MCID: DNT012
MIFTS: 49

Dental Caries malady

Gastrointestinal diseases, Oral diseases categories
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Summaries for Dental Caries

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Wikipedia:65 Dental caries (Latin, \"rot\"), also known as tooth decay or a cavity, is an infection, bacterial in... more...

MalaCards based summary: Dental Caries, also known as dental caries extending into pulp, is related to dental fluorosis and root caries. An important gene associated with Dental Caries is DSPP (dentin sialophosphoprotein), and among its related pathways are Selected targets of C EBPalpha and Selected targets of ESR1. The compounds chlorhexidine and hypothiocyanite have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone marrow and bone.

Aliases & Classifications for Dental Caries

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Dental Caries, Aliases & Descriptions:

Name: Dental Caries 8 10 44
Dental Caries Extending into Pulp 8 62
Dental Caries of Smooth Surface 8
 
Dental Caries Pit and Fissure 8
Caries 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


External Ids:

Disease Ontology8 DOID:216
NCIt39 C52593
ICD9CM27 521.00, 521.0
MeSH34 D003731
ICD1025 K02

Related Diseases for Dental Caries

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Diseases related to Dental Caries via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1dental fluorosis32.0AMELX
2root caries31.5DSPP
3periodontitis31.5LTF, MMP8
4periodontal disease31.5LTF, CD79A
5gingivitis31.1LTF, MMP8, DSPP
6aggressive periodontitis30.7LTF, MMP8
7asthma30.7CSN1S1, CD79A, OXA1L, MMP8
8diabetes mellitus30.6CSN1S1, CD79A, OXA1L
9arthritis30.4CSN1S1, MMP8, LTF
10rheumatoid arthritis29.8DSPP, LTF, CD79A, CSN1S1, OXA1L, MMP8
11obesity10.7
12urethritis10.5CD79A
13reactive arthritis10.5CD79A
14cryptosporidiosis10.5CD79A
15keratoconjunctivitis sicca10.5LTF
16gastroenteritis10.5CD79A
17hyperthyroxinemia10.5OXA1L
18enamel caries10.4
19dentin caries10.4
20bronchiectasis10.4MMP8, CD79A
21gastroesophageal reflux disease10.4DSPP, CSN1S1
22lactose intolerance10.4CSN1S1, LTF
23prostatitis10.4CD79A, LTF
24shigellosis10.4LTF, CD79A
25perinatal necrotizing enterocolitis10.3LTF, CSN1S1
26cerebral palsy10.3
27type 1 diabetes mellitus10.3
28down syndrome10.3
29cerebritis10.3
30chorioamnionitis10.3LTF, MMP8
31otitis media10.3CD79A, LTF
32abdominal aortic aneurysm10.3CSN1S1, MMP8
33mastitis10.3LTF, CSN1S1
34candidiasis10.3CD79A, LTF
35connective tissue disease10.3DSPP, LTF
36celiac disease10.3CD79A, CSN1S1
37amelogenesis imperfecta10.3DSPP, AMELX
38diphtheria10.3CD79A, CSN1S1
39amyloidosis10.2CSN1S1, CD79A
40cystic fibrosis10.2
41graft versus host disease10.2
42hemangioma10.2
43cleft lip10.2
44odontoclasia10.2
45endocarditis10.2
46periapical periodontitis10.2
47tooth disease10.2
48berger disease10.2CSN1S1, CD79A
49diarrhea10.2CD79A, LTF, CSN1S1
50atopy10.2CD79A, CSN1S1

Graphical network of the top 20 diseases related to Dental Caries:



Diseases related to dental caries

Symptoms for Dental Caries

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Drugs & Therapeutics for Dental Caries

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Drug clinical trials:

Search ClinicalTrials for Dental Caries

Search NIH Clinical Center for Dental Caries

Genetic Tests for Dental Caries

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Anatomical Context for Dental Caries

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MalaCards organs/tissues related to Dental Caries:

32
Salivary gland, Bone marrow, Bone, Colon, Kidney, Testes

Animal Models for Dental Caries or affiliated genes

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Publications for Dental Caries

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Articles related to Dental Caries:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Fluoride and dental caries prevention in children. (24385561)
2014
2
The use of sub-ablative Er:YAG laser irradiation in prevention of dental caries during orthodontic treatment. (25368443)
2014
3
The Role of Behaviour in Inequality in Increments of Dental Caries among Finnish Adults. (25401295)
2014
4
Total antioxidant capacity of saliva and dental caries. (23524431)
2013
5
Influence of feeding practices on dental caries. A case-control study. (23597222)
2013
6
Antimicrobial activity of fractions and subfractions of Elaeagia utilis against microorganisms of importance in dental caries. (24303734)
2013
7
Association signals unveiled by a comprehensive gene set enrichment analysis of dental caries genome-wide association studies. (23967329)
2013
8
Dental caries experience and barriers to care in young children with disabilities in Ireland. (23444182)
2013
9
Dental caries and chemical analyses in reconstruction of diet, health and hygienic behaviour in the Middle Euphrates valley (Syria). (23352446)
2013
10
Relationship between dental caries status and anemia in children with severe early childhood caries. (23684139)
2013
11
Dental caries vaccine - a possible option? (23905153)
2013
12
Antibacterial agents in composite restorations for the prevention of dental caries. (24343855)
2013
13
Innovative interventions to promote positive dental health behaviors and prevent dental caries in preschool children: study protocol for a randomized controlled trial. (23782918)
2013
14
Dentists who participate in a practice-based research network may adopt less invasive approaches to treating dental caries. (24237740)
2013
15
Dental caries and oral health practice among 12 year old school children from low socio-economic status background in Zimbabwe. (23819006)
2013
16
Management of dental caries and esthetic issues in the pediatric patient. (24073501)
2013
17
Dental caries prevalence, oral health knowledge and practice among indigenous Chepang school children of Nepal. (23672487)
2013
18
Pulpal involvement-roots-sepsis index: a new method for describing the clinical consequences of untreated dental caries. (23949116)
2013
19
Salivary proteins as a biomarker for dental caries--a systematic review. (23142096)
2013
20
Nonfluoride caries preventive agents show varied effectiveness in preventing dental caries. (22726784)
2012
21
Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis. (23091642)
2012
22
Cost-effectiveness models for dental caries prevention programmes among Chilean schoolchildren. (23488214)
2012
23
MMP13 polymorphism decreases risk for dental caries. (22710194)
2012
24
Fluorosis and dental caries: an assessment of risk factors in Mexican children. (22690531)
2012
25
Exploring the relation between body mass index, diet, and dental caries among 6-12-year-old children. (23514680)
2012
26
Effect of inhaled medication and inhalation technique on dental caries in asthmatic patients. (23483765)
2012
27
Decline in dental caries among 12-year-old children in Brazil, 1980-2005. (23252588)
2012
28
Preventing dental caries in children: Indian scenario. (22971868)
2012
29
Alloxan-induced hyperglycemia causes rapid-onset and progressive dental caries and periodontitis in F344 rats. (22936448)
2012
30
Dental Caries in the Primary Dentition of German Children With Cleft Lip and Palate. (23237430)
2012
31
The natural history of dental caries lesions: a 4-year observational study. (22821238)
2012
32
Inter-relationship of intelligence-quotient and self-concept with dental caries amongst socially handicapped orphan children. (22918097)
2012
33
Antibacterial photodynamic therapy for dental caries: evaluation of the photosensitizers used and light source properties. (22594982)
2012
34
Monitoring time-related trends in dental caries in permanent teeth in Japanese national surveys. (22420480)
2012
35
Asthma and dental caries. (22722409)
2012
36
Development of an auxiliary resource for diagnosis of dental caries in epidemiological surveys. (21689374)
2011
37
Dental caries trends in Australian school children. (21770083)
2011
38
Oral health among white, black, and Mexican-American elders: an examination of edentulism and dental caries. (22320289)
2011
39
New directions in the etiology of dental caries disease. (22132583)
2011
40
Association between occlusal anomalies and dental caries in 3- to 5 year-old Brazilian children. (21367823)
2011
41
Dental caries in rats associated with Candida albicans. (21412001)
2011
42
Changes in dental caries in Zurich school-children over a period of 45 years. (21243546)
2010
43
Dental caries as a side effect of infantile hemangioma treatment with propranolol solution. (21510011)
2010
44
Dental caries profile in Monte Negro, Amazonian state of RondA'nia, Brazil, in 2008. (21085797)
2010
45
Dental caries experience among young Australian adults. (21174922)
2010
46
Oral health status, dental caries risk factors of the children of public kindergarten and schools in Phranakornsriayudhya, Thailand. (21284137)
2010
47
Considerations on optimal fluoride intake using dental fluorosis and dental caries outcomes--a longitudinal study. (19054310)
2009
48
Molluscum contagiosum and dental caries: a pertinent combination. (19915268)
2009
49
Hydrophobic interaction chromatography and capillary zone electrophoresis to explore the correlation between the isoenzymes of salivary alpha-amylase and dental caries. (10219681)
1999
50
Dental caries and dental fluorosis. (3226636)
1988

Variations for Dental Caries

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Expression for genes affiliated with Dental Caries

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Expression patterns in normal tissues for genes affiliated with Dental Caries

Search GEO for disease gene expression data for Dental Caries.

Pathways for genes affiliated with Dental Caries

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Pathways related to Dental Caries according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8LTF, MMP8
29.6LTF, NR5A2

Compounds for genes affiliated with Dental Caries

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Sources:
44Novoseek, 2BitterDB, 11DrugBank, 24HMDB, 50PharmGKB, 28IUPHAR
See all sources

Compounds related to Dental Caries according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1chlorhexidine44 2 1112.3DSPP, LTF
2hypothiocyanite44 2411.2CD79A, LTF
3lactulose4410.2CD79A, LTF
4thiocyanate44 2411.1CD79A, LTF
5pneumococcal4410.1LTF, CD79A
6amoxicillin44 50 1112.1LTF, DSPP
7metronidazole44 1111.0DSPP, LTF
8polyacrylic acid4410.0DSPP, CSN1S1
9exorphins449.9CSN1S1, LTF
10gluten449.9CD79A, CSN1S1
11trichloroacetic acid449.9DSPP, CSN1S1
12sodium fluoride449.8CSN1S1, DSPP
13ctab449.7DSPP, OXA1L
14nitrilotriacetic acid44 1110.7OXA1L, LTF
15fluoride449.7DSPP, CD79A, CSN1S1
16chloramine t449.7DSPP, OXA1L
17doxycycline44 1110.7CD79A, DSPP, MMP8, LTF
18citric acid44 28 24 1112.6DSPP, LTF, CSN1S1
19cacl2449.6CSN1S1, MMP8
20phenolphthalein44 1110.6LTF, OXA1L
21vitamin b12449.6CD79A, CSN1S1, LTF
22tartrate449.6OXA1L, DSPP
23chloroform449.5OXA1L, DSPP
24formaldehyde44 2410.5CSN1S1, DSPP, CD79A
25carbohydrates449.5LTF, CSN1S1, DSPP
26gliadin449.5CSN1S1, CD79A
27piroxicam44 1110.4OXA1L, CD79A
28tween 80449.4OXA1L, CSN1S1
29deae449.4CSN1S1, OXA1L
30citrate449.4DSPP, CSN1S1, LTF, CD79A
31ascorbic acid44 2410.3CD79A, DSPP, LTF, CSN1S1
32lactate449.3CD79A, CSN1S1, MMP8, DSPP
33glycerol44 24 1111.3CD79A, CSN1S1, DSPP
34whey449.2LTF, CSN1S1
35phosphatidylcholine449.2CSN1S1, CD79A, LTF
36tannins449.2CSN1S1, OXA1L, DSPP
37pmma449.2OXA1L, DSPP, CD79A, LTF
38salicylic acid44 2810.2OXA1L, CSN1S1, DSPP
39polyethylene glycol449.1OXA1L, CD79A, CSN1S1
40diazepam44 28 50 1112.1OXA1L, CSN1S1, LTF
41sodium dodecylsulfate449.1CD79A, OXA1L, CSN1S1
42alanine449.0MMP8, LTF, CD79A, CSN1S1, DSPP
43thyroxine44 2410.0CD79A, CSN1S1, OXA1L
44glutaraldehyde448.9OXA1L, DSPP, CD79A, CSN1S1
45pge2448.8CD79A, NR5A2, CSN1S1, LTF, MMP8
46estrogen448.8CSN1S1, CD79A, LTF, DSPP, NR5A2
47retinoic acid44 249.7CSN1S1, LTF, CD79A, MMP8, NR5A2
48fibrinogen448.5LTF, MMP8, CD79A, CSN1S1, OXA1L
49h2o2448.2CD79A, DSPP, MMP8, LTF, CSN1S1, OXA1L
50cysteine448.2DSPP, MMP8, OXA1L, LTF, CD79A, CSN1S1

GO Terms for genes affiliated with Dental Caries

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Cellular components related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.5MMP8, DSPP, AMELX

Biological processes related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ossificationGO:0015039.8LTF, DSPP
2biomineral tissue developmentGO:0312149.7DSPP, AMELX
3odontogenesis of dentin-containing toothGO:0424759.4NKX2-3, AMELX

Products for genes affiliated with Dental Caries

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  • Antibodies
  • Proteins
  • Lysates

Sources for Dental Caries

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet