Dementia malady

MedlinePlus: Dementia is a word for a group of symptoms caused by disorders that affect the brain. it is not a specific disease. people with dementia may not be able to think well enough to do normal activities, such as getting dressed or eating. they may lose their ability to solve problems or control their emotions. their personalities may change. they may become agitated or see things that are not there. memory loss is a common symptom of dementia. however, memory loss by itself does not mean you have dementia. people with dementia have serious problems with two or more brain functions, such as memory and language. many different diseases can cause dementia, including alzheimer's disease and stroke. drugs are available to treat some of these diseases. while these drugs cannot cure dementia or repair brain damage, they may improve symptoms or slow down the disease. nih: national institute of neurological disorders and stroke²³

MalaCards: Dementia is related to neuronitis and cerebritis. An important gene associated with Dementia is ITM2B (integral membrane protein 2B), and among its related pathways are Neuroscience and Metabolic pathways. The drugs citalopram hydrobromide and citalopram and the compounds calcium and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are nervous system and cardiovascular system.

Disease Ontology: A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.⁶

NINDS: Dementia is not a specific disease. It is a descriptive term for a collection of symptoms that can be caused by a number of disorders that affect the brain. People with dementia have significantly impaired intellectual functioning that interferes with normal activities and relationships. They also lose their ability to solve problems and maintain emotional control, and they may experience personality changes and behavioral problems, such as agitation, delusions, and hallucinations. While memory loss is a common symptom of dementia, memory loss by itself does not mean that a person has dementia. Doctors diagnose dementia only if two or more brain functions - such as memory and language skills -- are significantly impaired without loss of consciousness.³¹

Wikipedia: Dementia (taken from Latin) originally meaning madness, from de- (without) + ment, the root of mens...⁴⁴ more...

Aliases & Descriptions:

dementia 6 7 17 31 32 23 43

Diseases related to dementia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1045)

id	Related Disease	Score	Top Affiliating Genes
1	neuronitis	71.3	PINK1, PIK3C2A, PIK3CG, PIN1, LRP1, LRP8
2	cerebritis	56.9	PIK3C2A, PIK3CG, LRP1, LRP8, NCAM1, PDE4A
3	frontotemporal dementia	55.5	PIN1, RELN, CNBP, PCSK1N, PCBP3, SEMA3A
4	cholesterol	53.8	PIK3C2A, PIK3CG, LRP1, LRP8, LRPAP1, NCOA6
5	neurodegenerative disease	51.7	PINK1, PIK3CG, PIN1, LRP1, NCAM1, RELN
6	neurodegeneration	51.4	PINK1, PIK3CG, PIN1, LRP1, RELN, SERPINI1
7	parkinson's disease	51.4	PINK1, SERPINF1, SERPINA3, NAT2, VCP, BLVRB
8	lateral sclerosis	49.8	PCSK1N, SERPINE1, VEGFA, LPA, LPL, VCP
9	amyotrophic lateral sclerosis	49.5	PCSK1N, SERPINE1, VEGFA, LPA, LPL, VCP
10	neuroblastoma	46.1	PIK3CG, PIN1, LRP1, NCAM1, PDE4A, RELN
11	diabetes mellitus	45.2	PIK3C2A, PIK3CG, PDE4A, VWF, GCKR, SELP
12	hypertension	44.6	PIK3C2A, PIK3CG, LRP1, LRP8, NCAM1, PDE4A
13	cadasil	44.5	VWF, SELP, SERPINC1, SERPINI1, SERPINE1, SERPINA3
14	down syndrome	44.3	NCAM1, SERPINC1, SERPINE1, SERPINA3, VIP, VEGFA
15	ischemia	43.7	PIK3C2A, PIK3CG, NCAM1, PDE4A, VWF, PCNA
16	retinitis	43.5	PIK3C2A, PIK3CG, LRP1, LRPAP1, PDE4A, CNBP
17	neuropathy	43.1	PIK3C2A, NCAM1, PDE4A, VWF, SERPINF1, SERPINE1
18	atherosclerosis	42.6	PIK3C2A, PIK3CG, LRP1, LRP8, LRPAP1, PDE4A
19	ataxia	42.6	PIK3CG, PIN1, LRP1, VWF, PCBP2, PCNA
20	vascular dementia	42.4	SERPINA3, VEGFA, LPA, BCHE, CHAT, MTHFR
21	obesity	42.0	PIK3C2A, PIK3CG, LRP1, VWF, SFTPD, PCSK9
22	myopathy	41.4	PIK3C2A, NCAM1, CNBP, VCAM1, VCP, CLU
23	multiple system atrophy	40.5	SERPINA3, PARK7, PARK2, BDNF, CHAT, UCHL1
24	myocardial infarction	40.1	PIK3C2A, PIK3CG, LRP1, LRP8, LRPAP1, PDE4A
25	alzheimer's disease	40.0	CLU, ITM2B, APOE, APP, MAPT, IDE
26	aids dementia complex	39.8	NCOA6, BDNF, S100B, B2M, CD27, CD4
27	lewy body dementia	39.0	PARK7, PARK2, BCHE, CDK5, APOE, APP
28	pick's disease	38.9	PCSK1N, CLU, PARK7, BDNF, SCG2, CHIT1
29	homocysteine	38.9	PIK3C2A, VWF, PCNA, SELP, SERPINC1, SERPINE1
30	brain injury	38.7	NCAM1, VWF, SELP, SERPINC1, SERPINI1, SERPINE1
31	supranuclear palsy	38.4	VEGFA, PARK7, PARK2, BCHE, CHRM2, CHAT
32	motor neuron disease	38.2	NAT2, VEGFA, VCP, BDNF, CHAT, CHMP2B
33	seizures	37.8	PIK3C2A, SERPINI1, VLDLR, VIP, VEGFA, CLN5
34	cerebrovascular disease	37.6	VWF, SELP, SERPINC1, SERPINE1, SERPINA3, VIP
35	immunodeficiency	36.8	VIP, PARK2, BCR, CHRM2, SAG, CD4
36	blindness	36.7	PIK3C2A, PIK3CG, PDE4A, CNBP, VWF, SELP
37	type 2 diabetes mellitus	36.7	VWF, GCKR, SELP, SERPINE1, NAT2, LPA
38	amyloidosis	36.5	LRP1, VWF, PCBP2, SERPINC1, SERPINA3, LPA
39	pneumonia	36.4	PIK3C2A, PDE4A, SFTPD, SERPINC1, SERPINA1, SERPINE1
40	tauopathy	36.2	SERPINI1, PARK7, PARK2, CDK5, CDKN3, INA
41	encephalitis	36.0	PIK3CG, VEGFA, VCAM1, CLDN5, BDNF, BCL2
42	spasticity	36.0	VEGFA, PANK2, BCR, MTHFR, MT-ATP6, MT-ND1
43	traumatic brain injury	35.6	SERPINC1, SERPINI1, VEGFA, BDNF, BCL2, CHRM1
44	cerebral amyloid angiopathy	35.4	LRP1, SERPINA3, BCHE, ITM2B, MME, MMP9
45	gliosis	35.3	PARK2, CHAT, BACE1, S100B, ATXN1, ITIH4
46	alcoholism	35.2	CHRM2, LBR, ARSA, GSR, IL1RN, MAPT
47	inclusion body myopathy	35.1	NCAM1, VCP, MPFD, MME, APP, GNE
48	paget's disease of bone	34.9	VCP, UBA52, B2M, IL1B, IL6, IL8
49	huntington's disease	34.8	SERPINI1, SERPINA3, NAT2, BLVRB, BDNF, SDHB
50	progressive supranuclear palsy	34.8	PARK7, PARK2, CHAT, CDK5, APOE, APP

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 citalopram, citalopram hydrobromide, prochlorperazine, prochlorperazine edisylate, prochlorperazine maleate, risperidone

MalaCards organs/tissues related to dementia:

²²

MGI Mouse Phenotypes related to dementia:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system phenotype	MP:0003631	22.2	LRP1, LRP8, LRPAP1, NCOA6, PDE4A, RELN
2	cardiovascular system phenotype	MP:0005385	16.5	PIK3CG, LRP1, NCOA6, PDE4A, VWF, PCSK6
3	normal phenotype	MP:0002873	16.2	LRP1, LRP8, LRPAP1, KIAA1217, VIP, VEGFA
4	muscle phenotype	MP:0005369	14.5	PIK3CG, LRP1, NCOA6, RELN, VEGFA, LPL
5	vision/eye phenotype	MP:0005391	14.4	PIN1, NCAM1, NCOA6, RELN, CNBP, PCSK6
6	renal/urinary system phenotype	MP:0005367	13.9	LRPAP1, KIAA1217, SELP, CLU, BCL2, BCR
7	respiratory system phenotype	MP:0005388	13.9	SFTPD, PCSK6, SELP, SEMA3A, SERPINB1, LPL
8	no phenotypic analysis	MP:0003012	13.8	PINK1, PCNA, SEMA3A, VEGFA, VCAM1, LIPG
9	digestive/alimentary phenotype	MP:0005381	13.7	NCOA6, RELN, KIAA1217, VWF, PCSK6, SERPINF1
10	liver/biliary system phenotype	MP:0005370	13.2	NCOA6, PCSK9, SERPINC1, VEGFA, LPL, CLN3
11	craniofacial phenotype	MP:0005382	13.1	NCOA6, CNBP, PCSK6, BDNF, CISD2, CHRNB2
12	adipose tissue phenotype	MP:0005375	11.7	PIK3C2A, LRP1, SERPINE1, VLDLR, LPL, BCL2
13	tumorigenesis	MP:0002006	11.6	SERPINE1, BCL2, B2M, CDKN1B, CDK1, ITGAL
14	other phenotype	MP:0005395	11.6	LRPAP1, CLU, LDLR, BACE1, MME, FBN1
15	embryogenesis phenotype	MP:0005380	11.4	NCOA6, CNBP, KIAA1217, PCSK6, SERPINC1, SCARB1
16	reproductive system phenotype	MP:0005389	INF	LRP8, LRPAP1, NCOA6, KIAA1217, SERPINF1, VIP
17	behavior/neurological phenotype	MP:0005386	INF	PINK1, LRP1, LRP8, NCAM1, RELN, PCSK1N
18	endocrine/exocrine gland phenotype	MP:0005379	INF	PINK1, LRPAP1, PANK2, CISD2, LDLR, ATXN2
19	integument phenotype	MP:0010771	INF	PIK3CG, PIN1, NCOA6, RELN, SELP, BLMH
20	hematopoietic system phenotype	MP:0005397	INF	PCNA, SERPINB1, BCL2, CHRNB2, UCHL1, MTA2
21	mortality/aging	MP:0010768	INF	PIK3C2A, LRP1, LRP8, LRPAP1, NCAM1, NCOA6
22	cellular phenotype	MP:0005384	INF	PINK1, PIK3CG, PIN1, LRP8, NCAM1, NCOA6
23	homeostasis/metabolism phenotype	MP:0005376	INF	PINK1, PIK3C2A, PIK3CG, LRP1, LRPAP1, NCOA6
24	skeleton phenotype	MP:0005390	INF	PIK3CG, LRP1, CNBP, KIAA1217, SEMA3A, VEGFA
25	hearing/vestibular/ear phenotype	MP:0005377	INF	BDNF, BCL2, BCR, SCARB2, CISD2, CHRM1
26	immune system phenotype	MP:0005387	INF	PINK1, LRP1, PDE4A, VWF, SELP, SEMA3A
27	growth/size phenotype	MP:0005378	INF	PINK1, PIK3C2A, PIK3CG, PIN1, LRP1, LRP8

Articles related to dementia:

(show top 50)    (show all 1531)

id	Title	Authors	Year	Affiliating Genes
1	Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)	Ning M.... He L.	2011	MAPT
2	Cerebrospinal fluid tau, p-tau 181 and amyloid-I^38/40 /42 in frontotemporal dementias and primary progressive aphasias. (21135556)	Bibl M.... Wiltfang J.	2011	APP, MAPT
3	Dementia: progress in diagnosis and treatment: topic s, V. Recent topics; 4. Detection of novel dementia-related genes; 1) TDP-43]. (21899152)	Akiyama H.	2011	TARDBP
4	Dementia: progress in diagnosis and treatment; Topic s, V. Recent topics; 4. Detection of novel dementia-related genes; 2) Dysregula tion of TGF-beta family signaling and hereditary cerebral small vessel disease: insight into molecular pathogenesis of CARASIL]. (21899153)	Nozaki H.... Onodera O.	2011	HTRA1
5	Association between apolipoprotein E4 genotype and hu man immunodeficiency virus-associated dementia in younger adults starting antir etroviral therapy in South Africa. (20825268)	Joska J.A.... Stein D.J.	2010	APOE
6	Quantification of myelin loss in frontal lobe white m atter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies. (20091409)	Ihara M.... Kalaria R.N.	2010	MBP
7	Serotonin transporter triallelic genotype and respons e to citalopram and risperidone in dementia with behavioral symptoms. (19996755)	Dombrovski A.Y.... Pollock B.G.	2010	SLC6A4
8	Frontotemporal dementia in association with a family history of dementia and ApoE polymorphism (19629426)	Zintl M.... KlA1nemann H.H.	2010	APOE
9	The genetics of dementias. Part 1: Molecular basis o f frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) (19535823)	Kowalska A.	2009	MAPT
10	Dopamine D3 Receptor Gene Polymorphism Influences on Behavioral and Psychological Symptoms of Dementia (BPSD) in Mild Dementia of Alzheimer's Type. (19363270)	Sato N.... Morita Y.	2009	APOE, DRD3
11	The role of the -427T/C apolipoprotein E promoter polymorphism in the pathogenesis of Alzheimer's disease, vascular dementia and mixed dementia. (19142571)	TrebunovA! M.... GdovinovA! Z.	2009	APOE
12	Lewy body dementia and Parkinson's disease with dementia. (18787881)	Dodel R.... Schulz J.B.	2008	SNCA
13	Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Parkinson's disease dementia. (18841018)	Sharp S.I.... Francis P.T.	2008	HTR1A
14	Neuropsychological characteristics of dementia with Lewy bodies and Parkinson's disease with dementia: differentiation, early detection, and implications for 'mild cognitive impairment' and biomarkers. (18322801)	TrAPster A.I.	2008	SNCA
15	The ACE Insertion Deletion polymorphism relates to dementia by metabolic phenotype, APOEvarepsilon4, and age of dementia onset. (18838196)	Gustafson D.R.... Skoog I.	2008	ACE, APOE
16	Accounting for the relationship between low education and dementia: a twin study. (17597169)	Gatz M.... Pedersen N.L.	2007	APOE
17	Lewy body dementia and Parkinson disease dementia (17572053)	Meyniel C.... Damier P.	2007	ACHE
18	Dementia with Lewy bodies and Parkinson's disease with dementia: where two worlds collide. (18024777)	McKeith I.	2007	SNCA
19	Psychotropic medication use for behavioral symptoms o f dementia. (17074284)	Wang P.S.... Schneeweiss S.	2006	ACHE
20	Semantic dementia, a many-worded disorder (17133330)	O'Neill S.... De Simone V.	2006	RPS27A
21	Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia. (16783499)	Yasutake C.... Yoneda H.	2006	IL1B, BDNF
22	CHMP2B mutations are not a cause of dementia in Dutch patients with familial and sporadic frontotemporal dementia. (16941655)	Rizzu P.... van Swieten J.C.	2006	CHMP2B
23	Cerebral arachidonate cascade in dementia: Alzheimer's disease and vascular dementia. (18615138)	Yagami T.	2006	PLA2G2A, COX5A
24	Assessment of dementia and use of anti-dementia drugs in nursing homes (15880157)	Engedal K.	2005	ACHE
25	Noninfarct vascular dementia and Alzheimer dementia s pectrum. (15760616)	Emery V.O.... Smith J.A.	2005	VEGFA
26	Links between the pathology of Alzheimer's disease an d vascular dementia. (15176482)	Sadowski M.... Wisniewski T.	2004	APP
27	(r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia. (14991456)	Frolich L.... Riederer P.	2004	SDHB
28	Are the Danish Society of General Practitioners' cli nical guidelines concerning 'Identification and investigation of dementia and dementia-like conditions' useful as the basis of dementia investigatio n in general practice? (12812104)	Errebo-Knudsen L.... Kristensen K.A.	2003	ACHE
29	Senile dementia of the neurofibrillary tangle type (tangle-only dementia): neuropathological criteria and clinical guidelines for diagnosis. (14719548)	Yamada M.	2003	APP
30	An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementia. (12860497)	Erkinjuntti T.... Damaraju C.V.	2003	ACHE
31	Role of CRH in the pathogenesis of dementia of Alzheimer's type and other dementias. (12476966)	Rehman H.U.	2002	CRH
32	Correlation of rCBF (SPECT), CSF tau, and cognitive function in patients with dementia of the Alzheimer's type, other types of dementia, and control subjects. (11416945)	Tsolaki M.... Kazis A.	2001	MAPT
33	The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and vascular dementia. (10855603)	Pollak R.D.... Blumenfeld A.	2000	MTHFR
34	CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging. (11072752)	SjAPgren M.... Blennow K.	2000	GAP43
35	Effect pf anti-dementia drugs on the daily routine a nd attitude of dementia patients (10436496)	Kurz A.	1999	ACHE
36	Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia. (9598683)	Hansen L.A.... Love S.	1998	SYP
37	Coagulation and fibrinolysis markers and risk of dementia. The Dutch Vascular Factors in Dementia Study. (10420069)	Bots M.L.... Kluft C.	1998	F2
38	Neuropathologic markers in degenerative dementias (9834544)	Hauw J.J.... Duyckaerts C.	1998	MAPT, PRNP
39	Response to activated protein C in subjects with and without dementia. The Dutch Vascular Factors in Dementia Study. (10420068)	Bots M.L.... Kluft C.	1998	F5
40	Dementia of frontal type and dementias with subcortic al gliosis. (9546290)	Mann D.M.	1998	RPS27A
41	Rapidly progressive autosomal dominant Parkinsonism and dementia with Pallido-Ponto-Nigral Gegeneration (PPND) and Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex (DDPAC) are clinically distinct conditions that are both linked to 17q21-22. (18591058)	Wszolek Z.K.... Wilhelmsen K.C.	1997	MAPT
42	Comparative study of ubiquitin immunoreactivity of hi ppocampal granular cells in amyotrophic lateral sclerosis with dementia, Guaman ian amyotrophic lateral sclerosis and Guamanian parkinsonism-dementia complex. (9083558)	Ikemoto A.... Kimura J.	1997	RPS27A
43	Effects of apolipoprotein E on dementia and aging in the Shanghai Survey of Dementia. (9305340)	Katzman R.... Yu E.S.	1997	APOE
44	Presenilin-1 polymorphism in patients with Alzheimer's disease, vascular dementia and alcohol-associated dementia in Japanese population. (8947284)	Isoe K.... Nakashima K.	1996	PSEN1
45	Apolipoprotein E in patients with dementia of the Alzheimer type and vascular dementia. (8741132)	Isoe K.... Takahashi K.	1996	APOE
46	Apolipoprotein E (APOE) allele frequencies in late-onset sporadic Alzheimer's disease (AD), mixed dementia and vascular dementia: lack of association of epsilon 4 allele with AD in Italian octogenarian patients. (8786847)	Scacchi R.... Corbo R.M.	1995	APOE
47	Synaptophysin immunoreactivity of the cortical neuropil in vascular dementia of Binswanger type compared with the dementia of Alzheimer type and nondemented controls. (8038870)	Zhan S.S.... Schmitt H.P.	1994	SYP
48	Apo E allele frequencies in Alzheimer's disease, Lewy body dementia, Alzheimer's disease with cerebrovascular disease and vascular dementia. (7841371)	BActard C.... Gauvreau D.	1994	APOE
49	Vascular dementia in Spatz-Lindenberg's disease (SLD): cortical synaptophysin immunoreactivity as compared with dementia of Alzheimer type and non-demented controls. (8213084)	Zhan S.S.... Schmitt H.P.	1993	SYP
50	Plasma and serum G4 isoenzyme of acetylcholinesterase in patients with Alzheimer-type dementia and vascular dementia. (2403232)	Yamamoto Y.... Kameyama M.	1990	ACHE

Genes related to dementia according to GeneCards:

(show top 50)    (show all 578)

id	Symbol	Description	Score	GeneCards Section Context
1	ITM2B	integral membrane protein 2B	11.1	Summaries, Publications
2	MAPT	microtubule-associated protein tau	11.1	Publications, Summaries
3	APP	amyloid beta (A4) precursor protein	11.1	Publications, Summaries
4	TRPM7	transient receptor potential cation channel, subfamily M, member 7	11.0	Publications, Summaries
5	C9orf72	chromosome 9 open reading frame 72	11.0	Publications, Summaries
6	FAM134B	family with sequence similarity 134, member B	11.0	Publications, Summaries
7	MT-ATP6	mitochondrially encoded ATP synthase 6	11.0	Aliases & Descriptions
8	ATN1	atrophin 1	11.0	Summaries
9	ATXN2	ataxin 2	11.0	Publications, Summaries
10	CTSB	cathepsin B	11.0	Summaries
11	APOE	apolipoprotein E	11.0	Publications
12	RPS27A	ribosomal protein S27a	11.0	Publications
13	ACHE	acetylcholinesterase	11.0	Publications
14	GRN	granulin	11.0	Publications, Orthologs
15	PSEN1	presenilin 1	11.0	Publications
16	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
17	SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1	11.0	Publications
18	NUB1	negative regulator of ubiquitin-like proteins 1	11.0	Summaries
19	CHMP2B	charged multivesicular body protein 2B	11.0	Publications
20	VCP	valosin containing protein	11.0	Publications
21	TARDBP	TAR DNA binding protein	11.0	Publications
22	BCHE	butyrylcholinesterase	11.0	Publications
23	BDNF	brain-derived neurotrophic factor	11.0	Publications
24	SOD1	superoxide dismutase 1, soluble	11.0	Publications
25	TNF	tumor necrosis factor	11.0	Publications
26	SNCB	synuclein, beta	11.0	Publications
27	CHAT	choline O-acetyltransferase	11.0	Publications
28	NOTCH3	notch 3	11.0	Publications
29	PRNP	prion protein	11.0	Publications
30	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
31	LRRK2	leucine-rich repeat kinase 2	11.0	Publications
32	MBP	myelin basic protein	11.0	Publications
33	PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	11.0	Publications
34	STH	saitohin	11.0	Publications
35	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
36	PSEN2	presenilin 2 (Alzheimer disease 4)	11.0	Publications
37	CCR3	chemokine (C-C motif) receptor 3	11.0	Publications
38	CRH	corticotropin releasing hormone	11.0	Publications
39	CRYAB	crystallin, alpha B	11.0	Publications
40	CST3	cystatin C	11.0	Publications
41	GFAP	glial fibrillary acidic protein	11.0	Publications
42	ITIH4	inter-alpha-trypsin inhibitor heavy chain family, member 4	11.0	Publications
43	TAT	tyrosine aminotransferase	11.0	Publications
44	ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	11.0
45	BACE1	beta-site APP-cleaving enzyme 1	11.0	Publications
46	FUS	fused in sarcoma	11.0	Publications
47	GAP43	growth associated protein 43	11.0	Publications
48	SQSTM1	sequestosome 1	11.0	Publications
49	CXCR4	chemokine (C-X-C motif) receptor 4	11.0	Publications
50	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	11.0	Publications

Pathways related to dementia according to GeneDecks:

(show top 50)    (show all 103)

id	Pathway	Score	Top Affiliating Genes
1	Neuroscience3	15.1	PINK1, NCAM1, PARK7, BACE1, SAG, S100B
2	Metabolic pathways20	14.5	PIK3C2A, NAT2, LIPG, LIPC, PANK2, SDHB
3	Alzheimers disease20	12.8	LRP1, LPL, SDHB, BACE1, MT-ATP6, CDK5
4	Akt Signaling36	11.8	PIK3CG, SEMA3A, CD4, ITGAL, GSK3B, IL10
5	Rheumatoid arthritis20	11.7	VEGFA, JUN, ITGAL, MMP1, MMP3, IL15
6	RAR-Gamma-RXR-Alpha Degradation36	11.5	UBB, UBC, IL15, IL16, ANGPT4, MAPK14
7	Influenza A20	11.5	PIK3CG, FURIN, JUN, GSK3B, IL12B, IL1A
8	Leishmaniasis20	11.4	JUN, ITGA4, IL10, IL12B, IL1A, IL1B
9	MIF Mediated Glucocorticoid Regulation36	11.4	BCL2, BAX, MIF, IL10, IL12B, IL15
10	PEDF Induced Signaling36	11.4	SERPINF1, BDNF, BCL2, BAX, IL10, IL12B
11	Immune response IL-1 signaling pathway10	11.3	SERPINE1, UBA52, UBB, JUN, IL1A, IL1B
12	DHA Signaling36	11.3	SEMA3A, SERPINF1, BDNF, BCL2, YWHAQ, BAX
13	MAPK Family Pathway36	11.3	SEMA3A, BDNF, BCL2, BAX, JUN, CD4
14	Tuberculosis20	11.2	BCL2, BAX, LBP, IL10, IL12B, IL1A
15	MAPK signaling pathway20	11.2	BDNF, JUN, IL1A, IL1B, FASLG, FAS
16	Glucocorticoid Receptor Signaling36	11.1	BCL2, BAX, JUN, CD4, IL10, IL12B
17	Amyotrophic lateral sclerosis (ALS)20	11.0	BCL2, BAX, GRIA2, MAPK14, GPX1, ALS2
18	Immune response_IL-1 signaling pathway41	11.0	SERPINE1, UBA52, UBB, UBC, JUN, IL1A
19	Toxoplasmosis20	11.0	PIK3CG, BCL2, LDLR, CD40, IL10, IL12B
20	all-trans-Retinoic Acid Signaling in Brain36	11.0	BCL2, BAX, IL10, IL12B, IL15, IL16
21	PAK Pathway36	10.9	SEMA3A, BDNF, BCL2, BAX, IL10, IL12B
22	African trypanosomiasis20	10.9	VCAM1, IL10, IL12B, IL1B, IL6, APOA1
23	Chagas disease (American trypanosomiasis)20	10.9	PIK3CG, SERPINE1, JUN, IL10, IL12B, IL1B
24	PGC1Alpha Pathway36	10.9	BCL2, BAX, CD4, INSR, IL12B, IL15
25	Toll-like receptor signaling pathway20	10.9	PIK3CG, LBP, JUN, CD40, IL12B, IL1B
26	Statin Pathway, Pharmacodynamics34	10.9	LRP1, LPL, LIPC, SCARB1, LDLR, LCAT
27	TGF-Beta Pathway36	10.8	SEMA3A, BDNF, BCL2, BAX, JUN, CD4
28	Chemokine Signaling36	10.7	JUN, IL8, MAPK8, MAPK3, MAPK14, MAPK10
29	MIF Regulation of Innate Immune Cells36	10.7	BCL2, BAX, JUN, MIF, IL10, IL12B
30	Immune response MIF-mediated glucocorticoid regulation10	10.7	VCAM1, JUN, MMP1, MIF, IL6, IL8
31	Immune response_MIF-mediated glucocorticoid regulation41	10.7	VCAM1, JUN, MMP1, MIF, IL6, IL8
32	Renin-Angiotensin Pathway36	10.2	SEMA3A, VCAM1, BDNF, JUN, IL2RA, IL6
33	Immune response MIF in innate immunity response10	9.9	LBP, JUN, MIF, IL1B, IL6, IL8
34	Immune response_MIF in innate immunity response41	9.9	LBP, JUN, MIF, IL1B, IL6, IL8
35	p70S6K Signaling36	9.8	SEMA3A, BDNF, YWHAQ, INS, INSR, IL2RA
36	Apoptotic Pathways Triggered By HIV136	9.8	BCL2, BAX, CD4, MAPK8, MAP3K14, MAPK10
37	Osteoclast differentiation20	INF	PIK3CG, JUN, IL1A, IL1B, MAPK8, MAP3K14
38	Molecular Mechanisms of Cancer36	INF	PIK3CG, SEMA3A, BDNF, BCL2, BAX, JUN
39	Cytokine-cytokine receptor interaction20	INF	VEGFA, CD27, CD40, IL10, IL12B, IL15
40	Rho Family GTPases36	INF	SEMA3A, BDNF, BCL2, BAX, JUN, ITGA4
41	JNK Pathway36	INF	BCL2, BAX, JUN, CD4, IL18R1, IL2RA
42	ERK Signaling36	INF	SEMA3A, ITGA4, ITGAL, INSR, IL10, IL12B
43	STAT3 Pathway36	INF	BCL2, BAX, CD4, IL10, IL12B, IL15
44	MAPK Signaling36	INF	SEMA3A, BDNF, BCL2, JUN, ITGA4, ITGAL
45	Antioxidant Action of Vitamin-C36	INF	SEMA3A, BDNF, BCL2, BAX, JUN, CD4
46	p38 Signaling36	INF	SEMA3A, BDNF, BCL2, BAX, CD4, INSR
47	Tec Kinases Signaling36	INF	SEMA3A, BDNF, BCL2, BAX, CD4, ITGA4
48	JAK-STAT Pathway36	INF	SEMA3A, BDNF, BCL2, UBB, UBC, BAX
49	Pathways in cancer20	INF	PIK3CG, VEGFA, BCL2, BCR, BAX, JUN
50	Endothelin-1 Signaling Pathway36	INF	INSR, IL10, IL12B, IL16, IL1A, IL1B

Compounds related to dementia according to GeneDecks:

(show top 50)    (show all 563)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	24.9	PIK3C2A, PIN1, LRP1, LRPAP1, PDE4A, RELN
2	cholesterol32 9 18 9	22.8	PIK3C2A, LRP1, LRP8, LRPAP1, RELN, CNBP
3	nitric oxide32 9 18 9	20.1	LRP8, NCAM1, PDE4A, SFTPD, SELP, SERPINF1
4	hydrogen32 18	17.4	PIN1, PDE4A, PCSK9, BDNF, BCR, CHGA
5	thymidine32 18	15.9	SFTPD, PCNA, SERPINA1, VIP, CLU, PAEP
6	cocaine32 9 9	16.5	PIK3C2A, PDE4A, SELP, VCAM1, BDNF, BCHE
7	proline32	14.0	PIN1, LPA, CLU, PARK2, BDNF, CHRNA7
8	cyclic amp32 18	14.8	PDE4A, SFTPD, BDNF, SCG2, SCARB1, CHGA
9	glucose32	13.8	PDE4A, SERPINF1, BLVRB, PARK2, SCG2, MT-ND1
10	chloramphenicol32 9 9	15.6	SERPINC1, SERPINE1, LPL, SDHB, CHGA, LDLR
11	sodium dodecylsulfate32	13.3	LRP1, VWF, SERPINE1, LPA, LPL, LIPC
12	copper32 18	14.2	PCSK7, SERPINA1, LPA, BACE1, MT3, MTR
13	silver32	13.2	PCNA, SERPINA3, BDNF, CHAT, CHGA, FMR1
14	levodopa32 9 9	14.8	PINK1, PARK7, BDNF, CHGA, CHKB, SAG
15	lactacystin32	12.7	PIK3CG, PARK2, BCL2, BACE1, JUN, CDKN1B
16	4-hydroxynonenal32 18	13.6	CHAT, LCAT, BACE1, BAX, JUN, MME
17	ceramide32	12.6	CLN3, PARK2, SCARB1, CHRM2, BACE1, CDKN1B
18	vitamin b1232	12.6	VWF, PCNA, SERPINA3, LPA, MTHFR, MTR
19	adenine32 9 18 9	15.4	VWF, NAT2, LDLR, MTHFR, S100B, CD38
20	vitamin-e32	12.4	PIK3C2A, LPA, VCAM1, SCARB1, LBR, B2M
21	6-hydroxydopamine32	12.3	VIP, PARK7, PARK2, BDNF, CHAT, CDK5
22	verapamil32 34 9 18 9	16.1	LRP1, VIP, LDLR, INSR, IL2RA, APOB
23	rotenone32	12.0	PIK3CG, PARK7, PARK2, BCL2, SDHB, MT-ND1
24	mg 13232 42	12.9	PIK3CG, PCNA, PARK2, BAX, JUN, CDKN1B
25	glycerol32 9 18 9	14.8	PIK3C2A, PDE4A, VWF, PCNA, SERPINC1, LPL
26	dithiothreitol32	11.8	VWF, LPA, SCG2, CHGB, FURIN, CD38
27	dihydrotestosterone32 9 18 9	14.8	SERPINE1, VIP, LPL, CLU, MSBP2, CD40
28	pentoxifylline32 9 9	13.8	PDE4A, SELP, VCAM1, LBR, CD9, ITGA4
29	n acetylcysteine32	11.7	VWF, PCNA, SELP, SERPINC1, VCAM1, CLU
30	rosiglitazone32 9 18 9	14.7	PIK3CG, LRP1, SERPINE1, LPA, LPL, VCAM1
31	l-nmma32	11.7	VIP, VCAM1, INSR, IL1RN, CAT, GH1
32	tetracycline32 9 9	13.6	VWF, FURIN, MMP1, MMP2, MMP9, MIF
33	endotoxin32	11.6	SFTPD, BLVRB, CHKB, LBP, MT3, SAA4
34	cerivastatin32 9 9	13.6	PIK3C2A, SERPINE1, CHKB, MMP1, APOA1, APOB
35	tamoxifen32 34 9 9	14.5	PDE4A, PCNA, SERPINC1, VEGFA, LPL, VCAM1
36	neopterin32	11.5	CHIT1, CHKB, LBR, SAA4, B2M, CD4
37	carbachol32 9 9	13.5	CHRM2, CHRM1, LBR, GRM1, GRP, MAPK10
38	p00332	11.4	SERPINA1, SERPINE1, LIPC, CHGA, S100B, CDKN1B
39	ionomycin32	11.4	SERPINA3, CD40, GSN, GRP, MAP2, MAPK3
40	camptothecin32 42 9 9	14.3	PIK3CG, PCNA, CLU, BDNF, BCL2, BAX
41	bromocriptine32 9 9	13.3	PIK3C2A, VIP, HTR1A, HTR2A, GH1, GHRH
42	hydrocortisone32 9 9	12.7	CD40, MMP1, MMP2, MIF, INS, INSR
43	ibuprofen32 9 18 9	13.7	VCAM1, BDNF, BACE1, MMP1, MMP2, MMP3
44	histidine32	INF	PDE4A, CHGA, MTR, S100B, AVP, FURIN
45	vitamin d32	INF	LRP1, SERPINE1, LPL, CLU, CHGA, CHKB
46	phorbol32	INF	CHGA, JUN, CD4, CD40, ITGAL, MMP1
47	atp32	INF	PINK1, PIK3C2A, NCAM1, PDE4A, CNBP, VCP
48	sodium32 18	INF	PIK3C2A, NCAM1, BLVRB, BDNF, CHAT, CHRNB2
49	pd 98,05932	INF	PIK3CG, PDE4A, SERPINE1, VCAM1, BDNF, BCL2
50	paraffin32	INF	NCAM1, VWF, PCNA, SERPINA1, SERPINA3, VEGFA

Cellular components related to dementia according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	INF	LRP1, SELP, SCARB2, SCARB1, CHRM2, CHRM1
2	plasma membrane	GO:005886	INF	PIK3C2A, PIK3CG, LRP8, LRPAP1, NCAM1, SELP
3	extracellular region	GO:005576	18.3	LRP8, LRPAP1, NCAM1, VWF, SFTPD, SERPINC1
4	cytosol	GO:005829	18.0	PINK1, PIK3C2A, PIK3CG, PDE4A, CNBP, PCBP2
5	extracellular space	GO:005615	16.0	RELN, SFTPD, PCSK9, PCSK1N, PCSK6, SELP
6	mitochondrion	GO:005739	14.1	PINK1, PCBP3, CLU, CLN3, CLN8, PARK7
7	perinuclear region of cytoplasm	GO:048471	14.1	PDE4A, PCSK9, VLDLR, CLU, CLN5, PARK2
8	endoplasmic reticulum	GO:005783	13.1	LRPAP1, CNBP, VWF, PCSK9, PCSK6, VCP
9	neuronal cell body	GO:043025	12.8	CHRM2, CHAT, CHRM4, CHRNA4, UCHL1, S100B
10	external side of plasma membrane	GO:009897	12.4	NCAM1, VWF, SELP, VCAM1, CHRNB2, CHRNA4
11	dendrite	GO:030425	12.0	RELN, SEMA3A, CHRM2, CHRNA4, AVP, CDK5
12	lysosome	GO:005764	11.9	SFTPD, PCSK9, CLN5, CLN3, CHIT1, LDLR
13	axon	GO:030424	11.8	SEMA3A, PARK7, CHAT, UCHL1, CDK5, MME
14	secretory granule	GO:030141	11.7	PCSK1N, VEGFA, SCG2, CHGB, CHGA, AVP
15	platelet alpha granule lumen	GO:031093	10.9	VWF, SERPINA1, SERPINE1, VEGFA, CLU, APP
16	cytoplasm	GO:005737	INF	PIK3C2A, PIK3CG, PIN1, LRP1, RELN, KIAA1217
17	cell surface	GO:009986	INF	LRPAP1, NCAM1, PCSK9, PCSK6, VLDLR, VEGFA

Biological processes related to dementia according to GeneDecks:

(show top 50)    (show all 51)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	15.7	PIK3C2A, PIK3CG, NCOA6, GCKR, NAT2, LPA
2	synaptic transmission	GO:007268	13.8	CHRNA7, CHAT, CHRNB2, CHRNA4, ATXN3, CDK5
3	proteolysis	GO:006508	13.5	LRP8, RELN, PCSK7, PCSK6, LPA, BLMH
4	response to drug	GO:042493	13.0	PDE4A, VLDLR, LPL, PARK7, BDNF, BCHE
5	nervous system development	GO:007399	12.9	VLDLR, VEGFA, CLN8, BDNF, CHRM2, CHRM1
6	response to hypoxia	GO:001666	12.9	SERPINA1, VEGFA, VCAM1, BCL2, CHRNA7, CHAT
7	positive regulation of transcription from RNA polymerase II promoter	GO:045944	12.7	NCOA6, CNBP, SERPINE1, VEGFA, UBA52, UBB
8	anti-apoptosis	GO:006916	12.5	BDNF, BCL2, UBA52, UBB, UBC, CD27
9	cholesterol metabolic process	GO:008203	12.5	PCSK9, VLDLR, LIPC, CLN6, CLN8, LDLR
10	G-protein coupled receptor signaling pathway	GO:007186	12.5	PIK3CG, VIP, CHRM2, CHRM1, CELSR2, INS
11	negative regulation of neuron apoptotic process	GO:043524	12.3	CLN3, PARK7, PARK2, BDNF, BCL2, BAX
12	activation of MAPK activity	GO:000187	12.3	CHRNA7, UBA52, UBB, UBC, CDK1, INSR
13	apoptotic process	GO:006915	12.3	PCSK9, SEMA3A, BCL2, UBA52, UBB, UBC
14	response to ethanol	GO:045471	12.2	BCL2, CHAT, CHRNB2, AVP, CD27, CDK1
15	blood coagulation	GO:007596	12.2	PIK3CG, LRP8, VWF, SELP, SERPINC1, SERPINA1
16	platelet activation	GO:030168	12.0	PIK3CG, VWF, SELP, SERPINA1, SERPINE1, VEGFA
17	response to organic cyclic compound	GO:014070	11.9	SELP, SERPINA1, JUN, CDK1, IL1A, IL1RN
18	aging	GO:007568	11.9	SERPINF1, VCAM1, FURIN, JUN, ASS1, GSN
19	platelet degranulation	GO:002576	11.8	VWF, SELP, SERPINA1, SERPINE1, VEGFA, CLU
20	lipid metabolic process	GO:006629	11.8	LRP8, LPA, LPL, LIPG, CLU, SCARB1
21	locomotory behavior	GO:007626	11.6	CHRNB2, CHRNA4, AVP, GRM1, APLP2, APP
22	response to wounding	GO:009611	11.6	VWF, CCR2, F2, CASP3, CTSB, NGFR
23	cholesterol homeostasis	GO:042632	11.5	PCSK9, LIPG, LIPC, SCARB1, LDLR, LCAT
24	cellular response to lipopolysaccharide	GO:071222	11.5	SERPINE1, VLDLR, LBP, ASS1, IL10, IL12B
25	response to lipopolysaccharide	GO:032496	11.5	SELP, SERPINA1, LBP, JUN, MMP9, IL1A
26	lipoprotein metabolic process	GO:042157	11.4	PCSK9, LPA, LPL, SCARB1, LDLR, LCAT
27	response to glucocorticoid stimulus	GO:051384	11.4	SERPINF1, SERPINE1, BCHE, LCAT, INSR, IL10
28	induction of apoptosis by extracellular signals	GO:008624	11.4	UBA52, UBB, UBC, BAX, CD38, FASLG
29	nerve growth factor receptor signaling pathway	GO:048011	11.4	PCSK6, UBA52, UBB, UBC, FURIN, CDKN1B
30	sensory perception of pain	GO:019233	11.3	CHRNB2, CHRNA4, CDK5, MME, GRM1, FAM134B
31	memory	GO:007613	11.3	VLDLR, CHRNA7, CHAT, CHRNB2, S100B, JPH3
32	lipopolysaccharide-mediated signaling pathway	GO:031663	11.2	SCARB1, LBP, IL1B, MAPK3, MAPK14, CCL2
33	reverse cholesterol transport	GO:043691	11.2	LIPG, LIPC, CLU, SCARB1, LCAT, CETP
34	response to estradiol stimulus	GO:032355	11.1	SERPINA1, MMP9, ASS1, INSR, IL1B, ENO2
35	adult walking behavior	GO:007628	11.0	CLN8, CHAT, UCHL1, ATG7, MAPT, CACNA1A
36	stress-activated MAPK cascade	GO:051403	11.0	UBA52, UBB, UBC, JUN, CDK1, MAPK8
37	response to copper ion	GO:046688	10.9	BCL2, LCAT, CDK1, IL1A, ICAM1, NFKB1
38	negative regulation of apoptotic process	GO:043066	10.9	PIK3CG, SERPINE1, VEGFA, CLU, CLN3, CLN8
39	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.6	CLU, UBA52, UBB, UBC, CD40, INS
40	acute-phase response	GO:006953	10.6	SERPINA1, SERPINA3, LBP, SAA4, ITIH4, ASS1
41	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.6	RELN, SELP, INS, CCL5, IGF1, F2
42	MAPK cascade	GO:000165	10.5	BRAP, SCG2, CDK1, INS, IL1B, MAPK3
43	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.4	LRP8, RELN, VEGFA, CD4, MIF, INS
44	neuron apoptotic process	GO:051402	10.2	BCL2, BAX, ATN1, CDK5, APP, FAS
45	positive regulation of cell proliferation	GO:008284	INF	CNBP, VIP, VEGFA, CHRNA7, CHRM1, AVP
46	cell death	GO:008219	INF	PINK1, , CLN5, CLN6, CLN3, CLN8
47	signal transduction	GO:007165	INF	LRP8, PDE4A, VLDLR, BCR, CHRNA7, CHRM1
48	cytokine-mediated signaling pathway	GO:019221	INF	PIN1, LRP8, NCAM1, VCAM1, UBA52, UBB
49	inflammatory response	GO:006954	INF	PIK3CG, SELP, SERPINA3, PARK7, SCG2, CD40
50	innate immune response	GO:045087	INF	PIK3CG, PIN1, SFTPD, PCBP2, CLU, BCL2

Molecular functions related to dementia according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	22.8	ACHE, TH, TGFB1, TGM2, TF, DNMBP
2	receptor binding	GO:005102	12.5	CX3CL1, NOS2, PLA2G1B, CRH, NRG1, TNFSF14
3	heparin binding	GO:008201	11.8	APOE, APOH, APP, CCL2, CCL5, PTPRC
4	enzyme binding	GO:019899	11.6	A2M, NOTCH3, PLCB1, PLAUR, PPARG, CYP2A6
5	cytokine activity	GO:005125	11.6	FASLG, CCL4, IFNA10, IFNG, TNF, TNFRSF11B
6	neuropeptide hormone activity	GO:005184	11.6	GAL, PENK, NPY, HCRT, CRH, NTS
7	identical protein binding	GO:042802	11.2	TNF, TP53, ESR1, GLUL, CALHM1, IGF1R
8	apolipoprotein binding	GO:034185	11.0	ABCA1, MAPT, SCARB1, LIPC, LPA, VLDLR
9	drug binding	GO:008144	10.5	DRD4, CYP2D6, PPARG, ACE, SLC6A3, SLC18A2
10	protease binding	GO:002020	9.7	TP53, TNF, TNFRSF1A, C10orf2, CST3, CSTB
11	protein homodimerization activity	GO:042803	INF	CCR2, SPPL2B, SP1, CTSE, NTRK2, NR3C1