MCID: DMY001
MIFTS: 46

Demyelinating Polyneuropathy malady

Neuronal diseases, Rare diseases categories

Summaries for Demyelinating Polyneuropathy

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34MalaCards
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MalaCards: Demyelinating Polyneuropathy, also known as peripheral demyelinating neuropathy, is related to polyneuropathy and type 1 diabetes mellitus. An important gene associated with Demyelinating Polyneuropathy is AIF1 (allograft inflammatory factor 1), and among its related pathways is Jak-STAT signaling pathway. The compounds vitamin-e and etanercept have been mentioned in the context of this disorder. Affiliated tissues include t cells, endothelial and brain, and related mouse phenotypes are homeostasis/metabolism and cellular.

Aliases & Classifications for Demyelinating Polyneuropathy

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

demyelinating polyneuropathy 9 11
peripheral demyelinating neuropathy 9 63


External Ids:

Disease Ontology9 DOID:5214
SNOMED-CT59 23414001
NCIt41 C27062

Related Diseases for Demyelinating Polyneuropathy

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Chronic Inflammatory Demyelinating Polyneuropathy family:

demyelinating polyneuropathy Subacute Inflammatory Demyelinating Polyneuropathy

Diseases related to Demyelinating Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy32.2CNTF, IFNA2
2type 1 diabetes mellitus30.1APOA4, AIRE
3thrombocytopenia30.0IFNA2, FCGR2B
4chronic inflammatory demyelinating polyneuropathy11.4
5neuropathy10.8
6hepatitis10.5
7subacute inflammatory demyelinating polyneuropathy10.5
8peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease10.5
9melanoma10.5
10myasthenia gravis10.5
11poems syndrome10.4
12diabetes mellitus10.4
13hepatitis c10.4
14multiple sclerosis10.4
15blindness10.4
16pcwh syndrome10.3
17hepatitis b10.3
18systemic lupus erythematosus10.3
19charcot-marie-tooth disease10.3
20lupus erythematosus10.3
21respiratory failure10.3
22tooth disease10.3
23multifocal motor neuropathy10.3
24cytomegalovirus infection10.3
25hepatitis c virus10.3
26lateral sclerosis10.2
27mononeuritis multiplex10.2
28eosinophilia-myalgia syndrome10.2
29neuronitis10.2
30diabetic polyneuropathy10.2
31carpal tunnel syndrome10.2
32amyotrophic lateral sclerosis10.2
33arthritis10.2
34eosinophilia10.2
35glomerulonephritis10.2
36guillain-barre syndrome10.2
37hepatocellular carcinoma10.2
38hypertension10.2
39intracranial hypertension10.2
40leukemia10.2
41malaria10.2
42mononeuritis10.2
43myopathy10.2
44plasmacytoma10.2
45pneumonia10.2
46tuberculosis10.2
47amyloid neuropathy10.2
48neuropathy, inflammatory demyelinating10.2
49endotheliitis10.2
50progressive multifocal leukoencephalopathy10.2

Graphical network of the top 20 diseases related to Demyelinating Polyneuropathy:



Diseases related to demyelinating polyneuropathy

Symptoms for Demyelinating Polyneuropathy

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Drugs & Therapeutics for Demyelinating Polyneuropathy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Demyelinating Polyneuropathy

Drug clinical trials:

Search ClinicalTrials for Demyelinating Polyneuropathy

Search NIH Clinical Center for Demyelinating Polyneuropathy

Search CenterWatch for Demyelinating Polyneuropathy

Genetic Tests for Demyelinating Polyneuropathy

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Anatomical Context for Demyelinating Polyneuropathy

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34MalaCards
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MalaCards organs/tissues related to Demyelinating Polyneuropathy:

34
T cells, Endothelial, Brain, Spinal cord, B cells, Skin, Myeloid, Thyroid, Heart, Bone marrow, Testes, Kidney, Bone, Liver, Dorsal root ganglion

Animal Models for Demyelinating Polyneuropathy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Demyelinating Polyneuropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6GAS6, CNTF, FCGR2B, APOA4, AIRE
2MP:00053847.3AIRE, APOA4, FCGR2B, CNTF, GAS6
3MP:00053977.2GAS6, CNTF, FCGR2B, APOA4, AIRE, AIF1
4MP:00053877.1AIF1, AIRE, APOA4, FCGR2B, CNTF, GAS6

Publications for Demyelinating Polyneuropathy

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Sources:
53PubMed
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Articles related to Demyelinating Polyneuropathy:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Distal acquired demyelinating symmetric polyneuropathy progressing to classic chronic inflammatory demyelinating polyneuropathy and response to fludarabine and cyclophosphamide. (23168526)
2013
2
Chronic inflammatory demyelinating polyneuropathy and metastatic melanoma. (23968958)
2013
3
POEMS syndrome presenting with acute demyelinating polyneuropathy: increased terminal latency indices and uniform demyelination. (23812201)
2013
4
Severe hyponatremia as the initial sign preceding guillain-barrAc syndrome, an acute inflammatory demyelinating polyneuropathy: a case report. (23476842)
2013
5
Subacute inflammatory demyelinating polyneuropathy disclosed by massive nerve root enhancement in CMT1A. (22173780)
2012
6
Brucellosis manifesting as chronic inflammatory demyelinating polyneuropathy. (22728867)
2012
7
Clinical analysis and outcomes of amyotrophic lateral sclerosis with demyelinating polyneuropathy. (22214357)
2012
8
Amyloid neuropathy mimicking chronic inflammatory demyelinating polyneuropathy. (22190302)
2012
9
Comment on acute-onset chronic inflammatory demyelinating polyneuropathy versus fluctuating Guillain-BarrAc syndrome. (21922476)
2011
10
Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies. (19922956)
2010
11
Atypical childhood chronic inflammatory demyelinating polyneuropathy. (20589891)
2010
12
Alemtuzumab in the treatment of IVIG-dependent chronic inflammatory demyelinating polyneuropathy. (20049473)
2010
13
Chronic inflammatory demyelinating polyneuropathy responsive to mycophenolate mofetil therapy. (20176598)
2010
14
The expression pattern of inflammatory mediators in cerebrospinal fluid differentiates Guillain-BarrAc syndrome from chronic inflammatory demyelinating polyneuropathy. (20538476)
2010
15
Electrophysiology in chronic inflammatory demyelinating polyneuropathy with IGIV. (19260050)
2009
16
Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy. (19915301)
2009
17
Fatigue in chronic inflammatory demyelinating polyneuropathy. (19347932)
2009
18
Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alpha. (19252365)
2009
19
Motor variant of chronic inflammatory demyelinating polyneuropathy in a child. (18486826)
2008
20
Post-influenza vaccine chronic inflammatory demyelinating polyneuropathy. (17993473)
2008
21
A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy. (17306302)
2007
22
Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis. (17712474)
2007
23
Treatment-responsive pudendal dysfunction in chronic inflammatory demyelinating polyneuropathy. (17372137)
2007
24
Demyelinating polyneuropathy in Leber hereditary optic neuropathy. (16690316)
2006
25
High-dose cyclophosphamide results in long-term disease remission with restoration of a normal quality of life in patients with severe refractory chronic inflammatory demyelinating polyneuropathy. (15703014)
2005
26
Intractable chronic inflammatory demyelinating polyneuropathy treated successfully with ciclosporin. (16024890)
2005
27
Chronic inflammatory demyelinating polyneuropathy in patients with systemic lupus erythematosus: prognosis and outcome. (16325658)
2005
28
Acute inflammatory demyelinating polyneuropathy in patients with pregnancy. (15269509)
2004
29
Chronic inflammatory demyelinating polyneuropathy after Campylobacter jejuni infection mimicking vasculitic mononeuritis multiplex in a diabetic. (15104697)
2004
30
Chronic Inflammatory Demyelinating Polyneuropathy. (12895398)
2003
31
Azathioprine hypersensitivity in a patient with peripheral demyelinating polyneuropathy. (12786856)
2003
32
Chronic demyelinating polyneuropathy in graft-versus-host disease following allogeneic bone marrow transplantation. (12030409)
2002
33
Subarachnoid block for a patient with progressive chronic inflammatory demyelinating polyneuropathy. (11682419)
2001
34
Clinical and magnetic resonance imaging evidence of brain and spinal cord demyelination in a case of chronic inflammatory demyelinating polyneuropathy. (11437170)
2001
35
Trovafloxacin-induced weakness due to a demyelinating polyneuropathy. (10832955)
2000
36
Activity-dependent excitability changes in chronic inflammatory demyelinating polyneuropathy: A microneurographic study. (10398208)
1999
37
Focal lesions area feature of chronic inflammatory demyelinating polyneuropathy (CIDP). (9845290)
1998
38
Magnetic resonance imaging at the demyelinative foci in chronic inflammatory demyelinating polyneuropathy. (9109870)
1997
39
Chronic inflammatory demyelinating polyneuropathy (CIDP) in diabetics. (8902721)
1996
40
High-titer immunoglobulin M antibody to nerve-specific class III beta-tubulin in the serum of a patient with sensory demyelinating polyneuropathy. (8941286)
1996
41
Treatment of patients with chronic inflammatory demyelinating polyneuropathy. (8881435)
1996
42
Chronic inflammatory demyelinating polyneuropathy. (8907837)
1994
43
Magnetic resonance imaging of the cauda equina in chronic inflammatory demyelinating polyneuropathy. (8388677)
1993
44
Susceptibility to demyelinating polyneuropathy in plasma cell dyscrasia may be influenced by amino acid position 9 of the HLA-DR beta chain. (7681445)
1993
45
Chronic inflammatory demyelinating polyneuropathy in childhood: clinical and electrophysiological features. (1657385)
1991
46
CNS involvement in chronic inflammatory demyelinating polyneuropathy: an electrophysiological and MRI study. (1935761)
1991
47
Chronic inflammatory demyelinating polyneuropathy. Conduction failure before and during immunoglobulin or plasma therapy. (2597997)
1989
48
Chronic inflammatory demyelinating polyneuropathy of infancy: a corticosteroid-responsive disorder. (3017185)
1986
49
Successful plasma exchange for a patient with chronic demyelinating polyneuropathy and cold agglutinin disease due to anti-Pra. (3009423)
1986
50
Plasma exchange as sole treatment for chronic inflammatory demyelinating polyneuropathy. (3702800)
1986

Variations for Demyelinating Polyneuropathy

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Expression for genes affiliated with Demyelinating Polyneuropathy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Demyelinating Polyneuropathy

Search GEO for disease gene expression data for Demyelinating Polyneuropathy.

Pathways for genes affiliated with Demyelinating Polyneuropathy

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51PathCards, 31KEGG, 39NCBI BioSystems Database
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Pathways related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Type III interferon signaling39
9.4CNTF, IFNA2

Compounds for genes affiliated with Demyelinating Polyneuropathy

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB
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Compounds related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1vitamin-e469.5CNTF, IFNA2
2etanercept46 52 1211.5IFNA2, FCGR2B
3bromodeoxyuridine469.4CNTF, AIF1
4rituximab46 52 1211.4IFNA2, FCGR2B
5agarose469.3APOA4, IFNA2
6histidine469.3APOA4, IFNA2, CNTF
7fatty acid469.2APOA4, IFNA2, CNTF
8vegf468.9IFNA2, CNTF, GAS6
9histamine46 30 2510.9CNTF, IFNA2, FCGR2B
10superoxide46 259.8CNTF, IFNA2, FCGR2B
11thymidine46 259.8FCGR2B, IFNA2, CNTF
12phosphatidylinositol468.5GAS6, CNTF, FCGR2B
13lipid468.4APOA4, FCGR2B, IFNA2, CNTF
14serine468.2AIRE, APOA4, FCGR2B, CNTF
15calcium46 52 25 1211.1GAS6, CNTF, FCGR2B, AIF1
16tyrosine467.8GAS6, CNTF, IFNA2, FCGR2B, AIRE

GO Terms for genes affiliated with Demyelinating Polyneuropathy

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17Gene Ontology
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Cellular components related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5GAS6, CNTF, IFNA2, APOA4

Biological processes related to Demyelinating Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.4CNTF, IFNA2

Products for genes affiliated with Demyelinating Polyneuropathy

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Sources for Demyelinating Polyneuropathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet