DHF
MCID: DNG002
MIFTS: 45

Dengue Hemorrhagic Fever (DHF) malady

Infectious category

Summaries for Dengue Hemorrhagic Fever

Sources:
8Disease Ontology, 3CDC, 33MalaCards
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CDC:3 With more than one-third of the world’s population living in areas at risk for infection, dengue virus is a leading cause of illness and death in the tropics and subtropics. As many as 400 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are not yet any vaccines to prevent infection with dengue virus and the most effective protective measures are those that avoid mosquito bites. When infected, early recognition and prompt supportive treatment can substantially lower the risk of medical complications and death.

MalaCards: Dengue Hemorrhagic Fever, also known as DHF, is related to hemorrhagic fever and hepatitis c, and has symptoms including thrombocytopenia, high fever and hemorrhagic lesions of the skin. An important gene associated with Dengue Hemorrhagic Fever is PTPN11 (protein tyrosine phosphatase, non-receptor type 11), and among its related pathways are PEDF Induced Signaling and Jak-STAT signaling pathway. The compound herbimycin a have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and kidney.

Disease Ontology:8 A dengue disease that occurs when a person experiences a second infection with a heterologous dengue virus serotype, which is transmitted by aedes mosquito bite. the infection has symptom hemorrhagic lesions of the skin, has symptom thrombocytopenia, has symptom reduction in the fluid part of the blood, and has symptom high fever.

Aliases & Classifications for Dengue Hemorrhagic Fever

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

dengue hemorrhagic fever 8 45 61
dhf 8


External Ids:

Disease Ontology8 DOID:12206
NCIt40 C34683
MeSH35 D019595
ICD1025 A91

Related Diseases for Dengue Hemorrhagic Fever

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Dengue Hemorrhagic Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhagic fever32.3CD40LG
2hepatitis c30.3IFNA17, IFNA21, IVNS1ABP, CD40LG, PTPN11
3japanese encephalitis30.3PTPN11, IVNS1ABP
4dengue shock syndrome10.9
5thrombocytopenia10.8
6viral hemorrhagic fever10.6
7acute pancreatitis10.4
8n syndrome10.4
9char syndrome10.4
10dengue fever, protection against10.4
11acalculous cholecystitis10.4
12q fever10.4
13pituitary apoplexy10.4
14acute myocarditis10.4
15diastolic heart failure10.4
16acute liver failure10.2
17diabetic ketoacidosis10.2
18brazilian hemorrhagic fever10.2
19acute disseminated encephalomyelitis10.2
20acquired immunodeficiency syndrome10.2
21hepatitis d10.2
22femoral neuropathy10.2
23adult syndrome10.2
24typhoid fever10.2
25hantavirus pulmonary syndrome10.2
26kawasaki disease10.2
27hepatitis a10.2
28b cell deficiency10.2
29thalassemia10.2
30vasculitis10.2
31idiopathic edema10.2
32granulocytopenia10.2
33mannose-binding lectin deficiency10.2
34bacteremia10.2
35purpura fulminans10.2
36diffuse alveolar hemorrhage10.2
37storm syndrome10.0
38influenza10.0TLR8, IVNS1ABP, LTA, PTPN11
39measles10.0CD40LG
40viral infectious disease10.0TLR8, IFNK, IVNS1ABP, LTA, CD40LG, PTPN11
41melanoma10.0IFNA21, PTPN11
42hepatitis10.0CD40LG, LTA
43hepatitis b10.0IFNA21, IFNA17
44dengue disease10.0PTPN11, CD40LG, IVNS1ABP
45lupus erythematosus10.0CD40LG
46st. louis encephalitis10.0IFNA8
47selective iga deficiency disease10.0LTA, CD40LG
48hypersensitivity reaction type ii disease10.0PTPN11
49agammaglobulinemia10.0CD40LG, LTA
50rubella10.0CD40LG

Graphical network of the top 20 diseases related to Dengue Hemorrhagic Fever:



Diseases related to dengue hemorrhagic fever

Clinical Features for Dengue Hemorrhagic Fever

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 4)
  • thrombocytopenia
  • high fever
  • hemorrhagic lesions of the skin
  • reduction in the fluid part of the blood

Drugs & Therapeutics for Dengue Hemorrhagic Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Dengue Hemorrhagic Fever

Drug clinical trials:

Search ClinicalTrials for Dengue Hemorrhagic Fever

Search NIH Clinical Center for Dengue Hemorrhagic Fever

Search CenterWatch for Dengue Hemorrhagic Fever

Genetic Tests for Dengue Hemorrhagic Fever

Anatomical Context for Dengue Hemorrhagic Fever

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Dengue Hemorrhagic Fever:

33
Skin, Liver, Kidney, Bone marrow, Whole blood, Pancreas, Monocytes, T cells, B cells, Endothelial, Pituitary

Animal Models for Dengue Hemorrhagic Fever or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Dengue Hemorrhagic Fever

Sources:
51PubMed
See all sources

Articles related to Dengue Hemorrhagic Fever:

(show top 50)    (show all 448)
idTitleAuthorsYear
1
Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome. (24305068)
2013
2
Acute gingival bleeding as a complication of dengue hemorrhagic fever. (24174736)
2013
3
Immunopathogenesis of dengue hemorrhagic fever: Contribution to the study of human liver lesions. (24114877)
2013
4
Dengue hemorrhagic fever-associated immunomediators induced via maturation of dengue virus nonstructural 4B protein in monocytes modulate endothelial cell adhesion molecules and human microvascular endothelial cells permeability. (22129847)
2012
5
Validation of probability equation and decision tree in predicting subsequent dengue hemorrhagic fever in adult dengue inpatients in Singapore. (22049054)
2011
6
Dengue hemorrhagic fever outbreak in children in Port Sudan. (21338953)
2011
7
Tumor necrosis factor-alpha, transforming growth factor-I^1, and interleukin-10 gene polymorphisms: implication in protection or susceptibility to dengue hemorrhagic fever. (20732366)
2010
8
Crimean-Congo hemorrhagic fever in a dengue-endemic region: lessons for the future. (20818095)
2010
9
Acute myocarditis in dengue hemorrhagic fever: a case report and review of cardiac complications in dengue-affected patients. (20851651)
2010
10
Agranulocytosis in dengue hemorrhagic fever: a neglected condition. (20462096)
2010
11
Hemophagocytic syndrome associated with dengue hemorrhagic fever. (19556676)
2009
12
Co-circulations of two genotypes of dengue virus in 2006 out-break of dengue hemorrhagic fever in Karachi, Pakistan. (18639489)
2008
13
Imported dengue hemorrhagic fever, Europe. (18680677)
2008
14
Dengue and dengue hemorrhagic fever. (17539050)
2007
15
The pathology of dengue hemorrhagic fever. (18085063)
2007
16
Myocardial depression in dengue hemorrhagic fever: prevalence and clinical description. (17906598)
2007
17
Dengue and dengue hemorrhagic fever in the State of Pernambuco, 1995-2006. (18200409)
2007
18
Fatal dengue hemorrhagic fever in adults during a dengue epidemic in Singapore. (16899384)
2007
19
Dengue hemorrhagic fever with special emphasis on immunopathogenesis. (17645944)
2007
20
Relationship between body size and severity of dengue hemorrhagic fever among children aged 0-14 years. (17124987)
2006
21
Haemostatic disorder in Dengue hemorrhagic fever. (15931698)
2004
22
High levels of plasma dengue viral load during defervescence in patients with dengue hemorrhagic fever: implications for pathogenesis. (12573578)
2003
23
Coagulation abnormalities in dengue hemorrhagic Fever: serial investigations in 167 Vietnamese children with Dengue shock syndrome. (12115093)
2002
24
Epidemiology of dengue in Sri Lanka before and after the emergence of epidemic dengue hemorrhagic fever. (12224589)
2002
25
Susceptibility to dengue hemorrhagic fever in vietnam: evidence of an association with variation in the vitamin d receptor and Fc gamma receptor IIa genes. (12363051)
2002
26
Gall bladder wall edema in serology proven pediatric dengue hemorrhagic fever: a useful diagnostic finding which may help in prognostication. (10893923)
2000
27
Editorial response: Resuscitation of patients with dengue hemorrhagic fever/dengue shock syndrome. (10589890)
1999
28
Dengue hemorrhagic fever: clinical manifestations and management. (10798041)
1999
29
The first reported outbreak of dengue hemorrhagic fever in Irian Jaya, Indonesia. (9242317)
1997
30
Dengue hemorrhagic fever during pregnancy: antepartum, intrapartum and postpartum management. (9392910)
1997
31
Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndrome. (8032282)
1994
32
High rate of reactivation of human herpesvirus 6 in children with dengue hemorrhagic fever. (8077742)
1994
33
Nutritional status of children with dengue hemorrhagic fever. (8443312)
1993
34
Hyperventilation in children with dengue hemorrhagic fever (DHF). (1780163)
1991
35
Surveillance for dengue and dengue hemorrhagic fever. (2611461)
1989
36
Hemostatic defects in dengue hemorrhagic fever. (2665014)
1989
37
Dengue hemorrhagic fever: a case report with acute hepatic failure, protracted hypocalcemia, hyperamylasemia and an enlargement of pancreas. (2470849)
1988
38
Leads from the MMWR. Dengue and dengue hemorrhagic fever in the Americas, 1986. (2449549)
1988
39
Association of dengue hemorrhagic fever with the HLA system. (3498669)
1987
40
Proceedings of the SEAMO-TROPMED technical meeting on the pathogenesis and management of dengue hemorrhagic fever in Southeast Asia, Bangkok, 1986. (3433156)
1987
41
Clinical observations on hospitalized patients with virologically confirmed dengue hemorrhagic fever in Jakarta, Indonesia 1975-1983. (3774341)
1986
42
Platelet function in dengue hemorrhagic fever. (6414218)
1983
43
Surveillance of dengue hemorrhagic fever cases in Thailand. (7342320)
1981
44
Absence of leukocytes permissive to dengue 2 virus in the acute phase of dengue hemorrhagic fever. (453450)
1979
45
Fibrinogen metabolism and disseminated intravascular coagulation in dengue hemorrhagic fever. (869104)
1977
46
Studies on dengue hemorrhagic fever. IV. Fluorescence staining of the immune complexes on platelets. (71334)
1977
47
Observations on hospitalized patients with dengue hemorrhagic fever. (1196646)
1975
48
Dengue hemorrhagic fever: problems and progress. (1181545)
1975
49
Dengue hemorrhagic fever--do we know its cause? (4567852)
1973
50
Observations related to pathogenesis of dengue hemorrhagic fever. V. Examination of agspecific sequential infection rates using a mathematical model. (5419207)
1970

Genetic Variations for Dengue Hemorrhagic Fever

Expression for genes affiliated with Dengue Hemorrhagic Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dengue Hemorrhagic Fever

Search GEO for disease gene expression data for Dengue Hemorrhagic Fever.

Pathways for genes affiliated with Dengue Hemorrhagic Fever

Sources:
52QIAGEN, 30KEGG, 53R&D Systems, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7IFNE, IFNA17, IFNA21, IFNA4, IFNA8, IFNW1
210.6IFNK, IFNA16, IFNA10, IFNA14, IFNE, IFNA17
3
Hide members
10.6IFNA4, IFNA8, IFNA5, IFNA13, IFNA6, IVNS1ABP
4
Hide members
10.6IFNA21, IFNA4, IFNA8, IFNW1, IFNA5, IFNA13
5
Hide members
10.6IFNE, IFNA17, IFNA21, IFNA4, IFNA8, IFNW1
6
Hide members
10.6IFNA17, IFNA21, IFNA4, IFNA8, IFNA5, IFNA13
7
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
810.6IFNK, IFNA16, IFNA10, IFNA14, IFNA17, IFNA21
9
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
10
Immune response IFN alpha/beta signaling pathway
Hide members
10.6PTPN11, IFNA6, IFNA13, IFNA5, IFNA16, IFNA10
11
Hide members
10.6IFNA17, IFNA14, IFNA10, IFNA16, IFNA21, IFNA4
1210.6IFNA8, IFNA5, IFNA13, IFNA6, LTA, IFNA4
13
Hide members
10.6TLR8, IFNA16, IFNA10, IFNA14, IFNA17, IFNA21
1410.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
15
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
16
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
10.6IFNA6, IFNA13, IFNA16, IFNA10, IFNA14, IFNA17
1710.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
1810.6IFNA14, IFNA17, IFNA21, IFNA4, IFNA8, IFNA5
1910.6IFNA17, IFNA14, IFNA10, IFNA16, IFNA21, IFNA4
2010.6IFNA4, IFNA8, IFNA5, IFNA13, IFNA6, IFNA21
2110.6IFNA10, IFNA14, IFNA17, IFNA21, IFNA4, IFNA8
22
Hide members
10.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2310.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2410.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4

Compounds for genes affiliated with Dengue Hemorrhagic Fever

Sources:
45Novoseek, 60Tocris Bioscience
See all sources

Compounds related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1herbimycin a45 6011.5PTPN11, CD40LG, LTA

GO Terms for genes affiliated with Dengue Hemorrhagic Fever

Sources:
16Gene Ontology
See all sources

Cellular components related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2extracellular spaceGO:00561510.4CD40LG, IFNK, IFNA16, IFNA10, IFNA14, IFNE

Biological processes related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1regulation of type I interferon-mediated signaling pathwayGO:06033810.8IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
2type I interferon-mediated signaling pathwayGO:06033710.8IFNA14, IFNA17, IFNA21, IFNA4, IFNA8, IFNA5
3cytokine-mediated signaling pathwayGO:01922110.7IFNK, IFNA16, IFNA10, IFNA14, IFNA17, IFNA21
4defense response to virusGO:05160710.7IFNA14, IFNE, IFNA17, IFNA21, IFNA4, IFNA8
5innate immune responseGO:04508710.6IFNA17, IFNA14, IFNA10, IFNA16, TLR8, IFNA21
6blood coagulationGO:00759610.5IFNA16, IFNA10, IFNA14, IFNA17, IFNA21, IFNA4
7positive regulation of innate immune responseGO:04508910.5IFNK, TLR8
8response to virusGO:00961510.3TLR8, IFNK, IFNA17, IFNA4, IFNW1, IFNA6

Molecular functions related to Dengue Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7CD40LG, IFNA16, IFNK, IFNA10, IFNA14, LTA
2tumor necrosis factor receptor bindingGO:00516410.5CD40LG, LTA
3cytokine receptor bindingGO:00512610.5IFNA6, IFNA5, IFNW1, IFNA8, IFNA21, IFNE
4interferon-alpha/beta receptor bindingGO:00513210.2IFNK, IFNA16, IFNA17, IFNA4, IFNA13

Products for genes affiliated with Dengue Hemorrhagic Fever

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dengue Hemorrhagic Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet