MCID: DNT012
MIFTS: 51

Dental Caries malady

Gastrointestinal diseases category

Summaries for Dental Caries

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63Wikipedia, 32MalaCards
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Wikipedia:63 Dental caries (Latin, \"rot\"), also known as tooth decay or a cavity, is an infection, bacterial in... more...

MalaCards: Dental Caries, also known as dental caries extending into pulp, is related to periodontitis and periodontal disease. An important gene associated with Dental Caries is DSPP (dentin sialophosphoprotein). The compounds cysteine and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone marrow and bone.

Aliases & Classifications for Dental Caries

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

dental caries 8 10 44
dental caries extending into pulp 8
dental caries of smooth surface 8
dental caries pit and fissure 8
caries 60


External Ids:

Disease Ontology8 DOID:216
ICD9CM27 521.00, 521.0
NCIt39 C52593
MeSH34 D003731
ICD1025 K02

Related Diseases for Dental Caries

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dental Caries via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis31.0MMP8
2periodontal disease30.8LTF, MMP8, DSPP, CD79A
3root caries30.7DSPP
4gingivitis30.6LTF, MMP8, DSPP
5diabetes mellitus30.4CD79A, CSN1S1, OXA1L
6protein-energy malnutrition30.0CSN1S1
7aggressive periodontitis30.0MMP8, LTF
8arthritis30.0LTF, LYZ, CSN1S1, MMP8
9lactose intolerance29.7CSN1S1, LTF
10peritonitis29.7MMP8
11dental fluorosis10.9
12obesity10.6
13enamel caries10.6
14dentin caries10.5
15asthma10.3
16cerebritis10.3
17type 1 diabetes mellitus10.3
18down syndrome10.3
19cerebral palsy10.3
20tooth disease10.3
21curly hair-acral keratoderma-caries syndrome10.2
22graft versus host disease10.2
23cystic fibrosis10.2
24cleft lip10.2
25odontoclasia10.2
26cleft palate10.2
27endocarditis10.2
28hemangioma10.2
29periapical periodontitis10.2
30attention deficit hyperactivity disorder10.0
31molluscum contagiosum10.0
32pulpitis10.0
33subacute bacterial endocarditis10.0
34renal tubular acidosis10.0
35atherosclerosis10.0
36epidermolysis bullosa10.0
37gingival disease10.0
38hyperglycemia10.0
39intellectual disability10.0
40kidney disease10.0
41psoriasis10.0
42rheumatoid arthritis10.0
43schizophrenia10.0
4418p deletion syndrome10.0
45benjamin syndrome10.0
46cutis laxa, autosomal recessive type 2a10.0
47osteopetrosis autosomal recessive 110.0
48cockayne syndrome type i10.0
49generalized dominant dystrophic epidermolysis bullosa10.0
50tricho-dento-osseous syndrome 110.0

Graphical network of the top 20 diseases related to Dental Caries:



Diseases related to dental caries

Clinical Features for Dental Caries

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Drugs & Therapeutics for Dental Caries

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dental Caries

Drug clinical trials:

Search ClinicalTrials for Dental Caries

Search NIH Clinical Center for Dental Caries

Search CenterWatch for Dental Caries

Genetic Tests for Dental Caries

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Anatomical Context for Dental Caries

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Sources:
32MalaCards
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MalaCards organs/tissues related to Dental Caries:

32
Salivary gland, Bone marrow, Bone, Colon, Kidney, Testes

Animal Models for Dental Caries or affiliated genes

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Publications for Dental Caries

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Sources:
50PubMed
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Articles related to Dental Caries:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
Association between Dental Caries and Adiposity Status (General, Central, and Peripheral Adiposity) in 12-Year-Old Children. (24216773)
2014
2
Total antioxidant capacity of saliva and dental caries. (23524431)
2013
3
Dental caries and oral health practice among 12 year old school children from low socio-economic status background in Zimbabwe. (23819006)
2013
4
Salivary characteristics and dental caries: evidence from general dental practices. (23633704)
2013
5
Factors associated with dental caries in Brazilian children: a multilevel approach. (24354434)
2013
6
Xylitol lozenges were not effective in overall dental caries prevention in adults. (24011003)
2013
7
Dental caries in children--an assessment of the knowledge of Nigerian paediatricians. (24377201)
2013
8
Food expenditures, cariogenic dietary practices and childhood dental caries in southern Brazil. (23571856)
2013
9
Prevalence of clinical consequences of untreated dental caries and its relation to dental fear among 12-15-year-old schoolchildren in Bangalore city, India. (23835899)
2013
10
The effects of asthma and asthma medication on dental caries and salivary characteristics in children. (23534042)
2013
11
Developmental delays and dental caries in low-income preschoolers in the USA: a pilot cross-sectional study and preliminary explanatory model. (24119240)
2013
12
Fluoride varnishes for preventing dental caries in children and adolescents. (23846772)
2013
13
Preventing dental caries associated with sugar-sweetened beverages. (24080931)
2013
14
Dental Caries and Head and Neck Cancers. (24030728)
2013
15
Analysis of health behaviour change interventions for preventing dental caries delivered in primary schools. (24107603)
2013
16
The natural history of dental caries lesions: a 4-year observational study. (22821238)
2012
17
Monitoring time-related trends in dental caries in permanent teeth in Japanese national surveys. (22420480)
2012
18
Asthma and dental caries. (22722409)
2012
19
Dental fluorosis, dental caries, and quality of life factors among schoolchildren in a Colombian fluorotic area. (22482258)
2012
20
Dental caries and dental fluorosis in children on the NSW Central Coast: a cross-sectional study of fluoridated and non-fluoridated areas. (22672044)
2012
21
Quantitative detection of Streptococcus mutans and bacteria of dental caries and no caries groups in permanent teeth from a north China population. (23106892)
2012
22
Interdental spacing and dental caries in the primary dentition of 4-6 year old children. (23119129)
2012
23
Dental caries experience among 12-year-old children in Northwest Russia. (22482244)
2012
24
Association between infant formula feeding and dental fluorosis and caries in Australian children. (22315949)
2012
25
Community-oriented administration of fluoride for the prevention of dental caries: a summary of the current situation in Asia. (22261256)
2012
26
Tooth loss and dental caries in community-dwelling older adults in northern Manhattan. (21718349)
2012
27
Assessment of dental caries predictors in 6-year-old school children - results from 5-year retrospective cohort study. (23158416)
2012
28
Infectious endocarditis caused by Lactobacillus acidophilus in a patient with mistreated dental caries. (22728502)
2012
29
Dental Caries, and Supragingival Plaque and Calculus among Students, Tanga, Tanzania. (22461985)
2012
30
Dental caries recurrence following clinical treatment for severe early childhood caries. (22353412)
2011
31
Prevalence of sealants in relation to dental caries on the permanent molars of 12 and 15-year-old Greek adolescents. A national pathfinder survey. (21320343)
2011
32
Oral health knowledge, practice, oral hygiene status, and dental caries prevalence among visually impaired children in Bangalore. (21911946)
2011
33
Dental caries-associated risk factors and type 1 diabetes mellitus. (22027069)
2011
34
Reproducibility of adjunct techniques for diagnosis of dental caries in an epidemiological situation. (22068181)
2011
35
Dental caries in adolescents with attention deficit hyperactivity disorder: a population-based follow-up study. (21896055)
2011
36
Cranberry polyphenols: potential benefits for dental caries and periodontal disease. (20943032)
2010
37
An interdisciplinary approach to a survey on dental caries in a group of 3-year-olds in Ascoli Piceno (Italy). (21080754)
2010
38
Oral health suggestion on dental caries, periodontal diseases, dentin hypersensitivity, and malocclusion]. (19575979)
2009
39
Relationship of concentration of lactoferrin and lysozyme in saliva and dental caries in primary dentition]. (19563039)
2009
40
A possible role of LIM mineralization protein 1 in tertiary dentinogenesis of dental caries treatment. (17374459)
2007
41
Selective ablation of surface enamel caries with a pulsed Nd:YAG dental laser. (12116326)
2002
42
Dental disease indices and caries-related microflora in children with glycogen storage disease. (11853251)
2002
43
Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students. (12459324)
2002
44
Dental fluorosis and caries experience in relation to three different drinking water fluoride levels in South Africa. (11572269)
2001
45
Studies of dental root surface caries. 1: Comparison of natural and artificial root caries lesions. (10846269)
2000
46
Root caries and root defects in urban and rural adults: the Florida Dental Care Study. (8754463)
1996
47
Root caries in older people attending a general dental practice in East Sussex. (2223292)
1990
48
Dental caries and dental fluorosis. (3226636)
1988
49
Dental caries, oral hygiene, periodontal disease and dental fluorosis among school children in northern Tanzania. Oral health surveys. (6582453)
1983
50
Induction of dental caries in gnotobiotic rats with a levan-forming streptococcus and a streptococcus isolated from subacute bacterial endocarditis. (5239006)
1968

Genetic Variations for Dental Caries

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Expression for genes affiliated with Dental Caries

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dental Caries

Search GEO for disease gene expression data for Dental Caries.

Pathways for genes affiliated with Dental Caries

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Compounds for genes affiliated with Dental Caries

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Dental Caries according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1cysteine4411.0CST1, CSN1S1, DSPP, OXA1L, LTF, CD79A
2h2o24411.0MMP8, CD79A, LTF, OXA1L, DSPP, CSN1S1
3hydroxyapatite4411.0DSPP, PRAP1, DMP1, HTN1, CSN1S1
4fibrinogen4411.0CSN1S1, OXA1L, LTF, CD79A, MMP8
5pmma4411.0DSPP, OXA1L, LTF, CD79A
6doxycycline44 1112.0DSPP, LTF, CD79A, MMP8
7glutaraldehyde4411.0CD79A, OXA1L, DSPP, CSN1S1
8citrate4411.0CD79A, LTF, DSPP, CSN1S1
9pge24411.0CSN1S1, NR5A2, LTF, CD79A, MMP8
10tannins4411.0OXA1L, DSPP, CSN1S1
11fluoride4410.9CSN1S1, DSPP, CD79A
12exorphins4410.9CSN1S1, LTF
13diazepam44 49 28 1113.9LTF, OXA1L, CSN1S1
14citric acid44 28 11 2413.9LTF, DSPP, CSN1S1
15chlorhexidine2 44 1112.9LTF, DSPP
16vitamin b124410.9CD79A, LTF, CSN1S1
17ascorbic acid44 2411.9CSN1S1, DSPP, LTF, CD79A
18nitrilotriacetic acid44 1111.9LTF, OXA1L
19salicylic acid44 2811.9CSN1S1, DSPP, OXA1L
20polyacrylic acid4410.9CSN1S1, DSPP
21tween 804410.9OXA1L, CSN1S1
22ctab4410.9OXA1L, DSPP
23hypothiocyanite44 2411.9CD79A, LTF
24gluten4410.9CD79A, CSN1S1
25lactulose4410.9LTF, CD79A
26vitamin d4410.8CD79A, DSPP, DMP1, CSN1S1
27deae4410.8CSN1S1, OXA1L
28phenolphthalein44 1111.8OXA1L, LTF
29trichloroacetic acid4410.8DSPP, CSN1S1
30polyethylene glycol4410.8CSN1S1, OXA1L, CD79A
31chloramine t4410.8OXA1L, DSPP
32thiocyanate44 2411.8LTF, CD79A
33pneumococcal4410.8LTF, CD79A
34amoxicillin44 49 1112.8DSPP, LTF
35sodium dodecylsulfate4410.8CD79A, OXA1L, CSN1S1
36tartrate4410.7OXA1L, DSPP
37chloroform4410.7DSPP, OXA1L
38sodium fluoride4410.7CSN1S1, DSPP
39metronidazole44 1111.6LTF, DSPP
40N-Acetyl-D-glucosamine11 2411.6LYZL2, LYZ
41piroxicam44 1111.5OXA1L, CD79A
42whey4410.5LTF, CSN1S1
43cacl24410.4CSN1S1, MMP8
44gliadin4410.2CD79A, CSN1S1

GO Terms for genes affiliated with Dental Caries

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16Gene Ontology
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Cellular components related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.6MMP8, DSPP, OMD, DMP1
2extracellular regionGO:00557610.3LYZL2, CST1, CSN1S1, HTN1, PROL1, PRAP1

Biological processes related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1biomineral tissue developmentGO:03121410.5DSPP, DMP1, HTN1
2cell wall macromolecule catabolic processGO:01699810.5LYZL2, LYZ
3ossificationGO:00150310.4DMP1, DSPP, LTF
4defense response to bacteriumGO:04274210.2LYZ, LTF, HTN1

Molecular functions related to Dental Caries according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysozyme activityGO:00379610.5LYZL2, LYZ

Products for genes affiliated with Dental Caries

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dental Caries

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet