MCID: DND002
MIFTS: 55

Dendritic Cell Sarcoma malady

Cancer diseases, Blood diseases, Rare diseases categories

Summaries for Dendritic Cell Sarcoma

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Disease Ontology:10 A histiocytic and dendritic cell cancer that is mainly located in lymph nodes.

MalaCards based summary: Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, not otherwise specified, is related to follicular dendritic cell sarcoma and sarcoma. An important gene associated with Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Complement Pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cr2+ and mycophenolate sodium have been mentioned in the context of this disorder. Affiliated tissues include lymph nodes, lymph node and tonsil, and related mouse phenotypes are mortality/aging and hematopoietic system.

Aliases & Classifications for Dendritic Cell Sarcoma

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Sources:
10Disease Ontology, 12DISEASES, 49Orphanet, 62UMLS, 57SNOMED-CT, 40NCIt, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Dendritic Cell Sarcoma, Aliases & Descriptions:

Name: Dendritic Cell Sarcoma 10 12
Dendritic Cell Sarcoma, Not Otherwise Specified 10
 
Dendritic Cell Sarcoma Not Otherwise Specified 49
Dendritic Cell Sarcoma, Interdigitating 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


External Ids:

Disease Ontology10 DOID:7849
NCIt40 C27260
Orphanet49 86903
ICD10 via Orphanet28 C96.4
UMLS via Orphanet63 C1301364
ICD1027 C96.4

Related Diseases for Dendritic Cell Sarcoma

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Diseases related to Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1follicular dendritic cell sarcoma32.0PPL
2sarcoma31.9CR2, FSCN1, VIM, DSG1, DSP, CLU
3pemphigus31.1EVPL, DSG1, DSG3, PPL, DSP
4leukemia30.7TP53, FCER2, IL2RA, CR1, EVPL, CR2
5follicular lymphoma30.5CR1, CR2, FCER2
6chronic lymphocytic leukemia30.5CR1, FCER2, CR2, IL2RA
7histiocytosis30.4FSCN1, FSCN3, FSCN2, CD68
8thymoma30.3PPL, EVPL, DSP
9langerhans-cell histiocytosis30.3CD68, FSCN1
10leiomyosarcoma30.2CR2, TP53, VIM
11melanoma30.1CD68, TP53, CR1, FSCN1, DSG1, VIM
12interdigitating dendritic cell sarcoma11.0
13tonsillitis10.7
14paraneoplastic pemphigus10.7
15castleman's disease10.6
16mediastinitis10.5
17thyroiditis10.5
18myasthenia gravis10.4
19cervicitis10.4
20hepatitis10.3
21pharyngitis10.3
22kaposi sarcoma10.2
23retroperitoneal leiomyosarcoma10.2
24nasopharyngitis10.2
25amyloidosis10.2
26cellulitis10.2
27intestinal perforation10.2
28peritonitis10.2
29acute myelomonocytic leukemia10.2
30dendritic cell tumor10.2
31indeterminate cell histiocytosis10.2
32histiocytic sarcoma10.2
33secondary amyloidosis10.2
34palmoplantar keratoderma, nonepidermolytic10.1EVPL
35pemphigus vegetans10.1DSG1
36hailey-hailey disease10.1DSP
37hypersensitivity syndrome, carbamazepine-induced10.1DSG1
38subcorneal pustular dermatosis10.1DSG1
39multicentric castleman’s disease10.1DSG3, FSCN1
40choroid plexus papilloma10.1TP53
41pemphigus erythematosus10.0DSG3, DSP
42epidermolysis bullosa acquisita10.0DSG1
43bullous skin disease10.0DSG3, DSG1, EVPL
44keratoderma10.0DSG1, DSP
45bullous pemphigoid10.0EVPL, PPL, DSP
46keratosis10.0DSP
47palmoplantar keratosis10.0DSG1, DSP
48fibrous histiocytoma10.0VIM, FSCN1
49anaplastic large cell lymphoma10.0CLU, FSCN1, IL2RA
50pemphigus foliaceus10.0DSG1, PPL, DSG3, EVPL

Graphical network of the top 20 diseases related to Dendritic Cell Sarcoma:



Diseases related to dendritic cell sarcoma

Symptoms for Dendritic Cell Sarcoma

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Drugs & Therapeutics for Dendritic Cell Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Dendritic Cell Sarcoma

Search NIH Clinical Center for Dendritic Cell Sarcoma

Genetic Tests for Dendritic Cell Sarcoma

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Anatomical Context for Dendritic Cell Sarcoma

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MalaCards organs/tissues related to Dendritic Cell Sarcoma:

33
Lymph node, Tonsil, Liver, Bone, Spleen, Thyroid, Bone marrow, Lung, T cells, Brain, Small intestine, Colon, Breast, Skin, Kidney, Pancreas, Salivary gland, Testis, Cervix, B cells, Appendix

FMA organs/tissues related to Dendritic Cell Sarcoma:

16
Lymph nodes

Animal Models for Dendritic Cell Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Dendritic Cell Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0FCER2, CLDN1, DSP, DSG3, VIM, IL2RA
2MP:00053977.3TP53, FCER2, DSG3, VIM, CXCL13, IL2RA
3MP:00053847.2TP53, FCER2, DSP, DSG3, VIM, FSCN1
4MP:00053877.0CD68, TP53, FCER2, CLU, DSG3, VIM

Publications for Dendritic Cell Sarcoma

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Articles related to Dendritic Cell Sarcoma:

(show top 50)    (show all 222)
idTitleAuthorsYear
1
Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature. (25893828)
2015
2
Follicular dendritic cell sarcoma of the tonsil. (25512260)
2015
3
Follicular dendritic cell sarcoma of the right tonsil: A case report and literature review. (25621026)
2015
4
Intraperitoneal follicular dendritic cell sarcoma: role of chemotherapy and bone marrow allotransplantation in locally advanced disease? (25698886)
2015
5
Paraneoplastic pemphigus associated with primary pulmonar follicular dendritic cell sarcoma showing good response to treatment. (25388966)
2014
6
Interdigitating dendritic cell sarcoma presenting in the kidney combined with retroperitoneal leiomyosarcoma: A case report and literature review. (24396471)
2014
7
The genetics of interdigitating dendritic cell sarcoma share some changes with Langerhans cell histiocytosis in select cases. (24321462)
2014
8
Interdigitating dendritic cell sarcoma presenting in the skin: diagnosis and the role of surgical resection, chemotherapy and radiotherapy in management. (25568750)
2014
9
Extranodal follicular dendritic cell sarcoma of the soft palate: a case report. (25674273)
2014
10
Regulation of the exopolysaccharide from an anamorph of Cordyceps sinensis on dendritic cell sarcoma (DCS) cell line. (22610670)
2013
11
Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of six cases with increased IgG4-positive plasma cells. (23714251)
2013
12
A rare case of follicular dendritic cell sarcoma involving multiple bones. (23640234)
2013
13
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
14
Interdigitating dendritic cell sarcoma complicated with paraneoplastic pemphigus after surgery of resection. (23652075)
2013
15
Interdigitating dendritic cell sarcoma presenting simultaneously with acute myelomonocytic leukemia: report of a rare case and literature review. (23605368)
2013
16
Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. (23755890)
2013
17
Interdigitating dendritic cell sarcoma occured alone in axilla. (22563543)
2012
18
Pathology quiz case 1. Follicular dendritic cell sarcoma (FDS). (22801898)
2012
19
Extranodal follicular dendritic cell sarcoma with rapid growth in parapharynx: a case report. (23110021)
2012
20
Computed tomography and 18F-fluoro-2-deoxyglucose positron emission tomography findings of primary pulmonary follicular dendritic cell sarcoma: case report and a literature review. (21795995)
2012
21
Small intestine perforation due to metastatic uterine cervix interdigitating dendritic cell sarcoma: a rare manifestation of a rare disease. (22355501)
2011
22
I^-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. (21959308)
2011
23
Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review. (21813397)
2011
24
Narrow-band imaging of interdigitating dendritic cell sarcoma originating in the duodenum. (21425001)
2011
25
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
26
Follicular dendritic cell sarcoma of the abdomen: the imaging findings. (20191073)
2010
27
Follicular dendritic cell sarcoma of small intestine with aberrant T-cell marker expression. (19883432)
2009
28
SIR 2008 annual meeting film panel case: Castleman disease complicated by follicular dendritic cell sarcoma. (18656005)
2008
29
Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma. (18786443)
2008
30
Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. (18272816)
2008
31
Interdigitating dendritic cell sarcoma of the eyelid with a rapidly fatal course. (18474795)
2008
32
Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. (17721283)
2007
33
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
34
Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. (18194598)
2007
35
Interdigitating dendritic cell sarcoma of the parotid gland. (16372988)
2006
36
Interwoven dendritic processes of follicular dendritic cell sarcoma demonstrated on ultrafast papanicolaou-stained smears: a case report. (17017440)
2006
37
Clonal cytogenetic abnormalities and BCL2 rearrangement in interdigitating dendritic cell sarcoma. (17169812)
2006
38
Follicular dendritic cell sarcoma of lymph node--a rare entity. (16696516)
2006
39
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma and Castleman disease. (16029358)
2005
40
Interdigitating dendritic cell sarcoma/tumour of the tonsil. (16281930)
2005
41
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus. (16120143)
2005
42
Follicular dendritic cell sarcoma: case report and review of current management principles. (16343408)
2005
43
Paraneoplastic pemphigus revealing dendritic cell sarcoma originating from Castleman's disease of the neck]. (15746607)
2005
44
Mediastinal mixed dendritic cell sarcoma with hybrid features. (12354813)
2002
45
Follicular dendritic cell sarcoma of the neck; a case report and literature review. (12393051)
2002
46
Fine needle aspiration cytology of follicular dendritic cell sarcoma. Report of a case with cytologic detection in an extranodal site. (11015984)
2000
47
Extranodal follicular dendritic cell sarcoma of the palate. (10052377)
1999
48
Myxoid variant of follicular dendritic cell sarcoma arising in the breast. (10196389)
1999
49
Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. (9010103)
1997
50
Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma: a case report. (9256295)
1997

Variations for Dendritic Cell Sarcoma

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Expression for genes affiliated with Dendritic Cell Sarcoma

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Search GEO for disease gene expression data for Dendritic Cell Sarcoma.

Pathways for genes affiliated with Dendritic Cell Sarcoma

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Pathways related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.8CR2, CR1, CLU
29.7VIM, DSP, CLDN1
39.5FCER2, IL2RA, CR1, CR2
4
Show member pathways
9.5CR2, IL2RA, FCER2, TP53
59.4TP53, FCER2, VIM, CR2
6
Show member pathways
9.2DSP, DSG1, DSG3, VIM
79.2EVPL, VIM, DSP, PPL
8
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.9TP53, DSP, DSG1, DSG3, VIM

Compounds for genes affiliated with Dendritic Cell Sarcoma

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Compounds related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1cr2+4510.4CR2, CR1
2mycophenolate sodium4510.3CR1, IL2RA
3okt34510.2FCER2, IL2RA, CR2
4tunicamycin45 6111.2SLC2A1, CLU, FCER2
5toxin a4510.1DSG1, DSG3
6asulam4510.1DSP, PPL
7cytochalasin b4510.1SLC2A1, VIM, FCER2
8aristolochic acid45 311.1VIM, TP53
9calcitriol45 61 26 1312.9FCER2, CLU, IL2RA, SLC2A1
10ivig459.9DSG1, DSG3, IL2RA
11mannose459.9FCER2, CR1, SLC2A1
12vincristine45 51 1311.9IL2RA, VIM, TP53
13cytarabine45 51 1311.9TP53, VIM, CR1
14formaldehyde45 2610.8CR1, IL2RA, VIM, FCER2
15folate459.8IL2RA, VIM, CLU
16temozolomide45 1310.8VIM, TP53
17vitamin d459.8CLU, VIM, IL2RA, CR1
18etoposide45 51 61 1312.7IL2RA, VIM, CLU, TP53
19prednisolone45 30 1311.7CR1, IL2RA, DSG3
20butyrate459.7TP53, CLU, VIM, SLC2A1
2112-o-tetradecanoylphorbol 13-acetate459.7FCER2, DSP, VIM, FSCN1
22lactate459.7FCER2, CLU, VIM, SLC2A1
23genistein45 30 61 3 26 1314.7FCER2, VIM, IL2RA, SLC2A1
24fmlp459.7FCER2, VIM, CR1
25actinomycin d459.7TP53, CLU, VIM, SLC2A1
26doxorubicin45 51 1311.7TP53, CLU, VIM, IL2RA
27thymidine45 2610.7TP53, FCER2, CLU, IL2RA
28dmso459.7CR1, VIM, DSP
295-aza-2deoxycytidine459.6TP53, CLU, VIM, SNCG
30cisplatin45 51 61 1312.6SLC2A1, IL2RA, CLU, TP53
31dexamethasone45 51 30 1312.6SLC2A1, IL2RA, VIM, CLU, FCER2
32acetylcholine45 51 30 26 1313.6IL2RA, VIM, DSG3, DSG1
33heparin45 30 26 1312.5CLU, VIM, IL2RA, CR1, SLC2A1
34vegf459.4TP53, CLU, VIM, IL2RA, SLC2A1
35paclitaxel45 51 1311.4TP53, CLU, VIM, IL2RA, SNCG
36atp45 3010.3FCER2, CLU, VIM, CR1, SLC2A1
37cycloheximide459.1TP53, FCER2, CLU, VIM, CR1, CR2
38cysteine458.9FCER2, CLU, VIM, IL2RA, SLC2A1
39estrogen458.9TP53, CLU, VIM, IL2RA, SNCG, CR2
40retinoic acid45 269.7TP53, FCER2, CLU, DSP, DSG1, VIM
41serine458.1TP53, FCER2, CLU, DSP, DSG1, DSG3
42tyrosine458.0DSG3, DSP, CLU, FCER2, FSCN1, IL2RA
43paraffin458.0SLC2A1, TP53, FCER2, CLU, VIM, FSCN1
44calcium45 51 26 1310.5DSP, CLU, CLDN1, FCER2, DSG1, DSG3

GO Terms for genes affiliated with Dendritic Cell Sarcoma

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Cellular components related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:000153310.0EVPL, DSP
2desmosomeGO:00300578.7PPL, DSP, DSG1, DSG3, EVPL
3extracellular vesicular exosomeGO:00700626.8SLC2A1, PPL, FCER2, CLU, DSP, DSG3
4plasma membraneGO:00058866.3PPL, FCER2, DSP, DSG1, DSG3, VIM

Biological processes related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:004510910.0DSP, VIM
2peptide cross-linkingGO:00181499.9DSP, EVPL
3release of cytochrome c from mitochondriaGO:00018369.9CLU, TP53
4complement activation, classical pathwayGO:00069589.9CR2, CR1, CLU
5cellular response to glucose starvationGO:00421499.9SLC2A1, TP53
6Notch signaling pathwayGO:00072199.8IL2RA, FCER2, TP53
7actin filament bundle assemblyGO:00510179.5FSCN1, FSCN2
8cellular component disassembly involved in execution phase of apoptosisGO:00069219.4VIM, DSG3, DSG1, DSP
9apoptotic processGO:00069158.8TP53, DSP, DSG1, DSG3, VIM, IL2RA

Molecular functions related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:00051989.8EVPL, DSP, CLDN1
2scaffold protein bindingGO:00971109.8VIM, DSP
3structural constituent of cytoskeletonGO:00052009.7PPL, DSP
4identical protein bindingGO:00428029.1TP53, CLDN1, VIM, SLC2A1
5actin filament bindingGO:00510159.0FSCN1, FSCN2, FSCN3
6protein binding, bridgingGO:00306748.6EVPL, FSCN1, FSCN2, FSCN3, DSP

Products for genes affiliated with Dendritic Cell Sarcoma

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Sources for Dendritic Cell Sarcoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet