Aliases & Classifications for Dengue Hemorrhagic Fever

MalaCards integrated aliases for Dengue Hemorrhagic Fever:

Name: Dengue Hemorrhagic Fever 37 12 51 3 14
Severe Dengue 41 69
Dhf 12 3
Dengue Haemorrhagic Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12206
ICD10 32 A91
MeSH 41 D019595
NCIt 46 C34683
UMLS 69 C0019100

Summaries for Dengue Hemorrhagic Fever

CDC : 3 With more than one-third of the world’s population living in areas at risk for infection, dengue virus is a leading cause of illness and death in the tropics and subtropics. As many as 400 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are not yet any vaccines to prevent infection with dengue virus and the most effective protective measures are those that avoid mosquito bites. When infected, early recognition and prompt supportive treatment can substantially lower the risk of medical complications and death.

MalaCards based summary : Dengue Hemorrhagic Fever, also known as severe dengue, is related to compartment syndrome and japanese encephalitis, and has symptoms including hemorrhagic lesions of the skin, thrombocytopenia and reduction in the fluid part of the blood. An important gene associated with Dengue Hemorrhagic Fever is CD209 (CD209 Molecule), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Histamine and Ketotifen have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and kidney, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has symptom hemorrhagic lesions of the skin, has symptom thrombocytopenia, has symptom reduction in the fluid part of the blood, and has symptom high fever.

Related Diseases for Dengue Hemorrhagic Fever

Diseases related to Dengue Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 392)
# Related Disease Score Top Affiliating Genes
1 compartment syndrome 30.5 ALB F2 TNF
2 japanese encephalitis 30.5 CD209 STAT1 TNF
3 hemophagocytic lymphohistiocytosis 30.1 CXCL8 IFNG IL10 TNF
4 myocarditis 30.1 CD40LG IL6 TNF
5 hantavirus pulmonary syndrome 30.0 CD40LG F2 F3
6 acute pancreatitis 30.0 CXCL8 IL10 IL6
7 hepatitis a 30.0 ALB F2 F3 TNF
8 dengue shock syndrome 30.0 CMA1 HLA-A HLA-DRB1 IL6 TNF
9 purpura 29.8 CD40LG F2 F3 TNF
10 hemorrhagic fever 29.8 ALB CD209 CD40LG F2 F3 HLA-DRB1
11 acute respiratory distress syndrome 29.7 CXCL8 IL6 TNF
12 typhoid fever 29.7 ALB IFNG IL6 TNF
13 gingivitis 29.7 CXCL8 IL6 TNF
14 kawasaki disease 29.5 ALB FCGR2A IL10 IL6 TNF
15 filariasis 29.5 ALB IFNG IL10 IL6 TNF
16 pneumonia 29.0 CD40LG CXCL8 IL10 IL6 TNF
17 acquired immunodeficiency syndrome 28.9 ALB CD40LG IFNG IL10 IL6 TNF
18 peritonitis 28.5 ALB CXCL8 F2 IFNG IL10 IL6
19 malaria 27.1 ALB CD40LG CXCL8 F3 FCGR2A HLA-A
20 dengue disease 12.1
21 dengue virus 11.6
22 punctate inner choroidopathy 10.6 IL10 TNF
23 tropical endomyocardial fibrosis 10.6 IL10 TNF
24 juvenile myasthenia gravis 10.6 HLA-DRB1 IL10
25 antipyrine metabolism 10.5 ALB F2
26 non-a-e hepatitis 10.5 ALB F2
27 hyperlucent lung 10.5 IFNG IL10
28 multifocal choroiditis 10.5 IL10 TNF
29 cerebral falx meningioma 10.5 F2 F3
30 postherpetic neuralgia 10.5 HLA-A HLA-DRB1
31 marburg hemorrhagic fever 10.5 CD209 F2 TNF
32 endomyocardial fibrosis 10.5 IL10 TNF
33 beryllium disease 10.5 HLA-DRB1 TNF
34 microscopic polyangiitis 10.5 HLA-DRB1 IL10 TNF
35 staphylococcal toxic shock syndrome 10.5 IFNG TNF
36 intestinal impaction 10.5 F2 F3
37 autoimmune myocarditis 10.4 IFNG TNF
38 scorpion envenomation 10.4 IL6 TNF
39 orofacial granulomatosis 10.4 IFNG IL10 TNF
40 transient hypogammaglobulinemia 10.4 IL10 TNF
41 cerebral sinovenous thrombosis 10.4 F2 F3
42 chronic beryllium disease 10.4 HLA-DRB1 IFNG TNF
43 lepromatous leprosy 10.4 IFNG IL10 TNF
44 peanut allergy 10.4 HLA-DRB1 IFNG IL10
45 acute graft versus host disease 10.4 IFNG IL10 TNF
46 ross river fever 10.4 CD40LG IL10
47 intracranial hypertension 10.4 F2 F3 TNF
48 tick-borne encephalitis 10.4 ALB CD209 IL10
49 nontuberculous mycobacterial lung disease 10.4 HLA-A HLA-DRB1 TNF
50 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF

Graphical network of the top 20 diseases related to Dengue Hemorrhagic Fever:



Diseases related to Dengue Hemorrhagic Fever

Symptoms & Phenotypes for Dengue Hemorrhagic Fever

Symptoms:

12
  • hemorrhagic lesions of the skin
  • thrombocytopenia
  • reduction in the fluid part of the blood
  • high fever

GenomeRNAi Phenotypes related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CD40LG CXCL8 F2 IL10 STAT1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CD40LG CXCL8 F2 IL10 STAT1 TNF

MGI Mouse Phenotypes related to Dengue Hemorrhagic Fever:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.14 CD40LG CMA1 F2 F3 FCGR2A IFNG
2 immune system MP:0005387 10.11 CD40LG CMA1 F2 F3 FCGR2A IFNG
3 mortality/aging MP:0010768 10 ALB CD40LG F2 F3 FCGR2A IFNG
4 digestive/alimentary MP:0005381 9.98 ALB F2 IFNG IL10 IL6 STAT1
5 integument MP:0010771 9.92 CD40LG F2 F3 IFNG IL10 IL6
6 muscle MP:0005369 9.7 ALB F3 IFNG IL10 IL6 STAT1
7 neoplasm MP:0002006 9.5 IL6 STAT1 TNF ALB F3 IFNG
8 skeleton MP:0005390 9.23 IL6 STAT1 TNF IFNG IL10 CD40LG

Drugs & Therapeutics for Dengue Hemorrhagic Fever

Drugs for Dengue Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
2
Ketotifen Approved Phase 4 34580-13-7, 34580-14-8 3827
3 Anti-Allergic Agents Phase 4
4 Antipruritics Phase 4
5 Dermatologic Agents Phase 4
6 Histamine Antagonists Phase 4
7 Histamine H1 Antagonists Phase 4
8
Histamine Phosphate Phase 4 51-74-1 65513
9 Neurotransmitter Agents Phase 4
10
Ivermectin Approved, Investigational, Vet_approved Phase 2, Phase 3 70288-86-7 46936176 6474909
11 Pharmaceutical Solutions Phase 3,Phase 2
12 Anti-Infective Agents Phase 2, Phase 3
13 Antiparasitic Agents Phase 2, Phase 3
14 Vaccines Phase 3,Phase 2,Phase 1
15 Heptavalent Pneumococcal Conjugate Vaccine Phase 3,Phase 2
16
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 657311 5754
17
Ribavirin Approved Phase 2 36791-04-5 37542
18
Neomycin Approved, Vet_approved Phase 1, Phase 2 1404-04-2 8378
19 Antimetabolites Phase 2
20 Antiviral Agents Phase 2
21 Cortisol succinate Phase 2
22 Hydrocortisone 17-butyrate 21-propionate Phase 2
23 Hydrocortisone acetate Phase 2
24 Coagulants Phase 2
25 Hemostatics Phase 2
26 Antibodies Phase 1, Phase 2
27 Immunoglobulins Phase 1, Phase 2
28
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
29
Aluminum sulfate Approved Phase 1 10043-01-3
30 Adjuvants, Immunologic Phase 1
31 Antacids Phase 1
32 Anti-Ulcer Agents Phase 1
33 Gastrointestinal Agents Phase 1
34 gamma-Globulins
35 Immunoglobulins, Intravenous
36 Rho(D) Immune Globulin
37 Endothelial Growth Factors
38 Mitogens

Interventional clinical trials:

(show top 50) (show all 100)

# Name Status NCT ID Phase Drugs
1 Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Unknown status NCT02673840 Phase 4 Ketotifen;Placebo
2 Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS) Unknown status NCT00966628 Phase 3 Hypertonic sodium lactate;Ringer's lactate
3 Efficacy and Safety of Ivermectin Against Dengue Infection Unknown status NCT02045069 Phase 2, Phase 3 2 days Ivermectin;3 days Ivermectin;Placebo
4 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia Unknown status NCT01373281 Phase 3
5 Study of a Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 11 Years in Malaysia Completed NCT01254422 Phase 3
6 Study of a Tetravalent Dengue Vaccine in Healthy Adults in Australia Completed NCT01134263 Phase 3
7 Study of a Booster Injection of Pentaxim™ Vaccine Administered With Dengue Vaccine in Healthy Toddlers Completed NCT01411241 Phase 3
8 Study of Yellow Fever Vaccine Administered With Tetravalent Dengue Vaccine in Healthy Toddlers Completed NCT01436396 Phase 3
9 Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects Active, not recruiting NCT02992418 Phase 3
10 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Gardasil® Active, not recruiting NCT02993757 Phase 3
11 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Cervarix® Active, not recruiting NCT02979535 Phase 3
12 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America Active, not recruiting NCT01374516 Phase 3
13 Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children Active, not recruiting NCT02747927 Phase 3 TDV Placebo
14 Lot-to-lot Consistency of 3 Lots of Tetravalent Dengue Vaccine (TDV) in Non-endemic Country(Ies) for Dengue Not yet recruiting NCT03423173 Phase 3
15 Chinese and Western Medicine Treatment of Fever Associated With Bleeding Symptoms Unknown status NCT01973855 Phase 2 Western Medicine;TCM and Western Medicine
16 Activated Recombinant Human Factor VII in Patients With Dengue Haemorrhagic Fever Completed NCT01601613 Phase 2 activated recombinant human factor VII;placebo
17 Celgosivir as a Treatment Against Dengue Completed NCT01619969 Phase 1, Phase 2 celgosivir;placebo
18 A Study of Dengue Vaccine in Healthy Toddlers Aged 12 to 15 Months in the Philippines Completed NCT01064141 Phase 2
19 Study of CYD Dengue Vaccine in Healthy Children and Adolescents in South America Completed NCT01187433 Phase 2
20 Immunogenicity and Safety of Three Formulations of Dengue Vaccines in Healthy Adults Aged 18 to 45 Years in the US Completed NCT00617344 Phase 2
21 Study of Febrile Illness for Dengue-Endemic Areas in Latin America Completed NCT01293331 Phase 1, Phase 2
22 Study of a Tetravalent Dengue Vaccine in Healthy Adult Subjects Aged 18 to 45 Years in India Completed NCT01550289 Phase 2
23 Immunologic Mechanisms of Immune Interference and/or Cross-Neutralizing Immunity After CYD Tetravalent Dengue Vaccine Completed NCT01943825 Phase 2
24 Safety and Immunogenicity of Formulations of Dengue Vaccines in Healthy Flavivirus-Naïve Adults Completed NCT00740155 Phase 2
25 Study of ChimeriVax™ Dengue Tetravalent Vaccine in Adult Subjects Completed NCT00730288 Phase 2
26 Study of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Subjects in Singapore Completed NCT00880893 Phase 2
27 Immunogenicity and Safety of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Children and Adolescents in Latin America Completed NCT00993447 Phase 2
28 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
29 Efficacy and Safety of Dengue Vaccine in Healthy Children Completed NCT00842530 Phase 2
30 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Peruvian Children Aged 2 to 11 Years Completed NCT00788151 Phase 2
31 Immune Response to Different Schedules of a Tetravalent Dengue Vaccine Given With or Without Yellow Fever Vaccine Completed NCT01488890 Phase 2
32 A Study of Two Doses of WRAIR Dengue Vaccine Administered Six Months Apart to Healthy Adults and Children Completed NCT00468858 Phase 2
33 Safety and Immunogenicity With Two Different Serotype 2 Potencies of Tetravalent Dengue Vaccine (TDV) in Adults in Singapore Completed NCT02425098 Phase 2
34 Safety and Immunogenicity of Three Formulations of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) Completed NCT02193087 Phase 2 TDV Liquid Formulation 1;TDV Liquid Formulation 2;TDV IDT Lyophilized;Placebo
35 A Phase I/II Trial of a Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naïve Children Completed NCT00384670 Phase 1, Phase 2
36 A Phase I/II Trial of Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naive Infants Completed NCT00322049 Phase 1, Phase 2
37 VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents Recruiting NCT03110770 Phase 2
38 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Booster Injection in Subjects Who Previously Completed a 3-dose Schedule Active, not recruiting NCT02824198 Phase 2
39 Immunogenicity and Safety of 3-Dose and Booster Dose of Tetravalent Dengue Vaccine in Healthy Subjects 9 to 50 Years of Age Active, not recruiting NCT02628444 Phase 2
40 Study of a Booster Dose of a Tetravalent Dengue Vaccine in Subjects Who Previously Completed the 3-dose Schedule Active, not recruiting NCT02623725 Phase 2
41 Safety and Immunogenicity of Different Schedules of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) in Healthy Participants Active, not recruiting NCT02302066 Phase 2 TDV Placebo
42 Celgosivir or Modipafant as Treatment for Adult Participants With Uncomplicated Dengue Fever in Singapore Not yet recruiting NCT02569827 Phase 1, Phase 2 Celgosivir;Modipafant 50mg;Placebo;Modipafant 100mg
43 Pharmacokinetics and Pharmacodynamics of Ivermectin in Pediatric Dengue Patients Not yet recruiting NCT03432442 Phase 2 Ivermectin
44 Safety and Immunogenicity of a Tetravalent Dengue Vaccine in HIV-Positive Adults Not yet recruiting NCT02741128 Phase 2
45 Safety of and Immune Response to Two Different Dengue Virus Vaccines in Individuals Previously Immunized Against Dengue Virus Completed NCT00458120 Phase 1
46 A Study of Balapiravir in Patients With Dengue Virus Infection Completed NCT01096576 Phase 1 balapiravir [RO4588161];placebo
47 Safety and Immunogenicity Study to Assess TDV, a Live Attenuated Tetravalent Vaccine for Prevention of Dengue Fever Completed NCT01224639 Phase 1
48 Safety of and Immune Response to DEN4 Vaccine Component Candidate for Dengue Virus Completed NCT00919178 Phase 1
49 Safety of and Immune Response to a Dengue Virus Vaccine (rDEN3delta30/31‐7164) in Healthy Adults Completed NCT00831012 Phase 1
50 Safety Study of a Vaccine (DENV-1 PIV) to Prevent Dengue Disease Completed NCT01502735 Phase 1

Search NIH Clinical Center for Dengue Hemorrhagic Fever

Cochrane evidence based reviews: severe dengue

Genetic Tests for Dengue Hemorrhagic Fever

Anatomical Context for Dengue Hemorrhagic Fever

MalaCards organs/tissues related to Dengue Hemorrhagic Fever:

38
Skin, Endothelial, Kidney, Testes, Monocytes, Pituitary, Thyroid

Publications for Dengue Hemorrhagic Fever

Articles related to Dengue Hemorrhagic Fever:

(show top 50) (show all 511)
# Title Authors Year
1
Dengue Hemorrhagic Fever Virus in Saudi Arabia: A Review. ( 29319426 )
2018
2
Dengue hemorrhagic fever complicated with transient diabetic ketoacidosis: a case report. ( 29078811 )
2017
3
A Correlation of the Platelet Count with D-Dimer Levels as an Indicator for Component Therapy in Children with Dengue Hemorrhagic Fever. ( 28596655 )
2017
4
Corrigendum to "Does Comorbidity Increase the Risk of Dengue Hemorrhagic Fever and Dengue Shock Syndrome?" ( 29360109 )
2017
5
Serum cytokine/chemokine profiles in patients with dengue fever (DF) and dengue hemorrhagic fever (FHD) by using protein array. ( 28242509 )
2017
6
Management dilemmas in a rare case of pituitary apoplexy in the setting of dengue hemorrhagic fever. ( 28217383 )
2017
7
Vitamin D serostatus and dengue fever progression to dengue hemorrhagic fever/dengue shock syndrome. ( 28903788 )
2017
8
Spontaneous rectus sheath hematomas in dengue hemorrhagic fever: A case report. ( 28856103 )
2017
9
Dengue hemorrhagic fever complicated with acute liver failure: a case report. ( 29216924 )
2017
10
Dengue Hemorrhagic Fever in the Northwest of Mexico: A Two-Decade Analysis. ( 28613285 )
2017
11
A pediatric case of imported dengue hemorrhagic fever in Japan. ( 29264075 )
2017
12
IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever. ( 28827898 )
2017
13
Association of Single-Nucleotide Polymorphisms in Immune-Related Genes with Development of Dengue Hemorrhagic Fever in a Mexican Population. ( 29130827 )
2017
14
Dengue Hemorrhagic Fever: ARare Cause of Acute Liver Failure. ( 28903847 )
2017
15
Differences in Mortality and Clinical Manifestations of Dengue Hemorrhagic Fever in Taiwan in Different Years: A Comparison for Cases in 2014 and 2015 Epidemics. ( 28722609 )
2017
16
Chymase Level Is a Predictive Biomarker of Dengue Hemorrhagic Fever in Pediatric and Adult Patients. ( 28968807 )
2017
17
Dengue Hemorrhagic Fever: A State-of-the-Art Review Focused in Pulmonary Involvement. ( 28612239 )
2017
18
Dengue hemorrhagic fever and the kidney. ( 26699788 )
2016
19
Interleukin-10 as a Marker of Disease Progression in Dengue Hemorrhagic Fever. ( 26975948 )
2016
20
Life-Threatening Thrombo-embolic Events in a Case of Dengue Hemorrhagic Fever. ( 27762119 )
2016
21
Human kidney damage in fatal dengue hemorrhagic fever results of glomeruli injury mainly induced by IL17. ( 26741825 )
2016
22
Characterization of dengue virus infections in a sample of patients suggests unique clinical, immunological, and virological profiles that impact on the diagnosis of dengue and dengue hemorrhagic fever. ( 26990973 )
2016
23
Acute pancreatitis complicating dengue hemorrhagic fever. ( 27812667 )
2016
24
A favorable outcome from dengue hemorrhagic fever: Teaching Hospital Kandy, Sri Lanka, May 2016. ( 27652805 )
2016
25
Management of severe dengue hemorrhagic fever and bleeding complications in a primigravidaA patient: a case report. ( 27998318 )
2016
26
Immature Platelet Fraction, A Simple and Useful Novel Marker in Dengue Hemorrhagic Fever. ( 26897161 )
2016
27
Association of BAK1 single nucleotide polymorphism with a risk for dengue hemorrhagic fever. ( 27401010 )
2016
28
Complete Heart Block in Association with Dengue Hemorrhagic Fever. ( 27826348 )
2016
29
A favorable outcome from dengue hemorrhagic fever: Teaching Hospital Kandy, Sri Lanka, May 2016. ( 28156903 )
2016
30
Effectiveness of Recombinant Activated Factor VII (rFVII a) for Controlling Intractable Postpartum Bleeding in a case of Dengue Hemorrhagic Fever. ( 27298530 )
2016
31
Characteristics and Risk Factors for Fatality in Patients with Dengue Hemorrhagic Fever, Taiwan, 2014. ( 27273649 )
2016
32
Caveolae-mediated albumin transcytosis is enhanced in dengue-infected human endothelial cells: A model of vascular leakage in dengue hemorrhagic fever. ( 27546060 )
2016
33
Progress towards understanding the pathogenesis of dengue hemorrhagic fever. ( 27853992 )
2016
34
Dengue Hemorrhagic Fever in a Child With Early-Onset Fistulizing Crohn Disease Under Infliximab and Azathioprine Treatment. ( 26709910 )
2016
35
50 Years Ago in TheJournal ofPediatrics: Shock Associated with Dengue Infection: I. Clinical and Physiological Manifestations of Dengue Hemorrhagic Fever in Thailand, 1964. ( 26922761 )
2016
36
Hemophagocytic lymphohistiocytosis following dengue hemorrhagic fever in Hb H/Hb Constant Spring patient. ( 26011764 )
2015
37
Hemophagocytic Lymphohistiocytosis Syndrome in Dengue Hemorrhagic Fever: Correspondence. ( 25589194 )
2015
38
Arterial hypertension and skin allergy are risk factors for progression from dengue to dengue hemorrhagic fever: a case control study. ( 25996882 )
2015
39
Clinico-laboratory spectrum of dengue viral infection and risk factors associated with dengue hemorrhagic fever: a retrospective study. ( 26423145 )
2015
40
Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever. ( 26175069 )
2015
41
Dengue Hemorrhagic Fever at 60 Years: Early Evolution of Concepts of Causation and Treatment. ( 26085471 )
2015
42
Vascular leakage in dengue hemorrhagic Fever is associated with dengue infected monocytes, monocyte activation/exhaustion, and cytokines production. ( 25722892 )
2015
43
Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines. ( 25797204 )
2015
44
Frosted Branch Angiitis in a Patient Coinfected With Dengue Hemorrhagic Fever and Malaria. ( 26067694 )
2015
45
Association of combinations of interleukin-10 and pro-inflammatory cytokine gene polymorphisms with dengue hemorrhagic fever. ( 25890879 )
2015
46
Morbidity Rate Prediction of Dengue Hemorrhagic Fever (DHF) Using the Support Vector Machine and the Aedes aegypti Infection Rate in Similar Climates and Geographical Areas. ( 25961289 )
2015
47
Association Between Increased Vascular Nitric Oxide Bioavailability and Progression to Dengue Hemorrhagic Fever in Adults. ( 25732810 )
2015
48
Dengue Hemorrhagic Fever in a Japanese Traveler with Pre-existing Japanese Encephalitis Virus Antibody. ( 26060418 )
2015
49
Dengue hemorrhagic fever with discolored leg syndrome in a neonate: correspondence. ( 25416091 )
2015
50
Dengue Hemorrhagic Fever Complicated by Intercostal Artery Hemorrhage. ( 26522190 )
2015

Variations for Dengue Hemorrhagic Fever

Expression for Dengue Hemorrhagic Fever

LifeMap Discovery
Genes differentially expressed in tissues of Dengue Hemorrhagic Fever patients vs. healthy controls: 35 (show top 50) (show all 120)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 CD38 CD38 molecule Blood + 4.80 0.000
2 IFI27 interferon, alpha-inducible protein 27 Blood + 4.71 0.000
3 RRM2 ribonucleotide reductase M2 Blood + 4.63 0.000
4 IGHM immunoglobulin heavy constant mu Blood + 4.61 0.000
5 BIRC5 baculoviral IAP repeat containing 5 Blood + 4.47 0.000
6 CAV1 caveolin 1, caveolae protein, 22kDa Blood + 4.41 0.000
7 DLGAP5 discs, large (Drosophila) homolog-associated protein 5 Blood + 4.31 0.000
8 XIST X inactive specific transcript (non-protein coding) Blood - 4.31 0.023
9 CEP55 centrosomal protein 55kDa Blood + 4.28 0.000
10 BUB1 BUB1 mitotic checkpoint serine/threonine kinase Blood + 4.21 0.000
11 SHCBP1 SHC SH2-domain binding protein 1 Blood + 4.13 0.000
12 PBK PDZ binding kinase Blood + 4.13 0.000
13 IGKV3-20 immunoglobulin kappa variable 3-20 Blood + 4.13 0.000
14 TYMS thymidylate synthetase Blood + 4.07 0.000
15 CDCA2 cell division cycle associated 2 Blood + 4.06 0.000
16 MKI67 marker of proliferation Ki-67 Blood + 4.00 0.000
17 CYAT1 immunoglobulin lambda light chain-like Blood + 3.98 0.000
18 MCM10 minichromosome maintenance 10 replication initiation factor Blood + 3.98 0.000
19 NOV nephroblastoma overexpressed Blood - 3.97 0.000
20 ZWINT ZW10 interacting kinetochore protein Blood + 3.96 0.000
21 CDK1 cyclin-dependent kinase 1 Blood + 3.92 0.000
22 HMMR hyaluronan-mediated motility receptor (RHAMM) Blood + 3.90 0.000
23 SDC1 syndecan 1 Blood + 3.89 0.000
24 SPC25 SPC25, NDC80 kinetochore complex component Blood + 3.84 0.000
25 NCAPG non-SMC condensin I complex, subunit G Blood + 3.84 0.000
26 TK1 thymidine kinase 1, soluble Blood + 3.82 0.000
27 CDC20 cell division cycle 20 Blood + 3.80 0.000
28 TNFRSF17 tumor necrosis factor receptor superfamily, member 17 Blood + 3.80 0.000
29 DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) Blood + 3.80 0.000
30 TOP2A topoisomerase (DNA) II alpha Blood + 3.80 0.000
31 PI3 peptidase inhibitor 3, skin-derived Blood - 3.76 0.000
32 GLDC glycine dehydrogenase (decarboxylating) Blood + 3.75 0.000
33 IGLJ3 immunoglobulin lambda joining 3 Blood + 3.75 0.000
34 SESN3 sestrin 3 Blood - 3.75 0.000
35 KIF2C kinesin family member 2C Blood + 3.74 0.000
36 CDT1 chromatin licensing and DNA replication factor 1 Blood + 3.72 0.000
37 CDKN3 cyclin-dependent kinase inhibitor 3 Blood + 3.71 0.000
38 KIAA0101 KIAA0101 Blood + 3.71 0.000
39 EIF1AY eukaryotic translation initiation factor 1A, Y-linked Blood + 3.71 0.034
40 CNTNAP3 contactin associated protein-like 3 Blood - 3.70 0.000
41 CENPA centromere protein A Blood + 3.69 0.000
42 TTK TTK protein kinase Blood + 3.67 0.000
43 ASPM abnormal spindle microtubule assembly Blood + 3.66 0.000
44 KIF11 kinesin family member 11 Blood + 3.64 0.000
45 IGL immunoglobulin lambda locus Blood + 3.64 0.000
46 CCNB2 cyclin B2 Blood + 3.61 0.000
47 BUB1B BUB1 mitotic checkpoint serine/threonine kinase B Blood + 3.60 0.000
48 CDC6 cell division cycle 6 Blood + 3.60 0.000
49 SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 Blood + 3.60 0.000
50 DUSP5 dual specificity phosphatase 5 Blood + 3.60 0.000
Search GEO for disease gene expression data for Dengue Hemorrhagic Fever.

Pathways for Dengue Hemorrhagic Fever

Pathways related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CD209 CD40LG CXCL8 FCGR2A HLA-A HLA-DRB1
2
Show member pathways
13.56 CXCL8 F2 IFNG IL10 IL6 STAT1
3
Show member pathways
13.43 CD40LG CXCL8 IL10 IL6 STAT1 STAT2
4
Show member pathways
13.33 CD40LG CXCL8 HLA-A HLA-DRB1 IFNG IL10
5
Show member pathways
13.03 CD209 CXCL8 F3 IL6 STAT1 STAT2
6 12.86 CXCL8 IFNG IL6 STAT1 STAT2
7
Show member pathways
12.72 CD40LG CXCL8 HLA-A HLA-DRB1 IFNG IL10
8
Show member pathways
12.67 CD40LG HLA-DRB1 IFNG IL10 TNF
9
Show member pathways
12.65 HLA-DRB1 IFNG IL10 IL6 STAT1 TNF
10
Show member pathways
12.64 F2 IFNG IL10 IL6 STAT1 TNF
11
Show member pathways
12.62 CXCL8 HLA-A IL6 STAT1 STAT2 TNF
12 12.61 CD40LG IFNG IL10 STAT1 STAT2 TNF
13
Show member pathways
12.6 CD209 CXCL8 HLA-A HLA-DRB1 IFNG IL6
14
Show member pathways
12.58 HLA-A HLA-DRB1 IFNG STAT1 STAT2
15
Show member pathways
12.58 CXCL8 IFNG IL10 IL6 STAT1 TNF
16
Show member pathways
12.49 CD40LG IFNG IL10 IL6 TNF
17 12.45 HLA-A HLA-DRB1 IL6 TNF
18
Show member pathways
12.43 IFNG IL10 IL6 STAT1 STAT2
19
Show member pathways
12.4 ALB F2 IFNG IL6 TNF
20
Show member pathways
12.37 CXCL8 IFNG IL6 TNF
21
Show member pathways
12.34 IFNG IL6 STAT1 STAT2
22 12.34 HLA-A HLA-DRB1 IFNG IL10
23
Show member pathways
12.33 CXCL8 IFNG IL6 STAT1 TNF
24
Show member pathways
12.26 IFNG STAT1 STAT2 TNF
25
Show member pathways
12.25 CXCL8 IFNG IL6 STAT1 TNF
26 12.23 IFNG IL6 STAT1 TNF
27 12.22 CXCL8 IL10 IL6 TNF
28
Show member pathways
12.22 CD40LG FCGR2A HLA-DRB1 IFNG IL10 STAT1
29 12.19 CD209 FCGR2A HLA-A HLA-DRB1
30 12.12 IL6 STAT1 STAT2 TNF
31 12.11 CXCL8 STAT1 STAT2 TNF
32 12.1 FCGR2A IFNG STAT1 STAT2 TNF
33 12.06 CXCL8 FCGR2A IFNG IL6 TNF
34
Show member pathways
12.04 HLA-A HLA-DRB1 IFNG STAT1
35 12.03 CXCL8 IL10 IL6 STAT1 TNF
36 12 CD209 FCGR2A IFNG IL10 IL6 TNF
37 11.95 CXCL8 IFNG IL6
38 11.95 CXCL8 F3 IL6 STAT1 TNF
39 11.93 CXCL8 IFNG IL10 IL6 TNF
40
Show member pathways
11.93 IFNG IL10 IL6 STAT1 STAT2 TNF
41 11.91 HLA-DRB1 IL6 TNF
42 11.9 CD40LG CXCL8 TNF
43 11.9 IFNG IL10 IL6 STAT1 STAT2
44 11.89 CXCL8 IFNG IL6 STAT1
45 11.89 CXCL8 HLA-DRB1 IFNG IL6 TNF
46
Show member pathways
11.88 IFNG IL6 STAT1
47 11.86 CXCL8 IFNG IL6
48
Show member pathways
11.85 CD40LG CXCL8 IFNG TNF
49 11.84 CXCL8 IL10 IL6 TNF
50 11.82 IFNG IL10 TNF

GO Terms for Dengue Hemorrhagic Fever

Cellular components related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 CD209 CD40LG F3 HLA-A HLA-DRB1 TNF
2 extracellular space GO:0005615 9.61 ALB CD40LG CXCL8 F2 F3 IFNG
3 external side of plasma membrane GO:0009897 9.55 CD209 CD40LG F2 HLA-DRB1 TNF
4 extracellular region GO:0005576 9.36 ALB CD209 CD40LG CMA1 CXCL8 F2

Biological processes related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.95 CD209 HLA-A HLA-DRB1 STAT1 STAT2
2 inflammatory response GO:0006954 9.85 CD40LG CXCL8 IL10 IL6 TNF
3 defense response to virus GO:0051607 9.81 IFNG IL6 STAT1 STAT2
4 type I interferon signaling pathway GO:0060337 9.77 HLA-A STAT1 STAT2
5 response to glucocorticoid GO:0051384 9.76 IL10 IL6 TNF
6 positive regulation of T cell proliferation GO:0042102 9.75 CD209 CD40LG IL6
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.74 IL6 STAT1 TNF
8 humoral immune response GO:0006959 9.73 IFNG IL6 TNF
9 interleukin-12-mediated signaling pathway GO:0035722 9.71 IFNG IL10 STAT1
10 negative regulation of growth of symbiont in host GO:0044130 9.63 IL10 TNF
11 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.62 IFNG STAT1
12 response to molecule of bacterial origin GO:0002237 9.62 CXCL8 IL10
13 cellular response to lipopolysaccharide GO:0071222 9.62 CXCL8 IL10 IL6 TNF
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
15 negative regulation of lipid storage GO:0010888 9.61 IL6 TNF
16 antigen processing and presentation GO:0019882 9.61 CD209 HLA-A HLA-DRB1
17 endothelial cell apoptotic process GO:0072577 9.6 IL10 TNF
18 negative regulation of cytokine secretion involved in immune response GO:0002740 9.52 IL10 TNF
19 regulation of receptor activity GO:0010469 9.5 CD40LG CXCL8 F2 IFNG IL10 IL6
20 positive regulation of STAT protein import into nucleus GO:2000366 9.49 F2 IL6
21 regulation of immunoglobulin secretion GO:0051023 9.48 CD40LG TNF
22 interferon-gamma-mediated signaling pathway GO:0060333 9.46 HLA-A HLA-DRB1 IFNG STAT1
23 receptor biosynthetic process GO:0032800 9.4 IL10 TNF
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG TNF
25 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 IFNG TNF
26 immune response GO:0006955 9.23 CD40LG CXCL8 HLA-A HLA-DRB1 IFNG IL10

Molecular functions related to Dengue Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG STAT1 TNF
2 peptide antigen binding GO:0042605 9.13 CD209 HLA-A HLA-DRB1
3 cytokine activity GO:0005125 9.1 CD40LG CXCL8 IFNG IL10 IL6 TNF

Sources for Dengue Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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