MCID: DNT012
MIFTS: 42

Dental Caries malady

Gastrointestinal diseases category

Aliases & Classifications for Dental Caries

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 33MeSH, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
See all sources

Aliases & Descriptions for Dental Caries:

Name: Dental Caries 8 10 44 61
Dental Caries of Smooth Surface 8 61
Dental Caries Extending into Pulp 8
 
Dental Caries Pit and Fissure 8
Carious Exposure of Pulp 61


Classifications:



External Ids:

Disease Ontology8 DOID:216
MeSH33 D003731
ICD9CM27 521.00, 521.0
NCIt39 C52593
ICD1025 K02

Summaries for Dental Caries

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Wikipedia:64 Dental caries (caries is Latin for \"rottenness\"), also known as tooth decay, cavities, or caries, is... more...

MalaCards based summary: Dental Caries, also known as dental caries of smooth surface, is related to dental fluorosis and periodontitis. An important gene associated with Dental Caries is DSPP (dentin sialophosphoprotein), and among its related pathways are Selected targets of C EBPalpha and Selected targets of ESR1. The drug aluminum chloride and the compounds chlorhexidine and hypothiocyanite have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, bone marrow and bone.

Related Diseases for Dental Caries

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Diseases related to Dental Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1dental fluorosis32.0AMELX
2periodontitis31.5MMP8, LTF
3periodontal disease31.4CD79A, LTF
4root caries31.3DSPP
5gingivitis31.1DSPP, MMP8, LTF
6aggressive periodontitis30.7LTF, MMP8
7asthma30.7CD79A, CSN1S1, OXA1L, MMP8
8arthritis30.3LTF, CSN1S1, MMP8
9rheumatoid arthritis29.8DSPP, MMP8, OXA1L, CSN1S1, CD79A, LTF
10obesity10.7
11urethritis10.5CD79A
12reactive arthritis10.5CD79A
13cryptosporidiosis10.5CD79A
14keratoconjunctivitis sicca10.5LTF
15gastroenteritis10.5CD79A
16hyperthyroxinemia10.5OXA1L
17dentin caries10.4
18down syndrome10.4
19bronchiectasis10.4CD79A, MMP8
20gastroesophageal reflux10.4CSN1S1, DSPP
21lactose intolerance10.3LTF, CSN1S1
22prostatitis10.3LTF, CD79A
23shigellosis10.3LTF, CD79A
24perinatal necrotizing enterocolitis10.3CSN1S1, LTF
25cerebral palsy10.3
26enamel caries10.3
27cerebritis10.3
28chorioamnionitis10.3LTF, MMP8
29otitis media10.3CD79A, LTF
30abdominal aortic aneurysm10.3MMP8, CSN1S1
31mastitis10.3CSN1S1, LTF
32candidiasis10.3LTF, CD79A
33connective tissue disease10.3LTF, DSPP
34celiac disease10.3CD79A, CSN1S1
35amelogenesis imperfecta10.3AMELX, DSPP
36diphtheria10.3CD79A, CSN1S1
37cystic fibrosis10.2
38hemangioma10.2
39cleft lip10.2
40odontoclasia10.2
41endocarditis10.2
42periapical periodontitis10.2
43tooth disease10.2
44iga glomerulonephritis10.2CSN1S1, CD79A
45amyloidosis10.2CSN1S1, CD79A
46diarrhea10.2CSN1S1, CD79A, LTF
47atopy10.2CD79A, CSN1S1
48tetanus10.2OXA1L, CSN1S1, CD79A
49glomerulonephritis10.2OXA1L, CSN1S1, CD79A
50pneumonia10.2CD79A, OXA1L, MMP8

Graphical network of the top 20 diseases related to Dental Caries:



Diseases related to dental caries

Symptoms for Dental Caries

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Drugs & Therapeutics for Dental Caries

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Drug clinical trials:

Search ClinicalTrials for Dental Caries

Search NIH Clinical Center for Dental Caries

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Dental Caries

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Anatomical Context for Dental Caries

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MalaCards organs/tissues related to Dental Caries:

31
Salivary gland, Bone marrow, Bone, Colon, Kidney, Testes

Animal Models for Dental Caries or affiliated genes

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Publications for Dental Caries

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Articles related to Dental Caries:

(show top 50)    (show all 603)
idTitleAuthorsYear
1
Prevalence of dental caries and fissure sealants in a portuguese sample of adolescents. (25803849)
2015
2
The Relationship between Methamphetamine Use and Dental Caries and Missing Teeth. (25883373)
2015
3
Dental caries experience and periodontal treatment needs of children with autistic spectrum disorder. (25385711)
2014
4
Fluoride and dental caries prevention in children. (24385561)
2014
5
The use of sub-ablative Er:YAG laser irradiation in prevention of dental caries during orthodontic treatment. (25368443)
2014
6
The Role of Behaviour in Inequality in Increments of Dental Caries among Finnish Adults. (25401295)
2014
7
Total antioxidant capacity of saliva and dental caries. (23524431)
2013
8
Influence of feeding practices on dental caries. A case-control study. (23597222)
2013
9
Antimicrobial activity of fractions and subfractions of Elaeagia utilis against microorganisms of importance in dental caries. (24303734)
2013
10
Association signals unveiled by a comprehensive gene set enrichment analysis of dental caries genome-wide association studies. (23967329)
2013
11
Dental caries experience and barriers to care in young children with disabilities in Ireland. (23444182)
2013
12
Dental caries and chemical analyses in reconstruction of diet, health and hygienic behaviour in the Middle Euphrates valley (Syria). (23352446)
2013
13
Relationship between dental caries status and anemia in children with severe early childhood caries. (23684139)
2013
14
Dental caries vaccine - a possible option? (23905153)
2013
15
Antibacterial agents in composite restorations for the prevention of dental caries. (24343855)
2013
16
Innovative interventions to promote positive dental health behaviors and prevent dental caries in preschool children: study protocol for a randomized controlled trial. (23782918)
2013
17
Dentists who participate in a practice-based research network may adopt less invasive approaches to treating dental caries. (24237740)
2013
18
Dental caries and oral health practice among 12 year old school children from low socio-economic status background in Zimbabwe. (23819006)
2013
19
Management of dental caries and esthetic issues in the pediatric patient. (24073501)
2013
20
Dental caries prevalence, oral health knowledge and practice among indigenous Chepang school children of Nepal. (23672487)
2013
21
Pulpal involvement-roots-sepsis index: a new method for describing the clinical consequences of untreated dental caries. (23949116)
2013
22
Salivary proteins as a biomarker for dental caries--a systematic review. (23142096)
2013
23
Nonfluoride caries preventive agents show varied effectiveness in preventing dental caries. (22726784)
2012
24
Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis. (23091642)
2012
25
Cost-effectiveness models for dental caries prevention programmes among Chilean schoolchildren. (23488214)
2012
26
MMP13 polymorphism decreases risk for dental caries. (22710194)
2012
27
Fluorosis and dental caries: an assessment of risk factors in Mexican children. (22690531)
2012
28
Exploring the relation between body mass index, diet, and dental caries among 6-12-year-old children. (23514680)
2012
29
Effect of inhaled medication and inhalation technique on dental caries in asthmatic patients. (23483765)
2012
30
Decline in dental caries among 12-year-old children in Brazil, 1980-2005. (23252588)
2012
31
Preventing dental caries in children: Indian scenario. (22971868)
2012
32
Alloxan-induced hyperglycemia causes rapid-onset and progressive dental caries and periodontitis in F344 rats. (22936448)
2012
33
Dental Caries in the Primary Dentition of German Children With Cleft Lip and Palate. (23237430)
2012
34
The natural history of dental caries lesions: a 4-year observational study. (22821238)
2012
35
Inter-relationship of intelligence-quotient and self-concept with dental caries amongst socially handicapped orphan children. (22918097)
2012
36
Antibacterial photodynamic therapy for dental caries: evaluation of the photosensitizers used and light source properties. (22594982)
2012
37
Development of an auxiliary resource for diagnosis of dental caries in epidemiological surveys. (21689374)
2011
38
Dental caries trends in Australian school children. (21770083)
2011
39
Oral health among white, black, and Mexican-American elders: an examination of edentulism and dental caries. (22320289)
2011
40
New directions in the etiology of dental caries disease. (22132583)
2011
41
Association between occlusal anomalies and dental caries in 3- to 5 year-old Brazilian children. (21367823)
2011
42
Dental caries in rats associated with Candida albicans. (21412001)
2011
43
Changes in dental caries in Zurich school-children over a period of 45 years. (21243546)
2010
44
Dental caries as a side effect of infantile hemangioma treatment with propranolol solution. (21510011)
2010
45
Dental caries profile in Monte Negro, Amazonian state of RondA'nia, Brazil, in 2008. (21085797)
2010
46
Dental caries experience among young Australian adults. (21174922)
2010
47
Considerations on optimal fluoride intake using dental fluorosis and dental caries outcomes--a longitudinal study. (19054310)
2009
48
Molluscum contagiosum and dental caries: a pertinent combination. (19915268)
2009
49
Hydrophobic interaction chromatography and capillary zone electrophoresis to explore the correlation between the isoenzymes of salivary alpha-amylase and dental caries. (10219681)
1999
50
Dental caries and dental fluorosis. (3226636)
1988

Variations for Dental Caries

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Expression for genes affiliated with Dental Caries

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Search GEO for disease gene expression data for Dental Caries.

Pathways for genes affiliated with Dental Caries

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Pathways related to Dental Caries according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes

Compounds for genes affiliated with Dental Caries

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Sources:
44Novoseek, 1BitterDB, 11DrugBank, 24HMDB, 50PharmGKB, 28IUPHAR
See all sources

Compounds related to Dental Caries according to GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1chlorhexidine44 1 1112.3DSPP, LTF
2hypothiocyanite44 2411.2CD79A, LTF
3lactulose4410.2CD79A, LTF
4thiocyanate44 2411.1CD79A, LTF
5pneumococcal4410.1LTF, CD79A
6amoxicillin44 50 1112.1LTF, DSPP
7metronidazole44 1111.0DSPP, LTF
8polyacrylic acid4410.0DSPP, CSN1S1
9exorphins449.9CSN1S1, LTF
10gluten449.9CD79A, CSN1S1
11trichloroacetic acid449.9DSPP, CSN1S1
12sodium fluoride449.8CSN1S1, DSPP
13ctab449.7DSPP, OXA1L
14nitrilotriacetic acid44 1110.7OXA1L, LTF
15fluoride449.7DSPP, CD79A, CSN1S1
16chloramine t449.7DSPP, OXA1L
17doxycycline44 1110.7CD79A, DSPP, MMP8, LTF
18citric acid44 28 24 1112.6DSPP, LTF, CSN1S1
19cacl2449.6CSN1S1, MMP8
20phenolphthalein44 1110.6LTF, OXA1L
21vitamin b12449.6CD79A, CSN1S1, LTF
22tartrate449.6OXA1L, DSPP
23chloroform449.5OXA1L, DSPP
24formaldehyde44 2410.5CSN1S1, DSPP, CD79A
25carbohydrates449.5LTF, CSN1S1, DSPP
26gliadin449.5CSN1S1, CD79A
27piroxicam44 1110.4OXA1L, CD79A
28tween 80449.4OXA1L, CSN1S1
29deae449.4CSN1S1, OXA1L
30citrate449.4DSPP, CSN1S1, LTF, CD79A
31ascorbic acid44 2410.3CD79A, DSPP, LTF, CSN1S1
32lactate449.3CD79A, CSN1S1, MMP8, DSPP
33glycerol44 24 1111.3CD79A, CSN1S1, DSPP
34whey449.2LTF, CSN1S1
35phosphatidylcholine449.2CSN1S1, CD79A, LTF
36tannins449.2CSN1S1, OXA1L, DSPP
37pmma449.2OXA1L, DSPP, CD79A, LTF
38salicylic acid44 2810.2OXA1L, CSN1S1, DSPP
39polyethylene glycol449.1OXA1L, CD79A, CSN1S1
40diazepam44 28 50 1112.1OXA1L, CSN1S1, LTF
41sodium dodecylsulfate449.1CD79A, OXA1L, CSN1S1
42alanine449.0MMP8, LTF, CD79A, CSN1S1, DSPP
43thyroxine44 2410.0CD79A, CSN1S1, OXA1L
44glutaraldehyde448.9OXA1L, DSPP, CD79A, CSN1S1
45pge2448.8CD79A, NR5A2, CSN1S1, LTF, MMP8
46estrogen448.8CSN1S1, CD79A, LTF, DSPP, NR5A2
47retinoic acid44 249.7CSN1S1, LTF, CD79A, MMP8, NR5A2
48fibrinogen448.5LTF, MMP8, CD79A, CSN1S1, OXA1L
49h2o2448.2CD79A, DSPP, MMP8, LTF, CSN1S1, OXA1L
50cysteine448.2DSPP, MMP8, OXA1L, LTF, CD79A, CSN1S1

GO Terms for genes affiliated with Dental Caries

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Cellular components related to Dental Caries according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.5MMP8, DSPP, AMELX

Biological processes related to Dental Caries according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ossificationGO:00015039.8LTF, DSPP
2biomineral tissue developmentGO:00312149.7DSPP, AMELX
3odontogenesis of dentin-containing toothGO:00424759.4NKX2-3, AMELX

Sources for Dental Caries

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet