MCID: DNG003
MIFTS: 52

Dengue Disease malady

Infectious category

Summaries for Dengue Disease

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 33MalaCards
See all sources

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MedlinePlus:34 Dengue is an infection caused by a virus. you can get it if an infected mosquito bites you. dengue does not spread from person to person. it is common in warm, wet areas of the world. outbreaks occur in the rainy season. dengue is rare in the united states. symptoms include a high fever, headaches, joint and muscle pain, vomiting, and a rash. in some cases, dengue turns into dengue hemorrhagic fever, which causes bleeding from your nose, gums, or under your skin. it can also become dengue shock syndrome, which causes massive bleeding and shock. these forms of dengue are life-threatening. there is no specific treatment. most people with dengue recover within 2 weeks. until then, drinking lots of fluids, resting and taking non-aspirin fever-reducing medicines might help. people with the more severe forms of dengue usually need to go to the hospital and get fluids. to lower your risk when traveling in dengue-prone countries wear insect repellent with deet wear clothes that cover your arms, legs and feet close unscreened doors and windows nih: national institute of allergy and infectious diseases

MalaCards: Dengue Disease, also known as dengue fever, is related to yellow fever and nephritis, and has symptoms including fever, joint pain and rash. An important gene associated with Dengue Disease is CD209 (CD209 molecule), and among its related pathways are HTLV-I infection and Rheumatoid arthritis. The compounds cycloheximide and pentoxifylline have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and homeostasis/metabolism.

Disease Ontology:8 A viral infectious disease that results in infection, has material basis in dengue virus [ncbitaxon:12637] with four serotypes (dengue virus 1, 2, 3 and 4), which are transmitted by aedes mosquito bite. the infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.

CDC:3 With more than one-third of the world’s population living in areas at risk for infection, dengue virus is a leading cause of illness and death in the tropics and subtropics. As many as 400 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are not yet any vaccines to prevent infection with dengue virus and the most effective protective measures are those that avoid mosquito bites. When infected, early recognition and prompt supportive treatment can substantially lower the risk of medical complications and death.

Aliases & Classifications for Dengue Disease

Sources:
43NIH Rare Diseases, 61UMLS, 8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

dengue disease 8 10
dengue fever 8 43 61
dengue hemorrhagic fever 43 61
dengue shock syndrome 43 61
dengue 45 34
philippine hemorrhagic fever 43
singapore hemorrhagic fever 43
hemorrhagic dengue 43
breakbone fever 8
classic dengue 8


External Ids:

Disease Ontology8 DOID:12205
MeSH35 D003715
ICD9CM27 061
NCIt40 C34528
ICD1025 A90

Related Diseases for Dengue Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Dengue Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1yellow fever30.9CSPG5, PRNT, RAF1, KRAS
2nephritis30.4CD209, VCAM1
3aspergillosis30.4MBL2
4lupus nephritis30.4ICAM1, MBL2, VCAM1
5west nile encephalitis30.4RAF1
6kawasaki disease30.3MBL2
7hepatitis c30.3CD209, RAF1, THPO, KRAS
8systemic lupus erythematosus30.3ICAM1, MBL2, TNF, F3, VCAM1
9vasculitis30.3ICAM1, MBL2, TNF, VCAM1
10tick-borne encephalitis30.1RAF1
11acute leukemia30.1IL11, THPO, KRAS
12thrombocytosis30.0IL11, F3, THPO
13tuberculosis30.0SP1, IL11, CD209, TNF, MBL2
14murray valley encephalitis30.0RAF1
15thrombocytopenia29.9IL11, F3, RAF1, THPO
16thyroiditis29.7MBL2
17sickle cell disease29.7VCAM1
18acute myocardial infarction29.7F3
19cerebral malaria29.7ICAM1, TNF
20chronic myeloid leukemia29.7IL11, RAF1, THPO, KRAS
21septic shock29.7F3, TNF, MBL2
22sepsis29.7MBL2, TNF, IL11, F3
23n syndrome10.7
24viral hemorrhagic fever10.6
25west nile virus10.5
26char syndrome10.5
27acute pancreatitis10.4
28adult syndrome10.4
29dengue fever, protection against10.4
30acalculous cholecystitis10.4
31pituitary apoplexy10.4
32acute myocarditis10.4
33leptospirosis10.3
34chikungunya10.3
35invasive aspergillosis10.3
36myelitis10.2
37scrub typhus10.2
38typhus10.2
39guillain-barr� syndrome10.2
40acute liver failure10.2
41diabetic ketoacidosis10.2
42brazilian hemorrhagic fever10.2
43japanese encephalitis10.2
44acute disseminated encephalomyelitis10.2
45acquired immunodeficiency syndrome10.2
46femoral neuropathy10.2
47typhoid fever10.2
48hantavirus pulmonary syndrome10.2
49hepatitis a10.2
50b cell deficiency10.2

Graphical network of the top 20 diseases related to Dengue Disease:



Diseases related to dengue disease

Clinical Features for Dengue Disease

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 7)
  • fever
  • joint pain
  • rash
  • severe headache
  • severe pain behind the eyes
  • muscle
  • mild bleeding

Drugs & Therapeutics for Dengue Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Dengue Disease

Drug clinical trials:

Search ClinicalTrials for Dengue Disease

Search NIH Clinical Center for Dengue Disease

Search CenterWatch for Dengue Disease

Genetic Tests for Dengue Disease

Anatomical Context for Dengue Disease

Animal Models for Dengue Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Dengue Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.2RAF1
2MP:00053768.6SP1, VCAM1, CD209, MBL2, ICAM1
3MP:00107718.4RAF1, KRAS, SPAG9, SP1
4MP:00053877.8VCAM1, ICAM1, MBL2, TNF, CD209, CLEC5A
5MP:00053977.7ICAM1, MBL2, TNF, F3, RAF1, THPO

Publications for Dengue Disease

Sources:
51PubMed
See all sources

Articles related to Dengue Disease:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Association between proinflammatory cytokines and lipid peroxidation in patients with severe dengue disease around defervescence. (24216294)
2014
2
Epidemiological trends of dengue disease in Brazil (2000-2010): a systematic literature search and analysis. (24386496)
2013
3
The battle between infection and host immune responses of dengue virus and its implication in dengue disease pathogenesis. (23476150)
2013
4
Assessing weather effects on dengue disease in malaysia. (24287855)
2013
5
Environmental influences on antibody-enhanced dengue disease outcomes. (23295753)
2012
6
Association of human immune response to Aedes aegypti salivary proteins with dengue disease severity. (21995849)
2012
7
Unfolded protein response (UPR) gene expression during antibody-dependent enhanced infection of cultured monocytes correlates with dengue disease severity. (20858223)
2011
8
Biosensors and rapid diagnostic tests on the frontier between analytical and clinical chemistry for biomolecular diagnosis of dengue disease: a review. (21241843)
2011
9
Evaluation of the traditional and revised WHO classifications of Dengue disease severity. (22087348)
2011
10
Molecular mimicry between virus and host and its implications for dengue disease pathogenesis. (21502191)
2011
11
Characterization of early host responses in adults with dengue disease. (21810247)
2011
12
Clinical and virological factors influencing the performance of a NS1 antigen-capture assay and potential use as a marker of dengue disease severity. (21811645)
2011
13
Changing trends of dengue disease: a brief report from a tertiary care hospital in New Delhi. (21503411)
2011
14
Influence of environmental conditions on asynchronous outbreaks of dengue disease and increasing vector population in Kaohsiung, Taiwan. (21424970)
2011
15
Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity. (22190239)
2011
16
Markers of dengue disease severity. (19802579)
2010
17
Characteristic of dengue disease in Taiwan: 2002-2007. (20348527)
2010
18
Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease. (20153282)
2010
19
Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification. (20168989)
2010
20
HLA and other gene associations with dengue disease severity. (19802581)
2010
21
Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators. (20689812)
2010
22
Understanding the contribution of cellular immunity to dengue disease pathogenesis. (18837790)
2008
23
What does dengue disease surveillance contribute to predicting and detecting outbreaks and describing trends? (18768080)
2008
24
Blood group AB is associated with increased risk for severe dengue disease in secondary infections. (17330792)
2007
25
HLA-A, -B, -C, and -DRB1 allele frequencies in Cuban individuals with antecedents of dengue 2 disease: advantages of the Cuban population for HLA studies of dengue virus infection. (17509453)
2007
26
Dengue disease severity in Indonesian children: an evaluation of the World Health Organization classification system. (17386105)
2007
27
NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease. (16412060)
2006
28
Relationship of thrombopoietin and interleukin-11 levels to thrombocytopenia associated with dengue disease. (16759877)
2006
29
Activated peripheral lymphocytes with increased expression of cell adhesion molecules and cytotoxic markers are associated with dengue fever disease. (16951817)
2006
30
Tropical Diseases Lacking Adequate Control Measures: Dengue, Leishmaniasis, and African Trypanosomiasis (21250331)
2006
31
Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. (16407359)
2006
32
Genetic variations and relationship among dengue virus type 3 strains isolated from patients with mild or severe form of dengue disease in Indonesia and Thailand. (16438144)
2005
33
A variant in the CD209 promoter is associated with severity of dengue disease. (15838506)
2005
34
Association of increased platelet-associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections. (15498040)
2004
35
Virological interpretations of dengue disease spectrum in infants in Chennai, Tamil Nadu, India, need reevaluation. (15131236)
2004
36
Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999. (12641411)
2003
37
Dengue disease spectrum among infants in the 2001 dengue epidemic in Chennai, Tamil Nadu, India. (12904418)
2003
38
HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais. (12472660)
2002
39
Concomitant dengue hemorrhagic fever with Kawasaki disease. (11023092)
2000
40
A model for dengue disease with variable human population. (10220925)
1999
41
Dengue: a re-emerging disease. A clinical and epidemiological study in 57 Spanish travelers]. (9859093)
1998
42
Growth of dengue type 2 virus isolates in human peripheral blood leukocytes correlates with severe and mild dengue disease. (1951875)
1991
43
Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorrhagic fever. (6754243)
1981
44
Type 1 dengue with hemorrhagic disease in Fiji: epidemiologic findings. (889018)
1977
45
Fatal hemorrhagic disease and shock associated with primary dengue infection on a Pacific island. (4150910)
1974
46
Immunological surveys of arbovirus infections in South-East Asia, with special reference to dengue, chikungunya, and Kyasanur Forest disease. (4400821)
1971
47
Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. (5419206)
1970
48
Observations related to pathogenesis of dengue hemorrhagic fever. 3. Virologic studies of fatal disease. (5419205)
1970
49
Observations related to the pathogenesis of dengue hemorrhagic fever. II. Antigenic and biologic properties of dengue viruses and their association with disease response in the host. (5464392)
1970
50
RECENT EPIDEMICS OF HEMORRHAGIC FEVER IN THAILAND. OBSERVATIONS RELATED TO PATHOGENESIS OF A "NEW" DENGUE DISEASE. (14334760)
1965

Genetic Variations for Dengue Disease

Expression for genes affiliated with Dengue Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dengue Disease

Search GEO for disease gene expression data for Dengue Disease.

Pathways for genes affiliated with Dengue Disease

Sources:
30KEGG, 54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems, 50PharmGKB, 4Cell Signaling Technology
See all sources

Pathways related to Dengue Disease according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2KRAS
210.0IL11
3
Hide members
9.9KRAS, RAF1
4
Hide members
9.7VCAM1, RAF1, ICAM1
59.7ICAM1, RAF1, VCAM1
69.7KRAS, RAF1, ICAM1
79.7VCAM1, TNF, ICAM1
89.7VCAM1, TNF, ICAM1
99.7VCAM1, TNF, ICAM1
109.7VCAM1, TNF, ICAM1
119.7ICAM1, TNF, VCAM1
12
Hide members
9.6SP1, THPO
13
Hide members
9.6SP1, RAF1
149.4RAF1, IL11, ICAM1
15
Hide members
9.4ICAM1, RAF1, KRAS, VCAM1
16
Hide members
9.4ICAM1, RAF1, KRAS, VCAM1
17
Hide members
9.4ICAM1, TNF, CD209, RAF1
189.4TNF, IL11, THPO
19
Hide members
9.4KRAS, THPO, RAF1, F3
20
Hide members
9.4TNF, CD209, RAF1, KRAS
21
Hide members
9.4TNF, RAF1, THPO, KRAS
22
Hide members
9.4ICAM1, TNF, RAF1, KRAS
23
Hide members
9.3SP1, KRAS, RAF1
249.1SPAG9, KRAS, RAF1
258.5SP1, KRAS, RAF1, IL11, TNF
26
Hide members
7.7TNF, IL11, RAF1, THPO, SPAG9, SP1

Compounds for genes affiliated with Dengue Disease

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 2BitterDB, 24HMDB
See all sources

Compounds related to Dengue Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5RAF1
2pentoxifylline45 1111.3VCAM1, F3
3butyrate4510.2THPO, IL11
4n-tosyl-l-phenylalanine chloromethyl ketone4510.0F3, TNF, ICAM1
5apocynin45 6010.9VCAM1, TNF, ICAM1
6groalpha459.9ICAM1, TNF, VCAM1
7okt3459.9ICAM1, TNF, VCAM1
8polymyxin b459.9ICAM1, MBL2, TNF, VCAM1
9dexamethasone45 50 29 1112.8SP1, RAF1, CD209
10cdp571459.8ICAM1, TNF, IL11
11parthenolide45 210.8ICAM1, TNF, VCAM1
12carbohydrates459.7VCAM1, F3, CD209, MBL2
138-isoprostane459.7VCAM1, TNF, ICAM1
14iloprost45 60 29 1112.6VCAM1, THPO, F3
15gm-csf45 2910.6THPO, IL11, TNF, ICAM1
16budesonide45 50 1111.6ICAM1, TNF, IL11, VCAM1
17cyclophosphamide45 50 1111.5MBL2, IL11, F3
18serine459.5SP1, KRAS, TNF
19ciglitazone45 2910.4ICAM1, TNF, SP1
20polysaccharide459.4ICAM1, MBL2, CD209, F3, THPO, VCAM1
21rantes459.4ICAM1, MBL2, TNF, IL11, THPO
22herbimycin a45 6010.3ICAM1, TNF, IL11, RAF1, VCAM1
23endotoxin459.2ICAM1, TNF, IL11, F3, VCAM1
24oxygen45 2410.2ICAM1, MBL2, TNF, IL11, KRAS
25curcumin459.1ICAM1, TNF, RAF1, VCAM1, SP1
26simvastatin45 50 60 29 11 2414.1ICAM1, TNF, F3, VCAM1, SP1
27n acetylcysteine459.1ICAM1, TNF, RAF1, VCAM1, SP1
28paclitaxel45 50 1111.1IL11, RAF1, KRAS, SP1
29histamine45 29 2411.0ICAM1, TNF, IL11, RAF1, THPO, VCAM1
30quercetin45 60 11 2412.0F3, RAF1, VCAM1, SP1
31actinomycin d459.0ICAM1, TNF, F3, THPO, SP1
32prostacyclin458.9ICAM1, TNF, F3, THPO, VCAM1, SP1
33tgf beta1458.9TNF, IL11, THPO, VCAM1, SP1
34hyaluronic acid45 249.9ICAM1, IL11, THPO, VCAM1
35pd 98,059458.9ICAM1, TNF, RAF1, THPO, VCAM1, SP1
36troglitazone45 29 60 1111.9ICAM1, TNF, IL11, VCAM1, SP1
37pdtc458.9ICAM1, TNF, F3, RAF1, VCAM1, SP1
38sp 60012545 609.9ICAM1, TNF, F3, RAF1, VCAM1, SP1
39genistein45 29 60 2 11 2413.9ICAM1, TNF, RAF1, THPO, VCAM1, SP1
40fibrinogen458.8ICAM1, MBL2, TNF, IL11, F3, THPO
41h2o2458.8ICAM1, TNF, RAF1, THPO, KRAS, SP1
42ly294002458.7ICAM1, TNF, RAF1, THPO, KRAS, VCAM1
43wortmannin458.7IL11, RAF1, THPO, KRAS, VCAM1, SP1
44sb 20358045 609.7ICAM1, TNF, F3, RAF1, THPO, VCAM1
45phosphatidylinositol458.4ICAM1, IL11, RAF1, THPO, KRAS, VCAM1
46estrogen458.4MBL2, IL11, RAF1, THPO, KRAS, VCAM1
47cysteine458.4MBL2, IL11, F3, RAF1, THPO, VCAM1
48retinoic acid45 248.9ICAM1, TNF, IL11, F3, RAF1, THPO
49vegf457.7SP1, ICAM1, MBL2, TNF, IL11, F3
50tyrosine457.2ICAM1, MBL2, CD209, IL11, RAF1, THPO

GO Terms for genes affiliated with Dengue Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Dengue Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.9VCAM1, F3, CLEC5A, TNF, MBL2
2extracellular spaceGO:0056158.1VCAM1, ICAM1, MBL2, TNF, IL11, F3

Biological processes related to Dengue Disease according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.2VCAM1, ICAM1
2leukocyte cell-cell adhesionGO:00715910.0VCAM1, CD209, ICAM1
3heterophilic cell-cell adhesionGO:00715710.0VCAM1, CD209, ICAM1
4negative regulation of growth of symbiont in hostGO:0441309.9TNF, MBL2
5leukocyte tethering or rollingGO:0509019.8VCAM1, TNF
6MAPK cascadeGO:0001659.8TNF, RAF1, KRAS
7positive regulation of peptidyl-serine phosphorylationGO:0331389.6RAF1, IL11, TNF
8megakaryocyte differentiationGO:0302199.4SP1, IL11
9striated muscle cell differentiationGO:0511469.4SPAG9, KRAS
10positive regulation of NF-kappaB transcription factor activityGO:0510929.3KRAS, TNF, ICAM1
11innate immune responseGO:0450879.0MBL2, CD209, CLEC5A, RAF1, KRAS
12modulation by virus of host morphology or physiologyGO:0190488.9ICAM1, CD209, CLEC5A, VCAM1, SP1

Molecular functions related to Dengue Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mannose bindingGO:00553710.0CD209, MBL2

Products for genes affiliated with Dengue Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dengue Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet