993
45
Delusional disorder: the predictive validity of the concept. (1683095)
1991
46
A delusional disorder that occurred in one of a pair of monozygotic twins. (2096235)
1990
47
Clomipramine treatment of delusional disorder-somatic type. (3360722)
1988
48
Long-term course and outcome in delusional disorder. (3232535)
1988
49
Toward an operationalization of reactive paranoid psychoses (reactive delusional disorder). (3423171)
1987
50
Delusional disorder (paranoia). (923223)
1977

Variations for Delusional Disorder

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Expression for genes affiliated with Delusional Disorder

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Expression patterns in normal tissues for genes affiliated with Delusional Disorder

Search GEO for disease gene expression data for Delusional Disorder.

Pathways for genes affiliated with Delusional Disorder

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Pathways related to Delusional Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5DRD3, DRD4
29.4DRD2, DRD4
3
Show member pathways
9.3DRD2, TH
4
Show member pathways
9.0DRD4, DRD3, DRD2
5
Show member pathways
9.0DRD2, DRD3, DRD4
6
Show member pathways
9.0DRD4, DRD3, DRD2
79.0DRD4, DRD3, DRD2
8
Show member pathways
Nicotine Activity on Dopaminergic Neurons37
8.4DRD2, DRD3, DRD4, TH
9
Show member pathways
8.4DRD2, DRD3, DRD4, TH

Compounds for genes affiliated with Delusional Disorder

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Compounds related to Delusional Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1trans flupenthixol289.6DRD2, DRD3
2pd 12890728 4410.6DRD3, DRD2
3(+)-uh232289.5DRD3, DRD2
4[3h]nemonapride289.5DRD3, DRD2
5(-)-sulpiride289.4DRD4, DRD3, DRD2
6(+)-sulpiride289.4DRD4, DRD3, DRD2
7eticlopride44 2810.4DRD2, DRD3, DRD4
8nemonapride44 50 2811.4DRD2, DRD3, DRD4
9(+)-butaclamol44 2810.4DRD4, DRD3, DRD2
10sch 23390449.4DRD4, DRD3, DRD2
117-oh-dpat289.4DRD3, DRD2
12remoxipride44 1110.4DRD4, DRD3, DRD2
13piribedil28 4410.4DRD2, DRD3, DRD4
14benzamide2 4410.4DRD2, DRD3, DRD4
15rotigotine28 44 1111.4DRD4, DRD3, DRD2
16raclopride44 2810.4DRD4, DRD3, DRD2
17roxindole28 4410.4DRD2, DRD3, DRD4
18terguride44 2810.4DRD4, DRD3, DRD2
19spiperone44 2810.4DRD4, DRD3, DRD2
20piperazine44 1110.4DRD4, DRD3, DRD2
21sulpiride44 28 1111.3DRD4, DRD3, DRD2
22ropinirole44 1110.3DRD4, DRD3, DRD2
23lisuride44 28 1111.3DRD2, DRD3, DRD4
24paliperidone44 1110.3DRD4, DRD3, DRD2
25pergolide44 28 1111.3DRD4, DRD3, DRD2
26iloperidone50 44 28 1112.3DRD4, DRD3, DRD2
27asenapine28 1110.3DRD4, DRD3, DRD2
28cabergoline44 28 1111.3DRD2, DRD3, DRD4
29heroin44 50 1111.2DRD4, DRD3, DRD2
30aripiprazole28 44 50 24 1113.2DRD2, DRD3, DRD4
31domperidone44 28 1111.2DRD2, DRD3, TH
32ziprasidone28 50 44 1112.2DRD4, DRD3, DRD2
33(-)-n-porphynorapomorphine289.2DRD3, DRD2
34chlorpromazine28 44 50 1112.2DRD4, DRD3, DRD2
35methylphenidate44 50 1111.2TH, DRD4, DRD2
36bromocriptine44 28 1111.2DRD4, DRD3, DRD2
37maoa449.2TH, DRD4, DRD2
38risperidone44 50 28 61 24 1114.1DRD4, DRD3, DRD2
39pramipexole44 28 50 1111.8DRD2, DRD3, DRD4, TH
40quinpirole44 289.8TH, DRD4, DRD3, DRD2
41apomorphine28 44 1110.8TH, DRD4, DRD3, DRD2
42quetiapine44 50 28 24 1112.8TH, DRD4, DRD3, DRD2
43methamphetamine44 50 1110.8TH, DRD4, DRD3, DRD2
446-hydroxydopamine448.8TH, DRD4, DRD3, DRD2
45levodopa44 119.8TH, DRD4, DRD3, DRD2
46clozapine44 28 50 1111.8TH, DRD4, DRD3, DRD2
47haloperidol44 50 28 2 1112.7TH, DRD4, DRD3, DRD2
48cocaine44 119.7TH, DRD4, DRD3, DRD2
49nicotine44 28 50 1111.7DRD2, DRD3, DRD4, TH
50norepinephrine44 24 1110.6DRD2, DRD3, DRD4, TH

GO Terms for genes affiliated with Delusional Disorder

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Cellular components related to Delusional Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:0431979.4DRD2, DRD4
2endocytic vesicleGO:0301399.4DRD3, DRD2
3terminal boutonGO:0431959.3DRD4, TH
4perikaryonGO:0432049.0DRD2, TH
5integral component of plasma membraneGO:0058878.2DRD2, DRD3, DRD4, HLA-A

Biological processes related to Delusional Disorder according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1regulation of locomotion involved in locomotory behaviorGO:0903259.9DRD2, DRD3
2negative regulation of dopamine receptor signaling pathwayGO:0601609.9DRD2, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:0515849.8DRD2, DRD3
4regulation of cAMP metabolic processGO:0308149.8DRD3, DRD2
5G-protein coupled receptor internalizationGO:0020319.8DRD2, DRD3
6prepulse inhibitionGO:0601349.8DRD3, DRD2
7positive regulation of dopamine uptake involved in synaptic transmissionGO:0515869.8DRD2, DRD4
8negative regulation of voltage-gated calcium channel activityGO:19013869.8DRD4, DRD2
9positive regulation of renal sodium excretionGO:0358159.8DRD2, DRD3
10behavioral response to ethanolGO:0481499.7DRD4, DRD2
11response to morphineGO:0432789.7DRD3, DRD2
12response to cocaineGO:0422209.7DRD3, DRD2
13circadian regulation of gene expressionGO:0329229.7DRD3, DRD2
14negative regulation of protein kinase B signalingGO:0518989.6DRD2, DRD3
15response to light stimulusGO:0094169.6DRD2, TH
16negative regulation of blood pressureGO:0457769.6DRD3, DRD2
17pigmentationGO:0434739.6TH, DRD2
18positive regulation of cytokinesisGO:0324679.6DRD2, DRD3
19visual learningGO:0085429.5DRD2, DRD3
20response to histamineGO:0347769.4DRD4, DRD3, DRD2
21adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.4DRD2, DRD3, DRD4
22dopamine metabolic processGO:0424179.4DRD4, DRD3, DRD2
23negative regulation of protein secretionGO:0507099.4DRD2, DRD3, DRD4
24behavioral response to cocaineGO:0481489.4DRD4, DRD3, DRD2
25arachidonic acid secretionGO:0504829.4DRD2, DRD3, DRD4
26negative regulation of adenylate cyclase activityGO:0071949.3DRD2, DRD3, DRD4
27response to hypoxiaGO:0016669.3DRD2, TH
28cellular calcium ion homeostasisGO:0068749.3DRD2, DRD3, DRD4
29learningGO:0076129.3TH, DRD3
30social behaviorGO:0351769.2TH, DRD4, DRD3
31locomotory behaviorGO:0076269.2TH, DRD3, DRD2
32response to ethanolGO:0454719.1DRD3, TH
33synaptic transmission, dopaminergicGO:0019638.8DRD2, DRD3, DRD4, TH
34response to amphetamineGO:0019758.8DRD2, DRD3, DRD4, TH

Molecular functions related to Delusional Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein domain specific bindingGO:0199049.4DRD3, TH
2potassium channel regulator activityGO:0154599.3DRD2, DRD4
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015919.0DRD2, DRD3, DRD4
4drug bindingGO:0081449.0DRD4, DRD3, DRD2
5dopamine bindingGO:0352408.5DRD2, DRD3, DRD4, TH
6protein bindingGO:0055157.2TH, HLA-A, DRD4, DRD3, DRD2

Products for genes affiliated with Delusional Disorder

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Sources for Delusional Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet