MCID: DMY001
MIFTS: 53

Demyelinating Polyneuropathy malady

Neuronal diseases category

Summaries for Demyelinating Polyneuropathy

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32MalaCards
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MalaCards: Demyelinating Polyneuropathy, also known as peripheral demyelinating neuropathy, is related to polyneuropathy and neuropathy. An important gene associated with Demyelinating Polyneuropathy is AIF1 (allograft inflammatory factor 1), and among its related pathways are Axonal growth inhibition (RHOA activation) and Hematopoietic cell lineage. The compounds cycloheximide and pegasys have been mentioned in the context of this disorder. Affiliated tissues include t cells, endothelial and brain, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Classifications for Demyelinating Polyneuropathy

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

demyelinating polyneuropathy 8 10
peripheral demyelinating neuropathy 8 60


External Ids:

Disease Ontology8 DOID:5214
SNOMED-CT56 23414001
NCIt39 C27062

Related Diseases for Demyelinating Polyneuropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Chronic Inflammatory Demyelinating Polyneuropathy family:

demyelinating polyneuropathy Subacute Inflammatory Demyelinating Polyneuropathy

Diseases related to Demyelinating Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy32.1TUBB, IFNA2, MAG, CNTF, CD28, GDNF
2neuropathy31.0NGF, MAG
3diabetic polyneuropathy30.9NGF
4hepatitis30.7IFNA2, CTLA4, AIRE, IFNA1
5myasthenia gravis30.6CTLA4, AIRE, MAG, CD28
6melanoma30.6CTLA4, IFNA2, CSF1, CXCL9, IFNA1, TNF
7diabetes mellitus30.5AIRE, CTLA4, TNF, NGF
8hepatitis c30.5TNF, CTLA4, IFNA2, CD28, IFNA1
9multiple sclerosis30.5CXCL9, IFNA1, CSF1, TNF, CTLA4, MAG
10lupus erythematosus30.4FCGR2B
11hepatitis b30.4CTLA4, IFNA2, IFNA1
12systemic lupus erythematosus30.4FCGR2B, IFNA1, TNF, CTLA4, CD28
13myopathy30.3NGF
14pneumonia30.3TNF
15guillain-barre syndrome30.3TUBB
16glomerulonephritis30.3CXCL9, CD28, GAS6
17malaria30.3CXCL9, TNF, CNTF
18hepatocellular carcinoma30.2CTLA4, IFNA2, IFNA1, CXCL9
19arthritis30.2FCGR2B, CTLA4, CSF1, TNF, CXCL9
20amyotrophic lateral sclerosis30.2CSF1, NGF, MAG, GDNF, CNTF
21leukemia30.2IFNA2, GDNF, TNF, GAS6, CNTN2, CSF1
22peritonitis30.0TNF
23dementia30.0NGF
24alopecia30.0AIRE
25myeloid leukemia30.0CSF1
26macroglobulinemia30.0MAG
27dermatitis30.0CTLA4, CXCL9
28thyroiditis30.0CTLA4, IFNA1
29sarcoma30.0CSF1
30herpes simplex30.0GDNF, CNTN2, IFNA1
31sarcoidosis30.0TNF, CD28, CXCL9
32diabetic neuropathy30.0NGF, CNTF, GDNF
33graft versus host disease30.0TNF, CTLA4, CD28
34thrombocytopenia30.0IFNA2, IFNA1, CSF1, FCGR2B
35influenza30.0IFNA1, CD28, CXCL9
36psoriasis30.0CXCL9, TNF, CTLA4, NGF, CD28
37connective tissue disease30.0IFNA1, FCGR2B, CTLA4, TNF
38rheumatoid arthritis30.0CSF1, TNF, CTLA4, CNTN2, CD1D, CD28
39chronic polyneuropathy11.4
40chronic inflammatory demyelinating polyneuropathy10.6
41peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease10.4
42poems syndrome10.4
43pcwh syndrome10.3
44charcot-marie-tooth disease10.3
45respiratory failure10.3
46tooth disease10.3
47eosinophilia-myalgia syndrome10.2
48mononeuritis multiplex10.2
49lateral sclerosis10.2
50carpal tunnel syndrome10.2

Graphical network of the top 20 diseases related to Demyelinating Polyneuropathy:



Diseases related to demyelinating polyneuropathy

Clinical Features for Demyelinating Polyneuropathy

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Drugs & Therapeutics for Demyelinating Polyneuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Demyelinating Polyneuropathy

Drug clinical trials:

Search ClinicalTrials for Demyelinating Polyneuropathy

Search NIH Clinical Center for Demyelinating Polyneuropathy

Search CenterWatch for Demyelinating Polyneuropathy

Genetic Tests for Demyelinating Polyneuropathy

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Anatomical Context for Demyelinating Polyneuropathy

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32MalaCards
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MalaCards organs/tissues related to Demyelinating Polyneuropathy:

32
T cells, Endothelial, Brain, Spinal cord, B cells, Bone marrow, Myeloid, Testes, Skin, Thyroid, Liver, Kidney, Heart, Bone, Dorsal root ganglion

Animal Models for Demyelinating Polyneuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Demyelinating Polyneuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.8FCGR2B, CD1D, AIRE, CTLA4, TNF, CSF1
2MP:00053799.7CSF1, TNF, GDNF, FCGR2B
3MP:00036319.4MAG, CSF1, AIRE, FCGR2B, CLDN5, GDNF
4MP:00053859.3GDNF, CD28, CD1D, NGF, CTLA4, GAS6
5MP:00053979.3CD1D, FYB, CSF1, CD28, CNTF, AIRE
6MP:00053869.3CSF1, FCGR2B, TNF, AIRE, MAG, CNTN2
7MP:00053879.2FCGR2B, FYB, CSF1, TNF, CTLA4, GAS6
8MP:00053849.2CD28, FCGR2B, FYB, GDNF, CD1D, CNTF
9MP:00053769.2CNTF, AIRE, GAS6, CTLA4, TNF, CSF1
10MP:00107689.1AIRE, NGF, CD1D, GDNF, CXCL9, FCGR2B

Publications for Demyelinating Polyneuropathy

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50PubMed
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Articles related to Demyelinating Polyneuropathy:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Childhood chronic inflammatory demyelinating polyneuropathy: an overview of 10 cases in the modern era. (23364655)
2014
2
Chronic inflammatory demyelinating polyneuropathy and metastatic melanoma. (23968958)
2013
3
Chronic inflammatory demyelinating polyneuropathy. (23642722)
2013
4
Nerve ultrasound score in distinguishing chronic from acute inflammatory demyelinating polyneuropathy. (24070674)
2013
5
Observations on chronic inflammatory demyelinating polyneuropathy: A plea for a rigorous approach to diagnosis and treatment. (23663896)
2013
6
Intravenous immunoglobulin inhibits BAFF production in chronic inflammatory demyelinating polyneuropathy - a new mechanism of action? (23357714)
2013
7
Antibodies to contactin-1 in chronic inflammatory demyelinating polyneuropathy. (23280477)
2013
8
Is total duration of distal compound muscle action potential better than negative peak duration in the diagnosis of chronic inflammatory demyelinating polyneuropathy? (24114712)
2013
9
Comment on acute-onset chronic inflammatory demyelinating polyneuropathy versus fluctuating Guillain-BarrAc syndrome. (21922476)
2011
10
The efficacy of subcutaneous immunoglobulin administration in chronic inflammatory demyelinating polyneuropathy responders to intravenous immunoglobulin. (21692916)
2011
11
Systemic lupus erythematosus associated relapsing polyneuropathy: recurrent Guillain-BarrAc syndrome or chronic inflammatory demyelinating polyradiculoneuropathy? (21922475)
2011
12
SjAPgren's syndrome with chronic inflammatory demyelinating polyneuropathy. (21743193)
2011
13
Atypical childhood chronic inflammatory demyelinating polyneuropathy. (20589891)
2010
14
Chronic inflammatory demyelinating polyneuropathy disease activity status: recommendations for clinical research standards and use in clinical practice. (21199104)
2010
15
Acute-onset chronic inflammatory demyelinating polyneuropathy with cranial nerve involvement, dysautonomia, respiratory failure, and autoantibodies. (19918775)
2010
16
Pericarditis and chronic inflammatory demyelinating polyneuropathy during therapy with pegylated interferon alfa-2a for chronic hepatitis C. (21161021)
2010
17
Electrophysiology in chronic inflammatory demyelinating polyneuropathy with IGIV. (19260050)
2009
18
Chronic inflammatory demyelinating polyneuropathy as a possible novel component of autoimmune poly-endocrine-candidiasis-ectodermal dystrophy. (18461357)
2009
19
Acute inflammatory demyelinating polyneuropathy associated with pegylated interferon alpha 2a therapy for chronic hepatitis C virus infection. (18186575)
2008
20
Elevation of Gas6 protein concentration in cerebrospinal fluid of patients with chronic inflammatory demyelinating polyneuropathy (CIDP). (18279894)
2008
21
Rituximab in chronic inflammatory demyelinating polyneuropathy associated with diabetes mellitus. (17382963)
2007
22
Diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy. (16464406)
2006
23
Remission of chronic inflammatory demyelinating polyneuropathy after alemtuzumab (Campath 1H). (16705208)
2006
24
Treatment of refractory chronic inflammatory demyelinating polyneuropathy with interferon beta 1B. (15944862)
2005
25
Chronic inflammatory demyelinating polyneuropathy and respiratory failure. (15940387)
2005
26
Chronic Inflammatory Demyelinating Polyneuropathy. (12895398)
2003
27
88th ENMC international workshop: childhood chronic inflammatory demyelinating polyneuropathy (including revised diagnostic criteria), Naarden, The Netherlands, December 8-10, 2000. (11738363)
2002
28
Distribution patterns of demyelination correlate with clinical profiles in chronic inflammatory demyelinating polyneuropathy. (11784822)
2002
29
Wall eyed bilateral internuclear ophthalmoplegia in chronic inflammatory demyelinating polyneuropathy. (12453091)
2002
30
POEMS syndrome in a patient presenting with chronic inflammatory demyelinating polyneuropathy. (12378691)
2002
31
Sural nerve T-cell receptor Vbeta gene utilization in chronic inflammatory demyelinating polyneuropathy and vasculitic neuropathy. (11148239)
2001
32
Chronic inflammatory demyelinating polyneuropathy in childhood. (11301217)
2001
33
Age of onset influences clinical features of chronic inflammatory demyelinating polyneuropathy. (11231033)
2001
34
Visual evoked potentials study in chronic idiopathic inflammatory demyelinating polyneuropathy. (11090783)
2000
35
Chronic inflammatory demyelinating polyneuropathy: immunopathological and ultrastructural study of peripheral nerve biopsy in 42 cases. (11206333)
2000
36
Optic neuropathy in a patient with chronic inflammatory demyelinating polyneuropathy. (11584858)
2000
37
Chronic inflammatory demyelinating polyneuropathy with papillodema and response to immunoglobulins. (24276666)
2000
38
Conduction block and continuous motor unit activity in chronic acquired demyelinating polyneuropathy. (10204791)
1999
39
Asymmetrical polyneuropathy with a stepwise progressive course and well-demarcated areas of demyelination. (10417801)
1999
40
Micturitional disturbance in patients with chronic inflammatory demyelinating polyneuropathy. (9566423)
1998
41
Clinical and electrophysiological correlation in chronic inflammatory demyelinating polyneuropathy with intravenous immunoglobulin therapy: a case report. (9134822)
1997
42
High-titer immunoglobulin M antibody to nerve-specific class III beta-tubulin in the serum of a patient with sensory demyelinating polyneuropathy. (8941286)
1996
43
Treatment of chronic inflammatory demyelinating polyneuropathy with cyclosporin-A. (8708650)
1996
44
Intramyelinic edema in chronic inflammatory demyelinating polyneuropathy. (8998850)
1996
45
Concurrent myasthenia gravis and chronic inflammatory demyelinating polyneuropathy. (8756180)
1996
46
Anti-beta-tubulin antibodies have no diagnostic value in patients with chronic inflammatory demyelinating polyneuropathy. (8551323)
1995
47
Mixed nerve action potentials in acquired demyelinating polyneuropathy. (7800002)
1995
48
Anti-GM1 antibodies in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) treated with intravenous immunoglobulin (IVIg). (7929799)
1994
49
Chronic inflammatory demyelinating polyneuropathy or hereditary motor and sensory neuropathy? Diagnostic value of morphological criteria. (8310819)
1993
50
High-dose intravenous human immunoglobulin in chronic inflammatory demyelinating polyneuropathy. (2927654)
1989

Genetic Variations for Demyelinating Polyneuropathy

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Expression for genes affiliated with Demyelinating Polyneuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Demyelinating Polyneuropathy

Search GEO for disease gene expression data for Demyelinating Polyneuropathy.

Pathways for genes affiliated with Demyelinating Polyneuropathy

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53Reactome, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2NGF, MAG
210.1CSF1, TNF, CD1D
3
Hide members
10.1TNF, IFNA1, IFNA2
410.1IFNA1, IFNA2, TNF
510.0TNF, GDNF, MAG, AIF1
610.0TNF, IFNA1, IFNA2, FCGR2B
7
Hide members
10.0FCGR2B, IFNA1, IFNA2, TNF
810.0CD28, CTLA4, TNF, CSF1
99.9IFNA2, CLDN5, IFNA1, TNF
10
Hide members
9.9TNF, IFNA2, IFNA1, CXCL9
11
Hide members
9.8CXCL9, CD28, CSF1, TNF, GAS6
12
Hide members
9.8CXCL9, CD28, GAS6, TNF, CSF1
139.8CLDN5, CTLA4, MAG, CD28, CNTN2
14
Hide members
9.8TNF, IFNA1, IFNA2, CD28, FCGR2B
15
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9.8FYB, CD28, CTLA4, TNF, FCGR2B
16
Hide members
9.8CTLA4, TNF, IFNA1, IFNA2, CD28
17
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9.4GDNF, IFNA2, IFNA1, CXCL9, CSF1, TNF

Compounds for genes affiliated with Demyelinating Polyneuropathy

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5IFNA1
2pegasys4410.4IFNA1, IFNA2
3etanercept44 49 1112.4FCGR2B, IFNA2, CSF1, TNF
4estrogen4410.4CNTN2, FCGR2B
5rantes4410.4GDNF, TNF, CSF1, IFNA1
6ivig4410.3TNF, MAG, FCGR2B, CSF1
7superoxide44 2411.3CNTF, IFNA2, FCGR2B, TNF
8il 104410.3CSF1, CTLA4, CXCL9, TNF
9imiquimod44 28 59 1113.3IFNA2, IFNA1, TNF
10dexamethasone44 49 28 1113.3IFNA1, CXCL9, GDNF, CTLA4
11bromodeoxyuridine4410.3CNTN2, CNTF, TUBB, AIF1, GDNF
12neopterin4410.3CSF1, IFNA1, IFNA2, TNF
13ifn-alpha4410.3CSF1, IFNA2, IFNA1, CXCL9
14ganglioside4410.3CTLA4, MAG, CNTF, NGF, GDNF
15zidovudine44 1111.3CSF1, IFNA1, IFNA2, CNTN2
16thalidomide44 49 59 1113.3IFNA1, CTLA4, TNF, IFNA2
17acetylcholine44 49 28 11 2414.3MAG, CTLA4, GDNF, NGF, CNTF
18bcnu4410.2IFNA2, IFNA1, CSF1
19prednisolone44 28 1112.2IFNA1, IFNA2, CSF1, TNF, NGF
20cytarabine44 49 1112.2IFNA1, CSF1, IFNA2, NGF
2112-o-tetradecanoylphorbol 13-acetate4410.2CSF1, NGF, CNTN2, IFNA2, CNTF
22ceramide4410.2CNTN2, TNF, CD1D, NGF, CD28
23retinoid4410.1CNTN2, CD1D, IFNA2, IFNA1, CSF1
24tacrolimus44 49 1112.1GDNF, IFNA1, TNF, CD28, CTLA4
25ionomycin4410.1TNF, CXCL9, CSF1, CD28, CNTN2, CTLA4
26cyclic amp44 2411.1CNTF, MAG, CNTN2, GDNF, CD28
27actinomycin d4410.1IFNA1, TNF, CNTF, NGF, CSF1, GDNF
28serine4410.1TNF, GDNF, CSF1, MAG, CTLA4, FCGR2B
29wortmannin4410.1CNTF, GAS6, CD28, GDNF, NGF, CSF1
30histamine44 28 2412.1IFNA2, TNF, NGF, CXCL9, FCGR2B, CNTF
31phosphotyrosine4410.1MAG, TUBB, CSF1, CD28, NGF, FYB
32rituximab44 49 1112.0CSF1, IFNA2, TNF, IFNA1, CTLA4, MAG
33genistein44 28 59 2 11 2415.0FCGR2B, CD28, GDNF, NGF, CNTF, CSF1
34choline44 11 2412.0CNTF, CNTN2, NGF, GDNF
35cyclosporin a44 28 5912.0NGF, CTLA4, TNF, IFNA1, CD28, CNTN2
36con a4410.0CD28, CTLA4, IFNA2
37ly2940024410.0CSF1, TNF, CNTF, CTLA4, GAS6, NGF
38threonine449.9CD28, NGF, CNTN2, MAG, CNTF, CTLA4
39pd 98,059449.9NGF, CNTF, TNF, CSF1, GDNF
40h2o2449.8GDNF, CNTF, TNF, CSF1, CNTN2, TUBB
41cysteine449.8CSF1, MAG, IFNA2, CD28, TUBB, GDNF
42retinoic acid44 2410.7CNTF, AIF1, TNF, NGF, CD1D, GDNF
43vegf449.7NGF, IFNA2, CXCL9, GDNF, CNTF, CNTN2
44phosphatidylinositol449.7CTLA4, GAS6, CSF1, CNTF, NGF, CD28
45alanine449.7IFNA2, IFNA1, CSF1, CTLA4, MAG, NGF
46tgf beta1449.7GDNF, CTLA4, CSF1, TNF
47lipid449.6TNF, GDNF, FCGR2B, TUBB, CD28, CD1D
48thymidine44 2410.6CTLA4, IFNA2, IFNA1, FCGR2B, NGF, CNTN2
49calcium44 49 11 2412.3CXCL9, FCGR2B, CLDN5, CD28, GDNF, AIF1
50tyrosine449.0NGF, AIRE, FCGR2B, FYB, CXCL9, GDNF

GO Terms for genes affiliated with Demyelinating Polyneuropathy

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16Gene Ontology
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Cellular components related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic cupGO:00189110.3AIF1, TNF
2paranode region of axonGO:03327010.2CLDN5, MAG
3Schmidt-Lanterman incisureGO:04322010.1MAG, CLDN5
4external side of plasma membraneGO:00989710.0TNF, CTLA4, CD28, CXCL9
5extracellular spaceGO:0056159.8CXCL9, NGF, CNTF, GAS6, TNF, CSF1
6plasma membraneGO:0058869.0TUBB, CSF1, TNF, CTLA4, AIRE, MAG

Biological processes related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:04352410.1GDNF, NGF, CNTF
2humoral immune responseGO:00695910.1TNF, AIRE, CD28
3positive regulation of T cell proliferationGO:04210210.0CD28, CD1D, AIF1
4immune responseGO:0069559.9CTLA4, AIRE, CXCL9, FYB, FCGR2B
5inflammatory responseGO:0069549.9CXCL9, NGF, AIF1, TNF, CSF1, IFNA2
6signal transductionGO:0071659.4GAS6, CNTF, GDNF, CXCL9, FYB, FCGR2B

Molecular functions related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.9GDNF, NGF, CNTF, CSF1
2identical protein bindingGO:0428029.9CLDN5, CD28, CNTN2, AIRE, TNF
3cytokine activityGO:0051259.7IFNA2, CSF1, TNF, CXCL9

Products for genes affiliated with Demyelinating Polyneuropathy

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Sources for Demyelinating Polyneuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet