MCID: DMY001
MIFTS: 45

Demyelinating Polyneuropathy malady

Summaries for Demyelinating Polyneuropathy

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33MalaCards
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MalaCards: Demyelinating Polyneuropathy, also known as peripheral demyelinating neuropathy, is related to diabetic polyneuropathy and hepatitis d. An important gene associated with Demyelinating Polyneuropathy is AIF1 (allograft inflammatory factor 1), and among its related pathways are Axonal growth inhibition (RHOA activation) and Hematopoietic cell lineage. The compounds cycloheximide and pegasys have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Classifications for Demyelinating Polyneuropathy

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 40NCIt
See all sources

Aliases & Descriptions:

demyelinating polyneuropathy 8 10
peripheral demyelinating neuropathy 8 61


External Ids:

Disease Ontology8 DOID:5214
SNOMED-CT57 23414001
NCIt40 C27062

Related Diseases for Demyelinating Polyneuropathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the chronic inflammatory demyelinating polyneuropathy family:

demyelinating polyneuropathy subacute inflammatory demyelinating polyneuropathy

Diseases related to Demyelinating Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic polyneuropathy30.7NGF
2hepatitis d30.7IFNA1, IFNA2
3hepatitis c30.7TNF, CTLA4, IFNA2, CD28, IFNA1
4systemic lupus erythematosus30.4FCGR2B, IFNA1, TNF, CTLA4, CD28
5arthritis30.3FCGR2B, CTLA4, CSF1, TNF, CXCL9
6amyotrophic lateral sclerosis30.3CSF1, NGF, MAG, GDNF, CNTF
7alopecia30.1AIRE
8macroglobulinemia30.1MAG
9thyroiditis30.1CTLA4, IFNA1
10graft versus host disease30.1TNF, CTLA4, CD28
11thrombocytopenia30.1IFNA2, IFNA1, CSF1, FCGR2B
12chronic inflammatory demyelinating polyneuropathy11.4
13guillain-barr� syndrome10.8
14neuropathy, inflammatory demyelinating10.7
15n syndrome10.5
16subacute inflammatory demyelinating polyneuropathy10.5
17peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease10.5
18poems syndrome10.4
19hepatitis a10.4
20multifocal motor neuropathy10.4
21cytomegalovirus infection10.4
22tooth disease10.3
23chronic pain10.3
24hepatitis c virus10.3
25pcwh syndrome10.3
26eosinophilia-myalgia syndrome10.2
27mononeuritis multiplex10.2
28lateral sclerosis10.2
29carpal tunnel syndrome10.2
30tuberculosis10.2
31amyloid neuropathy10.2
32progressive multifocal leukoencephalopathy10.2
33marfan syndrome10.1
34axonal neuropathy10.1
35membranous glomerulonephritis10.1
36focal segmental glomerulosclerosis10.1
37pulmonary tuberculosis10.1
38evans' syndrome10.1
39granulomatous dermatitis10.1
40hepatitis e10.1
41mixed connective tissue disease10.1
42primary biliary cirrhosis10.1
43hypoparathyroidism10.1
44restless legs syndrome10.1
45common variable immunodeficiency10.1
46internuclear ophthalmoplegia10.1
47hemochromatosis10.1
48spinal stenosis10.1
49plasmodium vivax malaria10.1
50hereditary spastic paraplegia10.1

Graphical network of the top 20 diseases related to Demyelinating Polyneuropathy:



Diseases related to demyelinating polyneuropathy

Clinical Features for Demyelinating Polyneuropathy

Drugs & Therapeutics for Demyelinating Polyneuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Demyelinating Polyneuropathy

Drug clinical trials:

Search ClinicalTrials for Demyelinating Polyneuropathy

Search NIH Clinical Center for Demyelinating Polyneuropathy

Search CenterWatch for Demyelinating Polyneuropathy

Genetic Tests for Demyelinating Polyneuropathy

Anatomical Context for Demyelinating Polyneuropathy

Animal Models for Demyelinating Polyneuropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Demyelinating Polyneuropathy

Sources:
51PubMed
See all sources

Articles related to Demyelinating Polyneuropathy:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
Distal acquired demyelinating symmetric polyneuropathy progressing to classic chronic inflammatory demyelinating polyneuropathy and response to fludarabine and cyclophosphamide. (23168526)
2013
2
Severe hyponatremia as the initial sign preceding guillain-barrAc syndrome, an acute inflammatory demyelinating polyneuropathy: a case report. (23476842)
2013
3
Comparison of sensitivity and specificity among 15 criteria for chronic inflammatory demyelinating polyneuropathy. (24338746)
2013
4
Chronic inflammatory demyelinating polyneuropathy mimicking diabetic neuropathy in a young female with type 2 diabetes mellitus. (22293929)
2012
5
The efficacy of subcutaneous immunoglobulin administration in chronic inflammatory demyelinating polyneuropathy responders to intravenous immunoglobulin. (21692916)
2011
6
Systemic lupus erythematosus associated relapsing polyneuropathy: recurrent Guillain-BarrAc syndrome or chronic inflammatory demyelinating polyradiculoneuropathy? (21922475)
2011
7
SjAPgren's syndrome with chronic inflammatory demyelinating polyneuropathy. (21743193)
2011
8
Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies. (19922956)
2010
9
Chronic inflammatory demyelinating polyneuropathy after treatment with pegylated interferon alpha 2b in a patient with HIV/HCV coinfection: case report]. (20305976)
2010
10
Fatigue in chronic inflammatory demyelinating polyneuropathy. (19347932)
2009
11
Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alpha. (19252365)
2009
12
Epidemiologic variability of chronic inflammatory demyelinating polyneuropathy with different diagnostic criteria: study of a UK population. (19260065)
2009
13
Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy. (19261857)
2009
14
Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy. (19771172)
2009
15
Demyelinating findings in typical and atypical chronic inflammatory demyelinating polyneuropathy: sensitivity and specificity. (19494726)
2009
16
Demyelinating polyneuropathy with focally folded myelin sheaths in a family of Miniature Schnauzer dogs. (18809183)
2008
17
Patient and family fact sheet. Chronic inflammatory demyelinating polyneuropathy. (18332847)
2008
18
Remission of demyelinating polyneuropathy with immunoadsorption, low dose corticosteroids and anti-CD20 monoclonal antibody. (18503697)
2008
19
Neurophysiological evaluation of trigeminal and facial nerves in patients with chronic inflammatory demyelinating polyneuropathy. (17063459)
2007
20
Spreading of autoimmunity from central to peripheral myelin: two cases of clinical association between multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. (16688601)
2006
21
A neonatal diagnosis of congenital chronic inflammatory demyelinating polyneuropathy. (15991871)
2005
22
Trigeminal neuralgia in a patient with multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. (15884316)
2005
23
Changes in serum macrophage-related factors in patients with chronic inflammatory demyelinating polyneuropathy caused by intravenous immunoglobulin therapy. (12639724)
2003
24
Resolution of chronic inflammatory demyelinating polyneuropathy-associated central nervous system lesions after treatment with intravenous immunoglobulin. (12904236)
2003
25
Pathological findings in a patient with ventilatory failure and chronic inflammatory demyelinating polyneuropathy. (12678549)
2003
26
Comparison of electrodiagnostic criteria for demyelination in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). (11967643)
2002
27
Long-term efficacy of interferon-alpha in chronic inflammatory demyelinating polyneuropathy. (12173577)
2002
28
POEMS syndrome in a patient presenting with chronic inflammatory demyelinating polyneuropathy. (12378691)
2002
29
Clinical and magnetic resonance imaging evidence of brain and spinal cord demyelination in a case of chronic inflammatory demyelinating polyneuropathy. (11437170)
2001
30
Chronic inflammatory demyelinating polyneuropathy and membranous glomerulonephropathy: report of two cases. (19078657)
2001
31
Trovafloxacin-induced weakness due to a demyelinating polyneuropathy. (10832955)
2000
32
Passive transfer of demyelination by serum or IgG from chronic inflammatory demyelinating polyneuropathy patients. (10852542)
2000
33
The spectrum of chronic inflammatory demyelinating polyneuropathy. (10675657)
2000
34
Chronic inflammatory demyelinating polyneuropathy associated with membranous glomerulonephritis: case report. (10942672)
2000
35
Chronic demyelinating polyneuropathy in pregnancy treated with intravenous immunoglobulin. (10426685)
1999
36
Upper limb predominant, multifocal chronic inflammatory demyelinating polyneuropathy. (10366230)
1999
37
Conduction block and continuous motor unit activity in chronic acquired demyelinating polyneuropathy. (10204791)
1999
38
Micturitional disturbance in patients with chronic inflammatory demyelinating polyneuropathy. (9566423)
1998
39
Arthritis associated with circulating immune complexes following administration of intravenous immunoglobulin therapy in a patient with chronic inflammatory demyelinating polyneuropathy. (8926503)
1996
40
Acquired demyelinating polyneuropathy presenting as a pure clinical sensory syndrome. (8761278)
1996
41
Treatment of stable chronic demyelinating polyneuropathy with 3,4-diaminopyridine. (7776711)
1995
42
Motor evoked potentials to magnetic stimulation in chronic and acute inflammatory demyelinating polyneuropathy. (7630353)
1995
43
Systemic lupus erythematosus and acute demyelinating polyneuropathy. (7981996)
1994
44
Quantitative analysis of the compound muscle action potential in early acute inflammatory demyelinating polyneuropathy. (7521284)
1994
45
Chronic demyelinating polyneuropathy associated with eosinophilia-myalgia syndrome. (1534836)
1992
46
Chronic inflammatory demyelinating polyneuropathy: immunoglobulins or plasmapheresis? (1953391)
1991
47
HLA antigens in chronic inflammatory demyelinating polyneuropathy. (2313306)
1990
48
Chronic inflammatory demyelinating polyneuropathy in childhood: ultrastructural features of peripheral nerve biopsies in four cases. (2373121)
1990
49
Central lesions in chronic inflammatory demyelinating polyneuropathy: an MRI study. (2314591)
1990
50
Chronic inflammatory demyelinating polyneuropathy of infancy: a corticosteroid-responsive disorder. (3017185)
1986

Genetic Variations for Demyelinating Polyneuropathy

Expression for genes affiliated with Demyelinating Polyneuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Demyelinating Polyneuropathy

Search GEO for disease gene expression data for Demyelinating Polyneuropathy.

Pathways for genes affiliated with Demyelinating Polyneuropathy

Sources:
54Reactome, 30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2MAG, NGF
210.1CD1D, TNF, CSF1
3
Hide members
10.1IFNA2, IFNA1, TNF
410.1TNF, IFNA1, IFNA2
510.0TNF, AIF1, MAG, GDNF
6
Hide members
10.0FCGR2B, TNF, IFNA1, IFNA2
710.0FCGR2B, TNF, IFNA1, IFNA2
810.0CD28, CTLA4, TNF, CSF1
99.9IFNA2, IFNA1, TNF, CLDN5
10
Hide members
9.9IFNA2, IFNA1, TNF, CXCL9
11
Hide members
9.8CSF1, TNF, GAS6, CD28, CXCL9
12
Hide members
9.8CSF1, TNF, GAS6, CD28, CXCL9
139.8CTLA4, MAG, CNTN2, CD28, CLDN5
14
Hide members
9.8FCGR2B, CD28, TNF, IFNA1, IFNA2
15
Hide members
9.8TNF, CTLA4, CD28, FYB, FCGR2B
16
Hide members
9.8CD28, CTLA4, TNF, IFNA1, IFNA2
17
Hide members
9.4CXCL9, IFNA2, IFNA1, CSF1, TNF, CNTF

Compounds for genes affiliated with Demyelinating Polyneuropathy

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5IFNA1
2pegasys4510.4IFNA1, IFNA2
3etanercept45 50 1112.4FCGR2B, IFNA2, CSF1, TNF
4estrogen4510.4CNTN2, FCGR2B
5rantes4510.4GDNF, TNF, CSF1, IFNA1
6ivig4510.3TNF, MAG, FCGR2B, CSF1
7superoxide45 2411.3CNTF, IFNA2, FCGR2B, TNF
8il 104510.3CSF1, CTLA4, CXCL9, TNF
9imiquimod45 29 60 1113.3IFNA2, IFNA1, TNF
10dexamethasone45 50 29 1113.3IFNA1, CXCL9, GDNF, CTLA4
11bromodeoxyuridine4510.3CNTN2, CNTF, TUBB, AIF1, GDNF
12neopterin4510.3CSF1, IFNA1, IFNA2, TNF
13ifn-alpha4510.3CSF1, IFNA2, IFNA1, CXCL9
14ganglioside4510.3CTLA4, MAG, CNTF, NGF, GDNF
15zidovudine45 1111.3CSF1, IFNA1, IFNA2, CNTN2
16thalidomide45 50 60 1113.3IFNA1, CTLA4, TNF, IFNA2
17acetylcholine45 50 29 11 2414.3MAG, CTLA4, GDNF, NGF, CNTF
18bcnu4510.2IFNA2, IFNA1, CSF1
19prednisolone45 29 1112.2IFNA1, IFNA2, CSF1, TNF, NGF
20cytarabine45 50 1112.2IFNA1, CSF1, IFNA2, NGF
2112-o-tetradecanoylphorbol 13-acetate4510.2CSF1, NGF, CNTN2, IFNA2, CNTF
22ceramide4510.2CNTN2, TNF, CD1D, NGF, CD28
23retinoid4510.1CNTN2, CD1D, IFNA2, IFNA1, CSF1
24tacrolimus45 50 1112.1GDNF, IFNA1, TNF, CD28, CTLA4
25ionomycin4510.1TNF, CXCL9, CSF1, CD28, CNTN2, CTLA4
26cyclic amp45 2411.1CNTF, MAG, CNTN2, GDNF, CD28
27actinomycin d4510.1IFNA1, TNF, CNTF, NGF, CSF1, GDNF
28serine4510.1TNF, GDNF, CSF1, MAG, CTLA4, FCGR2B
29wortmannin4510.1CNTF, GAS6, CD28, GDNF, NGF, CSF1
30histamine45 29 2412.1IFNA2, TNF, NGF, CXCL9, FCGR2B, CNTF
31phosphotyrosine4510.1MAG, TUBB, CSF1, CD28, NGF, FYB
32rituximab45 50 1112.0CSF1, IFNA2, TNF, IFNA1, CTLA4, MAG
33genistein45 29 60 2 11 2415.0FCGR2B, CD28, GDNF, NGF, CNTF, CSF1
34choline45 11 2412.0CNTF, CNTN2, NGF, GDNF
35cyclosporin a45 29 6012.0NGF, CTLA4, TNF, IFNA1, CD28, CNTN2
36con a4510.0CD28, CTLA4, IFNA2
37ly2940024510.0CSF1, TNF, CNTF, CTLA4, GAS6, NGF
38threonine459.9CD28, NGF, CNTN2, MAG, CNTF, CTLA4
39pd 98,059459.9NGF, CNTF, TNF, CSF1, GDNF
40h2o2459.8GDNF, CNTF, TNF, CSF1, CNTN2, TUBB
41cysteine459.8CSF1, MAG, IFNA2, CD28, TUBB, GDNF
42retinoic acid45 2410.7CNTF, AIF1, TNF, NGF, CD1D, GDNF
43vegf459.7NGF, IFNA2, CXCL9, GDNF, CNTF, CNTN2
44phosphatidylinositol459.7CTLA4, GAS6, CSF1, CNTF, NGF, CD28
45alanine459.7IFNA2, IFNA1, CSF1, CTLA4, MAG, NGF
46tgf beta1459.7GDNF, CTLA4, CSF1, TNF
47lipid459.6TNF, GDNF, FCGR2B, TUBB, CD28, CD1D
48thymidine45 2410.6CTLA4, IFNA2, IFNA1, FCGR2B, NGF, CNTN2
49calcium45 50 11 2412.3CXCL9, FCGR2B, CLDN5, CD28, GDNF, AIF1
50tyrosine459.0NGF, AIRE, FCGR2B, FYB, CXCL9, GDNF

GO Terms for genes affiliated with Demyelinating Polyneuropathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic cupGO:00189110.3AIF1, TNF
2paranode region of axonGO:03327010.2CLDN5, MAG
3Schmidt-Lanterman incisureGO:04322010.1MAG, CLDN5
4external side of plasma membraneGO:00989710.0TNF, CTLA4, CD28, CXCL9
5extracellular spaceGO:0056159.8CXCL9, NGF, CNTF, GAS6, TNF, CSF1
6plasma membraneGO:0058869.0TUBB, CSF1, TNF, CTLA4, AIRE, MAG

Biological processes related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:04352410.1GDNF, NGF, CNTF
2humoral immune responseGO:00695910.1TNF, AIRE, CD28
3positive regulation of T cell proliferationGO:04210210.0CD28, CD1D, AIF1
4immune responseGO:0069559.9CTLA4, AIRE, CXCL9, FYB, FCGR2B
5inflammatory responseGO:0069549.9CXCL9, NGF, AIF1, TNF, CSF1, IFNA2
6signal transductionGO:0071659.4GAS6, CNTF, GDNF, CXCL9, FYB, FCGR2B

Molecular functions related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.9GDNF, NGF, CNTF, CSF1
2identical protein bindingGO:0428029.9CLDN5, CD28, CNTN2, AIRE, TNF
3cytokine activityGO:0051259.7IFNA2, CSF1, TNF, CXCL9

Products for genes affiliated with Demyelinating Polyneuropathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Demyelinating Polyneuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet