DDD
MCID: DNS007
MIFTS: 42

Dense Deposit Disease (DDD) malady

Rare diseases category
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Summaries for Dense Deposit Disease

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Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Dense deposit disease (ddd) is a condition that primarily affects kidney function. signs and symptoms usually start between the ages of 5 and 15 but may also begin in adulthood. the major features of ddd are due to kidney malfunction, and often include proteinuria; hematuria; reduced amounts of urine; low levels of protein in the blood; and swelling in many areas of the body. about half of affected people develop end-stage renal disease (esrd) within 10 years after symptoms start. ddd can have genetic or non-genetic causes. it can be caused by mutations in the c3 and cfh genes; it may develop as a result of both genetic risk factors and environmental triggers; or it can result from the presence of autoantibodies that block the activity of proteins needed for the body's immune response. most cases are sporadic (occurring by chance in people with no history of the disorder in their family). last updated: 2/24/2014

MalaCards: Dense Deposit Disease, also known as membranoproliferative glomerulonephritis type ii, is related to glomerulonephritis and membranoproliferative glomerulonephritis. An important gene associated with Dense Deposit Disease is CFHR5 (complement factor H-related 5), and among its related pathways are Pertussis and Phagocytosis of Microbes. The compounds anaphylatoxin and formate have been mentioned in the context of this disorder. Affiliated tissues include kidney and breast, and related mouse phenotypes are other and normal.

Genetics Home Reference:21 Dense deposit disease is a condition that primarily affects kidney (renal) function. The signs and symptoms usually appear between the ages of 5 and 15, although they can also begin in adulthood.

Wikipedia:65 Membranoproliferative glomerulonephritis (\"MPGN\"), also known as mesangiocapillary glomerulonephritis,... more...

Aliases & Classifications for Dense Deposit Disease

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21Genetics Home Reference, 43NIH Rare Diseases, 22GTR
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

dense deposit disease 43 21
membranoproliferative glomerulonephritis type ii 43 21
mesangiocapillary glomerulonephritis type 2 43 22
ddd 43 21
glomerulonephritis membranoproliferative type 2 43
membranoproliferative glomerulonephritis type 2 43
type ii mpgn 21
ddd/mpgnii 21
mpgnii 21
mpgn 2 43


Related Diseases for Dense Deposit Disease

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17GeneCards, 18GeneDecks
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Diseases related to Dense Deposit Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.0C3, CFH, VTN
2membranoproliferative glomerulonephritis30.9C3, CFH, VTN
3dense deposit disease/membranoproliferative glomerulonephritis type ii30.7CFH, CFHR5
4age related macular degeneration30.2APOE, CFH
5nephrotic syndrome30.1VTN, APOE
6atherosclerosis30.0C3, VTN, APOE
7retinitis10.5
8dowling-degos disease 110.4
9dowling-degos disease 210.4
10cfhr5-related dense deposit disease / membranoproliferative glomerulonephritis type ii10.3
11complement factor h deficiency10.3
12dowling-degos disease10.3
13familial partial lipodystrophy10.3
14niemann-pick disease10.3
15lipodystrophy10.3
16adrenocortical carcinoma10.3
17dyschromatosis symmetrica hereditaria 110.3
18crescentic glomerulonephritis10.3
19cfh-related dense deposit disease / membranoproliferative glomerulonephritis type ii10.3
20sick sinus syndrome10.2
21adrenal carcinoma10.1
22degenerative disc disease10.1
23amyloidosis10.1
24pneumonia10.1
25proteinuria10.1
26glomerulopathy with fibronectin deposits 210.1
27immunotactoid glomerulopathy10.1
28mycoplasmal pneumonia10.1
29steroid-resistant nephrotic syndrome10.1
30immunotactoid or fibrillary glomerulopathy10.1
31collagen type iii glomerulopathy10.1
32non-amyloid fibrillary glomerulopathy10.1
33retinal drusen10.1CFH
34atypical hemolytic-uremic syndrome10.1CFH, CFB
35hemolytic-uremic syndrome10.1CFH, CFB
36complement deficiency10.0C5, C3
37lupus nephritis10.0VTN, CFB
38inferior myocardial infarction10.0
39phaeochromocytoma10.0
40leydig cell tumor10.0
41malignant leydig cell tumor10.0
42myocardial infarction10.0
43intervertebral disc disease10.0
44superior vena cava syndrome10.0
45multiple sclerosis10.0APOE, VTN
46iga glomerulonephritis10.0CFH, VTN, C3
47nephritis10.0CFB, C3, VTN
48familial combined hyperlipidemia10.0C3, APOE
49rheumatoid arthritis10.0C3, VTN, CFB
50sepsis10.0C3, CFB, VTN

Graphical network of the top 20 diseases related to Dense Deposit Disease:



Diseases related to dense deposit disease

Symptoms for Dense Deposit Disease

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Drugs & Therapeutics for Dense Deposit Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Dense Deposit Disease

Search NIH Clinical Center for Dense Deposit Disease

Genetic Tests for Dense Deposit Disease

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22GTR
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Genetic tests related to Dense Deposit Disease:

id Genetic test Affiliating Genes
1 Mesangiocapillary Glomerulonephritis, Type Ii22

Anatomical Context for Dense Deposit Disease

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33MalaCards
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MalaCards organs/tissues related to Dense Deposit Disease:

33
Kidney, Breast

Animal Models for Dense Deposit Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Dense Deposit Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.7CFH, APOE, C3
2MP:00028738.2C5, C3, VTN, CFB, CFH
3MP:00053908.2C5, C3, APOE, CFB
4MP:00053678.1C3, APOE, CFB, CFH
5MP:00053877.5CFH, CFB, APOE, C3, C5
6MP:00053767.3CFH, CFB, APOE, VTN, C3, C5

Publications for Dense Deposit Disease

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52PubMed
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Articles related to Dense Deposit Disease:

(show all 20)
idTitleAuthorsYear
1
Childhood-onset dense deposit disease: a rare cause of proteinuria. (24338037)
2013
2
Dense Deposit Disease: A Rare Cause of Steroid Resistant Nephrotic Syndrome. (23783769)
2013
3
Eculizumab for dense deposit disease and C3 glomerulonephritis. (22403278)
2012
4
Experimental models of membranoproliferative glomerulonephritis, including dense deposit disease. (21252520)
2011
5
A case of dense deposit disease associated with a group A streptococcal infection without the involvement of C3NeF or complement factor H deficiency. (20221776)
2010
6
Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. (20852386)
2010
7
Anti-factor B autoantibody in dense deposit disease. (20193965)
2010
8
Membranoproliferative glomerulonephritis type II (dense deposit disease) in association with monoclonal gammopathy. (17635761)
2007
9
Dense deposit disease is not a membranoproliferative glomerulonephritis. (17396142)
2007
10
Deletion of Lys224 in regulatory domain 4 of factor H reveals a novel pathomechanism for dense deposit disease (MPGN II). (16612335)
2006
11
Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease). (16299065)
2006
12
Membranoproliferative glomerulonephritis type II (dense deposit disease): an update. (15800116)
2005
13
Crescentic glomerulonephritis and dense deposit disease in a woman with breast carcinoma on immunosuppressive chemotherapy. (15332237)
2004
14
Crescentic glomerulonephritis in childhood: acute nonproliferative glomerulitis versus dense deposit disease. (12666078)
2003
15
Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. (10783137)
2000
16
Dense Deposit Disease/Membranoproliferative Glomerulonephritis Type II (20301598)
1993
17
Porcine membranoproliferative glomerulonephritis with intramembranous dense deposits (porcine dense deposit disease). (8323737)
1993
18
Extensive complement activation in hereditary porcine membranoproliferative glomerulonephritis type II (porcine dense deposit disease). (8238252)
1993
19
Regression of membranoproliferative glomerulonephritis type II (dense deposit disease): observations in six children. (3400634)
1988
20
Mycoplasmal pneumonia associated with mesangiocapillary glomerulonephritis type II (dense deposit disease). (6516912)
1984

Variations for Dense Deposit Disease

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Expression for genes affiliated with Dense Deposit Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dense Deposit Disease

Search GEO for disease gene expression data for Dense Deposit Disease.

Pathways for genes affiliated with Dense Deposit Disease

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50PathCards, 30KEGG, 53QIAGEN, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 57SinoBiological
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Pathways related to Dense Deposit Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4C5, C3
29.3C3, VTN
3
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
8.6CFH, CFB, C3, C5
48.6CFH, CFB, C3, C5
5
Show member pathways
8.1CFH, CFB, VTN, C3, C5
6
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
8.1C5, C3, VTN, CFB, CFH

Compounds for genes affiliated with Dense Deposit Disease

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45Novoseek, 24HMDB, 11DrugBank, 3BitterDB, 51PharmGKB, 29IUPHAR
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Compounds related to Dense Deposit Disease according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1anaphylatoxin459.6C3, C5
2formate459.3VTN, APOE
3glycosaminoglycan459.3VTN, CFH
4guanidine45 24 1111.3VTN, APOE
5dermatan sulfate459.2APOE, VTN
6polysaccharide459.2C3, VTN, CFH
7fibrinogen459.2CFH, VTN, C3
8chloroquine45 3 51 29 1113.1VTN, APOE
9sodium dodecylsulfate459.1VTN, APOE
10triacylglycerol459.1C3, APOE
11hyaluronic acid45 2410.1VTN, APOE, CFH
12polyethylene glycol459.0APOE, VTN
13cholesterol45 29 24 1111.4CFH, APOE, VTN, C3
14cysteine458.4C3, VTN, APOE, CFH
15serine458.0CFH, CFB, APOE, VTN, C3
16heparin45 29 24 1110.6C3, CFH, CFHR2, CFHR5, APOE, VTN

GO Terms for genes affiliated with Dense Deposit Disease

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16Gene Ontology
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Cellular components related to Dense Deposit Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.1C5, C3, VTN, APOE
2blood microparticleGO:0725627.6CFH, CFB, APOE, VTN, C3
3extracellular spaceGO:0056157.4CFH, APOE, VTN, C3, C5
4extracellular regionGO:0055766.4C5, CFH, CFHR2, CFB, CFHR5, APOE

Biological processes related to Dense Deposit Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation vascular endothelial growth factor productionGO:0105759.5C5, C3
2positive regulation of angiogenesisGO:0457669.4C5, C3
3complement activation, classical pathwayGO:0069589.3C5, C3
4negative regulation of blood coagulationGO:0301959.2VTN, APOE
5cellular calcium ion homeostasisGO:0068748.9C5, APOE
6complement activationGO:0069568.8C5, C3, CFB, CFH
7G-protein coupled receptor signaling pathwayGO:0071868.6APOE, C3, C5
8complement activation, alternative pathwayGO:0069578.5C5, C3, CFHR5, CFB, CFH
9regulation of complement activationGO:0304498.3CFH, CFB, VTN, C3, C5
10innate immune responseGO:0450878.2CFH, CFB, VTN, C3, C5

Molecular functions related to Dense Deposit Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.4C5, C3
2heparin bindingGO:0082018.5VTN, APOE, CFH

Products for genes affiliated with Dense Deposit Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dense Deposit Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet