MCID: DNT012
MIFTS: 46

Dental Caries malady

Gastrointestinal category

Summaries for Dental Caries

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Dental caries, also known as tooth decay or a cavity, is an infection, bacterial in origin, that causes... more...

MalaCards: Dental Caries, also known as dental caries extending into pulp, is related to root caries and aggressive periodontitis. An important gene associated with Dental Caries is DSPP (dentin sialophosphoprotein). The compounds cysteine and h2o2 have been mentioned in the context of this disorder.

Aliases & Classifications for Dental Caries

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 40NCIt, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

dental caries 8 10 45
dental caries extending into pulp 8
dental caries of smooth surface 8
dental caries pit and fissure 8
caries 61


External Ids:

Disease Ontology8 DOID:216
ICD9CM27 521.00, 521.0
NCIt40 C52593
MeSH35 D003731
ICD1025 K02

Related Diseases for Dental Caries

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Dental Caries via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1root caries30.7DSPP
2aggressive periodontitis30.1LTF, MMP8
3arthritis30.1CSN1S1, LTF, MMP8, LYZ
4lactose intolerance29.7LTF, CSN1S1
5dental fluorosis10.9
6enamel caries10.6
7dentin caries10.5
8dent's disease10.5
9asthma10.5
10curly hair-acral keratoderma-caries syndrome10.3
11graft versus host disease10.2
12cystic fibrosis10.2
13cleft palate10.2
14chronic graft versus host disease10.2
15attention deficit hyperactivity disorder10.1
16molluscum contagiosum10.1
17pulpitis10.1
18odontoclasia10.1
19subacute bacterial endocarditis10.1
20renal tubular acidosis10.1
21atherosclerosis10.1
22tooth disease10.1
23benjamin syndrome10.1
24cutis laxa, autosomal recessive type 2a10.1
25osteopetrosis autosomal recessive 110.1
26cockayne syndrome type i10.1
27generalized dominant dystrophic epidermolysis bullosa10.1
28dent disease 210.1
29exercise induced anaphylaxis10.1
30tricho-dento-osseous syndrome 110.1
31cardiovascular disease risk factor10.1
32recessive dystrophic epidermolysis bullosa10.1
33h. pylori infection10.1
34sepsis10.1
35periodontal disease10.0MMP8, CD79A, LTF, DSPP
36gingivitis10.0MMP8, LTF, DSPP
37factor v leiden thrombophilia10.0CSN1S1, DSPP, OXA1L, MMP8
38tetanus10.0CSN1S1, OXA1L, CD79A
39dentinogenesis imperfecta 110.0DSPP, DMP1
40amyloidosis10.0CSN1S1, CD79A, LYZ
41periodontitis10.0MMP8
42keratitis10.0OXA1L
43systemic lupus erythematosus10.0CSN1S1, OXA1L, LTF, CD79A
44protein-energy malnutrition10.0CSN1S1
45connective tissue disease10.0CD79A
46mastitis10.0LYZ, LTF, CSN1S1
47reactive arthritis10.0CD79A
48keratoconjunctivitis sicca10.0LTF
49root resorption10.0
50n syndrome10.0

Graphical network of the top 20 diseases related to Dental Caries:



Diseases related to dental caries

Clinical Features for Dental Caries

Drugs & Therapeutics for Dental Caries

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Dental Caries

Drug clinical trials:

Search ClinicalTrials for Dental Caries

Search NIH Clinical Center for Dental Caries

Search CenterWatch for Dental Caries

Genetic Tests for Dental Caries

Anatomical Context for Dental Caries

Animal Models for Dental Caries or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Dental Caries

Sources:
51PubMed
See all sources

Articles related to Dental Caries:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
Arresting rampant dental caries with silver diamine fluoride in a young teenager suffering from chronic oral graft versus host disease post-bone marrow transplantation: a case report. (24383434)
2014
2
Cross-cultural validity of a dietary questionnaire for studies of dental caries risk in Japanese. (24383547)
2014
3
Antimicrobial activity of fractions and subfractions of Elaeagia utilis against microorganisms of importance in dental caries. (24303734)
2013
4
Effects of fluoridated drinking water on dental caries in Australian adults. (23456704)
2013
5
Dental caries: Strategies to control this preventable disease. (24308392)
2013
6
Association of GLUT2 and TAS1R2 genotypes with risk for dental caries. (23257979)
2013
7
Dental caries in older adults in the last year of life. (23865859)
2013
8
Fluorosis and dental caries in Mexican schoolchildren residing in areas with different water fluoride concentrations and receiving fluoridated salt. (23406606)
2013
9
Anti-nociceptive properties in rodents and the possibility of using Polyphenol-rich fractions from sida urens L. (Malvaceae) against of dental caries Bacteria. (23787152)
2013
10
Low-fluoride toothpastes may not lead to dental fluorosis but may not control caries development. Standard fluoride toothpastes can control caries development but may lead to dental fluorosis. (24237735)
2013
11
Ameloglyphics and predilection of dental caries. (24250075)
2013
12
Multi-dimensional prioritization of dental caries candidate genes and its enriched dense network modules. (24146904)
2013
13
Fluorosis and dental caries: an assessment of risk factors in Mexican children. (22690531)
2012
14
Assessment of dental caries risk in children based on color Doppler US and the changes in blood perfusion in the salivary glands during salivary stimulation. (21918953)
2012
15
Association of anthropometric measures and dental caries among a group of adolescent cadets of Udupi district, South India. (23043883)
2012
16
Family context and incidence of dental caries in preschool children living in areas covered by the Family Health Strategy in Salvador, Bahia State, Brazil. (22666822)
2012
17
Statistical analysis of dental caries: different methods for different outcomes. (22710309)
2012
18
Pro-inflammatory cytokines in saliva of adolescents with dental caries disease. (23311795)
2012
19
The association between social deprivation and the prevalence and severity of dental caries and fluorosis in populations with and without water fluoridation. (23272895)
2012
20
Epidemiology of dental caries among adults in a rural area in India. (22918014)
2012
21
Nonnutritive, low caloric substitutes for food sugars: clinical implications for addressing the incidence of dental caries and overweight/obesity. (22505906)
2012
22
Genome-wide association scan of dental caries in the permanent dentition. (23259602)
2012
23
Does intellectual disability affect the development of dental caries in patients with cerebral palsy? (22522208)
2012
24
A novel delivery system of probiotic drop and its effect on dental caries risk factors in cleft lip/palate children. (21309653)
2012
25
Prevalence of dental caries in a nigerian rural community: a preliminary local survey. (23209974)
2011
26
Antibiotic resistance and adhesion properties of oral Enterococci associated to dental caries. (21714920)
2011
27
Use of dietary fluoride supplements by children living in Berlin, Germany, may have a dose-response preventive effect against dental caries, regardless of their use of fluoridated salt. (21605842)
2011
28
The Monitor Practice Programme: is non-invasive management of dental caries in private practice cost-effective? (21332740)
2011
29
Is there a correlation between dental caries and body mass index-for-age among adolescents in Iran? (21780359)
2011
30
Association of age specific body mass index, dental caries and socioeconomic status of children and adolescents. (22524080)
2011
31
Profiling of dental plaque microflora on root caries lesions and the protein-denaturing activity of these bacteria. (22165457)
2011
32
Does regional socioeconomic context affect the dental caries experience? A multilevel study of Korean adults. (21726290)
2011
33
Changes in dental caries in Zurich school-children over a period of 45 years. (21243546)
2010
34
Dental caries profile in Monte Negro, Amazonian state of RondA'nia, Brazil, in 2008. (21085797)
2010
35
Dental caries in children: a comparison of one non-fluoridated and two fluoridated communities in NSW. (21426851)
2010
36
Hospital based emergency department visits attributed to dental caries in the United States in 2006. (21093802)
2010
37
Molluscum contagiosum and dental caries: a pertinent combination. (19915268)
2009
38
Dental caries and gingivitis among 15 to 19 year-old students in Manaus, AM, Brazil. (19893958)
2009
39
Dental fluorosis, caries experience and snack intake of 13-15 year olds in Kenya. (19702099)
2009
40
Tuftelin, mutans streptococci, and dental caries susceptibility. (16040727)
2005
41
Root caries prevalence in a group of Brazilian adult dental patients. (15057388)
2003
42
Oral cleanliness, gingivitis, dental caries and oral health behaviours in Jordanian children. (12670081)
2002
43
Relationship among mutans streptococci, "low-pH" bacteria, and lodophilic polysaccharide-producing bacteria in dental plaque and early enamel caries in humans. (10728980)
2000
44
The pH of dental plaque in its relation to early enamel caries and dental plaque flora in humans. (10728979)
2000
45
Hydrophobic interaction chromatography and capillary zone electrophoresis to explore the correlation between the isoenzymes of salivary alpha-amylase and dental caries. (10219681)
1999
46
Dental caries and dental fluorosis among schoolchildren who were lifelong residents of communities having either low or optimal levels of fluoride in drinking water. (9608443)
1998
47
Dental caries and dental fluorosis among 4-, 6-, 12- and 15-year-old children in kindergartens and public schools in Kuwait. (8634898)
1996
48
Clinical and historical predictors of dental caries on radiographs. (9515383)
1995
49
Prevalence of dental caries and dental fluorosis in students, 11-17 years of age, in fluoridated and non-fluoridated cities in Quebec. (2276168)
1990
50
Caries and dental fluorosis in high-fluoride districts under sub-tropical conditions. (6943212)
1980

Genetic Variations for Dental Caries

Expression for genes affiliated with Dental Caries

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dental Caries

Search GEO for disease gene expression data for Dental Caries.

Pathways for genes affiliated with Dental Caries

Compounds for genes affiliated with Dental Caries

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Dental Caries according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1cysteine4511.0CST1, CSN1S1, DSPP, OXA1L, LTF, CD79A
2h2o24511.0MMP8, CD79A, LTF, OXA1L, DSPP, CSN1S1
3hydroxyapatite4511.0DSPP, PRAP1, DMP1, HTN1, CSN1S1
4fibrinogen4511.0CSN1S1, OXA1L, LTF, CD79A, MMP8
5pmma4511.0DSPP, OXA1L, LTF, CD79A
6doxycycline45 1112.0DSPP, LTF, CD79A, MMP8
7glutaraldehyde4511.0CD79A, OXA1L, DSPP, CSN1S1
8citrate4511.0CD79A, LTF, DSPP, CSN1S1
9pge24511.0CSN1S1, NR5A2, LTF, CD79A, MMP8
10tannins4511.0OXA1L, DSPP, CSN1S1
11fluoride4510.9CSN1S1, DSPP, CD79A
12exorphins4510.9CSN1S1, LTF
13diazepam45 50 29 1113.9LTF, OXA1L, CSN1S1
14citric acid45 29 11 2413.9LTF, DSPP, CSN1S1
15chlorhexidine2 45 1112.9LTF, DSPP
16vitamin b124510.9CD79A, LTF, CSN1S1
17ascorbic acid45 2411.9CSN1S1, DSPP, LTF, CD79A
18nitrilotriacetic acid45 1111.9LTF, OXA1L
19salicylic acid45 2911.9CSN1S1, DSPP, OXA1L
20polyacrylic acid4510.9CSN1S1, DSPP
21tween 804510.9OXA1L, CSN1S1
22ctab4510.9OXA1L, DSPP
23hypothiocyanite45 2411.9CD79A, LTF
24gluten4510.9CD79A, CSN1S1
25lactulose4510.9LTF, CD79A
26vitamin d4510.8CD79A, DSPP, DMP1, CSN1S1
27deae4510.8CSN1S1, OXA1L
28phenolphthalein45 1111.8OXA1L, LTF
29trichloroacetic acid4510.8DSPP, CSN1S1
30polyethylene glycol4510.8CSN1S1, OXA1L, CD79A
31chloramine t4510.8OXA1L, DSPP
32thiocyanate45 2411.8LTF, CD79A
33pneumococcal4510.8LTF, CD79A
34amoxicillin45 50 1112.8DSPP, LTF
35sodium dodecylsulfate4510.8CD79A, OXA1L, CSN1S1
36tartrate4510.7OXA1L, DSPP
37chloroform4510.7DSPP, OXA1L
38sodium fluoride4510.7CSN1S1, DSPP
39metronidazole45 1111.6LTF, DSPP
40N-Acetyl-D-glucosamine11 2411.6LYZL2, LYZ
41piroxicam45 1111.5OXA1L, CD79A
42whey4510.5LTF, CSN1S1
43cacl24510.4CSN1S1, MMP8
44gliadin4510.2CD79A, CSN1S1

GO Terms for genes affiliated with Dental Caries

Sources:
16Gene Ontology
See all sources

Cellular components related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.6MMP8, DSPP, OMD, DMP1
2extracellular regionGO:00557610.3LYZL2, CST1, CSN1S1, HTN1, PROL1, PRAP1

Biological processes related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1biomineral tissue developmentGO:03121410.5DSPP, DMP1, HTN1
2cell wall macromolecule catabolic processGO:01699810.5LYZL2, LYZ
3ossificationGO:00150310.4DMP1, DSPP, LTF
4defense response to bacteriumGO:04274210.2LYZ, LTF, HTN1

Molecular functions related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysozyme activityGO:00379610.5LYZL2, LYZ

Products for genes affiliated with Dental Caries

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dental Caries

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet