MCID: DMN002
MIFTS: 66

Dementia malady

Summaries for Dementia

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Dementia is the name for a group of symptoms caused by disorders that affect the brain. it is not a specific disease. people with dementia may not be able to think well enough to do normal activities, such as getting dressed or eating. they may lose their ability to solve problems or control their emotions. their personalities may change. they may become agitated or see things that are not there. memory loss is a common symptom of dementia. however, memory loss by itself does not mean you have dementia. people with dementia have serious problems with two or more brain functions, such as memory and language. although dementia is common in very elderly people, it is not part of normal aging. many different diseases can cause dementia, including alzheimer's disease and stroke. drugs are available to treat some of these diseases. while these drugs cannot cure dementia or repair brain damage, they may improve symptoms or slow down the disease. nih: national institute of neurological disorders and stroke

MalaCards: Dementia is related to frontotemporal dementia and vascular dementia. An important gene associated with Dementia is ITM2B (integral membrane protein 2B), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Neuroscience. The drugs citalopram and prochlorperazine and the compounds serine and glutamine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are behavior/neurological and nervous system.

Disease Ontology:8 A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.

NINDS:43 Dementia is not a specific disease. It is a descriptive term for a collection of symptoms that can be caused by a number of disorders that affect the brain. People with dementia have significantly impaired intellectual functioning that interferes with normal activities and relationships. They also lose their ability to solve problems and maintain emotional control, and they may experience personality changes and behavioral problems, such as agitation, delusions, and hallucinations. While memory loss is a common symptom of dementia, memory loss by itself does not mean that a person has dementia. Doctors diagnose dementia only if two or more brain functions - such as memory and language skills -- are significantly impaired without loss of consciousness.

Wikipedia:63 Dementia (taken from Latin, originally meaning \"madness\", from de- \"without\" + ment, the root of... more...

Aliases & Classifications for Dementia

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8Disease Ontology, 43NINDS, 44Novoseek, 33MedlinePlus, 60UMLS, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

dementia 8 43 44 33 60


External Ids:

Disease Ontology8 DOID:1307
MeSH34 D003704
ICD9CM27 290.8

Related Diseases for Dementia

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17GeneCards, 18GeneDecks
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Diseases related to Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 494)
idRelated DiseaseScoreTop Affiliating Genes
1frontotemporal dementia31.8PSEN1, MAPT
2vascular dementia31.7APOE
3alzheimer's disease31.6ACHE, RPS27A, APP, APOE, PSEN1, CTSB
4lewy body dementia31.5APP, RPS27A, APOE, ACHE, SNCA, MAPT
5parkinson's disease31.2RPS27A, VCP, ACHE, MAPT, ATXN2, SNCA
6amyotrophic lateral sclerosis31.1SNCA, PSEN1, APP, RPS27A, MAPT, VCP
7lateral sclerosis31.0SNCA, MAPT
8motor neuron disease30.9SNCA, VCP, MAPT, GRN, RPS27A
9aphasia30.9C9orf72, GRN, MAPT
10brain disease30.8SERPINI1, SNCA, MAPT, PSEN1, APP
11pick's disease30.8MAPT, PSEN1
12cadasil30.8PSEN1, APOE, MAPT, SERPINI1
13cerebrovascular disease30.7ACHE, APP, APOE
14hydrocephalus30.7MAPT
15progressive supranuclear palsy30.7MAPT, GRN, APOE
16cerebral amyloid angiopathy30.7APOE, PSEN1, ITM2B, APP, MAPT
17tauopathy30.6RPS27A, APP, PSEN1, SNCA, GRN, MAPT
18myopathy30.6RPS27A, APP, ACHE, VCP
19schizophrenia30.6PSEN1, ATN1, SNCA, ACHE
20down syndrome30.5SNCA, PSEN1, ACHE, MAPT, APOE, APP
21multiple system atrophy30.5RPS27A, MAPT, SNCA
22rem sleep behavior disorder30.5SNCA
23binswanger's disease30.5APP, ACHE, APOE
24diabetes mellitus30.4APOE
25semantic dementia30.4RPS27A, GRN, MAPT
26huntington's disease30.3RPS27A, ACHE, SERPINI1, MAPT, ATN1, SNCA
27apraxia30.3GRN, MAPT
28encephalitis30.3APP
29amyloidosis30.2CTSB, APOE, PSEN1, MAPT, RPS27A, ITM2B
30dementia familial british30.2ITM2B, APP, SERPINI1
31prion disease30.2APP, PSEN1, MAPT
32olivopontocerebellar atrophy30.2SNCA, ATXN2
33paget's disease of bone30.2VCP
34ischemia30.1SNCA, PSEN1, SERPINI1, MAPT
35multiple sclerosis30.1APOE
36cerebellar ataxia30.1ATXN2
37alzheimer disease type 230.0MAPT, PSEN1, APOE, APP
38primary progressive aphasia30.0MAPT, GRN, RPS27A
39neuroaxonal dystrophy30.0SNCA, RPS27A
40creutzfeldt-jakob syndrome29.9APOE, SNCA, MAPT, APP, RPS27A
41spinocerebellar ataxia29.9ATXN2
42striatonigral degeneration29.9RPS27A, SNCA
43frontotemporal lobar degeneration with ubiquitin-positive inclusions29.9GRN
44essential tremor29.9SNCA
45glaucoma29.8ACHE
46amyloid tumor29.6MAPT, ACHE, APOE, PSEN1, RPS27A, APP
47astrocytoma29.6SNCA, CTSB, PSEN1, APP
48niemann-pick disease29.6APP, SNCA, MAPT
49dentatorubral-pallidoluysian atrophy29.5ATXN2, ATN1
50neuronal intranuclear inclusion disease29.5RPS27A

Graphical network of the top 20 diseases related to Dementia:



Diseases related to dementia

Clinical Features for Dementia

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Drugs & Therapeutics for Dementia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dementia

Drug clinical trials:

Search ClinicalTrials for Dementia

Search NIH Clinical Center for Dementia

Search CenterWatch for Dementia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Dementia

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Anatomical Context for Dementia

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32MalaCards
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MalaCards organs/tissues related to Dementia:

32
Brain, Cortex, Testes, Bone, Temporal lobe, Heart, Monocytes, Eye, T cells, Endothelial, Skin, Amygdala, Spinal cord, Prefrontal cortex, Thalamus, Caudate nucleus, B cells, Cerebellum, Hypothalamus, Thyroid, Spleen, Parietal lobe, Kidney, Liver, Pituitary

Animal Models for Dementia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Dementia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538612.6SERPINI1, APP, APOE, PSEN1, CTSB, SNCA
2MP:000363112.4SNCA, CTSB, PSEN1, APOE, APP, ITM2B
3MP:001076812.3APP, APOE, PSEN1, CTSB, SNCA, ATXN2
4MP:000537811.9APP, APOE, PSEN1, CTSB, SNCA, ATXN2
5MP:000301211.8APP, APOE, SNCA, ITM2B, ATN1, GRN
6MP:000538411.8APOE, PSEN1, CTSB, SNCA, GRN, TRPM7
7MP:000538911.7APP, APOE, PSEN1, SNCA, ATXN2, ATN1
8MP:000538711.7APP, APOE, PSEN1, CTSB, SNCA, GRN
9MP:000539511.3APP, APOE, PSEN1, CTSB, MAPT
10MP:001077111.2APP, APOE, PSEN1, CTSB, SNCA, MAPT

Publications for Dementia

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Sources:
50PubMed
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Articles related to Dementia:

(show top 50)    (show all 4239)
idTitleAuthorsYear
1
Functional Decline Predicts Emergency Department Use in Veterans With Dementia. (24413540)
2014
2
Severity of Dementia, Anosognosia, and Depression in Relation to the Quality of Life of Patients with Alzheimer Disease: Discrepancies Between Patients andA Caregivers. (23567444)
2014
3
Time to reinvent the science of dementia: the need for care and social integration. (24180580)
2013
4
The feasibility of measuring social networks among older adults in assisted living and dementia special care units. (24339099)
2013
5
Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats. (24337945)
2013
6
APOE I/4 increases risk for dementia in pure synucleinopathies. (23407718)
2013
7
Gray matter contamination in arterial spin labeling white matter perfusion measurements in patients with dementia. (24371796)
2013
8
Cost-effectiveness of one year dementia follow-up care by memory clinics or general practitioners: economic evaluation of a randomised controlled trial. (24282511)
2013
9
Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer's disease and vascular dementia. (23740535)
2013
10
Applicability of the single-case methodology in a patient with dementia with Lewy bodies. (24402220)
2013
11
Using the revised diagnostic criteria for frontotemporal dementia in India: evidence of an advanced and florid disease. (23596513)
2013
12
Vascular lesions in mixed dementia, vascular dementia, and Alzheimer disease with cerebrovascular disease: the Kurihara Project. (22871542)
2012
13
Behaviour and biomarkers in frontotemporal dementia: implications for general psychiatry. (22535297)
2012
14
Definite behavioral variant of frontotemporal dementia with C9ORF72 expansions despite positive Alzheimer's disease cerebrospinal fluid biomarkers. (22766732)
2012
15
The "closing-in" phenomenon in Parkinson's disease dementia and lewy-body dementia. (23224479)
2012
16
Subventricular zone in motor neuron disease with frontotemporal dementia. (21616125)
2011
17
Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias. (21709373)
2011
18
Dementia: progress in diagnosis and treatment; Topics, V. Recent topics; 4. Detection of novel dementia-related genes; 2) Dysregulation of TGF-beta family signaling and hereditary cerebral small vessel disease: insight into molecular pathogenesis of CARASIL]. (21899153)
2011
19
Normal cognitive decline or dementia? (20198932)
2010
20
Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. (21092856)
2010
21
Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementia. (20668259)
2010
22
The impact of dementia and mild memory impairment (MMI) on intimacy and sexuality in spousal relationships. (20226112)
2010
23
Pain perception and tolerance in patients with frontotemporal dementia. (20934811)
2010
24
Neuropathological similarities and differences between frontotemporal lobar degeneration with ubiquitin inclusions and amyotrophic lateral sclerosis with dementia]. (19938689)
2009
25
Differences in coated-platelet production between frontotemporal dementia and Alzheimer disease. (19812465)
2009
26
Effects of music therapy on autonomic nervous system activity, incidence of heart failure events, and plasma cytokine and catecholamine levels in elderly patients with cerebrovascular disease and dementia. (19246850)
2009
27
Determinants of survival in behavioral variant frontotemporal dementia. (19917988)
2009
28
Clinical entity of frontotemporal dementia with motor neuron disease. (19780984)
2009
29
Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia. (18413475)
2008
30
The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia. (18631256)
2008
31
Novel PRNP mutation in a patient with a slow progressive dementia syndrome. (18443555)
2008
32
Phosphorylated Smad 2/3 colocalizes with phospho-tau inclusions in Pick disease, progressive supranuclear palsy, and corticobasal degeneration but not with alpha-synuclein inclusions in multiple system atrophy or dementia with Lewy bodies. (17984683)
2007
33
Drugs for vascular dementia. (17706553)
2007
34
The gene encoding transforming growth factor beta 1 confers risk of ischemic stroke and vascular dementia. (16990569)
2006
35
Mild cognitive impairment subtypes and vascular dementia. (17198525)
2006
36
The age gap between patients in clinical studies and in the general population: a pitfall for dementia research. (15380160)
2004
37
Homocysteinemia in psychiatric disorders: association with dementia and depression, but not schizophrenia in female patients. (14666412)
2003
38
Motor neuron disease presenting with slow saccades and dementia. (12495578)
2002
39
Dementia and statins. (11265975)
2001
40
White matter damage is associated with matrix metalloproteinases in vascular dementia. (11340226)
2001
41
Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies. (11045667)
2000
42
A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto) (10762152)
2000
43
Dysgraphia in mild dementia of Alzheimer's type. (9106281)
1997
44
Relapsing polychondritis with dementia. (9081972)
1995
45
Appearance of localized immunoreactivity for the alpha 4 integrin subunit and for fibronectin in brains from Alzheimer's, Lewy body dementia patients and aged controls. (8041517)
1994
46
Reversible dementia caused by vitamin B12 deficiency. (8426046)
1993
47
Effects of pyridostigmine, corticotropin-releasing hormone and growth hormone-releasing hormone on the pituitary-adrenal axis and on growth hormone secretion in dementia. (8272199)
1993
48
Gliomatosis cerebri presenting with hydrocephalus and dementia. (3124573)
1988
49
Parkinsonism, gait apraxia and dementia associated with intracranial calcifications. A case report. (6845088)
1983
50
Progressive dementia in childhood due to cerebral lipidosis. (5349188)
1969

Genetic Variations for Dementia

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Expression for genes affiliated with Dementia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dementia

Search GEO for disease gene expression data for Dementia.

Pathways for genes affiliated with Dementia

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems
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Compounds for genes affiliated with Dementia

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1serine4412.5SNCA, TRPM7, MAPT, RPS27A, CTSB, PSEN1
2glutamine4412.4SNCA, ATXN2, PSEN1, APOE, APP, RPS27A
3cysteine4412.2PSEN1, ATN1, MAPT, GRN, SNCA, APOE
4glutamate4412.0APOE, ACHE, MAPT, SNCA, APP, CTSB
5valine4411.9APOE, APP, RPS27A, CTSB, SNCA, MAPT
6h2o24411.9RPS27A, MAPT, SNCA, CTSB, PSEN1, APOE
7arginine4411.8CTSB, APOE, APP, RPS27A, PSEN1, SNCA
8alanine4411.8PSEN1, SNCA, RPS27A, APOE, CTSB, MAPT
94-hydroxynonenal44 2412.8APOE, RPS27A, APP, MAPT, SNCA, PSEN1
10lactacystin4411.8SNCA, MAPT, APP, RPS27A, PSEN1, APOE
11carbachol44 28 1113.8ACHE, APP, PSEN1, CTSB, SNCA, MAPT
12nmda44 2812.8PSEN1, APP, APOE, MAPT, ACHE, RPS27A
13acetylcholine44 49 28 11 2415.7ACHE, MAPT, APOE, APP, RPS27A, SNCA
14aspartate4411.7MAPT, CTSB, PSEN1, APOE, RPS27A, APP
15testosterone44 59 11 2414.7ATN1, MAPT, SNCA, APOE, APP, RPS27A
16thioflavine s4411.6SNCA, MAPT, APOE, APP, RPS27A
17formate4411.6MAPT, APOE, SNCA, RPS27A, APP
18chloroquine44 2 49 28 1115.6RPS27A, CTSB, APOE, APP, MAPT
19sodium dodecylsulfate4411.6RPS27A, APOE, SNCA, MAPT, APP
20choline44 11 2413.6MAPT, SNCA, PSEN1, ACHE, APP
21actinomycin d4411.5CTSB, APOE, MAPT, APP, RPS27A
22tacrine44 1112.5ACHE, MAPT, APOE, APP
23paraffin4411.5CTSB, APOE, MAPT, RPS27A, SNCA
24donepezil44 11 2413.5APP, APOE, MAPT, ACHE
25galantamine44 49 1113.5ACHE, APP, APOE, MAPT
26atropine44 28 1113.4ACHE, APP, SNCA, CTSB
27guanidine hydrochloride4411.4SNCA, APOE, RPS27A, CTSB
28kainate44 2812.4MAPT, CTSB, PSEN1, APOE
29biotin44 11 2413.4CTSB, PSEN1, APOE, RPS27A
30threonine4411.3VCP, RPS27A, MAPT, TRPM7, CTSB, PSEN1
31folate4411.3MAPT, APP, APOE, PSEN1
32thioflavin4411.3APP, SNCA, MAPT
33nicotine44 49 28 1114.3APOE, APP, MAPT, ACHE
34metrifonate4411.3APP, APOE, ACHE
35thapsigargin44 5912.3APP, CTSB, PSEN1, VCP
36thioflavin t4411.3SNCA, APOE, APP
37memantine44 28 1113.3ACHE, APP, MAPT
38dopamine44 28 11 2414.3RPS27A, SNCA, APP
39hydrogen44 2412.2SNCA, CTSB, PSEN1, RPS27A
40spec-t4411.2PSEN1, APOE, MAPT
41creatinine4411.2APP, RPS27A, CTSB, MAPT, APOE
42cyclosporin a44 28 5913.1CTSB, APP, RPS27A
43phenserine44 5912.1ACHE, APP
446-hydroxydopamine4411.1RPS27A, APP, SNCA
45rivastigmine44 1112.0APOE, ACHE
46huperzine a4411.0ACHE, APP
47tmao4410.9SNCA, MAPT
48ddvp4410.8APP, ACHE
4924s-hydroxy-cholesterol4410.7APP, APOE
50ginkgo4410.5ACHE, APP

GO Terms for genes affiliated with Dementia

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Sources:
16Gene Ontology
See all sources

Cellular components related to Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00579411.8ACHE, APP, APOE, FAM134B, PSEN1, SNCA
2perinuclear region of cytoplasmGO:04847111.6APP, PSEN1, CTSB, SNCA, ATXN2, ATN1
3axonGO:03042411.3APP, PSEN1, SNCA, MAPT, ACHE
4intracellular membrane-bounded organelleGO:04323111.3APP, CTSB, ITM2B, GRN, VCP
5extracellular spaceGO:00561511.2APOE, CTSB, ITM2B, GRN, ACHE, SERPINI1
6neuromuscular junctionGO:03159410.9ACHE, PSEN1, APP
7growth coneGO:03042610.9MAPT, SNCA, PSEN1
8ciliary rootletGO:03525310.5PSEN1, APP

Biological processes related to Dementia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cell deathGO:00821911.6TRPM7, GRN, CHMP2B, C9orf72, ATXN2, APOE
2neuron apoptotic processGO:05140211.1ATN1, PSEN1, APP
3positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243611.1VCP, NUB1, PSEN1
4smooth endoplasmic reticulum calcium ion homeostasisGO:05156311.0APP, PSEN1
5negative regulation of neuron apoptotic processGO:04352410.9SNCA, PSEN1, APOE
6positive regulation of receptor recyclingGO:00192110.9PSEN1, SNCA
7axon cargo transportGO:00808810.8MAPT, APP
8positive regulation of axon extensionGO:04577310.8MAPT, APOE
9synaptic transmission, cholinergicGO:00727110.7APOE, ACHE
10Notch signaling pathwayGO:00721910.6PSEN1, APP, RPS27A

Molecular functions related to Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.0APP, APOE, PSEN1, CTSB, SNCA, ITM2B
2protein domain specific bindingGO:01990411.1VCP, CHMP2B, ATN1, SNCA
3beta-amyloid bindingGO:00154011.0ACHE, ITM2B, APOE
4tau protein bindingGO:04815610.8SNCA, APOE
5lipoprotein particle bindingGO:07181310.7APOE, MAPT

Products for genes affiliated with Dementia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet