MCID: DMN002
MIFTS: 66

Dementia malady

Mental diseases category
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Summaries for Dementia

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Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Dementia is the name for a group of symptoms caused by disorders that affect the brain. it is not a specific disease. people with dementia may not be able to think well enough to do normal activities, such as getting dressed or eating. they may lose their ability to solve problems or control their emotions. their personalities may change. they may become agitated or see things that are not there. memory loss is a common symptom of dementia. however, memory loss by itself does not mean you have dementia. people with dementia have serious problems with two or more brain functions, such as memory and language. although dementia is common in very elderly people, it is not part of normal aging. many different diseases can cause dementia, including alzheimer's disease and stroke. drugs are available to treat some of these diseases. while these drugs cannot cure dementia or repair brain damage, they may improve symptoms or slow down the disease. nih: national institute of neurological disorders and stroke

MalaCards: Dementia is related to frontotemporal dementia and vascular dementia. An important gene associated with Dementia is MAPT (microtubule-associated protein tau), and among its related pathways are Fanconi anemia pathway and Reelin Pathway (Cajal-Retzius cells). The drugs citalopram and prochlorperazine and the compounds thioflavin and phenserine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are other and taste/olfaction.

Disease Ontology:8 A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.

NINDS:44 Dementia is not a specific disease. It is a descriptive term for a collection of symptoms that can be caused by a number of disorders that affect the brain. People with dementia have significantly impaired intellectual functioning that interferes with normal activities and relationships. They also lose their ability to solve problems and maintain emotional control, and they may experience personality changes and behavioral problems, such as agitation, delusions, and hallucinations. While memory loss is a common symptom of dementia, memory loss by itself does not mean that a person has dementia. Doctors diagnose dementia only if two or more brain functions - such as memory and language skills -- are significantly impaired without loss of consciousness.

Wikipedia:65 Dementia is a broad category of brain diseases that cause long term loss of the ability to think and... more...

Aliases & Classifications for Dementia

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Sources:
8Disease Ontology, 44NINDS, 45Novoseek, 34MedlinePlus, 62UMLS, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

dementia 8 44 45 34 62


External Ids:

Disease Ontology8 DOID:1307
ICD9CM27 290.8
MeSH35 D003704

Related Diseases for Dementia

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 520)
idRelated DiseaseScoreTop Affiliating Genes
1frontotemporal dementia32.0MAPT, PSEN1
2vascular dementia31.9APOE
3semantic dementia31.6RPS27A, MAPT, GRN
4lewy body dementia31.4APOE, SNCA, MAPT
5alzheimer's disease31.4GRN, APOE, APP, VCP, PSEN1, SNCA
6parkinson's disease31.3APOE, SNCA, MAPT, RPS27A
7lateral sclerosis31.2SNCA, MAPT
8pick's disease31.0MAPT, PSEN1
9aphasia31.0TARDBP, GRN, MAPT, C9orf72
10motor neuron disease30.9MAPT, VCP, SNCA, RPS27A, GRN, TARDBP
11amyotrophic lateral sclerosis30.9GRN, MAPT, RPS27A, TARDBP, SNCA, ATXN2
12primary progressive aphasia30.9GRN, MAPT, RPS27A
13binswanger's disease30.8APOE, ACHE, APP
14cerebrovascular disease30.8ACHE, APOE, APP
15cerebral amyloid angiopathy30.8MAPT, PSEN1, APP, APOE, ITM2B
16progressive supranuclear palsy30.8APOE, GRN, MAPT, TARDBP
17rem sleep behavior disorder30.8SNCA
18myopathy30.7VCP, RPS27A, ACHE, APP
19multiple system atrophy30.7RPS27A, MAPT, SNCA
20tauopathy30.7RPS27A, APP, GRN, PSEN1, SNCA, MAPT
21schizophrenia30.6PSEN1, SNCA, ACHE, ATN1
22memory impairment30.6APOE, APP, PSEN1, ACHE, SNCA, MAPT
23down syndrome30.6ACHE, MAPT, SNCA, PSEN1, APP, APOE
24dementia familial british30.5ITM2B, APP
25apraxia30.4GRN, MAPT
26olivopontocerebellar atrophy30.4ATXN2, SNCA
27prion disease30.3MAPT, PSEN1, APP
28huntington's disease30.3RPS27A, ACHE, PSEN1, MAPT, ATN1, APP
29amyloidosis30.2PSEN1, CTSB, APOE, APP, MAPT, RPS27A
30brain disease30.2APP, SNCA, PSEN1, MAPT
31creutzfeldt-jakob disease30.2APP, APOE, SNCA, MAPT, RPS27A
32neuroaxonal dystrophy30.2SNCA, RPS27A
33alzheimer disease type 230.2APOE, MAPT, APP, PSEN1
34frontotemporal lobar degeneration with ubiquitin-positive inclusions30.2GRN
35spinocerebellar ataxia30.0SNCA, ATXN2, MAPT, RPS27A, ATN1
36striatonigral degeneration30.0SNCA, RPS27A
37hereditary cerebral amyloid angiopathy29.8APP
38neuronal intranuclear inclusion disease29.8RPS27A
39dentatorubral-pallidoluysian atrophy29.8ATN1, ATXN2
40spinocerebellar ataxia type 729.8ATXN2
41brain ischemia29.8MAPT, CTSB, APP
42niemann-pick disease29.8APP, SNCA, MAPT
43spinocerebellar ataxia type 1729.7ATN1, ATXN2
44pure autonomic failure29.7ACHE, SNCA
45astrocytoma29.7CTSB, SNCA, APP, PSEN1
46aids dementia complex10.9
47cerebritis10.8
48neuronitis10.8
49cadasil10.6
50hiv-110.5

Graphical network of the top 20 diseases related to Dementia:



Diseases related to dementia

Symptoms for Dementia

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Drugs & Therapeutics for Dementia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Dementia

Search NIH Clinical Center for Dementia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Dementia

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Anatomical Context for Dementia

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Sources:
33MalaCards
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MalaCards organs/tissues related to Dementia:

33
Brain, Cortex, Testes, Bone, Temporal lobe, Heart, Monocytes, T cells, Endothelial, Skin, Eye, Amygdala, Prefrontal cortex, Spinal cord, Thalamus, Caudate nucleus, B cells, Hypothalamus, Cerebellum, Liver, Thyroid, Spleen, Kidney, Parietal lobe

Animal Models for Dementia or affiliated genes

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Sources:
37MGI
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Publications for Dementia

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Sources:
52PubMed
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Articles related to Dementia:

(show top 50)    (show all 4197)
idTitleAuthorsYear
1
An Exploratory Study of Grief and Health-Related Quality of Life for Caregivers of People With Dementia. (24381138)
2013
2
Posttraumatic stress disorder exacerbation with cholinesterase inhibitor in a patient with dementia. (24307975)
2013
3
Immunological Aspects and Anti-Amyloid Strategy for Alzheimer's Dementia / IMUNOLOA KI ASPEKTI I ANTIAMILOIDNE STRATEGIJE ZA ALZHEIMEROVU DEMENCIJU. (24384767)
2013
4
Attachment and coping of dementia care staff: The role of staff attachment style, geriatric nursing self-efficacy, and approaches to dementia in burnout. (24339071)
2013
5
Dementia Care in Nursing Barker Sue Board Michele Dementia Care in Nursing 184pp AL18.99 Sage 9780857258014 085725801X [Formula: see text]. (24283316)
2013
6
Evaluation of an education intervention to implement a capability model of dementia care. (24339075)
2013
7
The contribution of twins to the study of cognitive ageing and dementia: The Older Australian Twins Study. (24423226)
2013
8
The effectiveness of dyadic interventions for people with dementia and their caregivers. (24337642)
2013
9
Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia. (22335970)
2012
10
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies. (22226802)
2012
11
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. (22406228)
2012
12
I+-Synuclein mRNA and soluble I+-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease. (22560502)
2012
13
Phenotypic signatures of genetic frontotemporal dementia. (21986680)
2011
14
Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin. (21185921)
2011
15
Reverse concreteness effects are not a typical feature of semantic dementia: evidence for the hub-and-spoke model of conceptual representation. (21285258)
2011
16
Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)
2011
17
Clinical profiles of late-onset semantic dementia, compared with early-onset semantic dementia and late-onset Alzheimer's disease. (21447109)
2011
18
Clinical staging and disease progression in frontotemporal dementia. (20479357)
2010
19
Frontotemporal dementia phenotype associated with MAPT gene duplication. (20634582)
2010
20
Interleukin-1 beta (C-511T) genetic polymorphism is associated with cognitive performance in elderly males without dementia. (19013689)
2010
21
Inclusion body myopathy and frontotemporal dementia caused by a novel VCP mutation. (17889967)
2009
22
Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. (19073835)
2009
23
No association of common VCP variants with sporadic frontotemporal dementia. (17618707)
2009
24
Minimally invasive surgical approach for three-vessel occlusion as a model of vascular dementia in the rat-brain bioenergetics assay. (19272617)
2009
25
Expert opinion on the management of behavioural and psychological symptoms of dementia (BPSD) and investigation into prescribing practices in the UK. (19156700)
2009
26
Small vessel versus large vessel vascular dementia: risk factors and MRI findings. (18677637)
2008
27
Communication impairment in the AIDS dementia complex (ADC): a case report. (18242630)
2008
28
Defining "prodromal" Alzheimer's disease, frontotemporal dementia, and Lewy body dementia: are we there yet? (18327642)
2008
29
Nitrosative stress with HIV dementia causes decreased L-prostaglandin D synthase activity. (18077799)
2008
30
Statins and dementia. (17877925)
2007
31
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
32
Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer's type in an elderly Arab population in Wadi Ara, Israel. (18568123)
2005
33
Jargon dyslexia in an individual with semantic dementia: further evidence for task-specificity in phonological output. (16251136)
2005
34
Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease: a comparison. (15136683)
2004
35
A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. (14746899)
2004
36
The contribution of autobiographical significance to semantic memory: evidence from Alzheimer's disease, semantic dementia, and amnesia. (14615074)
2004
37
The role of viruses and of APOE in dementia. (15246985)
2004
38
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. (12364720)
2002
39
Hyperphosphorylated tau deposition parallels prion protein burden in a case of Gerstmann-StrAoussler-Scheinker syndrome P102L mutation complicated with dementia. (12200619)
2002
40
Hypersensitive mousetraps, alpha1-antitrypsin deficiency and dementia. (12023831)
2002
41
Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia--an epidemiological study using the polymerase chain reaction (PCR) method. (10860300)
2000
42
Search for a mutation in the tau gene in a Swiss family with frontotemporal dementia. (10683298)
2000
43
A stop-codon mutation in the BRI gene associated with familial British dementia. (10391242)
1999
44
Motor neuron disease-inclusion dementia presenting as cortical-basal ganglionic degeneration. (10435507)
1999
45
Vasodilator responses to acetazolamide tested in subtypes of vascular dementia. (17895108)
1998
46
Dementia pugilistica and cavum septi pellucidi: born to box? (9421861)
1997
47
Diagnosing Alzheimer's disease in very elderly patients. Relevance of some functional and psychobehavioral aspects assessed by the Gottfries-BrAYne-Steen Rating Scale for Dementia. Study Group on Brain Aging, Italian Society of Gerontology and Geriatrics. (9386985)
1997
48
Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins. (7717459)
1995
49
Review of antiretroviral therapy in the prevention of HIV-related AIDS dementia complex (ADC). (7614899)
1995
50
Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex: an immunohistochemical study. (2161095)
1990

Variations for Dementia

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Expression for genes affiliated with Dementia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dementia

Search GEO for disease gene expression data for Dementia.

Pathways for genes affiliated with Dementia

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Sources:
50PathCards, 30KEGG, 55Reactome, 53QIAGEN, 54R&D Systems, 38NCBI BioSystems Database, 5Cell Signaling Technology
See all sources

Pathways related to Dementia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0RPS27A, VCP
29.9MAPT, APP, APOE
39.8CTSB, PSEN1, APP
49.6APOE, APP, PSEN1, MAPT
5
Show member pathways
Alzheimers Disease38
9.0MAPT, SNCA, MT-ATP6, PSEN1, APP, APOE
68.9APOE, APP, CHMP2B, ITM2B, SNCA, RPS27A
78.8APOE, APP, PSEN1, SNCA, MAPT, TARDBP

Compounds for genes affiliated with Dementia

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 11DrugBank, 24HMDB, 3BitterDB
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Compounds related to Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1thioflavin4510.2SNCA, MAPT, APP
2phenserine45 6111.2APP, ACHE
3memantine45 29 51 1113.1MAPT, ACHE, APP
4thioflavin t4510.1SNCA, APP, APOE
5metrifonate4510.0APP, ACHE, APOE
6spec-t4510.0PSEN1, APOE, MAPT
7huperzine a4510.0ACHE, APP
8ddvp459.9APP, ACHE
9tacrine45 1110.9ACHE, APOE, APP, MAPT
10donepezil45 51 24 1112.9ACHE, APOE, APP, MAPT
11galantamine45 51 1111.9APOE, MAPT, ACHE, APP
126-hydroxydopamine459.9APP, RPS27A, SNCA
13kainate45 2910.8CTSB, MAPT, PSEN1, APOE
14folate459.8APOE, MAPT, PSEN1, APP
15rivastigmine45 1110.8APOE, ACHE
16chloroquine45 3 51 29 1113.8CTSB, RPS27A, APP, APOE, MAPT
17atropine45 29 1111.7APP, SNCA, ACHE, CTSB
18guanidine hydrochloride459.7CTSB, RPS27A, SNCA, APOE
19thioflavine s459.7MAPT, APOE, APP, SNCA, RPS27A
20biotin45 24 1111.7APOE, PSEN1, RPS27A, CTSB
21formate459.7MAPT, RPS27A, SNCA, APOE, APP
22thapsigargin45 6110.7PSEN1, APP, VCP, CTSB
23nicotine45 29 51 1112.7APOE, APP, ACHE, MAPT
24tmao459.7SNCA, MAPT
25sodium dodecylsulfate459.7MAPT, APOE, SNCA, RPS27A, APP
26actinomycin d459.7APP, APOE, RPS27A, MAPT, CTSB
27cyclosporin a45 29 6111.6APP, RPS27A, MAPT, CTSB, APOE
28choline45 24 1111.5ACHE, SNCA, PSEN1, MAPT, APP
29creatinine459.5CTSB, RPS27A, APOE, MAPT, APP
30paraffin459.5CTSB, MAPT, RPS27A, SNCA, APOE
314-hydroxynonenal45 2410.4MAPT, RPS27A, APP, APOE, PSEN1, SNCA
32lactacystin459.4MAPT, RPS27A, SNCA, PSEN1, APP, APOE
33heparin45 29 24 1112.4SNCA, MAPT, APOE, APP, CTSB
34aspartate459.4APOE, APP, PSEN1, RPS27A, MAPT, CTSB
35hydrogen45 2410.4MT-ATP6, PSEN1, SNCA, CTSB, RPS27A
36testosterone45 61 24 1112.4MAPT, APP, RPS27A, SNCA, APOE, ATN1
37carbachol45 29 1111.3APP, PSEN1, ACHE, SNCA, MAPT, CTSB
38threonine459.3CTSB, MAPT, RPS27A, PSEN1, VCP, TRPM7
39acetylcholine45 51 29 24 1113.3APOE, MAPT, RPS27A, SNCA, ACHE, APP
40dopamine45 29 24 1112.3MAPT, ACHE, APP, APOE, RPS27A, SNCA
41valine459.2SNCA, CTSB, MAPT, PSEN1, RPS27A, APP
42h2o2459.1SNCA, PSEN1, APP, APOE, RPS27A, MAPT
43cycloheximide459.1RPS27A, MAPT, CTSB, APOE, PSEN1
44nmda45 2910.1PSEN1, APOE, CTSB, MAPT, RPS27A, ACHE
45arginine459.1RPS27A, SNCA, PSEN1, APP, CTSB, APOE
46alanine459.1SNCA, RPS27A, APOE, CTSB, APP, MAPT
47glutamate458.8ACHE, SNCA, PSEN1, APP, APOE, MAPT
48cysteine458.6GRN, MAPT, CTSB, RPS27A, SNCA, PSEN1
49glutamine458.5VCP, MAPT, CTSB, RPS27A, SNCA, PSEN1
50serine458.3CTSB, TRPM7, APOE, MAPT, SNCA, ACHE

GO Terms for genes affiliated with Dementia

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Sources:
16Gene Ontology
See all sources

Cellular components related to Dementia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1ciliary rootletGO:03525310.0PSEN1, APP
2nuclear outer membraneGO:0056409.9SNCA, PSEN1
3neuromuscular junctionGO:0315949.8APP, PSEN1, ACHE
4growth coneGO:0304269.6PSEN1, SNCA, MAPT
5intracellular membrane-bounded organelleGO:0432319.5CTSB, GRN, ITM2B, VCP, APP
6axonGO:0304249.3APP, PSEN1, ACHE, SNCA, MAPT
7extracellular spaceGO:0056159.0APOE, C9orf72, ACHE, ITM2B, GRN, CTSB
8extracellular vesicular exosomeGO:0700628.8APOE, APP, VCP, CHMP2B, ITM2B, RPS27A
9Golgi apparatusGO:0057948.7ATXN2, APOE, APP, FAM134B, PSEN1, ACHE
10extracellular regionGO:0055768.6APOE, APP, ACHE, ITM2B, SNCA, CTSB
11perinuclear region of cytoplasmGO:0484718.6CTSB, ATXN2, ATN1, APP, VCP, PSEN1

Biological processes related to Dementia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1axon cargo transportGO:00808810.4MAPT, APP
2smooth endoplasmic reticulum calcium ion homeostasisGO:05156310.3PSEN1, APP
3positive regulation of axon extensionGO:04577310.1APOE, MAPT
4positive regulation of receptor recyclingGO:00192110.1SNCA, PSEN1
5neuron apoptotic processGO:05140210.0ATN1, APP, PSEN1
6regulation of protein bindingGO:04339310.0APP, PSEN1
7positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:0324369.9PSEN1, VCP, NUB1
8response to interferon-gammaGO:0343419.9SNCA, NUB1
9synaptic transmission, cholinergicGO:0072719.9ACHE, APOE
10Notch signaling pathwayGO:0072199.9RPS27A, PSEN1, APP
11negative regulation of neuron apoptotic processGO:0435249.7APOE, PSEN1, SNCA
12regulation of apoptotic processGO:0429819.6CTSB, RPS27A, VCP
13Notch receptor processingGO:0072209.6RPS27A, PSEN1
14cell deathGO:0082198.9TARDBP, GRN, CHMP2B, C9orf72, APOE, ATXN2

Molecular functions related to Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tau protein bindingGO:0481569.9SNCA, APOE
2lipoprotein particle bindingGO:0718139.7MAPT, APOE
3beta-amyloid bindingGO:0015409.7APOE, ACHE, ITM2B
4protein domain specific bindingGO:0199049.3SNCA, CHMP2B, VCP, ATN1
5identical protein bindingGO:0428028.9APOE, APP, VCP, SNCA, TARDBP
6protein bindingGO:0055156.7CTSB, ATXN2, ATN1, NUB1, APOE, APP

Products for genes affiliated with Dementia

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  • Antibodies
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  • Antibodies

Sources for Dementia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet