MCID: DNT012
MIFTS: 51

Dental Caries malady

Gastrointestinal diseases category

Summaries for Dental Caries

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63Wikipedia, 32MalaCards
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Wikipedia:63 Dental caries (Latin, \"rot\"), also known as tooth decay or a cavity, is an infection, bacterial in... more...

MalaCards: Dental Caries, also known as dental caries extending into pulp, is related to periodontitis and periodontal disease. An important gene associated with Dental Caries is DSPP (dentin sialophosphoprotein). The compounds cysteine and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, testes and bone.

Aliases & Classifications for Dental Caries

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

dental caries 8 10 44
dental caries extending into pulp 8
dental caries of smooth surface 8
dental caries pit and fissure 8
caries 60


External Ids:

Disease Ontology8 DOID:216
ICD9CM27 521.00, 521.0
NCIt39 C52593
MeSH34 D003731
ICD1025 K02

Related Diseases for Dental Caries

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dental Caries via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.0MMP8
2periodontal disease30.8LTF, MMP8, DSPP, CD79A
3root caries30.7DSPP
4gingivitis30.6LTF, MMP8, DSPP
5diabetes mellitus30.4CD79A, CSN1S1, OXA1L
6protein-energy malnutrition30.0CSN1S1
7aggressive periodontitis30.0MMP8, LTF
8arthritis30.0LTF, LYZ, CSN1S1, MMP8
9lactose intolerance29.7CSN1S1, LTF
10peritonitis29.7MMP8
11dental fluorosis10.9
12obesity10.6
13enamel caries10.6
14dentin caries10.5
15asthma10.3
16cerebritis10.3
17type 1 diabetes mellitus10.3
18down syndrome10.3
19cerebral palsy10.3
20tooth disease10.3
21curly hair-acral keratoderma-caries syndrome10.2
22graft versus host disease10.2
23cystic fibrosis10.2
24cleft lip10.2
25odontoclasia10.2
26cleft palate10.2
27endocarditis10.2
28hemangioma10.2
29periapical periodontitis10.2
30attention deficit hyperactivity disorder10.0
31molluscum contagiosum10.0
32pulpitis10.0
33subacute bacterial endocarditis10.0
34renal tubular acidosis10.0
35atherosclerosis10.0
36epidermolysis bullosa10.0
37gingival disease10.0
38hyperglycemia10.0
39intellectual disability10.0
40kidney disease10.0
41psoriasis10.0
42rheumatoid arthritis10.0
43schizophrenia10.0
4418p deletion syndrome10.0
45benjamin syndrome10.0
46cutis laxa, autosomal recessive type 2a10.0
47osteopetrosis autosomal recessive 110.0
48cockayne syndrome type i10.0
49generalized dominant dystrophic epidermolysis bullosa10.0
50tricho-dento-osseous syndrome 110.0

Graphical network of the top 20 diseases related to Dental Caries:



Diseases related to dental caries

Clinical Features for Dental Caries

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Drugs & Therapeutics for Dental Caries

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dental Caries

Drug clinical trials:

Search ClinicalTrials for Dental Caries

Search NIH Clinical Center for Dental Caries

Search CenterWatch for Dental Caries

Genetic Tests for Dental Caries

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Anatomical Context for Dental Caries

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Sources:
32MalaCards
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MalaCards organs/tissues related to Dental Caries:

32
Salivary gland, Testes, Bone, Kidney, Bone marrow, Colon

Animal Models for Dental Caries or affiliated genes

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Publications for Dental Caries

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Sources:
50PubMed
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Articles related to Dental Caries:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
Systemic effect of water fluoridation on dental caries prevalence. (24428350)
2014
2
Dental caries experience and barriers to care in young children with disabilities in Ireland. (23444182)
2013
3
Dental caries prevalence, oral health knowledge and practice among indigenous Chepang school children of Nepal. (23672487)
2013
4
Association between dental caries and obesity in preschool children. (24295001)
2013
5
Evaluation of an oral health promotion program at the time of birth on dental caries in 5-year-old children in Vorarlberg, Austria. (24033742)
2013
6
Clinical and biological indicators of dental caries and periodontal disease in adolescents with or without obesity. (23515945)
2013
7
The role of family functioning in childhood dental caries. (24117838)
2013
8
Prevalence, severity and associated factors of dental caries in 3-6 year old children. (24086915)
2013
9
Nanotechnology-based restorative materials for dental caries management. (23810638)
2013
10
Prevalence of dental caries and treatment needs in children in coastal areas of West Bengal. (24403793)
2013
11
Dental caries: An updated medical model of risk assessment. (24331852)
2013
12
Oral hygiene and dental caries in 5- to 6-year-old children in Ajman, United Arab Emirates. (23216907)
2013
13
Effect of dental treatments on salivary immunoglobulin A of children with and without dental caries: a comparative study. (24025894)
2013
14
Salivary trace elements in relation to dental caries in a group of multi-ethnic schoolchildren in Shah Alam, Malaysia. (23758460)
2013
15
Milk fluoridation for the prevention of dental caries. (24308395)
2013
16
Use of laser fluorescence in dental caries diagnosis: a fluorescence x biomolecular vibrational spectroscopic comparative study. (23657415)
2013
17
A cross-sectional survey of dental caries, oral hygiene, and Helicobacter pylori infection in adults. (23966603)
2013
18
Dental Caries and Vaccination Strategy Against the Major Cariogenic Pathogen, Streptococcus Mutans. (24372246)
2013
19
Nonfluoride caries preventive agents show varied effectiveness in preventing dental caries. (22726784)
2012
20
Effect of inhaled medication and inhalation technique on dental caries in asthmatic patients. (23483765)
2012
21
Antimicrobial potential of extracts from Stevia rebaudiana leaves against bacteria of importance in dental caries. (23230637)
2012
22
Molecular approaches for viable bacterial population and transcriptional analyses in a rodent model of dental caries. (22958384)
2012
23
Dental caries and oral health practices among 12 year old children in Nairobi West and Mathira West Districts, Kenya. (22891100)
2012
24
Dental caries in Mexican schoolchildren: a comparison of 1988-1989 and 1998-2001 surveys. (22549683)
2012
25
Dental caries and total antioxidant status of unstimulated mixed whole saliva in patients aged 16-23 years. (22472470)
2012
26
Oral diagnosis and treatment planning: part 5. Preventive and treatment planning for dental caries. (22955757)
2012
27
Periodontal disease and dental caries from Krapina Neanderthal to contemporary man - skeletal studies. (23331387)
2012
28
Strategic protein target analysis for developing drugs to stop dental caries. (22899687)
2012
29
Post-brushing rinsing for the control of dental caries: exploration of the available evidence to establish what advice we should give our patients. (22498529)
2012
30
Influence of maternal dental anxiety on the child's dental caries experience. (22156724)
2012
31
Amounts of Sr and Ca eluted from deciduous enamel to artificial saliva related to dental caries. (22391794)
2012
32
Dental caries trends in Australian school children. (21770083)
2011
33
Oral health among white, black, and Mexican-American elders: an examination of edentulism and dental caries. (22320289)
2011
34
Clustering of obesity and dental caries with lifestyle factors among Danish adolescents. (21842014)
2011
35
A review of the role of solar ultraviolet-B irradiance and vitamin D in reducing risk of dental caries. (22110779)
2011
36
Association between asthma and dental caries in the primary dentition of Mexican children. (21633854)
2011
37
Dental caries and the nutritional status of preschool children: a spatial analysis. (22031145)
2011
38
Prevalence of dental caries and its correlation with the immunologic profile in HIV-Infected children on antiretroviral therapy. (21668277)
2011
39
Association between anthropometric measurements and dental caries in Turkish school children. (22026291)
2011
40
Relation of salivary calcium, phosphorus and alkaline phosphatase with the incidence of dental caries in children. (21157046)
2010
41
Relationship of dental caries at different concentrations of fluoride in endemic areas: an epidemiological study. (21189763)
2010
42
Dental caries, gingivitis and the treatment needs among 12-year-olds. (23057300)
2010
43
Apgar score and dental caries risk in the primary dentition of five year olds. (20887512)
2010
44
Systematic reviews of topical fluorides for dental caries: a review of reporting practice. (21150202)
2010
45
A case-control study of determinants for high and low dental caries prevalence in Nevada youth. (21067620)
2010
46
Aluminum concentrations in human deciduous enamel and dentin related to dental caries. (15646261)
2004
47
The 48-month increment of root caries in an urban population of older adults participating in a preventive dental program. (8371190)
1993
48
Trends in dental fluorosis and dental caries prevalences in Newburgh and Kingston, NY. (2705588)
1989
49
A comparison of identical twins in relation to three dental anomalies: multiple supernumerary teeth, juvenile periodontosis, and zero caries incidence. (6946362)
1981
50
Hypothetical protocol: epidemiological survey title: an epidemiologic study of dental caries and dental fluorosis. (6930401)
1980

Genetic Variations for Dental Caries

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Expression for genes affiliated with Dental Caries

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dental Caries

Search GEO for disease gene expression data for Dental Caries.

Pathways for genes affiliated with Dental Caries

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Compounds for genes affiliated with Dental Caries

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Dental Caries according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1cysteine4411.0CST1, CSN1S1, DSPP, OXA1L, LTF, CD79A
2h2o24411.0MMP8, CD79A, LTF, OXA1L, DSPP, CSN1S1
3hydroxyapatite4411.0DSPP, PRAP1, DMP1, HTN1, CSN1S1
4fibrinogen4411.0CSN1S1, OXA1L, LTF, CD79A, MMP8
5pmma4411.0DSPP, OXA1L, LTF, CD79A
6doxycycline44 1112.0DSPP, LTF, CD79A, MMP8
7glutaraldehyde4411.0CD79A, OXA1L, DSPP, CSN1S1
8citrate4411.0CD79A, LTF, DSPP, CSN1S1
9pge24411.0CSN1S1, NR5A2, LTF, CD79A, MMP8
10tannins4411.0OXA1L, DSPP, CSN1S1
11fluoride4410.9CSN1S1, DSPP, CD79A
12exorphins4410.9CSN1S1, LTF
13diazepam44 49 28 1113.9LTF, OXA1L, CSN1S1
14citric acid44 28 11 2413.9LTF, DSPP, CSN1S1
15chlorhexidine2 44 1112.9LTF, DSPP
16vitamin b124410.9CD79A, LTF, CSN1S1
17ascorbic acid44 2411.9CSN1S1, DSPP, LTF, CD79A
18nitrilotriacetic acid44 1111.9LTF, OXA1L
19salicylic acid44 2811.9CSN1S1, DSPP, OXA1L
20polyacrylic acid4410.9CSN1S1, DSPP
21tween 804410.9OXA1L, CSN1S1
22ctab4410.9OXA1L, DSPP
23hypothiocyanite44 2411.9CD79A, LTF
24gluten4410.9CD79A, CSN1S1
25lactulose4410.9LTF, CD79A
26vitamin d4410.8CD79A, DSPP, DMP1, CSN1S1
27deae4410.8CSN1S1, OXA1L
28phenolphthalein44 1111.8OXA1L, LTF
29trichloroacetic acid4410.8DSPP, CSN1S1
30polyethylene glycol4410.8CSN1S1, OXA1L, CD79A
31chloramine t4410.8OXA1L, DSPP
32thiocyanate44 2411.8LTF, CD79A
33pneumococcal4410.8LTF, CD79A
34amoxicillin44 49 1112.8DSPP, LTF
35sodium dodecylsulfate4410.8CD79A, OXA1L, CSN1S1
36tartrate4410.7OXA1L, DSPP
37chloroform4410.7DSPP, OXA1L
38sodium fluoride4410.7CSN1S1, DSPP
39metronidazole44 1111.6LTF, DSPP
40N-Acetyl-D-glucosamine11 2411.6LYZL2, LYZ
41piroxicam44 1111.5OXA1L, CD79A
42whey4410.5LTF, CSN1S1
43cacl24410.4CSN1S1, MMP8
44gliadin4410.2CD79A, CSN1S1

GO Terms for genes affiliated with Dental Caries

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16Gene Ontology
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Cellular components related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.6MMP8, DSPP, OMD, DMP1
2extracellular regionGO:00557610.3LYZL2, CST1, CSN1S1, HTN1, PROL1, PRAP1

Biological processes related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1biomineral tissue developmentGO:03121410.5DSPP, DMP1, HTN1
2cell wall macromolecule catabolic processGO:01699810.5LYZL2, LYZ
3ossificationGO:00150310.4DMP1, DSPP, LTF
4defense response to bacteriumGO:04274210.2LYZ, LTF, HTN1

Molecular functions related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysozyme activityGO:00379610.5LYZL2, LYZ

Products for genes affiliated with Dental Caries

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dental Caries

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet