DHF
MCID: DNG002
MIFTS: 47

Dengue Hemorrhagic Fever (DHF) malady

Infectious diseases category

Summaries for Dengue Hemorrhagic Fever

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8Disease Ontology, 3CDC, 32MalaCards
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CDC:3 With more than one-third of the world’s population living in areas at risk for infection, dengue virus is a leading cause of illness and death in the tropics and subtropics. As many as 400 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are not yet any vaccines to prevent infection with dengue virus and the most effective protective measures are those that avoid mosquito bites. When infected, early recognition and prompt supportive treatment can substantially lower the risk of medical complications and death.

MalaCards: Dengue Hemorrhagic Fever, also known as DHF, is related to dengue disease and hepatitis, and has symptoms including reduction in the fluid part of the blood, hemorrhagic lesions of the skin and high fever. An important gene associated with Dengue Hemorrhagic Fever is PTPN11 (protein tyrosine phosphatase, non-receptor type 11), and among its related pathways are PEDF Induced Signaling and Jak-STAT signaling pathway. The compound herbimycin a have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and t cells.

Disease Ontology:8 A dengue disease that occurs when a person experiences a second infection with a heterologous dengue virus serotype, which is transmitted by aedes mosquito bite. the infection has symptom hemorrhagic lesions of the skin, has symptom thrombocytopenia, has symptom reduction in the fluid part of the blood, and has symptom high fever.

Aliases & Classifications for Dengue Hemorrhagic Fever

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

dengue hemorrhagic fever 8 44 60
dhf 8


External Ids:

Disease Ontology8 DOID:12206
NCIt39 C34683
MeSH34 D019595
ICD1025 A91

Related Diseases for Dengue Hemorrhagic Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Dengue Hemorrhagic Fever:



Diseases related to dengue hemorrhagic fever

Clinical Features for Dengue Hemorrhagic Fever

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8Disease Ontology
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Symptoms:

8
  • reduction in the fluid part of the blood
  • hemorrhagic lesions of the skin
  • high fever
  • thrombocytopenia

Drugs & Therapeutics for Dengue Hemorrhagic Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dengue Hemorrhagic Fever

Drug clinical trials:

Search ClinicalTrials for Dengue Hemorrhagic Fever

Search NIH Clinical Center for Dengue Hemorrhagic Fever

Search CenterWatch for Dengue Hemorrhagic Fever

Genetic Tests for Dengue Hemorrhagic Fever

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Anatomical Context for Dengue Hemorrhagic Fever

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32MalaCards
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MalaCards organs/tissues related to Dengue Hemorrhagic Fever:

32
Skin, Endothelial, T cells, Pituitary, Monocytes, Liver, Pancreas, Testes, B cells, Whole blood, Bone marrow, Kidney, Bone

Animal Models for Dengue Hemorrhagic Fever or affiliated genes

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Publications for Dengue Hemorrhagic Fever

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50PubMed
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Articles related to Dengue Hemorrhagic Fever:

(show top 50)    (show all 449)
idTitleAuthorsYear
1
Dengue hemorrhagic fever presenting with hemorrhagic pancreatitis and an intramural hematoma of the duodenal wall: a case report and review of the literature. (24050071)
2013
2
Acute gingival bleeding as a complication of dengue hemorrhagic fever. (24174736)
2013
3
Temporal patterns and a disease forecasting model of dengue hemorrhagic fever in Jakarta based on 10 years of surveillance data. (23691630)
2013
4
Immunopathogenesis of dengue hemorrhagic fever: Contribution to the study of human liver lesions. (24114877)
2013
5
Dengue hemorrhagic fever in Trinidad and Tobago: a case for a conservative approach to platelet transfusion. (22403331)
2012
6
Unilateral massive hemothorax in Dengue hemorrhagic fever: a unique presentation. (22805731)
2012
7
Discovery proteomics and nonparametric modeling pipeline in the development of a candidate biomarker panel for dengue hemorrhagic fever. (22376251)
2012
8
Dengue hemorrhagic fever outbreak in children in Port Sudan. (21338953)
2011
9
Filgrastim as a rescue therapy for persistent neutropenia in a case of dengue hemorrhagic Fever with acute respiratory distress syndrome and myocarditis. (22606398)
2011
10
Crimean-Congo hemorrhagic fever in a dengue-endemic region: lessons for the future. (20818095)
2010
11
Agranulocytosis in dengue hemorrhagic fever: a neglected condition. (20462096)
2010
12
Dengue fever and dengue hemorrhagic fever. (19561427)
2009
13
Imported dengue hemorrhagic fever, Europe. (18680677)
2008
14
Decreases in dengue transmission may act to increase the incidence of dengue hemorrhagic fever. (18250338)
2008
15
The economic impact of dengue hemorrhagic fever on family level in Southern Vietnam. (17521539)
2007
16
Chest radiographic presentation in patients with dengue hemorrhagic Fever. (17690401)
2007
17
The pathology of dengue hemorrhagic fever. (18085063)
2007
18
Dengue and dengue hemorrhagic fever in the State of Pernambuco, 1995-2006. (18200409)
2007
19
Fatal dengue hemorrhagic fever in adults during a dengue epidemic in Singapore. (16899384)
2007
20
Relationship between body size and severity of dengue hemorrhagic fever among children aged 0-14 years. (17124987)
2006
21
The differences of dengue vectors and human behavior between families with and without members having dengue fever/dengue hemorrhagic fever. (16175742)
2005
22
Epidemiology of dengue and dengue hemorrhagic fever in a cohort of adults living in Bandung, West Java, Indonesia. (15728868)
2005
23
The correlation between coagulation test and albumin with antithrombin III in Dengue hemorrhagic fever. (15931699)
2004
24
Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. (14722886)
2004
25
Modeling of hemoglobin in dengue fever and dengue hemorrhagic fever using bioelectrical impedance. (15253113)
2004
26
Susceptibility to dengue hemorrhagic fever in vietnam: evidence of an association with variation in the vitamin d receptor and Fc gamma receptor IIa genes. (12363051)
2002
27
The dengue and dengue hemorrhagic fever epidemic in Puerto Rico, 1994-1995. (11425166)
2001
28
Strong HLA class I--restricted T cell responses in dengue hemorrhagic fever: a double-edged sword? (11709777)
2001
29
Concomitant dengue hemorrhagic fever with Kawasaki disease. (11023092)
2000
30
Sonographic findings in grade III dengue hemorrhagic fever in adults. (10602103)
2000
31
A clinical study of the patients with dengue hemorrhagic fever during the epidemic of 1996 at Lucknow, India. (10928368)
1999
32
Dengue hemorrhagic fever: clinical manifestations and management. (10798041)
1999
33
The first major outbreak of dengue hemorrhagic fever in Delhi, India. (10458971)
1999
34
Dengue hemorrhagic fever during pregnancy: antepartum, intrapartum and postpartum management. (9392910)
1997
35
Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndrome. (8032282)
1994
36
The epidemiology, prevention and control of dengue hemorrhagic fever in Indonesia. (7844837)
1994
37
High rate of reactivation of human herpesvirus 6 in children with dengue hemorrhagic fever. (8077742)
1994
38
Antibodies against dengue viral proteins in primary and secondary dengue hemorrhagic fever. (2063952)
1991
39
Global epidemiology of dengue hemorrhagic fever. (2098928)
1990
40
Hemostatic defects in dengue hemorrhagic fever. (2665014)
1989
41
Clinical and serologic study of Cuban children with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). (3442718)
1987
42
Dengue and dengue hemorrhagic fever in the Americas. (3313490)
1987
43
Atypical lymphocyte in dengue hemorrhagic fever: its value in diagnosis. (6740378)
1984
44
Platelet function in dengue hemorrhagic fever. (6414218)
1983
45
Dengue hemorrhagic fever: hospital reporting taken as an index of health education effectiveness. (140560)
1976
46
Observations on hospitalized patients with dengue hemorrhagic fever. (1196646)
1975
47
Dengue hemorrhagic fever: problems and progress. (1181545)
1975
48
Renal involvement and reticulo-endothelial-system clearance in dengue hemorrhagic fever. (4685998)
1973
49
Dengue hemorrhagic fever (literature review and report of 14 cases). (5032318)
1972
50
Observations related to pathogensis of dengue hemorrhagic fever. VI. Hypotheses and discussion. (5419208)
1970

Genetic Variations for Dengue Hemorrhagic Fever

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Expression for genes affiliated with Dengue Hemorrhagic Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dengue Hemorrhagic Fever

Search GEO for disease gene expression data for Dengue Hemorrhagic Fever.

Pathways for genes affiliated with Dengue Hemorrhagic Fever

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51QIAGEN, 29KEGG, 52R&D Systems, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7IFNE, IFNA17, IFNA21, IFNA4, IFNA8, IFNW1
210.6IFNK, IFNA16, IFNA10, IFNA14, IFNE, IFNA17
3
Hide members
10.6IFNA4, IFNA8, IFNA5, IFNA13, IFNA6, IVNS1ABP
4
Hide members
10.6IFNA21, IFNA4, IFNA8, IFNW1, IFNA5, IFNA13
5
Hide members
10.6IFNE, IFNA17, IFNA21, IFNA4, IFNA8, IFNW1
6
Hide members
10.6IFNA17, IFNA21, IFNA4, IFNA8, IFNA5, IFNA13
7
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
810.6IFNK, IFNA16, IFNA10, IFNA14, IFNA17, IFNA21
9
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
10
Immune response IFN alpha/beta signaling pathway
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10.6PTPN11, IFNA6, IFNA13, IFNA5, IFNA16, IFNA10
11
Hide members
10.6IFNA17, IFNA14, IFNA10, IFNA16, IFNA21, IFNA4
1210.6IFNA8, IFNA5, IFNA13, IFNA6, LTA, IFNA4
13
Hide members
10.6TLR8, IFNA16, IFNA10, IFNA14, IFNA17, IFNA21
1410.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
15
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
16
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.6IFNA6, IFNA13, IFNA16, IFNA10, IFNA14, IFNA17
1710.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
1810.6IFNA14, IFNA17, IFNA21, IFNA4, IFNA8, IFNA5
1910.6IFNA17, IFNA14, IFNA10, IFNA16, IFNA21, IFNA4
2010.6IFNA4, IFNA8, IFNA5, IFNA13, IFNA6, IFNA21
2110.6IFNA10, IFNA14, IFNA17, IFNA21, IFNA4, IFNA8
22
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2310.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2410.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4

Compounds for genes affiliated with Dengue Hemorrhagic Fever

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44Novoseek, 59Tocris Bioscience
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Compounds related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1herbimycin a44 5911.5PTPN11, CD40LG, LTA

GO Terms for genes affiliated with Dengue Hemorrhagic Fever

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16Gene Ontology
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Cellular components related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2extracellular spaceGO:00561510.4CD40LG, IFNK, IFNA16, IFNA10, IFNA14, IFNE

Biological processes related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon-mediated signaling pathwayGO:06033810.8IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2type I interferon-mediated signaling pathwayGO:06033710.8IFNA14, IFNA17, IFNA21, IFNA4, IFNA8, IFNA5
3cytokine-mediated signaling pathwayGO:01922110.7IFNK, IFNA16, IFNA10, IFNA14, IFNA17, IFNA21
4defense response to virusGO:05160710.7IFNA14, IFNE, IFNA17, IFNA21, IFNA4, IFNA8
5innate immune responseGO:04508710.6IFNA17, IFNA14, IFNA10, IFNA16, TLR8, IFNA21
6blood coagulationGO:00759610.5IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
7positive regulation of innate immune responseGO:04508910.5IFNK, TLR8
8response to virusGO:00961510.3TLR8, IFNK, IFNA17, IFNA4, IFNW1, IFNA6

Molecular functions related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7CD40LG, IFNA16, IFNK, IFNA10, IFNA14, LTA
2tumor necrosis factor receptor bindingGO:00516410.5CD40LG, LTA
3cytokine receptor bindingGO:00512610.5IFNA6, IFNA5, IFNW1, IFNA8, IFNA21, IFNE
4interferon-alpha/beta receptor bindingGO:00513210.2IFNK, IFNA16, IFNA17, IFNA4, IFNA13

Products for genes affiliated with Dengue Hemorrhagic Fever

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  • Antibodies
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Sources for Dengue Hemorrhagic Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet