Aliases & Classifications for Dengue Shock Syndrome

MalaCards integrated aliases for Dengue Shock Syndrome:

Name: Dengue Shock Syndrome 12 51 14 69
Dss 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050125
UMLS 69 C0376300

Summaries for Dengue Shock Syndrome

Disease Ontology : 12 A dengue disease that involves the most severe form of dengue fever, has material basis in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has symptom easy bruising, has symptom blood spots, has symptom bleeding gums, and has symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth.

MalaCards based summary : Dengue Shock Syndrome, also known as dss, is related to hemorrhagic fever and acute respiratory distress syndrome, and has symptoms including easy bruising, blood spots and bleeding gums. An important gene associated with Dengue Shock Syndrome is THBD (Thrombomodulin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-Like receptor Signaling Pathways. The drugs Histamine and Ketotifen have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and heart.

Related Diseases for Dengue Shock Syndrome

Diseases related to Dengue Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic fever 30.6 HLA-DRB1 IL6 TNF
2 acute respiratory distress syndrome 29.7 IL1B IL6 TNF
3 dengue hemorrhagic fever 29.6 CMA1 HLA-A HLA-DRB1 IL6 TNF
4 peritonitis 28.9 CCL2 IL1B IL6 TNF
5 malaria 26.8 CCL2 HLA-A HLA-DRB1 IL1B IL1RN IL6
6 dengue disease 12.1
7 hypertrophic neuropathy of dejerine-sottas 11.5
8 dengue virus 11.5
9 polyposis, gastric 10.4 IL1B TNF
10 systemic onset juvenile idiopathic arthritis 10.4 IL1B TNF
11 gastric cancer, hereditary diffuse 10.4 IL1B IL1RN
12 staphylococcal toxic shock syndrome 10.4 IL1B TNF
13 kashin-beck disease 10.4 IL1B TNF
14 cutaneous mastocytosis 10.4 CMA1 TPSAB1
15 recurrent corneal erosion 10.4 IL1B IL6
16 schnitzler syndrome 10.4 IL1B IL1RN
17 bagassosis 10.4 IL1B IL6
18 periodontitis, chronic 10.3 IL1B IL6
19 scleral disease 10.3 IL1RN TNF
20 cryopyrin-associated periodic syndrome 10.3 IL1RN IL6
21 burns 10.3 IL1B TNF
22 scorpion envenomation 10.3 IL6 TNF
23 acute cholangitis 10.3 IL1RN IL6
24 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
25 critical limb ischemia 10.3 IL6 TNF
26 uremic pruritus 10.3 IL1B IL6
27 streptococcal toxic-shock syndrome 10.3 IL6 TNF
28 null-cell leukemia 10.3 IL6 TNF
29 funisitis 10.3 IL1B IL6
30 haemophilus influenzae 10.2 IL1B TNF
31 euthyroid sick syndrome 10.2 IL1B IL6
32 beryllium disease 10.2 HLA-DRB1 TNF
33 microscopic polyangiitis 10.2 HLA-DRB1 TNF
34 retinitis pigmentosa 55 10.2 IL6 TNF
35 meningococcemia 10.2 IL1B IL1RN THBD
36 chronic beryllium disease 10.2 HLA-DRB1 TNF
37 vulvar vestibulitis syndrome 10.2 IL1B IL1RN TNF
38 retinitis pigmentosa 60 10.2 IL1B TNF
39 cerebral artery occlusion 10.2 IL1B IL1RN TNF
40 autoimmune pancreatitis 10.2 HLA-DRB1 TNF
41 aseptic meningitis 10.2 IL1B IL1RN TNF
42 ascaris lumbricoides infection 10.2 IL1B IL6
43 peptic ulcer disease 10.2 IL1B IL1RN TNF
44 glossitis 10.2 IL6 TNF
45 atrophic gastritis 10.2 IL1B IL1RN TNF
46 duodenal ulcer 10.2 IL1B IL1RN TNF
47 familial mediterranean fever 10.2 IL1B IL1RN TNF
48 hydrarthrosis 10.2 IL1B IL1RN IL6
49 anca-associated vasculitis 10.1 HLA-DRB1 IL6
50 end stage renal failure 10.1 IL6 PLCE1 TNF

Graphical network of the top 20 diseases related to Dengue Shock Syndrome:



Diseases related to Dengue Shock Syndrome

Symptoms & Phenotypes for Dengue Shock Syndrome

Symptoms:

12
  • easy bruising
  • blood spots
  • bleeding gums
  • nosebleeds

Drugs & Therapeutics for Dengue Shock Syndrome

Drugs for Dengue Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
2
Ketotifen Approved Phase 4 34580-13-7, 34580-14-8 3827
3 Anti-Allergic Agents Phase 4
4 Antipruritics Phase 4
5 Dermatologic Agents Phase 4
6 Histamine Antagonists Phase 4
7 Histamine H1 Antagonists Phase 4
8
Histamine Phosphate Phase 4 51-74-1 65513
9 Neurotransmitter Agents Phase 4
10
Ivermectin Approved, Investigational, Vet_approved Phase 2, Phase 3 70288-86-7 46936176 6474909
11 Pharmaceutical Solutions Phase 3,Phase 2
12 Anti-Infective Agents Phase 2, Phase 3
13 Antiparasitic Agents Phase 2, Phase 3
14 Vaccines Phase 3,Phase 2,Phase 1
15 Heptavalent Pneumococcal Conjugate Vaccine Phase 3,Phase 2
16
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 657311 5754
17
Ribavirin Approved Phase 2 36791-04-5 37542
18
Neomycin Approved, Vet_approved Phase 1, Phase 2 1404-04-2 8378
19 Antimetabolites Phase 2
20 Antiviral Agents Phase 2
21 Cortisol succinate Phase 2
22 Hydrocortisone 17-butyrate 21-propionate Phase 2
23 Hydrocortisone acetate Phase 2
24 Antibodies Phase 1, Phase 2
25 Immunoglobulins Phase 1, Phase 2
26
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
27
Aluminum sulfate Approved Phase 1 10043-01-3
28 Adjuvants, Immunologic Phase 1
29 Antacids Phase 1
30 Anti-Ulcer Agents Phase 1
31 Gastrointestinal Agents Phase 1
32 gamma-Globulins
33 Immunoglobulins, Intravenous
34 Rho(D) Immune Globulin

Interventional clinical trials:

(show top 50) (show all 98)

# Name Status NCT ID Phase Drugs
1 Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Unknown status NCT02673840 Phase 4 Ketotifen;Placebo
2 Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS) Unknown status NCT00966628 Phase 3 Hypertonic sodium lactate;Ringer's lactate
3 Efficacy and Safety of Ivermectin Against Dengue Infection Unknown status NCT02045069 Phase 2, Phase 3 2 days Ivermectin;3 days Ivermectin;Placebo
4 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia Unknown status NCT01373281 Phase 3
5 Study of a Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 11 Years in Malaysia Completed NCT01254422 Phase 3
6 Study of a Tetravalent Dengue Vaccine in Healthy Adults in Australia Completed NCT01134263 Phase 3
7 Study of a Booster Injection of Pentaxim™ Vaccine Administered With Dengue Vaccine in Healthy Toddlers Completed NCT01411241 Phase 3
8 Study of Yellow Fever Vaccine Administered With Tetravalent Dengue Vaccine in Healthy Toddlers Completed NCT01436396 Phase 3
9 Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects Active, not recruiting NCT02992418 Phase 3
10 Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children Active, not recruiting NCT02747927 Phase 3 TDV Placebo
11 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Gardasil® Active, not recruiting NCT02993757 Phase 3
12 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Cervarix® Active, not recruiting NCT02979535 Phase 3
13 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America Active, not recruiting NCT01374516 Phase 3
14 Lot-to-lot Consistency of 3 Lots of Tetravalent Dengue Vaccine (TDV) in Non-endemic Country(Ies) for Dengue Not yet recruiting NCT03423173 Phase 3
15 Chinese and Western Medicine Treatment of Fever Associated With Bleeding Symptoms Unknown status NCT01973855 Phase 2 Western Medicine;TCM and Western Medicine
16 Celgosivir as a Treatment Against Dengue Completed NCT01619969 Phase 1, Phase 2 celgosivir;placebo
17 Study of Febrile Illness for Dengue-Endemic Areas in Latin America Completed NCT01293331 Phase 1, Phase 2
18 A Study of Dengue Vaccine in Healthy Toddlers Aged 12 to 15 Months in the Philippines Completed NCT01064141 Phase 2
19 Immunogenicity and Safety of Three Formulations of Dengue Vaccines in Healthy Adults Aged 18 to 45 Years in the US Completed NCT00617344 Phase 2
20 Study of CYD Dengue Vaccine in Healthy Children and Adolescents in South America Completed NCT01187433 Phase 2
21 Safety and Immunogenicity With Two Different Serotype 2 Potencies of Tetravalent Dengue Vaccine (TDV) in Adults in Singapore Completed NCT02425098 Phase 2
22 Safety and Immunogenicity of Three Formulations of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) Completed NCT02193087 Phase 2 TDV Liquid Formulation 1;TDV Liquid Formulation 2;TDV IDT Lyophilized;Placebo
23 A Phase I/II Trial of a Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naïve Children Completed NCT00384670 Phase 1, Phase 2
24 Study of a Tetravalent Dengue Vaccine in Healthy Adult Subjects Aged 18 to 45 Years in India Completed NCT01550289 Phase 2
25 A Study of Two Doses of WRAIR Dengue Vaccine Administered Six Months Apart to Healthy Adults and Children Completed NCT00468858 Phase 2
26 Immunologic Mechanisms of Immune Interference and/or Cross-Neutralizing Immunity After CYD Tetravalent Dengue Vaccine Completed NCT01943825 Phase 2
27 Safety and Immunogenicity of Formulations of Dengue Vaccines in Healthy Flavivirus-Naïve Adults Completed NCT00740155 Phase 2
28 Study of ChimeriVax™ Dengue Tetravalent Vaccine in Adult Subjects Completed NCT00730288 Phase 2
29 Immune Response to Different Schedules of a Tetravalent Dengue Vaccine Given With or Without Yellow Fever Vaccine Completed NCT01488890 Phase 2
30 Study of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Subjects in Singapore Completed NCT00880893 Phase 2
31 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
32 Efficacy and Safety of Dengue Vaccine in Healthy Children Completed NCT00842530 Phase 2
33 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Peruvian Children Aged 2 to 11 Years Completed NCT00788151 Phase 2
34 Immunogenicity and Safety of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Children and Adolescents in Latin America Completed NCT00993447 Phase 2
35 A Phase I/II Trial of Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naive Infants Completed NCT00322049 Phase 1, Phase 2
36 VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents Recruiting NCT03110770 Phase 2
37 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Booster Injection in Subjects Who Previously Completed a 3-dose Schedule Active, not recruiting NCT02824198 Phase 2
38 Immunogenicity and Safety of 3-Dose and Booster Dose of Tetravalent Dengue Vaccine in Healthy Subjects 9 to 50 Years of Age Active, not recruiting NCT02628444 Phase 2
39 Study of a Booster Dose of a Tetravalent Dengue Vaccine in Subjects Who Previously Completed the 3-dose Schedule Active, not recruiting NCT02623725 Phase 2
40 Safety and Immunogenicity of Different Schedules of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) in Healthy Participants Active, not recruiting NCT02302066 Phase 2 TDV Placebo
41 Celgosivir or Modipafant as Treatment for Adult Participants With Uncomplicated Dengue Fever in Singapore Not yet recruiting NCT02569827 Phase 1, Phase 2 Celgosivir;Modipafant 50mg;Placebo;Modipafant 100mg
42 Safety and Immunogenicity of a Tetravalent Dengue Vaccine in HIV-Positive Adults Not yet recruiting NCT02741128 Phase 2
43 Pharmacokinetics and Pharmacodynamics of Ivermectin in Pediatric Dengue Patients Not yet recruiting NCT03432442 Phase 2 Ivermectin
44 A Study of Balapiravir in Patients With Dengue Virus Infection Completed NCT01096576 Phase 1 balapiravir [RO4588161];placebo
45 Safety and Immunogenicity Study to Assess TDV, a Live Attenuated Tetravalent Vaccine for Prevention of Dengue Fever Completed NCT01224639 Phase 1
46 Safety of and Immune Response to Two Different Dengue Virus Vaccines in Individuals Previously Immunized Against Dengue Virus Completed NCT00458120 Phase 1
47 Safety of and Immune Response to a Dengue Virus Vaccine (rDEN3delta30/31‐7164) in Healthy Adults Completed NCT00831012 Phase 1
48 Safety Study of a Vaccine (DENV-1 PIV) to Prevent Dengue Disease Completed NCT01502735 Phase 1
49 Safety of and Immune Response to a Dengue Virus Vaccine (rDEN4delta30-200,201) in Healthy Adults Completed NCT00270699 Phase 1
50 Safety of and Immune Response to a Dengue Virus Vaccine (rDEN2/4delta30[ME]) in Healthy Adults Completed NCT00094705 Phase 1

Search NIH Clinical Center for Dengue Shock Syndrome

Genetic Tests for Dengue Shock Syndrome

Anatomical Context for Dengue Shock Syndrome

MalaCards organs/tissues related to Dengue Shock Syndrome:

38
Testes, Endothelial, Heart, Liver, Bone, T Cells, Whole Blood

Publications for Dengue Shock Syndrome

Articles related to Dengue Shock Syndrome:

(show top 50) (show all 138)
# Title Authors Year
1
Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome. ( 29447178 )
2018
2
Corrigendum to "Does Comorbidity Increase the Risk of Dengue Hemorrhagic Fever and Dengue Shock Syndrome?" ( 29360109 )
2017
3
The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue. ( 28448490 )
2017
4
Dengue shock syndrome with retroperitoneal haematoma requiring repeated artery angioembolization. ( 28889142 )
2017
5
Vitamin D serostatus and dengue fever progression to dengue hemorrhagic fever/dengue shock syndrome. ( 28903788 )
2017
6
Skin dendritic cell and T cell activation associated with dengue shock syndrome. ( 29079750 )
2017
7
State-of-the-art monitoring in treatment of dengue shock syndrome: a case series. ( 27553703 )
2016
8
In silico transcriptional regulation and functional analysis of dengue shock syndrome associated SNPs in PLCE1 and MICB genes. ( 27038471 )
2016
9
Clinical Characteristics and Risk Factors of Dengue Shock Syndrome in Children. ( 27455442 )
2016
10
Dengue shock syndrome. ( 28031845 )
2016
11
Delayed subdural hematoma after recovery from dengue shock syndrome. ( 27114678 )
2016
12
Fatal invasive aspergillosis: a rare co-infection with an unexpected image presentation in a patient with dengue shock syndrome. ( 26072955 )
2015
13
Dengue haemorrhagic fever or dengue shock syndrome in children. ( 25860404 )
2015
14
Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines. ( 25797204 )
2015
15
A Prognostic Model for Development of Profound Shock among Children Presenting with Dengue Shock Syndrome. ( 25946113 )
2015
16
A replication study confirms the association of GWAS-identified SNPs at MICB and PLCE1 in Thai patients with dengue shock syndrome. ( 24884822 )
2014
17
Dengue Shock Syndrome or Dehydration? The importance of considering clinical severity when classifying patients with dengue. ( 24403543 )
2014
18
Association of IL1B -31C/T and IL1RA variable number of an 86-bp tandem repeat with dengue shock syndrome in Thailand. ( 24446526 )
2014
19
Dengue shock syndrome in an infant. ( 25073530 )
2014
20
Corticosteroids in the treatment of dengue shock syndrome. ( 24899817 )
2014
21
Early resuscitation of Dengue Shock Syndrome in children with hyperosmolar sodium-lactate: a randomized single blind clinical trial of efficacy and safety. ( 25189175 )
2014
22
Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome. ( 24305068 )
2013
23
Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. ( 23471635 )
2013
24
Differences in clinical features between children and adults with dengue hemorrhagic fever/dengue shock syndrome. ( 24437312 )
2013
25
Clinical characteristics of dengue shock syndrome in Vietnamese children: a 10-year prospective study in a single hospital. ( 24046311 )
2013
26
A patient with severe body aches without fever progressing to dengue shock syndrome. ( 24385064 )
2013
27
Serological characterization of dengue virus infections observed among dengue hemorrhagic fever/dengue shock syndrome cases in upper Myanmar. ( 23595687 )
2013
28
Factors associated with dengue shock syndrome: a systematic review and meta-analysis. ( 24086778 )
2013
29
Possible cause of liver failure in patient with dengue shock syndrome. ( 23763890 )
2013
30
A fatal combo of dengue shock syndrome with acute subdural hematoma. ( 22406795 )
2012
31
Sympathetic dysfunction as a cause for hypotension in dengue shock syndrome. ( 23075741 )
2012
32
Peritoneal dialysis in dengue shock syndrome may be detrimental. ( 22529870 )
2012
33
Repeated dengue shock syndrome and 'dengue myocarditis' responding dramatically to a single dose of methyl prednisolone. ( 22521778 )
2012
34
Splenic rupture mimicking dengue shock syndrome. ( 23025068 )
2012
35
Dengue shock syndrome with two atypical complications. ( 21842280 )
2012
36
A fatal case of bone marrow embolism of unknown cause masquerading clinically as dengue shock syndrome. ( 23455811 )
2012
37
Association of mast cell-derived VEGF and proteases in Dengue shock syndrome. ( 22363824 )
2012
38
Risk factors of dengue shock syndrome in children. ( 21367851 )
2011
39
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. ( 22001756 )
2011
40
National guidelines for diagnosis and management of dengue fever/dengue haemorrhagic fever and dengue shock syndrome. ( 21888156 )
2011
41
Infection-associated hemophagocytic syndrome among patients with dengue shock syndrome and invasive aspergillosis: a case series and review of the literature. ( 22299436 )
2011
42
Should colloid boluses be prioritized over crystalloid boluses for the management of dengue shock syndrome in the presence of ascites and pleural effusions? ( 21356095 )
2011
43
Epidemiological factors associated with dengue shock syndrome and mortality in hospitalized dengue patients in Ho Chi Minh City, Vietnam. ( 21212214 )
2011
44
Dengue shock syndrome at the emergency room of Queen Sirikit National Institute of Child Health, Bangkok, Thailand. ( 22043755 )
2011
45
Characterization of dengue shock syndrome in pediatric patients in El Salvador. ( 21490492 )
2011
46
Effect of a single dose of methyl prednisolone as rescue medication for patients who develop hypotensive dengue shock syndrome during the febrile phase: a retrospective observational study. ( 21530348 )
2011
47
Phenotypic characterization of patient dengue virus isolates in BALB/c mice differentiates dengue fever and dengue hemorrhagic fever from dengue shock syndrome. ( 21835036 )
2011
48
Phenotypic and genotypic characterization of dengue virus isolates differentiates dengue fever and dengue hemorrhagic fever from dengue shock syndrome. ( 21922323 )
2011
49
The early whole-blood transcriptional signature of dengue virus and features associated with progression to dengue shock syndrome in Vietnamese children and young adults. ( 20943967 )
2010
50
Laboratory predictors of dengue shock syndrome during the febrile stage. ( 20578515 )
2010

Variations for Dengue Shock Syndrome

Expression for Dengue Shock Syndrome

Search GEO for disease gene expression data for Dengue Shock Syndrome.

Pathways for Dengue Shock Syndrome

Pathways related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 CCL2 HLA-A HLA-DRB1 IL1B IL1RN IL6
2
Show member pathways
12.89 CCL2 IL1B IL1RN IL6 TNF
3
Show member pathways
12.78 HLA-A HLA-DRB1 IL1B IL6 TNF
4
Show member pathways
12.65 CCL2 HLA-A HLA-DRB1 IL1B IL6 TNF
5
Show member pathways
12.53 HLA-DRB1 IL1B IL6 TNF
6
Show member pathways
12.52 CCL2 IL1B IL6 TNF
7
Show member pathways
12.51 HLA-A IL6 MICB TNF
8 12.5 CCL2 IL1B IL1RN TNF
9
Show member pathways
12.46 CCL2 IL1B IL6 TNF
10 12.37 HLA-A HLA-DRB1 IL6 TNF
11
Show member pathways
12.28 CCL2 IL1B IL6 TNF
12
Show member pathways
12.27 CCL2 IL1B IL6 TNF
13 12.18 HLA-DRB1 IL1B IL6 TNF
14 12.12 IL1B IL1RN IL6 TNF
15
Show member pathways
12.06 HLA-A IL1B IL6 TNF
16 12.02 CCL2 IL1B THBD TNF
17
Show member pathways
11.92 HLA-A HLA-DRB1 IL1B
18 11.92 CCL2 IL1B IL6 TNF
19
Show member pathways
11.88 IL1B IL6 TNF
20 11.88 CCL2 IL1B IL6 TNF
21
Show member pathways
11.85 CMA1 TNF TPSAB1
22 11.84 CCL2 IL1B IL6 TNF
23 11.82 IL1B IL6 TNF
24 11.78 HLA-DRB1 IL1B IL6 TNF
25 11.72 IL1B IL6 TNF
26
Show member pathways
11.63 IL1B IL6 TNF
27 11.61 CCL2 HLA-DRB1 IL1B IL6 TNF
28 11.6 IL1B IL6 THBD TNF
29 11.55 IL1B IL6 TNF
30 11.49 CCL2 IL1B TNF
31 11.45 IL1B IL6 TNF
32 11.36 CCL2 IL1B IL6 TNF
33 11.35 CCL2 CMA1 IL1B IL6 TNF
34 11.32 IL1B IL6 TNF
35 11.31 IL1B IL6 TNF
36 11.29 CCL2 IL6 THBD
37 11.25 IL1B IL6 TNF
38 11.23 IL1B IL6 TNF
39 11.1 HLA-DRB1 IL1B IL6 TNF
40 11.1 CCL2 IL1B IL6 PLCE1 THBD TNF
41 11.05 IL1B TNF
42 11.04 IL6 TNF
43 11.04 CCL2 IL1B IL1RN IL6 TNF
44 11.03 CCL2 IL1B IL6 PLCE1 TNF
45 10.98 IL6 TNF
46 10.96 CCL2 IL1B IL6 PLCE1 TNF
47 10.84 CCL2 IL1B TNF
48 10.75 IL1B IL6

GO Terms for Dengue Shock Syndrome

Cellular components related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CCL2 IL1B IL1RN IL6 THBD TNF
2 cell surface GO:0009986 9.02 HLA-A HLA-DRB1 MICB THBD TNF

Biological processes related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.85 CCL2 IL1B IL1RN IL6 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.81 CCL2 IL1B IL6
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL1B IL6 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.79 CCL2 IL6 TNF
5 activation of MAPK activity GO:0000187 9.77 IL1B PLCE1 TNF
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.76 IL1B IL6 TNF
7 cellular response to organic cyclic compound GO:0071407 9.72 CCL2 IL1B TNF
8 response to glucocorticoid GO:0051384 9.7 IL1RN IL6 TNF
9 humoral immune response GO:0006959 9.69 CCL2 IL6 TNF
10 inflammatory response GO:0006954 9.65 CCL2 IL1B IL1RN IL6 TNF
11 positive regulation of NF-kappaB import into nucleus GO:0042346 9.64 IL1B TNF
12 positive regulation of chemokine production GO:0032722 9.62 IL6 TNF
13 negative regulation of lipid catabolic process GO:0050995 9.61 IL1B TNF
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IL1B TNF
15 positive regulation of interleukin-6 production GO:0032755 9.61 IL1B IL6 TNF
16 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.6 IL1B TNF
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
18 negative regulation of lipid storage GO:0010888 9.57 IL6 TNF
19 positive regulation of chemokine biosynthetic process GO:0045080 9.56 IL1B TNF
20 regulation of establishment of endothelial barrier GO:1903140 9.54 IL1B TNF
21 protein kinase B signaling GO:0043491 9.5 CCL2 IL1B TNF
22 fever generation GO:0001660 9.49 IL1B IL1RN
23 positive regulation of fever generation GO:0031622 9.48 IL1B TNF
24 sequestering of triglyceride GO:0030730 9.4 IL1B TNF
25 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.37 IL1RN IL6
26 immune response GO:0006955 9.17 CCL2 HLA-A HLA-DRB1 IL1B IL1RN IL6
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IL1B TNF
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.13 CCL2 IL1B TNF

Molecular functions related to Dengue Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL2 IL1B IL1RN IL6 TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B IL1RN

Sources for Dengue Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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