MCID: DNS001
MIFTS: 15

Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii malady

Categories: Genetic diseases

Aliases & Classifications for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

Aliases & Descriptions for Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii:

Name: Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii 23
Ddd/mpgnii 23 24
Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type Ii 24
Membranoproliferative Glomerulonephritis, Type Ii 69

Classifications:



Summaries for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

MalaCards based summary : Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii, also known as ddd/mpgnii, is related to cfhr5-related dense deposit disease / membranoproliferative glomerulonephritis type ii and cfh-related dense deposit disease / membranoproliferative glomerulonephritis type ii. An important gene associated with Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii is CFHR5 (Complement Factor H Related 5). The drugs Immunoglobulin A and Antigen-Antibody Complex have been mentioned in the context of this disorder.

GeneReviews: NBK1425

Related Diseases for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

Graphical network of the top 20 diseases related to Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii:



Diseases related to Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii

Symptoms & Phenotypes for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

Drugs & Therapeutics for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

Drugs for Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulin A Phase 2
2 Antigen-Antibody Complex Phase 2
3
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
4 Vaccines Phase 1
5 Angiotensin-Converting Enzyme Inhibitors Phase 1
6 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Safety Study of IgAN, LN, MN, & C3 Glomerulopathy Including Dense Deposit Disease Treated With OMS721 Recruiting NCT02682407 Phase 2
2 A Proof-of-Mechanism Study to Determine the Effect of ACH-0144471 on C3 Levels in Patients With C3G or IC-MPGN Not yet recruiting NCT03124368 Phase 2
3 Eculizumab Therapy for Dense Deposit Disease and C3 Nephropathy Unknown status NCT01221181 Phase 1
4 Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease Terminated NCT01791686 Phase 1
5 Sulodexide Treatment in Patients With Dense Deposit Disease Withdrawn NCT00583427 Phase 1
6 TP10 Use in Patients With C3 Glomerulopathy (C3G) Withdrawn NCT02302755 Phase 1

Search NIH Clinical Center for Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii

Genetic Tests for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

Genetic tests related to Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii:

id Genetic test Affiliating Genes
1 Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type Ii 24 CFHR5

Anatomical Context for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

Publications for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

Articles related to Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii:

id Title Authors Year
1
Dense Deposit Disease/Membranoproliferative Glomerulonephritis Type II ( 20301598 )
1993

Variations for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

Expression for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

Search GEO for disease gene expression data for Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii.

Pathways for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

GO Terms for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

Biological processes related to Dense Deposit Disease/membranoproliferative Glomerulonephritis Type Ii according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of complement activation GO:0030449 8.96 CFH CFHR5
2 complement activation, alternative pathway GO:0006957 8.62 CFH CFHR5

Sources for Dense Deposit Disease/membranoproliferative Glomerulonephritis...

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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