MCID: DNG002
MIFTS: 50

Dengue Hemorrhagic Fever malady

Infectious diseases category

Summaries for Dengue Hemorrhagic Fever

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Disease Ontology:9 A dengue disease that occurs when a person experiences a second infection with a heterologous dengue virus serotype, which is transmitted by aedes mosquito bite. the infection has symptom hemorrhagic lesions of the skin, has symptom thrombocytopenia, has symptom reduction in the fluid part of the blood, and has symptom high fever.

MalaCards based summary: Dengue Hemorrhagic Fever, also known as dhf, is related to dengue disease and japanese encephalitis, and has symptoms including hemorrhagic lesions of the skin, thrombocytopenia and reduction in the fluid part of the blood. An important gene associated with Dengue Hemorrhagic Fever is LTA (lymphotoxin alpha), and among its related pathways are IL2 signaling events mediated by PI3K and IL4-mediated signaling events. The compounds okt3 and neopterin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and kidney.

Aliases & Classifications for Dengue Hemorrhagic Fever

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Dengue Hemorrhagic Fever, Aliases & Descriptions:

Name: Dengue Hemorrhagic Fever 30 9 43 3
Dhf 9 3
 
Severe Dengue 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology9 DOID:12206
MeSH33 D019595
NCIt38 C34683
ICD1025 A91

Related Diseases for Dengue Hemorrhagic Fever

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Graphical network of the top 20 diseases related to Dengue Hemorrhagic Fever:



Diseases related to dengue hemorrhagic fever

Symptoms for Dengue Hemorrhagic Fever

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Symptoms:

 9
  • hemorrhagic lesions of the skin
  • thrombocytopenia
  • reduction in the fluid part of the blood
  • high fever

Drugs & Therapeutics for Dengue Hemorrhagic Fever

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Drug clinical trials:

Search ClinicalTrials for Dengue Hemorrhagic Fever

Search NIH Clinical Center for Dengue Hemorrhagic Fever

Genetic Tests for Dengue Hemorrhagic Fever

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Anatomical Context for Dengue Hemorrhagic Fever

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MalaCards organs/tissues related to Dengue Hemorrhagic Fever:

31
Skin, T cells, Kidney, Pituitary, Liver, Endothelial, Bone, B cells, Retina, Thyroid, Testis, Myeloid, Monocytes, Pancreas, Testes, Bone marrow, Whole blood

Animal Models for Dengue Hemorrhagic Fever or affiliated genes

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Publications for Dengue Hemorrhagic Fever

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Articles related to Dengue Hemorrhagic Fever:

(show top 50)    (show all 461)
idTitleAuthorsYear
1
Association of combinations of interleukin-10 and pro-inflammatory cytokine gene polymorphisms with dengue hemorrhagic fever. (25890879)
2015
2
Hemostatic derangement in dengue hemorrhagic fever. (24120237)
2014
3
Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome. (24305068)
2013
4
Acute pancreatitis in dengue hemorrhagic fever. (22451187)
2012
5
Use of pentoxifylline in treatment of children with dengue hemorrhagic fever. (22481426)
2012
6
Persistent thrombocytopenia in dengue hemorrhagic fever. (21992910)
2011
7
Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005. (20205587)
2010
8
Clinical characteristics, risk factors, and outcomes in adults experiencing dengue hemorrhagic fever complicated with acute renal failure. (19346394)
2009
9
Dengue hemorrhagic fever complicated with encephalopathy and myocarditis: a case report. (19245163)
2008
10
Dengue and dengue hemorrhagic fever: management issues in an intensive care unit. (17530136)
2007
11
Difficulty in diagnosis and treatment of dengue hemorrhagic fever in patients with chronic renal failure: report of three cases of mortality. (17426183)
2007
12
T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal? (16517753)
2006
13
Slower rates of clearance of viral load and virus-containing immune complexes in patients with dengue hemorrhagic fever. (16983615)
2006
14
Clinical features, complications and atypical manifestations of children with severe forms of dengue hemorrhagic fever in South India. (17090900)
2006
15
Economic impact of dengue fever/dengue hemorrhagic fever in Thailand at the family and population levels. (15964964)
2005
16
The emergence of epidemic dengue fever and dengue hemorrhagic fever in the Americas: a case of failed public health policy. (15969972)
2005
17
Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever. (15827272)
2005
18
The correlation between coagulation test and albumin with antithrombin III in Dengue hemorrhagic fever. (15931699)
2004
19
Serious thrombocytopenia due to dengue hemorrhagic fever treated with high dosages of immunoglobulin. (12802766)
2003
20
Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges. (12727523)
2003
21
Coagulation abnormalities in dengue hemorrhagic Fever: serial investigations in 167 Vietnamese children with Dengue shock syndrome. (12115093)
2002
22
Epidemiology of dengue in Sri Lanka before and after the emergence of epidemic dengue hemorrhagic fever. (12224589)
2002
23
The dengue and dengue hemorrhagic fever epidemic in Puerto Rico, 1994-1995. (11425166)
2001
24
The risk of dengue hemorrhagic fever (DHF) outbreak based on vector density in Kurau, Riau province, Indonesia. (11414442)
2000
25
A comparison of the pattern of liver involvement in dengue hemorrhagic fever with classic dengue fever. (11127322)
2000
26
Determining the incidence of dengue hemorrhagic fever in Puerto Rico. (10730299)
1999
27
A clinical study of the patients with dengue hemorrhagic fever during the epidemic of 1996 at Lucknow, India. (10928368)
1999
28
Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. (10515800)
1999
29
The 1996 outbreak of dengue hemorrhagic fever in Delhi, India. (10437946)
1998
30
Gallbladder wall thickening in dengue hemorrhagic fever: an ultrasonographic study. (7673451)
1995
31
Dengue virus and endothelial cell: a related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever. (7886587)
1993
32
Emergence of epidemic dengue/dengue hemorrhagic fever as a public health problem in the Americas. (8012739)
1993
33
The first epidemic of dengue hemorrhagic fever in the People's Republic of China. (2042704)
1991
34
Dengue hemorrhagic fever in Cuba, 1981: a retrospective seroepidemiologic study. (2316788)
1990
35
International symposium on dengue and dengue hemorrhagic fever. Introduction. (1983048)
1990
36
Global epidemiology of dengue hemorrhagic fever. (2098928)
1990
37
Association of dengue hemorrhagic fever with the HLA system. (3498669)
1987
38
Dengue hemorrhagic fever--Puerto Rico. (3097497)
1986
39
Antibody-capture ELISA for detection of immunoglobulin M antibodies in sera from Japanese encephalitis and dengue hemorrhagic fever patients. (2989309)
1985
40
Atypical lymphocyte in dengue hemorrhagic fever: its value in diagnosis. (6740378)
1984
41
Surveillance of dengue hemorrhagic fever cases in Thailand. (7342320)
1981
42
Dengue hemorrhagic fever in Malaysia: the 1973 epidemic. (6105712)
1980
43
Early recognition of severe dengue hemorrhagic fever. (632709)
1978
44
Glomerular changes in dengue hemorrhagic fever. (786215)
1976
45
Immunofluorescent staining of the surfaces of lymphocytes in suspension from patients with dengue hemorrhagic fever. (61729)
1976
46
Dengue hemorrhagic fever: hospital reporting taken as an index of health education effectiveness. (140560)
1976
47
Indirect fluorescent antibody technic for demonstration of serum antibody in dengue hemorrhagic fever cases. (1099896)
1975
48
Detection of sporadic cases of dengue hemorrhagic fever. (5501443)
1970
49
Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. (5419206)
1970
50
Observations related to pathogenesis of dengue hemorrhagic fever. V. Examination of agspecific sequential infection rates using a mathematical model. (5419207)
1970

Variations for Dengue Hemorrhagic Fever

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Expression for genes affiliated with Dengue Hemorrhagic Fever

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LifeMap Discovery
Genes differentially expressed in tissues of Dengue Hemorrhagic Fever patients vs. healthy controls: 30 (show all 93)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CD38CD38 moleculeBlood+4.800.000
2IFI27interferon, alpha-inducible protein 27Blood+4.710.000
3RRM2ribonucleotide reductase M2Blood+4.630.000
4IGHMimmunoglobulin heavy constant muBlood+4.610.000
5BIRC5baculoviral IAP repeat containing 5Blood+4.470.000
6CAV1caveolin 1, caveolae protein, 22kDaBlood+4.410.000
7DLGAP5discs, large (Drosophila) homolog-associated protein 5Blood+4.310.000
8CEP55centrosomal protein 55kDaBlood+4.280.000
9XISTX inactive specific transcript (non-protein coding)Blood-4.250.009
10BUB1BUB1 mitotic checkpoint serine/threonine kinaseBlood+4.210.000
11SHCBP1SHC SH2-domain binding protein 1Blood+4.130.000
12PBKPDZ binding kinaseBlood+4.130.000
13IGKV3-20immunoglobulin kappa variable 3-20Blood+4.130.000
14TYMSthymidylate synthetaseBlood+4.070.000
15CDCA2cell division cycle associated 2Blood+4.060.000
16MKI67marker of proliferation Ki-67Blood+4.000.000
17CYAT1immunoglobulin lambda light chain-likeBlood+3.980.000
18MCM10minichromosome maintenance complex component 10Blood+3.980.000
19ZWINTZW10 interacting kinetochore proteinBlood+3.960.000
20PI3peptidase inhibitor 3, skin-derivedBlood-3.930.000
21CDK1cyclin-dependent kinase 1Blood+3.920.000
22HMMRhyaluronan-mediated motility receptor (RHAMM)Blood+3.900.000
23SESN3sestrin 3Blood-3.900.000
24SDC1syndecan 1Blood+3.890.000
25SPC25SPC25, NDC80 kinetochore complex componentBlood+3.840.000
26NCAPGnon-SMC condensin I complex, subunit GBlood+3.840.000
27TK1thymidine kinase 1, solubleBlood+3.820.000
28CDC20cell division cycle 20Blood+3.800.000
29TNFRSF17tumor necrosis factor receptor superfamily, member 17Blood+3.800.000
30DTLdenticleless E3 ubiquitin protein ligase homolog (Drosophila)Blood+3.800.000
31TOP2Atopoisomerase (DNA) II alpha 170kDaBlood+3.800.000
32GLDCglycine dehydrogenase (decarboxylating)Blood+3.750.000
33IGLJ3immunoglobulin lambda joining 3Blood+3.750.000
34KIF2Ckinesin family member 2CBlood+3.740.000
35CNTNAP3contactin associated protein-like 3Blood-3.720.000
36CDT1chromatin licensing and DNA replication factor 1Blood+3.720.000
37CDKN3cyclin-dependent kinase inhibitor 3Blood+3.710.000
38KIAA0101KIAA0101Blood+3.710.000
39EIF1AYeukaryotic translation initiation factor 1A, Y-linkedBlood+3.710.034
40NOVnephroblastoma overexpressedBlood-3.710.000
41CENPAcentromere protein ABlood+3.690.000
42TTKTTK protein kinaseBlood+3.670.000
43ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Blood+3.660.000
44KIF11kinesin family member 11Blood+3.640.000
45IGLimmunoglobulin lambda locusBlood+3.640.000
46CCNB2cyclin B2Blood+3.610.000
47BUB1BBUB1 mitotic checkpoint serine/threonine kinase BBlood+3.600.000
48OR2W3olfactory receptor, family 2, subfamily W, member 3Blood-3.510.000
49SELENBP1selenium binding protein 1Blood-3.500.000
50KIF11kinesin family member 11Blood+3.420.000
51E2F8E2F transcription factor 8Blood+3.410.000
52CCNA2cyclin A2Blood+3.400.000
53KCTD14potassium channel tetramerization domain containing 14Blood+3.400.000
54IGLimmunoglobulin lambda locusBlood+3.370.000
55IGLJ3immunoglobulin lambda joining 3Blood+3.350.000
56CDCA5cell division cycle associated 5Blood+3.310.000
57TPX2TPX2, microtubule-associatedBlood+3.310.000
58KIF20Akinesin family member 20ABlood+3.300.000
59E2F7E2F transcription factor 7Blood+3.280.000
60ANLNanillin, actin binding proteinBlood+3.280.000
61KDM5Dlysine (K)-specific demethylase 5DBlood+3.280.017
62JAZF1JAZF zinc finger 1Blood-3.270.000
63HJURPHolliday junction recognition proteinBlood+3.250.000
64IGKV3-20immunoglobulin kappa variable 3-20Blood+3.240.000
65KIF4Akinesin family member 4ABlood+3.220.000
66KIF15kinesin family member 15Blood+3.200.000
67CNTNAP3Bcontactin associated protein-like 3BBlood-3.190.000
68TNFRSF17tumor necrosis factor receptor superfamily, member 17Blood+3.190.000
69AURKBaurora kinase BBlood+3.180.000
70TRIP13thyroid hormone receptor interactor 13Blood+3.180.000
71CCND2cyclin D2Blood+3.170.000
72GINS1GINS complex subunit 1 (Psf1 homolog)Blood+3.160.000
73IGLV2-23immunoglobulin lambda variable 2-23Blood+3.150.000
74SLC6A8solute carrier family 6 (neurotransmitter transporter), member 8Blood-3.150.000
75KIF18Bkinesin family member 18BBlood+3.140.000
76OIP5Opa interacting protein 5Blood+3.140.000
77KRT1keratin 1Blood-3.120.001
78GGHgamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)Blood+3.110.000
79RAD51RAD51 recombinaseBlood+3.100.000
80GLDCglycine dehydrogenase (decarboxylating)Blood+3.100.000
81RAD51AP1RAD51 associated protein 1Blood+3.090.000
82DDX3YDEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linkedBlood+3.090.028
83MBNL3muscleblind-like splicing regulator 3Blood-3.090.000
84IGLV1-44immunoglobulin lambda variable 1-44Blood+3.090.000
85MCM4minichromosome maintenance complex component 4Blood+3.080.000
86IGLV4-60immunoglobulin lambda variable 4-60Blood+3.080.000
87FOXM1forkhead box M1Blood+3.060.000
88ESPL1extra spindle pole bodies homolog 1 (S. cerevisiae)Blood+3.060.000
89SLC4A1solute carrier family 4 (anion exchanger), member 1 (Diego blood group)Blood-3.050.000
90IGLV3-19immunoglobulin lambda variable 3-19Blood+3.040.000
91GTSE1G-2 and S-phase expressed 1Blood+3.040.000
92PDZK1IP1PDZK1 interacting protein 1Blood-3.020.000
93USP18ubiquitin specific peptidase 18Blood+3.000.000

Search GEO for disease gene expression data for Dengue Hemorrhagic Fever.

Pathways for genes affiliated with Dengue Hemorrhagic Fever

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Pathways related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL2 signaling events mediated by STAT536
9.9LTA, PTPN11
29.9LTA, CD40LG
39.2IFNA10, IFNA17, IFNA16
4
Show member pathways
8.9IFNA16, IFNA17, IFNA10, PTPN11
5
Show member pathways
8.9IFNA16, IFNA17, IFNA10, PTPN11
68.4IFNA13, IFNA10, IFNA17, IFNA16
7
Show member pathways
8.4IFNA16, IFNA17, IFNA10, IFNA13
88.4IFNA16, IFNA17, IFNA10, IFNA13
98.4IFNA13, IFNA10, IFNA17, IFNA16
108.4IFNA13, IFNA10, IFNA17, IFNA16
11
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.4IFNA13, IFNA10, IFNA17, IFNA16
128.1IFNA13, IFNA10, IFNA17, IFNA16, LTA
13
Show member pathways
8.1LTA, IFNA16, IFNA17, IFNA10, IFNA13
14
Show member pathways
Immune response CD16 signaling in NK cells58
8.1PTPN11, IFNA13, IFNA10, IFNA17, IFNA16
15
Show member pathways
8.1PTPN11, IFNA13, IFNA10, IFNA17, IFNA16
16
Show member pathways
7.8IFNA13, IFNA10, IFNA17, IFNA16, CD40LG, LTA
177.8IFNA13, IFNW1, IFNA10, IFNA17, IFNA16
18
Show member pathways
7.4IVNS1ABP, PTPN11, IFNA13, IFNA10, IFNA17, IFNA16
197.3IFNA13, IFNW1, IFNA10, IFNA17, IFNA16, IFNK
20
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
7.0PTPN11, IFNA13, IFNW1, IFNA10, IFNA17, IFNA16
21
Show member pathways
6.8IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
22
Show member pathways
Type III interferon signaling36
6.5IFNK, PTPN11, IFNA13, IFNW1, IFNE, IFNA10
23
Show member pathways
6.2IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16

Compounds for genes affiliated with Dengue Hemorrhagic Fever

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Compounds related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1okt3439.9LTA, CD40LG
2neopterin439.9LTA, CD40LG
3mycophenolate mofetil43 49 1211.8LTA, CD40LG
4herbimycin a43 5910.7LTA, CD40LG, PTPN11
5rantes439.7LTA, CD40LG, PTPN11
6acetylcholine43 49 28 24 1213.6PTPN11, CD40LG, LTA
7ivig439.6LTA, CD40LG

GO Terms for genes affiliated with Dengue Hemorrhagic Fever

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Cellular components related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.9IFNK, IFNA16, IFNA17, IFNA10, IFNA13
2extracellular spaceGO:00056155.9LTA, IFNA13, IFNW1, IFNE, IFNA10, IFNA17

Biological processes related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1response to virusGO:00096158.3IVNS1ABP, IFNW1, IFNA17, IFNK
2regulation of type I interferon-mediated signaling pathwayGO:00603388.2PTPN11, IFNA13, IFNA10, IFNA17, IFNA16
3blood coagulationGO:00075968.1IFNA16, IFNA17, IFNA10, IFNA13, PTPN11
4type I interferon signaling pathwayGO:00603378.0PTPN11, IFNA13, IFNA10, IFNA17, IFNA16
5regulation of MHC class I biosynthetic processGO:00453437.1IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
6positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:00331417.1IFNA17, IFNA16, IFNK, IFNA10, IFNE, IFNW1
7natural killer cell activation involved in immune responseGO:00023237.1IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
8T cell activation involved in immune responseGO:00022867.1IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
9response to exogenous dsRNAGO:00433307.1IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
10adaptive immune responseGO:00022507.0IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
11defense response to virusGO:00516076.9IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
12humoral immune responseGO:00069596.8IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
13B cell differentiationGO:00301836.7IFNW1, IFNE, IFNA10, IFNA17, IFNA16, IFNK
14B cell proliferationGO:00421006.7CD40LG, IFNA13, IFNK, IFNA16, IFNA17, IFNA10
15cytokine-mediated signaling pathwayGO:00192216.7PTPN11, IFNA13, IFNW1, IFNE, IFNA10, IFNA17
16innate immune responseGO:00450876.5PTPN11, IFNA13, IFNW1, IFNE, IFNA10, IFNA17

Molecular functions related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.9LTA, CD40LG
2type I interferon receptor bindingGO:00051326.5IFNA13, IFNW1, IFNE, IFNA10, IFNA17, IFNA16
3cytokine activityGO:00051256.1LTA, IFNA13, IFNW1, IFNE, IFNA10, IFNA17

Products for genes affiliated with Dengue Hemorrhagic Fever

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Sources for Dengue Hemorrhagic Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet