MCID: DMN002
MIFTS: 65

Dementia malady

Mental diseases category

Summaries for Dementia

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MedlinePlus:34 Dementia is the name for a group of symptoms caused by disorders that affect the brain. it is not a specific disease. people with dementia may not be able to think well enough to do normal activities, such as getting dressed or eating. they may lose their ability to solve problems or control their emotions. their personalities may change. they may become agitated or see things that are not there. memory loss is a common symptom of dementia. however, memory loss by itself does not mean you have dementia. people with dementia have serious problems with two or more brain functions, such as memory and language. although dementia is common in very elderly people, it is not part of normal aging. many different diseases can cause dementia, including alzheimer's disease and stroke. drugs are available to treat some of these diseases. while these drugs cannot cure dementia or repair brain damage, they may improve symptoms or slow down the disease. nih: national institute of neurological disorders and stroke

MalaCards based summary: Dementia is related to vascular dementia and semantic dementia. An important gene associated with Dementia is MAPT (microtubule-associated protein tau), and among its related pathways are Fanconi anemia pathway and Reelin Pathway (Cajal-Retzius cells). The drugs citalopram and citalopram hydrobromide and the compounds thioflavin and phenserine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related mouse phenotypes are other and taste/olfaction.

Disease Ontology:10 A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.

NINDS:44 Dementia is not a specific disease. It is a descriptive term for a collection of symptoms that can be caused by a number of disorders that affect the brain. People with dementia have significantly impaired intellectual functioning that interferes with normal activities and relationships. They also lose their ability to solve problems and maintain emotional control, and they may experience personality changes and behavioral problems, such as agitation, delusions, and hallucinations. While memory loss is a common symptom of dementia, memory loss by itself does not mean that a person has dementia. Doctors diagnose dementia only if two or more brain functions - such as memory and language skills -- are significantly impaired without loss of consciousness.

Wikipedia:65 Dementia is a broad category of brain diseases that cause a long term and often gradual decrease in the... more...

Aliases & Classifications for Dementia

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Sources:
10Disease Ontology, 44NINDS, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 29ICD9CM
See all sources

Dementia, Aliases & Descriptions:

Name: Dementia 10 44 45 34 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology10 DOID:1307
MeSH35 D003704
ICD9CM29 290.8

Related Diseases for Dementia

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Diseases related to Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 545)
idRelated DiseaseScoreTop Affiliating Genes
1vascular dementia31.9APOE
2semantic dementia31.6GRN, MAPT, RPS27A
3lateral sclerosis31.2SNCA, MAPT
4alzheimer disease31.0APP, APOE, VCP, PSEN1, ACHE, ITM2B
5aphasia31.0TARDBP, GRN, MAPT, C9orf72
6dementia, frontotemporal31.0PSEN1, MAPT
7motor neuron disease31.0VCP, SNCA, RPS27A, MAPT, GRN, TARDBP
8cerebral amyloid angiopathy30.8APOE, APP, PSEN1, ITM2B, MAPT
9dementia, lewy body30.8MAPT, SNCA, APOE
10cerebrovascular disease30.8ACHE, APP, APOE
11binswanger's disease30.7ACHE, APP, APOE
12myopathy30.7RPS27A, ACHE, VCP, APP
13tauopathy30.7APP, PSEN1, SNCA, RPS27A, MAPT, GRN
14rem sleep behavior disorder30.7SNCA
15multiple system atrophy30.7SNCA, RPS27A, MAPT
16down syndrome30.6APOE, APP, PSEN1, ACHE, SNCA, MAPT
17schizophrenia30.6SNCA, ACHE, PSEN1, ATN1
18pick disease30.6PSEN1, MAPT
19frontotemporal lobar degeneration with ubiquitin-positive inclusions30.5RPS27A, MAPT, GRN
20apraxia30.5MAPT, GRN
21dementia, familial british30.4APP, ITM2B
22prion disease30.4APP, PSEN1, MAPT
23creutzfeldt-jakob disease30.4APOE, APP, SNCA, RPS27A, MAPT
24olivopontocerebellar atrophy30.3ATXN2, SNCA
25amyloidosis30.3CTSB, MAPT, RPS27A, SNCA, ITM2B, PSEN1
26amyotrophic lateral sclerosis 130.2VCP, CHMP2B, PSEN1, SNCA, RPS27A, MAPT
27brain disease30.2MAPT, SNCA, PSEN1, APP
28neuroaxonal dystrophy30.2SNCA, RPS27A
29huntington disease30.1ATN1, APP, PSEN1, ACHE, SNCA, RPS27A
30supranuclear palsy, progressive30.1APOE, MAPT, GRN, TARDBP
31spinocerebellar ataxia30.0ATXN2, ATN1, SNCA, RPS27A, MAPT
32hereditary cerebral amyloid angiopathy30.0APP
33dentatorubro-pallidoluysian atrophy29.9ATXN2, ATN1
34brain ischemia29.9APP, MAPT, CTSB
35striatonigral degeneration29.9SNCA, RPS27A
36alzheimer disease-229.9APOE, APP, PSEN1, MAPT
37parkinson disease, late-onset29.9MAPT, RPS27A, SNCA, APOE
38machado-joseph disease29.9ATXN2, ATN1, VCP, SNCA, RPS27A
39neuronal intranuclear inclusion disease29.7RPS27A
40spinocerebellar ataxia 729.7ATXN2
41niemann-pick disease, type c129.7MAPT, SNCA, APP
42spinocerebellar ataxia 1229.7ATN1, ATXN2
43spinocerebellar ataxia 1729.7ATN1, ATXN2
44pure autonomic failure29.7SNCA, ACHE
45astrocytoma29.7APP, PSEN1, SNCA, CTSB
46aids dementia complex10.9
47cerebritis10.8
48neuronitis10.8
49cadasil10.6
50hiv-110.6

Graphical network of the top 20 diseases related to Dementia:



Diseases related to dementia

Symptoms for Dementia

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Drugs & Therapeutics for Dementia

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Drug clinical trials:

Search ClinicalTrials for Dementia

Search NIH Clinical Center for Dementia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Dementia

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Anatomical Context for Dementia

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MalaCards organs/tissues related to Dementia:

33
Brain, Cortex, Testes, Bone, Temporal lobe, Heart, Monocytes, Eye, Skin, T cells, Endothelial, Prefrontal cortex, Spinal cord, Thalamus, Amygdala, Cerebellum, B cells, Hypothalamus, Caudate nucleus, Spleen, Kidney, Liver, Thyroid, Parietal lobe, Pituitary

Animal Models for Dementia or affiliated genes

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Publications for Dementia

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Articles related to Dementia:

(show top 50)    (show all 4461)
idTitleAuthorsYear
1
An Exploratory Study of Grief and Health-Related Quality of Life for Caregivers of People With Dementia. (24381138)
2013
2
Posttraumatic stress disorder exacerbation with cholinesterase inhibitor in a patient with dementia. (24307975)
2013
3
Immunological Aspects and Anti-Amyloid Strategy for Alzheimer's Dementia / IMUNOLOA KI ASPEKTI I ANTIAMILOIDNE STRATEGIJE ZA ALZHEIMEROVU DEMENCIJU. (24384767)
2013
4
Attachment and coping of dementia care staff: The role of staff attachment style, geriatric nursing self-efficacy, and approaches to dementia in burnout. (24339071)
2013
5
Dementia Care in Nursing Barker Sue Board Michele Dementia Care in Nursing 184pp AL18.99 Sage 9780857258014 085725801X [Formula: see text]. (24283316)
2013
6
Evaluation of an education intervention to implement a capability model of dementia care. (24339075)
2013
7
The contribution of twins to the study of cognitive ageing and dementia: The Older Australian Twins Study. (24423226)
2013
8
The effectiveness of dyadic interventions for people with dementia and their caregivers. (24337642)
2013
9
Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia. (22335970)
2012
10
Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies. (22226802)
2012
11
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. (22406228)
2012
12
I+-Synuclein mRNA and soluble I+-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease. (22560502)
2012
13
Phenotypic signatures of genetic frontotemporal dementia. (21986680)
2011
14
Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin. (21185921)
2011
15
Reverse concreteness effects are not a typical feature of semantic dementia: evidence for the hub-and-spoke model of conceptual representation. (21285258)
2011
16
Genetic evidence that vascular dementia is related to Alzheimer's disease: genetic association between tau polymorphism and vascular dementia in the Chinese population. (21044986)
2011
17
Clinical profiles of late-onset semantic dementia, compared with early-onset semantic dementia and late-onset Alzheimer's disease. (21447109)
2011
18
Clinical staging and disease progression in frontotemporal dementia. (20479357)
2010
19
Frontotemporal dementia phenotype associated with MAPT gene duplication. (20634582)
2010
20
Interleukin-1 beta (C-511T) genetic polymorphism is associated with cognitive performance in elderly males without dementia. (19013689)
2010
21
Inclusion body myopathy and frontotemporal dementia caused by a novel VCP mutation. (17889967)
2009
22
Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. (19073835)
2009
23
No association of common VCP variants with sporadic frontotemporal dementia. (17618707)
2009
24
Minimally invasive surgical approach for three-vessel occlusion as a model of vascular dementia in the rat-brain bioenergetics assay. (19272617)
2009
25
Expert opinion on the management of behavioural and psychological symptoms of dementia (BPSD) and investigation into prescribing practices in the UK. (19156700)
2009
26
Small vessel versus large vessel vascular dementia: risk factors and MRI findings. (18677637)
2008
27
Communication impairment in the AIDS dementia complex (ADC): a case report. (18242630)
2008
28
Defining "prodromal" Alzheimer's disease, frontotemporal dementia, and Lewy body dementia: are we there yet? (18327642)
2008
29
Nitrosative stress with HIV dementia causes decreased L-prostaglandin D synthase activity. (18077799)
2008
30
Statins and dementia. (17877925)
2007
31
Efficacy study of galantamine in possible Alzheimer's disease with or without cerebrovascular disease and vascular dementia in Thai patients: a slow-titration regimen. (16700849)
2006
32
Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer's type in an elderly Arab population in Wadi Ara, Israel. (18568123)
2005
33
Jargon dyslexia in an individual with semantic dementia: further evidence for task-specificity in phonological output. (16251136)
2005
34
Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease: a comparison. (15136683)
2004
35
A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. (14746899)
2004
36
The contribution of autobiographical significance to semantic memory: evidence from Alzheimer's disease, semantic dementia, and amnesia. (14615074)
2004
37
The role of viruses and of APOE in dementia. (15246985)
2004
38
Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. (12364720)
2002
39
Hyperphosphorylated tau deposition parallels prion protein burden in a case of Gerstmann-StrAoussler-Scheinker syndrome P102L mutation complicated with dementia. (12200619)
2002
40
Hypersensitive mousetraps, alpha1-antitrypsin deficiency and dementia. (12023831)
2002
41
Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia--an epidemiological study using the polymerase chain reaction (PCR) method. (10860300)
2000
42
Search for a mutation in the tau gene in a Swiss family with frontotemporal dementia. (10683298)
2000
43
A stop-codon mutation in the BRI gene associated with familial British dementia. (10391242)
1999
44
Motor neuron disease-inclusion dementia presenting as cortical-basal ganglionic degeneration. (10435507)
1999
45
Vasodilator responses to acetazolamide tested in subtypes of vascular dementia. (17895108)
1998
46
Dementia pugilistica and cavum septi pellucidi: born to box? (9421861)
1997
47
Diagnosing Alzheimer's disease in very elderly patients. Relevance of some functional and psychobehavioral aspects assessed by the Gottfries-BrAYne-Steen Rating Scale for Dementia. Study Group on Brain Aging, Italian Society of Gerontology and Geriatrics. (9386985)
1997
48
Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins. (7717459)
1995
49
Review of antiretroviral therapy in the prevention of HIV-related AIDS dementia complex (ADC). (7614899)
1995
50
Spinal cord neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex: an immunohistochemical study. (2161095)
1990

Variations for Dementia

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Expression for genes affiliated with Dementia

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Search GEO for disease gene expression data for Dementia.

Pathways for genes affiliated with Dementia

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Pathways related to Dementia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0RPS27A, VCP
29.9MAPT, APP, APOE
39.8CTSB, PSEN1, APP
49.6APOE, APP, PSEN1, MAPT
5
Show member pathways
Alzheimers Disease38
9.0MAPT, SNCA, MT-ATP6, PSEN1, APP, APOE
68.9APOE, APP, CHMP2B, ITM2B, SNCA, RPS27A
78.8APOE, APP, PSEN1, SNCA, MAPT, TARDBP

Compounds for genes affiliated with Dementia

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Compounds related to Dementia according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1thioflavin4510.2APP, SNCA, MAPT
2phenserine45 6111.2ACHE, APP
3memantine45 30 51 1313.1APP, ACHE, MAPT
4thioflavin t4510.1SNCA, APP, APOE
5metrifonate4510.0APOE, APP, ACHE
6spec-t4510.0MAPT, PSEN1, APOE
7tmao4510.0MAPT, SNCA
8huperzine a459.9ACHE, APP
9tacrine45 1310.9MAPT, ACHE, APP, APOE
10donepezil45 51 26 1312.9APOE, APP, ACHE, MAPT
11galantamine45 51 1311.9MAPT, ACHE, APP, APOE
12rivastigmine45 1310.9ACHE, APOE
136-hydroxydopamine459.9RPS27A, SNCA, APP
14kainate45 3010.8CTSB, MAPT, PSEN1, APOE
15folate459.8APOE, APP, PSEN1, MAPT
16chloroquine45 3 51 30 1313.8APOE, APP, RPS27A, MAPT, CTSB
17atropine45 30 1311.7APP, ACHE, SNCA, CTSB
18guanidine hydrochloride459.7APOE, SNCA, RPS27A, CTSB
19thioflavine s459.7MAPT, RPS27A, SNCA, APP, APOE
20biotin45 26 1311.7APOE, PSEN1, RPS27A, CTSB
21formate459.7APOE, APP, SNCA, RPS27A, MAPT
22thapsigargin45 6110.7CTSB, PSEN1, VCP, APP
23nicotine45 30 51 1312.7APOE, APP, ACHE, MAPT
24sodium dodecylsulfate459.7APOE, APP, SNCA, RPS27A, MAPT
25actinomycin d459.7APOE, APP, RPS27A, MAPT, CTSB
26cyclosporin a45 30 6111.6APOE, APP, RPS27A, MAPT, CTSB
27ddvp459.6ACHE, APP
28choline45 26 1311.5APP, PSEN1, ACHE, SNCA, MAPT
29creatinine459.5APOE, APP, RPS27A, MAPT, CTSB
30paraffin459.5APOE, SNCA, RPS27A, MAPT, CTSB
314-hydroxynonenal45 2610.4APOE, APP, PSEN1, SNCA, RPS27A, MAPT
32lactacystin459.4APOE, APP, PSEN1, SNCA, RPS27A, MAPT
33heparin45 30 26 1312.4APOE, APP, SNCA, MAPT, CTSB
34aspartate459.4APOE, APP, PSEN1, RPS27A, MAPT, CTSB
35hydrogen45 2610.4PSEN1, MT-ATP6, SNCA, RPS27A, CTSB
36testosterone45 61 26 1312.4ATN1, APOE, APP, SNCA, RPS27A, MAPT
37carbachol45 30 1311.3APP, PSEN1, ACHE, SNCA, MAPT, CTSB
38threonine459.3VCP, PSEN1, RPS27A, MAPT, CTSB, TRPM7
39acetylcholine45 51 30 26 1313.3APOE, APP, ACHE, SNCA, RPS27A, MAPT
40dopamine45 30 26 1312.3APOE, APP, ACHE, SNCA, RPS27A, MAPT
41valine459.2APOE, APP, PSEN1, SNCA, RPS27A, MAPT
42h2o2459.1APOE, APP, PSEN1, SNCA, RPS27A, MAPT
43cycloheximide459.1APOE, PSEN1, RPS27A, MAPT, CTSB
44nmda45 3010.1APOE, APP, PSEN1, ACHE, RPS27A, MAPT
45arginine459.1APOE, APP, PSEN1, SNCA, RPS27A, MAPT
46alanine459.1APOE, APP, PSEN1, SNCA, RPS27A, MAPT
47glutamate458.8APOE, APP, PSEN1, ACHE, SNCA, RPS27A
48cysteine458.6ATN1, APOE, APP, PSEN1, SNCA, RPS27A
49glutamine458.5APP, APOE, ATN1, ATXN2, VCP, PSEN1
50serine458.3APOE, APP, VCP, PSEN1, ACHE, SNCA

GO Terms for genes affiliated with Dementia

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Cellular components related to Dementia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1ciliary rootletGO:003525310.0PSEN1, APP
2nuclear outer membraneGO:00056409.9SNCA, PSEN1
3neuromuscular junctionGO:00315949.8APP, PSEN1, ACHE
4growth coneGO:00304269.6PSEN1, SNCA, MAPT
5intracellular membrane-bounded organelleGO:00432319.5CTSB, GRN, ITM2B, VCP, APP
6axonGO:00304249.3APP, PSEN1, ACHE, SNCA, MAPT
7extracellular spaceGO:00056159.0APOE, C9orf72, ACHE, ITM2B, GRN, CTSB
8extracellular vesicular exosomeGO:00700628.8APOE, APP, VCP, CHMP2B, ITM2B, RPS27A
9Golgi apparatusGO:00057948.7ATXN2, APOE, APP, FAM134B, PSEN1, ACHE
10extracellular regionGO:00055768.6APOE, APP, ACHE, ITM2B, SNCA, CTSB
11perinuclear region of cytoplasmGO:00484718.6CTSB, ATXN2, ATN1, APP, VCP, PSEN1

Biological processes related to Dementia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1axon cargo transportGO:000808810.4MAPT, APP
2smooth endoplasmic reticulum calcium ion homeostasisGO:005156310.3PSEN1, APP
3positive regulation of axon extensionGO:004577310.1APOE, MAPT
4positive regulation of receptor recyclingGO:000192110.1SNCA, PSEN1
5neuron apoptotic processGO:005140210.0ATN1, APP, PSEN1
6regulation of protein bindingGO:004339310.0APP, PSEN1
7positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:00324369.9PSEN1, VCP, NUB1
8response to interferon-gammaGO:00343419.9SNCA, NUB1
9synaptic transmission, cholinergicGO:00072719.9ACHE, APOE
10Notch signaling pathwayGO:00072199.9RPS27A, PSEN1, APP
11negative regulation of neuron apoptotic processGO:00435249.7APOE, PSEN1, SNCA
12regulation of apoptotic processGO:00429819.6CTSB, RPS27A, VCP
13Notch receptor processingGO:00072209.6RPS27A, PSEN1
14cell deathGO:00082198.9TARDBP, GRN, CHMP2B, C9orf72, APOE, ATXN2

Molecular functions related to Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tau protein bindingGO:00481569.9SNCA, APOE
2lipoprotein particle bindingGO:00718139.7MAPT, APOE
3beta-amyloid bindingGO:00015409.7APOE, ACHE, ITM2B
4protein domain specific bindingGO:00199049.3SNCA, CHMP2B, VCP, ATN1
5identical protein bindingGO:00428028.9APOE, APP, VCP, SNCA, TARDBP
6protein bindingGO:00055156.7CTSB, ATXN2, ATN1, NUB1, APOE, APP

Products for genes affiliated with Dementia

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Sources for Dementia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet