MCID: DNG003
MIFTS: 60

Dengue Disease malady

Rare diseases, Infectious diseases categories
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Summaries for Dengue Disease

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MedlinePlus:33 Dengue is an infection caused by a virus. you can get it if an infected mosquito bites you. dengue does not spread from person to person. it is common in warm, wet areas of the world. outbreaks occur in the rainy season. dengue is rare in the united states. symptoms include a high fever, headaches, joint and muscle pain, vomiting, and a rash. in some cases, dengue turns into dengue hemorrhagic fever, which causes bleeding from your nose, gums, or under your skin. it can also become dengue shock syndrome, which causes massive bleeding and shock. these forms of dengue are life-threatening. there is no specific treatment. most people with dengue recover within 2 weeks. until then, drinking lots of fluids, resting and taking non-aspirin fever-reducing medicines might help. people with the more severe forms of dengue usually need to go to the hospital and get fluids. to lower your risk when traveling in dengue-prone countries wear insect repellent with deet wear clothes that cover your arms, legs and feet close unscreened doors and windows nih: national institute of allergy and infectious diseases

MalaCards based summary: Dengue Disease, also known as dengue fever, is related to malaria and pancreatitis, and has symptoms including An important gene associated with Dengue Disease is CD209 (CD209 molecule), and among its related pathways are African trypanosomiasis and LDL Oxidation in Atherogenesis. The compounds polymyxin b and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and skin, and related mouse phenotypes are integument and immune system.

Disease Ontology:8 A viral infectious disease that results in infection, has material basis in dengue virus [ncbitaxon:12637] with four serotypes (dengue virus 1, 2, 3 and 4), which are transmitted by aedes mosquito bite. the infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding.

CDC:3 With more than one-third of the world’s population living in areas at risk for infection, dengue virus is a leading cause of illness and death in the tropics and subtropics. As many as 400 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are not yet any vaccines to prevent infection with dengue virus and the most effective protective measures are those that avoid mosquito bites. When infected, early recognition and prompt supportive treatment can substantially lower the risk of medical complications and death.

Aliases & Classifications for Dengue Disease

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Dengue Disease, Aliases & Descriptions:

Name: Dengue Disease 30 8 10
Dengue Fever 8 42 62
Philippine Hemorrhagic Fever 42 62
Singapore Hemorrhagic Fever 42 62
Dengue Hemorrhagic Fever 42 62
Thai Hemorrhagic Fever 42 62
 
Dengue Shock Syndrome 42 62
Breakbone Fever 8 62
Dengue 44 33
Hemorrhagic Dengue 42
Classic Dengue 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


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Disease Ontology8 DOID:12205
ICD9CM27 061
NCIt39 C34528
MeSH34 D003715
ICD1025 A90

Related Diseases for Dengue Disease

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Diseases related to Dengue Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1malaria30.9ICAM1
2pancreatitis30.8ICAM1, IL11, KRAS
3yellow fever30.8RAF1, CSPG5, PRNT, KRAS
4tick-borne encephalitis30.8RAF1
5lupus nephritis30.7ICAM1, MBL2, VCAM1
6neutropenia30.7THPO, MBL2, IL11
7vasculitis30.5ICAM1, VCAM1, MBL2
8pneumonia30.5IL11, MBL2, ICAM1
9thyroiditis30.5MBL2
10thrombocytosis30.4IL11, THPO
11aplastic anemia30.4THPO, IL11
12systemic lupus erythematosus30.2MBL2, ICAM1, VCAM1
13cerebral malaria30.1VCAM1, ICAM1
14tuberculosis30.1SP1, IL11, MBL2, CD209
15thrombocytopenia30.1RAF1, THPO, IL11
16glomerulonephritis30.0VCAM1, ICAM1, MBL2
17acute lymphoblastic leukemia29.9SP1, KRAS, THPO
18hepatitis c29.9KRAS, RAF1, THPO, CD209
19myeloma29.7VCAM1, ICAM1, IL11
20myeloid leukemia29.7RAF1, SP1, THPO, IL11
21chronic myeloid leukemia29.5THPO, KRAS, RAF1, IL11
22leukemia29.2THPO, SP1, ICAM1, IL11, RAF1, KRAS
23melanoma29.0KRAS, ICAM1, VCAM1, RAF1, SP1
24hepatitis10.6
25west nile virus10.5
26acute pancreatitis10.5
27pituitary apoplexy10.5
28myocarditis10.5
29acalculous cholecystitis10.4
30cholecystitis10.4
31compartment syndrome10.4
32acquired thrombocytopenia10.4IL11, THPO
33autoimmune thrombocytopenic purpura10.3THPO, IL11
34megakaryocytic leukemia10.3IL11, THPO
35leptospirosis10.3
36chikungunya10.3
37nephritis10.3
38aspergillosis10.3
39refractory anemia10.3IL11, THPO
40hemorrhagic thrombocythemia10.3THPO, IL11
41cardiofaciocutaneous syndrome10.3KRAS
42arteriosclerosis obliterans10.3ICAM1, VCAM1
43immunoglobulin a vasculitis10.3VCAM1, ICAM1
44inclusion body myositis10.3ICAM1, VCAM1
45rheumatoid vasculitis10.3ICAM1, VCAM1
46leukostasis10.3VCAM1, ICAM1
47myelofibrosis10.3IL11, THPO
48oral lichen planus10.3VCAM1, ICAM1
49myositis10.3
50vernal keratoconjunctivitis10.3ICAM1, VCAM1

Graphical network of the top 20 diseases related to Dengue Disease:



Diseases related to dengue disease

Symptoms for Dengue Disease

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Drugs & Therapeutics for Dengue Disease

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Drug clinical trials:

Search ClinicalTrials for Dengue Disease

Search NIH Clinical Center for Dengue Disease

Genetic Tests for Dengue Disease

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Anatomical Context for Dengue Disease

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MalaCards organs/tissues related to Dengue Disease:

32
Eye, Bone, Skin, Liver, Nk cells, Endothelial, Testes, Monocytes, T cells

Animal Models for Dengue Disease or affiliated genes

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MGI Mouse Phenotypes related to Dengue Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1KRAS, RAF1, ICAM1, SP1, SPAG9
2MP:00053877.9CD209, THPO, CLEC5A, VCAM1, ICAM1, RAF1
3MP:00053977.7SP1, THPO, VCAM1, ICAM1, RAF1, KRAS
4MP:00053767.5SP1, VCAM1, ICAM1, RAF1, KRAS, MBL2

Publications for Dengue Disease

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Articles related to Dengue Disease:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
CD8+ T cells prevent antigen-induced antibody-dependent enhancement of dengue disease in mice. (25217165)
2014
2
Evaluation of the WHO classification of dengue disease severity during an epidemic in 2011 in the state of CearA!, Brazil. (24626308)
2014
3
Epidemiological trends of dengue disease in Mexico (2000-2011): a systematic literature search and analysis. (25375162)
2014
4
Dengue disease surveillance: an updated systematic literature review. (24889501)
2014
5
Association between proinflammatory cytokines and lipid peroxidation in patients with severe dengue disease around defervescence. (24216294)
2014
6
Epidemiology of Dengue Disease in the Philippines (2000-2011): A Systematic Literature Review. (25375119)
2014
7
First experimental in vivo model of enhanced dengue disease severity through maternally acquired heterotypic dengue antibodies. (24699622)
2014
8
Dengue disease outbreak detection. (25160360)
2014
9
Predictive symptoms and signs of severe dengue disease for patients with dengue fever: a meta-analysis. (25097856)
2014
10
Dengue disease surveillance: improving data for dengue control. (25375232)
2014
11
Epidemiology of dengue disease in malaysia (2000-2012): a systematic literature review. (25375211)
2014
12
Reviewing the literature for epidemiological trends of dengue disease: introduction to a series of seven national systematic literature reviews. (25375830)
2014
13
Dogma in classifying dengue disease. (23926138)
2013
14
Epidemiological trends of dengue disease in Brazil (2000-2010): a systematic literature search and analysis. (24386496)
2013
15
The battle between infection and host immune responses of dengue virus and its implication in dengue disease pathogenesis. (23476150)
2013
16
Knowledge, attitude, and practice of dengue disease among healthcare professionals in southern Taiwan. (23332425)
2013
17
An optimal control problem arising from a dengue disease transmission model. (23274179)
2013
18
Atypical presentations of dengue disease in the elderly visiting the ED. (23399333)
2013
19
Comment on: "Atypical presentations of dengue disease in the elderly visiting the ED" (24342867)
2013
20
Can non-human primates serve as models for investigating dengue disease pathogenesis? (24130557)
2013
21
Assessing weather effects on dengue disease in malaysia. (24287855)
2013
22
Simple Prognostic Criteria can Definitively Identify Patients who Develop Severe Versus Non-Severe Dengue Disease, or Have Other Febrile Illnesses. (22383925)
2012
23
Environmental influences on antibody-enhanced dengue disease outcomes. (23295753)
2012
24
Unfolded protein response (UPR) gene expression during antibody-dependent enhanced infection of cultured monocytes correlates with dengue disease severity. (20858223)
2011
25
Biosensors and rapid diagnostic tests on the frontier between analytical and clinical chemistry for biomolecular diagnosis of dengue disease: a review. (21241843)
2011
26
Virus role during intraepidemic increase in dengue disease severity. (21254883)
2011
27
Evaluation of the traditional and revised WHO classifications of Dengue disease severity. (22087348)
2011
28
Molecular mimicry between virus and host and its implications for dengue disease pathogenesis. (21502191)
2011
29
Characterization of early host responses in adults with dengue disease. (21810247)
2011
30
Clinical and virological factors influencing the performance of a NS1 antigen-capture assay and potential use as a marker of dengue disease severity. (21811645)
2011
31
Changing trends of dengue disease: a brief report from a tertiary care hospital in New Delhi. (21503411)
2011
32
Influence of environmental conditions on asynchronous outbreaks of dengue disease and increasing vector population in Kaohsiung, Taiwan. (21424970)
2011
33
Markers of dengue disease severity. (19802579)
2010
34
Characteristic of dengue disease in Taiwan: 2002-2007. (20348527)
2010
35
A BALB/c mouse model shows that liver involvement in dengue disease is immune-mediated. (20673760)
2010
36
Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease. (20153282)
2010
37
Stochastic eco-epidemiological model of dengue disease transmission by Aedes aegypti mosquito. (19861133)
2010
38
Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification. (20168989)
2010
39
Understanding the contribution of cellular immunity to dengue disease pathogenesis. (18837790)
2008
40
Describing the geographic spread of dengue disease by traveling waves. (18590749)
2008
41
What does dengue disease surveillance contribute to predicting and detecting outbreaks and describing trends? (18768080)
2008
42
Blood group AB is associated with increased risk for severe dengue disease in secondary infections. (17330792)
2007
43
NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease. (16412060)
2006
44
Relationship of thrombopoietin and interleukin-11 levels to thrombocytopenia associated with dengue disease. (16759877)
2006
45
Genetic variations and relationship among dengue virus type 3 strains isolated from patients with mild or severe form of dengue disease in Indonesia and Thailand. (16438144)
2005
46
Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999. (12641411)
2003
47
Immunology and immunopathogenesis of dengue disease. (14689699)
2003
48
Dengue disease spectrum among infants in the 2001 dengue epidemic in Chennai, Tamil Nadu, India. (12904418)
2003
49
A model for dengue disease with variable human population. (10220925)
1999
50
Analysis of a dengue disease transmission model. (9656647)
1998

Variations for Dengue Disease

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Expression for genes affiliated with Dengue Disease

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Expression patterns in normal tissues for genes affiliated with Dengue Disease

Search GEO for disease gene expression data for Dengue Disease.

Pathways for genes affiliated with Dengue Disease

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Pathways related to Dengue Disease according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9VCAM1, ICAM1
29.9VCAM1, ICAM1
39.9VCAM1, ICAM1
4
Show member pathways
9.8KRAS, RAF1
5
Show member pathways
9.8KRAS, RAF1
69.8RAF1, KRAS
79.5KRAS, ICAM1, VCAM1
8
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.5THPO, RAF1, KRAS
9
Show member pathways
RANKL/RANK Signaling Pathway37
Apoptosis and survival APRIL and BAFF signaling60
9.5VCAM1, ICAM1, RAF1
109.5RAF1, ICAM1, VCAM1
119.4KRAS, RAF1, ICAM1
12
Show member pathways
Immune response CD16 signaling in NK cells60
9.4ICAM1, RAF1, KRAS
13
Show member pathways
9.2KRAS, RAF1, SPAG9
149.2ICAM1, IL11, RAF1
15
Show member pathways
9.1VCAM1, ICAM1, RAF1, KRAS
16
Show member pathways
9.1VCAM1, ICAM1, RAF1, KRAS
17
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.9KRAS, RAF1, SP1
18
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
8.9KRAS, RAF1, SP1
19
Show member pathways
8.9KRAS, RAF1, SP1
208.9SP1, RAF1, KRAS
21
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
8.9KRAS, RAF1, SP1
22
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.7SP1, RAF1, KRAS, CD209
23
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
8.7RAF1, ICAM1, VCAM1, SP1
24
Show member pathways
8.4RAF1, IL11, THPO, SP1
258.3SP1, IL11, RAF1, KRAS
26
Show member pathways
7.9SPAG9, SP1, THPO, IL11, RAF1

Compounds for genes affiliated with Dengue Disease

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Compounds related to Dengue Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1polymyxin b449.9MBL2, ICAM1, VCAM1
2sodium cromoglycate449.9ICAM1, VCAM1
3cdp571449.8IL11, ICAM1
4gm-csf44 2810.6THPO, IL11, ICAM1
5budesonide44 50 1111.6ICAM1, IL11, VCAM1
6imatinib44 50 1111.5KRAS, RAF1, ICAM1, THPO
7polysaccharide449.5VCAM1, CD209, MBL2, ICAM1, THPO
8polyethylene glycol449.4IL11, THPO, ICAM1
9hyaluronic acid44 2410.3VCAM1, THPO, ICAM1, IL11
10rottlerin449.3SP1, VCAM1, RAF1
11herbimycin a44 6110.2RAF1, IL11, ICAM1, VCAM1
12hydroxyurea44 50 1111.2SP1, THPO, VCAM1
13prostacyclin449.1ICAM1, VCAM1, THPO, SP1
14fibrinogen449.1ICAM1, IL11, VCAM1, THPO, MBL2
15pdtc449.1SP1, RAF1, VCAM1, ICAM1
16sp 60012544 6110.1RAF1, ICAM1, SP1, VCAM1
17curcumin449.0SP1, VCAM1, ICAM1, RAF1
18gf 109203x44 6110.0RAF1, THPO, SP1
19tamoxifen44 50 28 1112.0VCAM1, SP1, THPO, RAF1
20histamine44 28 2411.0THPO, VCAM1, ICAM1, IL11, RAF1
21n acetylcysteine449.0SP1, VCAM1, ICAM1, RAF1
22rapamycin448.9SP1, THPO, RAF1, KRAS
23nitric oxide44 24 1110.9VCAM1, THPO, ICAM1, IL11, MBL2
24rantes448.9THPO, VCAM1, ICAM1, IL11, MBL2, CD209
25phorbol448.9RAF1, ICAM1, SP1
26tgf beta1448.9THPO, VCAM1, IL11, SP1
27sb 20358044 619.8SP1, THPO, VCAM1, RAF1, ICAM1
28troglitazone44 28 61 1111.8VCAM1, IL11, ICAM1, SP1
29pd 98,059448.8RAF1, THPO, ICAM1, SP1, VCAM1
30genistein44 28 61 2 24 1113.8RAF1, THPO, SP1, VCAM1, ICAM1
311,25 dihydroxy vitamin d3448.7SP1, RAF1, IL11
32oxygen44 249.7KRAS, MBL2, THPO, IL11, VCAM1, ICAM1
33vitamin d448.7SP1, KRAS, MBL2, IL11
34h2o2448.7RAF1, ICAM1, THPO, SP1, KRAS
35ly294002448.5SP1, VCAM1, ICAM1, RAF1, KRAS, THPO
36butyrate448.5SP1, KRAS, RAF1, IL11, THPO
37cytarabine44 50 1110.5SP1, THPO, IL11
38paclitaxel44 50 1110.5KRAS, RAF1, IL11, THPO, SP1
39pge2448.4ICAM1, RAF1, IL11, SP1, VCAM1
40oligonucleotide448.3KRAS, SP1, RAF1, THPO, IL11
41alanine448.3THPO, SP1, RAF1, IL11, VCAM1
42wortmannin448.2RAF1, KRAS, SP1, VCAM1, IL11, THPO
43cysteine448.1MBL2, SP1, THPO, VCAM1, IL11, RAF1
44estrogen447.9THPO, VCAM1, SP1, IL11, RAF1, KRAS
45phosphatidylinositol447.9KRAS, SP1, THPO, VCAM1, ICAM1, RAF1
46retinoic acid44 248.9ICAM1, KRAS, IL11, THPO, SP1, VCAM1
47serine447.8VCAM1, SP1, IL11, RAF1, KRAS, MBL2
48dexamethasone44 50 28 1110.7SP1, MBL2, VCAM1, ICAM1, IL11, RAF1
49vegf447.6THPO, RAF1, MBL2, IL11, ICAM1, VCAM1
50tyrosine446.8MBL2, THPO, VCAM1, ICAM1, SPAG9, RAF1

GO Terms for genes affiliated with Dengue Disease

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Cellular components related to Dengue Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4IL11, CSPG5, MBL2, CD209, PRNT
2extracellular spaceGO:0056158.4MBL2, IL11, ICAM1, VCAM1, THPO

Biological processes related to Dengue Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:0226149.9VCAM1, ICAM1
2cellular response to glucose stimulusGO:0713339.9ICAM1, VCAM1
3leukocyte cell-cell adhesionGO:0071599.8CD209, ICAM1, VCAM1
4heterophilic cell-cell adhesionGO:0071579.7CD209, ICAM1, VCAM1
5striated muscle cell differentiationGO:0511469.5KRAS, SPAG9
6cytokine-mediated signaling pathwayGO:0192219.2VCAM1, ICAM1, KRAS
7megakaryocyte differentiationGO:0302199.0IL11, SP1
8innate immune responseGO:0450878.9CLEC5A, RAF1, KRAS, MBL2, CD209

Molecular functions related to Dengue Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mannose bindingGO:0055379.8CD209, MBL2
2virus receptor activityGO:0016189.7ICAM1, CLEC5A
3growth factor activityGO:0080838.8CSPG5, IL11, THPO

Products for genes affiliated with Dengue Disease

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  • Antibodies
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Sources for Dengue Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet