MCID: DND002
MIFTS: 56

Dendritic Cell Sarcoma malady

Cancer diseases, Blood diseases, Rare diseases categories

Summaries for Dendritic Cell Sarcoma

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A histiocytic and dendritic cell cancer that is mainly located in lymph nodes.

MalaCards: Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, not otherwise specified, is related to follicular dendritic cell sarcoma and sarcoma. An important gene associated with Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Complement Pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cr2+ and mycophenolate sodium have been mentioned in the context of this disorder. Affiliated tissues include lymph nodes, lymph node and tonsil, and related mouse phenotypes are mortality/aging and hematopoietic system.

Aliases & Classifications for Dendritic Cell Sarcoma

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9Disease Ontology, 11DISEASES, 50Orphanet, 63UMLS, 59SNOMED-CT, 41NCIt, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

dendritic cell sarcoma 9 11
dendritic cell sarcoma, not otherwise specified 9
dendritic cell sarcoma not otherwise specified 50
dendritic cell sarcoma, interdigitating 63


External Ids:

Disease Ontology9 DOID:7849
NCIt41 C27260
SNOMED-CT via Orphanet60 397355008
ICD10 via Orphanet27 C96.4
UMLS via Orphanet64 C1301364
ICD1026 C96.4

Related Diseases for Dendritic Cell Sarcoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1follicular dendritic cell sarcoma32.0PPL
2sarcoma31.7PPL, EVPL, CR2, FSCN1, VIM, DSG1
3castleman's disease31.0FSCN1, DSG3
4pemphigus31.0PPL, DSP, DSG1, DSG3, EVPL
5leukemia30.6TP53, FCER2, IL2RA, CR1, CR2, EVPL
6histiocytosis30.5FSCN1, CD68
7follicular lymphoma30.5CR2, CR1, FCER2
8chronic lymphocytic leukemia30.5FCER2, IL2RA, CR1, CR2
9thymoma30.3PPL, DSP, EVPL
10leiomyosarcoma30.2TP53, VIM, CR2
11interdigitating dendritic cell sarcoma11.0
12tonsillitis10.7
13paraneoplastic pemphigus10.6
14mediastinitis10.4
15pharyngitis10.4
16cervicitis10.4
17myasthenia gravis10.4
18thyroiditis10.4
19hairy cell leukemia10.3
20hepatitis10.3
21langerhans-cell histiocytosis10.1
22retroperitoneal leiomyosarcoma10.1
23nasopharyngitis10.1
24amyloidosis10.1
25cellulitis10.1
26intestinal perforation10.1
27acute myelomonocytic leukemia10.1
28follicular dendritic cell tumor10.1
29indeterminate cell histiocytosis10.1
30histiocytic sarcoma10.1
31nonepidermolytic palmoplantar keratoderma10.1EVPL
32pemphigus vegetans10.1DSG1
33hailey-hailey disease10.1DSP
34bullous impetigo10.1DSG1
35subcorneal pustular dermatosis10.1DSG1
36choroid plexus papilloma10.1TP53
37epidermolysis bullosa acquisita10.1DSG1
38pemphigus erythematosus10.1DSG3, DSP
39bullous skin disease10.1DSG1, DSG3, EVPL
40keratoderma10.1DSG1, DSP
41bullous pemphigoid10.1EVPL, DSP, PPL
42keratosis10.1DSP
43palmoplantar keratosis10.1DSP, DSG1
44fibrous histiocytoma10.1VIM, FSCN1
45anaplastic large cell lymphoma10.1IL2RA, FSCN1, CLU
46pemphigus foliaceus10.1PPL, DSG1, DSG3, EVPL
47allergic asthma10.1CR2, IL2RA, FCER2
48burkitt's lymphoma10.1CR2, CXCL13, FCER2
49reticulosarcoma10.1CLU, FSCN1, CD68
50skin disease10.0DSG3, DSG1, DSP, FCER2

Graphical network of the top 20 diseases related to Dendritic Cell Sarcoma:



Diseases related to dendritic cell sarcoma

Symptoms for Dendritic Cell Sarcoma

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Drugs & Therapeutics for Dendritic Cell Sarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Dendritic Cell Sarcoma

Drug clinical trials:

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Search NIH Clinical Center for Dendritic Cell Sarcoma

Search CenterWatch for Dendritic Cell Sarcoma

Genetic Tests for Dendritic Cell Sarcoma

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Anatomical Context for Dendritic Cell Sarcoma

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Dendritic Cell Sarcoma:

34
Lymph node, Tonsil, Liver, Bone, Spleen, T cells, Thyroid, Lung, Bone marrow, Breast, Small intestine, Cervix, Salivary gland, Pancreas, B cells, Skin, Colon, Kidney, Appendix

FMA organs/tissues related to Dendritic Cell Sarcoma:

15
Lymph nodes

Animal Models for Dendritic Cell Sarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Dendritic Cell Sarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0FCER2, CLDN1, DSP, DSG3, VIM, IL2RA
2MP:00053977.3TP53, FCER2, DSG3, VIM, CXCL13, IL2RA
3MP:00053847.2TP53, FCER2, DSP, DSG3, VIM, FSCN1
4MP:00053877.0CD68, TP53, FCER2, CLU, DSG3, VIM

Publications for Dendritic Cell Sarcoma

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53PubMed
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Articles related to Dendritic Cell Sarcoma:

(show top 50)    (show all 192)
idTitleAuthorsYear
1
Interdigitating dendritic cell sarcoma presenting in the kidney combined with retroperitoneal leiomyosarcoma: A case report and literature review. (24396471)
2014
2
The genetics of interdigitating dendritic cell sarcoma share some changes with Langerhans cell histiocytosis in select cases. (24321462)
2014
3
Regulation of the exopolysaccharide from an anamorph of Cordyceps sinensis on dendritic cell sarcoma (DCS) cell line. (22610670)
2013
4
Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of six cases with increased IgG4-positive plasma cells. (23714251)
2013
5
A rare case of follicular dendritic cell sarcoma involving multiple bones. (23640234)
2013
6
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
7
Interdigitating dendritic cell sarcoma complicated with paraneoplastic pemphigus after surgery of resection. (23652075)
2013
8
Interdigitating dendritic cell sarcoma presenting simultaneously with acute myelomonocytic leukemia: report of a rare case and literature review. (23605368)
2013
9
Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. (23755890)
2013
10
Killing two birds with one stone: BRAF V600E inhibitor therapy for hairy cell leukemia and Langerhans/dendritic cell sarcoma. (23322213)
2013
11
Interdigitating dendritic cell sarcoma occured alone in axilla. (22563543)
2012
12
Pathology quiz case 1. Follicular dendritic cell sarcoma (FDS). (22801898)
2012
13
Extranodal follicular dendritic cell sarcoma with rapid growth in parapharynx: a case report. (23110021)
2012
14
Computed tomography and 18F-fluoro-2-deoxyglucose positron emission tomography findings of primary pulmonary follicular dendritic cell sarcoma: case report and a literature review. (21795995)
2012
15
Langerhans/dendritic cell sarcoma arising from hairy cell leukemia: a rare phenomenon. (22234838)
2012
16
Small intestine perforation due to metastatic uterine cervix interdigitating dendritic cell sarcoma: a rare manifestation of a rare disease. (22355501)
2011
17
I^-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. (21959308)
2011
18
Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review. (21813397)
2011
19
Narrow-band imaging of interdigitating dendritic cell sarcoma originating in the duodenum. (21425001)
2011
20
Extranodal interdigitating dendritic cell sarcoma presenting in the pleura: a case report. (21286027)
2011
21
Follicular dendritic cell sarcoma of the lung: a report of two cases highlighting its pathological features and diagnostic pitfalls. (21240069)
2011
22
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
23
Follicular dendritic cell sarcoma of the abdomen: the imaging findings. (20191073)
2010
24
Follicular dendritic cell sarcoma of small intestine with aberrant T-cell marker expression. (19883432)
2009
25
Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro. (19432677)
2009
26
SIR 2008 annual meeting film panel case: Castleman disease complicated by follicular dendritic cell sarcoma. (18656005)
2008
27
Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma. (18786443)
2008
28
Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. (18272816)
2008
29
Interdigitating dendritic cell sarcoma of the eyelid with a rapidly fatal course. (18474795)
2008
30
Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. (17721283)
2007
31
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
32
Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. (18194598)
2007
33
Interdigitating dendritic cell sarcoma of the parotid gland. (16372988)
2006
34
Interwoven dendritic processes of follicular dendritic cell sarcoma demonstrated on ultrafast papanicolaou-stained smears: a case report. (17017440)
2006
35
Clonal cytogenetic abnormalities and BCL2 rearrangement in interdigitating dendritic cell sarcoma. (17169812)
2006
36
Follicular dendritic cell sarcoma of lymph node--a rare entity. (16696516)
2006
37
Nodal follicular dendritic cell sarcoma of the axilla presenting as cellulitis. (16403115)
2006
38
Follicular dendritic cell sarcoma mimicking giant cell carcinoma of the pancreas. (16872443)
2006
39
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma and Castleman disease. (16029358)
2005
40
Interdigitating dendritic cell sarcoma/tumour of the tonsil. (16281930)
2005
41
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus. (16120143)
2005
42
Follicular dendritic cell sarcoma: case report and review of current management principles. (16343408)
2005
43
Paraneoplastic pemphigus revealing dendritic cell sarcoma originating from Castleman's disease of the neck]. (15746607)
2005
44
Mediastinal mixed dendritic cell sarcoma with hybrid features. (12354813)
2002
45
Follicular dendritic cell sarcoma of the neck; a case report and literature review. (12393051)
2002
46
Fine needle aspiration cytology of follicular dendritic cell sarcoma. Report of a case with cytologic detection in an extranodal site. (11015984)
2000
47
Extranodal follicular dendritic cell sarcoma of the palate. (10052377)
1999
48
Myxoid variant of follicular dendritic cell sarcoma arising in the breast. (10196389)
1999
49
Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. (9010103)
1997
50
Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma: a case report. (9256295)
1997

Variations for Dendritic Cell Sarcoma

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Expression for genes affiliated with Dendritic Cell Sarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dendritic Cell Sarcoma

Search GEO for disease gene expression data for Dendritic Cell Sarcoma.

Pathways for genes affiliated with Dendritic Cell Sarcoma

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Sources:
51PathCards, 54QIAGEN, 61Thomson Reuters, 56Reactome, 58SinoBiological, 31KEGG, 39NCBI BioSystems Database
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Pathways related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.8CR2, CR1, CLU
29.7VIM, DSP, CLDN1
39.5FCER2, IL2RA, CR1, CR2
4
Show member pathways
9.5CR2, IL2RA, FCER2, TP53
59.4TP53, FCER2, VIM, CR2
6
Show member pathways
9.2DSP, DSG1, DSG3, VIM
79.2EVPL, VIM, DSP, PPL
8
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
8.9TP53, DSP, DSG1, DSG3, VIM

Compounds for genes affiliated with Dendritic Cell Sarcoma

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Sources:
46Novoseek, 62Tocris Bioscience, 3BitterDB, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR
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Compounds related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1cr2+4610.4CR2, CR1
2mycophenolate sodium4610.3CR1, IL2RA
3okt34610.2FCER2, IL2RA, CR2
4tunicamycin46 6211.2SLC2A1, CLU, FCER2
5toxin a4610.1DSG1, DSG3
6asulam4610.1DSP, PPL
7cytochalasin b4610.1SLC2A1, VIM, FCER2
8aristolochic acid46 311.1VIM, TP53
9calcitriol46 62 25 1212.9FCER2, CLU, IL2RA, SLC2A1
10ivig469.9DSG1, DSG3, IL2RA
11mannose469.9FCER2, CR1, SLC2A1
12vincristine46 52 1211.9IL2RA, VIM, TP53
13cytarabine46 52 1211.9TP53, VIM, CR1
14formaldehyde46 2510.8CR1, IL2RA, VIM, FCER2
15folate469.8IL2RA, VIM, CLU
16temozolomide46 1210.8VIM, TP53
17vitamin d469.8CLU, VIM, IL2RA, CR1
18etoposide46 52 62 1212.7IL2RA, VIM, CLU, TP53
19prednisolone46 30 1211.7CR1, IL2RA, DSG3
20butyrate469.7TP53, CLU, VIM, SLC2A1
2112-o-tetradecanoylphorbol 13-acetate469.7FCER2, DSP, VIM, FSCN1
22lactate469.7FCER2, CLU, VIM, SLC2A1
23genistein46 30 62 3 25 1214.7FCER2, VIM, IL2RA, SLC2A1
24fmlp469.7FCER2, VIM, CR1
25actinomycin d469.7TP53, CLU, VIM, SLC2A1
26doxorubicin46 52 1211.7TP53, CLU, VIM, IL2RA
27thymidine46 2510.7TP53, FCER2, CLU, IL2RA
28dmso469.7CR1, VIM, DSP
295-aza-2deoxycytidine469.6TP53, CLU, VIM, SNCG
30cisplatin46 52 62 1212.6SLC2A1, IL2RA, CLU, TP53
31dexamethasone46 52 30 1212.6SLC2A1, IL2RA, VIM, CLU, FCER2
32acetylcholine46 52 30 25 1213.6IL2RA, VIM, DSG3, DSG1
33heparin46 30 25 1212.5CLU, VIM, IL2RA, CR1, SLC2A1
34vegf469.4TP53, CLU, VIM, IL2RA, SLC2A1
35paclitaxel46 52 1211.4TP53, CLU, VIM, IL2RA, SNCG
36atp46 3010.3FCER2, CLU, VIM, CR1, SLC2A1
37cycloheximide469.1TP53, FCER2, CLU, VIM, CR1, CR2
38cysteine468.9FCER2, CLU, VIM, IL2RA, SLC2A1
39estrogen468.9TP53, CLU, VIM, IL2RA, SNCG, CR2
40retinoic acid46 259.7TP53, FCER2, CLU, DSP, DSG1, VIM
41serine468.1TP53, FCER2, CLU, DSP, DSG1, DSG3
42tyrosine468.0DSG3, DSP, CLU, FCER2, FSCN1, IL2RA
43paraffin468.0SLC2A1, TP53, FCER2, CLU, VIM, FSCN1
44calcium46 52 25 1210.5DSP, CLU, CLDN1, FCER2, DSG1, DSG3

GO Terms for genes affiliated with Dendritic Cell Sarcoma

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17Gene Ontology
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Cellular components related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:00153310.0EVPL, DSP
2desmosomeGO:0300578.7PPL, DSP, DSG1, DSG3, EVPL
3extracellular vesicular exosomeGO:0700626.8SLC2A1, PPL, FCER2, CLU, DSP, DSG3
4plasma membraneGO:0058866.3PPL, FCER2, DSP, DSG1, DSG3, VIM

Biological processes related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:04510910.0DSP, VIM
2peptide cross-linkingGO:0181499.9DSP, EVPL
3release of cytochrome c from mitochondriaGO:0018369.9CLU, TP53
4complement activation, classical pathwayGO:0069589.9CR2, CR1, CLU
5cellular response to glucose starvationGO:0421499.9SLC2A1, TP53
6Notch signaling pathwayGO:0072199.8IL2RA, FCER2, TP53
7actin filament bundle assemblyGO:0510179.5FSCN1, FSCN2
8cellular component disassembly involved in execution phase of apoptosisGO:0069219.4VIM, DSG3, DSG1, DSP
9apoptotic processGO:0069158.8TP53, DSP, DSG1, DSG3, VIM, IL2RA

Molecular functions related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051989.8EVPL, DSP, CLDN1
2scaffold protein bindingGO:0971109.8VIM, DSP
3structural constituent of cytoskeletonGO:0052009.7PPL, DSP
4identical protein bindingGO:0428029.1TP53, CLDN1, VIM, SLC2A1
5actin filament bindingGO:0510159.0FSCN1, FSCN2, FSCN3
6protein binding, bridgingGO:0306748.6EVPL, FSCN1, FSCN2, FSCN3, DSP

Products for genes affiliated with Dendritic Cell Sarcoma

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  • Antibodies
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Sources for Dendritic Cell Sarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet