MCID: DNT012
MIFTS: 48

Dental Caries malady

Gastrointestinal diseases, Oral diseases categories
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Summaries for Dental Caries

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65Wikipedia, 33MalaCards
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Wikipedia:65 Dental caries (Latin, \"rot\"), also known as tooth decay or a cavity, is an infection, bacterial in... more...

MalaCards: Dental Caries, also known as dental caries extending into pulp, is related to dental fluorosis and periodontitis. An important gene associated with Dental Caries is DSPP (dentin sialophosphoprotein), and among its related pathways are Selected targets of C EBPalpha and Selected targets of ESR1. The compounds chlorhexidine and hypothiocyanite have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone marrow and bone.

Aliases & Classifications for Dental Caries

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

dental caries 8 10 45
dental caries extending into pulp 8
dental caries of smooth surface 8
dental caries pit and fissure 8
caries 62


External Ids:

Disease Ontology8 DOID:216
ICD9CM27 521.00, 521.0
NCIt40 C52593
MeSH35 D003731
ICD1025 K02

Related Diseases for Dental Caries

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dental Caries via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1dental fluorosis31.4AMELX
2periodontitis31.2LTF, MMP8
3periodontal disease31.0LTF, CD79A
4root caries30.9DSPP
5gingivitis30.8LTF, MMP8, DSPP
6diabetes mellitus30.5CSN1S1, CD79A, OXA1L
7asthma30.5CSN1S1, CD79A, OXA1L, MMP8
8aggressive periodontitis30.3LTF, MMP8
9arthritis30.2CSN1S1, MMP8, LTF
10rheumatoid arthritis30.0DSPP, LTF, CD79A, CSN1S1, OXA1L, MMP8
11obesity10.7
12enamel caries10.3
13dentin caries10.3
14type 1 diabetes mellitus10.3
15cerebritis10.3
16cerebral palsy10.3
17cystic fibrosis10.2
18odontoclasia10.2
19down syndrome10.2
20hemangioma10.2
21periapical periodontitis10.2
22tooth disease10.2
23urethritis10.1CD79A
24reactive arthritis10.1CD79A
25cryptosporidiosis10.1CD79A
26keratoconjunctivitis sicca10.1LTF
27gastroenteritis10.1CD79A
28hyperthyroxinemia10.1OXA1L
29attention deficit hyperactivity disorder10.1
30graft versus host disease10.1
31molluscum contagiosum10.1
32cleft lip10.1
33pulpitis10.1
34renal tubular acidosis10.1
35atherosclerosis10.1
36endocarditis10.1
37epidermolysis bullosa10.1
38hyperglycemia10.1
39intellectual disability10.1
40protein-energy malnutrition10.1
41psoriasis10.1
42schizophrenia10.1
4318p deletion syndrome10.1
44benjamin syndrome10.1
45atp6v0a2-related cutis laxa10.1
46chromosome 18p deletion syndrome10.1
47cockayne syndrome type i10.1
48exercise induced anaphylaxis10.1
49generalized dominant dystrophic epidermolysis bullosa10.1
50osteopetrosis autosomal recessive 110.1

Graphical network of the top 20 diseases related to Dental Caries:



Diseases related to dental caries

Symptoms for Dental Caries

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Drugs & Therapeutics for Dental Caries

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Dental Caries

Search NIH Clinical Center for Dental Caries

Genetic Tests for Dental Caries

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Anatomical Context for Dental Caries

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33MalaCards
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MalaCards organs/tissues related to Dental Caries:

33
Salivary gland, Bone marrow, Bone, Colon, Testes

Animal Models for Dental Caries or affiliated genes

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Publications for Dental Caries

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Sources:
52PubMed
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Articles related to Dental Caries:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Fluoride and dental caries prevention in children. (24385561)
2014
2
Total antioxidant capacity of saliva and dental caries. (23524431)
2013
3
Influence of feeding practices on dental caries. A case-control study. (23597222)
2013
4
Antimicrobial activity of fractions and subfractions of Elaeagia utilis against microorganisms of importance in dental caries. (24303734)
2013
5
Association signals unveiled by a comprehensive gene set enrichment analysis of dental caries genome-wide association studies. (23967329)
2013
6
Dental caries experience and barriers to care in young children with disabilities in Ireland. (23444182)
2013
7
Dental caries and chemical analyses in reconstruction of diet, health and hygienic behaviour in the Middle Euphrates valley (Syria). (23352446)
2013
8
Relationship between dental caries status and anemia in children with severe early childhood caries. (23684139)
2013
9
Dental caries vaccine - a possible option? (23905153)
2013
10
Antibacterial agents in composite restorations for the prevention of dental caries. (24343855)
2013
11
Innovative interventions to promote positive dental health behaviors and prevent dental caries in preschool children: study protocol for a randomized controlled trial. (23782918)
2013
12
Dentists who participate in a practice-based research network may adopt less invasive approaches to treating dental caries. (24237740)
2013
13
Dental caries and oral health practice among 12 year old school children from low socio-economic status background in Zimbabwe. (23819006)
2013
14
Management of dental caries and esthetic issues in the pediatric patient. (24073501)
2013
15
Dental caries prevalence, oral health knowledge and practice among indigenous Chepang school children of Nepal. (23672487)
2013
16
Pulpal involvement-roots-sepsis index: a new method for describing the clinical consequences of untreated dental caries. (23949116)
2013
17
Salivary proteins as a biomarker for dental caries--a systematic review. (23142096)
2013
18
Nonfluoride caries preventive agents show varied effectiveness in preventing dental caries. (22726784)
2012
19
Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis. (23091642)
2012
20
Cost-effectiveness models for dental caries prevention programmes among Chilean schoolchildren. (23488214)
2012
21
MMP13 polymorphism decreases risk for dental caries. (22710194)
2012
22
Fluorosis and dental caries: an assessment of risk factors in Mexican children. (22690531)
2012
23
Exploring the relation between body mass index, diet, and dental caries among 6-12-year-old children. (23514680)
2012
24
Effect of inhaled medication and inhalation technique on dental caries in asthmatic patients. (23483765)
2012
25
Decline in dental caries among 12-year-old children in Brazil, 1980-2005. (23252588)
2012
26
Preventing dental caries in children: Indian scenario. (22971868)
2012
27
Alloxan-induced hyperglycemia causes rapid-onset and progressive dental caries and periodontitis in F344 rats. (22936448)
2012
28
Dental Caries in the Primary Dentition of German Children With Cleft Lip and Palate. (23237430)
2012
29
The natural history of dental caries lesions: a 4-year observational study. (22821238)
2012
30
Inter-relationship of intelligence-quotient and self-concept with dental caries amongst socially handicapped orphan children. (22918097)
2012
31
Antibacterial photodynamic therapy for dental caries: evaluation of the photosensitizers used and light source properties. (22594982)
2012
32
Monitoring time-related trends in dental caries in permanent teeth in Japanese national surveys. (22420480)
2012
33
Asthma and dental caries. (22722409)
2012
34
Assessment of dental caries risk in children based on color Doppler US and the changes in blood perfusion in the salivary glands during salivary stimulation. (21918953)
2012
35
Development of an auxiliary resource for diagnosis of dental caries in epidemiological surveys. (21689374)
2011
36
Dental caries trends in Australian school children. (21770083)
2011
37
Oral health among white, black, and Mexican-American elders: an examination of edentulism and dental caries. (22320289)
2011
38
New directions in the etiology of dental caries disease. (22132583)
2011
39
Association between occlusal anomalies and dental caries in 3- to 5 year-old Brazilian children. (21367823)
2011
40
Dental caries in rats associated with Candida albicans. (21412001)
2011
41
The incidence of dental caries in children and adolescents who have cerebral palsy and are participating in a dental program in Brazil. (22070360)
2011
42
Changes in dental caries in Zurich school-children over a period of 45 years. (21243546)
2010
43
Dental caries as a side effect of infantile hemangioma treatment with propranolol solution. (21510011)
2010
44
Dental caries profile in Monte Negro, Amazonian state of RondA'nia, Brazil, in 2008. (21085797)
2010
45
Dental caries experience among young Australian adults. (21174922)
2010
46
Oral health status, dental caries risk factors of the children of public kindergarten and schools in Phranakornsriayudhya, Thailand. (21284137)
2010
47
Considerations on optimal fluoride intake using dental fluorosis and dental caries outcomes--a longitudinal study. (19054310)
2009
48
Molluscum contagiosum and dental caries: a pertinent combination. (19915268)
2009
49
Hydrophobic interaction chromatography and capillary zone electrophoresis to explore the correlation between the isoenzymes of salivary alpha-amylase and dental caries. (10219681)
1999
50
Dental caries and dental fluorosis. (3226636)
1988

Variations for Dental Caries

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Expression for genes affiliated with Dental Caries

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dental Caries

Search GEO for disease gene expression data for Dental Caries.

Pathways for genes affiliated with Dental Caries

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50PathCards, 12EMD Millipore
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Pathways related to Dental Caries according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8LTF, MMP8
29.6LTF, NR5A2

Compounds for genes affiliated with Dental Caries

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Sources:
45Novoseek, 3BitterDB, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR
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Compounds related to Dental Caries according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1chlorhexidine45 3 1112.3DSPP, LTF
2hypothiocyanite45 2411.2CD79A, LTF
3lactulose4510.2CD79A, LTF
4thiocyanate45 2411.1CD79A, LTF
5pneumococcal4510.1LTF, CD79A
6amoxicillin45 51 1112.1LTF, DSPP
7metronidazole45 1111.0DSPP, LTF
8polyacrylic acid4510.0DSPP, CSN1S1
9exorphins459.9CSN1S1, LTF
10gluten459.9CD79A, CSN1S1
11trichloroacetic acid459.9DSPP, CSN1S1
12sodium fluoride459.8CSN1S1, DSPP
13ctab459.7DSPP, OXA1L
14nitrilotriacetic acid45 1110.7OXA1L, LTF
15fluoride459.7DSPP, CD79A, CSN1S1
16chloramine t459.7DSPP, OXA1L
17doxycycline45 1110.7CD79A, DSPP, MMP8, LTF
18citric acid45 29 24 1112.6DSPP, LTF, CSN1S1
19cacl2459.6CSN1S1, MMP8
20phenolphthalein45 1110.6LTF, OXA1L
21vitamin b12459.6CD79A, CSN1S1, LTF
22tartrate459.6OXA1L, DSPP
23chloroform459.5OXA1L, DSPP
24formaldehyde45 2410.5CSN1S1, DSPP, CD79A
25carbohydrates459.5LTF, CSN1S1, DSPP
26gliadin459.5CSN1S1, CD79A
27piroxicam45 1110.4OXA1L, CD79A
28tween 80459.4OXA1L, CSN1S1
29deae459.4CSN1S1, OXA1L
30citrate459.4DSPP, CSN1S1, LTF, CD79A
31ascorbic acid45 2410.3CD79A, DSPP, LTF, CSN1S1
32lactate459.3CD79A, CSN1S1, MMP8, DSPP
33glycerol45 24 1111.3CD79A, CSN1S1, DSPP
34whey459.2LTF, CSN1S1
35phosphatidylcholine459.2CSN1S1, CD79A, LTF
36tannins459.2CSN1S1, OXA1L, DSPP
37pmma459.2OXA1L, DSPP, CD79A, LTF
38salicylic acid45 2910.2OXA1L, CSN1S1, DSPP
39polyethylene glycol459.1OXA1L, CD79A, CSN1S1
40diazepam45 29 51 1112.1OXA1L, CSN1S1, LTF
41sodium dodecylsulfate459.1CD79A, OXA1L, CSN1S1
42alanine459.0MMP8, LTF, CD79A, CSN1S1, DSPP
43thyroxine45 2410.0CD79A, CSN1S1, OXA1L
44glutaraldehyde458.9OXA1L, DSPP, CD79A, CSN1S1
45pge2458.8CD79A, NR5A2, CSN1S1, LTF, MMP8
46estrogen458.8CSN1S1, CD79A, LTF, DSPP, NR5A2
47retinoic acid45 249.7CSN1S1, LTF, CD79A, MMP8, NR5A2
48fibrinogen458.5LTF, MMP8, CD79A, CSN1S1, OXA1L
49h2o2458.2CD79A, DSPP, MMP8, LTF, CSN1S1, OXA1L
50cysteine458.2DSPP, MMP8, OXA1L, LTF, CD79A, CSN1S1

GO Terms for genes affiliated with Dental Caries

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16Gene Ontology
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Cellular components related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.5MMP8, DSPP, AMELX

Biological processes related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ossificationGO:0015039.8LTF, DSPP
2biomineral tissue developmentGO:0312149.7DSPP, AMELX
3odontogenesis of dentin-containing toothGO:0424759.4NKX2-3, AMELX

Products for genes affiliated with Dental Caries

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dental Caries

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet