MCID: DMY001
MIFTS: 39

Demyelinating Polyneuropathy malady

Neuronal diseases, Rare diseases categories

Summaries for Demyelinating Polyneuropathy

About this section


MalaCards based summary: Demyelinating Polyneuropathy, also known as peripheral demyelinating neuropathy, is related to polyneuropathy and thrombocytopenia. An important gene associated with Demyelinating Polyneuropathy is AIF1 (allograft inflammatory factor 1), and among its related pathways is Jak-STAT signaling pathway. The compounds vitamin-e and etanercept have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related mouse phenotypes are homeostasis/metabolism and cellular.

Aliases & Classifications for Demyelinating Polyneuropathy

About this section

Demyelinating Polyneuropathy, Aliases & Descriptions:

Name: Demyelinating Polyneuropathy 9 11
 
Peripheral Demyelinating Neuropathy 9 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:5214
SNOMED-CT55 23414001
NCIt38 C27062

Related Diseases for Demyelinating Polyneuropathy

About this section

Diseases in the Demyelinating Polyneuropathy family:

Chronic Inflammatory Demyelinating Polyneuropathy

Diseases related to Demyelinating Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy32.2CNTF, IFNA2
2thrombocytopenia29.8IFNA2, FCGR2B
3chronic inflammatory demyelinating polyneuropathy11.4
4neuropathy10.8
5hepatitis10.6
6pcwh syndrome10.5
7myasthenia gravis10.5
8melanoma10.5
9charcot-marie-tooth disease10.4
10poems syndrome10.4
11tooth disease10.4
12hepatitis b10.4
13hepatitis c10.4
14guillain-barre syndrome10.4
15neurologic waardenburg-shah syndrome10.3
16systemic lupus erythematosus10.3
17hepatitis c virus10.3
18leukemia10.3
19multifocal motor neuropathy10.3
20lupus erythematosus10.3
21respiratory failure10.3
22cytomegalovirus infection10.3
23blindness10.3
24hepatocellular carcinoma10.2
25malaria10.2
26charcot-marie-tooth disease, type 1a10.2
27neuropathy, inflammatory demyelinating10.2
28arthritis10.2
29diabetic neuropathy10.2
30focal segmental glomerulosclerosis10.2
31glomerulonephritis10.2
32lateral sclerosis10.2
33mononeuritis multiplex10.2
34eosinophilia-myalgia syndrome10.2
35neuronitis10.2
36diabetic polyneuropathy10.2
37eosinophilia10.2
38glomerulosclerosis10.2
39intracranial hypertension10.2
40mononeuritis10.2
41myopathy10.2
42plasmacytoma10.2
43pneumonia10.2
44scoliosis10.2
45amyloid neuropathy10.2
46marek disease10.2
47ataxia10.2
48endotheliitis10.2
49progressive multifocal leukoencephalopathy10.2
50rheumatoid arthritis10.1

Graphical network of the top 20 diseases related to Demyelinating Polyneuropathy:



Diseases related to demyelinating polyneuropathy

Symptoms for Demyelinating Polyneuropathy

About this section

Drugs & Therapeutics for Demyelinating Polyneuropathy

About this section

Drug clinical trials:

Search ClinicalTrials for Demyelinating Polyneuropathy

Search NIH Clinical Center for Demyelinating Polyneuropathy

Genetic Tests for Demyelinating Polyneuropathy

About this section

Anatomical Context for Demyelinating Polyneuropathy

About this section

MalaCards organs/tissues related to Demyelinating Polyneuropathy:

31
T cells, Brain, Spinal cord, B cells, Endothelial, Bone marrow, Bone, Heart, Kidney, Liver, Lung, Thyroid, Skin, Testes, Myeloid, Nk cells, Dorsal root ganglion

Animal Models for Demyelinating Polyneuropathy or affiliated genes

About this section

MGI Mouse Phenotypes related to Demyelinating Polyneuropathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6GAS6, CNTF, FCGR2B, APOA4, AIRE
2MP:00053847.3AIRE, APOA4, FCGR2B, CNTF, GAS6
3MP:00053977.2GAS6, CNTF, FCGR2B, APOA4, AIRE, AIF1
4MP:00053877.1AIF1, AIRE, APOA4, FCGR2B, CNTF, GAS6

Publications for Demyelinating Polyneuropathy

About this section

Articles related to Demyelinating Polyneuropathy:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Sialylated IgG-Fc: a novel biomarker of chronic inflammatory demyelinating polyneuropathy. (25814494)
2015
2
A case of cauda equina syndrome in early-onset chronic inflammatory demyelinating polyneuropathy clinically similar to charcot-marie-tooth disease type 1. (25237436)
2014
3
Distal acquired demyelinating symmetric polyneuropathy progressing to classic chronic inflammatory demyelinating polyneuropathy and response to fludarabine and cyclophosphamide. (23168526)
2013
4
Chronic inflammatory demyelinating polyneuropathy and metastatic melanoma. (23968958)
2013
5
POEMS syndrome presenting with acute demyelinating polyneuropathy: increased terminal latency indices and uniform demyelination. (23812201)
2013
6
Subacute inflammatory demyelinating polyneuropathy disclosed by massive nerve root enhancement in CMT1A. (22173780)
2012
7
Brucellosis manifesting as chronic inflammatory demyelinating polyneuropathy. (22728867)
2012
8
Clinical analysis and outcomes of amyotrophic lateral sclerosis with demyelinating polyneuropathy. (22214357)
2012
9
Amyloid neuropathy mimicking chronic inflammatory demyelinating polyneuropathy. (22190302)
2012
10
Comment on acute-onset chronic inflammatory demyelinating polyneuropathy versus fluctuating Guillain-BarrAc syndrome. (21922476)
2011
11
Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies. (19922956)
2010
12
Atypical childhood chronic inflammatory demyelinating polyneuropathy. (20589891)
2010
13
Alemtuzumab in the treatment of IVIG-dependent chronic inflammatory demyelinating polyneuropathy. (20049473)
2010
14
Chronic inflammatory demyelinating polyneuropathy responsive to mycophenolate mofetil therapy. (20176598)
2010
15
The expression pattern of inflammatory mediators in cerebrospinal fluid differentiates Guillain-BarrAc syndrome from chronic inflammatory demyelinating polyneuropathy. (20538476)
2010
16
Electrophysiology in chronic inflammatory demyelinating polyneuropathy with IGIV. (19260050)
2009
17
Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy. (19915301)
2009
18
Fatigue in chronic inflammatory demyelinating polyneuropathy. (19347932)
2009
19
Motor variant of chronic inflammatory demyelinating polyneuropathy in a child. (18486826)
2008
20
Post-influenza vaccine chronic inflammatory demyelinating polyneuropathy. (17993473)
2008
21
A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy. (17306302)
2007
22
Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis. (17712474)
2007
23
Treatment-responsive pudendal dysfunction in chronic inflammatory demyelinating polyneuropathy. (17372137)
2007
24
Demyelinating polyneuropathy in Leber hereditary optic neuropathy. (16690316)
2006
25
High-dose cyclophosphamide results in long-term disease remission with restoration of a normal quality of life in patients with severe refractory chronic inflammatory demyelinating polyneuropathy. (15703014)
2005
26
Intractable chronic inflammatory demyelinating polyneuropathy treated successfully with ciclosporin. (16024890)
2005
27
Chronic inflammatory demyelinating polyneuropathy in patients with systemic lupus erythematosus: prognosis and outcome. (16325658)
2005
28
Acute inflammatory demyelinating polyneuropathy in patients with pregnancy. (15269509)
2004
29
Chronic inflammatory demyelinating polyneuropathy after Campylobacter jejuni infection mimicking vasculitic mononeuritis multiplex in a diabetic. (15104697)
2004
30
Chronic Inflammatory Demyelinating Polyneuropathy. (12895398)
2003
31
Azathioprine hypersensitivity in a patient with peripheral demyelinating polyneuropathy. (12786856)
2003
32
Chronic demyelinating polyneuropathy in graft-versus-host disease following allogeneic bone marrow transplantation. (12030409)
2002
33
Subarachnoid block for a patient with progressive chronic inflammatory demyelinating polyneuropathy. (11682419)
2001
34
Clinical and magnetic resonance imaging evidence of brain and spinal cord demyelination in a case of chronic inflammatory demyelinating polyneuropathy. (11437170)
2001
35
Trovafloxacin-induced weakness due to a demyelinating polyneuropathy. (10832955)
2000
36
Activity-dependent excitability changes in chronic inflammatory demyelinating polyneuropathy: A microneurographic study. (10398208)
1999
37
Focal lesions area feature of chronic inflammatory demyelinating polyneuropathy (CIDP). (9845290)
1998
38
Magnetic resonance imaging at the demyelinative foci in chronic inflammatory demyelinating polyneuropathy. (9109870)
1997
39
Chronic inflammatory demyelinating polyneuropathy (CIDP) in diabetics. (8902721)
1996
40
High-titer immunoglobulin M antibody to nerve-specific class III beta-tubulin in the serum of a patient with sensory demyelinating polyneuropathy. (8941286)
1996
41
Treatment of patients with chronic inflammatory demyelinating polyneuropathy. (8881435)
1996
42
Chronic inflammatory demyelinating polyneuropathy. (8907837)
1994
43
Magnetic resonance imaging of the cauda equina in chronic inflammatory demyelinating polyneuropathy. (8388677)
1993
44
Susceptibility to demyelinating polyneuropathy in plasma cell dyscrasia may be influenced by amino acid position 9 of the HLA-DR beta chain. (7681445)
1993
45
Chronic inflammatory demyelinating polyneuropathy in childhood: clinical and electrophysiological features. (1657385)
1991
46
CNS involvement in chronic inflammatory demyelinating polyneuropathy: an electrophysiological and MRI study. (1935761)
1991
47
Chronic inflammatory demyelinating polyneuropathy. Conduction failure before and during immunoglobulin or plasma therapy. (2597997)
1989
48
Chronic inflammatory demyelinating polyneuropathy of infancy: a corticosteroid-responsive disorder. (3017185)
1986
49
Successful plasma exchange for a patient with chronic demyelinating polyneuropathy and cold agglutinin disease due to anti-Pra. (3009423)
1986
50
Plasma exchange as sole treatment for chronic inflammatory demyelinating polyneuropathy. (3702800)
1986

Variations for Demyelinating Polyneuropathy

About this section

Expression for genes affiliated with Demyelinating Polyneuropathy

About this section
Search GEO for disease gene expression data for Demyelinating Polyneuropathy.

Pathways for genes affiliated with Demyelinating Polyneuropathy

About this section

Pathways related to Demyelinating Polyneuropathy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Type III interferon signaling36
9.4CNTF, IFNA2

Compounds for genes affiliated with Demyelinating Polyneuropathy

About this section
Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Demyelinating Polyneuropathy according to GeneCards Suite gene sharing:

(show all 16)
idCompoundScoreTop Affiliating Genes
1vitamin-e439.5CNTF, IFNA2
2etanercept43 49 1211.5IFNA2, FCGR2B
3bromodeoxyuridine439.4CNTF, AIF1
4rituximab43 49 1211.4IFNA2, FCGR2B
5agarose439.3APOA4, IFNA2
6histidine439.3APOA4, IFNA2, CNTF
7fatty acid439.2APOA4, IFNA2, CNTF
8vegf438.9IFNA2, CNTF, GAS6
9histamine43 28 2410.9CNTF, IFNA2, FCGR2B
10superoxide43 249.8CNTF, IFNA2, FCGR2B
11thymidine43 249.8FCGR2B, IFNA2, CNTF
12phosphatidylinositol438.5GAS6, CNTF, FCGR2B
13lipid438.4APOA4, FCGR2B, IFNA2, CNTF
14serine438.2AIRE, APOA4, FCGR2B, CNTF
15calcium43 49 24 1211.1GAS6, CNTF, FCGR2B, AIF1
16tyrosine437.8GAS6, CNTF, IFNA2, FCGR2B, AIRE

GO Terms for genes affiliated with Demyelinating Polyneuropathy

About this section

Cellular components related to Demyelinating Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5GAS6, CNTF, IFNA2, APOA4

Biological processes related to Demyelinating Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.4CNTF, IFNA2

Products for genes affiliated with Demyelinating Polyneuropathy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Demyelinating Polyneuropathy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet