MCID: DNT012
MIFTS: 46

Dental Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Caries

MalaCards integrated aliases for Dental Caries:

Name: Dental Caries 12 52 42 14 69
Dental Caries Extending into Pulp 12
Dental Caries of Smooth Surface 12
Dental Caries Pit and Fissure 12

Classifications:



External Ids:

Disease Ontology 12 DOID:216
ICD10 33 K02 K02.6 K02.9
MeSH 42 D003731
NCIt 47 C52593

Summaries for Dental Caries

MalaCards based summary : Dental Caries, also known as dental caries extending into pulp, is related to root caries and dentin caries, and has symptoms including halitosis and snoring. An important gene associated with Dental Caries is CD79A (CD79a Molecule), and among its related pathways/superpathways is Salivary secretion. The drugs sodium fluoride and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, testes and bone, and related phenotype is Decreased viability.

Related Diseases for Dental Caries

Diseases related to Dental Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 root caries 11.6
2 dentin caries 11.5
3 enamel caries 11.2
4 periapical periodontitis 11.0
5 aplasia of lacrimal and salivary glands 11.0
6 tricho-dento-osseous syndrome 1 11.0
7 cockayne syndrome, type a 10.9
8 osteopetrosis, autosomal recessive 1 10.9
9 cutis laxa, autosomal recessive, type iia 10.9
10 flynn-aird syndrome 10.9
11 benjamin syndrome 10.9
12 dominant dystrophic epidermolysis bullosa 10.9
13 sialadenitis 10.7 CD79A LTF
14 asymptomatic dengue 10.7 CD79A LTF
15 hyperlipoproteinemia, type 1d 10.7 AMELX ENAM
16 accommodative spasm 10.7 AMELX DSPP
17 eye disease 10.7 DSPP ENAM
18 arrhythmogenic right ventricular dysplasia 3 10.7 AMELX TUFT1
19 basal cell carcinoma 10.7 DSPP TUFT1
20 lissencephaly with cerebellar hypoplasia type b 10.6 AMELX ENAM
21 mental retardation, x-linked 104 10.6 AMELX TUFT1
22 corneal staphyloma 10.6 DSPP ENAM
23 unilateral hypoactive labyrinth 10.6 CD79A LYZ
24 neuroschistosomiasis 10.6 AMELX DSPP
25 odontoclasia 10.6
26 bronchus cancer 10.5 AMELX DSPP
27 infertility due to extratesticular cause 10.5 CD79A DSPP LTF
28 immune-complex glomerulonephritis 10.5 CD79A LYZ
29 epulis 10.5 AMELX DSPP
30 bullous retinoschisis 10.5 CD79A DSPP
31 uveitis 10.5 CD79A LYZ
32 dental fluorosis 10.5
33 lymphocytic colitis 10.5 CD79A LYZ
34 lissencephaly with cerebellar hypoplasia type e 10.4 DSPP ENAM TUFT1
35 periodontitis 10.4
36 postinflammatory pulmonary fibrosis 10.3 CD79A LYZ
37 tooth disease 10.3
38 obesity 10.3
39 glycogen storage disease viii 10.3 CD79A LYZ
40 toxic myocarditis 10.3 CD79A LYZ
41 periodontal disease 10.2
42 discitis 10.2 CD79A LYZ
43 lip carcinoma in situ 10.1 CD79A LTF
44 gingivitis 10.1
45 laron dwarfism 10.1 DSPP FGF10 LPO LTF
46 down syndrome 10.0
47 cerebral palsy 10.0
48 asthma 10.0
49 cerebritis 10.0
50 ovarian malignant mesothelioma 9.9 AMELX CD79A DSPP ENAM TUFT1

Comorbidity relations with Dental Caries via Phenotypic Disease Network (PDN): (show all 13)


Acute Apical Periodontitis Acute Cystitis
Acute Pericementitis Alzheimer Disease
Deficiency Anemia Familial Atrial Fibrillation
Gingivitis Heart Disease
Ischemic Heart Disease Left Ventricular Outflow Tract Obstruction
Periodontitis Periodontosis
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Dental Caries:



Diseases related to Dental Caries

Symptoms & Phenotypes for Dental Caries

UMLS symptoms related to Dental Caries:


halitosis, snoring

GenomeRNAi Phenotypes related to Dental Caries according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.56 TUFT1 CD79A LTF TAS1R2
2 Decreased viability GR00381-A-3 9.56 TUFT1 CD79A LTF TAS1R2
3 Increased gamma-H2AX phosphorylation GR00053-A 9.28 AJAP1 CD79A CST1 DSPP HTN1 LTF

Drugs & Therapeutics for Dental Caries

Drugs for Dental Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 247)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7681-49-4
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Salicylic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2 69-72-7 338
4
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
5
Methamphetamine Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 537-46-2 10836
6
Sorbitol Approved Phase 4,Phase 2,Phase 3 50-70-4 5780
7
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 55-56-1 9552079 2713
8
Zinc Approved Phase 4 7440-66-6 32051 23994
9
Zinc oxide Approved Phase 4 1314-13-2
10
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
11
Midazolam Approved, Illicit Phase 4,Phase 2 59467-70-8 4192
12
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
13
Ethanol Approved Phase 4 64-17-5 702
14
Chloramphenicol Approved, Vet_approved Phase 4 56-75-7 298 5959
15
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
16
Glycerol Approved, Investigational Phase 4 56-81-5 753
17
Thymol Approved Phase 4 89-83-8 6989
18
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
19
Chloramphenicol succinate Experimental Phase 4 3544-94-3
20 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Fluorides Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Cariostatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Olaflur Phase 4
24 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
26 Anti-Infective Agents, Local Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
27 Fluorides, Topical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Listerine Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Antifungal Agents Phase 4
32 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Keratolytic Agents Phase 4
34 Sodium fluoride topical preparation Phase 4,Phase 2
35 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Central Nervous System Stimulants Phase 4,Phase 3,Phase 2,Phase 1
38 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Dopamine Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
40 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Cathartics Phase 4,Phase 2,Phase 3
44 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
45 Laxatives Phase 4,Phase 2,Phase 3
46 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Phase 1
47 Disinfectants Phase 4,Phase 3,Phase 2,Phase 1
48 Analgesics Phase 4,Phase 2
49 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Anti-Anxiety Agents Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 518)

id Name Status NCT ID Phase Drugs
1 Dental Caries Management by Risk Assessment: Identification and Treatment of Risk Factors Among (IDF) Personnel Unknown status NCT01142440 Phase 4
2 Elmex Gel Efficacy in Preventing White Spot Lesions Unknown status NCT00268138 Phase 4 elmex gel
3 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). Unknown status NCT01778699 Phase 4
4 Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars Completed NCT02592278 Phase 4 Fluoride Varnish;Control Group
5 Therapeutic Effect of Two Fluoride Varnishes on White Spot Lesions: a Clinical Study Completed NCT00723515 Phase 4 sodium fluoride;sodium fluoride calcium fluoride
6 Effectiveness of Fluoride Varnish in the Prevention of Early Childhood Caries: A Randomized Controlled Trial Completed NCT02742038 Phase 4
7 Use of Fissure Sealants on Primary Molars Completed NCT01438866 Phase 4
8 Impact of Fluoride Vanish Application in Dental Prevention for Elderly Completed NCT01038817 Phase 4 Duraphat
9 Preventive and Therapeutic Proximal Sealants Completed NCT02338180 Phase 4
10 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions Completed NCT02953886 Phase 4
11 Fluoride Varnish For Childsmile Nursery School Attenders Completed NCT01674933 Phase 4 Duraphat® Fluoride Varnish
12 Impact of Maternal Xylitol Consumption on Mutans Sterptococci Completed NCT02036151 Phase 4 xylitol;fluoride varnish application
13 Fuji Type VII Sealant Versus Resin Based Sealant. A Clinical Trial Completed NCT02795728 Phase 4
14 Caries-preventive Effect of a Dentifrice Containing 5,000 Ppm Fluoride in Orthodontic Patients Completed NCT01768390 Phase 4
15 Enamel Remineralization Potential of Dentifrices in Situ Completed NCT01128946 Phase 4 NaF;SnF;NaMFP
16 Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride Completed NCT01563172 Phase 4 Sodium fluoride / silica and carbopol, 0.5g;Sodium fluoride / silica and carbopol, 1.5g;Sodium fluoride / silica and carbopol, 1.5g
17 Comparison of the Effect of Fluoride Remineralizer Gel and Foam Completed NCT02490592 Phase 4
18 Postoperative Pulpal Complications in Posterior Resin Composite Restorations Without Glass-ionomer Cement Lining Completed NCT01567514 Phase 4
19 MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study Completed NCT02424097 Phase 4 CPP-ACP 5% sodium fluoride varnish & 900ppm fluoride paste;1,100pm F-toothpaste and 0.5%NaF rinse
20 Bifidobacterium Lactis BB12 and Xylitol Delivered With a Novel Slow-release Pacifier Completed NCT00638677 Phase 4
21 Interaction Between Chlorhexidine and Fluoride Completed NCT02935322 Phase 4 0.12 % chlorhexidine + 0.2 % NaF mouthrinse;0.2 % NaF mouthrinse;0.12% chlorhexidine
22 Efficacy of Moderate Sedation for Dental Treatment of Young Children Completed NCT00902395 Phase 4 Midazolam;Midazolam, ketamine
23 Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing Completed NCT02921165 Phase 4 analgesic mouth rinses (dissolved Aspirin);Normal saline rinses.
24 Effects of Two Sugar Substituted Chewing Gums on Caries and Gingivitis Variables Completed NCT01578603 Phase 4
25 Remineralisation of White Spot Lesions by Elmex® gelée in Post-orthodontic Patients Completed NCT01329731 Phase 4 elmex® gelée;negative control (placebo)
26 Antimicrobial Pulpotomy of Primary Molars Completed NCT01010451 Phase 4
27 Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study Completed NCT01601145 Phase 4
28 Music Distraction Strategy in Children Dental Care Completed NCT02489812 Phase 4
29 Oral Fluoride Bioavailability by the Consumption of Meals Prepared With Fluoridated Water or Salt Completed NCT02776280 Phase 4
30 Nano-hydroxyapatite With Potassium Nitrate in the Therapy of the Dental Sensitivity Completed NCT02895321 Phase 4
31 Midazolam Efficacy for Sedating Preschoolers Undergoing Dental Treatment Completed NCT01795222 Phase 4 Midazolam;Placebo
32 Occlusal Caries Management in First Permanent Molars in Child Dental Care Recruiting NCT03315312 Phase 4 Fluoride Varnishes;Fissure Sealants
33 Consumption Effect of Probiotic Products on Salivary Cariogenic Bacterial Counts in Preschool Children. Recruiting NCT02692625 Phase 4
34 Cost-efficacy Between ART and Composite Resin Restorations in Primary Molars Recruiting NCT02562456 Phase 4
35 Effectiveness and Economic Evaluation of Glass Ionomer Material Using as Dental Sealant Recruiting NCT03034837 Phase 4 resin sealant;ART sealant
36 Midazolam and Ketamine Effect Administered Through the Nose for Sedation of Children for Dental Treatment Active, not recruiting NCT02447289 Phase 4 Intranasal ketamine;Oral ketamine;Intranasal midazolam;Oral midazolam
37 Cost-efficacy of Atraumatic Restorations (ART) Using Different Encapsulated Glass Ionomer Cement Active, not recruiting NCT02730000 Phase 4
38 Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial Active, not recruiting NCT02201641 Phase 4
39 A Clinical Trial to Assess the Retention and Caries Preventive Effects of Moisture Tolerant Resin Sealant and ART Sealants Active, not recruiting NCT02716558 Phase 4
40 Effectiveness Of Art Restorations Using Three Different Materials Not yet recruiting NCT02962713 Phase 4
41 Treatment of Postorthodontic White Spot Lesions Not yet recruiting NCT03217084 Phase 4 MI varnish GC;White varnish 3M
42 Intranasal Sedation With Dexmedetomidine and Ketamine in Pediatric Dentistry (NASO II) Not yet recruiting NCT03290625 Phase 4 Dexmedetomidine Hydrochloride;Ketamine Hydrochloride
43 The Effects of Chlorhexidine/Thymol Varnish on Partial Denture Patient Withdrawn NCT02202304 Phase 4 Chlorhexidine/Thymol varnish
44 Fluoride Varnish in the Prevention of Dental Caries in Aboriginal and Non-aboriginal Children Unknown status NCT00435500 Phase 3 Fluoride varnish
45 Three Measures for the Prevention of Carious Lesions in Preschool Children Unknown status NCT02341352 Phase 3 fluoride varnish
46 Effect of Erythritol and Xylitol on Dental Caries Prevention in Children Unknown status NCT01062633 Phase 2, Phase 3
47 Preventing Early Childhood Caries in Indigenous Children: the Baby Teeth Talk Study Unknown status NCT02151916 Phase 3
48 Evaluation of Implants Placed Immediately or Delayed Into Extraction Sites Unknown status NCT00067392 Phase 3
49 Using Combination of Synthetic Bone Substitutes During Extractions Unknown status NCT01503593 Phase 3
50 Arresting Active Dental Caries in Preschool Children by Topical Fluorides Completed NCT02426619 Phase 2, Phase 3

Search NIH Clinical Center for Dental Caries

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: dental caries

Genetic Tests for Dental Caries

Anatomical Context for Dental Caries

MalaCards organs/tissues related to Dental Caries:

39
Salivary Gland, Testes, Bone, Heart, Neutrophil, Kidney, Colon

Publications for Dental Caries

Articles related to Dental Caries:

(show top 50) (show all 729)
id Title Authors Year
1
Occurrence of vancomycin-resistant Staphylococcus aureus in the oral cavity of patients with dental caries. ( 28889756 )
2017
2
Prevalence of Dental Caries and Traumatic Dental Injuries among 6- to 12-year-old Children in Bhopal City, India. ( 28890618 )
2017
3
Untreated Dental Caries Is Associated with Reports of Verbal Bullying in Children 8-10 Years Old. ( 28954260 )
2017
4
Risk factors and prevalence of dental fluorosis and dental caries in school children of North India. ( 28025807 )
2017
5
Effectiveness of water fluoridation in the prevention of dental caries across adult age groups. ( 28092105 )
2017
6
Trends in dental caries rates over 45 years (1971-2016) among schoolchildren in FlorianA^polis, southern Brazil. ( 28880993 )
2017
7
Intricate Evaluation of Association between Dental Caries and Obesity among the Children in Al-Kharj City (Saudi Arabia). ( 28050981 )
2017
8
Association between socio-economic status and dental caries in elderly people in Sichuan Province, China: a cross-sectional study. ( 28947446 )
2017
9
Second-generation Flagellin-rPAc Fusion Protein, KFD2-rPAc, Shows High Protective Efficacy against Dental Caries with Low Potential Side Effects. ( 28894188 )
2017
10
Assessment of Vitamin B12 and Its Correlation with Dental Caries and Gingival Diseases in 10- to 14-year-old Children: A Cross-sectional Study. ( 28890613 )
2017
11
Prevalence and severity of dental caries among public school students aged 16-l8 in Hai'l, Kingdom of Saudi Arabia. ( 28936152 )
2017
12
Low sugar nutrition policies and dental caries: A study of primary schools in South Auckland. ( 28073166 )
2017
13
Hypomineralised second primary molars: prevalence, defect characteristics and relationship with dental caries in Melbourne preschool children. ( 28881480 )
2017
14
Association between Low blood lead levels and increased risk of dental caries in children: a cross-sectional study. ( 28086936 )
2017
15
Bayesian Analysis of the Association between Family-Level Factors and Siblings' Dental Caries. ( 28871287 )
2017
16
Tooth loss, periodontal disease, and dental caries may be associated with decreased oral health-related quality of life, but there is no evidence about the magnitude of this association. ( 28821339 )
2017
17
The Influence of Sweet Taste Perception on Dietary Intake in Relation to Dental Caries and BMI in Saudi Arabian Schoolchildren. ( 28912812 )
2017
18
Type 2 diabetes as a risk indicator for dental caries in Korean adults: the 2011-2012 Korea national health and nutrition examination survey. ( 28872812 )
2017
19
Fluoride mouthrinses for preventing dental caries in children and adolescents. ( 28944499 )
2017
20
The Lack of Association between FCN2 Gene Promoter Region Polymorphisms and Dental Caries in Polish Children. ( 28088794 )
2017
21
Are people with an orofacial cleft at a higher risk of dental caries? A systematic review and meta-analysis. ( 28684841 )
2017
22
Parents' online discussions about children's dental caries: A critical content analysis. ( 28910248 )
2017
23
Long-term Hyperglycemia Naturally Induces Dental Caries But Not Periodontal Disease in Type-1 and Type-2 Diabetic Rodents. ( 28793985 )
2017
24
The Role of Genetic Factors in the Outbreak Mechanism of Dental Caries. ( 28937897 )
2017
25
Relationship of salivary CD14 concentration with dental caries in young children. ( 28936284 )
2017
26
Oral Health-Promoting School Environments and Dental Caries in QuAcbec Children. ( 28869092 )
2017
27
Assessment of dental caries, oral hygiene status, traumatic dental injuries and provision of basic oral health care among visually impaired children of Eastern Odisha. ( 28914238 )
2017
28
The impact of MUC5B gene on dental caries. ( 28944591 )
2017
29
Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries. ( 28100911 )
2017
30
Feeding frequency in infancy and dental caries in childhood: a prospective cohort study. ( 28868798 )
2017
31
Effect of Silver Nanoparticle-Added Pit and Fissure Sealant in the Prevention of Dental Caries in Children. ( 28052214 )
2017
32
Analysis of Forecasting Indexes for Dental Caries a8"in 3- to 6-year-old Children. ( 27622218 )
2016
33
Assessment of dental caries prevention program applied to a cohort of elementary school children of Kebemer, a city in Senegal. ( 27652240 )
2016
34
The Association of Socioeconomic Status and Dental Caries Experience in Children in Dili, Timor-Leste. ( 27620835 )
2016
35
Utilization of teledentistry as a tool to screen for dental caries among 12-year-old school children in a rural region of India. ( 28035658 )
2016
36
Prevention of dental caries: A review of effective treatments. ( 27957278 )
2016
37
Association between dental caries and body mass in preschool children. ( 27160759 )
2016
38
Prevalence of dental caries and influencing factors, time trends over a 30-year period in an adult population. Epidemiological studies between 1983 and 2013 in the county of Dalarna, Sweden. ( 27215270 )
2016
39
Semiannual Fluoride Applications in Low-Risk Toddlers May Not Be More Effective Than Toothbrushing Instruction and Dietary Counseling in Controlling Dental Caries. ( 27938699 )
2016
40
Sense of coherence modifies the association between untreated dental caries and dental pain in low-social status women. ( 27149775 )
2016
41
School-Based Fluoride Mouth-Rinse Program Dissemination Associated With Decreasing Dental Caries Inequalities Between Japanese Prefectures: An Ecological Study. ( 27108752 )
2016
42
Discrete Distribution Based on Compound Sum to Model Dental Caries Count Data. ( 28006773 )
2016
43
A correlative study of the levels of salivary Streptococcus mutans, lactobacilli and Actinomyces with dental caries experience in subjects with mixed and permanent dentition. ( 27194858 )
2016
44
Prevalence of Dental Caries in Kosovar Adult Population. ( 27516774 )
2016
45
Antipsychotic medications and dental caries in newly diagnosed schizophrenia: A nationwide cohort study. ( 27526316 )
2016
46
Association of ENAM gene single nucleotide polymorphisms with dental caries in Polish children. ( 26910531 )
2016
47
Association between body mass index, diet and dental caries in Grade 6 boys in Medina, Saudi Arabia. ( 27966771 )
2016
48
Prevalence of dental caries and associated social risk factors among preschool children in Riyadh, Saudi Arabia. ( 27182260 )
2016
49
Comparison of Dental Caries Experience in Children Suffering From Epilepsy with and without Administration of Long Term Liquid Oral Medication. ( 27504416 )
2016
50
Ethnic Disparities in Dental Caries among Six-Year-Old Children in the Netherlands. ( 27595263 )
2016

Variations for Dental Caries

Expression for Dental Caries

Search GEO for disease gene expression data for Dental Caries.

Pathways for Dental Caries

Pathways related to Dental Caries according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.38 CST1 HTN1 LPO LYZ MUC7 PRH1

GO Terms for Dental Caries

Cellular components related to Dental Caries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CA6 CST1 FGF10 LPO LTF LYZ
2 proteinaceous extracellular matrix GO:0005578 9.56 AMELX DSPP ENAM TFIP11
3 extracellular region GO:0005576 9.47 AMELX CA6 CST1 DSPP ENAM FGF10
4 other organism cell membrane GO:0044218 8.96 LTF MUC7

Biological processes related to Dental Caries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.71 AMELX ENAM LTF LYZ
2 defense response to bacterium GO:0042742 9.65 HTN1 LPO LTF LYZ STATH
3 ossification GO:0001503 9.63 DSPP LTF STATH
4 odontogenesis of dentin-containing tooth GO:0042475 9.54 AMELX ENAM FGF10
5 antimicrobial humoral response GO:0019730 9.5 HTN1 LTF LYZ
6 detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 9.46 CA6 CST1 LPO TAS2R38
7 killing of cells of other organism GO:0031640 9.26 HTN1 LTF LYZ MUC7
8 negative regulation of cysteine-type endopeptidase activity GO:2000117 9.18 LTF
9 biomineral tissue development GO:0031214 9.17 AMELX DSPP ENAM HTN1 STATH TFIP11
10 defense response to Gram-negative bacterium GO:0050829 9.13 LTF

Molecular functions related to Dental Caries according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lysozyme activity GO:0003796 9.16 LYZ LYZL2
2 hydroxyapatite binding GO:0046848 8.96 AMELX STATH
3 structural constituent of tooth enamel GO:0030345 8.92 AMELX ENAM STATH TUFT1

Sources for Dental Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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