DHF
MCID: DNG002
MIFTS: 47

Dengue Hemorrhagic Fever (DHF) malady

Infectious diseases category

Summaries for Dengue Hemorrhagic Fever

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8Disease Ontology, 3CDC, 32MalaCards
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CDC:3 With more than one-third of the world’s population living in areas at risk for infection, dengue virus is a leading cause of illness and death in the tropics and subtropics. As many as 400 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are not yet any vaccines to prevent infection with dengue virus and the most effective protective measures are those that avoid mosquito bites. When infected, early recognition and prompt supportive treatment can substantially lower the risk of medical complications and death.

MalaCards: Dengue Hemorrhagic Fever, also known as DHF, is related to dengue disease and hepatitis, and has symptoms including high fever, reduction in the fluid part of the blood and thrombocytopenia. An important gene associated with Dengue Hemorrhagic Fever is PTPN11 (protein tyrosine phosphatase, non-receptor type 11), and among its related pathways are PEDF Induced Signaling and Jak-STAT signaling pathway. The compound herbimycin a have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and t cells.

Disease Ontology:8 A dengue disease that occurs when a person experiences a second infection with a heterologous dengue virus serotype, which is transmitted by aedes mosquito bite. the infection has symptom hemorrhagic lesions of the skin, has symptom thrombocytopenia, has symptom reduction in the fluid part of the blood, and has symptom high fever.

Aliases & Classifications for Dengue Hemorrhagic Fever

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

dengue hemorrhagic fever 8 44 60
dhf 8


External Ids:

Disease Ontology8 DOID:12206
NCIt39 C34683
MeSH34 D019595
ICD1025 A91

Related Diseases for Dengue Hemorrhagic Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Dengue Hemorrhagic Fever:



Diseases related to dengue hemorrhagic fever

Clinical Features for Dengue Hemorrhagic Fever

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8Disease Ontology
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Symptoms:

8
  • high fever
  • reduction in the fluid part of the blood
  • thrombocytopenia
  • hemorrhagic lesions of the skin

Drugs & Therapeutics for Dengue Hemorrhagic Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dengue Hemorrhagic Fever

Drug clinical trials:

Search ClinicalTrials for Dengue Hemorrhagic Fever

Search NIH Clinical Center for Dengue Hemorrhagic Fever

Search CenterWatch for Dengue Hemorrhagic Fever

Genetic Tests for Dengue Hemorrhagic Fever

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Anatomical Context for Dengue Hemorrhagic Fever

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32MalaCards
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MalaCards organs/tissues related to Dengue Hemorrhagic Fever:

32
Skin, Endothelial, T cells, Pituitary, Monocytes, Liver, Testes, Pancreas, B cells, Whole blood, Bone marrow, Bone, Kidney

Animal Models for Dengue Hemorrhagic Fever or affiliated genes

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Publications for Dengue Hemorrhagic Fever

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50PubMed
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Articles related to Dengue Hemorrhagic Fever:

(show top 50)    (show all 449)
idTitleAuthorsYear
1
The role of endothelial activation in dengue hemorrhagic fever and hantavirus pulmonary syndrome. (23841977)
2013
2
Femoral compressive neuropathy from iliopsoas haematoma complicating dengue hemorrhagic fever. (23608387)
2013
3
Watermelon stomach in dengue hemorrhagic fever. (23526505)
2013
4
Review of Dengue hemorrhagic fever fatal cases seen among adults: a retrospective study. (23658849)
2013
5
Outbreak of viral hemorrhagic fever caused by dengue virus type 3 in Al-Mukalla, Yemen. (23497142)
2013
6
Acute pancreatitis in dengue hemorrhagic fever. (22451187)
2012
7
Dengue hemorrhagic fever and severe thrombocytopenia in a patient on mandatory anticoagulation: balancing two life threatening conditions: a case report. (23098331)
2012
8
Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study. (20532230)
2010
9
Outcome of dengue hemorrhagic fever-caused acute kidney injury in Thai children. (20362302)
2010
10
Spatial-temporal patterns of dengue in areas at risk of dengue hemorrhagic fever in Kaohsiung, Taiwan, 2002. (19716331)
2010
11
Phenotypic analysis of dengue virus isolates associated with dengue fever and dengue hemorrhagic fever for cellular attachment, replication and interferon signaling ability. (19540887)
2009
12
Isolation and characterization of two phenotypically distinct dengue type-2 virus isolates from the same dengue hemorrhagic Fever patient. (19762982)
2009
13
Dengue virus serotype 2 from a sylvatic lineage isolated from a patient with dengue hemorrhagic fever. (19399166)
2009
14
Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults. (18282738)
2008
15
Dengue hemorrhagic fever transmitted by blood transfusion. (18832256)
2008
16
Acute acalculous cholecystitis in dengue hemorrhagic fever. (18025749)
2007
17
Analysis of repeat hospital admissions for dengue to estimate the frequency of third or fourth dengue infections resulting in admissions and dengue hemorrhagic fever, and serotype sequences. (17984352)
2007
18
Hyperlipasemia/pancreatitis in adults with dengue hemorrhagic fever. (18090250)
2007
19
Thrombocytopenia associated with dengue hemorrhagic fever responds to intravenous administration of anti-D (Rh(0)-D) immune globulin. (17426181)
2007
20
Idiopathic purpura fulminans in dengue hemorrhagic fever. (17679737)
2007
21
The emergence of epidemic dengue fever and dengue hemorrhagic fever in the Americas: a case of failed public health policy. (15969972)
2005
22
Classical dengue hemorrhagic fever resulting from two dengue infections spaced 20 years or more apart: Havana, Dengue 3 epidemic, 2001-2002. (16023878)
2005
23
Clinical profile of dengue hemorrhagic fever cases in Mexico. (16104461)
2005
24
Dengue and dengue hemorrhagic fever, Brazil, 1981-2002. (15705322)
2005
25
Dengue fever and dengue hemorrhagic fever: a review of the history, transmission, treatment, and prevention. (15685151)
2005
26
Dual infection: dengue hemorrhagic fever with unusual manifestations and mycoplasma pneumonia in a child. (15691145)
2004
27
Serious thrombocytopenia due to dengue hemorrhagic fever treated with high dosages of immunoglobulin. (12802766)
2003
28
Changes in the plasma lipid profile as a potential predictor of clinical outcome in dengue hemorrhagic fever. (11915007)
2002
29
Desmopressin treatment for a case of dengue hemorrhagic fever/dengue shock syndrome. (11588706)
2001
30
Assessment of dengue hemorrhagic fever in Myanmar. (11414403)
2000
31
Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis. (10865168)
2000
32
Changing epidemiology of dengue hemorrhagic fever in Thailand. (10098800)
1999
33
Neurological manifestations in dengue hemorrhagic fever. (7896395)
1994
34
Epidemiology of dengue/dengue hemorrhagic fever in Malaysia--a retrospective epidemiological study 1973-1987. Part I: Dengue hemorrhagic fever (DHF). (1308765)
1992-1993
35
The first epidemic of dengue hemorrhagic fever in the People's Republic of China. (2042704)
1991
36
International symposium on dengue and dengue hemorrhagic fever. Introduction. (1983048)
1990
37
Platelet function during the acute phase of dengue hemorrhagic fever. (2772702)
1989
38
Dengue hemorrhagic fever (DHF). DHF situation and activities in the WHO South-East Asia Region in 1988. (2766388)
1989
39
Natural killer cells in dengue hemorrhagic fever/dengue shock syndrome. (3064759)
1988
40
Alterations in thrombopoiesis in patients with thrombocytopenia produced by dengue hemorrhagic fever. (3808936)
1986
41
Delayed-type hypersensitivity: probable role in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome. (6844807)
1983
42
Demonstration of dengue antibody complexes on the surface of platelets from patients with dengue hemorrhagic fever. (384817)
1979
43
Epidemic dengue hemorrhagic fever in rural Indonesia. II. Clinical studies. (464192)
1979
44
Early recognition of severe dengue hemorrhagic fever. (632709)
1978
45
The Emperor's New Clothes revisited, or reflections on the pathogenesis of dengue hemorrhagic fever. (869095)
1977
46
A report on dengue hemorrhagic fever patients with viral isolation. (1196649)
1975
47
Evaluation of the plasma kinin system in dengue hemorrhagic fever. (1151158)
1975
48
Studies on dengue hemorrhagic fever. II. Electrolyte study. (4685995)
1973
49
Recovery of dengue-4 viruses from mosquito vectors and patients during an epidemic of dengue hemorrhagic fever. (5795450)
1969
50
An insular outbreak of dengue hemorrhagic fever. II. Virologic and serologic studies. (4970512)
1968

Genetic Variations for Dengue Hemorrhagic Fever

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Expression for genes affiliated with Dengue Hemorrhagic Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dengue Hemorrhagic Fever

Search GEO for disease gene expression data for Dengue Hemorrhagic Fever.

Pathways for genes affiliated with Dengue Hemorrhagic Fever

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51QIAGEN, 29KEGG, 52R&D Systems, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7IFNE, IFNA17, IFNA21, IFNA4, IFNA8, IFNW1
210.6IFNK, IFNA16, IFNA10, IFNA14, IFNE, IFNA17
3
Hide members
10.6IFNA4, IFNA8, IFNA5, IFNA13, IFNA6, IVNS1ABP
4
Hide members
10.6IFNA21, IFNA4, IFNA8, IFNW1, IFNA5, IFNA13
5
Hide members
10.6IFNE, IFNA17, IFNA21, IFNA4, IFNA8, IFNW1
6
Hide members
10.6IFNA17, IFNA21, IFNA4, IFNA8, IFNA5, IFNA13
7
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
810.6IFNK, IFNA16, IFNA10, IFNA14, IFNA17, IFNA21
9
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
10
Immune response IFN alpha/beta signaling pathway
Hide members
10.6PTPN11, IFNA6, IFNA13, IFNA5, IFNA16, IFNA10
11
Hide members
10.6IFNA17, IFNA14, IFNA10, IFNA16, IFNA21, IFNA4
1210.6IFNA8, IFNA5, IFNA13, IFNA6, LTA, IFNA4
13
Hide members
10.6TLR8, IFNA16, IFNA10, IFNA14, IFNA17, IFNA21
1410.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
15
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
16
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.6IFNA6, IFNA13, IFNA16, IFNA10, IFNA14, IFNA17
1710.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
1810.6IFNA14, IFNA17, IFNA21, IFNA4, IFNA8, IFNA5
1910.6IFNA17, IFNA14, IFNA10, IFNA16, IFNA21, IFNA4
2010.6IFNA4, IFNA8, IFNA5, IFNA13, IFNA6, IFNA21
2110.6IFNA10, IFNA14, IFNA17, IFNA21, IFNA4, IFNA8
22
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2310.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2410.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4

Compounds for genes affiliated with Dengue Hemorrhagic Fever

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44Novoseek, 59Tocris Bioscience
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Compounds related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1herbimycin a44 5911.5PTPN11, CD40LG, LTA

GO Terms for genes affiliated with Dengue Hemorrhagic Fever

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16Gene Ontology
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Cellular components related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2extracellular spaceGO:00561510.4CD40LG, IFNK, IFNA16, IFNA10, IFNA14, IFNE

Biological processes related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon-mediated signaling pathwayGO:06033810.8IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2type I interferon-mediated signaling pathwayGO:06033710.8IFNA14, IFNA17, IFNA21, IFNA4, IFNA8, IFNA5
3cytokine-mediated signaling pathwayGO:01922110.7IFNK, IFNA16, IFNA10, IFNA14, IFNA17, IFNA21
4defense response to virusGO:05160710.7IFNA14, IFNE, IFNA17, IFNA21, IFNA4, IFNA8
5innate immune responseGO:04508710.6IFNA17, IFNA14, IFNA10, IFNA16, TLR8, IFNA21
6blood coagulationGO:00759610.5IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
7positive regulation of innate immune responseGO:04508910.5IFNK, TLR8
8response to virusGO:00961510.3TLR8, IFNK, IFNA17, IFNA4, IFNW1, IFNA6

Molecular functions related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7CD40LG, IFNA16, IFNK, IFNA10, IFNA14, LTA
2tumor necrosis factor receptor bindingGO:00516410.5CD40LG, LTA
3cytokine receptor bindingGO:00512610.5IFNA6, IFNA5, IFNW1, IFNA8, IFNA21, IFNE
4interferon-alpha/beta receptor bindingGO:00513210.2IFNK, IFNA16, IFNA17, IFNA4, IFNA13

Products for genes affiliated with Dengue Hemorrhagic Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dengue Hemorrhagic Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet