MCID: DLS001
MIFTS: 41

Delusional Disorder

Categories: Mental diseases

Aliases & Classifications for Delusional Disorder

MalaCards integrated aliases for Delusional Disorder:

Name: Delusional Disorder 12 72 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:778
ICD10 32 F22 F22.0
ICD9CM 34 297.1
MeSH 41 D012563
NCIt 46 C94379
SNOMED-CT 64 192330005 48500005
UMLS 69 C0011251

Summaries for Delusional Disorder

Disease Ontology : 12 A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect.

MalaCards based summary : Delusional Disorder is related to schizoaffective disorder and schizophrenia. An important gene associated with Delusional Disorder is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Beta-Adrenergic Signaling and Circadian entrainment. The drugs Dopamine and Ziprasidone have been mentioned in the context of this disorder. Affiliated tissues include eye, pituitary and brain.

Wikipedia : 72 Delusional disorder is a mental illness in which the patient presents delusions, but with no... more...

Related Diseases for Delusional Disorder

Diseases related to Delusional Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 schizoaffective disorder 30.7 DRD2 DRD3
2 schizophrenia 30.4 DRD2 DRD3 DRD4 TH
3 personality disorder 29.5 DRD2 DRD3 DRD4
4 alcohol abuse 29.3 DRD2 DRD3 DRD4
5 mood disorder 29.2 DRD2 DRD4 TH
6 major depressive disorder 29.2 DRD2 DRD3 DRD4
7 alcohol dependence 29.2 DRD2 DRD3 DRD4
8 early-onset schizophrenia 29.1 DRD2 DRD3 DRD4 TH
9 bipolar disorder 28.8 DRD2 DRD3 DRD4 TH
10 psychotic disorder 28.7 DRD2 DRD3 DRD4 HLA-A
11 autism 28.7 DRD2 DRD3 DRD4 TH
12 capgras syndrome 11.2
13 paranoid schizophrenia 10.5
14 polysubstance abuse 10.2 DRD2 DRD3
15 tardive dyskinesia 10.2 DRD2 DRD3
16 cocaine dependence 10.1 DRD2 DRD3
17 dystonia 11, myoclonic 10.1 DRD2 TH
18 multiple system atrophy 1 10.1 DRD2 TH
19 oppositional defiant disorder 10.1 DRD2 DRD4
20 tic disorder 10.0 DRD2 DRD4
21 heroin dependence 10.0 DRD2 DRD4
22 supranuclear palsy, progressive, 1 10.0 DRD2 TH
23 drug dependence 10.0 DRD2 DRD3
24 aging 10.0
25 body dysmorphic disorder 10.0
26 opiate dependence 10.0 DRD2 DRD3 TH
27 movement disease 10.0 DRD2 DRD3 TH
28 restless legs syndrome 9.9 DRD2 DRD3 TH
29 conduct disorder 9.9 DRD2 DRD4
30 separation anxiety disorder 9.9 DRD4 HLA-A
31 schizotypal personality disorder 9.9
32 bulimia nervosa 2 9.9
33 dementia 9.9
34 impulse control disorder 9.8 DRD2 DRD3 DRD4
35 pathological gambling 9.8 DRD2 DRD3 DRD4
36 migraine without aura 9.8 DRD2 DRD3 DRD4
37 substance abuse 9.8 DRD2 DRD3 DRD4
38 substance dependence 9.8 DRD2 DRD3 DRD4
39 disease of mental health 9.8 DRD2 DRD3 DRD4
40 obsessive-compulsive disorder 9.8 DRD2 DRD3 DRD4
41 migraine with or without aura 1 9.8 DRD2 DRD3 DRD4
42 autism spectrum disorder 9.8 DRD2 DRD3 DRD4
43 von hippel-lindau syndrome 9.7
44 corpus callosum, agenesis of 9.7
45 hydrocephalus, normal-pressure 9.7
46 phenylketonuria 9.7
47 cognitive function 1, social 9.7
48 paine syndrome 9.7
49 trimethylaminuria 9.7
50 anxiety 9.7

Comorbidity relations with Delusional Disorder via Phenotypic Disease Network (PDN): (show all 11)


Acute Cystitis Alzheimer Disease
Anxiety Deficiency Anemia
Dysthymic Disorder Hypothyroidism
Major Depressive Disorder Paranoid Personality Disorder
Paranoid Schizophrenia Parkinson Disease, Late-Onset
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Delusional Disorder:



Diseases related to Delusional Disorder

Symptoms & Phenotypes for Delusional Disorder

Drugs & Therapeutics for Delusional Disorder

Drugs for Delusional Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Ziprasidone Approved Phase 4 146939-27-7 60854
3
Cycloserine Approved Phase 4 68-41-7 6234 401
4
Serotonin Phase 4 50-67-9 5202
5 Central Nervous System Depressants Phase 4
6 Serotonin Agents Phase 4
7 Serotonin Antagonists Phase 4
8 Neurotransmitter Agents Phase 4
9 Tranquilizing Agents Phase 4
10 Dopamine Agents Phase 4
11 Dopamine Antagonists Phase 4
12 Psychotropic Drugs Phase 4
13 Antipsychotic Agents Phase 4,Phase 2
14 Renal Agents Phase 4
15 Anti-Bacterial Agents Phase 4
16 Anti-Infective Agents Phase 4
17 Antimetabolites Phase 4
18 Antibiotics, Antitubercular Phase 4
19 Antitubercular Agents Phase 4
20 Quetiapine Fumarate Phase 4 111974-72-2
21
Olanzapine Approved, Investigational 132539-06-1 4585
22
Risperidone Approved, Investigational 106266-06-2 5073
23
Aripiprazole Approved, Investigational 129722-12-9 60795
24
Ethanol Approved 64-17-5 702
25 Tangerine Approved, Nutraceutical
26 Raclopride Investigational 84225-95-6
27 Serotonin Uptake Inhibitors
28 Gastrointestinal Agents
29 Neurotransmitter Uptake Inhibitors
30 Peripheral Nervous System Agents
31 Antiemetics
32 Autonomic Agents
33 Protective Agents
34
Benztropine 86-13-5 6832
35 Muscarinic Antagonists
36 Cholinergic Agents
37 Cholinergic Antagonists
38 Parasympatholytics
39 Dopamine Uptake Inhibitors
40 Antiparkinson Agents

Interventional clinical trials:

(show all 22)

# Name Status NCT ID Phase Drugs
1 A Study of the Efficacy and Safety of Intramuscular Ziprasidone Followed by Oral Ziprasidone for the Treatment of Psychosis Completed NCT00644800 Phase 4 Ziprasidone
2 D-Cycloserine Augmentation of Cognitive Behavioral Therapy for Delusions Recruiting NCT01981759 Phase 4 D-Cycloserine;Placebo
3 Schizophrenic Patients in Integrated Care Terminated NCT00681629 Phase 4 Quetiapine XR
4 Trial of Cognitive Behavioral Therapy for Schizophrenia Unknown status NCT00300651 Phase 3
5 Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset Psychosis Unknown status NCT00465920 Phase 2
6 Pilot-trial of Emotion-focused Cognitive Behavior Therapy for Patients With Schizophrenia Active, not recruiting NCT02787122 Phase 2
7 Cognitive Determinants of Psychoeducation and Information in Psychoses Unknown status NCT00646256
8 Improving Cognitive Function of Aripiprazole in Treating Adolescents and Young Adults With Psychotic Disorder Unknown status NCT00541502
9 Cross-Sectional Iloperidone IVGTT Unknown status NCT01686815
10 Acceptance and Commitment Therapy for Delusions Completed NCT00657631
11 Schizophrenia, Antipsychotic Treatment and the Risk for Diabetes Mellitus Completed NCT00222807
12 Response of Psychiatric Outpatients to the Great East Japan Earthquake Completed NCT01533064
13 Multi-disciplinary Treatment for Patients Experiencing First Episode of Psychosis Completed NCT01216891
14 Minimizing Doses of Antipsychotic Medication in Older Patients With Schizophrenia. Completed NCT00716755 Risperidone/Olanzapine and PET scans
15 Factors of Importance for the Subjective and Objective Burden of Informal Caregivers to Patients With Functional Psychoses - a Descriptive and Comparative Study Completed NCT00670371
16 Vocal Acoustic Biomarkers in Depression Completed NCT00844948
17 Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project Completed NCT02440906
18 Attributional Style and Parkinson's Disease Recruiting NCT03371277
19 Integrated Care in Psychotic Disorders With Severe Mental Illness Recruiting NCT01888627
20 Improving Work Outcome for People With Severe Mental Illness Active, not recruiting NCT01722344
21 Anticholinergic Burden in Schizophrenia Terminated NCT00715377 Benztropine
22 Schizophrenic Patients Taking Part in Integrated Care Program Terminated NCT00617214

Search NIH Clinical Center for Delusional Disorder

Genetic Tests for Delusional Disorder

Anatomical Context for Delusional Disorder

MalaCards organs/tissues related to Delusional Disorder:

38
Eye, Pituitary, Brain, Liver

Publications for Delusional Disorder

Articles related to Delusional Disorder:

(show top 50) (show all 184)
# Title Authors Year
1
The impact of depressive symptoms on the clinical presentation of Persistent Delusional Disorder. ( 29248867 )
2018
2
The comprehensive treatment of delusional disorder. ( 28476504 )
2017
3
Gender Differences in Persistent Delusional Disorder. ( 28515568 )
2017
4
Delusional Disorder, Erotomanic Type, Exacerbated by Social Media Use. ( 28367347 )
2017
5
A Psychopathological Comparison between Delusional Disorder and Schizophrenia. ( 28595494 )
2017
6
TAILOR - tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial. ( 28962668 )
2017
7
Risperidone versus olanzapine in the acute treatment of Persistent Delusional Disorder: A retrospective analysis. ( 28411574 )
2017
8
Delusional Disorder Arising From a CNS Neoplasm. ( 28422607 )
2017
9
Delusional Disorder in a Patient with Corpus Callosum Agenesis. ( 28208982 )
2016
10
Delusional disorder and schizophrenia: a comparative study across multiple domains. ( 27468631 )
2016
11
What is the Evidence for Treating Delusional Disorder? ( 27712246 )
2016
12
Clinical Presentation and Course of Persistent Delusional Disorder: Data From a Tertiary Care Center in India. ( 27247844 )
2016
13
Aripiprazole-induced Hyperprolactinemia in a Young Female with Delusional Disorder. ( 27335526 )
2016
14
Folie a deux and delusional disorder by proxy: an atypical presentation. ( 27245561 )
2016
15
A Systematic Review on the Pharmacological Treatment of Delusional Disorder. ( 27811554 )
2016
16
Structural and functional brain changes in delusional disorder. ( 26382955 )
2016
17
Characteristics and clinical correlates of dimensions of delusional experience in schizophrenia and delusional disorder. ( 27261418 )
2016
18
Antipsychotic response in delusional disorder and schizophrenia: a prospective cohort study. ( 27388104 )
2016
19
Letter to the Editor: Comparing delusional disorder and schizophrenia: a comment on Hui et al. (2015). ( 26690961 )
2016
20
Treatments for Delusional Disorder. ( 26209547 )
2015
21
Letter to the Editor: Comparing delusional disorder and schizophrenia: a comment on Hui et al. (2015) - a reply. ( 26691196 )
2015
22
Unexpected subthreshold autism spectrum in a 25-year-old male stalker hospitalized for delusional disorder: a case report. ( 26031384 )
2015
23
Normal pressure hydrocephalus presenting as delusional disorder. ( 26257493 )
2015
24
Paranoid delusional disorder follows social anxiety disorder in a long-term case series: evolutionary perspective. ( 26034873 )
2015
25
Therapeutic approach to delusional disorder based on psychopathological complexity: proposal for a decision model. ( 25679132 )
2015
26
The prevalence of delusional disorder in prison. ( 25770283 )
2015
27
A dimensional comparison between delusional disorder, schizophrenia and schizoaffective disorder. ( 26585220 )
2015
28
Treatments for delusional disorder. ( 25997589 )
2015
29
Delusional Disorder over the Reproductive Life Span: The Potential Influence of Menopause on the Clinical Course. ( 26600949 )
2015
30
Delusional disorder and schizophrenia: a comparison of the neurocognitive and clinical characteristics in first-episode patients. ( 26036591 )
2015
31
Sexual Feelings Toward the Therapist Among Patients with Borderline Personality Disorder: A Case of Erotomanic Delusional Disorder. ( 25391585 )
2014
32
Psy-feld: An Innovative Didactic Using the TV Show Seinfeld to Teach Delusional Disorder Subtypes. ( 25410045 )
2014
33
Suicidal ideation and suicidal behaviour in delusional disorder: a clinical overview. ( 24829903 )
2014
34
Russell's sign in persistent delusional disorder: a case report. ( 25093783 )
2014
35
Atypical delusional content in a case of persistent delusional disorder: freud revisited. ( 25336780 )
2014
36
Delusional disorder: an unusual presentation. ( 25336783 )
2014
37
Delusional Disorder as a Partial Psychosis. ( 24421383 )
2014
38
Phenotypic cognitive impairment in late-onset delusional disorder. ( 24524668 )
2014
39
Supersensitivity psychosis and its response to asenapine in a patient with delusional disorder. ( 25478273 )
2014
40
Delusional disorder: no gender differences in age at onset, suicidal ideation, or suicidal behavior. ( 24554277 )
2014
41
Aripiprazole in difficult-to-treat delusional disorder with co-morbid epilepsy. ( 24779650 )
2014
42
Effectiveness of low-dose milnacipran for a patient suffering from pain disorder with delusional disorder (somatic type) in the orofacial region. ( 23909967 )
2013
43
Delusional disorder and oncology: review of the literature and case report. ( 24066407 )
2013
44
Comparative efficacy and acceptability of existing pharmacotherapies for delusional disorder: a retrospective case series and review of the literature. ( 23771191 )
2013
45
Deficits in executive and memory processes in delusional disorder: a case-control study. ( 23844005 )
2013
46
Delusional disorder, somatic type: olfactory reference syndrome in a patient with delusional trimethylaminuria. ( 23719328 )
2013
47
Empirical redefinition of delusional disorder and its phenomenology: the DELIREMP study. ( 23021895 )
2013
48
Low-dose quetiapine for the treatment of delusional disorder in a patient with Von Hippel-Lindau disease. ( 24026746 )
2013
49
Monosymptomatic Hypochondriacal Psychosis (somatic delusional disorder): a report of two cases. ( 23595526 )
2013
50
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. ( 24272318 )
2013

Variations for Delusional Disorder

Expression for Delusional Disorder

Search GEO for disease gene expression data for Delusional Disorder.

Pathways for Delusional Disorder

GO Terms for Delusional Disorder

Cellular components related to Delusional Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle GO:0030139 8.62 DRD2 DRD3

Biological processes related to Delusional Disorder according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.87 DRD2 DRD3 PNP TH
2 response to ethanol GO:0045471 9.77 DRD2 DRD3 TH
3 locomotory behavior GO:0007626 9.76 DRD2 DRD3 TH
4 social behavior GO:0035176 9.72 DRD3 DRD4 TH
5 learning GO:0007612 9.67 DRD3 TH
6 negative regulation of protein kinase B signaling GO:0051898 9.67 DRD2 DRD3
7 circadian regulation of gene expression GO:0032922 9.67 DRD2 DRD3
8 visual learning GO:0008542 9.66 DRD2 DRD3
9 pigmentation GO:0043473 9.66 DRD2 TH
10 response to nicotine GO:0035094 9.65 DRD2 TH
11 response to cocaine GO:0042220 9.65 DRD2 DRD3
12 positive regulation of cytokinesis GO:0032467 9.65 DRD2 DRD3
13 negative regulation of adenylate cyclase activity GO:0007194 9.65 DRD2 DRD3 DRD4
14 negative regulation of blood pressure GO:0045776 9.64 DRD2 DRD3
15 response to morphine GO:0043278 9.64 DRD2 DRD3
16 response to light stimulus GO:0009416 9.63 DRD2 TH
17 regulation of dopamine secretion GO:0014059 9.63 DRD2 DRD3
18 arachidonic acid secretion GO:0050482 9.63 DRD2 DRD3 DRD4
19 behavioral response to ethanol GO:0048149 9.62 DRD2 DRD4
20 negative regulation of voltage-gated calcium channel activity GO:1901386 9.62 DRD2 DRD4
21 prepulse inhibition GO:0060134 9.61 DRD2 DRD3
22 positive regulation of renal sodium excretion GO:0035815 9.61 DRD2 DRD3
23 behavioral response to cocaine GO:0048148 9.61 DRD2 DRD3 DRD4
24 G-protein coupled receptor internalization GO:0002031 9.6 DRD2 DRD3
25 regulation of cAMP metabolic process GO:0030814 9.58 DRD2 DRD3
26 dopamine receptor signaling pathway GO:0007212 9.58 DRD2 DRD3 DRD4
27 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.56 DRD2 DRD3
28 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.54 DRD2 DRD4
29 synaptic transmission, dopaminergic GO:0001963 9.54 DRD2 DRD3 TH
30 negative regulation of dopamine receptor signaling pathway GO:0060160 9.52 DRD2 DRD3
31 acid secretion GO:0046717 9.51 DRD2 DRD3
32 negative regulation of protein secretion GO:0050709 9.5 DRD2 DRD3 DRD4
33 regulation of locomotion involved in locomotory behavior GO:0090325 9.49 DRD2 DRD3
34 dopamine metabolic process GO:0042417 9.43 DRD2 DRD3 DRD4
35 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.33 DRD2 DRD3 DRD4
36 response to histamine GO:0034776 9.13 DRD2 DRD3 DRD4
37 response to amphetamine GO:0001975 8.92 DRD2 DRD3 DRD4 TH

Molecular functions related to Delusional Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.56 DRD2 DRD3 DRD4 PNP
2 signal transducer activity GO:0004871 9.54 DRD2 DRD3 DRD4
3 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.33 DRD2 DRD3 DRD4
4 monooxygenase activity GO:0004497 9.32 FMO3 TH
5 dopamine neurotransmitter receptor activity GO:0004952 9.13 DRD2 DRD3 DRD4
6 dopamine binding GO:0035240 8.92 DRD2 DRD3 DRD4 TH

Sources for Delusional Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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