MCID: DND002
MIFTS: 56

Dendritic Cell Sarcoma malady

Cancer diseases, Blood diseases, Rare diseases categories
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Summaries for Dendritic Cell Sarcoma

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Disease Ontology:8 A histiocytic and dendritic cell cancer that is mainly located in lymph nodes.

MalaCards based summary: Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, not otherwise specified, is related to follicular dendritic cell sarcoma and castleman's disease. An important gene associated with Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Complement Pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cr2+ and mycophenolate sodium have been mentioned in the context of this disorder. Affiliated tissues include lymph nodes, lymph node and tonsil, and related mouse phenotypes are mortality/aging and hematopoietic system.

Aliases & Classifications for Dendritic Cell Sarcoma

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Dendritic Cell Sarcoma, Aliases & Descriptions:

Name: Dendritic Cell Sarcoma 8 10
Dendritic Cell Sarcoma, Not Otherwise Specified 8
 
Dendritic Cell Sarcoma Not Otherwise Specified 48
Dendritic Cell Sarcoma, Interdigitating 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


External Ids:

Disease Ontology8 DOID:7849
NCIt39 C27260
ICD10 via Orphanet26 C96.4
UMLS via Orphanet63 C1301364
ICD1025 C96.4

Related Diseases for Dendritic Cell Sarcoma

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Diseases related to Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1follicular dendritic cell sarcoma32.7PPL
2castleman's disease31.6DSG3, FSCN1
3pemphigus31.3EVPL, DSG1, DSG3, PPL, DSP
4sarcoma31.1CR2, FSCN1, VIM, DSG1, DSP, CLU
5follicular lymphoma30.8CR1, CR2, FCER2
6thymoma30.7PPL, EVPL, DSP
7langerhans-cell histiocytosis30.6CD68, FSCN1
8chronic lymphocytic leukemia30.6CR1, FCER2, CR2, IL2RA
9leukemia30.4TP53, FCER2, IL2RA, CR1, EVPL, CR2
10leiomyosarcoma30.4CR2, TP53, VIM
11histiocytosis30.0FSCN1, FSCN3, FSCN2, CD68
12interdigitating dendritic cell sarcoma11.0
13paraneoplastic pemphigus10.7
14tonsillitis10.7
15nonepidermolytic palmoplantar keratoderma10.6EVPL
16pemphigus vegetans10.5DSG1
17mediastinitis10.5
18hailey-hailey disease10.5DSP
19bullous impetigo10.5DSG1
20subcorneal pustular dermatosis10.5DSG1
21thyroiditis10.4
22choroid plexus papilloma10.4TP53
23epidermolysis bullosa acquisita10.4DSG1
24pemphigus erythematosus10.4DSG3, DSP
25myasthenia gravis10.4
26pharyngitis10.4
27cervicitis10.4
28bullous skin disease10.4DSG3, DSG1, EVPL
29keratoderma10.4DSG1, DSP
30bullous pemphigoid10.3EVPL, PPL, DSP
31keratosis10.3DSP
32palmoplantar keratosis10.3DSG1, DSP
33hepatitis10.3
34hairy cell leukemia10.3
35fibrous histiocytoma10.3VIM, FSCN1
36anaplastic large cell lymphoma10.3CLU, FSCN1, IL2RA
37pemphigus foliaceus10.2DSG1, PPL, DSG3, EVPL
38allergic asthma10.2CR2, IL2RA, FCER2
39burkitt's lymphoma10.2CXCL13, CR2, FCER2
40reticulosarcoma10.2FSCN1, CD68, CLU
41skin disease10.2FCER2, DSG3, DSP, DSG1
42non-hodgkin lymphoma10.2CR2, IL2RA, FSCN1, FCER2
43membranous glomerulonephritis10.2CLU, CR1
44esophageal cancer10.2DSG1, TP53, FSCN1
45sarcoidosis10.2IL2RA, CR1, FCER2
46granular cell tumor10.2VIM, CD68
47bladder transitional cell carcinoma10.2TP53, SLC2A1
48retroperitoneal leiomyosarcoma10.1
49nasopharyngitis10.1
50amyloidosis10.1

Graphical network of the top 20 diseases related to Dendritic Cell Sarcoma:



Diseases related to dendritic cell sarcoma

Symptoms for Dendritic Cell Sarcoma

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Drugs & Therapeutics for Dendritic Cell Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Dendritic Cell Sarcoma

Search NIH Clinical Center for Dendritic Cell Sarcoma

Genetic Tests for Dendritic Cell Sarcoma

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Anatomical Context for Dendritic Cell Sarcoma

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MalaCards organs/tissues related to Dendritic Cell Sarcoma:

32
Lymph node, Tonsil, Liver, Bone, Spleen, Thyroid, Lung, T cells, Bone marrow, Small intestine, Colon, Breast, Kidney, Pancreas, Salivary gland, Skin, Cervix, B cells, Appendix

FMA organs/tissues related to Dendritic Cell Sarcoma:

14
Lymph nodes

Animal Models for Dendritic Cell Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Dendritic Cell Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0FCER2, CLDN1, DSP, DSG3, VIM, IL2RA
2MP:00053977.3TP53, FCER2, DSG3, VIM, CXCL13, IL2RA
3MP:00053847.2TP53, FCER2, DSP, DSG3, VIM, FSCN1
4MP:00053877.0CD68, TP53, FCER2, CLU, DSG3, VIM

Publications for Dendritic Cell Sarcoma

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Articles related to Dendritic Cell Sarcoma:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Paraneoplastic pemphigus associated with primary pulmonar follicular dendritic cell sarcoma showing good response to treatment. (25388966)
2014
2
Interdigitating dendritic cell sarcoma presenting in the kidney combined with retroperitoneal leiomyosarcoma: A case report and literature review. (24396471)
2014
3
The genetics of interdigitating dendritic cell sarcoma share some changes with Langerhans cell histiocytosis in select cases. (24321462)
2014
4
Regulation of the exopolysaccharide from an anamorph of Cordyceps sinensis on dendritic cell sarcoma (DCS) cell line. (22610670)
2013
5
Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of six cases with increased IgG4-positive plasma cells. (23714251)
2013
6
A rare case of follicular dendritic cell sarcoma involving multiple bones. (23640234)
2013
7
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
8
Interdigitating dendritic cell sarcoma complicated with paraneoplastic pemphigus after surgery of resection. (23652075)
2013
9
Interdigitating dendritic cell sarcoma presenting simultaneously with acute myelomonocytic leukemia: report of a rare case and literature review. (23605368)
2013
10
Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. (23755890)
2013
11
Killing two birds with one stone: BRAF V600E inhibitor therapy for hairy cell leukemia and Langerhans/dendritic cell sarcoma. (23322213)
2013
12
Interdigitating dendritic cell sarcoma occured alone in axilla. (22563543)
2012
13
Pathology quiz case 1. Follicular dendritic cell sarcoma (FDS). (22801898)
2012
14
Extranodal follicular dendritic cell sarcoma with rapid growth in parapharynx: a case report. (23110021)
2012
15
Computed tomography and 18F-fluoro-2-deoxyglucose positron emission tomography findings of primary pulmonary follicular dendritic cell sarcoma: case report and a literature review. (21795995)
2012
16
Langerhans/dendritic cell sarcoma arising from hairy cell leukemia: a rare phenomenon. (22234838)
2012
17
Small intestine perforation due to metastatic uterine cervix interdigitating dendritic cell sarcoma: a rare manifestation of a rare disease. (22355501)
2011
18
I^-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. (21959308)
2011
19
Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review. (21813397)
2011
20
Narrow-band imaging of interdigitating dendritic cell sarcoma originating in the duodenum. (21425001)
2011
21
Extranodal interdigitating dendritic cell sarcoma presenting in the pleura: a case report. (21286027)
2011
22
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
23
Follicular dendritic cell sarcoma of the abdomen: the imaging findings. (20191073)
2010
24
Follicular dendritic cell sarcoma of small intestine with aberrant T-cell marker expression. (19883432)
2009
25
Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro. (19432677)
2009
26
SIR 2008 annual meeting film panel case: Castleman disease complicated by follicular dendritic cell sarcoma. (18656005)
2008
27
Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma. (18786443)
2008
28
Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. (18272816)
2008
29
Interdigitating dendritic cell sarcoma of the eyelid with a rapidly fatal course. (18474795)
2008
30
Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. (17721283)
2007
31
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
32
Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. (18194598)
2007
33
Interdigitating dendritic cell sarcoma of the parotid gland. (16372988)
2006
34
Interwoven dendritic processes of follicular dendritic cell sarcoma demonstrated on ultrafast papanicolaou-stained smears: a case report. (17017440)
2006
35
Clonal cytogenetic abnormalities and BCL2 rearrangement in interdigitating dendritic cell sarcoma. (17169812)
2006
36
Follicular dendritic cell sarcoma of lymph node--a rare entity. (16696516)
2006
37
Nodal follicular dendritic cell sarcoma of the axilla presenting as cellulitis. (16403115)
2006
38
Follicular dendritic cell sarcoma mimicking giant cell carcinoma of the pancreas. (16872443)
2006
39
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma and Castleman disease. (16029358)
2005
40
Interdigitating dendritic cell sarcoma/tumour of the tonsil. (16281930)
2005
41
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus. (16120143)
2005
42
Follicular dendritic cell sarcoma: case report and review of current management principles. (16343408)
2005
43
Paraneoplastic pemphigus revealing dendritic cell sarcoma originating from Castleman's disease of the neck]. (15746607)
2005
44
Mediastinal mixed dendritic cell sarcoma with hybrid features. (12354813)
2002
45
Follicular dendritic cell sarcoma of the neck; a case report and literature review. (12393051)
2002
46
Fine needle aspiration cytology of follicular dendritic cell sarcoma. Report of a case with cytologic detection in an extranodal site. (11015984)
2000
47
Extranodal follicular dendritic cell sarcoma of the palate. (10052377)
1999
48
Myxoid variant of follicular dendritic cell sarcoma arising in the breast. (10196389)
1999
49
Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. (9010103)
1997
50
Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma: a case report. (9256295)
1997

Variations for Dendritic Cell Sarcoma

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Expression for genes affiliated with Dendritic Cell Sarcoma

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Expression patterns in normal tissues for genes affiliated with Dendritic Cell Sarcoma

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Pathways for genes affiliated with Dendritic Cell Sarcoma

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Pathways related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.8CR2, CR1, CLU
29.7VIM, DSP, CLDN1
39.5FCER2, IL2RA, CR1, CR2
4
Show member pathways
9.5CR2, IL2RA, FCER2, TP53
59.4TP53, FCER2, VIM, CR2
6
Show member pathways
9.2DSP, DSG1, DSG3, VIM
79.2EVPL, VIM, DSP, PPL
8
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.9TP53, DSP, DSG1, DSG3, VIM

Compounds for genes affiliated with Dendritic Cell Sarcoma

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Compounds related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1cr2+4410.4CR2, CR1
2mycophenolate sodium4410.3CR1, IL2RA
3okt34410.2FCER2, IL2RA, CR2
4tunicamycin44 6111.2SLC2A1, CLU, FCER2
5toxin a4410.1DSG1, DSG3
6asulam4410.1DSP, PPL
7cytochalasin b4410.1SLC2A1, VIM, FCER2
8aristolochic acid44 211.1VIM, TP53
9calcitriol44 61 24 1112.9FCER2, CLU, IL2RA, SLC2A1
10ivig449.9DSG1, DSG3, IL2RA
11mannose449.9FCER2, CR1, SLC2A1
12vincristine44 50 1111.9IL2RA, VIM, TP53
13cytarabine44 50 1111.9TP53, VIM, CR1
14formaldehyde44 2410.8CR1, IL2RA, VIM, FCER2
15folate449.8IL2RA, VIM, CLU
16temozolomide44 1110.8VIM, TP53
17vitamin d449.8CLU, VIM, IL2RA, CR1
18etoposide44 50 61 1112.7IL2RA, VIM, CLU, TP53
19prednisolone44 28 1111.7CR1, IL2RA, DSG3
20butyrate449.7TP53, CLU, VIM, SLC2A1
2112-o-tetradecanoylphorbol 13-acetate449.7FCER2, DSP, VIM, FSCN1
22lactate449.7FCER2, CLU, VIM, SLC2A1
23genistein44 28 61 2 24 1114.7FCER2, VIM, IL2RA, SLC2A1
24fmlp449.7FCER2, VIM, CR1
25actinomycin d449.7TP53, CLU, VIM, SLC2A1
26doxorubicin44 50 1111.7TP53, CLU, VIM, IL2RA
27thymidine44 2410.7TP53, FCER2, CLU, IL2RA
28dmso449.7CR1, VIM, DSP
295-aza-2deoxycytidine449.6TP53, CLU, VIM, SNCG
30cisplatin44 50 61 1112.6SLC2A1, IL2RA, CLU, TP53
31dexamethasone44 50 28 1112.6SLC2A1, IL2RA, VIM, CLU, FCER2
32acetylcholine44 50 28 24 1113.6IL2RA, VIM, DSG3, DSG1
33heparin44 28 24 1112.5CLU, VIM, IL2RA, CR1, SLC2A1
34vegf449.4TP53, CLU, VIM, IL2RA, SLC2A1
35paclitaxel44 50 1111.4TP53, CLU, VIM, IL2RA, SNCG
36atp44 2810.3FCER2, CLU, VIM, CR1, SLC2A1
37cycloheximide449.1TP53, FCER2, CLU, VIM, CR1, CR2
38cysteine448.9FCER2, CLU, VIM, IL2RA, SLC2A1
39estrogen448.9TP53, CLU, VIM, IL2RA, SNCG, CR2
40retinoic acid44 249.7TP53, FCER2, CLU, DSP, DSG1, VIM
41serine448.1TP53, FCER2, CLU, DSP, DSG1, DSG3
42tyrosine448.0DSG3, DSP, CLU, FCER2, FSCN1, IL2RA
43paraffin448.0SLC2A1, TP53, FCER2, CLU, VIM, FSCN1
44calcium44 50 24 1110.5DSP, CLU, CLDN1, FCER2, DSG1, DSG3

GO Terms for genes affiliated with Dendritic Cell Sarcoma

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Cellular components related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:00153310.0EVPL, DSP
2desmosomeGO:0300578.7PPL, DSP, DSG1, DSG3, EVPL
3extracellular vesicular exosomeGO:0700626.8SLC2A1, PPL, FCER2, CLU, DSP, DSG3
4plasma membraneGO:0058866.3PPL, FCER2, DSP, DSG1, DSG3, VIM

Biological processes related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:04510910.0DSP, VIM
2peptide cross-linkingGO:0181499.9DSP, EVPL
3release of cytochrome c from mitochondriaGO:0018369.9CLU, TP53
4complement activation, classical pathwayGO:0069589.9CR2, CR1, CLU
5cellular response to glucose starvationGO:0421499.9SLC2A1, TP53
6Notch signaling pathwayGO:0072199.8IL2RA, FCER2, TP53
7actin filament bundle assemblyGO:0510179.5FSCN1, FSCN2
8cellular component disassembly involved in execution phase of apoptosisGO:0069219.4VIM, DSG3, DSG1, DSP
9apoptotic processGO:0069158.8TP53, DSP, DSG1, DSG3, VIM, IL2RA

Molecular functions related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051989.8EVPL, DSP, CLDN1
2scaffold protein bindingGO:0971109.8VIM, DSP
3structural constituent of cytoskeletonGO:0052009.7PPL, DSP
4identical protein bindingGO:0428029.1TP53, CLDN1, VIM, SLC2A1
5actin filament bindingGO:0510159.0FSCN1, FSCN2, FSCN3
6protein binding, bridgingGO:0306748.6EVPL, FSCN1, FSCN2, FSCN3, DSP

Products for genes affiliated with Dendritic Cell Sarcoma

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Sources for Dendritic Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet