MCID: DMN002
MIFTS: 58

Dementia malady

Mental diseases category

Summaries for Dementia

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MedlinePlus:32 Dementia is the name for a group of symptoms caused by disorders that affect the brain. it is not a specific disease. people with dementia may not be able to think well enough to do normal activities, such as getting dressed or eating. they may lose their ability to solve problems or control their emotions. their personalities may change. they may become agitated or see things that are not there. memory loss is a common symptom of dementia. however, memory loss by itself does not mean you have dementia. people with dementia have serious problems with two or more brain functions, such as memory and language. although dementia is common in very elderly people, it is not part of normal aging. many different diseases can cause dementia, including alzheimer's disease and stroke. drugs are available to treat some of these diseases. while these drugs cannot cure dementia or repair brain damage, they may improve symptoms or slow down the disease. nih: national institute of neurological disorders and stroke

MalaCards based summary: Dementia, also known as presenile dementia, is related to vascular dementia and semantic dementia. An important gene associated with Dementia is MAPT (microtubule-associated protein tau), and among its related pathways are Fanconi anemia pathway and Reelin Pathway (Cajal-Retzius cells). The drugs citalopram and prochlorperazine and the compounds thioflavin and phenserine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are other and taste/olfaction.

Disease Ontology:9 A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.

NINDS:42 Dementia is not a specific disease. It is a descriptive term for a collection of symptoms that can be caused by a number of disorders that affect the brain. People with dementia have significantly impaired intellectual functioning that interferes with normal activities and relationships. They also lose their ability to solve problems and maintain emotional control, and they may experience personality changes and behavioral problems, such as agitation, delusions, and hallucinations. While memory loss is a common symptom of dementia, memory loss by itself does not mean that a person has dementia. Doctors diagnose dementia only if two or more brain functions - such as memory and language skills -- are significantly impaired without loss of consciousness.

Wikipedia:63 Dementia is a broad category of brain diseases that cause a long term and often gradual decrease in the... more...

Aliases & Classifications for Dementia

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Sources:
9Disease Ontology, 42NINDS, 43Novoseek, 32MedlinePlus, 60UMLS, 33MeSH, 27ICD9CM
See all sources

Dementia, Aliases & Descriptions:

Name: Dementia 9 42 43 32 60
 
Presenile Dementia 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology9 DOID:1307
MeSH33 D003704
ICD9CM27 290.8

Related Diseases for Dementia

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Diseases related to Dementia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 544)
idRelated DiseaseScoreTop Affiliating Genes
1vascular dementia32.6APOE
2semantic dementia32.0GRN, MAPT, RPS27A
3lateral sclerosis31.7SNCA, MAPT
4dementia, frontotemporal31.5PSEN1, MAPT
5rem sleep behavior disorder31.4SNCA
6dementia, lewy body31.3MAPT, SNCA, APOE
7aphasia31.2TARDBP, GRN, MAPT, C9orf72
8cerebrovascular disease31.2ACHE, APP, APOE
9pick disease31.1PSEN1, MAPT
10dementia, familial british31.1APP, ITM2B
11binswanger's disease31.1ACHE, APP, APOE
12multiple system atrophy31.1SNCA, RPS27A, MAPT
13cerebral amyloid angiopathy31.1APOE, APP, PSEN1, ITM2B, MAPT
14frontotemporal lobar degeneration with ubiquitin-positive inclusions31.0RPS27A, MAPT, GRN
15myopathy30.9RPS27A, ACHE, VCP, APP
16prion disease30.8APP, PSEN1, MAPT
17apraxia30.8MAPT, GRN
18motor neuron disease30.8VCP, SNCA, RPS27A, MAPT, GRN, TARDBP
19olivopontocerebellar atrophy30.7ATXN2, SNCA
20tauopathy30.7APP, PSEN1, SNCA, RPS27A, MAPT, GRN
21hereditary cerebral amyloid angiopathy30.7APP
22neuroaxonal dystrophy30.6SNCA, RPS27A
23down syndrome30.6APOE, APP, PSEN1, ACHE, SNCA, MAPT
24dentatorubro-pallidoluysian atrophy30.5ATXN2, ATN1
25creutzfeldt-jakob disease30.5APOE, APP, SNCA, RPS27A, MAPT
26brain disease30.5MAPT, SNCA, PSEN1, APP
27schizophrenia30.5SNCA, ACHE, PSEN1, ATN1
28neuronal intranuclear inclusion disease30.4RPS27A
29brain ischemia30.4APP, MAPT, CTSB
30alzheimer disease-230.4APOE, APP, PSEN1, MAPT
31striatonigral degeneration30.3SNCA, RPS27A
32supranuclear palsy, progressive30.3APOE, MAPT, GRN, TARDBP
33spinocerebellar ataxia 730.3ATXN2
34spinocerebellar ataxia30.2ATXN2, ATN1, SNCA, RPS27A, MAPT
35niemann-pick disease, type c130.2MAPT, SNCA, APP
36spinocerebellar ataxia 1230.2ATN1, ATXN2
37spinocerebellar ataxia 1730.1ATN1, ATXN2
38parkinson disease, late-onset30.1MAPT, RPS27A, SNCA, APOE
39amyloidosis30.1CTSB, MAPT, RPS27A, SNCA, ITM2B, PSEN1
40machado-joseph disease30.0ATXN2, ATN1, VCP, SNCA, RPS27A
41alzheimer disease30.0APP, APOE, VCP, PSEN1, ACHE, ITM2B
42huntington disease30.0ATN1, APP, PSEN1, ACHE, SNCA, RPS27A
43pure autonomic failure29.9SNCA, ACHE
44astrocytoma29.8APP, PSEN1, SNCA, CTSB
45amyotrophic lateral sclerosis 129.2VCP, CHMP2B, PSEN1, SNCA, RPS27A, MAPT
46aids dementia complex10.9
47cerebritis10.8
48neuronitis10.8
49cadasil10.6
50inclusion body myositis10.6APP

Graphical network of the top 20 diseases related to Dementia:



Diseases related to dementia

Symptoms for Dementia

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Drugs & Therapeutics for Dementia

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Drug clinical trials:

Search ClinicalTrials for Dementia

Search NIH Clinical Center for Dementia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Dementia

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Anatomical Context for Dementia

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MalaCards organs/tissues related to Dementia:

31
Brain, Cortex, Testes, Bone, Temporal lobe, Heart, Monocytes, Eye, Skin, T cells, Endothelial, Prefrontal cortex, Spinal cord, Thalamus, Amygdala, Cerebellum, B cells, Hypothalamus, Caudate nucleus, Spleen, Kidney, Liver, Thyroid, Parietal lobe, Pituitary

Animal Models for Dementia or affiliated genes

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Publications for Dementia

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Articles related to Dementia:

(show top 50)    (show all 4461)
idTitleAuthorsYear
1
An Exploratory Study of Grief and Health-Related Quality of Life for Caregivers of People With Dementia. (24381138)
2013
2
Posttraumatic stress disorder exacerbation with cholinesterase inhibitor in a patient with dementia. (24307975)
2013
3
Immunological Aspects and Anti-Amyloid Strategy for Alzheimer's Dementia / IMUNOLOA KI ASPEKTI I ANTIAMILOIDNE STRATEGIJE ZA ALZHEIMEROVU DEMENCIJU. (24384767)
2013
4
Attachment and coping of dementia care staff: The role of staff attachment style, geriatric nursing self-efficacy, and approaches to dementia in burnout. (24339071)
2013
5
Dementia Care in Nursing Barker Sue Board Michele Dementia Care in Nursing 184pp AL18.99 Sage 9780857258014 085725801X [Formula: see text]. (24283316)
2013
6
Evaluation of an education intervention to implement a capability model of dementia care. (24339075)
2013
7
The contribution of twins to the study of cognitive ageing and dementia: The Older Australian Twins Study. (24423226)
2013
8
The effectiveness of dyadic interventions for people with dementia and their caregivers. (24337642)
2013
9
Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia. (22335970)
2012
10
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies. (22226802)
2012
11
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. (22406228)
2012
12
I+-Synuclein mRNA and soluble I+-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease. (22560502)
2012
13
Phenotypic signatures of genetic frontotemporal dementia. (21986680)
2011
14
Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin. (21185921)
2011
15
Reverse concreteness effects are not a typical feature of semantic dementia: evidence for the hub-and-spoke model of conceptual representation. (21285258)
2011
16
Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)
2011
17
Clinical profiles of late-onset semantic dementia, compared with early-onset semantic dementia and late-onset Alzheimer's disease. (21447109)
2011
18
Clinical staging and disease progression in frontotemporal dementia. (20479357)
2010
19
Frontotemporal dementia phenotype associated with MAPT gene duplication. (20634582)
2010
20
Interleukin-1 beta (C-511T) genetic polymorphism is associated with cognitive performance in elderly males without dementia. (19013689)
2010
21
Inclusion body myopathy and frontotemporal dementia caused by a novel VCP mutation. (17889967)
2009
22
Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. (19073835)
2009
23
No association of common VCP variants with sporadic frontotemporal dementia. (17618707)
2009
24
Minimally invasive surgical approach for three-vessel occlusion as a model of vascular dementia in the rat-brain bioenergetics assay. (19272617)
2009
25
Expert opinion on the management of behavioural and psychological symptoms of dementia (BPSD) and investigation into prescribing practices in the UK. (19156700)
2009
26
Small vessel versus large vessel vascular dementia: risk factors and MRI findings. (18677637)
2008
27
Communication impairment in the AIDS dementia complex (ADC): a case report. (18242630)
2008
28
Defining "prodromal" Alzheimer's disease, frontotemporal dementia, and Lewy body dementia: are we there yet? (18327642)
2008
29
Nitrosative stress with HIV dementia causes decreased L-prostaglandin D synthase activity. (18077799)
2008
30
Statins and dementia. (17877925)
2007
31
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
32
Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer's type in an elderly Arab population in Wadi Ara, Israel. (18568123)
2005
33
Jargon dyslexia in an individual with semantic dementia: further evidence for task-specificity in phonological output. (16251136)
2005
34
Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease: a comparison. (15136683)
2004
35
A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. (14746899)
2004
36
The contribution of autobiographical significance to semantic memory: evidence from Alzheimer's disease, semantic dementia, and amnesia. (14615074)
2004
37
The role of viruses and of APOE in dementia. (15246985)
2004
38
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. (12364720)
2002
39
Hyperphosphorylated tau deposition parallels prion protein burden in a case of Gerstmann-StrAoussler-Scheinker syndrome P102L mutation complicated with dementia. (12200619)
2002
40
Hypersensitive mousetraps, alpha1-antitrypsin deficiency and dementia. (12023831)
2002
41
Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia--an epidemiological study using the polymerase chain reaction (PCR) method. (10860300)
2000
42
Search for a mutation in the tau gene in a Swiss family with frontotemporal dementia. (10683298)
2000
43
A stop-codon mutation in the BRI gene associated with familial British dementia. (10391242)
1999
44
Motor neuron disease-inclusion dementia presenting as cortical-basal ganglionic degeneration. (10435507)
1999
45
Vasodilator responses to acetazolamide tested in subtypes of vascular dementia. (17895108)
1998
46
Dementia pugilistica and cavum septi pellucidi: born to box? (9421861)
1997
47
Diagnosing Alzheimer's disease in very elderly patients. Relevance of some functional and psychobehavioral aspects assessed by the Gottfries-BrAYne-Steen Rating Scale for Dementia. Study Group on Brain Aging, Italian Society of Gerontology and Geriatrics. (9386985)
1997
48
Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins. (7717459)
1995
49
Review of antiretroviral therapy in the prevention of HIV-related AIDS dementia complex (ADC). (7614899)
1995
50
Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex: an immunohistochemical study. (2161095)
1990

Variations for Dementia

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Expression for genes affiliated with Dementia

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Search GEO for disease gene expression data for Dementia.

Pathways for genes affiliated with Dementia

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Pathways related to Dementia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0RPS27A, VCP
29.9MAPT, APP, APOE
39.8CTSB, PSEN1, APP
49.6APOE, APP, PSEN1, MAPT
5
Show member pathways
Alzheimers Disease36
9.0MAPT, SNCA, MT-ATP6, PSEN1, APP, APOE
68.9APOE, APP, CHMP2B, ITM2B, SNCA, RPS27A
78.8APOE, APP, PSEN1, SNCA, MAPT, TARDBP

Compounds for genes affiliated with Dementia

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Compounds related to Dementia according to GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1thioflavin4310.2APP, SNCA, MAPT
2phenserine43 5911.2ACHE, APP
3memantine43 28 49 1213.1APP, ACHE, MAPT
4thioflavin t4310.1SNCA, APP, APOE
5metrifonate4310.0APOE, APP, ACHE
6spec-t4310.0MAPT, PSEN1, APOE
7tmao4310.0MAPT, SNCA
8huperzine a439.9ACHE, APP
9tacrine43 1210.9MAPT, ACHE, APP, APOE
10donepezil43 49 24 1212.9APOE, APP, ACHE, MAPT
11galantamine43 49 1211.9MAPT, ACHE, APP, APOE
12rivastigmine43 1210.9ACHE, APOE
136-hydroxydopamine439.9RPS27A, SNCA, APP
14kainate43 2810.8CTSB, MAPT, PSEN1, APOE
15folate439.8APOE, APP, PSEN1, MAPT
16chloroquine43 2 49 28 1213.8APOE, APP, RPS27A, MAPT, CTSB
17atropine43 28 1211.7APP, ACHE, SNCA, CTSB
18guanidine hydrochloride439.7APOE, SNCA, RPS27A, CTSB
19thioflavine s439.7MAPT, RPS27A, SNCA, APP, APOE
20biotin43 24 1211.7APOE, PSEN1, RPS27A, CTSB
21formate439.7APOE, APP, SNCA, RPS27A, MAPT
22thapsigargin43 5910.7CTSB, PSEN1, VCP, APP
23nicotine43 28 49 1212.7APOE, APP, ACHE, MAPT
24sodium dodecylsulfate439.7APOE, APP, SNCA, RPS27A, MAPT
25actinomycin d439.7APOE, APP, RPS27A, MAPT, CTSB
26cyclosporin a43 28 5911.6APOE, APP, RPS27A, MAPT, CTSB
27ddvp439.6ACHE, APP
28choline43 24 1211.5APP, PSEN1, ACHE, SNCA, MAPT
29creatinine439.5APOE, APP, RPS27A, MAPT, CTSB
30paraffin439.5APOE, SNCA, RPS27A, MAPT, CTSB
314-hydroxynonenal43 2410.4APOE, APP, PSEN1, SNCA, RPS27A, MAPT
32lactacystin439.4APOE, APP, PSEN1, SNCA, RPS27A, MAPT
33heparin43 28 24 1212.4APOE, APP, SNCA, MAPT, CTSB
34aspartate439.4APOE, APP, PSEN1, RPS27A, MAPT, CTSB
35hydrogen43 2410.4PSEN1, MT-ATP6, SNCA, RPS27A, CTSB
36testosterone43 59 24 1212.4ATN1, APOE, APP, SNCA, RPS27A, MAPT
37carbachol43 28 1211.3APP, PSEN1, ACHE, SNCA, MAPT, CTSB
38threonine439.3VCP, PSEN1, RPS27A, MAPT, CTSB, TRPM7
39acetylcholine43 49 28 24 1213.3APOE, APP, ACHE, SNCA, RPS27A, MAPT
40dopamine43 28 24 1212.3APOE, APP, ACHE, SNCA, RPS27A, MAPT
41valine439.2APOE, APP, PSEN1, SNCA, RPS27A, MAPT
42h2o2439.1APOE, APP, PSEN1, SNCA, RPS27A, MAPT
43cycloheximide439.1APOE, PSEN1, RPS27A, MAPT, CTSB
44nmda43 2810.1APOE, APP, PSEN1, ACHE, RPS27A, MAPT
45arginine439.1APOE, APP, PSEN1, SNCA, RPS27A, MAPT
46alanine439.1APOE, APP, PSEN1, SNCA, RPS27A, MAPT
47glutamate438.8APOE, APP, PSEN1, ACHE, SNCA, RPS27A
48cysteine438.6ATN1, APOE, APP, PSEN1, SNCA, RPS27A
49glutamine438.5APP, APOE, ATN1, ATXN2, VCP, PSEN1
50serine438.3APOE, APP, VCP, PSEN1, ACHE, SNCA

GO Terms for genes affiliated with Dementia

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Cellular components related to Dementia according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1ciliary rootletGO:003525310.0PSEN1, APP
2nuclear outer membraneGO:00056409.9SNCA, PSEN1
3neuromuscular junctionGO:00315949.8APP, PSEN1, ACHE
4growth coneGO:00304269.6PSEN1, SNCA, MAPT
5intracellular membrane-bounded organelleGO:00432319.5CTSB, GRN, ITM2B, VCP, APP
6axonGO:00304249.3APP, PSEN1, ACHE, SNCA, MAPT
7extracellular spaceGO:00056159.0APOE, C9orf72, ACHE, ITM2B, GRN, CTSB
8extracellular vesicular exosomeGO:00700628.8APOE, APP, VCP, CHMP2B, ITM2B, RPS27A
9Golgi apparatusGO:00057948.7ATXN2, APOE, APP, FAM134B, PSEN1, ACHE
10extracellular regionGO:00055768.6APOE, APP, ACHE, ITM2B, SNCA, CTSB
11perinuclear region of cytoplasmGO:00484718.6CTSB, ATXN2, ATN1, APP, VCP, PSEN1

Biological processes related to Dementia according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1axon cargo transportGO:000808810.4MAPT, APP
2smooth endoplasmic reticulum calcium ion homeostasisGO:005156310.3PSEN1, APP
3positive regulation of axon extensionGO:004577310.1APOE, MAPT
4positive regulation of receptor recyclingGO:000192110.1SNCA, PSEN1
5neuron apoptotic processGO:005140210.0ATN1, APP, PSEN1
6regulation of protein bindingGO:004339310.0APP, PSEN1
7positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:00324369.9PSEN1, VCP, NUB1
8response to interferon-gammaGO:00343419.9SNCA, NUB1
9synaptic transmission, cholinergicGO:00072719.9ACHE, APOE
10Notch signaling pathwayGO:00072199.9RPS27A, PSEN1, APP
11negative regulation of neuron apoptotic processGO:00435249.7APOE, PSEN1, SNCA
12regulation of apoptotic processGO:00429819.6CTSB, RPS27A, VCP
13Notch receptor processingGO:00072209.6RPS27A, PSEN1
14cell deathGO:00082198.9TARDBP, GRN, CHMP2B, C9orf72, APOE, ATXN2

Molecular functions related to Dementia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tau protein bindingGO:00481569.9SNCA, APOE
2lipoprotein particle bindingGO:00718139.7MAPT, APOE
3beta-amyloid bindingGO:00015409.7APOE, ACHE, ITM2B
4protein domain specific bindingGO:00199049.3SNCA, CHMP2B, VCP, ATN1
5identical protein bindingGO:00428028.9APOE, APP, VCP, SNCA, TARDBP
6protein bindingGO:00055156.7CTSB, ATXN2, ATN1, NUB1, APOE, APP

Products for genes affiliated with Dementia

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Sources for Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet