DHF
MCID: DNG002
MIFTS: 49

Dengue Hemorrhagic Fever (DHF) malady

Infectious diseases category
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Summaries for Dengue Hemorrhagic Fever

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8Disease Ontology, 4CDC, 33MalaCards
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CDC:4 With more than one-third of the world’s population living in areas at risk for infection, dengue virus is a leading cause of illness and death in the tropics and subtropics. As many as 400 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are not yet any vaccines to prevent infection with dengue virus and the most effective protective measures are those that avoid mosquito bites. When infected, early recognition and prompt supportive treatment can substantially lower the risk of medical complications and death.

MalaCards: Dengue Hemorrhagic Fever, also known as DHF, is related to dengue disease and japanese encephalitis, and has symptoms including reduction in the fluid part of the blood, hemorrhagic lesions of the skin and thrombocytopenia. An important gene associated with Dengue Hemorrhagic Fever is LTA (lymphotoxin alpha), and among its related pathways are IL2 signaling events mediated by PI3K and IL4-mediated signaling events. The compounds okt3 and neopterin have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and t cells.

Disease Ontology:8 A dengue disease that occurs when a person experiences a second infection with a heterologous dengue virus serotype, which is transmitted by aedes mosquito bite. the infection has symptom hemorrhagic lesions of the skin, has symptom thrombocytopenia, has symptom reduction in the fluid part of the blood, and has symptom high fever.

Aliases & Classifications for Dengue Hemorrhagic Fever

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8Disease Ontology, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

dengue hemorrhagic fever 8 45 62
dhf 8


External Ids:

Disease Ontology8 DOID:12206
NCIt40 C34683
MeSH35 D019595
ICD1025 A91

Related Diseases for Dengue Hemorrhagic Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Dengue Hemorrhagic Fever:



Diseases related to dengue hemorrhagic fever

Symptoms for Dengue Hemorrhagic Fever

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8Disease Ontology
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Symptoms:

8
  • reduction in the fluid part of the blood
  • hemorrhagic lesions of the skin
  • thrombocytopenia
  • high fever

Drugs & Therapeutics for Dengue Hemorrhagic Fever

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Dengue Hemorrhagic Fever

Search NIH Clinical Center for Dengue Hemorrhagic Fever

Genetic Tests for Dengue Hemorrhagic Fever

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Anatomical Context for Dengue Hemorrhagic Fever

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33MalaCards
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MalaCards organs/tissues related to Dengue Hemorrhagic Fever:

33
Skin, Endothelial, T cells, Pituitary, Liver, Monocytes, Pancreas, Testes, Kidney, Bone marrow, Whole blood, Bone, B cells

Animal Models for Dengue Hemorrhagic Fever or affiliated genes

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Publications for Dengue Hemorrhagic Fever

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52PubMed
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Articles related to Dengue Hemorrhagic Fever:

(show top 50)    (show all 436)
idTitleAuthorsYear
1
Hemostatic derangement in dengue hemorrhagic fever. (24120237)
2014
2
Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome. (24305068)
2013
3
Acute pancreatitis in dengue hemorrhagic fever. (22451187)
2012
4
Use of pentoxifylline in treatment of children with dengue hemorrhagic fever. (22481426)
2012
5
Persistent thrombocytopenia in dengue hemorrhagic fever. (21992910)
2011
6
Splenic rupture in dengue hemorrhagic fever: report of a case and review. (21788711)
2011
7
Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005. (20205587)
2010
8
Clinical characteristics, risk factors, and outcomes in adults experiencing dengue hemorrhagic fever complicated with acute renal failure. (19346394)
2009
9
Dengue hemorrhagic fever complicated with encephalopathy and myocarditis: a case report. (19245163)
2008
10
Dengue and dengue hemorrhagic fever: management issues in an intensive care unit. (17530136)
2007
11
Difficulty in diagnosis and treatment of dengue hemorrhagic fever in patients with chronic renal failure: report of three cases of mortality. (17426183)
2007
12
T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal? (16517753)
2006
13
Slower rates of clearance of viral load and virus-containing immune complexes in patients with dengue hemorrhagic fever. (16983615)
2006
14
Clinical features, complications and atypical manifestations of children with severe forms of dengue hemorrhagic fever in South India. (17090900)
2006
15
Economic impact of dengue fever/dengue hemorrhagic fever in Thailand at the family and population levels. (15964964)
2005
16
The emergence of epidemic dengue fever and dengue hemorrhagic fever in the Americas: a case of failed public health policy. (15969972)
2005
17
Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever. (15827272)
2005
18
The correlation between coagulation test and albumin with antithrombin III in Dengue hemorrhagic fever. (15931699)
2004
19
Serious thrombocytopenia due to dengue hemorrhagic fever treated with high dosages of immunoglobulin. (12802766)
2003
20
Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges. (12727523)
2003
21
Coagulation abnormalities in dengue hemorrhagic Fever: serial investigations in 167 Vietnamese children with Dengue shock syndrome. (12115093)
2002
22
Epidemiology of dengue in Sri Lanka before and after the emergence of epidemic dengue hemorrhagic fever. (12224589)
2002
23
The dengue and dengue hemorrhagic fever epidemic in Puerto Rico, 1994-1995. (11425166)
2001
24
The risk of dengue hemorrhagic fever (DHF) outbreak based on vector density in Kurau, Riau province, Indonesia. (11414442)
2000
25
A comparison of the pattern of liver involvement in dengue hemorrhagic fever with classic dengue fever. (11127322)
2000
26
Determining the incidence of dengue hemorrhagic fever in Puerto Rico. (10730299)
1999
27
A clinical study of the patients with dengue hemorrhagic fever during the epidemic of 1996 at Lucknow, India. (10928368)
1999
28
Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. (10515800)
1999
29
The 1996 outbreak of dengue hemorrhagic fever in Delhi, India. (10437946)
1998
30
Gallbladder wall thickening in dengue hemorrhagic fever: an ultrasonographic study. (7673451)
1995
31
Dengue virus and endothelial cell: a related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever. (7886587)
1993
32
Emergence of epidemic dengue/dengue hemorrhagic fever as a public health problem in the Americas. (8012739)
1993
33
The first epidemic of dengue hemorrhagic fever in the People's Republic of China. (2042704)
1991
34
Dengue hemorrhagic fever in Cuba, 1981: a retrospective seroepidemiologic study. (2316788)
1990
35
International symposium on dengue and dengue hemorrhagic fever. Introduction. (1983048)
1990
36
Global epidemiology of dengue hemorrhagic fever. (2098928)
1990
37
Association of dengue hemorrhagic fever with the HLA system. (3498669)
1987
38
Dengue hemorrhagic fever--Puerto Rico. (3097497)
1986
39
Antibody-capture ELISA for detection of immunoglobulin M antibodies in sera from Japanese encephalitis and dengue hemorrhagic fever patients. (2989309)
1985
40
Atypical lymphocyte in dengue hemorrhagic fever: its value in diagnosis. (6740378)
1984
41
Surveillance of dengue hemorrhagic fever cases in Thailand. (7342320)
1981
42
Dengue hemorrhagic fever in Malaysia: the 1973 epidemic. (6105712)
1980
43
Early recognition of severe dengue hemorrhagic fever. (632709)
1978
44
Glomerular changes in dengue hemorrhagic fever. (786215)
1976
45
Immunofluorescent staining of the surfaces of lymphocytes in suspension from patients with dengue hemorrhagic fever. (61729)
1976
46
Dengue hemorrhagic fever: hospital reporting taken as an index of health education effectiveness. (140560)
1976
47
Indirect fluorescent antibody technic for demonstration of serum antibody in dengue hemorrhagic fever cases. (1099896)
1975
48
Detection of sporadic cases of dengue hemorrhagic fever. (5501443)
1970
49
Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. (5419206)
1970
50
Observations related to pathogenesis of dengue hemorrhagic fever. V. Examination of agspecific sequential infection rates using a mathematical model. (5419207)
1970

Variations for Dengue Hemorrhagic Fever

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Expression for genes affiliated with Dengue Hemorrhagic Fever

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dengue Hemorrhagic Fever

Search GEO for disease gene expression data for Dengue Hemorrhagic Fever.

Pathways for genes affiliated with Dengue Hemorrhagic Fever

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 53QIAGEN, 60Thomson Reuters, 54R&D Systems
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Pathways related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL2 signaling events mediated by STAT538
9.9PTPN11, LTA
29.9CD40LG, LTA
39.2IFNA10, IFNA16, IFNA17
4
Show member pathways
8.9PTPN11, IFNA10, IFNA17, IFNA16
5
Show member pathways
8.9PTPN11, IFNA10, IFNA17, IFNA16
68.4IFNA17, IFNA16, IFNA10, IFNA13
78.4IFNA16, IFNA17, IFNA10, IFNA13
8
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.4IFNA16, IFNA17, IFNA13, IFNA10
98.4IFNA13, IFNA17, IFNA16, IFNA10
10
Show member pathways
8.4IFNA17, IFNA16, IFNA13, IFNA10
118.4IFNA10, IFNA13, IFNA16, IFNA17
128.1IFNA16, IFNA17, IFNA13, LTA, IFNA10
13
Show member pathways
8.1IFNA10, LTA, IFNA17, IFNA16, IFNA13
14
Show member pathways
8.1IFNA16, IFNA10, IFNA13, PTPN11, IFNA17
15
Show member pathways
Immune response CD16 signaling in NK cells60
8.1PTPN11, IFNA16, IFNA17, IFNA13, IFNA10
16
Show member pathways
7.8CD40LG, IFNA10, IFNA13, LTA, IFNA16, IFNA17
177.8IFNA13, IFNW1, IFNA10, IFNA17, IFNA16
18
Show member pathways
7.4IFNA17, IFNA16, LTA, IFNA13, IVNS1ABP, IFNA10
197.3IFNW1, IFNK, IFNA16, IFNA13, IFNA17, IFNA10
20
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
7.0PTPN11, IFNA17, IFNK, IFNA10, IFNA13, IFNA16
21
Show member pathways
6.8IFNW1, IFNE, IFNA10, IFNA17, IFNA16, IFNA13
22
Show member pathways
Type III interferon signaling38
6.5PTPN11, IFNK, IFNA16, IFNA17, IFNA10, IFNE
23
Show member pathways
6.2CD40LG, IFNK, IFNA16, IFNA17, IFNA10, IFNE

Compounds for genes affiliated with Dengue Hemorrhagic Fever

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45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1okt3459.9CD40LG, LTA
2neopterin459.9LTA, CD40LG
3mycophenolate mofetil45 51 1111.8LTA, CD40LG
4herbimycin a45 6110.7LTA, CD40LG, PTPN11
5rantes459.7LTA, CD40LG, PTPN11
6acetylcholine45 51 29 24 1113.6PTPN11, CD40LG, LTA
7ivig459.6LTA, CD40LG

GO Terms for genes affiliated with Dengue Hemorrhagic Fever

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16Gene Ontology
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Cellular components related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9IFNA13, IFNA10, IFNA17, IFNA16, IFNK
2extracellular spaceGO:0056155.9IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16

Biological processes related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1response to virusGO:0096158.3IVNS1ABP, IFNK, IFNA17, IFNW1
2regulation of type I interferon-mediated signaling pathwayGO:0603388.2IFNA13, IFNA10, PTPN11, IFNA17, IFNA16
3blood coagulationGO:0075968.1PTPN11, IFNA10, IFNA17, IFNA16, IFNA13
4type I interferon signaling pathwayGO:0603378.0IFNA16, PTPN11, IFNA13, IFNA10, IFNA17
5regulation of MHC class I biosynthetic processGO:0453437.1IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
6positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:0331417.1IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
7response to exogenous dsRNAGO:0433307.1IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
8natural killer cell activation involved in immune responseGO:0023237.0IFNK, IFNA13, IFNW1, IFNE, IFNA10, IFNA17
9T cell activation involved in immune responseGO:0022867.0IFNA13, IFNW1, IFNA10, IFNK, IFNA16, IFNA17
10adaptive immune responseGO:0022507.0IFNK, IFNA16, IFNA17, IFNA10, IFNE, IFNW1
11defense response to virusGO:0516076.9IFNK, IFNA16, IFNA17, IFNE, IFNW1, IFNA13
12B cell proliferationGO:0421006.8CD40LG, IFNK, IFNA16, IFNA17, IFNA13, IFNE
13humoral immune responseGO:0069596.8IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
14B cell differentiationGO:0301836.8IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
15cytokine-mediated signaling pathwayGO:0192216.7PTPN11, IFNA10, IFNA17, IFNA13, IFNW1, IFNE
16innate immune responseGO:0450876.5IFNE, PTPN11, IFNA16, IFNW1, IFNA13, IFNA10

Molecular functions related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.9LTA, CD40LG
2type I interferon receptor bindingGO:0051326.5IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
3cytokine activityGO:0051256.1LTA, IFNA13, IFNW1, IFNE, IFNA10, IFNA17

Products for genes affiliated with Dengue Hemorrhagic Fever

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  • Antibodies
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Sources for Dengue Hemorrhagic Fever

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet