MCID: DMN031
MIFTS: 37

Dementia, Lewy Body malady

Genetic diseases, Rare diseases, Mental diseases categories

Aliases & Classifications for Dementia, Lewy Body

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Dementia, Lewy Body, Aliases & Descriptions:

Name: Dementia, Lewy Body 45 10
Lewy Body Dementia 45 9 41 42 11
Lewy Body Disease 9 41 43 32 60
Dementia with Lewy Bodies 9 42 22
 
Autosomal Dominant Diffuse Lewy Body Disease 41 60
Diffuse Lewy Body Disease 9 41
Senile Dementia of the Lewy Body Type 9
Dlb 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases


External Ids:

OMIM45 127750
Disease Ontology9 DOID:12217
ICD9CM27 331.82
MeSH33 D020961
NCIt38 C84826

Summaries for Dementia, Lewy Body

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MedlinePlus:32 Lewy body disease is one of the most common causes of dementia in the elderly. dementia is the loss of mental functions severe enough to affect normal activities and relationships. lewy body disease happens when abnormal structures, called lewy bodies, build up in areas of the brain. the disease may cause a wide range of symptoms, including changes in alertness and attention hallucinations problems with movement and posture muscle stiffness confusion loss of memory lewy body disease can be hard to diagnose, because parkinson's disease and alzheimer's disease cause similar symptoms. scientists think that lewy body disease might be related to these diseases, or that they sometimes happen together. lewy body disease usually begins between the ages of 50 and 85. the disease gets worse over time. there is no cure. treatment focuses on drugs to help symptoms. nih: national institute of neurological disorders and stroke

MalaCards based summary: Dementia, Lewy Body, also known as lewy body dementia, is related to multiple system atrophy and dementia, and has symptoms including autosomal dominant inheritance, dementia and delusions. An important gene associated with Dementia, Lewy Body is SNCA (synuclein, alpha (non A4 component of amyloid precursor)), and among its related pathways is Neuroscience. The compounds polysaccharide and hydrogen have been mentioned in the context of this disorder. Affiliated tissues include brain.

Disease Ontology:9 A dementia and a synucleinopathy that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called lewy bodies, throughout the brain that results in progressive decline in mental abilities.

NIH Rare Diseases:41 Lewy bodies dementia is one of the most common types of dementia. the central feature of this condition is progressive cognitive decline, combined with three additional defining features: (1) fluctuations in alertness and attention, such as frequent drowsiness, lethargy, lengthy periods of time spent staring into space, or disorganized speech; (2) recurrent visual hallucinations, and (3) parkinsonian motor symptoms, such as rigidity and the loss of spontaneous movement. although the exact cause of this condition is unknown, symptoms result from the build-up of abnormal structures, called lewy bodies, inside the brain. this condition usually occurs sporadically, in people with no known family history of the disease. however, rare familial cases have been reported. last updated: 1/12/2012

OMIM:45 Dementia with Lewy bodies (DLB) is a neurodegenerative disorder clinically characterized by dementia and parkinsonism,... (127750) more...

NINDS:42 Is one of the most common types of progressive dementia. The central features of DLB include progressive cognitive decline, ?fluctuations? in alertness and attention, visual hallucinations, and parkinsonian motor symptoms, such as slowness of movement, difficulty walking, or rigidity.

Wikipedia:63 Dementia with Lewy bodies (DLB), also known under a variety of other names including Lewy body dementia... more...

Related Diseases for Dementia, Lewy Body

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Graphical network of the top 20 diseases related to Dementia, Lewy Body:



Diseases related to dementia, lewy body

Symptoms for Dementia, Lewy Body

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Symptoms by clinical synopsis from OMIM:

127750

Clinical features from OMIM:

127750

HPO human phenotypes related to Dementia, Lewy Body:

(show all 6)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 dementia HP:0000726
3 delusions HP:0000746
4 parkinsonism HP:0001300
5 visual hallucinations HP:0002367
6 fluctuations in consciousness HP:0007159

Drugs & Therapeutics for Dementia, Lewy Body

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Drug clinical trials:

Search ClinicalTrials for Dementia, Lewy Body

Search NIH Clinical Center for Dementia, Lewy Body

Genetic Tests for Dementia, Lewy Body

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Genetic tests related to Dementia, Lewy Body:

id Genetic test Affiliating Genes
1 Lewy Body Dementia22

Anatomical Context for Dementia, Lewy Body

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MalaCards organs/tissues related to Dementia, Lewy Body:

31
Brain

Animal Models for Dementia, Lewy Body or affiliated genes

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Publications for Dementia, Lewy Body

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Articles related to Dementia, Lewy Body:

idTitleAuthorsYear
1
Cognitive fluctuations in connection to dysgraphia: a comparison of Alzheimer's disease with dementia Lewy bodies. (25848239)
2015

Variations for Dementia, Lewy Body

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UniProtKB/Swiss-Prot genetic disease variations for Dementia, Lewy Body:

62
id Symbol AA change Variation ID SNP ID
1SNCAp.Glu46LysVAR_022703

Clinvar genetic disease variations for Dementia, Lewy Body:

6
id Gene Variation Type Significance SNP ID Assembly Location
1SNCANM_000345.3(SNCA): c.136G> A (p.Glu46Lys)single nucleotide variantPathogenicrs104893875GRCh37Chr 4, 90749321: 90749321
2SNCASNCA, DUPLICATIONduplicationPathogenic
3GBANM_001005741.2(GBA): c.1448T> C (p.Leu483Pro)single nucleotide variantPathogenic, risk factorrs421016GRCh37Chr 1, 155205043: 155205043
4GBANM_001005741.2(GBA): c.1448T> C (p.Leu483Pro)single nucleotide variantPathogenic, risk factorrs421016GRCh37Chr 1, 155205043: 155205043
5SNCBNM_001001502.1(SNCB): c.208G> A (p.Val70Met)single nucleotide variantPathogenicrs104893936GRCh37Chr 5, 176053473: 176053473
6SNCBNM_001001502.1(SNCB): c.368C> A (p.Pro123His)single nucleotide variantPathogenicrs104893937GRCh37Chr 5, 176048219: 176048219

Expression for genes affiliated with Dementia, Lewy Body

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Search GEO for disease gene expression data for Dementia, Lewy Body.

Pathways for genes affiliated with Dementia, Lewy Body

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Pathways related to Dementia, Lewy Body according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SNCB, SNCA

Compounds for genes affiliated with Dementia, Lewy Body

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Sources:
43Novoseek, 24HMDB
See all sources

Compounds related to Dementia, Lewy Body according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1polysaccharide439.4SNCA, GBA
2hydrogen43 2410.4SNCA, GBA
3phospholipid439.3GBA, SNCA
4iron43 2410.0SNCB, SNCA
5lipid438.9SNCB, SNCA, GBA

GO Terms for genes affiliated with Dementia, Lewy Body

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Cellular components related to Dementia, Lewy Body according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth coneGO:00304269.3SNCB, SNCA
2terminal boutonGO:00431959.0SNCB, SNCA

Biological processes related to Dementia, Lewy Body according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:00435249.3SNCB, SNCA
2synapse organizationGO:00508089.0SNCB, SNCA

Molecular functions related to Dementia, Lewy Body according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-tubulin bindingGO:00484879.3SNCB, SNCA
2alpha-tubulin bindingGO:00430149.0SNCB, SNCA

Products for genes affiliated with Dementia, Lewy Body

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Dementia, Lewy Body

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet