FDD
MCID: DMN004
MIFTS: 17

Dementia, Familial Danish (FDD) malady

Neuronal, Ear, Genetic categories

Summaries for Dementia, Familial Danish

Sources:
47OMIM, 33MalaCards
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MalaCards: Dementia, Familial Danish, also known as cerebellar ataxia, cataract, deafness, and dementia or psychosis, is related to amyloidosis and amyloidosis cerebral. An important gene associated with Dementia, Familial Danish is ITM2B (integral membrane protein 2B).

Description from OMIM:47 117300

Aliases & Classifications for Dementia, Familial Danish

Sources:
43NIH Rare Diseases, 47OMIM, 45Novoseek, 61UMLS, 49Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Neuronal, Ear


Aliases & Descriptions:

dementia, familial danish 43 47 45 61
cerebellar ataxia, cataract, deafness, and dementia or psychosis 43
heredopathia ophthalmootoencephalica 43
familial dementia, danish type 49
familial danish dementia 43
hooe 43
fdd 43


External Ids:

OMIM47 117300
MESH via Orphanet36 C538209
ICD10 via Orphanet26 G31.0
UMLS via Orphanet62 C1861735

Related Diseases for Dementia, Familial Danish

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dementia, Familial Danish via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis10.2
2amyloidosis cerebral10.2

Clinical Features for Dementia, Familial Danish

Sources:
47OMIM
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Clinical features from OMIM:

117300

Clinical synopsis from OMIM:

117300

Drugs & Therapeutics for Dementia, Familial Danish

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Dementia, Familial Danish

Drug clinical trials:

Search ClinicalTrials for Dementia, Familial Danish

Search NIH Clinical Center for Dementia, Familial Danish

Search CenterWatch for Dementia, Familial Danish

Genetic Tests for Dementia, Familial Danish

Anatomical Context for Dementia, Familial Danish

Animal Models for Dementia, Familial Danish or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Dementia, Familial Danish

Sources:
51PubMed
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Articles related to Dementia, Familial Danish:

idTitleAuthorsYear
1
Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia. (24405716)
2014
2
Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias. (23261769)
2013
3
Increased AI^PP processing in familial Danish dementia patients. (21841249)
2011
4
Modeling familial British and Danish dementia. (19779737)
2010
5
Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease. (17374542)
2007
6
Genetic alterations of the BRI2 gene: familial British and Danish dementias. (16612984)
2006
7
Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques. (16091362)
2005
8
Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia. (15913558)
2005
9
Oligomerization and neurotoxicity of the amyloid ADan peptide implicated in familial Danish dementia. (14690516)
2004
10
Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta. (11895040)
2002

Genetic Variations for Dementia, Familial Danish

Expression for genes affiliated with Dementia, Familial Danish

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dementia, Familial Danish

Search GEO for disease gene expression data for Dementia, Familial Danish.

Pathways for genes affiliated with Dementia, Familial Danish

Compounds for genes affiliated with Dementia, Familial Danish

GO Terms for genes affiliated with Dementia, Familial Danish

Products for genes affiliated with Dementia, Familial Danish

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dementia, Familial Danish

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet