MCID: DND002
MIFTS: 54

Dendritic Cell Sarcoma malady

Cancer diseases, Blood diseases categories

Summaries for Dendritic Cell Sarcoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A histiocytic and dendritic cell cancer that is mainly located in lymph nodes.

MalaCards: Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, not otherwise specified, is related to sarcoma and follicular dendritic cell sarcoma. An important gene associated with Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Immune response Lectin induced complement pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cycloheximide and cr2+ have been mentioned in the context of this disorder. Affiliated tissues include lymph nodes, lymph node and tonsil, and related mouse phenotypes are hematopoietic system and cellular.

Aliases & Classifications for Dendritic Cell Sarcoma

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8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Aliases & Descriptions:

dendritic cell sarcoma 8 10
dendritic cell sarcoma, not otherwise specified 8
dendritic cell sarcoma not otherwise specified 48
dendritic cell sarcoma, interdigitating 60


External Ids:

Disease Ontology8 DOID:7849
NCIt39 C27260
SNOMED-CT via Orphanet57 397355008
ICD10 via Orphanet26 C96.4
UMLS via Orphanet61 C1301364
ICD1025 C96.4

Related Diseases for Dendritic Cell Sarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.8TP53, VIM, PPL, CR2, DSP, DSG1
2follicular dendritic cell sarcoma31.7PPL
3pemphigus30.9PPL, DSP, DSG3, DSG1, EVPL
4leukemia30.6CR2, CR1, IL2RA, FCER2, EVPL, TP53
5myasthenia gravis30.5CR1
6hepatitis30.3CR1
7histiocytosis30.3FSCN1, CD68
8chronic lymphocytic leukemia30.3CR2, CR1, IL2RA, FCER2
9amyloidosis30.1CLU, SNCG
10thymoma30.1PPL, DSP, EVPL
11leiomyosarcoma30.1VIM, CR2, TP53
12interdigitating dendritic cell sarcoma10.9
13tonsillitis10.6
14liver sarcoma10.5
15small cell sarcoma10.4
16mediastinitis10.4
17langerhans cell sarcoma10.3
18pharyngitis10.3
19cervicitis10.3
20lung sarcoma10.3
21retroperitoneal sarcoma10.3
22thyroid sarcoma10.3
23thyroiditis10.3
24vascular disease10.3
25breast sarcoma10.2
26hairy cell leukemia10.2
27mediastinum sarcoma10.2
28small intestinal sarcoma10.2
29pancreas sarcoma10.1
30epstein-barr virus hepatitis10.1
31cellulitis10.1
32liver inflammatory pseudotumor10.1
33bone lymphoma10.1
34bladder sarcoma10.1
35spindle cell sarcoma10.1
36retroperitoneal leiomyosarcoma10.1
37kidney leiomyosarcoma10.1
38nasopharyngitis10.1
39acute leukemia10.1
40bladder calculus10.1
41colon sarcoma10.1
42dendritic cell thymoma10.1
43epithelioid sarcoma10.1
44intestinal disease10.1
45intestinal perforation10.1
46kidney sarcoma10.1
47langerhans-cell histiocytosis10.1
48skin sarcoma10.1
49uterine disease10.1
50follicular dendritic cell tumor10.1

Graphical network of the top 20 diseases related to Dendritic Cell Sarcoma:



Diseases related to dendritic cell sarcoma

Clinical Features for Dendritic Cell Sarcoma

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Drugs & Therapeutics for Dendritic Cell Sarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Dendritic Cell Sarcoma

Search NIH Clinical Center for Dendritic Cell Sarcoma

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Genetic Tests for Dendritic Cell Sarcoma

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Anatomical Context for Dendritic Cell Sarcoma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Dendritic Cell Sarcoma:

32
Lymph node, Tonsil, Liver, T cells, Bone, Spleen, Thyroid, Lung, Breast, Skin, Bone marrow, Small intestine, Salivary gland, Cervix, Pancreas, Colon, Endothelial, B cells, Myeloid, Kidney, Appendix

FMA organs/tissues related to Dendritic Cell Sarcoma:

14
Lymph nodes

Animal Models for Dendritic Cell Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dendritic Cell Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.5TNFRSF8, CR2, DSG3, CD68, CXCL13, IL2RA
2MP:00053846.9DSP, SNCG, CR2, TIMD4, VIM, DSG3
3MP:00053876.7TP53, VIM, TIMD4, TNFRSF8, CR2, DSG3

Publications for Dendritic Cell Sarcoma

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50PubMed
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Articles related to Dendritic Cell Sarcoma:

(show top 50)    (show all 211)
idTitleAuthorsYear
1
Interdigitating dendritic cell sarcoma presenting in the kidney combined with retroperitoneal leiomyosarcoma: A case report and literature review. (24396471)
2014
2
Paraneoplastic pemphigus as the first manifestation of follicular dendritic cell sarcoma. (24119156)
2014
3
A pan-inhibitor of DASH family enzymes induces immune-mediated regression of murine sarcoma and is a potent adjuvant to dendritic cell vaccination and adoptive T-cell therapy. (23994886)
2013
4
Transformation of Castleman's disease into follicular dendritic cell sarcoma, presenting as an asymptomatic intra-abdominal mass. (23981949)
2013
5
Intraabdominal follicular dendritic cell sarcoma: a report of three cases and review of the literature. (23748832)
2013
6
Follicular dendritic cell sarcoma of the omentum: multidetector computed tomography findings. (23483068)
2013
7
Follicular dendritic cell sarcoma of the pharyngeal region. (23761812)
2013
8
Follicular dendritic cell sarcoma of the tonsil. (23365157)
2013
9
Computed tomography and 18F-fluoro-2-deoxyglucose positron emission tomography findings of primary pulmonary follicular dendritic cell sarcoma: case report and a literature review. (21795995)
2012
10
Interdigitating dendritic cell sarcoma presenting in the nasal region. (22554504)
2012
11
Nasopharyngeal dendritic cell sarcoma, not otherwise specified, in a 34-year-old man. (21674462)
2011
12
Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven cases. (21666687)
2011
13
Interdigitating dendritic cell sarcoma following adult liver transplantation: case report and literature review. (21052884)
2011
14
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
15
Follicular dendritic cell sarcoma: a report of six cases and a review of the Chinese literature. (20937101)
2010
16
Castleman's disease associated with follicular dendritic cell sarcoma and myasthenia gravis. (21225186)
2010
17
Follicular dendritic cell sarcoma of tonsil. (20141695)
2010
18
Fine needle aspiration of follicular dendritic cell sarcoma in an HIV-positive man: a case report. (20968160)
2010
19
Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: a case report and review of literature. (19343479)
2009
20
Dendritic cell sarcoma: an analytic overview of the literature and presentation of original five cases. (17658269)
2008
21
Follicular dendritic cell sarcoma of the head and neck: case report and literature review. (18596475)
2008
22
Cytopathology of a primary follicular dendritic cell sarcoma of the liver of the inflammatory pseudotumor-like type. (18064686)
2008
23
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
24
Interwoven dendritic processes of follicular dendritic cell sarcoma demonstrated on ultrafast papanicolaou-stained smears: a case report. (17017440)
2006
25
Interdigitating dendritic cell sarcoma of cervical lymph nodes. (17116824)
2006
26
Intra-abdominal follicular dendritic cell sarcoma. (17134976)
2006
27
Follicular dendritic cell sarcoma in pregnancy: case report and review of the literature. (17094047)
2006
28
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma and Castleman disease. (16029358)
2005
29
Follicular dendritic cell sarcoma: case report and review of current management principles. (16343408)
2005
30
Symptoms in cancer patients and an unusual tumor: Case 3. Follicular dendritic cell sarcoma. (16361643)
2005
31
Expression profiles of mouse dendritic cell sarcoma are similar to those of hematopoietic stem cells or progenitors by clustering and principal component analyses. (15845378)
2005
32
A survey of clusterin and fascin expression in sarcomas and spindle cell neoplasms: strong clusterin immunostaining is highly specific for follicular dendritic cell tumor. (15467709)
2005
33
Primary mediastinal lymph node malignancy with features suggestive of dendritic cell sarcoma. (16095239)
2005
34
A 70-year-old man with multiple intra-abdominal masses and liver and spleen metastases. Intra-abdominal follicular dendritic cell sarcoma with liver and spleen metastases. (15859660)
2005
35
Interdigitating dendritic reticulum cell sarcoma: cytologic, histologic and immunocytochemical features. (15945093)
2005
36
Dendritic cell sarcoma of the oral cavity. (14747067)
2004
37
Interdigitating dendritic cell sarcoma: a report of four paediatric cases and review of the literature. (14987233)
2004
38
Follicular dendritic cell sarcoma of the pharyngeal region: histologic, cytologic, immunohistochemical, and ultrastructural study of three cases. (15614735)
2004
39
Histiocytic sarcoma with interdigitating dendritic cell differentiation. (15591905)
2004
40
Follicular dendritic cell sarcoma of the tonsil: report of a rare case. (12955835)
2003
41
Follicular dendritic cell sarcoma of the breast. (12189511)
2002
42
Reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features. (11598178)
2001
43
Follicular dendritic cell sarcoma of the colon mimicking stromal tumour. (11135043)
2001
44
Extranodal follicular dendritic cell sarcoma of the palate. (10052377)
1999
45
Myxoid variant of follicular dendritic cell sarcoma arising in the breast. (10196389)
1999
46
Dendritic cell sarcoma of the thyroid. (10208672)
1999
47
Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review. (9766802)
1998
48
Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma: a case report. (9256295)
1997
49
Follicular dendritic cell sarcoma complicated by hyaline-vascular type Castleman's disease in a schizophrenic patient. (9361105)
1997
50
The human progenitor cell antigen (CD34) is localized on endothelial cells, dermal dendritic cells, and perifollicular cells in formalin-fixed normal skin, and on proliferating endothelial cells and stromal spindle-shaped cells in Kaposi's sarcoma. (2006877)
1991

Genetic Variations for Dendritic Cell Sarcoma

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Expression for genes affiliated with Dendritic Cell Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dendritic Cell Sarcoma

Search GEO for disease gene expression data for Dendritic Cell Sarcoma.

Pathways for genes affiliated with Dendritic Cell Sarcoma

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12EMD Millipore, 53Reactome, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Dendritic Cell Sarcoma

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 28IUPHAR
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Compounds related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6CR1
2cr2+4410.4CR2, CR1
3mycophenolate sodium4410.3CR1, IL2RA
4asulam4410.3PPL, DSP
5okt34410.2FCER2, IL2RA, CR2
6cytochalasin b4410.1VIM, FCER2, SLC2A1
7ricin a4410.0TNFRSF8, IL2RA
8paclitaxel44 49 1112.0TP53, CLU, SNCG
9tunicamycin44 5911.0CLU, FCER2, SLC2A1
10toxin a449.9DSG1, DSG3
11ivig449.9IL2RA, DSG1, DSG3
12calcitriol44 59 11 2412.9SLC2A1, FCER2, IL2RA, CLU
13formaldehyde44 2410.9VIM, CR1, IL2RA, FCER2
14heparin44 28 11 2412.8SLC2A1, IL2RA, CLU, CR1
155-aza-2deoxycytidine449.7TP53, CLU, SNCG, VIM
16cytarabine44 49 1111.7TP53, CR1, VIM
17etoposide44 49 59 1112.7TP53, IL2RA, CLU, VIM
1812-o-tetradecanoylphorbol 13-acetate449.6VIM, DSP, FSCN1, FCER2
19vitamin d449.5VIM, CR1, CLU, IL2RA
20thymidine44 2410.4TNFRSF8, CLU, IL2RA, FCER2, TP53
21serine449.2DSP, DSG3, DSG1, CLU, FSCN1, FCER2
22acetylcholine44 49 28 11 2413.2IL2RA, DSG1, DSG3, VIM
23estrogen449.1VIM, CR2, SNCG, CLU, IL2RA, SLC2A1
24retinoic acid44 2410.0VIM, CR1, DSP, DSG1, CLU, FSCN1
25tyrosine448.0TNFRSF8, CR2, CR1, SNCG, DSP, DSG3
26paraffin447.8TP53, VIM, TNFRSF8, CR2, CR1, CD68
27calcium44 49 11 2410.7DSP, SNCG, CR1, CR2, TNFRSF8, DSG3

GO Terms for genes affiliated with Dendritic Cell Sarcoma

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16Gene Ontology
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Cellular components related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300578.9EVPL, DSG1, DSG3, DSP, PPL
2plasma membraneGO:0058866.8SNCG, CR1, CR2, PPL, TNFRSF8, DSP

Biological processes related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activation, classical pathwayGO:0069589.9CLU, CR1, CR2
2intermediate filament organizationGO:0451099.9DSP, VIM
3cellular response to glucose starvationGO:0421499.7SLC2A1, TP53
4cellular component disassembly involved in execution phase of apoptosisGO:0069219.6DSG1, DSG3, DSP, VIM
5positive regulation of apoptotic processGO:0430659.3TNFRSF8, CLU, IL2RA, TP53
6apoptotic processGO:0069159.2IL2RA, DSG1, DSG3, DSP, VIM

Molecular functions related to Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.7DSP, PPL, VIM
2protein binding, bridgingGO:0306749.5EVPL, FSCN1, DSP

Products for genes affiliated with Dendritic Cell Sarcoma

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  • Antibodies
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Sources for Dendritic Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet