MCID: DND002
MIFTS: 48

Dendritic Cell Sarcoma malady

Cancer diseases, Blood diseases, Rare diseases categories

Aliases & Classifications for Dendritic Cell Sarcoma

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Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 48Orphanet, 56SNOMED-CT, 39NCIt, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Dendritic Cell Sarcoma:

Name: Dendritic Cell Sarcoma 8 10
Dendritic Cell Sarcoma, Not Otherwise Specified 8 61
 
Dendritic Cell Sarcoma Not Otherwise Specified 48
Dendritic Cell Sarcoma, Interdigitating 61


Classifications:



External Ids:

Disease Ontology8 DOID:7849
NCIt39 C27260
Orphanet48 86903
ICD10 via Orphanet26 C96.4
UMLS via Orphanet62 C1301364
ICD1025 C96.4

Summaries for Dendritic Cell Sarcoma

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Disease Ontology:8 A histiocytic and dendritic cell cancer that is mainly located in lymph nodes.

MalaCards based summary: Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, not otherwise specified, is related to follicular dendritic cell sarcoma and pemphigus. An important gene associated with Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Complement Pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cr2+ and mycophenolate sodium have been mentioned in the context of this disorder. Affiliated tissues include lymph nodes, lymph node and tonsil, and related mouse phenotypes are mortality/aging and hematopoietic system.

Related Diseases for Dendritic Cell Sarcoma

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Diseases related to Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1follicular dendritic cell sarcoma32.7PPL
2pemphigus31.3PPL, DSP, DSG1, DSG3, EVPL
3sarcoma31.1PPL, EVPL, CR2, FSCN1, VIM, DSG1
4follicular lymphoma30.8CR2, CR1, FCER2
5thymoma30.7PPL, DSP, EVPL
6langerhans-cell histiocytosis30.6FSCN1, CD68
7chronic lymphocytic leukemia30.6FCER2, IL2RA, CR1, CR2
8leukemia30.4TP53, FCER2, IL2RA, CR1, CR2, EVPL
9leiomyosarcoma30.4TP53, VIM, CR2
10histiocytosis30.0FSCN3, FSCN2, FSCN1, CD68
11melanoma29.6TP53, DSG1, VIM, FSCN1, CR1, CD68
12interdigitating dendritic cell sarcoma11.0
13tonsillitis10.7
14paraneoplastic pemphigus10.7
15castleman's disease10.6
16palmoplantar keratoderma, nonepidermolytic10.6EVPL
17mediastinitis10.5
18pemphigus vegetans10.5DSG1
19hailey-hailey disease10.5DSP
20hypersensitivity syndrome, carbamazepine-induced10.5DSG1
21subcorneal pustular dermatosis10.5DSG1
22thyroiditis10.5
23multicentric castleman’s disease10.4FSCN1, DSG3
24choroid plexus papilloma10.4TP53
25epidermolysis bullosa acquisita10.4DSG1
26pemphigus erythematosus10.4DSG3, DSP
27myasthenia gravis10.4
28cervicitis10.4
29bullous skin disease10.3DSG1, DSG3, EVPL
30keratoderma10.3DSG1, DSP
31bullous pemphigoid10.3EVPL, DSP, PPL
32keratosis10.3DSP
33palmoplantar keratosis10.3DSP, DSG1
34hepatitis10.3
35pharyngitis10.3
36dendritic cell tumor10.3
37fibrous histiocytoma10.3VIM, FSCN1
38anaplastic large cell lymphoma10.3IL2RA, FSCN1, CLU
39pemphigus foliaceus10.2PPL, DSG1, DSG3, EVPL
40allergic asthma10.2CR2, IL2RA, FCER2
41burkitt lymphoma10.2CR2, CXCL13, FCER2
42reticulosarcoma10.2CLU, FSCN1, CD68
43skin disease10.2DSG3, DSG1, DSP, FCER2
44lymphoma, non-hodgkin10.2FCER2, FSCN1, IL2RA, CR2
45membranous glomerulonephritis, antenatal10.2CLU, CR1
46esophageal cancer10.2TP53, DSG1, FSCN1
47sarcoidosis 110.2FCER2, IL2RA, CR1
48kaposi sarcoma10.2
49retroperitoneal leiomyosarcoma10.2
50nasopharyngitis10.2

Graphical network of the top 20 diseases related to Dendritic Cell Sarcoma:



Diseases related to dendritic cell sarcoma

Symptoms for Dendritic Cell Sarcoma

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Drugs & Therapeutics for Dendritic Cell Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Dendritic Cell Sarcoma

Search NIH Clinical Center for Dendritic Cell Sarcoma

Genetic Tests for Dendritic Cell Sarcoma

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Anatomical Context for Dendritic Cell Sarcoma

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MalaCards organs/tissues related to Dendritic Cell Sarcoma:

31
Lymph node, Tonsil, Liver, Bone, Spleen, Thyroid, Bone marrow, Lung, T cells, Brain, Small intestine, Colon, Breast, Skin, Kidney, Pancreas, Salivary gland, Testis, Cervix, B cells, Appendix

FMA organs/tissues related to Dendritic Cell Sarcoma:

14
Lymph nodes

Animal Models for Dendritic Cell Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Dendritic Cell Sarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0FCER2, CLDN1, DSP, DSG3, VIM, IL2RA
2MP:00053977.3TP53, FCER2, DSG3, VIM, CXCL13, IL2RA
3MP:00053847.2TP53, FCER2, DSP, DSG3, VIM, FSCN1
4MP:00053877.0CD68, TP53, FCER2, CLU, DSG3, VIM

Publications for Dendritic Cell Sarcoma

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Articles related to Dendritic Cell Sarcoma:

(show top 50)    (show all 222)
idTitleAuthorsYear
1
Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature. (25893828)
2015
2
Follicular dendritic cell sarcoma of the tonsil. (25512260)
2015
3
Follicular dendritic cell sarcoma of the right tonsil: A case report and literature review. (25621026)
2015
4
Intraperitoneal follicular dendritic cell sarcoma: role of chemotherapy and bone marrow allotransplantation in locally advanced disease? (25698886)
2015
5
Paraneoplastic pemphigus associated with primary pulmonar follicular dendritic cell sarcoma showing good response to treatment. (25388966)
2014
6
Interdigitating dendritic cell sarcoma presenting in the kidney combined with retroperitoneal leiomyosarcoma: A case report and literature review. (24396471)
2014
7
The genetics of interdigitating dendritic cell sarcoma share some changes with Langerhans cell histiocytosis in select cases. (24321462)
2014
8
Interdigitating dendritic cell sarcoma presenting in the skin: diagnosis and the role of surgical resection, chemotherapy and radiotherapy in management. (25568750)
2014
9
Extranodal follicular dendritic cell sarcoma of the soft palate: a case report. (25674273)
2014
10
Regulation of the exopolysaccharide from an anamorph of Cordyceps sinensis on dendritic cell sarcoma (DCS) cell line. (22610670)
2013
11
Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of six cases with increased IgG4-positive plasma cells. (23714251)
2013
12
A rare case of follicular dendritic cell sarcoma involving multiple bones. (23640234)
2013
13
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
14
Interdigitating dendritic cell sarcoma complicated with paraneoplastic pemphigus after surgery of resection. (23652075)
2013
15
Interdigitating dendritic cell sarcoma presenting simultaneously with acute myelomonocytic leukemia: report of a rare case and literature review. (23605368)
2013
16
Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. (23755890)
2013
17
Interdigitating dendritic cell sarcoma occured alone in axilla. (22563543)
2012
18
Pathology quiz case 1. Follicular dendritic cell sarcoma (FDS). (22801898)
2012
19
Extranodal follicular dendritic cell sarcoma with rapid growth in parapharynx: a case report. (23110021)
2012
20
Computed tomography and 18F-fluoro-2-deoxyglucose positron emission tomography findings of primary pulmonary follicular dendritic cell sarcoma: case report and a literature review. (21795995)
2012
21
Small intestine perforation due to metastatic uterine cervix interdigitating dendritic cell sarcoma: a rare manifestation of a rare disease. (22355501)
2011
22
I^-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. (21959308)
2011
23
Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review. (21813397)
2011
24
Narrow-band imaging of interdigitating dendritic cell sarcoma originating in the duodenum. (21425001)
2011
25
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
26
Follicular dendritic cell sarcoma of the abdomen: the imaging findings. (20191073)
2010
27
Follicular dendritic cell sarcoma of small intestine with aberrant T-cell marker expression. (19883432)
2009
28
SIR 2008 annual meeting film panel case: Castleman disease complicated by follicular dendritic cell sarcoma. (18656005)
2008
29
Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma. (18786443)
2008
30
Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. (18272816)
2008
31
Interdigitating dendritic cell sarcoma of the eyelid with a rapidly fatal course. (18474795)
2008
32
Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. (17721283)
2007
33
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
34
Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. (18194598)
2007
35
Interdigitating dendritic cell sarcoma of the parotid gland. (16372988)
2006
36
Interwoven dendritic processes of follicular dendritic cell sarcoma demonstrated on ultrafast papanicolaou-stained smears: a case report. (17017440)
2006
37
Clonal cytogenetic abnormalities and BCL2 rearrangement in interdigitating dendritic cell sarcoma. (17169812)
2006
38
Follicular dendritic cell sarcoma of lymph node--a rare entity. (16696516)
2006
39
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma and Castleman disease. (16029358)
2005
40
Interdigitating dendritic cell sarcoma/tumour of the tonsil. (16281930)
2005
41
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus. (16120143)
2005
42
Follicular dendritic cell sarcoma: case report and review of current management principles. (16343408)
2005
43
Paraneoplastic pemphigus revealing dendritic cell sarcoma originating from Castleman's disease of the neck]. (15746607)
2005
44
Mediastinal mixed dendritic cell sarcoma with hybrid features. (12354813)
2002
45
Follicular dendritic cell sarcoma of the neck; a case report and literature review. (12393051)
2002
46
Fine needle aspiration cytology of follicular dendritic cell sarcoma. Report of a case with cytologic detection in an extranodal site. (11015984)
2000
47
Extranodal follicular dendritic cell sarcoma of the palate. (10052377)
1999
48
Myxoid variant of follicular dendritic cell sarcoma arising in the breast. (10196389)
1999
49
Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. (9010103)
1997
50
Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma: a case report. (9256295)
1997

Variations for Dendritic Cell Sarcoma

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Expression for genes affiliated with Dendritic Cell Sarcoma

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Search GEO for disease gene expression data for Dendritic Cell Sarcoma.

Pathways for genes affiliated with Dendritic Cell Sarcoma

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Pathways related to Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway59
Immune response Lectin Induced complement pathway59
Immune response Classic complement pathway59
9.8CR2, CR1, CLU
29.7VIM, DSP, CLDN1
39.5FCER2, IL2RA, CR1, CR2
4
Show member pathways
9.5CR2, IL2RA, FCER2, TP53
59.4TP53, FCER2, VIM, CR2
6
Show member pathways
9.2DSP, DSG1, DSG3, VIM
79.2EVPL, VIM, DSP, PPL
8
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I59
8.9TP53, DSP, DSG1, DSG3, VIM

Compounds for genes affiliated with Dendritic Cell Sarcoma

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Compounds related to Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 44)
idCompoundScoreTop Affiliating Genes
1cr2+4410.4CR1, CR2
2mycophenolate sodium4410.3IL2RA, CR1
3okt34410.2CR2, IL2RA, FCER2
4tunicamycin44 6011.2FCER2, SLC2A1, CLU
5toxin a4410.1DSG1, DSG3
6asulam4410.1DSP, PPL
7cytochalasin b4410.1SLC2A1, VIM, FCER2
8aristolochic acid44 111.1VIM, TP53
9calcitriol44 60 24 1112.9FCER2, CLU, IL2RA, SLC2A1
10ivig449.9DSG3, DSG1, IL2RA
11mannose449.9SLC2A1, CR1, FCER2
12vincristine44 50 1111.9TP53, IL2RA, VIM
13cytarabine44 50 1111.9TP53, VIM, CR1
14formaldehyde44 2410.8FCER2, VIM, IL2RA, CR1
15folate449.8VIM, IL2RA, CLU
16temozolomide44 1110.8VIM, TP53
17vitamin d449.8CLU, IL2RA, CR1, VIM
18etoposide44 50 60 1112.7IL2RA, CLU, TP53, VIM
19prednisolone44 28 1111.7CR1, IL2RA, DSG3
20butyrate449.7TP53, CLU, VIM, SLC2A1
2112-o-tetradecanoylphorbol 13-acetate449.7DSP, FCER2, FSCN1, VIM
22lactate449.7SLC2A1, CLU, FCER2, VIM
23genistein44 28 60 1 24 1114.7VIM, FCER2, SLC2A1, IL2RA
24fmlp449.7CR1, VIM, FCER2
25actinomycin d449.7SLC2A1, VIM, CLU, TP53
26doxorubicin44 50 1111.7TP53, CLU, VIM, IL2RA
27thymidine44 2410.7IL2RA, FCER2, CLU, TP53
28dmso449.7DSP, CR1, VIM
295-aza-2deoxycytidine449.6TP53, SNCG, VIM, CLU
30cisplatin44 50 60 1112.6CLU, IL2RA, SLC2A1, TP53
31dexamethasone44 50 28 1112.6SLC2A1, FCER2, VIM, IL2RA, CLU
32acetylcholine44 50 28 24 1113.6DSG1, VIM, DSG3, IL2RA
33heparin44 28 24 1112.5SLC2A1, CR1, IL2RA, VIM, CLU
34vegf449.4IL2RA, SLC2A1, TP53, CLU, VIM
35paclitaxel44 50 1111.4CLU, VIM, TP53, SNCG, IL2RA
36atp44 2810.3VIM, CR1, FCER2, CLU, SLC2A1
37cycloheximide449.1CLU, FCER2, VIM, CR1, CR2, SLC2A1
38cysteine448.9SLC2A1, IL2RA, FCER2, CLU, VIM
39estrogen448.9TP53, CLU, SNCG, CR2, SLC2A1, VIM
40retinoic acid44 249.7CLU, FCER2, DSG1, TP53, VIM, FSCN1
41serine448.1DSG1, DSG3, VIM, FSCN1, DSP, SLC2A1
42tyrosine448.0CLU, CR1, SNCG, CR2, IL2RA, FCER2
43paraffin448.0FCER2, SLC2A1, TP53, CR2, CLU, VIM
44calcium44 50 24 1110.5CR2, CR1, SNCG, CXCL13, FSCN1, DSG3

GO Terms for genes affiliated with Dendritic Cell Sarcoma

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Cellular components related to Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cornified envelopeGO:000153310.0EVPL, DSP
2desmosomeGO:00300578.7PPL, DSP, DSG1, DSG3, EVPL
3extracellular vesicular exosomeGO:00700626.8SLC2A1, PPL, FCER2, CLU, DSP, DSG3
4plasma membraneGO:00058866.3PPL, FCER2, DSP, DSG1, DSG3, VIM

Biological processes related to Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:004510910.0DSP, VIM
2peptide cross-linkingGO:00181499.9DSP, EVPL
3release of cytochrome c from mitochondriaGO:00018369.9CLU, TP53
4complement activation, classical pathwayGO:00069589.9CR2, CR1, CLU
5cellular response to glucose starvationGO:00421499.9SLC2A1, TP53
6Notch signaling pathwayGO:00072199.8IL2RA, FCER2, TP53
7actin filament bundle assemblyGO:00510179.5FSCN1, FSCN2
8cellular component disassembly involved in execution phase of apoptosisGO:00069219.4VIM, DSG3, DSG1, DSP
9apoptotic processGO:00069158.8TP53, DSP, DSG1, DSG3, VIM, IL2RA

Molecular functions related to Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:00051989.8EVPL, DSP, CLDN1
2scaffold protein bindingGO:00971109.8VIM, DSP
3structural constituent of cytoskeletonGO:00052009.7PPL, DSP
4identical protein bindingGO:00428029.1TP53, CLDN1, VIM, SLC2A1
5actin filament bindingGO:00510159.0FSCN1, FSCN2, FSCN3
6protein binding, bridgingGO:00306748.6EVPL, FSCN1, FSCN2, FSCN3, DSP

Sources for Dendritic Cell Sarcoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet