MCID: DMY001
MIFTS: 53

Demyelinating Polyneuropathy malady

Neuronal diseases category

Summaries for Demyelinating Polyneuropathy

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Demyelinating Polyneuropathy, also known as peripheral demyelinating neuropathy, is related to polyneuropathy and neuropathy. An important gene associated with Demyelinating Polyneuropathy is AIF1 (allograft inflammatory factor 1), and among its related pathways are Axonal growth inhibition (RHOA activation) and Hematopoietic cell lineage. The compounds cycloheximide and pegasys have been mentioned in the context of this disorder. Affiliated tissues include t cells, endothelial and brain, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Classifications for Demyelinating Polyneuropathy

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

demyelinating polyneuropathy 8 10
peripheral demyelinating neuropathy 8 60


External Ids:

Disease Ontology8 DOID:5214
SNOMED-CT56 23414001
NCIt39 C27062

Related Diseases for Demyelinating Polyneuropathy

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Chronic Inflammatory Demyelinating Polyneuropathy family:

demyelinating polyneuropathy Subacute Inflammatory Demyelinating Polyneuropathy

Diseases related to Demyelinating Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy32.1TUBB, IFNA2, MAG, CNTF, CD28, GDNF
2neuropathy31.0NGF, MAG
3diabetic polyneuropathy30.9NGF
4hepatitis30.7IFNA2, CTLA4, AIRE, IFNA1
5myasthenia gravis30.6CTLA4, AIRE, MAG, CD28
6melanoma30.6CTLA4, IFNA2, CSF1, CXCL9, IFNA1, TNF
7diabetes mellitus30.5AIRE, CTLA4, TNF, NGF
8hepatitis c30.5TNF, CTLA4, IFNA2, CD28, IFNA1
9multiple sclerosis30.5CXCL9, IFNA1, CSF1, TNF, CTLA4, MAG
10lupus erythematosus30.4FCGR2B
11hepatitis b30.4CTLA4, IFNA2, IFNA1
12systemic lupus erythematosus30.4FCGR2B, IFNA1, TNF, CTLA4, CD28
13myopathy30.3NGF
14pneumonia30.3TNF
15guillain-barre syndrome30.3TUBB
16glomerulonephritis30.3CXCL9, CD28, GAS6
17malaria30.3CXCL9, TNF, CNTF
18hepatocellular carcinoma30.2CTLA4, IFNA2, IFNA1, CXCL9
19arthritis30.2FCGR2B, CTLA4, CSF1, TNF, CXCL9
20amyotrophic lateral sclerosis30.2CSF1, NGF, MAG, GDNF, CNTF
21leukemia30.2IFNA2, GDNF, TNF, GAS6, CNTN2, CSF1
22peritonitis30.0TNF
23dementia30.0NGF
24alopecia30.0AIRE
25myeloid leukemia30.0CSF1
26macroglobulinemia30.0MAG
27dermatitis30.0CTLA4, CXCL9
28thyroiditis30.0CTLA4, IFNA1
29sarcoma30.0CSF1
30herpes simplex30.0GDNF, CNTN2, IFNA1
31sarcoidosis30.0TNF, CD28, CXCL9
32diabetic neuropathy30.0NGF, CNTF, GDNF
33graft versus host disease30.0TNF, CTLA4, CD28
34thrombocytopenia30.0IFNA2, IFNA1, CSF1, FCGR2B
35influenza30.0IFNA1, CD28, CXCL9
36psoriasis30.0CXCL9, TNF, CTLA4, NGF, CD28
37connective tissue disease30.0IFNA1, FCGR2B, CTLA4, TNF
38rheumatoid arthritis30.0CSF1, TNF, CTLA4, CNTN2, CD1D, CD28
39chronic polyneuropathy11.4
40chronic inflammatory demyelinating polyneuropathy10.6
41peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease10.4
42poems syndrome10.4
43pcwh syndrome10.3
44charcot-marie-tooth disease10.3
45respiratory failure10.3
46tooth disease10.3
47eosinophilia-myalgia syndrome10.2
48mononeuritis multiplex10.2
49lateral sclerosis10.2
50carpal tunnel syndrome10.2

Graphical network of the top 20 diseases related to Demyelinating Polyneuropathy:



Diseases related to demyelinating polyneuropathy

Clinical Features for Demyelinating Polyneuropathy

About this section

Drugs & Therapeutics for Demyelinating Polyneuropathy

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Demyelinating Polyneuropathy

Drug clinical trials:

Search ClinicalTrials for Demyelinating Polyneuropathy

Search NIH Clinical Center for Demyelinating Polyneuropathy

Search CenterWatch for Demyelinating Polyneuropathy

Genetic Tests for Demyelinating Polyneuropathy

About this section

Anatomical Context for Demyelinating Polyneuropathy

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Demyelinating Polyneuropathy:

32
T cells, Endothelial, Brain, Spinal cord, B cells, Bone marrow, Myeloid, Testes, Skin, Thyroid, Liver, Kidney, Heart, Bone, Dorsal root ganglion

Animal Models for Demyelinating Polyneuropathy or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Demyelinating Polyneuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.8FCGR2B, CD1D, AIRE, CTLA4, TNF, CSF1
2MP:00053799.7CSF1, TNF, GDNF, FCGR2B
3MP:00036319.4CNTN2, MAG, AIRE, CSF1, CNTF, CD1D
4MP:00053859.3GAS6, CTLA4, TNF, CSF1, NGF, CD1D
5MP:00053979.3GAS6, CTLA4, TNF, CSF1, AIRE, CNTF
6MP:00053869.3MAG, AIRE, TNF, CSF1, CNTN2, CNTF
7MP:00053879.2FCGR2B, CSF1, TNF, CTLA4, GAS6, AIRE
8MP:00053849.2GAS6, CTLA4, TNF, CSF1, AIRE, CNTF
9MP:00053769.2GAS6, CTLA4, TNF, CSF1, AIRE, CNTF
10MP:00107689.1GAS6, CTLA4, TNF, CSF1, AIRE, NGF

Publications for Demyelinating Polyneuropathy

About this section
Sources:
50PubMed
See all sources

Articles related to Demyelinating Polyneuropathy:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Long-term outcome in chronic inflammatory demyelinating polyneuropathy patients treated with intravenous immunoglobulin: a retrospective study. (23512566)
2013
2
Role of activity-dependent conduction block in the diagnosis of primary demyelinating polyneuropathy. (22922581)
2012
3
Pain intensity and distribution in chronic inflammatory demyelinating polyneuropathy. (22806382)
2012
4
Chronic inflammatory demyelinating polyneuropathy in common variable immunodeficiency. (22490776)
2012
5
Altered cerebrospinal fluid index of prealbumin, fibrinogen, and haptoglobin in patients with Guillain-BarrAc syndrome and chronic inflammatory demyelinating polyneuropathy. (21434877)
2012
6
Activity-dependent conduction block in chronic inflammatory demyelinating polyneuropathy. (21035143)
2011
7
Childhood subacute inflammatory demyelinating polyneuropathy. (22005162)
2011
8
The expression pattern of inflammatory mediators in cerebrospinal fluid differentiates Guillain-BarrAc syndrome from chronic inflammatory demyelinating polyneuropathy. (20538476)
2010
9
Coexistence of two chronic neuropathies in a young child: Charcot-Marie-Tooth disease type 1A and chronic inflammatory demyelinating polyneuropathy. (20878740)
2010
10
Familial, demyelinating sensory and motor polyneuropathy with conduction block. (19941344)
2010
11
Treatment of chronic inflammatory demyelinating polyneuropathy. (20842572)
2010
12
Derivation and validation of diagnostic criteria for chronic inflammatory demyelinating polyneuropathy. (19091330)
2009
13
Letter to the editor on a paper by Kimura A, Yoshiro H, Yuasa T. Chronic inflammatory demyelinating polyneuropathy in a patient with hyperIgEemia. J Neurol Sci 2005;231:89-93. (19560787)
2009
14
Selective vulnerability of peripheral nerves in avian riboflavin deficiency demyelinating polyneuropathy. (19112122)
2009
15
Post-influenza vaccine chronic inflammatory demyelinating polyneuropathy. (17993473)
2008
16
Acute inflammatory demyelinating polyneuropathy and a unilateral babinski/plantar reflex. (20975794)
2008
17
Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis. (17712474)
2007
18
Treatment-responsive pudendal dysfunction in chronic inflammatory demyelinating polyneuropathy. (17372137)
2007
19
Classifications and treatment responses in chronic immune-mediated demyelinating polyneuropathy. (17485651)
2007
20
Chronic inflammatory demyelinating polyneuropathy. (17324721)
2007
21
Dispersion of compound muscle action potential in hereditary neuropathies and chronic inflammatory demyelinating polyneuropathy. (16823858)
2006
22
Progressive chronic inflammatory demyelinating polyneuropathy in a child with central nervous system involvement and myopathy. (17243577)
2006
23
Chronic inflammatory demyelinating polyneuropathy in patients with systemic lupus erythematosus: prognosis and outcome. (16325658)
2005
24
Chronic inflammatory demyelinating polyneuropathy--update on pathogenesis, diagnostic criteria and therapy. (15891411)
2005
25
Chronic inflammatory demyelinating polyneuropathy in a patient with hyperIgEaemia. (15792827)
2005
26
Different types of chronic inflammatory demyelinating polyneuropathy have a different clinical course and response to treatment. (16003765)
2005
27
AMSAN variant of Guillain Barre syndrome progressing to chronic inflammatory demyelinating polyneuropathy in a patient with Marfan's syndrome and pulmonary tuberculosis. (16515122)
2005
28
Interferon beta-1a in chronic inflammatory demyelinating polyneuropathy: case report. (15476092)
2004
29
Optic nerve sheath fenestration for intracranial hypertension associated with chronic inflammatory demyelinating polyneuropathy. (15266152)
2004
30
Acute inflammatory demyelinating polyneuropathy concurrent with Evans syndrome. (12602738)
2003
31
Can electrophysiology differentiate polyneuropathy with anti-MAG/SGPG antibodies from chronic inflammatory demyelinating polyneuropathy? (11897535)
2002
32
Sural nerve T cells in demyelinating polyneuropathy associated with monoclonal gammopathy. (11810175)
2002
33
Treatment with interferon-alpha 2a in a patient with chronic inflammatory demyelinating polyneuropathy]. (10835937)
2000
34
Type I interferons and chronic inflammatory demyelinating polyneuropathy: treatment or cause? (10679706)
2000
35
Chronic inflammatory demyelinating polyneuropathy associated with dysglobulinemia: a peripheral nerve biopsy study in 18 cases. (10912921)
2000
36
Inflammatory demyelinating polyneuropathy: a complication of immunotherapy in malignant melanoma. (11061619)
2000
37
Clinicopathologic findings and prognosis of chronic inflammatory demyelinating polyneuropathy. (10025777)
1999
38
Lecture in honour of Professor Emeritus Fritz Buchthal. Acute and chronic demyelinating polyneuropathy: an overview. (10689443)
1999
39
Chronic inflammatory demyelinating polyneuropathy: treatable hypertrophic neuropathy. (10397073)
1999
40
Focal lesions area feature of chronic inflammatory demyelinating polyneuropathy (CIDP). (9845290)
1998
41
Interferon alpha-2a therapy and pregnancy. Report of a case of chronic inflammatory demyelinating polyneuropathy. (9776604)
1998
42
Mandibular nerve involvement in diabetic polyneuropathy and chronic inflammatory demyelinating polyneuropathy. (9843068)
1998
43
Current treatment in acute demyelinating polyneuropathy (Guillain-BarrAc syndrome). (10728185)
1997
44
Chronic inflammatory demyelinating polyneuropathy associated with malignant melanoma. (8618691)
1996
45
Chronic inflammatory demyelinating polyneuropathy in dogs and cats. (10975723)
1996
46
Demyelinating polyneuropathy in a patient with the tRNA(Leu)(UUR) mutation at base pair 3243 of the mitochondrial DNA. (7783887)
1995
47
Soluble interleukin-2 receptor levels in serum of patients with demyelinating polyneuropathy associated with monoclonal gammopathy. (8509797)
1993
48
Antibodies to acidic glycolipids in Guillain-BarrAc syndrome and chronic inflammatory demyelinating polyneuropathy. (1578228)
1992
49
Chronic inflammatory demyelinating polyneuropathy. Conduction failure before and during immunoglobulin or plasma therapy. (2597997)
1989
50
Focal cranial nerve involvement in chronic inflammatory demyelinating polyneuropathy: clinical and MRI evidence of peripheral and central lesions. (2809641)
1989

Genetic Variations for Demyelinating Polyneuropathy

About this section

Expression for genes affiliated with Demyelinating Polyneuropathy

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Demyelinating Polyneuropathy

Search GEO for disease gene expression data for Demyelinating Polyneuropathy.

Pathways for genes affiliated with Demyelinating Polyneuropathy

About this section
Sources:
53Reactome, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore
See all sources

Pathways related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2MAG, NGF
210.1CD1D, TNF, CSF1
3
Hide members
10.1IFNA2, IFNA1, TNF
410.1TNF, IFNA1, IFNA2
510.0TNF, AIF1, MAG, GDNF
6
Hide members
10.0FCGR2B, TNF, IFNA1, IFNA2
710.0FCGR2B, TNF, IFNA1, IFNA2
810.0CD28, CTLA4, TNF, CSF1
99.9IFNA2, IFNA1, TNF, CLDN5
10
Hide members
9.9IFNA2, IFNA1, TNF, CXCL9
11
Hide members
9.8CSF1, TNF, GAS6, CD28, CXCL9
12
Hide members
9.8CSF1, TNF, GAS6, CD28, CXCL9
139.8CTLA4, MAG, CNTN2, CD28, CLDN5
14
Hide members
9.8FCGR2B, CD28, TNF, IFNA1, IFNA2
15
Hide members
9.8TNF, CTLA4, CD28, FYB, FCGR2B
16
Hide members
9.8CD28, CTLA4, TNF, IFNA1, IFNA2
17
Hide members
9.4CXCL9, IFNA2, IFNA1, CSF1, TNF, CNTF

Compounds for genes affiliated with Demyelinating Polyneuropathy

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5IFNA1
2pegasys4410.4IFNA1, IFNA2
3etanercept44 49 1112.4FCGR2B, IFNA2, CSF1, TNF
4estrogen4410.4CNTN2, FCGR2B
5rantes4410.4GDNF, TNF, CSF1, IFNA1
6ivig4410.3TNF, MAG, FCGR2B, CSF1
7superoxide44 2411.3CNTF, IFNA2, FCGR2B, TNF
8il 104410.3CSF1, CTLA4, CXCL9, TNF
9imiquimod44 28 59 1113.3IFNA2, IFNA1, TNF
10dexamethasone44 49 28 1113.3IFNA1, CXCL9, GDNF, CTLA4
11bromodeoxyuridine4410.3CNTN2, CNTF, TUBB, AIF1, GDNF
12neopterin4410.3CSF1, IFNA1, IFNA2, TNF
13ifn-alpha4410.3CSF1, IFNA2, IFNA1, CXCL9
14ganglioside4410.3CTLA4, MAG, CNTF, NGF, GDNF
15zidovudine44 1111.3CSF1, IFNA1, IFNA2, CNTN2
16thalidomide44 49 59 1113.3IFNA1, CTLA4, TNF, IFNA2
17acetylcholine44 49 28 11 2414.3MAG, CTLA4, GDNF, NGF, CNTF
18bcnu4410.2IFNA2, IFNA1, CSF1
19prednisolone44 28 1112.2IFNA1, IFNA2, CSF1, TNF, NGF
20cytarabine44 49 1112.2IFNA1, CSF1, IFNA2, NGF
2112-o-tetradecanoylphorbol 13-acetate4410.2CSF1, NGF, CNTN2, IFNA2, CNTF
22ceramide4410.2CNTN2, TNF, CD1D, NGF, CD28
23retinoid4410.1CNTN2, CD1D, IFNA2, IFNA1, CSF1
24tacrolimus44 49 1112.1GDNF, IFNA1, TNF, CD28, CTLA4
25ionomycin4410.1TNF, CXCL9, CSF1, CD28, CNTN2, CTLA4
26cyclic amp44 2411.1CNTF, MAG, CNTN2, GDNF, CD28
27actinomycin d4410.1IFNA1, TNF, CNTF, NGF, CSF1, GDNF
28serine4410.1TNF, GDNF, CSF1, MAG, CTLA4, FCGR2B
29wortmannin4410.1CNTF, GAS6, CD28, GDNF, NGF, CSF1
30histamine44 28 2412.1IFNA2, TNF, NGF, CXCL9, FCGR2B, CNTF
31phosphotyrosine4410.1MAG, TUBB, CSF1, CD28, NGF, FYB
32rituximab44 49 1112.0CSF1, IFNA2, TNF, IFNA1, CTLA4, MAG
33genistein44 28 59 2 11 2415.0FCGR2B, CD28, GDNF, NGF, CNTF, CSF1
34choline44 11 2412.0CNTF, CNTN2, NGF, GDNF
35cyclosporin a44 28 5912.0NGF, CTLA4, TNF, IFNA1, CD28, CNTN2
36con a4410.0CD28, CTLA4, IFNA2
37ly2940024410.0CSF1, TNF, CNTF, CTLA4, GAS6, NGF
38threonine449.9CD28, NGF, CNTN2, MAG, CNTF, CTLA4
39pd 98,059449.9NGF, CNTF, TNF, CSF1, GDNF
40h2o2449.8GDNF, CNTF, TNF, CSF1, CNTN2, TUBB
41cysteine449.8CSF1, MAG, IFNA2, CD28, TUBB, GDNF
42retinoic acid44 2410.7CNTF, AIF1, TNF, NGF, CD1D, GDNF
43vegf449.7NGF, IFNA2, CXCL9, GDNF, CNTF, CNTN2
44phosphatidylinositol449.7CTLA4, GAS6, CSF1, CNTF, NGF, CD28
45alanine449.7IFNA2, IFNA1, CSF1, CTLA4, MAG, NGF
46tgf beta1449.7GDNF, CTLA4, CSF1, TNF
47lipid449.6TNF, GDNF, FCGR2B, TUBB, CD28, CD1D
48thymidine44 2410.6CTLA4, IFNA2, IFNA1, FCGR2B, NGF, CNTN2
49calcium44 49 11 2412.3CXCL9, FCGR2B, CLDN5, CD28, GDNF, AIF1
50tyrosine449.0NGF, AIRE, FCGR2B, FYB, CXCL9, GDNF

GO Terms for genes affiliated with Demyelinating Polyneuropathy

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic cupGO:00189110.3AIF1, TNF
2paranode region of axonGO:03327010.2CLDN5, MAG
3Schmidt-Lanterman incisureGO:04322010.1MAG, CLDN5
4external side of plasma membraneGO:00989710.0TNF, CTLA4, CD28, CXCL9
5extracellular spaceGO:0056159.8CXCL9, NGF, CNTF, GAS6, TNF, CSF1
6plasma membraneGO:0058869.0TUBB, CSF1, TNF, CTLA4, AIRE, MAG

Biological processes related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:04352410.1GDNF, NGF, CNTF
2humoral immune responseGO:00695910.1TNF, AIRE, CD28
3positive regulation of T cell proliferationGO:04210210.0CD28, CD1D, AIF1
4immune responseGO:0069559.9CTLA4, AIRE, CXCL9, FYB, FCGR2B
5inflammatory responseGO:0069549.9CXCL9, NGF, AIF1, TNF, CSF1, IFNA2
6signal transductionGO:0071659.4GAS6, CNTF, GDNF, CXCL9, FYB, FCGR2B

Molecular functions related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.9GDNF, NGF, CNTF, CSF1
2identical protein bindingGO:0428029.9CLDN5, CD28, CNTN2, AIRE, TNF
3cytokine activityGO:0051259.7IFNA2, CSF1, TNF, CXCL9

Products for genes affiliated with Demyelinating Polyneuropathy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Demyelinating Polyneuropathy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet