MCID: DMN002
MIFTS: 66

Dementia malady

Summaries for Dementia

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Dementia is the name for a group of symptoms caused by disorders that affect the brain. it is not a specific disease. people with dementia may not be able to think well enough to do normal activities, such as getting dressed or eating. they may lose their ability to solve problems or control their emotions. their personalities may change. they may become agitated or see things that are not there. memory loss is a common symptom of dementia. however, memory loss by itself does not mean you have dementia. people with dementia have serious problems with two or more brain functions, such as memory and language. although dementia is common in very elderly people, it is not part of normal aging. many different diseases can cause dementia, including alzheimer's disease and stroke. drugs are available to treat some of these diseases. while these drugs cannot cure dementia or repair brain damage, they may improve symptoms or slow down the disease. nih: national institute of neurological disorders and stroke

MalaCards: Dementia is related to frontotemporal dementia and vascular dementia. An important gene associated with Dementia is ITM2B (integral membrane protein 2B), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Neuroscience. The drugs citalopram and citalopram hydrobromide and the compounds serine and glutamine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are behavior/neurological and nervous system.

Disease Ontology:8 A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.

NINDS:43 Dementia is not a specific disease. It is a descriptive term for a collection of symptoms that can be caused by a number of disorders that affect the brain. People with dementia have significantly impaired intellectual functioning that interferes with normal activities and relationships. They also lose their ability to solve problems and maintain emotional control, and they may experience personality changes and behavioral problems, such as agitation, delusions, and hallucinations. While memory loss is a common symptom of dementia, memory loss by itself does not mean that a person has dementia. Doctors diagnose dementia only if two or more brain functions - such as memory and language skills -- are significantly impaired without loss of consciousness.

Wikipedia:63 Dementia (taken from Latin, originally meaning \"madness\", from de- \"without\" + ment, the root of... more...

Aliases & Classifications for Dementia

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8Disease Ontology, 43NINDS, 44Novoseek, 33MedlinePlus, 60UMLS, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

dementia 8 43 44 33 60


External Ids:

Disease Ontology8 DOID:1307
MeSH34 D003704
ICD9CM27 290.8

Related Diseases for Dementia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 494)
idRelated DiseaseScoreTop Affiliating Genes
1frontotemporal dementia31.8PSEN1, MAPT
2vascular dementia31.7APOE
3alzheimer's disease31.6ACHE, RPS27A, APP, APOE, PSEN1, CTSB
4lewy body dementia31.5APP, RPS27A, APOE, ACHE, SNCA, MAPT
5parkinson's disease31.2RPS27A, VCP, ACHE, MAPT, ATXN2, SNCA
6amyotrophic lateral sclerosis31.1SNCA, PSEN1, APP, RPS27A, MAPT, VCP
7lateral sclerosis31.0SNCA, MAPT
8motor neuron disease30.9SNCA, VCP, MAPT, GRN, RPS27A
9aphasia30.9C9orf72, GRN, MAPT
10brain disease30.8SERPINI1, SNCA, MAPT, PSEN1, APP
11pick's disease30.8MAPT, PSEN1
12cadasil30.8PSEN1, APOE, MAPT, SERPINI1
13cerebrovascular disease30.7ACHE, APP, APOE
14hydrocephalus30.7MAPT
15progressive supranuclear palsy30.7MAPT, GRN, APOE
16cerebral amyloid angiopathy30.7APOE, PSEN1, ITM2B, APP, MAPT
17tauopathy30.6RPS27A, APP, PSEN1, SNCA, GRN, MAPT
18myopathy30.6RPS27A, APP, ACHE, VCP
19schizophrenia30.6PSEN1, ATN1, SNCA, ACHE
20down syndrome30.5SNCA, PSEN1, ACHE, MAPT, APOE, APP
21multiple system atrophy30.5RPS27A, MAPT, SNCA
22rem sleep behavior disorder30.5SNCA
23binswanger's disease30.5APP, ACHE, APOE
24diabetes mellitus30.4APOE
25semantic dementia30.4RPS27A, GRN, MAPT
26huntington's disease30.3RPS27A, ACHE, SERPINI1, MAPT, ATN1, SNCA
27apraxia30.3GRN, MAPT
28encephalitis30.3APP
29amyloidosis30.2CTSB, APOE, PSEN1, MAPT, RPS27A, ITM2B
30dementia familial british30.2ITM2B, APP, SERPINI1
31prion disease30.2APP, PSEN1, MAPT
32olivopontocerebellar atrophy30.2SNCA, ATXN2
33paget's disease of bone30.2VCP
34ischemia30.1SNCA, PSEN1, SERPINI1, MAPT
35multiple sclerosis30.1APOE
36cerebellar ataxia30.1ATXN2
37alzheimer disease type 230.0MAPT, PSEN1, APOE, APP
38primary progressive aphasia30.0MAPT, GRN, RPS27A
39neuroaxonal dystrophy30.0SNCA, RPS27A
40creutzfeldt-jakob syndrome29.9APOE, SNCA, MAPT, APP, RPS27A
41spinocerebellar ataxia29.9ATXN2
42striatonigral degeneration29.9RPS27A, SNCA
43frontotemporal lobar degeneration with ubiquitin-positive inclusions29.9GRN
44essential tremor29.9SNCA
45glaucoma29.8ACHE
46amyloid tumor29.6MAPT, ACHE, APOE, PSEN1, RPS27A, APP
47astrocytoma29.6SNCA, CTSB, PSEN1, APP
48niemann-pick disease29.6APP, SNCA, MAPT
49dentatorubral-pallidoluysian atrophy29.5ATXN2, ATN1
50neuronal intranuclear inclusion disease29.5RPS27A

Graphical network of the top 20 diseases related to Dementia:



Diseases related to dementia

Clinical Features for Dementia

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Drugs & Therapeutics for Dementia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Dementia

Drug clinical trials:

Search ClinicalTrials for Dementia

Search NIH Clinical Center for Dementia

Search CenterWatch for Dementia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Dementia

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Anatomical Context for Dementia

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32MalaCards
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MalaCards organs/tissues related to Dementia:

32
Brain, Cortex, Testes, Bone, Temporal lobe, Heart, Monocytes, Eye, T cells, Endothelial, Skin, Amygdala, Spinal cord, Prefrontal cortex, Thalamus, Caudate nucleus, B cells, Cerebellum, Hypothalamus, Thyroid, Spleen, Parietal lobe, Kidney, Liver, Pituitary

Animal Models for Dementia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dementia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538612.6SERPINI1, APP, APOE, PSEN1, CTSB, SNCA
2MP:000363112.4SNCA, CTSB, PSEN1, APOE, APP, ITM2B
3MP:001076812.3APP, APOE, PSEN1, CTSB, SNCA, ATXN2
4MP:000537811.9APP, APOE, PSEN1, CTSB, SNCA, ATXN2
5MP:000301211.8APP, APOE, SNCA, ITM2B, ATN1, GRN
6MP:000538411.8APOE, PSEN1, CTSB, SNCA, GRN, TRPM7
7MP:000538911.7APP, APOE, PSEN1, SNCA, ATXN2, ATN1
8MP:000538711.7APP, APOE, PSEN1, CTSB, SNCA, GRN
9MP:000539511.3APP, APOE, PSEN1, CTSB, MAPT
10MP:001077111.2APP, APOE, PSEN1, CTSB, SNCA, MAPT

Publications for Dementia

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Sources:
50PubMed
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Articles related to Dementia:

(show top 50)    (show all 4239)
idTitleAuthorsYear
1
Immunological Aspects and Anti-Amyloid Strategy for Alzheimer's Dementia / IMUNOLOA KI ASPEKTI I ANTIAMILOIDNE STRATEGIJE ZA ALZHEIMEROVU DEMENCIJU. (24384767)
2013
2
Frailty syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Aging. (23245560)
2013
3
Introducing a Latin ballroom dance class to people with dementia living in care homes, benefits and concerns: A pilot study. (24337327)
2013
4
Bilingualism delays age at onset of dementia, independent of education and immigration status. (24198291)
2013
5
Mitochondrial bioenergetic deficits in the hippocampi of rats with chronic ischemia-induced vascular dementia. (23232258)
2013
6
Excessive TV watching in patients with frontotemporal dementia. (22827619)
2013
7
Identifying risk for dementia across populations: A study on the prevalence of dementia in tribal elderly population of Himalayan region in Northern India. (24339597)
2013
8
Cerebrolysin for vascular dementia. (23440834)
2013
9
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. (22406228)
2012
10
Reversal of pathology in CHMP2B-mediated frontotemporal dementia patient cells using RNA interference. (22786763)
2012
11
Association of cerebral emboli with accelerated cognitive deterioration in Alzheimer's disease and vascular dementia. (22193532)
2012
12
Frontal cortex neuropathology in dementia pugilistica. (22017610)
2012
13
Open-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementia. (21792308)
2011
14
Decision-making in frontotemporal dementia: clinical, theoretical and legal implications. (21822019)
2011
15
Relationship between occupation attributes and brain metabolism in frontotemporal dementia. (21958648)
2011
16
TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease. (20361198)
2010
17
Computational modeling of reading in semantic dementia: comment on Woollams, Lambon Ralph, Plaut, and Patterson (2007). (20063972)
2010
18
The utility of placing recollection in opposition to familiarity in early discrimination of healthy aging and very mild dementia of the Alzheimer's type. (20063946)
2010
19
Cholinergic imaging in corticobasal syndrome, progressive supranuclear palsy and frontotemporal dementia. (20558417)
2010
20
Presymptomatic generalized brain atrophy in frontotemporal dementia caused by CHMP2B mutation. (19202337)
2009
21
The value of quantitative EEG in differential diagnosis of Alzheimer's disease and subcortical vascular dementia. (19268969)
2009
22
The role of proteomics in dementia and Alzheimer's disease. (19259691)
2009
23
"I remember it as if it were yesterday": memory for recent events in patients with semantic dementia. (19428398)
2009
24
Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats. (18691432)
2008
25
Cognitive decline as a manifestation of mitochondrial disorders (mitochondrial dementia). (18572195)
2008
26
The prevention of the dementia epidemic. (17490685)
2007
27
Brain type carnosinase in dementia: a pilot study. (17983474)
2007
28
Neurocognitive differential diagnosis of dementing diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. (17000529)
2006
29
High prevalence of Chlamydia pneumoniae antibodies and increased high-sensitive C-reactive protein in patients with vascular dementia. (15817002)
2005
30
The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies. (15616167)
2004
31
Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI. (15263903)
2004
32
Evaluation of CSF glial fibrillary acidic protein (GFAP) as a putative marker for HIV-associated dementia. (15007738)
2004
33
Are the Danish Society of General Practitioners' clinical guidelines concerning "Identification and investigation of dementia and dementia-like conditions" useful as the basis of dementia investigation in general practice?]. (12812104)
2003
34
Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia. (14512714)
2003
35
Is surface dysgraphia tied to semantic impairment? Evidence from a case of semantic dementia. (12030487)
2002
36
Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia? (11746411)
2001
37
Frontotemporal dementia with motor neuron disease (amyotrophic lateral sclerosis with dementia). (10935441)
2000
38
A Japanese patient with frontotemporal dementia and parkinsonism by a tau P301S mutation. (11071507)
2000
39
A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy. (10412802)
1999
40
Pick's disease, frontotemporal dementia, and Pick complex: emerging concepts. (9520003)
1998
41
Dementia of frontal type and dementias with subcortical gliosis. (9546290)
1998
42
Tacrine efficacy in Lewy body dementia. (9733331)
1998
43
A unique familial leukodystrophy with adult onset dementia and abnormal glycolipid storage: a new lysosomal disease? (9703182)
1998
44
Qualitative assessment of cerebral atrophy on MRI: inter- and intra-observer reproducibility in dementia and normal aging. (9058064)
1997
45
Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease. (7992850)
1994
46
Adult ChAcdiak-Higashi syndrome presenting as parkinsonism and dementia. (8030398)
1994
47
Familial Pick's disease and dementia in frontal lobe degeneration of non-Alzheimer type are not variants of prion disease. (8006666)
1994
48
Calbindin D-28k and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis. (8459241)
1993
49
Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex: an immunohistochemical study. (2161095)
1990
50
Other neurologic diseases with dementia as a sequela. (3066461)
1988

Genetic Variations for Dementia

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Expression for genes affiliated with Dementia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dementia

Search GEO for disease gene expression data for Dementia.

Pathways for genes affiliated with Dementia

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN, 52R&D Systems
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Compounds for genes affiliated with Dementia

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1serine4412.5RPS27A, APP, APOE, PSEN1, CTSB, SNCA
2glutamine4412.4PSEN1, APOE, APP, RPS27A, CTSB, SNCA
3cysteine4412.2RPS27A, APP, APOE, PSEN1, CTSB, SNCA
4glutamate4412.0RPS27A, APP, APOE, PSEN1, CTSB, SNCA
5valine4411.9RPS27A, APP, APOE, PSEN1, CTSB, SNCA
6h2o24411.9RPS27A, APP, APOE, PSEN1, CTSB, SNCA
7arginine4411.8RPS27A, APP, APOE, PSEN1, CTSB, SNCA
8alanine4411.8RPS27A, APP, APOE, PSEN1, CTSB, SNCA
94-hydroxynonenal44 2412.8RPS27A, APP, APOE, PSEN1, SNCA, MAPT
10lactacystin4411.8RPS27A, APP, APOE, PSEN1, SNCA, MAPT
11carbachol44 28 1113.8APP, PSEN1, CTSB, SNCA, MAPT, ACHE
12nmda44 2812.8RPS27A, APP, APOE, PSEN1, MAPT, ACHE
13acetylcholine44 49 28 11 2415.7RPS27A, APP, APOE, SNCA, MAPT, ACHE
14aspartate4411.7RPS27A, APP, APOE, PSEN1, CTSB, MAPT
15testosterone44 59 11 2414.7MAPT, ATN1, SNCA, APOE, APP, RPS27A
16thioflavine s4411.6MAPT, SNCA, APOE, APP, RPS27A
17formate4411.6RPS27A, APP, APOE, SNCA, MAPT
18chloroquine44 2 49 28 1115.6RPS27A, APP, APOE, CTSB, MAPT
19sodium dodecylsulfate4411.6RPS27A, APP, APOE, SNCA, MAPT
20choline44 11 2413.6ACHE, MAPT, SNCA, PSEN1, APP
21actinomycin d4411.5MAPT, CTSB, APOE, APP, RPS27A
22tacrine44 1112.5APP, APOE, MAPT, ACHE
23paraffin4411.5RPS27A, APOE, CTSB, SNCA, MAPT
24donepezil44 11 2413.5ACHE, MAPT, APOE, APP
25galantamine44 49 1113.5ACHE, MAPT, APOE, APP
26atropine44 28 1113.4APP, CTSB, SNCA, ACHE
27guanidine hydrochloride4411.4SNCA, CTSB, APOE, RPS27A
28kainate44 2812.4APOE, PSEN1, CTSB, MAPT
29biotin44 11 2413.4CTSB, PSEN1, APOE, RPS27A
30threonine4411.3RPS27A, PSEN1, CTSB, TRPM7, MAPT, VCP
31folate4411.3APP, APOE, PSEN1, MAPT
32thioflavin4411.3APP, SNCA, MAPT
33nicotine44 49 28 1114.3ACHE, MAPT, APOE, APP
34metrifonate4411.3APP, APOE, ACHE
35thapsigargin44 5912.3APP, PSEN1, CTSB, VCP
36thioflavin t4411.3APP, APOE, SNCA
37memantine44 28 1113.3APP, MAPT, ACHE
38dopamine44 28 11 2414.3SNCA, APP, RPS27A
39hydrogen44 2412.2SNCA, CTSB, PSEN1, RPS27A
40spec-t4411.2APOE, PSEN1, MAPT
41creatinine4411.2MAPT, CTSB, APOE, APP, RPS27A
42cyclosporin a44 28 5913.1CTSB, APP, RPS27A
43phenserine44 5912.1APP, ACHE
446-hydroxydopamine4411.1RPS27A, APP, SNCA
45huperzine a4411.0APP, ACHE
46rivastigmine44 1112.0APOE, ACHE
47ddvp4410.9ACHE, APP
48tmao4410.8MAPT, SNCA
4924s-hydroxy-cholesterol4410.7APP, APOE
50ginkgo4410.5APP, ACHE

GO Terms for genes affiliated with Dementia

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Sources:
16Gene Ontology
See all sources

Cellular components related to Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00579411.8ACHE, APP, APOE, FAM134B, PSEN1, SNCA
2perinuclear region of cytoplasmGO:04847111.6APP, PSEN1, CTSB, SNCA, ATXN2, ATN1
3axonGO:03042411.3APP, PSEN1, SNCA, MAPT, ACHE
4intracellular membrane-bounded organelleGO:04323111.3APP, CTSB, ITM2B, GRN, VCP
5extracellular spaceGO:00561511.2APOE, CTSB, ITM2B, GRN, ACHE, SERPINI1
6neuromuscular junctionGO:03159410.9ACHE, PSEN1, APP
7growth coneGO:03042610.9MAPT, SNCA, PSEN1
8ciliary rootletGO:03525310.5PSEN1, APP

Biological processes related to Dementia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cell deathGO:00821911.6TRPM7, GRN, CHMP2B, C9orf72, ATXN2, APOE
2neuron apoptotic processGO:05140211.1ATN1, PSEN1, APP
3positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243611.1VCP, NUB1, PSEN1
4smooth endoplasmic reticulum calcium ion homeostasisGO:05156311.0APP, PSEN1
5negative regulation of neuron apoptotic processGO:04352410.9SNCA, PSEN1, APOE
6positive regulation of receptor recyclingGO:00192110.9PSEN1, SNCA
7axon cargo transportGO:00808810.8MAPT, APP
8positive regulation of axon extensionGO:04577310.8MAPT, APOE
9synaptic transmission, cholinergicGO:00727110.7APOE, ACHE
10Notch signaling pathwayGO:00721910.6PSEN1, APP, RPS27A

Molecular functions related to Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.0APP, APOE, PSEN1, CTSB, SNCA, ITM2B
2protein domain specific bindingGO:01990411.1VCP, CHMP2B, ATN1, SNCA
3beta-amyloid bindingGO:00154011.0ACHE, ITM2B, APOE
4tau protein bindingGO:04815610.8SNCA, APOE
5lipoprotein particle bindingGO:07181310.7APOE, MAPT

Products for genes affiliated with Dementia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet