MCID: DLS001
MIFTS: 43

Delusional Disorder malady

Neuronal diseases category

Summaries for Delusional Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.

MalaCards: Delusional Disorder is related to schizophrenia and anorexia nervosa. An important gene associated with Delusional Disorder is DRD4 (dopamine receptor D4), and among its related pathways are GPCRs, Other and Hypothetical Network for Drug Addiction. The compounds pd 128907 and (+)-uh232 have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and pituitary.

Wikipedia:63 Delusional disorder is an uncommon psychiatric condition in which patients present with delusions, but... more...

Aliases & Classifications for Delusional Disorder

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

delusional disorder 8 10 60


External Ids:

Disease Ontology8 DOID:778
MeSH34 D012563
SNOMED-CT56 192330005, 48500005
ICD9CM27 297.1
ICD1025 F22.0

Related Diseases for Delusional Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Delusional Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia30.9TH, DRD4, DRD3, DRD2
2anorexia nervosa30.2DRD4
3dementia30.2TH
4personality disorder30.2DRD4, DRD3, DRD2
5schizoaffective disorder30.2DRD4, DRD3, DRD2
6psychotic disorder30.2DRD2, DRD3, DRD4, TH
7panic disorder30.0DRD4
8alcohol dependence29.9DRD2, DRD4
9attention deficit hyperactivity disorder29.9DRD2, DRD4
10bipolar disorder29.9DRD2, TH
11alcohol abuse29.9DRD2, DRD3
12parkinson's disease29.9DRD2, DRD3, TH
13mood disorder29.9DRD2, DRD3, DRD4, TH
14somatization disorder10.7
15paranoid schizophrenia10.4
16body dysmorphic disorder10.3
17capgras syndrome10.1
18major depressive disorder10.0
19schizophreniform disorder10.0
20dyslexia10.0
21social phobia10.0
22cerebritis10.0
23pain disorder10.0
24phenylketonuria10.0
25von hippel-lindau disease10.0
26acute orbital inflammation10.0
27cerebrovascular disease10.0
28charcot-marie-tooth disease10.0
29eating disorder10.0
30neuropathy10.0
31peripheral neuropathy10.0
32physical disorder10.0
33sleep disorder10.0
34tooth disease10.0
35myoclonus-dystonia10.0DRD2
36restless legs syndrome10.0DRD2
37hypertension10.0TH
38neuroblastoma10.0TH
39rett syndrome10.0TH
40addison's disease10.0TH
41nicotine dependence10.0DRD4, DRD2
42paraganglioma10.0TH
43cocaine dependence10.0DRD3, DRD2
44opiate dependence10.0DRD3, DRD2
45heroin dependence10.0DRD4, DRD2
46drug addiction10.0DRD3, DRD2
47gilles de la tourette syndrome10.0DRD4, DRD2
48conduct disorder10.0DRD4, DRD2
49drug dependence10.0DRD3, DRD2
50progressive supranuclear palsy10.0TH, DRD2

Graphical network of the top 20 diseases related to Delusional Disorder:



Diseases related to delusional disorder

Clinical Features for Delusional Disorder

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Drugs & Therapeutics for Delusional Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Delusional Disorder

Drug clinical trials:

Search ClinicalTrials for Delusional Disorder

Search NIH Clinical Center for Delusional Disorder

Search CenterWatch for Delusional Disorder

Genetic Tests for Delusional Disorder

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Anatomical Context for Delusional Disorder

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32MalaCards
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MalaCards organs/tissues related to Delusional Disorder:

32
Eye, Skin, Pituitary

Animal Models for Delusional Disorder or affiliated genes

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Publications for Delusional Disorder

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Sources:
50PubMed
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Articles related to Delusional Disorder:

(show top 50)    (show all 162)
idTitleAuthorsYear
1
Delusional Disorder as a Partial Psychosis. (24421383)
2014
2
Delusional disorder and oncology: review of the literature and case report. (24066407)
2013
3
Insight impairment in body image disorders: delusionality and overvalued ideas in anorexia nervosa versus body dysmorphic disorder. (23992792)
2013
4
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. (24272318)
2013
5
Effectiveness of low-dose milnacipran for a patient suffering from pain disorder with delusional disorder (somatic type) in the orofacial region. (23909967)
2013
6
Prevalence of premorbid personality disorder and its clinical correlates in patients with delusional disorder. (23993136)
2013
7
Monosymptomatic Hypochondriacal Psychosis (somatic delusional disorder): a report of two cases. (23595526)
2013
8
Delayed-onset post-stroke delusional disorder: a case report. (23619082)
2013
9
Delusional misidentification syndromes in obsessive-compulsive disorder. (22922811)
2013
10
Neuropsychological research in delusional disorder: a comprehensive review. (22269940)
2012
11
The clinical and sociodemographic profile of persistent delusional disorder. (22441422)
2012
12
Delusional-like experiences are more common in those with cannabis dependence disorder, very early-onset alcohol use or dependence disorders, and daily smokers. (22466088)
2012
13
Delusional versus nondelusional body dysmorphic disorder. (20152299)
2010
14
An examination of delusional thinking and cognitive styles in body dysmorphic disorder. (20636191)
2010
15
An empirical study of psychosocial and clinical correlates of delusional disorder: the DELIREMP study. (23034241)
2009
16
Neuropsychological profile of delusional disorder. (19556944)
2009
17
Delusional disorder-jealous type: how inclusive are the DSM-IV diagnostic criteria? (18257054)
2008
18
Serum cholesterol concentrations in suicidal and non-suicidal male patients suffering from persistent delusional disorder. (18405068)
2008
19
Delusional disorder, somatic type treated with aripiprazole--mirtazapine combination. (18308798)
2008
20
Delusional disorder: Study from North India. (17875023)
2007
21
Treating delusional disorder: a comparison of cognitive-behavioural therapy and attention placebo control. (17479527)
2007
22
A hypothetical clinical vignette of delusional disorder: how potential legal issues could be addressed in the United Kingdom and the United States. (16773627)
2006
23
Wilson's disease associated with delusional disorder. (17109711)
2006
24
Genetics and delusional disorder. (16705657)
2006
25
Body dysmorphic disorder, dysmorphophobia or delusional disorder-somatic subtype? (20703349)
2006
26
The application of civil commitment law and practices to a case of delusional disorder: a cross-national comparison of legal approaches in the United States and the United Kingdom. (16773626)
2006
27
Delusional disorder and the law. (15803048)
2005
28
Folie a deux versus genetically driven delusional disorder: case reports and nosological considerations. (14999667)
2004
29
Making psychiatric sense of sand: a case of delusional disorder in Saudi Arabia. (15446724)
2004
30
Impairment in visual and spatial perception in schizophrenia and delusional disorder. (15261715)
2004
31
The relationship of olfactory delusional disorder to social phobia. (11838032)
2002
32
Body dysmorphic disorder in patients with anorexia nervosa: prevalence, clinical features, and delusionality of body image. (12210643)
2002
33
Magnetic resonance imaging findings in patients with delusional disorder due to diffuse cerebrovascular disease: a report of seven cases. (11285090)
2001
34
Near-fatal skin picking from delusional body dysmorphic disorder responsive to fluvoxamine. (9989126)
1999
35
Negative symptoms due to sleep apnea syndrome in a patient with a delusional disorder. (10572369)
1999
36
Dopamine receptor D4 gene is associated with delusional symptomatology in mood disorders. (9754691)
1998
37
Organic delusional disorder in psychiatric in-patients: comparison with delusional disorder. (9065682)
1997
38
Ondansetron, a 5-HT3 antagonist for visual hallucinations and paranoid delusional disorder associated with chronic L-DOPA therapy in advanced Parkinson's disease. (8615178)
1996
39
Psychiatric liaison to family medicine. Patient with delusional disorder. (7894287)
1995
40
An overview of treatment in paranoia/delusional disorder. (8681259)
1995
41
Quantitative magnetic resonance imaging volumetry distinguishes delusional disorder from late-onset schizophrenia. (7804661)
1994
42
Familial delusional disorder linked with dyslexia. (1571775)
1992
43
A delusional disorder that occurred in one of a pair of monozygotic twins. (2096235)
1990
44
Dysmorphophobia: body dysmorphic disorder or delusional disorder, somatic subtype? (2684497)
1989
45
Delusional parasitosis. A comparative study to late-onset schizophrenia and organic mental disorders due to cerebral arteriosclerosis. (3237953)
1988
46
Long-term course and outcome in delusional disorder. (3232535)
1988
47
Delusional disorder in mother and daughter: case report. (3197010)
1988
48
Delusional disorder: jealous and nonjealous types. (3383924)
1988
49
Paranoid psychosis (delusional disorder) and schizophrenia. A family history study. (7235856)
1981
50
Delusional disorder (paranoia). (923223)
1977

Genetic Variations for Delusional Disorder

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Expression for genes affiliated with Delusional Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Delusional Disorder

Search GEO for disease gene expression data for Delusional Disorder.

Pathways for genes affiliated with Delusional Disorder

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Sources:
37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 53Reactome, 49PharmGKB
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Compounds for genes affiliated with Delusional Disorder

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 2BitterDB, 24HMDB, 59Tocris Bioscience
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Compounds related to Delusional Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1pd 12890744 2810.6DRD3, DRD2
2(+)-uh232289.6DRD2, DRD3
3quinelorane289.5DRD3, DRD2
4(+)-s-14297289.5DRD3, DRD2
57-trans-oh-pipat289.4DRD2, DRD3
6[3h]nemonapride289.4DRD2, DRD3
7(-)-sulpiride289.4DRD3, DRD2, DRD4
8(+)-sulpiride289.4DRD4, DRD3, DRD2
9eticlopride28 4410.4DRD3, DRD2, DRD4
10nemonapride49 44 2811.4DRD4, DRD2, DRD3
11sch 23390449.4DRD2, DRD4, DRD3
12(+)-butaclamol28 4410.4DRD4, DRD3, DRD2
13remoxipride44 1110.4DRD2, DRD4, DRD3
14piribedil28 4410.4DRD2, DRD4, DRD3
15benzamide44 210.4DRD3, DRD4, DRD2
16rotigotine44 28 1111.4DRD4, DRD2, DRD3
17raclopride44 2810.4DRD2, DRD3, DRD4
18roxindole28 4410.4DRD4, DRD3, DRD2
19terguride28 4410.4DRD3, DRD2, DRD4
20spiperone28 4410.4DRD4, DRD3, DRD2
21piperazine44 1110.4DRD3, DRD2, DRD4
22sulpiride44 28 1111.3DRD3, DRD2, DRD4
237-oh-dpat289.3DRD2, DRD3
24ropinirole44 1110.3DRD3, DRD4, DRD2
25lisuride28 44 1111.3DRD2, DRD3, DRD4
26pergolide28 44 1111.3DRD4, DRD3, DRD2
27paliperidone44 1110.3DRD4, DRD3, DRD2
28iloperidone49 44 28 1112.3DRD2, DRD4, DRD3
29Methotrimeprazine119.3DRD2, DRD3, DRD4
30asenapine28 1110.3DRD3, DRD2, DRD4
31cabergoline28 44 1111.2DRD3, DRD2, DRD4
32methylphenidate44 49 1111.2TH, DRD4, DRD2
33heroin44 49 1111.2DRD3, DRD2, DRD4
34maoa449.2DRD2, TH, DRD4
35aripiprazole28 49 44 11 2413.2DRD2, DRD4, DRD3
36ziprasidone49 28 44 1112.2DRD4, DRD2, DRD3
37risperidone28 44 49 59 11 2414.2DRD4, DRD2, DRD3
38domperidone44 28 1111.2TH, DRD3, DRD2
39(-)-n-porphynorapomorphine289.1DRD2, DRD3
40pramipexole44 49 28 1111.8DRD2, DRD3, DRD4, TH
41quinpirole44 289.8DRD2, DRD3, DRD4, TH
42apomorphine44 28 1110.8TH, DRD4, DRD3, DRD2
43quetiapine44 49 28 11 2412.8DRD3, DRD4, DRD2, TH
44methamphetamine44 49 1110.8DRD4, DRD2, DRD3, TH
456-hydroxydopamine448.8DRD4, DRD3, TH, DRD2
46levodopa44 119.8DRD3, DRD2, TH, DRD4
47clozapine44 28 49 1111.8DRD2, TH, DRD4, DRD3
48haloperidol44 28 2 49 1112.7TH, DRD4, DRD3, DRD2
49cocaine44 119.7DRD2, TH, DRD4, DRD3
50nicotine44 49 28 1111.6DRD4, TH, DRD2, DRD3

GO Terms for genes affiliated with Delusional Disorder

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16Gene Ontology
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Cellular components related to Delusional Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:0431979.5DRD4, DRD2
2terminal boutonGO:0431959.4TH, DRD4
3perikaryonGO:0432049.2DRD2, TH
4endocytic vesicleGO:0301399.1DRD2, DRD3
5integral to plasma membraneGO:0058878.2HLA-A, DRD4, DRD3, DRD2

Biological processes related to Delusional Disorder according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of dopamine uptake involved in synaptic transmissionGO:0515869.8DRD4, DRD2
2negative regulation of voltage-gated calcium channel activityGO:19013869.8DRD4, DRD2
3behavioral response to ethanolGO:0481499.8DRD4, DRD2
4negative regulation of dopamine receptor signaling pathwayGO:0601609.8DRD3, DRD2
5regulation of dopamine uptake involved in synaptic transmissionGO:0515849.7DRD2, DRD3
6regulation of cAMP metabolic processGO:0308149.7DRD3, DRD2
7regulation of dopamine secretionGO:0140599.7DRD2, DRD3
8G-protein coupled receptor internalizationGO:0020319.7DRD3, DRD2
9prepulse inhibitionGO:0601349.7DRD3, DRD2
10positive regulation of renal sodium excretionGO:0358159.7DRD2, DRD3
11circadian regulation of gene expressionGO:0329229.6DRD2, DRD3
12response to cocaineGO:0422209.6DRD3, DRD2
13response to light stimulusGO:0094169.6TH, DRD2
14response to morphineGO:0432789.6DRD3, DRD2
15negative regulation of protein kinase B signaling cascadeGO:0518989.5DRD2, DRD3
16negative regulation of blood pressureGO:0457769.4DRD3, DRD2
17pigmentationGO:0434739.4DRD2, TH
18response to histamineGO:0347769.4DRD2, DRD3, DRD4
19adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.4DRD4, DRD3, DRD2
20dopamine metabolic processGO:0424179.4DRD2, DRD3, DRD4
21negative regulation of protein secretionGO:0507099.4DRD2, DRD3, DRD4
22behavioral response to cocaineGO:0481489.3DRD2, DRD3, DRD4
23arachidonic acid secretionGO:0504829.3DRD2, DRD3, DRD4
24negative regulation of adenylate cyclase activityGO:0071949.3DRD4, DRD3, DRD2
25response to ethanolGO:0454719.3TH, DRD3
26cellular calcium ion homeostasisGO:0068749.3DRD4, DRD3, DRD2
27learningGO:0076129.2DRD3, TH
28social behaviorGO:0351769.2DRD3, DRD4, TH
29locomotory behaviorGO:0076269.1DRD2, DRD3, TH
30visual learningGO:0085429.1DRD3, DRD2
31synaptic transmission, dopaminergicGO:0019638.8TH, DRD4, DRD3, DRD2
32response to amphetamineGO:0019758.7TH, DRD4, DRD3, DRD2

Molecular functions related to Delusional Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel regulator activityGO:0154599.5DRD4, DRD2
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015918.9DRD2, DRD3, DRD4
3drug bindingGO:0081448.7DRD4, DRD3, DRD2
4dopamine bindingGO:0352408.4TH, DRD4, DRD3, DRD2

Products for genes affiliated with Delusional Disorder

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Sources for Delusional Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet