MCID: DND002
MIFTS: 54

Dendritic Cell Sarcoma malady

Cancer diseases, Blood diseases categories

Summaries for Dendritic Cell Sarcoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A histiocytic and dendritic cell cancer that is mainly located in lymph nodes.

MalaCards: Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, not otherwise specified, is related to sarcoma and follicular dendritic cell sarcoma. An important gene associated with Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Immune response Lectin induced complement pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cycloheximide and cr2+ have been mentioned in the context of this disorder. Affiliated tissues include lymph nodes, lymph node and tonsil, and related mouse phenotypes are hematopoietic system and cellular.

Aliases & Classifications for Dendritic Cell Sarcoma

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8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Aliases & Descriptions:

dendritic cell sarcoma 8 10
dendritic cell sarcoma, not otherwise specified 8
dendritic cell sarcoma not otherwise specified 48
dendritic cell sarcoma, interdigitating 60


External Ids:

Disease Ontology8 DOID:7849
NCIt39 C27260
SNOMED-CT via Orphanet57 397355008
ICD10 via Orphanet26 C96.4
UMLS via Orphanet61 C1301364
ICD1025 C96.4

Related Diseases for Dendritic Cell Sarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.8TP53, VIM, PPL, CR2, DSP, DSG1
2follicular dendritic cell sarcoma31.7PPL
3pemphigus30.9PPL, DSP, DSG3, DSG1, EVPL
4leukemia30.6CR2, CR1, IL2RA, FCER2, EVPL, TP53
5myasthenia gravis30.5CR1
6hepatitis30.3CR1
7histiocytosis30.3FSCN1, CD68
8chronic lymphocytic leukemia30.3CR2, CR1, IL2RA, FCER2
9amyloidosis30.1CLU, SNCG
10thymoma30.1PPL, DSP, EVPL
11leiomyosarcoma30.1VIM, CR2, TP53
12interdigitating dendritic cell sarcoma10.9
13tonsillitis10.6
14liver sarcoma10.5
15small cell sarcoma10.4
16mediastinitis10.4
17langerhans cell sarcoma10.3
18pharyngitis10.3
19cervicitis10.3
20lung sarcoma10.3
21retroperitoneal sarcoma10.3
22thyroid sarcoma10.3
23thyroiditis10.3
24vascular disease10.3
25breast sarcoma10.2
26hairy cell leukemia10.2
27mediastinum sarcoma10.2
28small intestinal sarcoma10.2
29pancreas sarcoma10.1
30epstein-barr virus hepatitis10.1
31cellulitis10.1
32liver inflammatory pseudotumor10.1
33bone lymphoma10.1
34bladder sarcoma10.1
35spindle cell sarcoma10.1
36retroperitoneal leiomyosarcoma10.1
37kidney leiomyosarcoma10.1
38nasopharyngitis10.1
39acute leukemia10.1
40bladder calculus10.1
41colon sarcoma10.1
42dendritic cell thymoma10.1
43epithelioid sarcoma10.1
44intestinal disease10.1
45intestinal perforation10.1
46kidney sarcoma10.1
47langerhans-cell histiocytosis10.1
48skin sarcoma10.1
49uterine disease10.1
50follicular dendritic cell tumor10.1

Graphical network of the top 20 diseases related to Dendritic Cell Sarcoma:



Diseases related to dendritic cell sarcoma

Clinical Features for Dendritic Cell Sarcoma

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Drugs & Therapeutics for Dendritic Cell Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Dendritic Cell Sarcoma

Drug clinical trials:

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Search NIH Clinical Center for Dendritic Cell Sarcoma

Search CenterWatch for Dendritic Cell Sarcoma

Genetic Tests for Dendritic Cell Sarcoma

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Anatomical Context for Dendritic Cell Sarcoma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Dendritic Cell Sarcoma:

32
Lymph node, Tonsil, Liver, T cells, Bone, Spleen, Thyroid, Lung, Breast, Skin, Bone marrow, Small intestine, Salivary gland, Cervix, Pancreas, Colon, Endothelial, B cells, Myeloid, Kidney, Appendix

FMA organs/tissues related to Dendritic Cell Sarcoma:

14
Lymph nodes

Animal Models for Dendritic Cell Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dendritic Cell Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.5TNFRSF8, CR2, DSG3, CD68, CXCL13, IL2RA
2MP:00053846.9TP53, VIM, SLC2A1, FCER2, FSCN1, IL2RA
3MP:00053876.7CXCL13, FCER2, FSCN1, IL2RA, CLU, CD68

Publications for Dendritic Cell Sarcoma

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50PubMed
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Articles related to Dendritic Cell Sarcoma:

(show top 50)    (show all 211)
idTitleAuthorsYear
1
A rare case of follicular dendritic cell sarcoma involving multiple bones. (23640234)
2013
2
Interdigitating dendritic cell sarcoma complicated with paraneoplastic pemphigus after surgery of resection. (23652075)
2013
3
Interdigitating dendritic cell sarcoma presenting simultaneously with acute myelomonocytic leukemia: report of a rare case and literature review. (23605368)
2013
4
Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. (23755890)
2013
5
Killing two birds with one stone: BRAF V600E inhibitor therapy for hairy cell leukemia and Langerhans/dendritic cell sarcoma. (23322213)
2013
6
Cytogenetic abnormalities in follicular dendritic cell sarcoma: report of two cases and literature review. (23422480)
2013
7
Follicular dendritic cell sarcoma of the tonsil. (23415609)
2013
8
Pediatric follicular dendritic cell sarcoma of the head and neck: a case report and review of the literature. (23684177)
2013
9
A case of interdigitating dendritic cell sarcoma/histiocytic sarcoma - a diagnostic pitfall. (24427360)
2013
10
A rare case of interdigitating dendritic cell sarcoma in the nasal cavity. (23710400)
2013
11
Interdigitating dendritic cell sarcoma occured alone in axilla. (22563543)
2012
12
Pathology quiz case 1. Follicular dendritic cell sarcoma (FDS). (22801898)
2012
13
Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor. (22938549)
2012
14
Follicular dendritic cell sarcoma: a diagnostic challenge ! (22842383)
2012
15
F-18 FDG PET/CT imaging of follicular dendritic cell sarcoma of the mediastinum. (22228355)
2012
16
Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients. (21398051)
2012
17
Narrow-band imaging of interdigitating dendritic cell sarcoma originating in the duodenum. (21425001)
2011
18
Follicular dendritic cell sarcoma of the lung: a report of two cases highlighting its pathological features and diagnostic pitfalls. (21240069)
2011
19
Interdigitating dendritic cell sarcoma: case report with review of the literature. (22104162)
2011
20
Follicular dendritic cell sarcoma of the neck with pulmonary metastases. (21914416)
2011
21
Clinicopathological features and prognosis assessment of extranodal follicular dendritic cell sarcoma. (20503450)
2010
22
Follicular dendritic cell sarcoma presenting in the submandibular region in an 11 year-old. (21225781)
2010
23
Interdigitating dendritic cell sarcoma involving bone marrow in a liver transplant recipient. (20620556)
2010
24
Follicular dendritic cell sarcoma of the neck with an aggressive and fatal course. (20479564)
2010
25
Interdigitating dendritic cell sarcoma of the tonsil. (20887493)
2010
26
A follicular dendritic cell sarcoma of the mediastinum with immature T cells and association with myasthenia gravis. (20305533)
2010
27
Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro. (19432677)
2009
28
Follicular dendritic cell sarcoma/tumor: 2 cases of a rare tumor of difficult clinical and pathological diagnosis. (19608084)
2009
29
SIR 2008 annual meeting film panel case: Castleman disease complicated by follicular dendritic cell sarcoma. (18656005)
2008
30
Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma. (18786443)
2008
31
Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. (18272816)
2008
32
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma without Castleman's disease; treatment with rituximab. (18477166)
2008
33
Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. (18792075)
2008
34
Follicular dendritic cell sarcoma: a rare tumor presenting as an abdominal mass. (17652548)
2007
35
Diagnosis and recurrence of follicular dendritic cell sarcoma. (17967656)
2007
36
Follicular dendritic cell sarcoma mimicking giant cell carcinoma of the pancreas. (16872443)
2006
37
Follicular dendritic cell sarcoma of the tonsil: case report. (16896752)
2006
38
Interdigitating dendritic cell sarcoma/tumour of the tonsil. (16281930)
2005
39
Tumour lines from a spontaneous rat endometrial stromal sarcoma, showing dendritic cell-like and myofibroblastic cell-like phenotypes. (15144798)
2004
40
Mediastinal follicular dendritic cell sarcoma. (12604428)
2003
41
Immunophenotypical changes of neoplastic cells and tumor-associated macrophages in a rat dendritic cell sarcoma-derived transplantable tumor line (KB-D8). (12596065)
2003
42
Immunotherapy with autologous dendritic cells and tumor-specific synthetic peptides for synovial sarcoma. (11990310)
2002
43
Establishment and characterization of transplantable tumor line (KB) and cell lines (KB-P and KB-D8) from a rat thymus-derived dendritic cell sarcoma. (12070602)
2002
44
Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature. (11796841)
2002
45
Interdigitating dendritic cell sarcoma of the spleen: report of a case with a review of the literature. (11914634)
2002
46
Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman's disease of the nasopharynx: tracing its evolution by sequential biopsies. (11422494)
2001
47
Cutaneous indeterminate cell histiocytosis: a new spindle cell variant resembling dendritic cell sarcoma. (11737523)
2001
48
Follicular dendritic cell sarcoma: ultrastructural and immunohistochemical studies. (11065250)
2000
49
Follicular dendritic cell sarcoma of lymph node--report of fine needle aspiration (FNA) cytological appearances. (10588352)
1999
50
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma arising from Castleman's tumor. (10025851)
1999

Genetic Variations for Dendritic Cell Sarcoma

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Expression for genes affiliated with Dendritic Cell Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dendritic Cell Sarcoma

Search GEO for disease gene expression data for Dendritic Cell Sarcoma.

Pathways for genes affiliated with Dendritic Cell Sarcoma

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12EMD Millipore, 53Reactome, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Dendritic Cell Sarcoma

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6CR1
2cr2+4410.4CR2, CR1
3mycophenolate sodium4410.3CR1, IL2RA
4asulam4410.3PPL, DSP
5okt34410.2FCER2, IL2RA, CR2
6cytochalasin b4410.1VIM, FCER2, SLC2A1
7ricin a4410.0TNFRSF8, IL2RA
8paclitaxel44 49 1112.0TP53, CLU, SNCG
9tunicamycin44 5911.0CLU, FCER2, SLC2A1
10toxin a449.9DSG1, DSG3
11ivig449.9IL2RA, DSG1, DSG3
12calcitriol44 59 11 2412.9SLC2A1, FCER2, IL2RA, CLU
13formaldehyde44 2410.9VIM, CR1, IL2RA, FCER2
14heparin44 28 11 2412.8SLC2A1, IL2RA, CLU, CR1
155-aza-2deoxycytidine449.7TP53, CLU, SNCG, VIM
16cytarabine44 49 1111.7TP53, CR1, VIM
17etoposide44 49 59 1112.7TP53, IL2RA, CLU, VIM
1812-o-tetradecanoylphorbol 13-acetate449.6VIM, DSP, FSCN1, FCER2
19vitamin d449.5VIM, CR1, CLU, IL2RA
20thymidine44 2410.4TNFRSF8, CLU, IL2RA, FCER2, TP53
21serine449.2DSP, DSG3, DSG1, CLU, FSCN1, FCER2
22acetylcholine44 49 28 11 2413.2IL2RA, DSG1, DSG3, VIM
23estrogen449.1VIM, CR2, SNCG, CLU, IL2RA, SLC2A1
24retinoic acid44 2410.0VIM, CR1, DSP, DSG1, CLU, FSCN1
25tyrosine448.0TNFRSF8, CR2, CR1, SNCG, DSP, DSG3
26paraffin447.8TP53, VIM, TNFRSF8, CR2, CR1, CD68
27calcium44 49 11 2410.7DSP, SNCG, CR1, CR2, TNFRSF8, DSG3

GO Terms for genes affiliated with Dendritic Cell Sarcoma

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16Gene Ontology
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Cellular components related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300578.9EVPL, DSG1, DSG3, DSP, PPL
2plasma membraneGO:0058866.8SNCG, CR1, CR2, PPL, TNFRSF8, DSP

Biological processes related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activation, classical pathwayGO:0069589.9CLU, CR1, CR2
2intermediate filament organizationGO:0451099.9DSP, VIM
3cellular response to glucose starvationGO:0421499.7SLC2A1, TP53
4cellular component disassembly involved in execution phase of apoptosisGO:0069219.6DSG1, DSG3, DSP, VIM
5positive regulation of apoptotic processGO:0430659.3TNFRSF8, CLU, IL2RA, TP53
6apoptotic processGO:0069159.2IL2RA, DSG1, DSG3, DSP, VIM

Molecular functions related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.7DSP, PPL, VIM
2protein binding, bridgingGO:0306749.5EVPL, FSCN1, DSP

Products for genes affiliated with Dendritic Cell Sarcoma

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Sources for Dendritic Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet