MCID: DNG003
MIFTS: 59

Dengue Disease malady

Rare diseases, Infectious diseases categories
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Summaries for Dengue Disease

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Sources:
8Disease Ontology, 34MedlinePlus, 4CDC, 33MalaCards
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MedlinePlus:34 Dengue is an infection caused by a virus. you can get it if an infected mosquito bites you. dengue does not spread from person to person. it is common in warm, wet areas of the world. outbreaks occur in the rainy season. dengue is rare in the united states. symptoms include a high fever, headaches, joint and muscle pain, vomiting, and a rash. in some cases, dengue turns into dengue hemorrhagic fever, which causes bleeding from your nose, gums, or under your skin. it can also become dengue shock syndrome, which causes massive bleeding and shock. these forms of dengue are life-threatening. there is no specific treatment. most people with dengue recover within 2 weeks. until then, drinking lots of fluids, resting and taking non-aspirin fever-reducing medicines might help. people with the more severe forms of dengue usually need to go to the hospital and get fluids. to lower your risk when traveling in dengue-prone countries wear insect repellent with deet wear clothes that cover your arms, legs and feet close unscreened doors and windows nih: national institute of allergy and infectious diseases

MalaCards: Dengue Disease, also known as dengue fever, is related to yellow fever and malaria, and has symptoms including rash, severe headache and severe pain behind the eyes. An important gene associated with Dengue Disease is CD209 (CD209 molecule), and among its related pathways are African trypanosomiasis and LDL Oxidation in Atherogenesis. The compounds polymyxin b and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone, and related mouse phenotypes are integument and immune system.

Disease Ontology:8 A viral infectious disease that results in infection, has material basis in dengue virus [ncbitaxon:12637] with four serotypes (dengue virus 1, 2, 3 and 4), which are transmitted by aedes mosquito bite. the infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.

CDC:4 With more than one-third of the world’s population living in areas at risk for infection, dengue virus is a leading cause of illness and death in the tropics and subtropics. As many as 400 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are not yet any vaccines to prevent infection with dengue virus and the most effective protective measures are those that avoid mosquito bites. When infected, early recognition and prompt supportive treatment can substantially lower the risk of medical complications and death.

Aliases & Classifications for Dengue Disease

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Aliases & Descriptions:

dengue disease 8 10
dengue fever 8 43 62
dengue hemorrhagic fever 43 62
dengue shock syndrome 43 62
dengue 45 34
philippine hemorrhagic fever 43
singapore hemorrhagic fever 43
thai hemorrhagic fever 43
hemorrhagic dengue 43
breakbone fever 8
classic dengue 8


External Ids:

Disease Ontology8 DOID:12205
MeSH35 D003715
NCIt40 C34528
ICD9CM27 061
ICD1025 A90

Related Diseases for Dengue Disease

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17GeneCards, 18GeneDecks
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Diseases related to Dengue Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1yellow fever30.9PRNT, CSPG5, RAF1, KRAS
2malaria30.7ICAM1
3lupus nephritis30.5VCAM1, ICAM1, MBL2
4pneumonia30.4ICAM1, IL11, MBL2
5systemic lupus erythematosus30.3MBL2, ICAM1, VCAM1
6tick-borne encephalitis30.3RAF1
7thrombocytosis30.2THPO, IL11
8neutropenia30.2MBL2, IL11, THPO
9vasculitis30.2MBL2, ICAM1, VCAM1
10aplastic anemia30.1IL11, THPO
11tuberculosis30.1SP1, IL11, MBL2, CD209
12pancreatitis30.1ICAM1, IL11, KRAS
13leukemia30.1SP1, THPO, ICAM1, IL11, RAF1, KRAS
14hepatitis c30.0THPO, RAF1, KRAS, CD209
15thyroiditis29.9MBL2
16thrombocytopenia29.9RAF1, IL11, THPO
17cerebral malaria29.9ICAM1, VCAM1
18glomerulonephritis29.8VCAM1, ICAM1, MBL2
19myeloma29.8VCAM1, ICAM1, IL11
20myeloid leukemia29.7SP1, THPO, IL11, RAF1
21chronic myeloid leukemia29.7THPO, IL11, RAF1, KRAS
22melanoma29.6SP1, VCAM1, ICAM1, RAF1, KRAS
23west nile virus10.5
24acalculous cholecystitis10.5
25cholecystitis10.5
26pituitary apoplexy10.4
27compartment syndrome10.4
28leptospirosis10.3
29chikungunya10.3
30encephalitis10.3
31nephritis10.3
32aspergillosis10.3
33myositis10.2
34myelitis10.2
35hepatitis10.2
36lupus erythematosus10.2
37typhus10.2
38diabetic ketoacidosis10.2
39acquired immunodeficiency syndrome10.2
40duodenitis10.2
41kawasaki disease10.2
42hantavirus pulmonary syndrome10.2
43acute myocarditis10.2
44filariasis10.2
45gingivitis10.2
46neuropathy10.2
47peritonitis10.2
48proteinuria10.2
49purpura10.2
50thalassemia10.2

Graphical network of the top 20 diseases related to Dengue Disease:



Diseases related to dengue disease

Symptoms for Dengue Disease

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 7)
  • rash
  • severe headache
  • severe pain behind the eyes
  • joint pain
  • muscle
  • mild bleeding
  • fever

Drugs & Therapeutics for Dengue Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Dengue Disease

Search NIH Clinical Center for Dengue Disease

Genetic Tests for Dengue Disease

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Anatomical Context for Dengue Disease

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33MalaCards
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MalaCards organs/tissues related to Dengue Disease:

33
Eye, Skin, Bone, Liver, Endothelial, Nk cells, Monocytes, Testes

Animal Models for Dengue Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Dengue Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1KRAS, RAF1, ICAM1, SP1, SPAG9
2MP:00053877.9CD209, THPO, CLEC5A, VCAM1, ICAM1, RAF1
3MP:00053977.7SP1, THPO, VCAM1, ICAM1, RAF1, KRAS
4MP:00053767.5SP1, VCAM1, ICAM1, RAF1, KRAS, MBL2

Publications for Dengue Disease

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Sources:
52PubMed
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Articles related to Dengue Disease:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Association between proinflammatory cytokines and lipid peroxidation in patients with severe dengue disease around defervescence. (24216294)
2014
2
Dogma in classifying dengue disease. (23926138)
2013
3
Epidemiological trends of dengue disease in Brazil (2000-2010): a systematic literature search and analysis. (24386496)
2013
4
The battle between infection and host immune responses of dengue virus and its implication in dengue disease pathogenesis. (23476150)
2013
5
Knowledge, attitude, and practice of dengue disease among healthcare professionals in southern Taiwan. (23332425)
2013
6
An optimal control problem arising from a dengue disease transmission model. (23274179)
2013
7
Atypical presentations of dengue disease in the elderly visiting the ED. (23399333)
2013
8
Comment on: "Atypical presentations of dengue disease in the elderly visiting the ED" (24342867)
2013
9
Can non-human primates serve as models for investigating dengue disease pathogenesis? (24130557)
2013
10
Simple Prognostic Criteria can Definitively Identify Patients who Develop Severe Versus Non-Severe Dengue Disease, or Have Other Febrile Illnesses. (22383925)
2012
11
Environmental influences on antibody-enhanced dengue disease outcomes. (23295753)
2012
12
Association of human immune response to Aedes aegypti salivary proteins with dengue disease severity. (21995849)
2012
13
Unfolded protein response (UPR) gene expression during antibody-dependent enhanced infection of cultured monocytes correlates with dengue disease severity. (20858223)
2011
14
Biosensors and rapid diagnostic tests on the frontier between analytical and clinical chemistry for biomolecular diagnosis of dengue disease: a review. (21241843)
2011
15
Virus role during intraepidemic increase in dengue disease severity. (21254883)
2011
16
Evaluation of the traditional and revised WHO classifications of Dengue disease severity. (22087348)
2011
17
Molecular mimicry between virus and host and its implications for dengue disease pathogenesis. (21502191)
2011
18
Characterization of early host responses in adults with dengue disease. (21810247)
2011
19
Clinical and virological factors influencing the performance of a NS1 antigen-capture assay and potential use as a marker of dengue disease severity. (21811645)
2011
20
Changing trends of dengue disease: a brief report from a tertiary care hospital in New Delhi. (21503411)
2011
21
Influence of environmental conditions on asynchronous outbreaks of dengue disease and increasing vector population in Kaohsiung, Taiwan. (21424970)
2011
22
Dengue disease status in Chennai (2006-2008): a retrospective analysis. (21441688)
2011
23
Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity. (22190239)
2011
24
Markers of dengue disease severity. (19802579)
2010
25
Characteristic of dengue disease in Taiwan: 2002-2007. (20348527)
2010
26
A BALB/c mouse model shows that liver involvement in dengue disease is immune-mediated. (20673760)
2010
27
Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease. (20153282)
2010
28
Stochastic eco-epidemiological model of dengue disease transmission by Aedes aegypti mosquito. (19861133)
2010
29
Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification. (20168989)
2010
30
Dengue disease. (20954580)
2010
31
HLA and other gene associations with dengue disease severity. (19802581)
2010
32
Understanding the contribution of cellular immunity to dengue disease pathogenesis. (18837790)
2008
33
Describing the geographic spread of dengue disease by traveling waves. (18590749)
2008
34
What does dengue disease surveillance contribute to predicting and detecting outbreaks and describing trends? (18768080)
2008
35
Blood group AB is associated with increased risk for severe dengue disease in secondary infections. (17330792)
2007
36
Dengue disease severity in Indonesian children: an evaluation of the World Health Organization classification system. (17386105)
2007
37
NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease. (16412060)
2006
38
Relationship of thrombopoietin and interleukin-11 levels to thrombocytopenia associated with dengue disease. (16759877)
2006
39
Evidence of vascular damage in dengue disease: demonstration of high levels of soluble cell adhesion molecules and circulating endothelial cells. (17090406)
2006
40
Genetic variations and relationship among dengue virus type 3 strains isolated from patients with mild or severe form of dengue disease in Indonesia and Thailand. (16438144)
2005
41
A variant in the CD209 (DC-SIGN) promoter is associated with severity of dengue disease]. (16274635)
2005
42
A variant in the CD209 promoter is associated with severity of dengue disease. (15838506)
2005
43
Virological interpretations of dengue disease spectrum in infants in Chennai, Tamil Nadu, India, need reevaluation. (15131236)
2004
44
Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999. (12641411)
2003
45
Immunology and immunopathogenesis of dengue disease. (14689699)
2003
46
Dengue disease spectrum among infants in the 2001 dengue epidemic in Chennai, Tamil Nadu, India. (12904418)
2003
47
Influence of vertical and mechanical transmission on the dynamics of dengue disease. (10942786)
2000
48
A model for dengue disease with variable human population. (10220925)
1999
49
Analysis of a dengue disease transmission model. (9656647)
1998
50
RECENT EPIDEMICS OF HEMORRHAGIC FEVER IN THAILAND. OBSERVATIONS RELATED TO PATHOGENESIS OF A "NEW" DENGUE DISEASE. (14334760)
1965

Variations for Dengue Disease

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Expression for genes affiliated with Dengue Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dengue Disease

Search GEO for disease gene expression data for Dengue Disease.

Pathways for genes affiliated with Dengue Disease

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Sources:
50PathCards, 30KEGG, 53QIAGEN, 60Thomson Reuters, 55Reactome, 54R&D Systems, 38NCBI BioSystems Database, 5Cell Signaling Technology, 51PharmGKB
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Pathways related to Dengue Disease according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9VCAM1, ICAM1
29.9VCAM1, ICAM1
39.9VCAM1, ICAM1
4
Show member pathways
9.8KRAS, RAF1
5
Show member pathways
9.8KRAS, RAF1
69.8RAF1, KRAS
79.5KRAS, ICAM1, VCAM1
8
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.5THPO, RAF1, KRAS
9
Show member pathways
RANKL/RANK Signaling Pathway38
Apoptosis and survival APRIL and BAFF signaling60
9.5VCAM1, ICAM1, RAF1
109.5RAF1, ICAM1, VCAM1
119.4KRAS, RAF1, ICAM1
12
Show member pathways
Immune response CD16 signaling in NK cells60
9.4ICAM1, RAF1, KRAS
13
Show member pathways
9.2KRAS, RAF1, SPAG9
149.2ICAM1, IL11, RAF1
15
Show member pathways
9.1VCAM1, ICAM1, RAF1, KRAS
16
Show member pathways
9.1VCAM1, ICAM1, RAF1, KRAS
17
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.9KRAS, RAF1, SP1
18
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
8.9KRAS, RAF1, SP1
19
Show member pathways
8.9KRAS, RAF1, SP1
208.9SP1, RAF1, KRAS
21
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
8.9KRAS, RAF1, SP1
22
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.7SP1, RAF1, KRAS, CD209
23
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
8.7RAF1, ICAM1, VCAM1, SP1
24
Show member pathways
8.4RAF1, IL11, THPO, SP1
258.3SP1, IL11, RAF1, KRAS
26
Show member pathways
7.9SPAG9, SP1, THPO, IL11, RAF1

Compounds for genes affiliated with Dengue Disease

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Dengue Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1polymyxin b459.9MBL2, ICAM1, VCAM1
2sodium cromoglycate459.9ICAM1, VCAM1
3cdp571459.8IL11, ICAM1
4gm-csf45 2910.6THPO, IL11, ICAM1
5budesonide45 51 1111.6ICAM1, IL11, VCAM1
6imatinib45 51 1111.5KRAS, RAF1, ICAM1, THPO
7polysaccharide459.5VCAM1, CD209, MBL2, ICAM1, THPO
8polyethylene glycol459.4IL11, THPO, ICAM1
9hyaluronic acid45 2410.3VCAM1, THPO, ICAM1, IL11
10rottlerin459.3SP1, VCAM1, RAF1
11herbimycin a45 6110.2RAF1, IL11, ICAM1, VCAM1
12hydroxyurea45 51 1111.2SP1, THPO, VCAM1
13prostacyclin459.1ICAM1, VCAM1, THPO, SP1
14fibrinogen459.1ICAM1, IL11, VCAM1, THPO, MBL2
15pdtc459.1SP1, RAF1, VCAM1, ICAM1
16sp 60012545 6110.1RAF1, ICAM1, SP1, VCAM1
17curcumin459.0SP1, VCAM1, ICAM1, RAF1
18gf 109203x45 6110.0RAF1, THPO, SP1
19tamoxifen45 51 29 1112.0VCAM1, SP1, THPO, RAF1
20histamine45 29 2411.0THPO, VCAM1, ICAM1, IL11, RAF1
21n acetylcysteine459.0SP1, VCAM1, ICAM1, RAF1
22rapamycin458.9SP1, THPO, RAF1, KRAS
23nitric oxide45 24 1110.9VCAM1, THPO, ICAM1, IL11, MBL2
24rantes458.9THPO, VCAM1, ICAM1, IL11, MBL2, CD209
25phorbol458.9RAF1, ICAM1, SP1
26tgf beta1458.9THPO, VCAM1, IL11, SP1
27sb 20358045 619.8SP1, THPO, VCAM1, RAF1, ICAM1
28troglitazone45 29 61 1111.8VCAM1, IL11, ICAM1, SP1
29pd 98,059458.8RAF1, THPO, ICAM1, SP1, VCAM1
30genistein45 29 61 3 24 1113.8RAF1, THPO, SP1, VCAM1, ICAM1
311,25 dihydroxy vitamin d3458.7SP1, RAF1, IL11
32oxygen45 249.7KRAS, MBL2, THPO, IL11, VCAM1, ICAM1
33vitamin d458.7SP1, KRAS, MBL2, IL11
34h2o2458.7RAF1, ICAM1, THPO, SP1, KRAS
35ly294002458.5SP1, VCAM1, ICAM1, RAF1, KRAS, THPO
36butyrate458.5SP1, KRAS, RAF1, IL11, THPO
37cytarabine45 51 1110.5SP1, THPO, IL11
38paclitaxel45 51 1110.5KRAS, RAF1, IL11, THPO, SP1
39pge2458.4ICAM1, RAF1, IL11, SP1, VCAM1
40oligonucleotide458.3KRAS, SP1, RAF1, THPO, IL11
41alanine458.3THPO, SP1, RAF1, IL11, VCAM1
42wortmannin458.2RAF1, KRAS, SP1, VCAM1, IL11, THPO
43cysteine458.1MBL2, SP1, THPO, VCAM1, IL11, RAF1
44estrogen457.9THPO, VCAM1, SP1, IL11, RAF1, KRAS
45phosphatidylinositol457.9KRAS, SP1, THPO, VCAM1, ICAM1, RAF1
46retinoic acid45 248.9ICAM1, KRAS, IL11, THPO, SP1, VCAM1
47serine457.8VCAM1, SP1, IL11, RAF1, KRAS, MBL2
48dexamethasone45 51 29 1110.7SP1, MBL2, VCAM1, ICAM1, IL11, RAF1
49vegf457.6THPO, RAF1, MBL2, IL11, ICAM1, VCAM1
50tyrosine456.8MBL2, THPO, VCAM1, ICAM1, SPAG9, RAF1

GO Terms for genes affiliated with Dengue Disease

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Sources:
16Gene Ontology
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Cellular components related to Dengue Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4IL11, CSPG5, MBL2, CD209, PRNT
2extracellular spaceGO:0056158.4MBL2, IL11, ICAM1, VCAM1, THPO

Biological processes related to Dengue Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:0226149.9VCAM1, ICAM1
2cellular response to glucose stimulusGO:0713339.9ICAM1, VCAM1
3leukocyte cell-cell adhesionGO:0071599.8CD209, ICAM1, VCAM1
4heterophilic cell-cell adhesionGO:0071579.7CD209, ICAM1, VCAM1
5striated muscle cell differentiationGO:0511469.5KRAS, SPAG9
6cytokine-mediated signaling pathwayGO:0192219.2VCAM1, ICAM1, KRAS
7megakaryocyte differentiationGO:0302199.0IL11, SP1
8innate immune responseGO:0450878.9CLEC5A, RAF1, KRAS, MBL2, CD209

Molecular functions related to Dengue Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mannose bindingGO:0055379.8CD209, MBL2
2virus receptor activityGO:0016189.7ICAM1, CLEC5A
3growth factor activityGO:0080838.8CSPG5, IL11, THPO

Products for genes affiliated with Dengue Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dengue Disease

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet