MCID: DLS001
MIFTS: 43

Delusional Disorder malady

Neuronal diseases category

Summaries for Delusional Disorder

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.

MalaCards: Delusional Disorder is related to schizophrenia and anorexia nervosa. An important gene associated with Delusional Disorder is DRD4 (dopamine receptor D4), and among its related pathways are GPCRs, Other and Hypothetical Network for Drug Addiction. The compounds pd 128907 and (+)-uh232 have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and pituitary.

Wikipedia:63 Delusional disorder is an uncommon psychiatric condition in which patients present with delusions, but... more...

Aliases & Classifications for Delusional Disorder

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

delusional disorder 8 10 60


External Ids:

Disease Ontology8 DOID:778
MeSH34 D012563
SNOMED-CT56 192330005, 48500005
ICD9CM27 297.1
ICD1025 F22.0

Related Diseases for Delusional Disorder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Delusional Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia30.9TH, DRD4, DRD3, DRD2
2anorexia nervosa30.2DRD4
3dementia30.2TH
4personality disorder30.2DRD4, DRD3, DRD2
5schizoaffective disorder30.2DRD4, DRD3, DRD2
6psychotic disorder30.2DRD2, DRD3, DRD4, TH
7panic disorder30.0DRD4
8alcohol dependence29.9DRD2, DRD4
9attention deficit hyperactivity disorder29.9DRD2, DRD4
10bipolar disorder29.9DRD2, TH
11alcohol abuse29.9DRD2, DRD3
12parkinson's disease29.9DRD2, DRD3, TH
13mood disorder29.9DRD2, DRD3, DRD4, TH
14somatization disorder10.7
15paranoid schizophrenia10.4
16body dysmorphic disorder10.3
17capgras syndrome10.1
18major depressive disorder10.0
19schizophreniform disorder10.0
20dyslexia10.0
21social phobia10.0
22cerebritis10.0
23pain disorder10.0
24phenylketonuria10.0
25von hippel-lindau disease10.0
26acute orbital inflammation10.0
27cerebrovascular disease10.0
28charcot-marie-tooth disease10.0
29eating disorder10.0
30neuropathy10.0
31peripheral neuropathy10.0
32physical disorder10.0
33sleep disorder10.0
34tooth disease10.0
35myoclonus-dystonia10.0DRD2
36restless legs syndrome10.0DRD2
37hypertension10.0TH
38neuroblastoma10.0TH
39rett syndrome10.0TH
40addison's disease10.0TH
41nicotine dependence10.0DRD4, DRD2
42paraganglioma10.0TH
43cocaine dependence10.0DRD3, DRD2
44opiate dependence10.0DRD3, DRD2
45heroin dependence10.0DRD4, DRD2
46drug addiction10.0DRD3, DRD2
47gilles de la tourette syndrome10.0DRD4, DRD2
48conduct disorder10.0DRD4, DRD2
49drug dependence10.0DRD3, DRD2
50progressive supranuclear palsy10.0TH, DRD2

Graphical network of the top 20 diseases related to Delusional Disorder:



Diseases related to delusional disorder

Clinical Features for Delusional Disorder

About this section

Drugs & Therapeutics for Delusional Disorder

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Delusional Disorder

Drug clinical trials:

Search ClinicalTrials for Delusional Disorder

Search NIH Clinical Center for Delusional Disorder

Search CenterWatch for Delusional Disorder

Genetic Tests for Delusional Disorder

About this section

Anatomical Context for Delusional Disorder

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Delusional Disorder:

32
Eye, Skin, Pituitary

Animal Models for Delusional Disorder or affiliated genes

About this section

Publications for Delusional Disorder

About this section
Sources:
50PubMed
See all sources

Articles related to Delusional Disorder:

(show top 50)    (show all 162)
idTitleAuthorsYear
1
Low-dose quetiapine for the treatment of delusional disorder in a patient with Von Hippel-Lindau disease. (24026746)
2013
2
A descriptive retrospective study of the treatment and outpatient service use in a clinical group of delusional disorder patients. (23490496)
2013
3
Deficits in executive and memory processes in delusional disorder: a case-control study. (23844005)
2013
4
Delusional disorders--are they simply paranoid schizophrenia? (21078814)
2012
5
Imprisonment, alcohol dependence and risk of delusional disorder: a cross-sectional study. (22608012)
2012
6
Delusional disorder. (22396352)
2012
7
Comorbidity of delusional disorder with bipolar disorder: report of four cases. (21652084)
2011
8
Folie A deux and delusional disorder by proxy in a family. (22247734)
2011
9
The social and treatment consequences of a shared delusional disorder in a homeless family. (21637634)
2011
10
Delusional disorder-somatic type (or body dysmorphic disorder) and schizophrenia: a case report. (20454749)
2010
11
Successful treatment by paroxetine of delusional disorder, somatic type, accompanied by severe secondary depression. (19935408)
2010
12
Effectiveness and safety of milnacipran treatment for a patient with delusional disorder, somatic type taking multiple medications for concomitant physical diseases. (20386103)
2010
13
A case of catatonia successfully treated with ziprasidone, in a patient with DSM-IV delusional disorder. (21057243)
2010
14
Machiavellianism and executive functioning in patients with delusional disorder. (20402445)
2010
15
Delusional disorder and alcohol abuse in a patient with Wilson's disease. (19061688)
2008
16
Successful treatment of delusional disorder of the somatic type or "delusional parasitosis" with olanzapine. (18484558)
2008
17
Delusional disorder in old age and the risk of developing dementia: a nationwide register-based study. (18855178)
2008
18
Neuropsychological aspects of delusional disorder. (18652791)
2008
19
Involuntary medication treatment for competency restoration of 22 defendants with delusional disorder. (17389345)
2007
20
Is anorexia nervosa a delusional disorder? An assessment of eating beliefs in anorexia nervosa. (17414681)
2007
21
A sibutramine-induced delusional disorder relapse. (17308238)
2007
22
Social cognition in "pure" delusional disorder. (17354084)
2006
23
Aripiprazole and psychotherapy for delusional disorder, erotomanic type. (15322409)
2004
24
Paroxetine treatment of delusional disorder, somatic type. (15252828)
2004
25
Elderly patients with major depressive disorder and delusional disorder are at increased risk of subsequent dementia. (15204223)
2004
26
Stalking behavior - an overview of the problem and a case report of male-to-male stalking during delusional disorder. (12457023)
2002
27
Sensory acuity and reasoning in delusional disorder. (11994833)
2002
28
Delusional disorder: molecular genetic evidence for dopamine psychosis. (12007750)
2002
29
Sertraline and buspirone in adolescent delusional body dysmorphic disorder. (21407895)
2001
30
Delusionality and response to open-label fluvoxamine in body dysmorphic disorder. (11247107)
2001
31
Paranoid (delusional) disorder associated with tuberothalamic artery territory infarction. (11223666)
2001
32
Clinical characteristics of delusional disorder. (11526819)
2001
33
A case of paranoia with severe consequences. From a historical approach to a multidimensional understanding of chronic delusional disorder. (11244383)
2001
34
Role of hla class-I antigens in delusional disorder. (21407957)
2000
35
Shared psychotic disorder in delusional parasitosis. (9885397)
1999
36
Factor analysis of delusional disorder symptomatology. (10080261)
1999
37
Delusional disorder in a boy with phenylketonuria and amine metabolites in the cerebrospinal fluid after treatment with neuroleptics. (9502013)
1998
38
Schizophrenia and delusional disorder in older age: community prevalence, incidence, comorbidity, and outcome. (9502553)
1998
39
A case of somatic delusional disorder that responded to treatment with risperidone. (9413884)
1997
40
Delusional disorder: the recognition and management of paranoia. (8626368)
1996
41
Treatment of somatic delusional disorder with atypical antipsychotic agents. (8599414)
1996
42
Psychotic disorder caused by a general medical condition, with delusions. Secondary "organic" delusional syndromes. (7659604)
1995
43
Schizophreniform disorder, delusional disorder and psychotic disorder not otherwise specified: clinical features, outcome and familial psychopathology. (7676834)
1995
44
Smooth pursuit eye movements and saccadic eye movements in patients with delusional disorder. (8352354)
1993
45
Insight, overvalued ideation, and delusional thinking in body dysmorphic disorder: theoretical and treatment implications. (8228952)
1993
46
Outcome in delusional disorder in different periods of time. Possible implications for treatment with neuroleptics. (8100636)
1993
47
Delusional disorder and Charcot-Marie-tooth disease. (1522413)
1992
48
Organic delusional disorder on a consultation-liaison psychiatry service. Report and review. (1410211)
1992
49
Toward an operationalization of reactive paranoid psychoses (reactive delusional disorder). (3423171)
1987
50
Familial psychopathology in delusional disorder. (3995937)
1985

Genetic Variations for Delusional Disorder

About this section

Expression for genes affiliated with Delusional Disorder

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Delusional Disorder

Search GEO for disease gene expression data for Delusional Disorder.

Pathways for genes affiliated with Delusional Disorder

About this section
Sources:
37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 53Reactome, 49PharmGKB
See all sources

Compounds for genes affiliated with Delusional Disorder

About this section
Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 2BitterDB, 24HMDB, 59Tocris Bioscience
See all sources

Compounds related to Delusional Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idCompoundScoreTop Affiliating Genes
1pd 12890744 2810.6DRD3, DRD2
2(+)-uh232289.6DRD2, DRD3
3(+)-s-14297289.5DRD3, DRD2
4trans flupenthixol289.5DRD3, DRD2
57-trans-oh-pipat289.4DRD2, DRD3
6[3h]nemonapride289.4DRD2, DRD3
7(-)-sulpiride289.4DRD3, DRD2, DRD4
8(+)-sulpiride289.4DRD4, DRD3, DRD2
9eticlopride28 4410.4DRD3, DRD2, DRD4
10nemonapride49 44 2811.4DRD4, DRD2, DRD3
11sch 23390449.4DRD2, DRD4, DRD3
12(+)-butaclamol28 4410.4DRD4, DRD3, DRD2
13remoxipride44 1110.4DRD2, DRD4, DRD3
14piribedil28 4410.4DRD2, DRD4, DRD3
15benzamide44 210.4DRD3, DRD4, DRD2
16rotigotine44 28 1111.4DRD4, DRD2, DRD3
17raclopride44 2810.4DRD2, DRD3, DRD4
18roxindole28 4410.4DRD4, DRD3, DRD2
19terguride28 4410.4DRD3, DRD2, DRD4
20spiperone28 4410.4DRD4, DRD3, DRD2
21piperazine44 1110.4DRD3, DRD2, DRD4
22sulpiride44 28 1111.3DRD3, DRD2, DRD4
237-oh-dpat289.3DRD2, DRD3
24ropinirole44 1110.3DRD3, DRD4, DRD2
25lisuride28 44 1111.3DRD2, DRD3, DRD4
26pergolide28 44 1111.3DRD4, DRD3, DRD2
27paliperidone44 1110.3DRD4, DRD3, DRD2
28iloperidone49 44 28 1112.3DRD2, DRD4, DRD3
29Methotrimeprazine119.3DRD2, DRD3, DRD4
30asenapine28 1110.3DRD3, DRD2, DRD4
31cabergoline28 44 1111.2DRD3, DRD2, DRD4
32methylphenidate44 49 1111.2TH, DRD4, DRD2
33heroin44 49 1111.2DRD3, DRD2, DRD4
34maoa449.2DRD2, TH, DRD4
35aripiprazole28 49 44 11 2413.2DRD2, DRD4, DRD3
36ziprasidone49 28 44 1112.2DRD4, DRD2, DRD3
37risperidone28 44 49 59 11 2414.2DRD4, DRD2, DRD3
38domperidone44 28 1111.2TH, DRD3, DRD2
39(-)-n-porphynorapomorphine289.1DRD2, DRD3
40pramipexole44 49 28 1111.8DRD2, DRD3, DRD4, TH
41quinpirole44 289.8DRD2, DRD3, DRD4, TH
42apomorphine44 28 1110.8TH, DRD4, DRD3, DRD2
43quetiapine44 49 28 11 2412.8DRD3, DRD4, DRD2, TH
44methamphetamine44 49 1110.8DRD4, DRD2, DRD3, TH
456-hydroxydopamine448.8DRD4, DRD3, TH, DRD2
46levodopa44 119.8DRD3, DRD2, TH, DRD4
47clozapine44 28 49 1111.8DRD2, TH, DRD4, DRD3
48haloperidol44 28 2 49 1112.7TH, DRD4, DRD3, DRD2
49cocaine44 119.7DRD2, TH, DRD4, DRD3
50nicotine44 49 28 1111.6DRD4, TH, DRD2, DRD3

GO Terms for genes affiliated with Delusional Disorder

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Delusional Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:0431979.5DRD4, DRD2
2terminal boutonGO:0431959.4TH, DRD4
3perikaryonGO:0432049.2DRD2, TH
4endocytic vesicleGO:0301399.1DRD2, DRD3
5integral to plasma membraneGO:0058878.2HLA-A, DRD4, DRD3, DRD2

Biological processes related to Delusional Disorder according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of dopamine uptake involved in synaptic transmissionGO:0515869.8DRD4, DRD2
2negative regulation of voltage-gated calcium channel activityGO:19013869.8DRD4, DRD2
3behavioral response to ethanolGO:0481499.8DRD4, DRD2
4negative regulation of dopamine receptor signaling pathwayGO:0601609.8DRD3, DRD2
5regulation of dopamine uptake involved in synaptic transmissionGO:0515849.7DRD2, DRD3
6regulation of cAMP metabolic processGO:0308149.7DRD3, DRD2
7regulation of dopamine secretionGO:0140599.7DRD2, DRD3
8G-protein coupled receptor internalizationGO:0020319.7DRD3, DRD2
9prepulse inhibitionGO:0601349.7DRD3, DRD2
10positive regulation of renal sodium excretionGO:0358159.7DRD2, DRD3
11circadian regulation of gene expressionGO:0329229.6DRD2, DRD3
12response to cocaineGO:0422209.6DRD3, DRD2
13response to light stimulusGO:0094169.6TH, DRD2
14response to morphineGO:0432789.6DRD3, DRD2
15negative regulation of protein kinase B signaling cascadeGO:0518989.5DRD2, DRD3
16negative regulation of blood pressureGO:0457769.4DRD3, DRD2
17pigmentationGO:0434739.4DRD2, TH
18response to histamineGO:0347769.4DRD2, DRD3, DRD4
19adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:0071959.4DRD4, DRD3, DRD2
20dopamine metabolic processGO:0424179.4DRD2, DRD3, DRD4
21negative regulation of protein secretionGO:0507099.4DRD2, DRD3, DRD4
22behavioral response to cocaineGO:0481489.3DRD2, DRD3, DRD4
23arachidonic acid secretionGO:0504829.3DRD2, DRD3, DRD4
24negative regulation of adenylate cyclase activityGO:0071949.3DRD4, DRD3, DRD2
25response to ethanolGO:0454719.3TH, DRD3
26cellular calcium ion homeostasisGO:0068749.3DRD4, DRD3, DRD2
27learningGO:0076129.2DRD3, TH
28social behaviorGO:0351769.2DRD3, DRD4, TH
29locomotory behaviorGO:0076269.1DRD2, DRD3, TH
30visual learningGO:0085429.1DRD3, DRD2
31synaptic transmission, dopaminergicGO:0019638.8TH, DRD4, DRD3, DRD2
32response to amphetamineGO:0019758.7TH, DRD4, DRD3, DRD2

Molecular functions related to Delusional Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel regulator activityGO:0154599.5DRD4, DRD2
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:0015918.9DRD2, DRD3, DRD4
3drug bindingGO:0081448.7DRD4, DRD3, DRD2
4dopamine bindingGO:0352408.4TH, DRD4, DRD3, DRD2

Products for genes affiliated with Delusional Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Delusional Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet