MCID: DNG003
MIFTS: 58

Dengue Disease malady

Infectious diseases category

Summaries for Dengue Disease

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8Disease Ontology, 33MedlinePlus, 3CDC, 32MalaCards
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MedlinePlus:33 Dengue is an infection caused by a virus. you can get it if an infected mosquito bites you. dengue does not spread from person to person. it is common in warm, wet areas of the world. outbreaks occur in the rainy season. dengue is rare in the united states. symptoms include a high fever, headaches, joint and muscle pain, vomiting, and a rash. in some cases, dengue turns into dengue hemorrhagic fever, which causes bleeding from your nose, gums, or under your skin. it can also become dengue shock syndrome, which causes massive bleeding and shock. these forms of dengue are life-threatening. there is no specific treatment. most people with dengue recover within 2 weeks. until then, drinking lots of fluids, resting and taking non-aspirin fever-reducing medicines might help. people with the more severe forms of dengue usually need to go to the hospital and get fluids. to lower your risk when traveling in dengue-prone countries wear insect repellent with deet wear clothes that cover your arms, legs and feet close unscreened doors and windows nih: national institute of allergy and infectious diseases

MalaCards: Dengue Disease, also known as dengue fever, is related to yellow fever and malaria, and has symptoms including rash, severe headache and severe pain behind the eyes. An important gene associated with Dengue Disease is CD209 (CD209 molecule), and among its related pathways are HTLV-I infection and Rheumatoid arthritis. The compounds cycloheximide and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone, and related mouse phenotypes are vision/eye and homeostasis/metabolism.

Disease Ontology:8 A viral infectious disease that results in infection, has material basis in dengue virus [ncbitaxon:12637] with four serotypes (dengue virus 1, 2, 3 and 4), which are transmitted by aedes mosquito bite. the infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.

CDC:3 With more than one-third of the world’s population living in areas at risk for infection, dengue virus is a leading cause of illness and death in the tropics and subtropics. As many as 400 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are not yet any vaccines to prevent infection with dengue virus and the most effective protective measures are those that avoid mosquito bites. When infected, early recognition and prompt supportive treatment can substantially lower the risk of medical complications and death.

Aliases & Classifications for Dengue Disease

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Sources:
42NIH Rare Diseases, 60UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

dengue disease 8 10
dengue fever 8 42 60
dengue hemorrhagic fever 42 60
dengue shock syndrome 42 60
dengue 44 33
philippine hemorrhagic fever 42
singapore hemorrhagic fever 42
hemorrhagic dengue 42
breakbone fever 8
classic dengue 8


External Ids:

Disease Ontology8 DOID:12205
MeSH34 D003715
ICD9CM27 061
NCIt39 C34528
ICD1025 A90

Related Diseases for Dengue Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dengue Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1yellow fever30.9CSPG5, PRNT, RAF1, KRAS
2malaria30.5ICAM1, TNF
3aspergillosis30.4MBL2
4encephalitis30.4RAF1, VCAM1
5encephalomyelitis30.4VCAM1, TNF
6west nile encephalitis30.4RAF1
7hepatitis30.2KRAS, RAF1
8lupus erythematosus30.2F3
9purpura30.2THPO
10kawasaki disease30.2MBL2
11peritonitis30.2TNF
12hypertension30.2VCAM1, ICAM1
13disseminated intravascular coagulation30.2THPO, F3
14pneumonia30.2IL11, TNF, MBL2, ICAM1
15systemic lupus erythematosus30.2ICAM1, MBL2, TNF, F3, VCAM1
16leukemia30.2ICAM1, MBL2, TNF, IL11, RAF1, THPO
17respiratory failure30.1ICAM1, TNF, F3
18tick-borne encephalitis30.0RAF1
19neutropenia30.0MBL2, IL11, THPO
20acute leukemia30.0IL11, THPO, KRAS
21pancreatitis30.0KRAS, IL11, ICAM1
22hepatitis c30.0CD209, RAF1, THPO, KRAS
23thrombocytosis30.0IL11, F3, THPO
24vasculitis30.0ICAM1, MBL2, TNF, VCAM1
25tuberculosis30.0SP1, IL11, CD209, TNF, MBL2
26murray valley encephalitis29.9RAF1
27influenza29.9IL11, MBL2
28thrombocytopenia29.9IL11, F3, RAF1, THPO
29thyroiditis29.7MBL2
30sickle cell disease29.7VCAM1
31acute myocardial infarction29.7F3
32cerebral malaria29.7ICAM1, TNF
33myeloma29.7VCAM1, IL11, ICAM1
34glomerulonephritis29.7VCAM1, MBL2, ICAM1
35myeloid leukemia29.7IL11, RAF1, THPO, SP1
36chronic myeloid leukemia29.7IL11, RAF1, THPO, KRAS
37myocardial infarction29.7SP1, F3, IL11
38melanoma29.7SP1, VCAM1, KRAS, RAF1, TNF, ICAM1
39acalculous cholecystitis10.4
40cholecystitis10.4
41dengue fever, protection against10.4
42pituitary apoplexy10.3
43acute myocarditis10.3
44compartment syndrome10.3
45invasive aspergillosis10.3
46leptospirosis10.3
47acute disseminated encephalomyelitis10.3
48chikungunya10.3
49myositis10.2
50plasmodium malariae malaria10.2

Graphical network of the top 20 diseases related to Dengue Disease:



Diseases related to dengue disease

Clinical Features for Dengue Disease

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Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 7)
  • rash
  • severe headache
  • severe pain behind the eyes
  • joint pain
  • muscle
  • mild bleeding
  • fever

Drugs & Therapeutics for Dengue Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dengue Disease

Drug clinical trials:

Search ClinicalTrials for Dengue Disease

Search NIH Clinical Center for Dengue Disease

Search CenterWatch for Dengue Disease

Genetic Tests for Dengue Disease

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Anatomical Context for Dengue Disease

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32MalaCards
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MalaCards organs/tissues related to Dengue Disease:

32
Eye, Skin, Bone, Liver, Endothelial, Nk cells, Monocytes, Testes

Animal Models for Dengue Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Dengue Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.2RAF1
2MP:00053768.6SP1, VCAM1, CD209, MBL2, ICAM1
3MP:00107718.4RAF1, KRAS, SPAG9, SP1
4MP:00053877.8VCAM1, ICAM1, MBL2, TNF, CD209, CLEC5A
5MP:00053977.7ICAM1, MBL2, TNF, F3, RAF1, THPO

Publications for Dengue Disease

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Sources:
50PubMed
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Articles related to Dengue Disease:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Dogma in classifying dengue disease. (23926138)
2013
2
Epidemiological trends of dengue disease in Brazil (2000-2010): a systematic literature search and analysis. (24386496)
2013
3
Knowledge, attitude, and practice of dengue disease among healthcare professionals in southern Taiwan. (23332425)
2013
4
An optimal control problem arising from a dengue disease transmission model. (23274179)
2013
5
Atypical presentations of dengue disease in the elderly visiting the ED. (23399333)
2013
6
Fatal dengue in patients with sickle cell disease or sickle cell anemia in CuraAsao: two case reports. (23951370)
2013
7
Comment on: "Atypical presentations of dengue disease in the elderly visiting the ED" (24342867)
2013
8
Can non-human primates serve as models for investigating dengue disease pathogenesis? (24130557)
2013
9
Surge of dengue virus infection and chikungunya Fever in bali in 2010: the burden of mosquito-borne infectious diseases in a tourist destination. (23874141)
2013
10
Temporal patterns and a disease forecasting model of dengue hemorrhagic fever in Jakarta based on 10 years of surveillance data. (23691630)
2013
11
Assessing weather effects on dengue disease in malaysia. (24287855)
2013
12
Simple Prognostic Criteria can Definitively Identify Patients who Develop Severe Versus Non-Severe Dengue Disease, or Have Other Febrile Illnesses. (22383925)
2012
13
Elevated serum levels of high mobility group box 1 (HMGB1) protein in dengue-infected patients are associated with disease symptoms and secondary infection. (22884669)
2012
14
Infectious disease emergencies in returning travelers: special reference to malaria, dengue fever, and chikungunya. (23102486)
2012
15
Association of human immune response to Aedes aegypti salivary proteins with dengue disease severity. (21995849)
2012
16
Virus role during intraepidemic increase in dengue disease severity. (21254883)
2011
17
Evaluation of the traditional and revised WHO classifications of Dengue disease severity. (22087348)
2011
18
Characterization of early host responses in adults with dengue disease. (21810247)
2011
19
Clinical and virological factors influencing the performance of a NS1 antigen-capture assay and potential use as a marker of dengue disease severity. (21811645)
2011
20
Changing trends of dengue disease: a brief report from a tertiary care hospital in New Delhi. (21503411)
2011
21
Dengue disease status in Chennai (2006-2008): a retrospective analysis. (21441688)
2011
22
Markers of dengue disease severity. (19802579)
2010
23
Characteristic of dengue disease in Taiwan: 2002-2007. (20348527)
2010
24
A BALB/c mouse model shows that liver involvement in dengue disease is immune-mediated. (20673760)
2010
25
Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease. (20153282)
2010
26
Stochastic eco-epidemiological model of dengue disease transmission by Aedes aegypti mosquito. (19861133)
2010
27
Dengue disease. (20954580)
2010
28
CLEC5A is critical for dengue-virus-induced lethal disease. (18496526)
2008
29
Describing the geographic spread of dengue disease by traveling waves. (18590749)
2008
30
What does dengue disease surveillance contribute to predicting and detecting outbreaks and describing trends? (18768080)
2008
31
NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease. (16412060)
2006
32
Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease. (16951817)
2006
33
Evidence of vascular damage in dengue disease: demonstration of high levels of soluble cell adhesion molecules and circulating endothelial cells. (17090406)
2006
34
A variant in the CD209 (DC-SIGN) promoter is associated with severity of dengue disease]. (16274635)
2005
35
A variant in the CD209 promoter is associated with severity of dengue disease. (15838506)
2005
36
Association of increased platelet-associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections. (15498040)
2004
37
Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999. (12641411)
2003
38
Immunology and immunopathogenesis of dengue disease. (14689699)
2003
39
Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections. (11825945)
2002
40
HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais. (12472660)
2002
41
Concomitant dengue hemorrhagic fever with Kawasaki disease. (11023092)
2000
42
Influence of vertical and mechanical transmission on the dynamics of dengue disease. (10942786)
2000
43
Surveillance for an emerging disease: dengue hemorrhagic fever in Puerto Rico, 1988-1997. Puerto Rico Association of Epidemiologists. (10730300)
1999
44
A model for dengue disease with variable human population. (10220925)
1999
45
Analysis of a dengue disease transmission model. (9656647)
1998
46
Growth of dengue type 2 virus isolates in human peripheral blood leukocytes correlates with severe and mild dengue disease. (1951875)
1991
47
Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorrhagic fever. (6754243)
1981
48
Fatal hemorrhagic disease and shock associated with primary dengue infection on a Pacific island. (4150910)
1974
49
Observations related to pathogenesis of dengue hemorrhagic fever. 3. Virologic studies of fatal disease. (5419205)
1970
50
Observations related to the pathogenesis of dengue hemorrhagic fever. II. Antigenic and biologic properties of dengue viruses and their association with disease response in the host. (5464392)
1970

Genetic Variations for Dengue Disease

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Expression for genes affiliated with Dengue Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dengue Disease

Search GEO for disease gene expression data for Dengue Disease.

Pathways for genes affiliated with Dengue Disease

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Sources:
29KEGG, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 49PharmGKB, 4Cell Signaling Technology
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Pathways related to Dengue Disease according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2KRAS
210.0IL11
3
Hide members
9.9KRAS, RAF1
4
Hide members
9.7VCAM1, RAF1, ICAM1
59.7ICAM1, RAF1, VCAM1
69.7KRAS, RAF1, ICAM1
79.7VCAM1, TNF, ICAM1
89.7VCAM1, TNF, ICAM1
99.7VCAM1, TNF, ICAM1
109.7VCAM1, TNF, ICAM1
119.7ICAM1, TNF, VCAM1
12
Hide members
9.6SP1, THPO
13
Hide members
9.6SP1, RAF1
149.4RAF1, IL11, ICAM1
15
Hide members
9.4ICAM1, RAF1, KRAS, VCAM1
16
Hide members
9.4ICAM1, RAF1, KRAS, VCAM1
17
Hide members
9.4ICAM1, TNF, CD209, RAF1
189.4TNF, IL11, THPO
19
Hide members
9.4KRAS, THPO, RAF1, F3
20
Hide members
9.4TNF, CD209, RAF1, KRAS
21
Hide members
9.4TNF, RAF1, THPO, KRAS
22
Hide members
9.4ICAM1, TNF, RAF1, KRAS
23
Hide members
9.3SP1, KRAS, RAF1
249.1SPAG9, KRAS, RAF1
258.5SP1, KRAS, RAF1, IL11, TNF
26
Hide members
7.7TNF, IL11, RAF1, THPO, SPAG9, SP1

Compounds for genes affiliated with Dengue Disease

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 2BitterDB, 24HMDB
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Compounds related to Dengue Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5RAF1
2pentoxifylline44 1111.3F3, VCAM1
3butyrate4410.2THPO, IL11
4n-tosyl-l-phenylalanine chloromethyl ketone4410.0F3, ICAM1, TNF
5apocynin44 5910.9TNF, VCAM1, ICAM1
6okt3449.9TNF, VCAM1, ICAM1
7groalpha449.9ICAM1, TNF, VCAM1
8polymyxin b449.9ICAM1, MBL2, VCAM1, TNF
9dexamethasone44 49 28 1112.8CD209, SP1, RAF1
10parthenolide44 210.8ICAM1, TNF, VCAM1
11cdp571449.8IL11, TNF, ICAM1
12carbohydrates449.7MBL2, CD209, F3, VCAM1
138-isoprostane449.7TNF, ICAM1, VCAM1
14iloprost44 59 28 1112.6F3, VCAM1, THPO
15gm-csf44 2810.6THPO, TNF, IL11, ICAM1
16budesonide44 49 1111.6VCAM1, TNF, ICAM1, IL11
17cyclophosphamide44 49 1111.5IL11, MBL2, F3
18serine449.5SP1, KRAS, TNF
19polysaccharide449.4THPO, VCAM1, ICAM1, CD209, MBL2, F3
20ciglitazone44 2810.4SP1, TNF, ICAM1
21rantes449.4TNF, ICAM1, THPO, IL11, MBL2
22herbimycin a44 5910.3VCAM1, TNF, IL11, RAF1, ICAM1
23endotoxin449.2IL11, TNF, ICAM1, F3, VCAM1
24oxygen44 2410.2KRAS, IL11, MBL2, ICAM1, TNF
25curcumin449.1ICAM1, RAF1, VCAM1, SP1, TNF
26simvastatin44 49 59 28 11 2414.1VCAM1, F3, TNF, ICAM1, SP1
27n acetylcysteine449.1TNF, ICAM1, SP1, RAF1, VCAM1
28paclitaxel44 49 1111.1IL11, RAF1, KRAS, SP1
29histamine44 28 2411.0THPO, RAF1, IL11, ICAM1, TNF, VCAM1
30quercetin44 59 11 2412.0SP1, F3, RAF1, VCAM1
31actinomycin d449.0F3, THPO, SP1, ICAM1, TNF
32prostacyclin448.9TNF, F3, THPO, VCAM1, SP1, ICAM1
33tgf beta1448.9SP1, TNF, VCAM1, THPO, IL11
34hyaluronic acid44 249.9THPO, ICAM1, VCAM1, IL11
35pd 98,059448.9TNF, ICAM1, RAF1, THPO, VCAM1, SP1
36troglitazone44 28 59 1111.9IL11, TNF, VCAM1, ICAM1, SP1
37pdtc448.9ICAM1, SP1, VCAM1, RAF1, F3, TNF
38sp 60012544 599.9TNF, VCAM1, SP1, ICAM1, F3, RAF1
39genistein44 28 59 2 11 2413.9VCAM1, ICAM1, TNF, SP1, RAF1, THPO
40fibrinogen448.8VCAM1, THPO, IL11, TNF, MBL2, ICAM1
41h2o2448.8KRAS, TNF, RAF1, ICAM1, SP1, THPO
42ly294002448.7ICAM1, TNF, THPO, KRAS, VCAM1, SP1
43wortmannin448.7KRAS, THPO, VCAM1, RAF1, IL11, SP1
44sb 20358044 599.7F3, RAF1, THPO, VCAM1, SP1, ICAM1
45phosphatidylinositol448.4RAF1, VCAM1, KRAS, SP1, THPO, ICAM1
46estrogen448.4VCAM1, KRAS, SP1, THPO, RAF1, IL11
47cysteine448.4MBL2, VCAM1, THPO, SP1, RAF1, F3
48retinoic acid44 248.9RAF1, F3, SP1, ICAM1, TNF, THPO
49vegf447.7RAF1, KRAS, VCAM1, SP1, F3, IL11
50tyrosine447.2VCAM1, SP1, SPAG9, THPO, RAF1, CD209

GO Terms for genes affiliated with Dengue Disease

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Sources:
16Gene Ontology
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Cellular components related to Dengue Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.9VCAM1, F3, CLEC5A, TNF, MBL2
2extracellular spaceGO:0056158.1VCAM1, ICAM1, MBL2, TNF, IL11, F3

Biological processes related to Dengue Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.2VCAM1, ICAM1
2leukocyte cell-cell adhesionGO:00715910.0VCAM1, CD209, ICAM1
3heterophilic cell-cell adhesionGO:00715710.0VCAM1, CD209, ICAM1
4negative regulation of growth of symbiont in hostGO:0441309.9TNF, MBL2
5leukocyte tethering or rollingGO:0509019.8VCAM1, TNF
6MAPK cascadeGO:0001659.8TNF, RAF1, KRAS
7positive regulation of peptidyl-serine phosphorylationGO:0331389.6RAF1, IL11, TNF
8megakaryocyte differentiationGO:0302199.4SP1, IL11
9striated muscle cell differentiationGO:0511469.4SPAG9, KRAS
10positive regulation of NF-kappaB transcription factor activityGO:0510929.3KRAS, TNF, ICAM1
11innate immune responseGO:0450879.0MBL2, CD209, CLEC5A, RAF1, KRAS
12modulation by virus of host morphology or physiologyGO:0190488.9ICAM1, CD209, CLEC5A, VCAM1, SP1

Molecular functions related to Dengue Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mannose bindingGO:00553710.0CD209, MBL2

Products for genes affiliated with Dengue Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dengue Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet