MCID: DMN002
MIFTS: 61

Dementia malady

Summaries for Dementia

Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Dementia is the name for a group of symptoms caused by disorders that affect the brain. it is not a specific disease. people with dementia may not be able to think well enough to do normal activities, such as getting dressed or eating. they may lose their ability to solve problems or control their emotions. their personalities may change. they may become agitated or see things that are not there. memory loss is a common symptom of dementia. however, memory loss by itself does not mean you have dementia. people with dementia have serious problems with two or more brain functions, such as memory and language. although dementia is common in very elderly people, it is not part of normal aging. many different diseases can cause dementia, including alzheimer's disease and stroke. drugs are available to treat some of these diseases. while these drugs cannot cure dementia or repair brain damage, they may improve symptoms or slow down the disease. nih: national institute of neurological disorders and stroke

MalaCards: Dementia is related to frontotemporal dementia and vascular dementia. An important gene associated with Dementia is ITM2B (integral membrane protein 2B), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Neuroscience. The drugs citalopram and citalopram hydrobromide and the compounds serine and glutamine have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and nervous system.

Disease Ontology:8 A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.

NINDS:44 Dementia is not a specific disease. It is a descriptive term for a collection of symptoms that can be caused by a number of disorders that affect the brain. People with dementia have significantly impaired intellectual functioning that interferes with normal activities and relationships. They also lose their ability to solve problems and maintain emotional control, and they may experience personality changes and behavioral problems, such as agitation, delusions, and hallucinations. While memory loss is a common symptom of dementia, memory loss by itself does not mean that a person has dementia. Doctors diagnose dementia only if two or more brain functions - such as memory and language skills -- are significantly impaired without loss of consciousness.

Wikipedia:64 Dementia (taken from Latin, originally meaning \"madness\", from de- \"without\" + ment, the root of... more...

Aliases & Classifications for Dementia

Sources:
8Disease Ontology, 44NINDS, 45Novoseek, 34MedlinePlus, 61UMLS, 35MeSH, 27ICD9CM
See all sources

Aliases & Descriptions:

dementia 8 44 45 34 61


External Ids:

Disease Ontology8 DOID:1307
MeSH35 D003704
ICD9CM27 290.8

Related Diseases for Dementia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Dementia family:

dementia with epilepsy, mapt-related

Diseases related to Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 480)
idRelated DiseaseScoreTop Affiliating Genes
1frontotemporal dementia31.8PSEN1, MAPT
2vascular dementia31.7APOE
3alzheimer's disease31.5CTSB, PSEN1, APOE, APP, RPS27A, SNCA
4semantic dementia31.5RPS27A, GRN, MAPT
5lewy body dementia31.3RPS27A, APP, APOE, SNCA, MAPT, ACHE
6amyotrophic lateral sclerosis31.1C9orf72, ATXN2, SNCA, PSEN1, APP, RPS27A
7parkinson's disease31.1RPS27A, APP, APOE, PSEN1, SNCA, ATXN2
8lateral sclerosis31.1SNCA, MAPT
9aphasia30.9MAPT, GRN, C9orf72
10brain disease30.8APP, PSEN1, SNCA, MAPT, SERPINI1
11cadasil30.8APOE, PSEN1, MAPT, SERPINI1
12primary progressive aphasia30.7MAPT, GRN, RPS27A
13dementia familial british30.7SERPINI1, ITM2B, APP
14progressive supranuclear palsy30.7APOE, GRN, MAPT
15cerebral amyloid angiopathy30.7APP, APOE, PSEN1, ITM2B, MAPT
16memory impairment30.7APP, APOE, PSEN1, SNCA, GRN, MAPT
17binswanger's disease30.6APP, APOE, ACHE
18pick's disease30.6PSEN1, MAPT
19tauopathy30.6MAPT, GRN, SNCA, PSEN1, APP, RPS27A
20down syndrome30.5APP, APOE, PSEN1, SNCA, MAPT, ACHE
21apraxia30.3GRN, MAPT
22amyloidosis30.3RPS27A, APP, APOE, PSEN1, CTSB, SNCA
23olivopontocerebellar atrophy30.2SNCA, ATXN2
24alzheimer disease type 230.0APP, APOE, PSEN1, MAPT
25neuroaxonal dystrophy30.0RPS27A, SNCA
26hereditary cerebral amyloid angiopathy30.0APP
27huntington's disease30.0RPS27A, APP, PSEN1, SNCA, ATN1, MAPT
28creutzfeldt-jakob syndrome29.9RPS27A, APP, APOE, SNCA, MAPT
29spinocerebellar ataxia29.9ATXN2
30neuronal intranuclear inclusion disease29.9RPS27A
31striatonigral degeneration29.9RPS27A, SNCA
32frontotemporal lobar degeneration with ubiquitin-positive inclusions29.9GRN
33essential tremor29.9SNCA
34hemorrhage, intracerebral29.8RPS27A, APP, APOE, PSEN1
35amyloid tumor29.6APOE, APP, RPS27A, PSEN1, CTSB, ACHE
36astrocytoma29.6SNCA, CTSB, PSEN1, APP
37brain ischemia29.6APP, CTSB, MAPT
38niemann-pick disease29.6APP, SNCA, MAPT
39dentatorubral-pallidoluysian atrophy29.6ATN1, ATXN2
40pure autonomic failure29.6ACHE, SNCA
41vascular disease10.9
42aids dementia complex10.9
43dementia - subcortical10.7
44cerebral atrophy10.5
45corticobasal degeneration10.5
46amyotrophic lateral sclerosis-parkinsonism/dementia complex10.4
47normal pressure hydrocephalus10.4
48n syndrome10.4
49dementia pugilistica10.4
50inclusion body myopathy with early-onset paget disease and frontotemporal dementia10.4

Graphical network of the top 20 diseases related to Dementia:



Diseases related to dementia

Clinical Features for Dementia

Drugs & Therapeutics for Dementia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Dementia

Drug clinical trials:

Search ClinicalTrials for Dementia

Search NIH Clinical Center for Dementia

Search CenterWatch for Dementia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Dementia

Anatomical Context for Dementia

Animal Models for Dementia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Dementia

Sources:
51PubMed
See all sources

Articles related to Dementia:

(show top 50)    (show all 4250)
idTitleAuthorsYear
1
Can leisure activities slow dementia progression in nursing home residents? A cluster-randomized controlled trial. (24411480)
2014
2
Identification of C9orf72 repeat expansions in patients with amyotrophic lateral sclerosis and frontotemporal dementia in mainland China. (24269022)
2014
3
Frontotemporal dementia in southeast Asia: a comparative study. (23569453)
2013
4
Clinical utility of the functional independence measure for assessment of patients with Alzheimer's disease and vascular dementia. (24289460)
2013
5
Suicidal behavior in dementia: a special risk in semantic dementia. (23821774)
2013
6
The impact of dementia on length of stay in acute hospitals in Ireland. (24339119)
2013
7
Frontotemporal dementia mimicking bipolar disorder. (24241504)
2013
8
Brain expression level and activity of HDAC6 protein in neurodegenerative dementia. (23159615)
2013
9
Should an Elderly Patient with Stage V CKD and Dementia Be Started on Dialysis? (24235287)
2013
10
Re-emergence of artistic traits in a patient with frontotemporal dementia. (22169065)
2012
11
Familial Lund frontotemporal dementia caused by C9ORF72 hexanucleotide expansion. (22483864)
2012
12
A pilot study examining associations between DYRK1A and I+-synuclein dementias. (22269890)
2012
13
The relationship of plasma AI^ levels to dementia in aging individuals with mild cognitive impairment. (21440911)
2011
14
Mild cognitive impairment, degenerative and vascular dementia as predictors of intra-hospital, short- and long-term mortality in the oldest old. (21499020)
2011
15
Central nervous system tuberculosis masquerading as primary dementia: a case report. (22127948)
2011
16
Frontotemporal dementia or frontotemporal lobar degeneration--overview of a group of proteinopathies. (20405665)
2010
17
Hypochondriacal symptoms as the first sign of frontotemporal dementia. (21037134)
2010
18
A computerized technique to assess language use patterns in patients with frontotemporal dementia. (21359164)
2010
19
Pathophysiology of vascular dementia. (19895675)
2009
20
Hand motor activity, cognition, mood, and the rest-activity rhythm in dementia: a clustered RCT. (18926856)
2009
21
Essential tremor is associated with dementia: prospective population-based study in New York. (19704081)
2009
22
Serum copper in Alzheimer's disease and vascular dementia. (23105789)
2008
23
Comparability of the clinical diagnostic criteria for vascular dementia: a critical review. Part I. (18451186)
2008
24
Rivastigmine and Parkinson dementia complex. (17425477)
2007
25
Clusters of cognitive and behavioral disorders clearly distinguish primary progressive aphasia from frontal lobe dementia, and Alzheimer's disease. (17851236)
2007
26
Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies. (16407544)
2006
27
Senile systemic amyloidosis, cerebral amyloid angiopathy, and dementia in a very old Finnish population. (17062383)
2006
28
Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance to vascular dementia and Alzheimer's disease. (16945219)
2006
29
Knowledge of living, nonliving and "sensory quality" categories in semantic dementia. (16251135)
2005
30
Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies. (15210531)
2004
31
Age, apolipoprotein E4, and the risk of HIV dementia: the Hawaii Aging with HIV Cohort. (15579298)
2004
32
Rivastigmine in vascular dementia. (16191241)
2003
33
Subtle cognitive impairment but no dementia in patients with spastin mutations. (12925368)
2003
34
Neurosteroids: Cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics. (14602750)
2003
35
Report on statins and dementia disputed. (11448312)
2001
36
Association between polymorphism in regulatory region of gene encoding tumour necrosis factor alpha and risk of Alzheimer's disease and vascular dementia: a case-control study. (11273064)
2001
37
Distinct behavioural profiles in frontotemporal dementia and semantic dementia. (11181853)
2001
38
A voxel-based morphometry study of semantic dementia: relationship between temporal lobe atrophy and semantic memory. (10632099)
2000
39
Interface between vascular dementia and Alzheimer syndrome. Nosologic redefinition. (10818511)
2000
40
A newly formed amyloidogenic fragment due to a stop codon mutation causes familial British dementia. (10818498)
2000
41
Dopa-resistant parkinsonism, oculomotor disturbances, chorea, mirror movements, dyspraxia, and dementia: the expanding clinical spectrum of hypoparathyroidism. A case report. (11104223)
2000
42
Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates. (9847323)
1999
43
Differential distribution of presenilin-1, Bax, and Bcl-X(L) in Alzheimer's disease and frontotemporal dementia. (10442553)
1999
44
APOE alleles in Alzheimer's disease and vascular dementia in a population aged 85+. (8725898)
1996
45
Striatonigral degeneration combined with olivopontocerebellar atrophy with subcortical dementia and hallucinatory state. (7550604)
1995
46
Evaluation of the AIDS dementia complex in adults. (8115718)
1994
47
5-HT2 receptors, hallucinations, and dementia. (1422634)
1992
48
The clinical significance of cerebral atrophy in dementia. (14591146)
1987
49
Paralytic ileus and dementia in a case of myxoedema. (5368434)
1969
50
PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA. (14107684)
1964

Genetic Variations for Dementia

Expression for genes affiliated with Dementia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dementia

Search GEO for disease gene expression data for Dementia.

Pathways for genes affiliated with Dementia

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN, 53R&D Systems
See all sources

Compounds for genes affiliated with Dementia

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1serine4512.5RPS27A, APP, APOE, PSEN1, CTSB, SNCA
2glutamine4512.4PSEN1, APOE, APP, RPS27A, CTSB, SNCA
3cysteine4512.2RPS27A, APP, APOE, PSEN1, CTSB, SNCA
4glutamate4512.0RPS27A, APP, APOE, PSEN1, CTSB, SNCA
5valine4511.9RPS27A, APP, APOE, PSEN1, CTSB, SNCA
6h2o24511.9RPS27A, APP, APOE, PSEN1, CTSB, SNCA
7arginine4511.8RPS27A, APP, APOE, PSEN1, CTSB, SNCA
8alanine4511.8RPS27A, APP, APOE, PSEN1, CTSB, SNCA
94-hydroxynonenal45 2412.8RPS27A, APP, APOE, PSEN1, SNCA, MAPT
10lactacystin4511.8RPS27A, APP, APOE, PSEN1, SNCA, MAPT
11carbachol45 29 1113.8APP, PSEN1, CTSB, SNCA, MAPT, ACHE
12nmda45 2912.8RPS27A, APP, APOE, PSEN1, MAPT, ACHE
13acetylcholine45 50 29 11 2415.7RPS27A, APP, APOE, SNCA, MAPT, ACHE
14aspartate4511.7RPS27A, APP, APOE, PSEN1, CTSB, MAPT
15testosterone45 60 11 2414.7MAPT, ATN1, SNCA, APOE, APP, RPS27A
16thioflavine s4511.6MAPT, SNCA, APOE, APP, RPS27A
17formate4511.6RPS27A, APP, APOE, SNCA, MAPT
18chloroquine45 2 50 29 1115.6RPS27A, APP, APOE, CTSB, MAPT
19sodium dodecylsulfate4511.6RPS27A, APP, APOE, SNCA, MAPT
20choline45 11 2413.6ACHE, MAPT, SNCA, PSEN1, APP
21actinomycin d4511.5MAPT, CTSB, APOE, APP, RPS27A
22tacrine45 1112.5APP, APOE, MAPT, ACHE
23paraffin4511.5RPS27A, APOE, CTSB, SNCA, MAPT
24donepezil45 11 2413.5ACHE, MAPT, APOE, APP
25galantamine45 50 1113.5ACHE, MAPT, APOE, APP
26atropine45 29 1113.4APP, CTSB, SNCA, ACHE
27guanidine hydrochloride4511.4SNCA, CTSB, APOE, RPS27A
28kainate45 2912.4APOE, PSEN1, CTSB, MAPT
29biotin45 11 2413.4CTSB, PSEN1, APOE, RPS27A
30threonine4511.3RPS27A, PSEN1, CTSB, TRPM7, MAPT, VCP
31folate4511.3APP, APOE, PSEN1, MAPT
32thioflavin4511.3APP, SNCA, MAPT
33nicotine45 50 29 1114.3ACHE, MAPT, APOE, APP
34metrifonate4511.3APP, APOE, ACHE
35thapsigargin45 6012.3APP, PSEN1, CTSB, VCP
36thioflavin t4511.3APP, APOE, SNCA
37memantine45 29 1113.3APP, MAPT, ACHE
38dopamine45 29 11 2414.3SNCA, APP, RPS27A
39hydrogen45 2412.2SNCA, CTSB, PSEN1, RPS27A
40spec-t4511.2APOE, PSEN1, MAPT
41creatinine4511.2MAPT, CTSB, APOE, APP, RPS27A
42cyclosporin a45 29 6013.1CTSB, APP, RPS27A
43phenserine45 6012.1APP, ACHE
446-hydroxydopamine4511.1RPS27A, APP, SNCA
45huperzine a4511.0APP, ACHE
46rivastigmine45 1112.0APOE, ACHE
47ddvp4510.9ACHE, APP
48tmao4510.8MAPT, SNCA
4924s-hydroxy-cholesterol4510.7APP, APOE
50ginkgo4510.5APP, ACHE

GO Terms for genes affiliated with Dementia

Sources:
16Gene Ontology
See all sources

Cellular components related to Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:00579411.8ACHE, APP, APOE, FAM134B, PSEN1, SNCA
2perinuclear region of cytoplasmGO:04847111.6APP, PSEN1, CTSB, SNCA, ATXN2, ATN1
3axonGO:03042411.3APP, PSEN1, SNCA, MAPT, ACHE
4intracellular membrane-bounded organelleGO:04323111.3APP, CTSB, ITM2B, GRN, VCP
5extracellular spaceGO:00561511.2APOE, CTSB, ITM2B, GRN, ACHE, SERPINI1
6neuromuscular junctionGO:03159410.9ACHE, PSEN1, APP
7growth coneGO:03042610.9MAPT, SNCA, PSEN1
8ciliary rootletGO:03525310.5PSEN1, APP

Biological processes related to Dementia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cell deathGO:00821911.6TRPM7, GRN, CHMP2B, C9orf72, ATXN2, APOE
2neuron apoptotic processGO:05140211.1ATN1, PSEN1, APP
3positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243611.1VCP, NUB1, PSEN1
4smooth endoplasmic reticulum calcium ion homeostasisGO:05156311.0APP, PSEN1
5negative regulation of neuron apoptotic processGO:04352410.9SNCA, PSEN1, APOE
6positive regulation of receptor recyclingGO:00192110.9PSEN1, SNCA
7axon cargo transportGO:00808810.8MAPT, APP
8positive regulation of axon extensionGO:04577310.8MAPT, APOE
9synaptic transmission, cholinergicGO:00727110.7APOE, ACHE
10Notch signaling pathwayGO:00721910.6PSEN1, APP, RPS27A

Molecular functions related to Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.0APP, APOE, PSEN1, CTSB, SNCA, ITM2B
2protein domain specific bindingGO:01990411.1VCP, CHMP2B, ATN1, SNCA
3beta-amyloid bindingGO:00154011.0ACHE, ITM2B, APOE
4tau protein bindingGO:04815610.8SNCA, APOE
5lipoprotein particle bindingGO:07181310.7APOE, MAPT

Products for genes affiliated with Dementia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dementia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet