MCID: DNT012
MIFTS: 51

Dental Caries malady

Gastrointestinal diseases category

Summaries for Dental Caries

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63Wikipedia, 32MalaCards
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Wikipedia:63 Dental caries (Latin, \"rot\"), also known as tooth decay or a cavity, is an infection, bacterial in... more...

MalaCards: Dental Caries, also known as dental caries extending into pulp, is related to periodontitis and periodontal disease. An important gene associated with Dental Caries is DSPP (dentin sialophosphoprotein). The compounds cysteine and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone marrow and bone.

Aliases & Classifications for Dental Caries

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

dental caries 8 10 44
dental caries extending into pulp 8
dental caries of smooth surface 8
dental caries pit and fissure 8
caries 60


External Ids:

Disease Ontology8 DOID:216
ICD9CM27 521.00, 521.0
NCIt39 C52593
MeSH34 D003731
ICD1025 K02

Related Diseases for Dental Caries

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dental Caries via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.0MMP8
2periodontal disease30.8LTF, MMP8, DSPP, CD79A
3root caries30.7DSPP
4gingivitis30.6LTF, MMP8, DSPP
5diabetes mellitus30.4CD79A, CSN1S1, OXA1L
6protein-energy malnutrition30.0CSN1S1
7aggressive periodontitis30.0MMP8, LTF
8arthritis30.0LTF, LYZ, CSN1S1, MMP8
9lactose intolerance29.7CSN1S1, LTF
10peritonitis29.7MMP8
11dental fluorosis10.9
12obesity10.6
13enamel caries10.6
14dentin caries10.5
15asthma10.3
16cerebritis10.3
17type 1 diabetes mellitus10.3
18down syndrome10.3
19cerebral palsy10.3
20tooth disease10.3
21curly hair-acral keratoderma-caries syndrome10.2
22graft versus host disease10.2
23cystic fibrosis10.2
24cleft lip10.2
25odontoclasia10.2
26cleft palate10.2
27endocarditis10.2
28hemangioma10.2
29periapical periodontitis10.2
30attention deficit hyperactivity disorder10.0
31molluscum contagiosum10.0
32pulpitis10.0
33subacute bacterial endocarditis10.0
34renal tubular acidosis10.0
35atherosclerosis10.0
36epidermolysis bullosa10.0
37gingival disease10.0
38hyperglycemia10.0
39intellectual disability10.0
40kidney disease10.0
41psoriasis10.0
42rheumatoid arthritis10.0
43schizophrenia10.0
4418p deletion syndrome10.0
45benjamin syndrome10.0
46cutis laxa, autosomal recessive type 2a10.0
47osteopetrosis autosomal recessive 110.0
48cockayne syndrome type i10.0
49generalized dominant dystrophic epidermolysis bullosa10.0
50tricho-dento-osseous syndrome 110.0

Graphical network of the top 20 diseases related to Dental Caries:



Diseases related to dental caries

Clinical Features for Dental Caries

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Drugs & Therapeutics for Dental Caries

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dental Caries

Drug clinical trials:

Search ClinicalTrials for Dental Caries

Search NIH Clinical Center for Dental Caries

Search CenterWatch for Dental Caries

Genetic Tests for Dental Caries

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Anatomical Context for Dental Caries

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Sources:
32MalaCards
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MalaCards organs/tissues related to Dental Caries:

32
Salivary gland, Bone marrow, Bone, Colon, Kidney, Testes

Animal Models for Dental Caries or affiliated genes

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Publications for Dental Caries

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Sources:
50PubMed
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Articles related to Dental Caries:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
Fluoride and dental caries prevention in children. (24385561)
2014
2
Dental caries vaccine - a possible option? (23905153)
2013
3
Antibacterial agents in composite restorations for the prevention of dental caries. (24343855)
2013
4
Prevalence and polarization of dental caries among young, healthy adults: Cross-sectional epidemiological study. (23627898)
2013
5
Dental caries prevalence in children and adolescents with cystic fibrosis: a qualitative systematic review and recommendations for future research. (23758751)
2013
6
Common SNPs of AmelogeninX (AMELX) and dental caries susceptibility. (23525533)
2013
7
The effect of eugenol on the cariogenic properties of Streptococcus mutans and dental caries development in rats. (23837051)
2013
8
Association between dental caries and age-specific body mass index in preschool children of an Iranian population. (23852235)
2013
9
Sociodemographic, biological and behavioural risk factors associated with incidence of dental caries in schoolchildren's first permanent molars: a 3-year follow-up study. (23597212)
2013
10
Family relationships as an explanatory variable in childhood dental caries: a systematic review of measures. (24107605)
2013
11
Epidemiological analysis of dental caries in 12-year-old children residing in urban and rural settings in the Podlaskie region of north-eastern Poland. (23772585)
2013
12
Dental plaque, preventive care, and tooth brushing associated with dental caries in primary teeth in schoolchildren ages 6-9 years of Leon, Nicaragua. (24247119)
2013
13
Evaluation of physio-chemical properties of saliva and comparison of its relation with dental caries. (24262393)
2013
14
A cross sectional study of dermatoglyphics and dental caries in Bengalee children. (24262398)
2013
15
Oral health impact, dental caries, and oral health behaviors among the National Cadets Corps in South India. (22767492)
2013
16
Glycemic control with insulin prevents progression of dental caries and caries-related periodontitis in diabetic WBN/KobSlc rats. (23076036)
2013
17
Influence of family structure on dental caries experience of preschool children in Sri Lanka. (22516978)
2012
18
Association among quality of life, dental caries treatment and intraoral distribution in 12-year-old South Brazilian schoolchildren. (22882480)
2012
19
Impact of treating dental caries on schoolchildren's anthropometric, dental, satisfaction and appetite outcomes: a randomized controlled trial. (22928903)
2012
20
A systematic review of socioeconomic indicators and dental caries in adults. (23202762)
2012
21
Diagnostic accuracy of digital and conventional radiography in the detection of non-cavitated approximal dental caries. (23329955)
2012
22
Comment: low dental caries rate in Neandertals: the result of diet or the oral flora composition? (22409830)
2012
23
Religiosity, spirituality, social support, health behaviour and dental caries among 35- to 44-year-old Jerusalem adults: a proposed conceptual model. (22678495)
2012
24
Maryland dental hygienists' knowledge, opinions and practices regarding dental caries prevention and early detection. (23168104)
2012
25
The prevalence of dental caries in Missouri and its relation to systemic disease: opportunities for Missouri to improve the health of its citizens. (22953597)
2012
26
Protective effects of salivary factors in dental caries in diabetic patients of Pakistan. (22778718)
2012
27
Dental caries in Rome, 50-100 AD. (22796661)
2012
28
Association between obesity, dental caries and socioeconomic status in 6- and 13-year-old school children. (23094266)
2012
29
The evolution of dental caries treatment. (23032225)
2012
30
A histological study of peripheral dental caries of equine cheek teeth. (23193708)
2012
31
Association between occlusal anomalies and dental caries in 3- to 5 year-old Brazilian children. (21367823)
2011
32
Dental caries in rats associated with Candida albicans. (21412001)
2011
33
Factors associated with prevalence of dental caries in Brazilian schoolchildren residing in Japan. (21959657)
2011
34
The influence of visible dental caries on social judgements and overall facial attractiveness amongst undergraduates. (21211545)
2011
35
Susceptibility to dental caries and the salivary proline-rich proteins. (22190937)
2011
36
Dental caries status and salivary properties of asthmatic children and adolescents. (21281365)
2011
37
Oral health of Iranian children in 2004: a national pathfinder survey of dental caries and treatment needs. (21735966)
2011
38
Current status of dental caries diagnosis using cone beam computed tomography. (21977474)
2011
39
Dental caries in children. (20964102)
2010
40
Trends in dental caries prevalence, severity and unmet treatment need levels in South Africa between 1983 and 2002. (21133233)
2010
41
Dental caries in adolescents from public schools in Maputo, Mozambique. (20949758)
2010
42
Considerations on optimal fluoride intake using dental fluorosis and dental caries outcomes--a longitudinal study. (19054310)
2009
43
Diagnosing dental caries in populations with different levels of dental fluorosis. (19320725)
2009
44
High fluoride concentration in drinking water may increase the prevalence and severity of dental fluorosis, and decrease occurrence of caries. (18346695)
2008
45
Two-dimensional electrophoresis study of in vitro pellicle formation and dental caries susceptibility. (16630307)
2006
46
Pulp-dentin biology in restorative dentistry. Part 4: Dental caries--characteristics of lesions and pulpal reactions. (11695140)
2001
47
Changes in dental fluorosis and dental caries in Newburgh and Kingston, New York. (9842391)
1998
48
Model investigations of caries inhibition by fluoride-releasing dental materials. (8615951)
1995
49
Influence of fluoride in surface enamel and degree of dental fluorosis on caries development in vitro. (6929731)
1980
50
Comparative studies on dental caries in the school population of an area of endemic dental fluorosis and of an area with almost fluorine-free water. (5833518)
1965

Genetic Variations for Dental Caries

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Expression for genes affiliated with Dental Caries

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dental Caries

Search GEO for disease gene expression data for Dental Caries.

Pathways for genes affiliated with Dental Caries

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Compounds for genes affiliated with Dental Caries

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Dental Caries according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1cysteine4411.0CST1, CSN1S1, DSPP, OXA1L, LTF, CD79A
2h2o24411.0MMP8, CD79A, LTF, OXA1L, DSPP, CSN1S1
3hydroxyapatite4411.0DSPP, PRAP1, DMP1, HTN1, CSN1S1
4fibrinogen4411.0CSN1S1, OXA1L, LTF, CD79A, MMP8
5pmma4411.0DSPP, OXA1L, LTF, CD79A
6doxycycline44 1112.0DSPP, LTF, CD79A, MMP8
7glutaraldehyde4411.0CD79A, OXA1L, DSPP, CSN1S1
8citrate4411.0CD79A, LTF, DSPP, CSN1S1
9pge24411.0CSN1S1, NR5A2, LTF, CD79A, MMP8
10tannins4411.0OXA1L, DSPP, CSN1S1
11fluoride4410.9CSN1S1, DSPP, CD79A
12exorphins4410.9CSN1S1, LTF
13diazepam44 49 28 1113.9LTF, OXA1L, CSN1S1
14citric acid44 28 11 2413.9LTF, DSPP, CSN1S1
15chlorhexidine2 44 1112.9LTF, DSPP
16vitamin b124410.9CD79A, LTF, CSN1S1
17ascorbic acid44 2411.9CSN1S1, DSPP, LTF, CD79A
18nitrilotriacetic acid44 1111.9LTF, OXA1L
19salicylic acid44 2811.9CSN1S1, DSPP, OXA1L
20polyacrylic acid4410.9CSN1S1, DSPP
21tween 804410.9OXA1L, CSN1S1
22ctab4410.9OXA1L, DSPP
23hypothiocyanite44 2411.9CD79A, LTF
24gluten4410.9CD79A, CSN1S1
25lactulose4410.9LTF, CD79A
26vitamin d4410.8CD79A, DSPP, DMP1, CSN1S1
27deae4410.8CSN1S1, OXA1L
28phenolphthalein44 1111.8OXA1L, LTF
29trichloroacetic acid4410.8DSPP, CSN1S1
30polyethylene glycol4410.8CSN1S1, OXA1L, CD79A
31chloramine t4410.8OXA1L, DSPP
32thiocyanate44 2411.8LTF, CD79A
33pneumococcal4410.8LTF, CD79A
34amoxicillin44 49 1112.8DSPP, LTF
35sodium dodecylsulfate4410.8CD79A, OXA1L, CSN1S1
36tartrate4410.7OXA1L, DSPP
37chloroform4410.7DSPP, OXA1L
38sodium fluoride4410.7CSN1S1, DSPP
39metronidazole44 1111.6LTF, DSPP
40N-Acetyl-D-glucosamine11 2411.6LYZL2, LYZ
41piroxicam44 1111.5OXA1L, CD79A
42whey4410.5LTF, CSN1S1
43cacl24410.4CSN1S1, MMP8
44gliadin4410.2CD79A, CSN1S1

GO Terms for genes affiliated with Dental Caries

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16Gene Ontology
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Cellular components related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.6MMP8, DSPP, OMD, DMP1
2extracellular regionGO:00557610.3LYZL2, CST1, CSN1S1, HTN1, PROL1, PRAP1

Biological processes related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1biomineral tissue developmentGO:03121410.5DSPP, DMP1, HTN1
2cell wall macromolecule catabolic processGO:01699810.5LYZL2, LYZ
3ossificationGO:00150310.4DMP1, DSPP, LTF
4defense response to bacteriumGO:04274210.2LYZ, LTF, HTN1

Molecular functions related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysozyme activityGO:00379610.5LYZL2, LYZ

Products for genes affiliated with Dental Caries

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dental Caries

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet