MCID: DND002
MIFTS: 43

Dendritic Cell Sarcoma malady

Cancer, Blood categories

Summaries for Dendritic Cell Sarcoma

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A histiocytic and dendritic cell cancer that is mainly located in lymph nodes.

MalaCards: Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, not otherwise specified, is related to follicular dendritic cell sarcoma and castleman's disease. An important gene associated with Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Immune response Lectin induced complement pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cycloheximide and cr2+ have been mentioned in the context of this disorder. Affiliated tissues include lymph nodes, and related mouse phenotypes are hematopoietic system and cellular.

Aliases & Classifications for Dendritic Cell Sarcoma

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT, 58SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Aliases & Descriptions:

dendritic cell sarcoma 8 10
dendritic cell sarcoma, not otherwise specified 8
dendritic cell sarcoma not otherwise specified 49
dendritic cell sarcoma, interdigitating 61


External Ids:

Disease Ontology8 DOID:7849
NCIt40 C27260
SNOMED-CT via Orphanet58 397355008
ICD10 via Orphanet26 C96.4
UMLS via Orphanet62 C1301364
ICD1025 C96.4

Related Diseases for Dendritic Cell Sarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1follicular dendritic cell sarcoma31.8PPL
2castleman's disease30.9DSG3, FSCN1
3pemphigus30.9PPL, DSP, DSG3, DSG1, EVPL
4follicular lymphoma30.5CR2, CR1, FCER2
5t-cell leukemia30.4SLC2A1, FCER2, IL2RA, CR2, TNFRSF8
6amyloidosis30.2CLU, SNCG
7thymoma30.2PPL, DSP, EVPL
8interdigitating dendritic cell sarcoma11.0
9paraneoplastic pemphigus10.6
10follicular dendritic cell tumor10.6
11small cell sarcoma10.5
12histiocytic sarcoma10.4
13langerhans cell sarcoma10.4
14thyroid sarcoma10.4
15vascular disease10.4
16pancreas sarcoma10.1
17cellulitis10.1
18liver inflammatory pseudotumor10.1
19bone lymphoma10.1
20bladder sarcoma10.1
21spindle cell sarcoma10.1
22kaposi's sarcoma10.1
23retroperitoneal leiomyosarcoma10.1
24kidney leiomyosarcoma10.1
25acute leukemia10.1
26bladder calculus10.1
27skin sarcoma10.1
28thyroiditis10.1
29uterine disease10.1
30acute myelomonocytic leukemia10.1
31leukemia, t-cell, chronic10.1
32uterine sarcoma10.1
33amyloidosis, secondary10.1
34leukemia/lymphoma, t-cell10.1
35lymphoma, diffuse large cell10.1
36indeterminate cell histiocytosis10.1
37bronchiolitis10.0FCER2
38pemphigus vegetans10.0DSG1
39atopic dermatitis10.0FCER2
40cystadenoma10.0CLU
41inverted papilloma10.0FSCN1
42keratoacanthoma10.0DSG3
43epidermolysis bullosa acquisita10.0DSG1
44bronchiolitis obliterans10.0PPL
45lichen planus10.0DSG3
46epidermolysis bullosa10.0DSP
47hailey-hailey disease10.0DSP
48bullous impetigo10.0DSG1
49mastocytosis10.0IL2RA
50subcorneal pustular dermatosis10.0DSG1

Graphical network of the top 20 diseases related to Dendritic Cell Sarcoma:



Diseases related to dendritic cell sarcoma

Clinical Features for Dendritic Cell Sarcoma

Drugs & Therapeutics for Dendritic Cell Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Dendritic Cell Sarcoma

Drug clinical trials:

Search ClinicalTrials for Dendritic Cell Sarcoma

Search NIH Clinical Center for Dendritic Cell Sarcoma

Search CenterWatch for Dendritic Cell Sarcoma

Genetic Tests for Dendritic Cell Sarcoma

Anatomical Context for Dendritic Cell Sarcoma

Sources:
14FMA
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FMA organs/tissues related to Dendritic Cell Sarcoma:

14
Lymph nodes

Animal Models for Dendritic Cell Sarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Dendritic Cell Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.5TNFRSF8, CR2, DSG3, CD68, CXCL13, IL2RA
2MP:00053846.9TP53, VIM, SLC2A1, FCER2, FSCN1, IL2RA
3MP:00053876.7CXCL13, FCER2, FSCN1, IL2RA, CLU, CD68

Publications for Dendritic Cell Sarcoma

Sources:
51PubMed
See all sources

Articles related to Dendritic Cell Sarcoma:

(show top 50)    (show all 211)
idTitleAuthorsYear
1
Optimized immunohistochemical panel to differentiate myeloid sarcoma from blastic plasmacytoid dendritic cell neoplasm. (24390220)
2014
2
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
3
Kaposi's-sarcoma-associated-herpesvirus-activated dendritic cells promote HIV-1 trans-infection and suppress CD4(+) T cell proliferation. (23510674)
2013
4
Langerhans/dendritic cell sarcoma arising from hairy cell leukemia: a rare phenomenon. (22234838)
2012
5
Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor. (22938549)
2012
6
Dendritic cell immunotherapy in soft tissue sarcoma. (23148754)
2012
7
Follicular dendritic cell sarcoma: a diagnostic challenge ! (22842383)
2012
8
Small intestine perforation due to metastatic uterine cervix interdigitating dendritic cell sarcoma: a rare manifestation of a rare disease. (22355501)
2011
9
Activation of plasmacytoid dendritic cells by Kaposi's sarcoma-associated herpesvirus. (20980519)
2011
10
Narrow-band imaging of interdigitating dendritic cell sarcoma originating in the duodenum. (21425001)
2011
11
Extranodal interdigitating dendritic cell sarcoma presenting in the pleura: a case report. (21286027)
2011
12
Cervical follicular dendritic cell sarcoma: a case report and review of the literature. (21658332)
2011
13
Interdigitating dendritic cell sarcoma of lymph node mimicking granuloma: a case report and review of the literature. (22246915)
2011
14
Primary follicular dendritic cell sarcoma of liver treated with cyclophosphamide, doxorubicin, vincristine, and prednisone regimen and surgery. (22042944)
2011
15
Detection of SRS19-6MuLV in mouse dendritic cell sarcoma and its tumorigenesis. (21643628)
2011
16
Follicular dendritic cell sarcoma and associated myasthenia gravis: true, true, related? (21321294)
2011
17
The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. (20656318)
2010
18
Follicular dendritic cell sarcoma with immature T-cell proliferation. (19740517)
2010
19
Extranodal follicular dendritic cell sarcoma of the pharyngeal region: a potential diagnostic pitfall, with literature review. (20023258)
2010
20
Follicular dendritic cell sarcoma: a case report and review of the literature. (20622968)
2010
21
Clinical and pathological features of follicular dendritic cell sarcoma of appendix: a case report. (19719956)
2009
22
Interdigitating dendritic cell sarcoma of the leg. (19521127)
2009
23
Interdigitating dendritic cell sarcoma of the parotid gland: case report and literature review. (19563939)
2009
24
SIR 2008 annual meeting film panel case: Castleman disease complicated by follicular dendritic cell sarcoma. (18656005)
2008
25
Follicular dendritic cell sarcoma of the nasopharynx. (18598838)
2008
26
Follicular dendritic cell sarcoma of the neck: report of a case treated by surgical excision and COP plus (PEG)-liposomal doxorubicin. (18761751)
2008
27
Expression of Glut-1 and Claudin-1 in follicular dendritic cell sarcoma. (18227718)
2008
28
Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. (18194598)
2007
29
Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature. (17373675)
2007
30
Follicular dendritic cell sarcoma in the lymph nodes of the neck. (18203543)
2007
31
Interdigitating dendritic cell sarcoma of the parotid gland. (16372988)
2006
32
Clonal cytogenetic abnormalities and BCL2 rearrangement in interdigitating dendritic cell sarcoma. (17169812)
2006
33
Follicular dendritic cell sarcoma of lymph node--a rare entity. (16696516)
2006
34
Nodal follicular dendritic cell sarcoma of the axilla presenting as cellulitis. (16403115)
2006
35
Follicular dendritic cell sarcoma mimicking giant cell carcinoma of the pancreas. (16872443)
2006
36
Interdigitating dendritic cell sarcoma of the duodenum with rapidly fatal course: a case report and review of the literature. (16454564)
2006
37
Synchronous interdigitating dendritic cell sarcoma and B-cell small lymphocytic lymphoma in a lymph node. (16594749)
2006
38
Fine-needle aspiration cytology of a liver metastasis of follicular dendritic cell sarcoma. (15584048)
2005
39
Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection. (14693845)
2004
40
Follicular dendritic cell sarcoma of a cervical lymph node: case report and review of the literature. (15724745)
2004
41
Two cases of extranodal follicular dendritic cell sarcoma. (12875705)
2003
42
Immunotherapy with autologous dendritic cells and tumor-specific synthetic peptides for synovial sarcoma. (11990310)
2002
43
Follicular dendritic cell sarcoma of the neck; a case report and literature review. (12393051)
2002
44
Interdigitating dendritic cell sarcoma of the spleen: report of a case with a review of the literature. (11914634)
2002
45
Interdigitating dendritic cell sarcoma: a rare malignancy responsive to ABVD chemotherapy. (12153170)
2002
46
Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman's disease of the nasopharynx: tracing its evolution by sequential biopsies. (11422494)
2001
47
Retroperitoneal follicular dendritic cell sarcoma presenting as secondary amyloidosis. (11436023)
2001
48
Follicular dendritic cell sarcoma: ultrastructural and immunohistochemical studies. (11065250)
2000
49
Follicular dendritic cell sarcoma presenting as a submucosal tumor of the stomach. (11079028)
2000
50
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma arising from Castleman's tumor. (10025851)
1999

Genetic Variations for Dendritic Cell Sarcoma

Expression for genes affiliated with Dendritic Cell Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dendritic Cell Sarcoma

Search GEO for disease gene expression data for Dendritic Cell Sarcoma.

Pathways for genes affiliated with Dendritic Cell Sarcoma

Sources:
12EMD Millipore, 54Reactome, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Dendritic Cell Sarcoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 29IUPHAR
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Compounds related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.6CR1
2cr2+4510.4CR2, CR1
3mycophenolate sodium4510.3CR1, IL2RA
4asulam4510.3PPL, DSP
5okt34510.2FCER2, IL2RA, CR2
6cytochalasin b4510.1VIM, FCER2, SLC2A1
7ricin a4510.0TNFRSF8, IL2RA
8paclitaxel45 50 1112.0TP53, CLU, SNCG
9tunicamycin45 6011.0CLU, FCER2, SLC2A1
10toxin a459.9DSG1, DSG3
11ivig459.9IL2RA, DSG1, DSG3
12calcitriol45 60 11 2412.9SLC2A1, FCER2, IL2RA, CLU
13formaldehyde45 2410.9VIM, CR1, IL2RA, FCER2
14heparin45 29 11 2412.8SLC2A1, IL2RA, CLU, CR1
155-aza-2deoxycytidine459.7TP53, CLU, SNCG, VIM
16cytarabine45 50 1111.7TP53, CR1, VIM
17etoposide45 50 60 1112.7TP53, IL2RA, CLU, VIM
1812-o-tetradecanoylphorbol 13-acetate459.6VIM, DSP, FSCN1, FCER2
19vitamin d459.5VIM, CR1, CLU, IL2RA
20thymidine45 2410.4TNFRSF8, CLU, IL2RA, FCER2, TP53
21serine459.2DSP, DSG3, DSG1, CLU, FSCN1, FCER2
22acetylcholine45 50 29 11 2413.2IL2RA, DSG1, DSG3, VIM
23estrogen459.1VIM, CR2, SNCG, CLU, IL2RA, SLC2A1
24retinoic acid45 2410.0VIM, CR1, DSP, DSG1, CLU, FSCN1
25tyrosine458.0TNFRSF8, CR2, CR1, SNCG, DSP, DSG3
26paraffin457.8TP53, VIM, TNFRSF8, CR2, CR1, CD68
27calcium45 50 11 2410.7DSP, SNCG, CR1, CR2, TNFRSF8, DSG3

GO Terms for genes affiliated with Dendritic Cell Sarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300578.9EVPL, DSG1, DSG3, DSP, PPL
2plasma membraneGO:0058866.8SNCG, CR1, CR2, PPL, TNFRSF8, DSP

Biological processes related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activation, classical pathwayGO:0069589.9CLU, CR1, CR2
2intermediate filament organizationGO:0451099.9DSP, VIM
3cellular response to glucose starvationGO:0421499.7SLC2A1, TP53
4cellular component disassembly involved in execution phase of apoptosisGO:0069219.6DSG1, DSG3, DSP, VIM
5positive regulation of apoptotic processGO:0430659.3TNFRSF8, CLU, IL2RA, TP53
6apoptotic processGO:0069159.2IL2RA, DSG1, DSG3, DSP, VIM

Molecular functions related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.7DSP, PPL, VIM
2protein binding, bridgingGO:0306749.5EVPL, FSCN1, DSP

Products for genes affiliated with Dendritic Cell Sarcoma

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Sources for Dendritic Cell Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet