DDD
MCID: DNS007
MIFTS: 34

Dense Deposit Disease (DDD) malady

Summaries for Dense Deposit Disease

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Dense deposit disease (ddd) is a condition that primarily affects kidney function. signs and symptoms usually start between the ages of 5 and 15 but may also begin in adulthood. the major features of ddd are due to kidney malfunction, and often include proteinuria; hematuria; reduced amounts of urine; low levels of protein in the blood; and swelling in many areas of the body. about half of affected people develop end-stage renal disease (esrd) within 10 years after symptoms start. ddd can have genetic or non-genetic causes. it can be caused by mutations in the c3 and cfh genes; it may develop as a result of both genetic risk factors and environmental triggers; or it can result from the presence of autoantibodies that block the activity of proteins needed for the body's immune response. most cases are sporadic (occurring by chance in people with no history of the disorder in their family). last updated: 2/24/2014

MalaCards: Dense Deposit Disease, also known as membranoproliferative glomerulonephritis type ii, is related to glomerulonephritis and membranoproliferative glomerulonephritis. An important gene associated with Dense Deposit Disease is CFHR5 (complement factor H-related 5), and among its related pathways are Terminal pathway of complement and Classical Complement Pathway. The compounds formate and Intravenous Immunoglobulin have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are other and renal/urinary system.

Genetics Home Reference:21 Dense deposit disease is a condition that primarily affects kidney (renal) function. The signs and symptoms usually appear between the ages of 5 and 15, although they can also begin in adulthood.

Wikipedia:63 Membranoproliferative glomerulonephritis (\"MPGN\"), also known as mesangiocapillary glomerulonephritis,... more...

Aliases & Classifications for Dense Deposit Disease

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21Genetics Home Reference, 42NIH Rare Diseases, 22GTR
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Aliases & Descriptions:

dense deposit disease 42 21
membranoproliferative glomerulonephritis type ii 42 21
mesangiocapillary glomerulonephritis type 2 42 22
ddd 42 21
glomerulonephritis membranoproliferative type 2 42
membranoproliferative glomerulonephritis type 2 42
type ii mpgn 21
ddd/mpgnii 21
mpgnii 21


Related Diseases for Dense Deposit Disease

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17GeneCards, 18GeneDecks
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Diseases related to Dense Deposit Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis30.9CFH, VTN, C3
2membranoproliferative glomerulonephritis30.8C3, VTN, CFH
3dense deposit disease/membranoproliferative glomerulonephritis type ii30.6CFH, CFHR5
4amyloidosis30.1APOE
5age related macular degeneration30.1CFH, APOE
6nephrotic syndrome30.1VTN, APOE
7complement deficiency30.1C5, C3
8proteinuria30.1C3, VTN
9atherosclerosis30.1VTN, APOE, C3
10myocardial infarction29.9CFH, APOE
11retinitis10.5
12membranous glomerulonephritis10.4
13dowling-degos disease 110.4
14dowling-degos disease 210.4
15cfhr5-related dense deposit disease / membranoproliferative glomerulonephritis type ii10.3
16dowling-degos disease10.3
17familial partial lipodystrophy10.3
18crescentic glomerulonephritis10.3
19cfh-related dense deposit disease / membranoproliferative glomerulonephritis type ii10.3
20complement factor h deficiency10.3
21niemann-pick disease10.3
22lipodystrophy10.3
23adrenocortical carcinoma10.2
24dyschromatosis symmetrica hereditaria 110.2
25sick sinus syndrome10.2
26breast disease10.1
27pneumonia10.1
28glomerulopathy with fibronectin deposits 210.1
29immunotactoid glomerulopathy10.1
30immunotactoid or fibrillary glomerulopathy10.1
31collagen type iii glomerulopathy10.1
32non-amyloid fibrillary glomerulopathy10.1
33degenerative disc disease10.1
34adrenal carcinoma10.1
35retinal drusen10.0CFH
36thrombocytopenia10.0CFH
37hepatitis b10.0CFB
38kuhnt-junius degeneration10.0CFH
39antiphospholipid syndrome10.0CFH
40hepatitis10.0CFB
41relapsing fever10.0CFH
42hypertension10.0APOE
43endometriosis10.0VTN
44hypercholesterolemia10.0APOE
45psoriasis10.0VTN
46deficiency anemia10.0CFH
47lupus erythematosus10.0C3
48atypical hemolytic-uremic syndrome10.0CFH, CFB
49hemolytic-uremic syndrome10.0CFH, CFB
50sarcoidosis10.0VTN

Graphical network of the top 20 diseases related to Dense Deposit Disease:



Diseases related to dense deposit disease

Clinical Features for Dense Deposit Disease

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Drugs & Therapeutics for Dense Deposit Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Dense Deposit Disease

Search NIH Clinical Center for Dense Deposit Disease

Search CenterWatch for Dense Deposit Disease

Genetic Tests for Dense Deposit Disease

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22GTR
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Genetic tests related to Dense Deposit Disease:

id Genetic test Affiliating Genes
1 Mesangiocapillary Glomerulonephritis, Type Ii22

Anatomical Context for Dense Deposit Disease

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32MalaCards
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MalaCards organs/tissues related to Dense Deposit Disease:

32
Kidney

Animal Models for Dense Deposit Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dense Deposit Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.5C3, APOE, FHL1
2MP:00053678.3C3, CFH, CFB, APOE
3MP:00028737.5CFB, CFH, VTN, C5, C3
4MP:00053766.7C3, C5, VTN, CFH, CFB, APOE

Publications for Dense Deposit Disease

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Genetic Variations for Dense Deposit Disease

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Expression for genes affiliated with Dense Deposit Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dense Deposit Disease

Search GEO for disease gene expression data for Dense Deposit Disease.

Pathways for genes affiliated with Dense Deposit Disease

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53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 55SinoBiological, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Dense Deposit Disease

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Dense Deposit Disease according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1formate449.4VTN, APOE
2Intravenous Immunoglobulin119.4C3, C5
3guanidine44 11 2411.3VTN, APOE
4dermatan sulfate449.3VTN, APOE
5anaphylatoxin449.3C3, C5
6serine449.2C3, VTN
7hyaluronic acid44 2410.1APOE, CFH, VTN
8heparin44 28 11 2411.9C3, VTN, CFHR5
9polysaccharide448.7CFH, VTN, C3
10fibrinogen448.5CFH, VTN, C3
11cholesterol44 28 11 2411.3APOE, CFH, VTN, C3
12cysteine447.8C3, VTN, CFH, APOE

GO Terms for genes affiliated with Dense Deposit Disease

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16Gene Ontology
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Cellular components related to Dense Deposit Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.6C3, C5, VTN, CFH, APOE
2extracellular regionGO:0055766.5C3, APOE, CFB, CFH, CFHR5, VTN

Biological processes related to Dense Deposit Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood coagulationGO:0301959.3VTN, APOE
2complement activation, classical pathwayGO:0069589.1C3, C5
3positive regulation vascular endothelial growth factor productionGO:0105759.0C5, C3
4complement activationGO:0069568.4C3, C5, CFH, CFB
5G-protein coupled receptor signaling pathwayGO:0071868.3C3, C5, APOE
6complement activation, alternative pathwayGO:0069578.1C3, C5, CFHR5, CFH, CFB
7regulation of complement activationGO:0304497.8CFB, CFH, VTN, C5, C3
8innate immune responseGO:0450877.7CFB, CFH, VTN, C5, C3

Molecular functions related to Dense Deposit Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.1C3, C5
2heparin bindingGO:0082018.6VTN, CFH, APOE

Products for genes affiliated with Dense Deposit Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dense Deposit Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet