MCID: DND002
MIFTS: 48

Dendritic Cell Sarcoma malady

Cancer diseases, Blood diseases, Rare diseases categories

Summaries for Dendritic Cell Sarcoma

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Disease Ontology:9 A histiocytic and dendritic cell cancer that is mainly located in lymph nodes.

MalaCards based summary: Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, not otherwise specified, is related to follicular dendritic cell sarcoma and pemphigus. An important gene associated with Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Complement Pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cr2+ and mycophenolate sodium have been mentioned in the context of this disorder. Affiliated tissues include lymph nodes, lymph node and tonsil, and related mouse phenotypes are mortality/aging and hematopoietic system.

Aliases & Classifications for Dendritic Cell Sarcoma

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Sources:
9Disease Ontology, 11DISEASES, 60UMLS, 47Orphanet, 55SNOMED-CT, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Dendritic Cell Sarcoma, Aliases & Descriptions:

Name: Dendritic Cell Sarcoma 9 11
Dendritic Cell Sarcoma, Not Otherwise Specified 9 60
 
Dendritic Cell Sarcoma Not Otherwise Specified 47
Dendritic Cell Sarcoma, Interdigitating 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


External Ids:

Disease Ontology9 DOID:7849
NCIt38 C27260
Orphanet47 86903
ICD10 via Orphanet26 C96.4
UMLS via Orphanet61 C1301364
ICD1025 C96.4

Related Diseases for Dendritic Cell Sarcoma

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Diseases related to Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1follicular dendritic cell sarcoma32.7PPL
2pemphigus31.3PPL, DSP, DSG1, DSG3, EVPL
3sarcoma31.1PPL, EVPL, CR2, FSCN1, VIM, DSG1
4follicular lymphoma30.8CR2, CR1, FCER2
5thymoma30.7PPL, DSP, EVPL
6langerhans-cell histiocytosis30.6FSCN1, CD68
7chronic lymphocytic leukemia30.6FCER2, IL2RA, CR1, CR2
8leukemia30.4TP53, FCER2, IL2RA, CR1, CR2, EVPL
9leiomyosarcoma30.4TP53, VIM, CR2
10histiocytosis30.0FSCN3, FSCN2, FSCN1, CD68
11melanoma29.6TP53, DSG1, VIM, FSCN1, CR1, CD68
12interdigitating dendritic cell sarcoma11.0
13tonsillitis10.7
14paraneoplastic pemphigus10.7
15castleman's disease10.6
16palmoplantar keratoderma, nonepidermolytic10.6EVPL
17mediastinitis10.5
18pemphigus vegetans10.5DSG1
19hailey-hailey disease10.5DSP
20hypersensitivity syndrome, carbamazepine-induced10.5DSG1
21subcorneal pustular dermatosis10.5DSG1
22thyroiditis10.5
23multicentric castleman’s disease10.4FSCN1, DSG3
24choroid plexus papilloma10.4TP53
25epidermolysis bullosa acquisita10.4DSG1
26pemphigus erythematosus10.4DSG3, DSP
27myasthenia gravis10.4
28cervicitis10.4
29bullous skin disease10.3DSG1, DSG3, EVPL
30keratoderma10.3DSG1, DSP
31bullous pemphigoid10.3EVPL, DSP, PPL
32keratosis10.3DSP
33palmoplantar keratosis10.3DSP, DSG1
34hepatitis10.3
35pharyngitis10.3
36dendritic cell tumor10.3
37fibrous histiocytoma10.3VIM, FSCN1
38anaplastic large cell lymphoma10.3IL2RA, FSCN1, CLU
39pemphigus foliaceus10.2PPL, DSG1, DSG3, EVPL
40allergic asthma10.2CR2, IL2RA, FCER2
41burkitt lymphoma10.2CR2, CXCL13, FCER2
42reticulosarcoma10.2CLU, FSCN1, CD68
43skin disease10.2DSG3, DSG1, DSP, FCER2
44lymphoma, non-hodgkin10.2FCER2, FSCN1, IL2RA, CR2
45membranous glomerulonephritis, antenatal10.2CLU, CR1
46esophageal cancer10.2TP53, DSG1, FSCN1
47sarcoidosis 110.2FCER2, IL2RA, CR1
48kaposi sarcoma10.2
49retroperitoneal leiomyosarcoma10.2
50nasopharyngitis10.2

Graphical network of the top 20 diseases related to Dendritic Cell Sarcoma:



Diseases related to dendritic cell sarcoma

Symptoms for Dendritic Cell Sarcoma

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Drugs & Therapeutics for Dendritic Cell Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Dendritic Cell Sarcoma

Search NIH Clinical Center for Dendritic Cell Sarcoma

Genetic Tests for Dendritic Cell Sarcoma

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Anatomical Context for Dendritic Cell Sarcoma

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MalaCards organs/tissues related to Dendritic Cell Sarcoma:

31
Lymph node, Tonsil, Liver, Bone, Spleen, Thyroid, Bone marrow, Lung, T cells, Brain, Small intestine, Colon, Breast, Skin, Kidney, Pancreas, Salivary gland, Testis, Cervix, B cells, Appendix

FMA organs/tissues related to Dendritic Cell Sarcoma:

14
Lymph nodes

Animal Models for Dendritic Cell Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Dendritic Cell Sarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0FCER2, CLDN1, DSP, DSG3, VIM, IL2RA
2MP:00053977.3TP53, FCER2, DSG3, VIM, CXCL13, IL2RA
3MP:00053847.2TP53, FCER2, DSP, DSG3, VIM, FSCN1
4MP:00053877.0CD68, TP53, FCER2, CLU, DSG3, VIM

Publications for Dendritic Cell Sarcoma

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Articles related to Dendritic Cell Sarcoma:

(show top 50)    (show all 222)
idTitleAuthorsYear
1
Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature. (25893828)
2015
2
Follicular dendritic cell sarcoma of the tonsil. (25512260)
2015
3
Follicular dendritic cell sarcoma of the right tonsil: A case report and literature review. (25621026)
2015
4
Intraperitoneal follicular dendritic cell sarcoma: role of chemotherapy and bone marrow allotransplantation in locally advanced disease? (25698886)
2015
5
Paraneoplastic pemphigus associated with primary pulmonar follicular dendritic cell sarcoma showing good response to treatment. (25388966)
2014
6
Interdigitating dendritic cell sarcoma presenting in the kidney combined with retroperitoneal leiomyosarcoma: A case report and literature review. (24396471)
2014
7
The genetics of interdigitating dendritic cell sarcoma share some changes with Langerhans cell histiocytosis in select cases. (24321462)
2014
8
Interdigitating dendritic cell sarcoma presenting in the skin: diagnosis and the role of surgical resection, chemotherapy and radiotherapy in management. (25568750)
2014
9
Extranodal follicular dendritic cell sarcoma of the soft palate: a case report. (25674273)
2014
10
Regulation of the exopolysaccharide from an anamorph of Cordyceps sinensis on dendritic cell sarcoma (DCS) cell line. (22610670)
2013
11
Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of six cases with increased IgG4-positive plasma cells. (23714251)
2013
12
A rare case of follicular dendritic cell sarcoma involving multiple bones. (23640234)
2013
13
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
14
Interdigitating dendritic cell sarcoma complicated with paraneoplastic pemphigus after surgery of resection. (23652075)
2013
15
Interdigitating dendritic cell sarcoma presenting simultaneously with acute myelomonocytic leukemia: report of a rare case and literature review. (23605368)
2013
16
Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. (23755890)
2013
17
Interdigitating dendritic cell sarcoma occured alone in axilla. (22563543)
2012
18
Pathology quiz case 1. Follicular dendritic cell sarcoma (FDS). (22801898)
2012
19
Extranodal follicular dendritic cell sarcoma with rapid growth in parapharynx: a case report. (23110021)
2012
20
Computed tomography and 18F-fluoro-2-deoxyglucose positron emission tomography findings of primary pulmonary follicular dendritic cell sarcoma: case report and a literature review. (21795995)
2012
21
Small intestine perforation due to metastatic uterine cervix interdigitating dendritic cell sarcoma: a rare manifestation of a rare disease. (22355501)
2011
22
I^-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. (21959308)
2011
23
Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review. (21813397)
2011
24
Narrow-band imaging of interdigitating dendritic cell sarcoma originating in the duodenum. (21425001)
2011
25
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
26
Follicular dendritic cell sarcoma of the abdomen: the imaging findings. (20191073)
2010
27
Follicular dendritic cell sarcoma of small intestine with aberrant T-cell marker expression. (19883432)
2009
28
SIR 2008 annual meeting film panel case: Castleman disease complicated by follicular dendritic cell sarcoma. (18656005)
2008
29
Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma. (18786443)
2008
30
Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. (18272816)
2008
31
Interdigitating dendritic cell sarcoma of the eyelid with a rapidly fatal course. (18474795)
2008
32
Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. (17721283)
2007
33
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
34
Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. (18194598)
2007
35
Interdigitating dendritic cell sarcoma of the parotid gland. (16372988)
2006
36
Interwoven dendritic processes of follicular dendritic cell sarcoma demonstrated on ultrafast papanicolaou-stained smears: a case report. (17017440)
2006
37
Clonal cytogenetic abnormalities and BCL2 rearrangement in interdigitating dendritic cell sarcoma. (17169812)
2006
38
Follicular dendritic cell sarcoma of lymph node--a rare entity. (16696516)
2006
39
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma and Castleman disease. (16029358)
2005
40
Interdigitating dendritic cell sarcoma/tumour of the tonsil. (16281930)
2005
41
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus. (16120143)
2005
42
Follicular dendritic cell sarcoma: case report and review of current management principles. (16343408)
2005
43
Paraneoplastic pemphigus revealing dendritic cell sarcoma originating from Castleman's disease of the neck]. (15746607)
2005
44
Mediastinal mixed dendritic cell sarcoma with hybrid features. (12354813)
2002
45
Follicular dendritic cell sarcoma of the neck; a case report and literature review. (12393051)
2002
46
Fine needle aspiration cytology of follicular dendritic cell sarcoma. Report of a case with cytologic detection in an extranodal site. (11015984)
2000
47
Extranodal follicular dendritic cell sarcoma of the palate. (10052377)
1999
48
Myxoid variant of follicular dendritic cell sarcoma arising in the breast. (10196389)
1999
49
Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. (9010103)
1997
50
Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma: a case report. (9256295)
1997

Variations for Dendritic Cell Sarcoma

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Expression for genes affiliated with Dendritic Cell Sarcoma

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Search GEO for disease gene expression data for Dendritic Cell Sarcoma.

Pathways for genes affiliated with Dendritic Cell Sarcoma

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Pathways related to Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.8CR2, CR1, CLU
29.7VIM, DSP, CLDN1
39.5FCER2, IL2RA, CR1, CR2
4
Show member pathways
9.5CR2, IL2RA, FCER2, TP53
59.4TP53, FCER2, VIM, CR2
6
Show member pathways
9.2DSP, DSG1, DSG3, VIM
79.2EVPL, VIM, DSP, PPL
8
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.9TP53, DSP, DSG1, DSG3, VIM

Compounds for genes affiliated with Dendritic Cell Sarcoma

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Compounds related to Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 44)
idCompoundScoreTop Affiliating Genes
1cr2+4310.4CR2, CR1
2mycophenolate sodium4310.3CR1, IL2RA
3okt34310.2FCER2, IL2RA, CR2
4tunicamycin43 5911.2SLC2A1, CLU, FCER2
5toxin a4310.1DSG1, DSG3
6asulam4310.1DSP, PPL
7cytochalasin b4310.1SLC2A1, VIM, FCER2
8aristolochic acid43 211.1VIM, TP53
9calcitriol43 59 24 1212.9FCER2, CLU, IL2RA, SLC2A1
10ivig439.9DSG1, DSG3, IL2RA
11mannose439.9FCER2, CR1, SLC2A1
12vincristine43 49 1211.9IL2RA, VIM, TP53
13cytarabine43 49 1211.9TP53, VIM, CR1
14formaldehyde43 2410.8CR1, IL2RA, VIM, FCER2
15folate439.8IL2RA, VIM, CLU
16temozolomide43 1210.8VIM, TP53
17vitamin d439.8CLU, VIM, IL2RA, CR1
18etoposide43 49 59 1212.7IL2RA, VIM, CLU, TP53
19prednisolone43 28 1211.7CR1, IL2RA, DSG3
20butyrate439.7TP53, CLU, VIM, SLC2A1
2112-o-tetradecanoylphorbol 13-acetate439.7FCER2, DSP, VIM, FSCN1
22lactate439.7FCER2, CLU, VIM, SLC2A1
23genistein43 28 59 2 24 1214.7FCER2, VIM, IL2RA, SLC2A1
24fmlp439.7FCER2, VIM, CR1
25actinomycin d439.7TP53, CLU, VIM, SLC2A1
26doxorubicin43 49 1211.7TP53, CLU, VIM, IL2RA
27thymidine43 2410.7TP53, FCER2, CLU, IL2RA
28dmso439.7CR1, VIM, DSP
295-aza-2deoxycytidine439.6TP53, CLU, VIM, SNCG
30cisplatin43 49 59 1212.6SLC2A1, IL2RA, CLU, TP53
31dexamethasone43 49 28 1212.6SLC2A1, IL2RA, VIM, CLU, FCER2
32acetylcholine43 49 28 24 1213.6IL2RA, VIM, DSG3, DSG1
33heparin43 28 24 1212.5CLU, VIM, IL2RA, CR1, SLC2A1
34vegf439.4TP53, CLU, VIM, IL2RA, SLC2A1
35paclitaxel43 49 1211.4TP53, CLU, VIM, IL2RA, SNCG
36atp43 2810.3FCER2, CLU, VIM, CR1, SLC2A1
37cycloheximide439.1TP53, FCER2, CLU, VIM, CR1, CR2
38cysteine438.9FCER2, CLU, VIM, IL2RA, SLC2A1
39estrogen438.9TP53, CLU, VIM, IL2RA, SNCG, CR2
40retinoic acid43 249.7TP53, FCER2, CLU, DSP, DSG1, VIM
41serine438.1TP53, FCER2, CLU, DSP, DSG1, DSG3
42tyrosine438.0DSG3, DSP, CLU, FCER2, FSCN1, IL2RA
43paraffin438.0SLC2A1, TP53, FCER2, CLU, VIM, FSCN1
44calcium43 49 24 1210.5DSP, CLU, CLDN1, FCER2, DSG1, DSG3

GO Terms for genes affiliated with Dendritic Cell Sarcoma

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Cellular components related to Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:000153310.0EVPL, DSP
2desmosomeGO:00300578.7PPL, DSP, DSG1, DSG3, EVPL
3extracellular vesicular exosomeGO:00700626.8SLC2A1, PPL, FCER2, CLU, DSP, DSG3
4plasma membraneGO:00058866.3PPL, FCER2, DSP, DSG1, DSG3, VIM

Biological processes related to Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:004510910.0DSP, VIM
2peptide cross-linkingGO:00181499.9DSP, EVPL
3release of cytochrome c from mitochondriaGO:00018369.9CLU, TP53
4complement activation, classical pathwayGO:00069589.9CR2, CR1, CLU
5cellular response to glucose starvationGO:00421499.9SLC2A1, TP53
6Notch signaling pathwayGO:00072199.8IL2RA, FCER2, TP53
7actin filament bundle assemblyGO:00510179.5FSCN1, FSCN2
8cellular component disassembly involved in execution phase of apoptosisGO:00069219.4VIM, DSG3, DSG1, DSP
9apoptotic processGO:00069158.8TP53, DSP, DSG1, DSG3, VIM, IL2RA

Molecular functions related to Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:00051989.8EVPL, DSP, CLDN1
2scaffold protein bindingGO:00971109.8VIM, DSP
3structural constituent of cytoskeletonGO:00052009.7PPL, DSP
4identical protein bindingGO:00428029.1TP53, CLDN1, VIM, SLC2A1
5actin filament bindingGO:00510159.0FSCN1, FSCN2, FSCN3
6protein binding, bridgingGO:00306748.6EVPL, FSCN1, FSCN2, FSCN3, DSP

Products for genes affiliated with Dendritic Cell Sarcoma

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Sources for Dendritic Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet