MCID: DNG003
MIFTS: 64

Dengue Disease malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Dengue Disease

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Sources:
30LifeMap Discovery®, 9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 32MedlinePlus, 3CDC, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Dengue Disease, Aliases & Descriptions:

Name: Dengue Disease 30 9 11
Dengue Fever 9 41 47 3 60
Dengue Shock Syndrome 41 60
Dengue 43 32
Df 47 3
Philippine Hemorrhagic Fever 41
Singapore Hemorrhagic Fever 41
 
Dengue Hemorrhagic Fever 41
Dengue Virus Infection 47
Thai Hemorrhagic Fever 41
Hemorrhagic Dengue 41
Breakbone Fever 9
Classic Dengue 9
Severe Dengue 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

47
dengue fever:
Prevalence: >1/1000 (Worldwide); Age of onset: All ages; Age of death: any age


External Ids:

Disease Ontology9 DOID:12205
NCIt38 C34528
MeSH33 D003715
ICD9CM27 061
Orphanet47 99828
MESH via Orphanet34 D003715
ICD10 via Orphanet26 A90, A91
UMLS via Orphanet61 C0011311
ICD1025 A90

Summaries for Dengue Disease

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MedlinePlus:32 Dengue is an infection caused by a virus. you can get it if an infected mosquito bites you. dengue does not spread from person to person. it is common in warm, wet areas of the world. outbreaks occur in the rainy season. dengue is rare in the united states. symptoms include a high fever, headaches, joint and muscle pain, vomiting, and a rash. in some cases, dengue turns into dengue hemorrhagic fever, which causes bleeding from your nose, gums, or under your skin. it can also become dengue shock syndrome, which causes massive bleeding and shock. these forms of dengue are life-threatening. there is no specific treatment. most people with dengue recover within 2 weeks. until then, drinking lots of fluids, resting and taking non-aspirin fever-reducing medicines might help. people with the more severe forms of dengue usually need to go to the hospital and get fluids. to lower your risk when traveling in dengue-prone countries wear insect repellent with deet wear clothes that cover your arms, legs and feet close unscreened doors and windows nih: national institute of allergy and infectious diseases

MalaCards based summary: Dengue Disease, also known as dengue fever, is related to malaria and yellow fever, and has symptoms including migraine, abnormality of temperature regulation and skin rash. An important gene associated with Dengue Disease is CD209 (CD209 molecule), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and LDL Oxidation in Atherogenesis. The compounds polymyxin b and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and bone, and related mouse phenotypes are integument and immune system.

Disease Ontology:9 A viral infectious disease that results in infection, has material basis in dengue virus [ncbitaxon:12637] with four serotypes (dengue virus 1, 2, 3 and 4), which are transmitted by aedes mosquito bite. the infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.

Related Diseases for Dengue Disease

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Diseases related to Dengue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 213)
idRelated DiseaseScoreTop Affiliating Genes
1malaria31.1ICAM1
2yellow fever30.8RAF1, CSPG5, PRNT, KRAS
3tick-borne encephalitis30.7RAF1
4lupus nephritis30.7ICAM1, MBL2, VCAM1
5pneumonia30.5IL11, MBL2, ICAM1
6thyroiditis30.5MBL2
7thrombocytosis30.4IL11, THPO
8neutropenia30.4THPO, MBL2, IL11
9aplastic anemia30.4THPO, IL11
10vasculitis30.3ICAM1, VCAM1, MBL2
11systemic lupus erythematosus30.2MBL2, ICAM1, VCAM1
12allergic rhinitis30.2ICAM1, MBL2, VCAM1
13tuberculosis30.1SP1, IL11, MBL2, CD209
14thrombocytopenia30.1RAF1, THPO, IL11
15pancreatitis30.0ICAM1, IL11, KRAS
16glomerulonephritis30.0VCAM1, ICAM1, MBL2
17rhinitis29.9ICAM1, VCAM1
18hepatitis c29.8KRAS, RAF1, THPO, CD209
19asthma29.8MBL2, RAF1, IL11, ICAM1, VCAM1
20hepatitis b29.7SP1, MBL2, RAF1, KRAS
21hiv-129.7RAF1, SP1, CD209, THPO
22myeloma29.7VCAM1, ICAM1, IL11
23myeloid leukemia29.7RAF1, SP1, THPO, IL11
24leukemia29.2THPO, SP1, ICAM1, IL11, RAF1, KRAS
25breast cancer29.1RAF1, SP1, THPO, KRAS, IL11
26melanoma29.0KRAS, ICAM1, VCAM1, RAF1, SP1
27west nile virus10.5
28dengue fever, protection against10.5
29acalculous cholecystitis10.5
30cholecystitis10.5
31hemophagocytic lymphohistiocytosis10.5
32pituitary apoplexy10.5
33atrial fibrillation10.4
34compartment syndrome10.4
35acquired thrombocytopenia10.4IL11, THPO
36thrombocytopenic purpura, autoimmune10.3THPO, IL11
37megakaryocytic leukemia10.3IL11, THPO
38aspergillosis10.3
39leptospirosis10.3
40chikungunya10.3
41encephalitis10.3
42typhus10.3
43nephritis10.3
44refractory anemia10.3IL11, THPO
45essential thrombocythemia10.3THPO, IL11
46cardiofaciocutaneous syndrome10.3KRAS
47arteriosclerosis obliterans10.3ICAM1, VCAM1
48henoch-schoenlein purpura10.3VCAM1, ICAM1
49inclusion body myositis10.3ICAM1, VCAM1
50rheumatoid vasculitis10.3ICAM1, VCAM1

Graphical network of the top 20 diseases related to Dengue Disease:



Diseases related to dengue disease

Symptoms for Dengue Disease

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Symptoms:

 47 9 (show all 30)
  • facial pain/cephalalgia/migraine
  • fever/chilling
  • cutaneous rash
  • pruritus/itching
  • acute abdominal pain/colic
  • articular/joint pain/arthralgia
  • purpura/petichiae
  • ecchymoses
  • ascitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute diarrhea
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • hepatomegaly/liver enlargement (excluding storage disease)
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • hypotension
  • obnubilation/coma/lethargia/desorientation
  • leukopenia/hypoleukocytosis
  • thrombocytopenia/thrombopenia
  • epistaxis/nose bleeding
  • gingivorrhagia/gingival bleeding
  • intracranial/cerebral/meningeal hemorrhage
  • hypoproteinemia
  • early death/lethality
  • fever
  • severe headache
  • severe pain behind the eyes
  • joint pain
  • muscle
  • rash
  • mild bleeding

HPO human phenotypes related to Dengue Disease:

(show all 21)
id Description Frequency HPO Source Accession
1 migraine hallmark (90%) HP:0002076
2 abnormality of temperature regulation hallmark (90%) HP:0004370
3 skin rash typical (50%) HP:0000988
4 pruritus typical (50%) HP:0000989
5 abdominal pain typical (50%) HP:0002027
6 arthralgia typical (50%) HP:0002829
7 gingival bleeding occasional (7.5%) HP:0000225
8 epistaxis occasional (7.5%) HP:0000421
9 bruising susceptibility occasional (7.5%) HP:0000978
10 ascites occasional (7.5%) HP:0001541
11 sudden cardiac death occasional (7.5%) HP:0001645
12 thrombocytopenia occasional (7.5%) HP:0001873
13 leukopenia occasional (7.5%) HP:0001882
14 diarrhea occasional (7.5%) HP:0002014
15 nausea and vomiting occasional (7.5%) HP:0002017
16 intracranial hemorrhage occasional (7.5%) HP:0002170
17 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
18 hepatomegaly occasional (7.5%) HP:0002240
19 hypotension occasional (7.5%) HP:0002615
20 hypoproteinemia occasional (7.5%) HP:0003075
21 reduced consciousness/confusion occasional (7.5%) HP:0004372

Drugs & Therapeutics for Dengue Disease

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Drug clinical trials:

Search ClinicalTrials for Dengue Disease

Search NIH Clinical Center for Dengue Disease

Genetic Tests for Dengue Disease

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Anatomical Context for Dengue Disease

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MalaCards organs/tissues related to Dengue Disease:

31
Skin, Eye, Bone, Brain, Neutrophil, Liver, T cells, Bone marrow, Smooth muscle, Adipocyte, Thyroid, Placenta, Testis, Nk cells, Endothelial, Testes, Monocytes

Animal Models for Dengue Disease or affiliated genes

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MGI Mouse Phenotypes related to Dengue Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1KRAS, RAF1, ICAM1, SP1, SPAG9
2MP:00053877.9CD209, THPO, CLEC5A, VCAM1, ICAM1, RAF1
3MP:00053977.7SP1, THPO, VCAM1, ICAM1, RAF1, KRAS
4MP:00053767.5SP1, VCAM1, ICAM1, RAF1, KRAS, MBL2

Publications for Dengue Disease

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Articles related to Dengue Disease:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Antibodies against immature virions are not a discriminating factor for dengue disease severity. (25760350)
2015
2
Evolution of dengue disease and entomological monitoring in Santa Cruz, Bolivia 2002 - 2008. (25706631)
2015
3
Epidemiological trends of dengue disease in Colombia (2000-2011): a systematic review. (25790245)
2015
4
CD8+ T cells prevent antigen-induced antibody-dependent enhancement of dengue disease in mice. (25217165)
2014
5
Evaluation of the WHO classification of dengue disease severity during an epidemic in 2011 in the state of CearA!, Brazil. (24626308)
2014
6
Epidemiological trends of dengue disease in Mexico (2000-2011): a systematic literature search and analysis. (25375162)
2014
7
Dengue disease surveillance: an updated systematic literature review. (24889501)
2014
8
Association between proinflammatory cytokines and lipid peroxidation in patients with severe dengue disease around defervescence. (24216294)
2014
9
Epidemiology of Dengue Disease in the Philippines (2000-2011): A Systematic Literature Review. (25375119)
2014
10
First experimental in vivo model of enhanced dengue disease severity through maternally acquired heterotypic dengue antibodies. (24699622)
2014
11
Dengue disease outbreak detection. (25160360)
2014
12
Predictive symptoms and signs of severe dengue disease for patients with dengue fever: a meta-analysis. (25097856)
2014
13
Dengue disease surveillance: improving data for dengue control. (25375232)
2014
14
Epidemiology of dengue disease in malaysia (2000-2012): a systematic literature review. (25375211)
2014
15
Reviewing the literature for epidemiological trends of dengue disease: introduction to a series of seven national systematic literature reviews. (25375830)
2014
16
Dogma in classifying dengue disease. (23926138)
2013
17
Epidemiological trends of dengue disease in Brazil (2000-2010): a systematic literature search and analysis. (24386496)
2013
18
The battle between infection and host immune responses of dengue virus and its implication in dengue disease pathogenesis. (23476150)
2013
19
An optimal control problem arising from a dengue disease transmission model. (23274179)
2013
20
Atypical presentations of dengue disease in the elderly visiting the ED. (23399333)
2013
21
Comment on: "Atypical presentations of dengue disease in the elderly visiting the ED" (24342867)
2013
22
Can non-human primates serve as models for investigating dengue disease pathogenesis? (24130557)
2013
23
Assessing weather effects on dengue disease in malaysia. (24287855)
2013
24
Simple Prognostic Criteria can Definitively Identify Patients who Develop Severe Versus Non-Severe Dengue Disease, or Have Other Febrile Illnesses. (22383925)
2012
25
Unfolded protein response (UPR) gene expression during antibody-dependent enhanced infection of cultured monocytes correlates with dengue disease severity. (20858223)
2011
26
Biosensors and rapid diagnostic tests on the frontier between analytical and clinical chemistry for biomolecular diagnosis of dengue disease: a review. (21241843)
2011
27
Virus role during intraepidemic increase in dengue disease severity. (21254883)
2011
28
Evaluation of the traditional and revised WHO classifications of Dengue disease severity. (22087348)
2011
29
Molecular mimicry between virus and host and its implications for dengue disease pathogenesis. (21502191)
2011
30
Characterization of early host responses in adults with dengue disease. (21810247)
2011
31
Clinical and virological factors influencing the performance of a NS1 antigen-capture assay and potential use as a marker of dengue disease severity. (21811645)
2011
32
Changing trends of dengue disease: a brief report from a tertiary care hospital in New Delhi. (21503411)
2011
33
Influence of environmental conditions on asynchronous outbreaks of dengue disease and increasing vector population in Kaohsiung, Taiwan. (21424970)
2011
34
Markers of dengue disease severity. (19802579)
2010
35
Characteristic of dengue disease in Taiwan: 2002-2007. (20348527)
2010
36
A BALB/c mouse model shows that liver involvement in dengue disease is immune-mediated. (20673760)
2010
37
Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease. (20153282)
2010
38
Stochastic eco-epidemiological model of dengue disease transmission by Aedes aegypti mosquito. (19861133)
2010
39
Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification. (20168989)
2010
40
Understanding the contribution of cellular immunity to dengue disease pathogenesis. (18837790)
2008
41
Describing the geographic spread of dengue disease by traveling waves. (18590749)
2008
42
Blood group AB is associated with increased risk for severe dengue disease in secondary infections. (17330792)
2007
43
NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease. (16412060)
2006
44
Relationship of thrombopoietin and interleukin-11 levels to thrombocytopenia associated with dengue disease. (16759877)
2006
45
Genetic variations and relationship among dengue virus type 3 strains isolated from patients with mild or severe form of dengue disease in Indonesia and Thailand. (16438144)
2005
46
Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999. (12641411)
2003
47
Immunology and immunopathogenesis of dengue disease. (14689699)
2003
48
Dengue disease spectrum among infants in the 2001 dengue epidemic in Chennai, Tamil Nadu, India. (12904418)
2003
49
A model for dengue disease with variable human population. (10220925)
1999
50
Analysis of a dengue disease transmission model. (9656647)
1998

Variations for Dengue Disease

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Expression for genes affiliated with Dengue Disease

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LifeMap Discovery
Genes differentially expressed in tissues of Dengue Disease patients vs. healthy controls: 30 (show all 163)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1PIPprolactin-induced proteinSkin-5.800.000
2DCDdermcidinSkin-5.360.000
3SCGB1D2secretoglobin, family 1D, member 2Skin-5.140.000
4SCGB2A2secretoglobin, family 2A, member 2Skin-4.870.000
5IFI27interferon, alpha-inducible protein 27Blood+4.850.000
6C5orf46chromosome 5 open reading frame 46Skin-4.530.000
7RRM2ribonucleotide reductase M2Blood+4.480.000
8CEP55centrosomal protein 55kDaBlood+4.330.000
9MED27mediator complex subunit 27Skin-4.310.000
10BIRC5baculoviral IAP repeat containing 5Blood+4.300.000
11SERPINA12serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12Skin-4.250.000
12CD38CD38 moleculeBlood+4.230.000
13KRT27keratin 27Skin-4.130.000
14DAPL1death associated protein-like 1Skin-4.100.000
15DLGAP5discs, large (Drosophila) homolog-associated protein 5Blood+4.100.000
16BUB1BUB1 mitotic checkpoint serine/threonine kinaseBlood+4.080.000
17THRSPthyroid hormone responsiveSkin-4.060.000
18IGHMimmunoglobulin heavy constant muBlood+4.040.000
19CHP2calcineurin-like EF-hand protein 2Skin-4.030.000
20MCM10minichromosome maintenance complex component 10Blood+3.990.000
21SHCBP1SHC SH2-domain binding protein 1Blood+3.970.000
22PBKPDZ binding kinaseBlood+3.970.000
23TYMSthymidylate synthetaseBlood+3.960.000
24FLG2filaggrin family member 2Skin-3.940.000
25KRT25keratin 25Skin-3.910.000
26CDCA2cell division cycle associated 2Blood+3.910.000
27HMMRhyaluronan-mediated motility receptor (RHAMM)Blood+3.830.000
28MKI67marker of proliferation Ki-67Blood+3.830.000
29ZWINTZW10 interacting kinetochore proteinBlood+3.830.000
30KRT15keratin 15Skin-3.830.000
31DTLdenticleless E3 ubiquitin protein ligase homolog (Drosophila)Blood+3.800.000
32CDK1cyclin-dependent kinase 1Blood+3.780.000
33NCAPGnon-SMC condensin I complex, subunit GBlood+3.760.000
34CDT1chromatin licensing and DNA replication factor 1Blood+3.760.000
35SPC25SPC25, NDC80 kinetochore complex componentBlood+3.750.000
36CD247CD247 moleculeSkin+3.750.000
37CD48CD48 moleculeSkin+3.740.000
38SOD2superoxide dismutase 2, mitochondrialSkin+3.730.000
39CDC20cell division cycle 20Blood+3.730.000
40LILRB4leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4Skin+3.720.000
41TOP2Atopoisomerase (DNA) II alpha 170kDaBlood+3.710.000
42EIF1AYeukaryotic translation initiation factor 1A, Y-linkedBlood+3.690.015
43ATP6V1B1ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1Skin-3.680.000
44SLC7A7solute carrier family 7 (amino acid transporter light chain, y+L system), member 7Skin+3.650.000
45SCGB2A1secretoglobin, family 2A, member 1Skin-3.650.000
46IGLL3Pimmunoglobulin lambda-like polypeptide 3, pseudogeneSkin+3.640.000
47IFNGinterferon, gammaSkin+3.640.000
48MT1Hmetallothionein 1HSkin+3.630.000
49SIGLEC10sialic acid binding Ig-like lectin 10Skin+3.630.000
50ISG15ISG15 ubiquitin-like modifierSkin+3.620.000
51LAPTM5lysosomal protein transmembrane 5Skin+3.620.000
52CCNB2cyclin B2Blood+3.620.000
53S100A7S100 calcium binding protein A7Skin+3.620.000
54CDKN3cyclin-dependent kinase inhibitor 3Blood+3.620.000
55KIAA0101KIAA0101Blood+3.610.000
56IL7Rinterleukin 7 receptorSkin+3.610.000
57TLR8toll-like receptor 8Skin+3.610.000
58KIF2Ckinesin family member 2CBlood+3.600.000
59TK1thymidine kinase 1, solubleBlood+3.590.000
60LCE5Alate cornified envelope 5ASkin-3.570.000
61RPS4Y1ribosomal protein S4, Y-linked 1Blood+3.570.017
62PLAC8placenta-specific 8Skin+3.570.000
63TTKTTK protein kinaseBlood+3.560.000
64CDC6cell division cycle 6Blood+3.560.000
65CAV1caveolin 1, caveolae protein, 22kDaBlood+3.560.000
66FNDC1fibronectin type III domain containing 1Skin+3.550.000
67KRT77keratin 77Skin-3.540.000
68TGM2transglutaminase 2Skin+3.540.000
69CENPAcentromere protein ABlood+3.540.000
70LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2Skin+3.530.000
71VSIG8V-set and immunoglobulin domain containing 8Skin-3.530.000
72SPRR2Asmall proline-rich protein 2ASkin+3.530.000
73CYAT1immunoglobulin lambda light chain-likeBlood+3.520.000
74ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Blood+3.520.000
75CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)Skin+3.500.000
76CD163CD163 moleculeSkin+3.500.000
77UHRF1ubiquitin-like with PHD and ring finger domains 1Blood+3.500.000
78GINS2GINS complex subunit 2 (Psf2 homolog)Blood+3.490.000
79CD53CD53 moleculeSkin+3.490.000
80OAS22'-5'-oligoadenylate synthetase 2, 69/71kDaSkin+3.490.000
81CCL4L1chemokine (C-C motif) ligand 4-like 1Skin+3.470.000
82MELKmaternal embryonic leucine zipper kinaseBlood+3.470.000
83BUB1BBUB1 mitotic checkpoint serine/threonine kinase BBlood+3.470.000
84KYNUkynureninaseSkin+3.470.000
85CHEK1checkpoint kinase 1Blood+3.460.000
86TNFSF13Btumor necrosis factor (ligand) superfamily, member 13bSkin+3.460.000
87CCNB1cyclin B1Blood+3.450.000
88IL4I1interleukin 4 induced 1Skin+3.440.000
89TNFAIP6tumor necrosis factor, alpha-induced protein 6Skin+3.440.000
90SRGNserglycinSkin+3.440.000
91EOMESeomesoderminSkin+3.420.000
92SPP1secreted phosphoprotein 1Skin+3.400.000
93CD14CD14 moleculeSkin+3.390.000
94IL32interleukin 32Skin+3.390.000
95IFI6interferon, alpha-inducible protein 6Skin+3.390.000
96S100A9S100 calcium binding protein A9Skin+3.370.000
97PVRIGpoliovirus receptor related immunoglobulin domain containingSkin+3.350.000
98LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3Skin+3.340.000
99FAM26Ffamily with sequence similarity 26, member FSkin+3.330.000
100CXCR6chemokine (C-X-C motif) receptor 6Skin+3.330.000
101RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)Skin+3.320.000
102SULF1sulfatase 1Skin+3.310.000
103IL37interleukin 37Skin-3.310.000
104LILRA3leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3Skin+3.300.000
105CCR7chemokine (C-C motif) receptor 7Skin+3.290.000
106CORO1Acoronin, actin binding protein, 1ASkin+3.290.000
107AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase)Skin+3.290.000
108FPR1formyl peptide receptor 1Skin+3.280.000
109SLC16A3solute carrier family 16 (monocarboxylate transporter), member 3Skin+3.270.000
110CTLA4cytotoxic T-lymphocyte-associated protein 4Skin+3.270.000
111TYROBPTYRO protein tyrosine kinase binding proteinSkin+3.270.000
112IRF1interferon regulatory factor 1Skin+3.260.000
113MYO1Gmyosin IGSkin+3.260.000
114CD69CD69 moleculeSkin+3.260.000
115C2complement component 2Skin+3.240.000
116ACSBG1acyl-CoA synthetase bubblegum family member 1Skin-3.240.000
117IFIT3interferon-induced protein with tetratricopeptide repeats 3Skin+3.230.000
118SLC2A6solute carrier family 2 (facilitated glucose transporter), member 6Skin+3.220.000
119TSPAN8tetraspanin 8Skin-3.210.000
120IRF8interferon regulatory factor 8Skin+3.210.000
121TNFRSF19tumor necrosis factor receptor superfamily, member 19Skin-3.200.000
122CYBAcytochrome b-245, alpha polypeptideSkin+3.200.000
123FYBFYN binding proteinSkin+3.200.000
124KLRD1killer cell lectin-like receptor subfamily D, member 1Skin+3.180.000
125FABP7fatty acid binding protein 7, brainSkin-3.170.000
126CTSScathepsin SSkin+3.160.000
127FPR3formyl peptide receptor 3Skin+3.160.000
128NCF1Cneutrophil cytosolic factor 1C pseudogeneSkin+3.160.000
129HK3hexokinase 3 (white cell)Skin+3.140.000
130SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1Skin+3.130.000
131CCR1chemokine (C-C motif) receptor 1Skin+3.130.000
132CCL3chemokine (C-C motif) ligand 3Skin+3.130.000
133ISG20interferon stimulated exonuclease gene 20kDaSkin+3.130.000
134HAVCR2hepatitis A virus cellular receptor 2Skin+3.130.000
135SPOCK2sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2Skin+3.130.000
136CD6CD6 moleculeSkin+3.120.000
137CTSZcathepsin ZSkin+3.120.000
138SIGLEC14sialic acid binding Ig-like lectin 14Skin+3.110.000
139PI3peptidase inhibitor 3, skin-derivedSkin+3.110.001
140MT4metallothionein 4Skin-3.110.000
141FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)Skin+3.110.000
142IFI44Linterferon-induced protein 44-likeSkin+3.100.000
143PSMB9proteasome (prosome, macropain) subunit, beta type, 9Skin+3.090.000
144DEFB103Bdefensin, beta 103BSkin+3.090.000
145AIF1allograft inflammatory factor 1Skin+3.080.000
146ALDOBaldolase B, fructose-bisphosphateEpithelial Cells+3.080.000
147OASL2'-5'-oligoadenylate synthetase-likeSkin+3.080.000
148HCSThematopoietic cell signal transducerSkin+3.080.000
149HCLS1hematopoietic cell-specific Lyn substrate 1Skin+3.070.000
150CD74CD74 molecule, major histocompatibility complex, class II invariant chainSkin+3.070.000
151HAPLN3hyaluronan and proteoglycan link protein 3Skin+3.060.000
152CAMK1Gcalcium/calmodulin-dependent protein kinase IGSkin+3.050.000
153MAMDC2MAM domain containing 2Skin-3.050.000
154TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoySkin+3.050.000
155IL24interleukin 24Skin+3.040.000
156FRZBfrizzled-related proteinSkin-3.040.000
157PLIN4perilipin 4Skin-3.030.001
158HLA-DRB1major histocompatibility complex, class II, DR beta 1Skin+3.030.022
159HLA-DQA1major histocompatibility complex, class II, DQ alpha 1Skin+3.030.000
160ITGAXintegrin, alpha X (complement component 3 receptor 4 subunit)Skin+3.020.000
161PLAURplasminogen activator, urokinase receptorSkin+3.020.000
162IL18RAPinterleukin 18 receptor accessory proteinSkin+3.010.000
163CD52CD52 moleculeSkin+3.010.000

Search GEO for disease gene expression data for Dengue Disease.

Pathways for genes affiliated with Dengue Disease

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Pathways related to Dengue Disease according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9VCAM1, ICAM1
29.9ICAM1, VCAM1
39.9ICAM1, VCAM1
4
Show member pathways
9.8KRAS, RAF1
59.8KRAS, RAF1
6
Show member pathways
9.8RAF1, KRAS
79.5KRAS, ICAM1, VCAM1
8
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.5RAF1, THPO, KRAS
9
Show member pathways
RANKL/RANK Signaling Pathway36
Apoptosis and survival APRIL and BAFF signaling58
9.5ICAM1, VCAM1, RAF1
109.5RAF1, VCAM1, ICAM1
11
Show member pathways
Immune response CD16 signaling in NK cells58
9.4KRAS, RAF1, ICAM1
129.4ICAM1, RAF1, KRAS
13
Show member pathways
9.2RAF1, KRAS, SPAG9
149.2ICAM1, IL11, RAF1
15
Show member pathways
9.1KRAS, RAF1, ICAM1, VCAM1
16
Show member pathways
9.1VCAM1, RAF1, ICAM1, KRAS
17
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.9SP1, RAF1, KRAS
18
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
8.9SP1, KRAS, RAF1
19
Show member pathways
8.9KRAS, RAF1, SP1
208.9SP1, KRAS, RAF1
21
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
8.9SP1, KRAS, RAF1
22
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.7RAF1, KRAS, CD209, SP1
23
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades58
8.7VCAM1, SP1, RAF1, ICAM1
24
Show member pathways
8.4SP1, THPO, IL11, RAF1
258.3IL11, SP1, KRAS, RAF1
26
Show member pathways
7.9SPAG9, RAF1, THPO, SP1, IL11

Compounds for genes affiliated with Dengue Disease

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Compounds related to Dengue Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1polymyxin b439.9MBL2, ICAM1, VCAM1
2sodium cromoglycate439.9ICAM1, VCAM1
3cdp571439.8IL11, ICAM1
4gm-csf43 2810.6THPO, IL11, ICAM1
5budesonide43 49 1211.6ICAM1, IL11, VCAM1
6imatinib43 49 1211.5KRAS, RAF1, ICAM1, THPO
7polysaccharide439.5VCAM1, CD209, MBL2, ICAM1, THPO
8polyethylene glycol439.4IL11, THPO, ICAM1
9hyaluronic acid43 2410.3VCAM1, THPO, ICAM1, IL11
10rottlerin439.3SP1, VCAM1, RAF1
11herbimycin a43 5910.2RAF1, IL11, ICAM1, VCAM1
12hydroxyurea43 49 1211.2SP1, THPO, VCAM1
13prostacyclin439.1ICAM1, VCAM1, THPO, SP1
14fibrinogen439.1ICAM1, IL11, VCAM1, THPO, MBL2
15pdtc439.1SP1, RAF1, VCAM1, ICAM1
16sp 60012543 5910.1RAF1, ICAM1, SP1, VCAM1
17curcumin439.0SP1, VCAM1, ICAM1, RAF1
18gf 109203x43 5910.0RAF1, THPO, SP1
19tamoxifen43 49 28 1212.0VCAM1, SP1, THPO, RAF1
20histamine43 28 2411.0THPO, VCAM1, ICAM1, IL11, RAF1
21n acetylcysteine439.0SP1, VCAM1, ICAM1, RAF1
22rapamycin438.9SP1, THPO, RAF1, KRAS
23nitric oxide43 24 1210.9VCAM1, THPO, ICAM1, IL11, MBL2
24rantes438.9THPO, VCAM1, ICAM1, IL11, MBL2, CD209
25phorbol438.9RAF1, ICAM1, SP1
26tgf beta1438.9THPO, VCAM1, IL11, SP1
27sb 20358043 599.8SP1, THPO, VCAM1, RAF1, ICAM1
28troglitazone43 28 59 1211.8VCAM1, IL11, ICAM1, SP1
29pd 98,059438.8RAF1, THPO, ICAM1, SP1, VCAM1
30genistein43 28 59 2 24 1213.8RAF1, THPO, SP1, VCAM1, ICAM1
311,25 dihydroxy vitamin d3438.7SP1, RAF1, IL11
32oxygen43 249.7KRAS, MBL2, THPO, IL11, VCAM1, ICAM1
33vitamin d438.7SP1, KRAS, MBL2, IL11
34h2o2438.7RAF1, ICAM1, THPO, SP1, KRAS
35ly294002438.5SP1, VCAM1, ICAM1, RAF1, KRAS, THPO
36butyrate438.5SP1, KRAS, RAF1, IL11, THPO
37cytarabine43 49 1210.5SP1, THPO, IL11
38paclitaxel43 49 1210.5KRAS, RAF1, IL11, THPO, SP1
39pge2438.4ICAM1, RAF1, IL11, SP1, VCAM1
40oligonucleotide438.3KRAS, SP1, RAF1, THPO, IL11
41alanine438.3THPO, SP1, RAF1, IL11, VCAM1
42wortmannin438.2RAF1, KRAS, SP1, VCAM1, IL11, THPO
43cysteine438.1MBL2, SP1, THPO, VCAM1, IL11, RAF1
44estrogen437.9THPO, VCAM1, SP1, IL11, RAF1, KRAS
45phosphatidylinositol437.9KRAS, SP1, THPO, VCAM1, ICAM1, RAF1
46retinoic acid43 248.9ICAM1, KRAS, IL11, THPO, SP1, VCAM1
47serine437.8VCAM1, SP1, IL11, RAF1, KRAS, MBL2
48dexamethasone43 49 28 1210.7SP1, MBL2, VCAM1, ICAM1, IL11, RAF1
49vegf437.6THPO, RAF1, MBL2, IL11, ICAM1, VCAM1
50tyrosine436.8MBL2, THPO, VCAM1, ICAM1, SPAG9, RAF1

GO Terms for genes affiliated with Dengue Disease

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Cellular components related to Dengue Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.4IL11, CSPG5, MBL2, CD209, PRNT
2extracellular spaceGO:00056158.4MBL2, IL11, ICAM1, VCAM1, THPO

Biological processes related to Dengue Disease according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:00226149.9VCAM1, ICAM1
2cellular response to glucose stimulusGO:00713339.9ICAM1, VCAM1
3leukocyte cell-cell adhesionGO:00071599.8CD209, ICAM1, VCAM1
4heterophilic cell-cell adhesionGO:00071579.7CD209, ICAM1, VCAM1
5striated muscle cell differentiationGO:00511469.5KRAS, SPAG9
6cytokine-mediated signaling pathwayGO:00192219.2VCAM1, ICAM1, KRAS
7megakaryocyte differentiationGO:00302199.0IL11, SP1
8innate immune responseGO:00450878.9CLEC5A, RAF1, KRAS, MBL2, CD209

Molecular functions related to Dengue Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mannose bindingGO:00055379.8CD209, MBL2
2virus receptor activityGO:00016189.7ICAM1, CLEC5A
3growth factor activityGO:00080838.8CSPG5, IL11, THPO

Products for genes affiliated with Dengue Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Dengue Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet