DHF
MCID: DNG002
MIFTS: 63

Dengue Hemorrhagic Fever (DHF) malady

Categories: Infectious diseases

Aliases & Classifications for Dengue Hemorrhagic Fever

Aliases & Descriptions for Dengue Hemorrhagic Fever:

Name: Dengue Hemorrhagic Fever 38 12 52 3 14
Severe Dengue 42 69
Dhf 12 3
Dengue Haemorrhagic Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12206
ICD10 33 A91
MeSH 42 D019595
NCIt 47 C34683
UMLS 69 C0019100

Summaries for Dengue Hemorrhagic Fever

CDC : 3 With more than one-third of the world’s population living in areas at risk for infection, dengue virus is a leading cause of illness and death in the tropics and subtropics. As many as 400 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are not yet any vaccines to prevent infection with dengue virus and the most effective protective measures are those that avoid mosquito bites. When infected, early recognition and prompt supportive treatment can substantially lower the risk of medical complications and death.

MalaCards based summary : Dengue Hemorrhagic Fever, also known as severe dengue, is related to dengue disease and hepatitis, and has symptoms including hemorrhagic lesions of the skin, thrombocytopenia and reduction in the fluid part of the blood. An important gene associated with Dengue Hemorrhagic Fever is CD209 (CD209 Molecule), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Histamine and Ketotifen have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and kidney, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Disease Ontology : 12 A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has symptom hemorrhagic lesions of the skin, has symptom thrombocytopenia, has symptom reduction in the fluid part of the blood, and has symptom high fever.

Related Diseases for Dengue Hemorrhagic Fever

Diseases related to Dengue Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 346)
id Related Disease Score Top Affiliating Genes
1 dengue disease 32.6 IFNG IL10 IL6 TNF
2 hepatitis 30.0 HLA-A HLA-DRB1 IFNG IL10 IL6 TNF
3 neuropathy 29.7 CXCL8 IL6 TNF
4 hemorrhagic fever 11.1
5 dengue fever, protection against 11.0
6 dengue shock syndrome 10.4
7 pyridoxal 5'-phosphate-dependent epilepsy 10.4 IL10 TNF
8 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 TNF
9 congenital dyserythropoietic anemia 10.3 ALB TNF
10 nondystrophic myotonia 10.3 ALB F2
11 parovarian cyst 10.3 CD209 F2 TNF
12 sacral nerve root cysts 10.3 HLA-A HLA-DRB1
13 thrombocytopenia 10.3
14 nystagmus, congenital motor, autosomal recessive 10.3 HLA-A HLA-DRB1 TNF
15 aseptic meningitis 10.3 HLA-A HLA-DRB1 TNF
16 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.3 IFNG IL10 TNF
17 osteodysplasty precocious of danks mayne and kozlowski 10.2 IFNG IL10 TNF
18 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
19 infiltrating ureter transitional cell carcinoma 10.2 ALB F2 TNF
20 prostatic hypertrophy 10.2 F2 F3 HLA-A
21 distal trisomy 14q 10.2 HLA-DRB1 IFNG TNF
22 myofibroma 10.2 HLA-DRB1 IFNG IL10
23 patau syndrome 10.2 HLA-A HLA-DRB1 TNF
24 acute myeloid leukemia with recurrent genetic anomaly 10.2 IFNG IL10 TNF
25 microcephaly 10.2 IFNG IL10 TNF
26 uterine corpus cancer 10.2 F2 F3 TNF
27 abnormal retinal correspondence 10.2 IFNG IL10 TNF
28 maturity-onset diabetes of the young 10.2 CD40LG IL10
29 transient tic disorder 10.2 IL10 IL6 TNF
30 cerebral sarcoidosis 10.2 ALB HLA-A HLA-DRB1
31 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 IL10 IL6 TNF
32 endotheliitis 10.2
33 phlyctenulosis 10.2 IL10 IL6 TNF
34 ciliary discoordination, due to random ciliary orientation 10.2 ALB IFNG IL10
35 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 10.2 ALB F2 F3
36 acanthoma 10.2 HLA-A HLA-DRB1 IFNG
37 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.2 IL10 IL6 TNF
38 swine influenza 10.2 HLA-DRB1 IL6 TNF
39 rosacea 10.2 ALB IFNG IL10
40 primary ciliary dyskinesia 10.2 IL10 IL6 TNF
41 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 HLA-DRB1 IL6 TNF
42 bladder signet ring cell adenocarcinoma 10.2 IL10 IL6 TNF
43 bickerstaff brainstem encephalitis 10.2 HLA-A HLA-DRB1 IFNG
44 hemarthrosis 10.2 F2 F3
45 capillary hemangioma 10.2 ALB F2 F3
46 bile duct adenocarcinoma 10.2 ALB CD40LG
47 hypertropia 10.2 ALB IFNG TNF
48 ovarian papillary cystadenoma 10.2 ALB F2 IFNG
49 alcoholic gastritis 10.2 ALB F2 F3
50 inflammatory bowel disease 2 10.2 CD209 IFNG IL10

Graphical network of the top 20 diseases related to Dengue Hemorrhagic Fever:



Diseases related to Dengue Hemorrhagic Fever

Symptoms & Phenotypes for Dengue Hemorrhagic Fever

Symptoms:

12
  • hemorrhagic lesions of the skin
  • thrombocytopenia
  • reduction in the fluid part of the blood
  • high fever

GenomeRNAi Phenotypes related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CD40LG CXCL8 F2 IL10 STAT1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CD40LG CXCL8 F2 IL10 STAT1 TNF

MGI Mouse Phenotypes related to Dengue Hemorrhagic Fever:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.17 CD40LG F2 F3 FCGR2A IFNG IL10
2 cardiovascular system MP:0005385 10.15 CD40LG F2 F3 IFNG IL10 IL6
3 immune system MP:0005387 10.14 TLR3 TNF CD40LG F2 F3 FCGR2A
4 mortality/aging MP:0010768 10.1 ALB CD40LG F2 F3 FCGR2A IFNG
5 endocrine/exocrine gland MP:0005379 10.06 IL6 STAT1 TLR3 TNF ALB CD40LG
6 digestive/alimentary MP:0005381 10.02 ALB F2 IFNG IL10 IL6 STAT1
7 integument MP:0010771 9.97 CD40LG F2 F3 IFNG IL10 IL6
8 muscle MP:0005369 9.86 ALB F3 IFNG IL10 IL6 STAT1
9 neoplasm MP:0002006 9.76 ALB F3 IFNG IL10 IL6 STAT1
10 respiratory system MP:0005388 9.5 F2 F3 IFNG IL10 IL6 TLR3
11 skeleton MP:0005390 9.23 CD40LG F2 FCGR2A IFNG IL10 IL6

Drugs & Therapeutics for Dengue Hemorrhagic Fever

Drugs for Dengue Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
2
Ketotifen Approved Phase 4 34580-14-8, 34580-13-7 3827
3 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
4
Histamine Phosphate Phase 4 51-74-1 65513
5 Neurotransmitter Agents Phase 4
6 Histamine Antagonists Phase 4
7 Histamine H1 Antagonists Phase 4
8 Dermatologic Agents Phase 4
9 Anti-Allergic Agents Phase 4
10 Antipruritics Phase 4
11
Ivermectin Approved, Vet_approved Phase 2, Phase 3 70288-86-7 6474909 46936176
12 DEET Phase 3
13 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
14 Anti-Infective Agents Phase 2, Phase 3,Phase 1
15 Protective Agents Phase 3
16 Insect Repellents Phase 3
17 Antiparasitic Agents Phase 2, Phase 3,Phase 1
18 Heptavalent Pneumococcal Conjugate Vaccine Phase 3,Phase 2
19
chloroquine Approved, Vet_approved Phase 1, Phase 2 54-05-7 2719
20
Ribavirin Approved Phase 2 36791-04-5 37542
21
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
22
Neomycin Approved, Vet_approved Phase 1, Phase 2 1404-04-2 8378
23 Chloroquine diphosphate Phase 1, Phase 2 50-63-5
24 Analgesics Phase 1, Phase 2
25 Cortisol succinate Phase 2
26 Analgesics, Non-Narcotic Phase 1, Phase 2
27 Peripheral Nervous System Agents Phase 1, Phase 2
28 Hydrocortisone 17-butyrate 21-propionate Phase 2
29 Hydrocortisone acetate Phase 2
30 Anthelmintics Phase 1, Phase 2
31 Anti-Inflammatory Agents Phase 1, Phase 2
32 Antimalarials Phase 1, Phase 2
33 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
34 Antimetabolites Phase 2
35 Antirheumatic Agents Phase 1, Phase 2
36 Antiviral Agents Phase 2
37 Antiprotozoal Agents Phase 1, Phase 2
38 Coagulants Phase 2
39 Hemostatics Phase 2
40 Immunoglobulins Phase 1, Phase 2
41 Antibodies Phase 1, Phase 2
42
Aluminum hydroxide Approved Phase 1 21645-51-2
43 Adjuvants, Immunologic Phase 1
44 Gastrointestinal Agents Phase 1
45 Aluminum sulfate Phase 1
46 Antacids Phase 1
47 Anti-Ulcer Agents Phase 1
48
Acetaminophen Approved 103-90-2 1983
49
Ibuprofen Approved 15687-27-1 3672
50
Artesunate Approved 88495-63-0 6917864 5464098

Interventional clinical trials:

(show top 50) (show all 141)
id Name Status NCT ID Phase
1 Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Recruiting NCT02673840 Phase 4
2 Immunity Period After One Dose of Yellow Fever Vaccine in Adults and Children (Paraiba Study) Recruiting NCT02555072 Phase 4
3 Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS) Unknown status NCT00966628 Phase 3
4 Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR Unknown status NCT00938379 Phase 3
5 Study of a Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 11 Years in Malaysia Completed NCT01254422 Phase 3
6 Study of a Booster Injection of Pentaxim™ Vaccine Administered With Dengue Vaccine in Healthy Toddlers Completed NCT01411241 Phase 3
7 Study of a Tetravalent Dengue Vaccine in Healthy Adults in Australia Completed NCT01134263 Phase 3
8 Study of Yellow Fever Vaccine Administered With Tetravalent Dengue Vaccine in Healthy Toddlers Completed NCT01436396 Phase 3
9 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Cervarix® Recruiting NCT02979535 Phase 3
10 Efficacy and Safety of Ivermectin Against Dengue Infection Recruiting NCT02045069 Phase 2, Phase 3
11 Phase III Trial to Evaluate Efficacy and Safety of a Tetravalent Dengue Vaccine Recruiting NCT02406729 Phase 3
12 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia Active, not recruiting NCT01373281 Phase 3
13 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America Active, not recruiting NCT01374516 Phase 3
14 Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children Active, not recruiting NCT02747927 Phase 3
15 Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects Not yet recruiting NCT02992418 Phase 3
16 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Gardasil® Not yet recruiting NCT02993757 Phase 3
17 Chinese and Western Medicine Treatment of Fever Associated With Bleeding Symptoms Unknown status NCT01973855 Phase 2
18 The Effect of Chloroquine in the Treatment of Patients With Dengue Unknown status NCT00849602 Phase 1, Phase 2
19 Activated Recombinant Human Factor VII in Patients With Dengue Haemorrhagic Fever Completed NCT01601613 Phase 2
20 Study of CYD Dengue Vaccine in Healthy Children and Adolescents in South America Completed NCT01187433 Phase 2
21 A Study of Dengue Vaccine in Healthy Toddlers Aged 12 to 15 Months in the Philippines Completed NCT01064141 Phase 2
22 Immunogenicity and Safety of Three Formulations of Dengue Vaccines in Healthy Adults Aged 18 to 45 Years in the US Completed NCT00617344 Phase 2
23 Study of a Tetravalent Dengue Vaccine in Healthy Adult Subjects Aged 18 to 45 Years in India Completed NCT01550289 Phase 2
24 Study of ChimeriVax™ Dengue Tetravalent Vaccine in Adult Subjects Completed NCT00730288 Phase 2
25 Safety and Immunogenicity of Formulations of Dengue Vaccines in Healthy Flavivirus-Naïve Adults Completed NCT00740155 Phase 2
26 Immunogenicity and Safety of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Children and Adolescents in Latin America Completed NCT00993447 Phase 2
27 Study of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Subjects in Singapore Completed NCT00880893 Phase 2
28 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
29 Efficacy and Safety of Dengue Vaccine in Healthy Children Completed NCT00842530 Phase 2
30 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Peruvian Children Aged 2 to 11 Years Completed NCT00788151 Phase 2
31 Immunologic Mechanisms of Immune Interference and/or Cross-Neutralizing Immunity After CYD Tetravalent Dengue Vaccine Completed NCT01943825 Phase 2
32 Immune Response to Different Schedules of a Tetravalent Dengue Vaccine Given With or Without Yellow Fever Vaccine Completed NCT01488890 Phase 2
33 A Study of Two Doses of WRAIR Dengue Vaccine Administered Six Months Apart to Healthy Adults and Children Completed NCT00468858 Phase 2
34 A Phase I/II Trial of Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naive Infants Completed NCT00322049 Phase 1, Phase 2
35 A Trial of a Walter Reed Army Institute of Research (WRAIR) Live Attenuated Virus Tetravalent Dengue Vaccine in Healthy US Adults Completed NCT00239577 Phase 2
36 A Phase II Trial of a WRAIR Live Attenuated Virus Tetravalent Dengue Vaccine in Healthy US Adults Completed NCT00350337 Phase 2
37 A Phase II Trial of a Live Attenuated Virus Tetravalent Dengue Vaccine in Healthy Adults in Thailand Completed NCT00370682 Phase 2
38 A Phase I/II Trial of a Tetravalent Live Attenuated DEN Vaccine in Flavivirus Antibody Naive Children Completed NCT01843621 Phase 1, Phase 2
39 Celgosivir as a Treatment Against Dengue Completed NCT01619969 Phase 1, Phase 2
40 Prospective Surveillance of Febrile Illness for Dengue-Endemic Areas in Asia Completed NCT01218906 Phase 2
41 Study of Febrile Illness for Dengue-Endemic Areas in Latin America Completed NCT01293331 Phase 1, Phase 2
42 A Phase I/II Trial of a Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naïve Children Completed NCT00384670 Phase 1, Phase 2
43 Safety and Immunogenicity of Three Formulations of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) Completed NCT02193087 Phase 2
44 Study to Investigate the Safety and Immunogenicity of a Tetravalent Chimeric Dengue Vaccine in Healthy Volunteers Between the Ages of 1.5 - 45 Years Completed NCT01511250 Phase 2
45 The Role of Pre-existing Cross-reactive Antibodies in Determining the Efficacy of Vaccination in Humans Completed NCT01943305 Phase 2
46 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Booster Injection in Subjects Who Previously Completed a 3-dose Schedule Recruiting NCT02824198 Phase 2
47 Study of Varying Injection Schedules of TDENV-PIV Vaccine With AS03B Adjuvant and Placebo in Healthy US Adults Recruiting NCT02421367 Phase 1, Phase 2
48 A Zika Virus DNA Vaccine in Healthy Adults and Adolescents Recruiting NCT03110770 Phase 2
49 Evaluating the Safety of and Immune Response to a Dengue Vaccine (TV003) in Healthy Adults, Adolescents, and Children in Thailand Recruiting NCT02332733 Phase 2
50 Immunogenicity and Safety of 3-Dose and Booster Dose of Tetravalent Dengue Vaccine in Healthy Subjects 9 to 50 Years of Age Active, not recruiting NCT02628444 Phase 2

Search NIH Clinical Center for Dengue Hemorrhagic Fever

Cochrane evidence based reviews: severe dengue

Genetic Tests for Dengue Hemorrhagic Fever

Anatomical Context for Dengue Hemorrhagic Fever

MalaCards organs/tissues related to Dengue Hemorrhagic Fever:

39
Skin, Endothelial, Kidney, Monocytes, Thyroid, T Cells, Pituitary

Publications for Dengue Hemorrhagic Fever

Articles related to Dengue Hemorrhagic Fever:

(show top 50) (show all 493)
id Title Authors Year
1
Characterization of dengue virus infections in a sample of patients suggests unique clinical, immunological, and virological profiles that impact on the diagnosis of dengue and dengue hemorrhagic fever. ( 26990973 )
2016
2
Characteristics and Risk Factors for Fatality in Patients with Dengue Hemorrhagic Fever, Taiwan, 2014. ( 27273649 )
2016
3
50 Years Ago in TheJournal ofPediatrics: Shock Associated with Dengue Infection: I. Clinical and Physiological Manifestations of Dengue Hemorrhagic Fever in Thailand, 1964. ( 26922761 )
2016
4
Interleukin-10 as a Marker of Disease Progression in Dengue Hemorrhagic Fever. ( 26975948 )
2016
5
Immature Platelet Fraction, A Simple and Useful Novel Marker in Dengue Hemorrhagic Fever. ( 26897161 )
2016
6
Effectiveness of Recombinant Activated Factor VII (rFVII a) for Controlling Intractable Postpartum Bleeding in a case of Dengue Hemorrhagic Fever. ( 27298530 )
2016
7
Life-Threatening Thrombo-embolic Events in a Case of Dengue Hemorrhagic Fever. ( 27762119 )
2016
8
Dengue hemorrhagic fever and the kidney. ( 26699788 )
2016
9
Progress towards understanding the pathogenesis of dengue hemorrhagic fever. ( 27853992 )
2016
10
Human kidney damage in fatal dengue hemorrhagic fever results of glomeruli injury mainly induced by IL17. ( 26741825 )
2016
11
Caveolae-mediated albumin transcytosis is enhanced in dengue-infected human endothelial cells: A model of vascular leakage in dengue hemorrhagic fever. ( 27546060 )
2016
12
Association of BAK1 single nucleotide polymorphism with a risk for dengue hemorrhagic fever. ( 27401010 )
2016
13
Dengue Hemorrhagic Fever in a Child With Early-Onset Fistulizing Crohn Disease Under Infliximab and Azathioprine Treatment. ( 26709910 )
2016
14
Acute pancreatitis complicating dengue hemorrhagic fever. ( 27812667 )
2016
15
Management of severe dengue hemorrhagic fever and bleeding complications in a primigravidaA patient: a case report. ( 27998318 )
2016
16
A favorable outcome from dengue hemorrhagic fever: Teaching Hospital Kandy, Sri Lanka, May 2016. ( 27652805 )
2016
17
Complete Heart Block in Association with Dengue Hemorrhagic Fever. ( 27826348 )
2016
18
Dengue Hemorrhagic Fever Complicated by Intercostal Artery Hemorrhage. ( 26522190 )
2015
19
DENGUE FEVER AND DENGUE HEMORRHAGIC FEVER IN ADULTS. ( 26506734 )
2015
20
Morbidity Rate Prediction of Dengue Hemorrhagic Fever (DHF) Using the Support Vector Machine and the Aedes aegypti Infection Rate in Similar Climates and Geographical Areas. ( 25961289 )
2015
21
Association Between Increased Vascular Nitric Oxide Bioavailability and Progression to Dengue Hemorrhagic Fever in Adults. ( 25732810 )
2015
22
Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment. ( 26085471 )
2015
23
Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever. ( 26175069 )
2015
24
Hemophagocytic lymphohistiocytosis following dengue hemorrhagic fever in Hb H/Hb Constant Spring patient. ( 26011764 )
2015
25
Association of combinations of interleukin-10 and pro-inflammatory cytokine gene polymorphisms with dengue hemorrhagic fever. ( 25890879 )
2015
26
The Pattern of Adipose Tissue Accumulation during Early Infancy Provides an Environment for the Development of Dengue Hemorrhagic Fever. ( 26636570 )
2015
27
Frosted Branch Angiitis in a Patient Coinfected With Dengue Hemorrhagic Fever and Malaria. ( 26067694 )
2015
28
Arterial hypertension and skin allergy are risk factors for progression from dengue to dengue hemorrhagic fever: a case control study. ( 25996882 )
2015
29
Vascular leakage in dengue hemorrhagic Fever is associated with dengue infected monocytes, monocyte activation/exhaustion, and cytokines production. ( 25722892 )
2015
30
Dengue Hemorrhagic Fever in a Japanese Traveler with Pre-existing Japanese Encephalitis Virus Antibody. ( 26060418 )
2015
31
Hemophagocytic Lymphohistiocytosis Syndrome in Dengue Hemorrhagic Fever: Authors' Reply. ( 25589193 )
2015
32
Dengue hemorrhagic fever with discolored leg syndrome in a neonate: authors' reply. ( 25416092 )
2015
33
Dengue hemorrhagic fever with discolored leg syndrome in a neonate: correspondence. ( 25416091 )
2015
34
Hemophagocytic Lymphohistiocytosis Syndrome in Dengue Hemorrhagic Fever: Correspondence. ( 25589194 )
2015
35
FATAL RHABDOMYOLYSIS IN DENGUE HEMORRHAGIC FEVER: A CASE REPORT. ( 26506741 )
2015
36
Clinico-laboratory spectrum of dengue viral infection and risk factors associated with dengue hemorrhagic fever: a retrospective study. ( 26423145 )
2015
37
Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines. ( 25797204 )
2015
38
Comments on the clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile. ( 24790531 )
2014
39
Endothelial cells in dengue hemorrhagic fever. ( 25025934 )
2014
40
Pathologic highlights of dengue hemorrhagic fever in 13 autopsy cases from Myanmar. ( 24767772 )
2014
41
Successful use of N-acetyl cysteine and activated recombinant factor VII in fulminant hepatic failure and massive bleeding secondary to dengue hemorrhagic fever. ( 25400395 )
2014
42
The effect of a unique propolis compound (Propoelixa8c) on clinical outcomes in patients with dengue hemorrhagic fever. ( 25525372 )
2014
43
Hemostatic derangement in dengue hemorrhagic fever. ( 24120237 )
2014
44
Discovery and Characterization of Potential Prognostic Biomarkers for Dengue Hemorrhagic Fever. ( 25349378 )
2014
45
Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model. ( 24533162 )
2014
46
Dengue hemorrhagic fever: a rare cause of pituitary apoplexy. ( 24608476 )
2014
47
Elevated dengue virus nonstructural protein 1 serum levels and altered toll-like receptor 4 expression, nitric oxide, and tumor necrosis factor alpha production in dengue hemorrhagic Fever patients. ( 25580138 )
2014
48
Association DENV1 and DENV2 infection with high serum levels of soluble thrombomodulin and VEGF in patients with dengue fever and dengue hemorrhagic fever. ( 24600491 )
2014
49
Dengue hemorrhagic fever: Comparison of patients with primary and secondary infections. ( 24999118 )
2014
50
Clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile. ( 24790536 )
2014

Variations for Dengue Hemorrhagic Fever

Expression for Dengue Hemorrhagic Fever

LifeMap Discovery
Genes differentially expressed in tissues of Dengue Hemorrhagic Fever patients vs. healthy controls: 35 (show top 50) (show all 120)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CD38 CD38 molecule Blood + 4.80 0.000
2 IFI27 interferon, alpha-inducible protein 27 Blood + 4.71 0.000
3 RRM2 ribonucleotide reductase M2 Blood + 4.63 0.000
4 IGHM immunoglobulin heavy constant mu Blood + 4.61 0.000
5 BIRC5 baculoviral IAP repeat containing 5 Blood + 4.47 0.000
6 CAV1 caveolin 1, caveolae protein, 22kDa Blood + 4.41 0.000
7 DLGAP5 discs, large (Drosophila) homolog-associated protein 5 Blood + 4.31 0.000
8 XIST X inactive specific transcript (non-protein coding) Blood - 4.31 0.023
9 CEP55 centrosomal protein 55kDa Blood + 4.28 0.000
10 BUB1 BUB1 mitotic checkpoint serine/threonine kinase Blood + 4.21 0.000
11 SHCBP1 SHC SH2-domain binding protein 1 Blood + 4.13 0.000
12 PBK PDZ binding kinase Blood + 4.13 0.000
13 IGKV3-20 immunoglobulin kappa variable 3-20 Blood + 4.13 0.000
14 TYMS thymidylate synthetase Blood + 4.07 0.000
15 CDCA2 cell division cycle associated 2 Blood + 4.06 0.000
16 MKI67 marker of proliferation Ki-67 Blood + 4.00 0.000
17 CYAT1 immunoglobulin lambda light chain-like Blood + 3.98 0.000
18 MCM10 minichromosome maintenance 10 replication initiation factor Blood + 3.98 0.000
19 NOV nephroblastoma overexpressed Blood - 3.97 0.000
20 ZWINT ZW10 interacting kinetochore protein Blood + 3.96 0.000
21 CDK1 cyclin-dependent kinase 1 Blood + 3.92 0.000
22 HMMR hyaluronan-mediated motility receptor (RHAMM) Blood + 3.90 0.000
23 SDC1 syndecan 1 Blood + 3.89 0.000
24 SPC25 SPC25, NDC80 kinetochore complex component Blood + 3.84 0.000
25 NCAPG non-SMC condensin I complex, subunit G Blood + 3.84 0.000
26 TK1 thymidine kinase 1, soluble Blood + 3.82 0.000
27 CDC20 cell division cycle 20 Blood + 3.80 0.000
28 TNFRSF17 tumor necrosis factor receptor superfamily, member 17 Blood + 3.80 0.000
29 DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) Blood + 3.80 0.000
30 TOP2A topoisomerase (DNA) II alpha Blood + 3.80 0.000
31 PI3 peptidase inhibitor 3, skin-derived Blood - 3.76 0.000
32 GLDC glycine dehydrogenase (decarboxylating) Blood + 3.75 0.000
33 IGLJ3 immunoglobulin lambda joining 3 Blood + 3.75 0.000
34 SESN3 sestrin 3 Blood - 3.75 0.000
35 KIF2C kinesin family member 2C Blood + 3.74 0.000
36 CDT1 chromatin licensing and DNA replication factor 1 Blood + 3.72 0.000
37 CDKN3 cyclin-dependent kinase inhibitor 3 Blood + 3.71 0.000
38 KIAA0101 KIAA0101 Blood + 3.71 0.000
39 EIF1AY eukaryotic translation initiation factor 1A, Y-linked Blood + 3.71 0.034
40 CNTNAP3 contactin associated protein-like 3 Blood - 3.70 0.000
41 CENPA centromere protein A Blood + 3.69 0.000
42 TTK TTK protein kinase Blood + 3.67 0.000
43 ASPM abnormal spindle microtubule assembly Blood + 3.66 0.000
44 KIF11 kinesin family member 11 Blood + 3.64 0.000
45 IGL immunoglobulin lambda locus Blood + 3.64 0.000
46 CCNB2 cyclin B2 Blood + 3.61 0.000
47 BUB1B BUB1 mitotic checkpoint serine/threonine kinase B Blood + 3.60 0.000
48 CDC6 cell division cycle 6 Blood + 3.60 0.000
49 SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 Blood + 3.60 0.000
50 DUSP5 dual specificity phosphatase 5 Blood + 3.60 0.000
Search GEO for disease gene expression data for Dengue Hemorrhagic Fever.

Pathways for Dengue Hemorrhagic Fever

Pathways related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CD209 CD40LG CXCL8 FCGR2A HLA-A HLA-DRB1
2
Show member pathways
13.57 CXCL8 F2 IFNG IL10 IL6 STAT1
3
Show member pathways
13.44 CD40LG CXCL8 IL10 IL6 STAT1 STAT2
4
Show member pathways
13.37 CD40LG CXCL8 HLA-A HLA-DRB1 IFNG IL10
5
Show member pathways
13.21 HLA-DRB1 IFNG STAT1 STAT2 TLR3 TNF
6
Show member pathways
13.04 CD209 CXCL8 F3 IL6 STAT1 STAT2
7
Show member pathways
12.95 CXCL8 IFNG IL10 IL6 STAT1 STAT2
8
Show member pathways
12.76 CD40LG CXCL8 HLA-A HLA-DRB1 IFNG IL10
9
Show member pathways
12.67 CD40LG HLA-DRB1 IFNG IL10 TNF
10
Show member pathways
12.67 HLA-DRB1 IFNG IL10 IL6 STAT1 TNF
11
Show member pathways
12.65 F2 IFNG IL10 IL6 STAT1 TNF
12
Show member pathways
12.58 HLA-A HLA-DRB1 IFNG STAT1 STAT2
13 12.53 CD40LG IFNG IL10 STAT1 STAT2 TLR3
14
Show member pathways
12.49 CD40LG IFNG IL10 IL6 TNF
15 12.45 HLA-A HLA-DRB1 IL6 TNF
16
Show member pathways
12.41 ALB F2 IFNG IL6 TNF
17
Show member pathways
12.37 CXCL8 IFNG IL6 TNF
18
Show member pathways
12.35 IFNG IL6 STAT1 STAT2
19
Show member pathways
12.35 CD209 CXCL8 HLA-A HLA-DRB1 IFNG IL6
20 12.34 HLA-A HLA-DRB1 IFNG IL10
21
Show member pathways
12.31 CXCL8 IFNG IL6 STAT1 TLR3 TNF
22
Show member pathways
12.3 CXCL8 IL6 TLR3 TNF
23
Show member pathways
12.29 IFNG IL10 IL6 STAT1 STAT2
24
Show member pathways
12.27 CXCL8 IFNG IL6 STAT1 TNF
25 12.26 IFNG IL6 STAT1 TLR3 TNF
26
Show member pathways
12.25 CD40LG FCGR2A HLA-DRB1 IFNG IL10 STAT1
27 12.22 CXCL8 IL10 IL6 TNF
28 12.19 CD209 FCGR2A HLA-A HLA-DRB1
29 12.14 CXCL8 STAT1 STAT2 TLR3 TNF
30 12.13 FCGR2A IFNG STAT1 STAT2 TNF
31 12.12 IL6 STAT1 STAT2 TNF
32 12.09 CXCL8 FCGR2A IFNG IL6 TNF
33 12.07 CXCL8 IL10 IL6 STAT1 TNF
34
Show member pathways
12.04 HLA-A HLA-DRB1 IFNG STAT1
35 12.01 CD209 FCGR2A HLA-DRB1 IFNG IL10 IL6
36 12 CD209 FCGR2A IFNG IL10 IL6 TNF
37
Show member pathways
11.99 IFNG IL6 STAT1 TLR3
38 11.98 CXCL8 F3 IL6 STAT1 TNF
39 11.96 CXCL8 IFNG IL10 IL6 TNF
40 11.93 CXCL8 HLA-DRB1 IFNG IL6 TNF
41 11.91 HLA-DRB1 IL6 TNF
42 11.9 CD40LG CXCL8 TNF
43 11.89 CXCL8 IFNG IL6 STAT1
44 11.85 CXCL8 IFNG IL6
45
Show member pathways
11.85 CD40LG CXCL8 IFNG TNF
46 11.85 CXCL8 IL10 IL6 TNF
47 11.83 CD209 IFNG IL10 IL6 TNF
48
Show member pathways
11.83 IFNG IL10 IL6 STAT1 STAT2 TLR3
49 11.82 IFNG IL10 TNF
50 11.79 HLA-DRB1 STAT1 STAT2

GO Terms for Dengue Hemorrhagic Fever

Cellular components related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 ALB CD209 CD40LG CXCL8 F2 F3
2 extracellular space GO:0005615 9.81 ALB CD40LG CXCL8 F2 F3 IFNG
3 cell surface GO:0009986 9.5 CD209 CD40LG F3 HLA-A HLA-DRB1 TLR3
4 external side of plasma membrane GO:0009897 9.17 CD209 CD40LG F2 HLA-DRB1 IFNG IL6

Biological processes related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 41)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.94 IFNG IL10 TLR3 TNF
2 positive regulation of protein phosphorylation GO:0001934 9.88 F2 IFNG TLR3 TNF
3 inflammatory response GO:0006954 9.85 CD40LG CXCL8 IL10 IL6 TLR3 TNF
4 positive regulation of protein kinase B signaling GO:0051897 9.84 F3 IL6 TNF
5 response to glucocorticoid GO:0051384 9.83 IL10 IL6 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 CD40LG IL6 TLR3 TNF
7 type I interferon signaling pathway GO:0060337 9.82 HLA-A STAT1 STAT2
8 positive regulation of T cell proliferation GO:0042102 9.81 CD40LG IFNG IL6
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 IL6 STAT1 TNF
10 humoral immune response GO:0006959 9.8 IFNG IL6 TNF
11 positive regulation of interleukin-6 production GO:0032755 9.77 IL6 TLR3 TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.75 IFNG IL6 TNF
13 extrinsic apoptotic signaling pathway GO:0097191 9.74 IFNG TLR3 TNF
14 defense response to virus GO:0051607 9.72 IFNG IL6 STAT1 STAT2 TLR3
15 interferon-gamma-mediated signaling pathway GO:0060333 9.71 HLA-A HLA-DRB1 IFNG STAT1
16 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 IL10
17 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.68 IFNG STAT1
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL10 TNF
19 positive regulation of protein import into nucleus, translocation GO:0033160 9.67 IFNG IL6
20 positive regulation of interleukin-12 production GO:0032735 9.67 CD40LG IFNG TLR3
21 negative regulation of lipid storage GO:0010888 9.66 IL6 TNF
22 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
23 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IFNG IL10
24 defense response to protozoan GO:0042832 9.65 IFNG IL10 IL6
25 positive regulation of chemokine production GO:0032722 9.63 IL6 TLR3 TNF
26 necroptotic signaling pathway GO:0097527 9.62 TLR3 TNF
27 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
28 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.61 IL6 TNF
29 negative regulation of growth of symbiont in host GO:0044130 9.61 IFNG IL10 TNF
30 regulation of immunoglobulin secretion GO:0051023 9.6 CD40LG TNF
31 receptor biosynthetic process GO:0032800 9.56 IL10 TNF
32 antigen processing and presentation GO:0019882 9.56 CD209 HLA-A HLA-DRB1 IFNG
33 neutrophil apoptotic process GO:0001781 9.55 IFNG IL6
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IFNG TNF
35 positive regulation of vitamin D biosynthetic process GO:0060557 9.51 IFNG TNF
36 cellular response to lipopolysaccharide GO:0071222 9.35 CXCL8 IFNG IL10 IL6 TNF
37 positive regulation of chemokine biosynthetic process GO:0045080 9.33 IFNG TLR3 TNF
38 immune response GO:0006955 9.23 CD40LG CXCL8 HLA-A HLA-DRB1 IFNG IL10
39 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.16 IFNG IL10 IL6 STAT1 TLR3 TNF
40 positive regulation of transcription, DNA-templated GO:0045893 10.08 IFNG IL10 IL6 STAT1 TNF
41 viral process GO:0016032 10 CD209 HLA-A HLA-DRB1 STAT1 STAT2

Molecular functions related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG STAT1 TNF
2 peptide antigen binding GO:0042605 9.13 CD209 HLA-A HLA-DRB1
3 cytokine activity GO:0005125 9.1 CD40LG CXCL8 IFNG IL10 IL6 TNF

Sources for Dengue Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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