MCID: DLS001
MIFTS: 39

Delusional Disorder malady

Mental diseases category

Aliases & Classifications for Delusional Disorder

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Aliases & Descriptions for Delusional Disorder:

Name: Delusional Disorder 8 10 61


Classifications:



External Ids:

Disease Ontology8 DOID:778
ICD9CM27 297.1
SNOMED-CT56 192330005, 48500005
MeSH33 D012563
ICD1025 F22.0

Summaries for Delusional Disorder

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Disease Ontology:8 A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.

MalaCards based summary: Delusional Disorder is related to schizophrenia and personality disorder. An important gene associated with Delusional Disorder is DRD3 (dopamine receptor D3), and among its related pathways are GPCRs, Other and Hypothetical Network for Drug Addiction. The compounds pd 128907 and trans flupenthixol have been mentioned in the context of this disorder. Affiliated tissues include eye and pituitary, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:64 Delusional disorder is an uncommon psychiatric condition in which the patients present with delusions,... more...

Related Diseases for Delusional Disorder

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Diseases related to Delusional Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1schizophrenia30.6TH, DRD4, DRD3, DRD2
2personality disorder30.3DRD2, DRD3, DRD4
3alcohol abuse30.3DRD2, DRD3
4bipolar disorder30.2DRD2, TH
5alcohol dependence30.0DRD2, DRD3, DRD4
6psychotic disorder29.7DRD2, TH, DRD4, DRD3
7mood disorder29.7DRD4, DRD3, DRD2, TH
8dystonia-11, myoclonic10.4DRD2
9oppositional defiant disorder10.4DRD4
10paranoid schizophrenia10.4
11body dysmorphic disorder10.4
12anorexia nervosa10.2
13capgras syndrome10.2
14dementia10.2
15opioid dependence10.2DRD2, DRD3
16drug dependence10.2DRD3, DRD2
17cocaine dependence10.1DRD3, DRD2
18heroin dependence10.1DRD4, DRD2
19drug addiction10.1DRD3, DRD2
20conduct disorder10.1DRD2, DRD4
21gilles de la tourette syndrome10.1DRD2, DRD4
22nicotine dependence, protection against10.1DRD4, DRD2
23supranuclear palsy, progressive10.1TH, DRD2
24trimethylaminuria10.1
25phenylketonuria10.1
26charcot-marie-tooth disease10.1
27borderline personality disorder10.1
28pain disorder10.1
29schizophreniform disorder10.1
30dyslexia10.1
31social phobia10.1
32cerebritis10.1
33acute orbital inflammation10.1
34cerebrovascular disease10.1
35neuropathy10.1
36peripheral neuropathy10.1
37sleep apnea10.1
38tooth disease10.1
39argyrophilic grain disease10.1
40attention deficit-hyperactivity disorder10.0DRD4, DRD2
41multiple system atrophy10.0DRD2, TH
42pathological gambling10.0DRD2, DRD3, DRD4
43substance dependence10.0DRD4, DRD3, DRD2
44obsessive-compulsive disorder10.0DRD3, DRD4, DRD2
45substance abuse10.0DRD2, DRD3, DRD4
46migraine10.0DRD4, DRD2, DRD3
47pheochromocytoma10.0DRD2, TH
48movement disease9.9DRD2, DRD3, TH
49huntington disease9.9TH, DRD2
50hyperprolactinemia9.9DRD4, TH, DRD2

Graphical network of the top 20 diseases related to Delusional Disorder:



Diseases related to delusional disorder

Symptoms for Delusional Disorder

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Drugs & Therapeutics for Delusional Disorder

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Drug clinical trials:

Search ClinicalTrials for Delusional Disorder

Search NIH Clinical Center for Delusional Disorder

Genetic Tests for Delusional Disorder

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Anatomical Context for Delusional Disorder

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MalaCards organs/tissues related to Delusional Disorder:

31
Eye, Pituitary

Animal Models for Delusional Disorder or affiliated genes

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MGI Mouse Phenotypes related to Delusional Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.4DRD2, DRD3, DRD4, TH
2MP:00053868.1DRD2, DRD3, DRD4, TH

Publications for Delusional Disorder

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Articles related to Delusional Disorder:

(show top 50)    (show all 155)
idTitleAuthorsYear
1
Therapeutic approach to delusional disorder based on psychopathological complexity: proposal for a decision model. (25679132)
2015
2
Sexual Feelings Toward the Therapist Among Patients with Borderline Personality Disorder: A Case of Erotomanic Delusional Disorder. (25391585)
2014
3
Suicidal ideation and suicidal behaviour in delusional disorder: a clinical overview. (24829903)
2014
4
Aripiprazole in difficult-to-treat delusional disorder with co-morbid epilepsy. (24779650)
2014
5
Psy-feld: An Innovative Didactic Using the TV Show Seinfeld to Teach Delusional Disorder Subtypes. (25410045)
2014
6
Supersensitivity psychosis and its response to asenapine in a patient with delusional disorder. (25478273)
2014
7
Delusional disorder and oncology: review of the literature and case report. (24066407)
2013
8
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. (24272318)
2013
9
Low-dose quetiapine for the treatment of delusional disorder in a patient with Von Hippel-Lindau disease. (24026746)
2013
10
Comparative efficacy and acceptability of existing pharmacotherapies for delusional disorder: a retrospective case series and review of the literature. (23771191)
2013
11
Delusional disorders--are they simply paranoid schizophrenia? (21078814)
2012
12
Imprisonment, alcohol dependence and risk of delusional disorder: a cross-sectional study. (22608012)
2012
13
Delusional disorder. (22396352)
2012
14
Comorbidity of delusional disorder with bipolar disorder: report of four cases. (21652084)
2011
15
Gender differences in delusional disorder: Evidence from an outpatient sample. (20334930)
2010
16
Delusional disorder and alcohol abuse in a patient with Wilson's disease. (19061688)
2008
17
Delusional disorder-jealous type: how inclusive are the DSM-IV diagnostic criteria? (18257054)
2008
18
Serum cholesterol concentrations in suicidal and non-suicidal male patients suffering from persistent delusional disorder. (18405068)
2008
19
Successful treatment of delusional disorder with low-dose aripiprazole. (18588606)
2008
20
Involuntary medication treatment for competency restoration of 22 defendants with delusional disorder. (17389345)
2007
21
Monosymptomatic delusional disorder with delusion of poverty. (16633215)
2006
22
Genetic associations between delusional disorder and paranoid schizophrenia: A novel etiologic approach. (16786814)
2006
23
A hypothetical clinical vignette of delusional disorder: how potential legal issues could be addressed in the United Kingdom and the United States. (16773627)
2006
24
Folie a deux versus genetically driven delusional disorder: case reports and nosological considerations. (14999667)
2004
25
Stalking behavior - an overview of the problem and a case report of male-to-male stalking during delusional disorder. (12457023)
2002
26
Magnetic resonance imaging findings in patients with delusional disorder due to diffuse cerebrovascular disease: a report of seven cases. (11285090)
2001
27
Occurrence and clinical correlates of psychiatric co-morbidity in delusional disorder. (11418272)
2001
28
Delusional disorder: retrospective analysis of 86 Chinese outpatients. (10687749)
1999
29
Effects of pimozide on the psychopathology of delusional disorder. (9608605)
1998
30
Expression and characterization of a dopamine D4R variant associated with delusional disorder. (9489994)
1998
31
Delusional disorder in a boy with phenylketonuria and amine metabolites in the cerebrospinal fluid after treatment with neuroleptics. (9502013)
1998
32
Organic delusional disorder in psychiatric in-patients: comparison with delusional disorder. (9065682)
1997
33
A case of somatic delusional disorder that responded to treatment with risperidone. (9413884)
1997
34
Induced delusional disorder in an adolescent : a case report. (21584103)
1997
35
Capgras syndrome and erotomanic type delusional disorder. (8811277)
1996
36
A clinical and neuropsychological comparison of delusional disorder and schizophrenia. (8854299)
1996
37
Episodic memory deficit in elderly adults with suspected delusional disorder. (8792905)
1996
38
Delusional disorder: the recognition and management of paranoia. (8626368)
1996
39
Drug treatment of schizophrenia and delusional disorder in late life. (9147173)
1996
40
Psychiatric liaison to family medicine. Patient with delusional disorder. (7894287)
1995
41
Quantitative magnetic resonance imaging volumetry distinguishes delusional disorder from late-onset schizophrenia. (7804661)
1994
42
Clinical characteristics of late-onset schizophrenia and delusional disorder. (8303221)
1993
43
Delusional disorder and mood disorder: can they coexist? (8321893)
1993
44
Smooth pursuit eye movements and saccadic eye movements in patients with delusional disorder. (8352354)
1993
45
Delusional disorder: the predictive validity of the concept. (1683095)
1991
46
A delusional disorder that occurred in one of a pair of monozygotic twins. (2096235)
1990
47
Clomipramine treatment of delusional disorder-somatic type. (3360722)
1988
48
Long-term course and outcome in delusional disorder. (3232535)
1988
49
Toward an operationalization of reactive paranoid psychoses (reactive delusional disorder). (3423171)
1987
50
Delusional disorder (paranoia). (923223)
1977

Variations for Delusional Disorder

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Expression for genes affiliated with Delusional Disorder

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Search GEO for disease gene expression data for Delusional Disorder.

Pathways for genes affiliated with Delusional Disorder

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Pathways related to Delusional Disorder according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5DRD3, DRD4
29.4DRD2, DRD4
3
Show member pathways
9.3DRD2, TH
4
Show member pathways
9.0DRD4, DRD3, DRD2
5
Show member pathways
9.0DRD2, DRD3, DRD4
6
Show member pathways
9.0DRD4, DRD3, DRD2
79.0DRD4, DRD3, DRD2
8
Show member pathways
Nicotine Activity on Dopaminergic Neurons36
8.4DRD2, DRD3, DRD4, TH
9
Show member pathways
8.4DRD2, DRD3, DRD4, TH

Compounds for genes affiliated with Delusional Disorder

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Compounds related to Delusional Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1pd 12890728 4410.6DRD2, DRD3
2trans flupenthixol289.6DRD2, DRD3
3(+)-uh232289.5DRD3, DRD2
4(-)-n-porphynorapomorphine289.5DRD2, DRD3
5(+)-sulpiride289.4DRD2, DRD3, DRD4
6(-)-sulpiride289.4DRD2, DRD3, DRD4
7eticlopride44 2810.4DRD4, DRD2, DRD3
8nemonapride44 50 2811.4DRD2, DRD3, DRD4
9sch 23390449.4DRD2, DRD3, DRD4
10(+)-butaclamol44 2810.4DRD2, DRD3, DRD4
117-oh-dpat289.4DRD3, DRD2
12remoxipride44 1110.4DRD4, DRD2, DRD3
13piribedil28 4410.4DRD3, DRD2, DRD4
14benzamide1 4410.4DRD3, DRD4, DRD2
15raclopride44 2810.4DRD2, DRD4, DRD3
16rotigotine28 44 1111.4DRD2, DRD4, DRD3
17roxindole28 4410.4DRD2, DRD3, DRD4
18terguride44 2810.4DRD3, DRD2, DRD4
19piperazine44 1110.4DRD3, DRD4, DRD2
20spiperone44 2810.4DRD2, DRD3, DRD4
21sulpiride44 28 1111.3DRD2, DRD3, DRD4
22ropinirole44 1110.3DRD4, DRD3, DRD2
23lisuride44 28 1111.3DRD4, DRD3, DRD2
24paliperidone44 1110.3DRD3, DRD4, DRD2
25pergolide44 28 1111.3DRD4, DRD3, DRD2
26iloperidone50 44 28 1112.3DRD2, DRD4, DRD3
27asenapine28 1110.3DRD2, DRD3, DRD4
28cabergoline44 28 1111.3DRD2, DRD3, DRD4
29heroin44 50 1111.2DRD2, DRD3, DRD4
30aripiprazole28 44 50 24 1113.2DRD3, DRD4, DRD2
31domperidone44 28 1111.2TH, DRD3, DRD2
32ziprasidone28 50 44 1112.2DRD2, DRD3, DRD4
33[3h]nemonapride289.2DRD2, DRD3
34methylphenidate44 50 1111.2TH, DRD4, DRD2
35bromocriptine44 28 1111.2DRD2, DRD3, DRD4
36chlorpromazine28 44 50 1112.2DRD3, DRD2, DRD4
37maoa449.2DRD4, DRD2, TH
38risperidone44 50 28 60 24 1114.1DRD2, DRD4, DRD3
39pramipexole44 28 50 1111.8TH, DRD4, DRD3, DRD2
40quinpirole44 289.8TH, DRD3, DRD2, DRD4
41apomorphine28 44 1110.8DRD2, DRD3, DRD4, TH
42quetiapine44 50 28 24 1112.8TH, DRD4, DRD3, DRD2
43methamphetamine44 50 1110.8DRD3, DRD2, TH, DRD4
446-hydroxydopamine448.8DRD2, DRD3, DRD4, TH
45levodopa44 119.8TH, DRD3, DRD4, DRD2
46clozapine44 28 50 1111.8TH, DRD4, DRD3, DRD2
47haloperidol44 50 28 1 1112.7DRD3, DRD4, TH, DRD2
48cocaine44 119.7DRD4, DRD3, DRD2, TH
49nicotine44 28 50 1111.7DRD3, DRD4, TH, DRD2
50norepinephrine44 24 1110.6DRD4, DRD3, DRD2, TH

GO Terms for genes affiliated with Delusional Disorder

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Cellular components related to Delusional Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendritic spineGO:00431979.4DRD2, DRD4
2endocytic vesicleGO:00301399.4DRD3, DRD2
3terminal boutonGO:00431959.3DRD4, TH
4perikaryonGO:00432049.0DRD2, TH
5integral component of plasma membraneGO:00058878.2DRD2, DRD3, DRD4, HLA-A

Biological processes related to Delusional Disorder according to GeneCards Suite gene sharing:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1regulation of locomotion involved in locomotory behaviorGO:00903259.9DRD3, DRD2
2negative regulation of dopamine receptor signaling pathwayGO:00601609.9DRD3, DRD2
3regulation of dopamine uptake involved in synaptic transmissionGO:00515849.8DRD2, DRD3
4regulation of cAMP metabolic processGO:00308149.8DRD2, DRD3
5G-protein coupled receptor internalizationGO:00020319.8DRD3, DRD2
6positive regulation of dopamine uptake involved in synaptic transmissionGO:00515869.8DRD2, DRD4
7prepulse inhibitionGO:00601349.8DRD2, DRD3
8negative regulation of voltage-gated calcium channel activityGO:019013869.8DRD2, DRD4
9positive regulation of renal sodium excretionGO:00358159.8DRD3, DRD2
10behavioral response to ethanolGO:00481499.7DRD4, DRD2
11response to cocaineGO:00422209.7DRD3, DRD2
12circadian regulation of gene expressionGO:00329229.7DRD2, DRD3
13response to morphineGO:00432789.7DRD2, DRD3
14negative regulation of protein kinase B signalingGO:00518989.6DRD2, DRD3
15response to light stimulusGO:00094169.6TH, DRD2
16negative regulation of blood pressureGO:00457769.6DRD3, DRD2
17pigmentationGO:00434739.6TH, DRD2
18positive regulation of cytokinesisGO:00324679.6DRD3, DRD2
19visual learningGO:00085429.5DRD2, DRD3
20response to histamineGO:00347769.4DRD2, DRD3, DRD4
21adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00071959.4DRD4, DRD3, DRD2
22dopamine metabolic processGO:00424179.4DRD4, DRD3, DRD2
23negative regulation of protein secretionGO:00507099.4DRD4, DRD2, DRD3
24behavioral response to cocaineGO:00481489.4DRD4, DRD2, DRD3
25arachidonic acid secretionGO:00504829.4DRD2, DRD3, DRD4
26negative regulation of adenylate cyclase activityGO:00071949.3DRD4, DRD3, DRD2
27response to hypoxiaGO:00016669.3DRD2, TH
28cellular calcium ion homeostasisGO:00068749.3DRD2, DRD3, DRD4
29learningGO:00076129.3TH, DRD3
30social behaviorGO:00351769.2DRD3, DRD4, TH
31locomotory behaviorGO:00076269.2DRD2, TH, DRD3
32response to ethanolGO:00454719.1TH, DRD3
33synaptic transmission, dopaminergicGO:00019638.8TH, DRD2, DRD3, DRD4
34response to amphetamineGO:00019758.8TH, DRD4, DRD3, DRD2

Molecular functions related to Delusional Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein domain specific bindingGO:00199049.4DRD3, TH
2potassium channel regulator activityGO:00154599.3DRD2, DRD4
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00015919.0DRD2, DRD3, DRD4
4drug bindingGO:00081449.0DRD4, DRD3, DRD2
5dopamine bindingGO:00352408.5DRD2, DRD3, DRD4, TH
6protein bindingGO:00055157.2TH, HLA-A, DRD4, DRD3, DRD2

Sources for Delusional Disorder

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet