MCID: DNT013
MIFTS: 24

Dental Enamel Hypoplasia malady

Oral diseases category

Aliases & Classifications for Dental Enamel Hypoplasia

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Sources:
10Disease Ontology, 12DISEASES, 36MeSH, 47Novoseek, 42NCIt, 65UMLS, 59SNOMED-CT
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Aliases & Descriptions for Dental Enamel Hypoplasia:

Name: Dental Enamel Hypoplasia 10 12 36
 
Enamel Hypoplasia 10 47


Classifications:



External Ids:

Disease Ontology10 DOID:693
NCIt42 C34529
SNOMED-CT59 196277000, 26597004
MeSH36 D003744

Summaries for Dental Enamel Hypoplasia

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MalaCards based summary: Dental Enamel Hypoplasia, also known as enamel hypoplasia, is related to amelogenesis imperfecta hypoplastic type, ig and deafness enamel hypoplasia nail defects. An important gene associated with Dental Enamel Hypoplasia is ENAM (Enamelin), and among its related pathways are Collagen biosynthesis and modifying enzymes and ECM proteoglycans. Affiliated tissues include testes, and related mouse phenotype craniofacial.

Related Diseases for Dental Enamel Hypoplasia

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Diseases related to Dental Enamel Hypoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1amelogenesis imperfecta hypoplastic type, ig29.3AMELX, C4orf26, KLK4, MMP20, SLC24A4, WDR72
2deafness enamel hypoplasia nail defects10.6
3alaninuria with microcephaly, dwarfism, enamel hypoplasia and diabetes mellitus10.5
4shaheen syndrome10.4
5heimler syndrome 110.3
6amelogenesis imperfecta, type 1e10.3
7enamel hypoplasia cataract hydrocephaly10.3
8hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome10.3
9seckel syndrome 110.2
10celiac disease10.2
11amelogenesis imperfecta10.2
12rapp-hodgkin syndrome10.2
13amelogenesis imperfecta, type ib10.2
14intestinal lymphangiectasia10.2
15cutaneous mastocytosis10.1ENAM, MMP20
16childhood brain meningioma10.1DSPP, ENAM
17hernia of ovary and fallopian tube10.1DSPP, ENAM
18ladd syndrome10.1
19heimler syndrome 210.1
20peroxisome biogenesis disorder 1a10.1
21galactosemia10.1
22hamamy syndrome10.1
23trichodontoosseous syndrome10.1
24arterial calcification of infancy10.1
25seckel syndrome10.1
26usher syndrome10.1
27dental fluorosis10.1
28nephrocalcinosis10.1
29rickets10.1
30protein-losing enteropathy10.1
31epidermolysis bullosa simplex10.1
32epidermolysis bullosa10.1
33amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 210.1
34pfeiffer palm teller syndrome10.1
35phace syndrome10.1
36seow najjar syndrome10.1
37tricho-dento-osseous syndrome10.1
38tricho-dento-osseous syndrome 110.1
39ataxia10.1
40malignant pleural solitary fibrous tumor10.0ENAM, WDR72
41anodontia10.0DSPP, MMP20
42dentinogenesis imperfecta10.0DSPP, ENAM
43autoimmune disease of skin and connective tissue10.0AMELX, ENAM
44dental enamel hypoplasia10.0AMELX, DSPP, ENAM
45esophageal duplication cyst9.7ENAM, ITGB6, LAMB3
46solitary necrotic tumor of the liver9.3DSPP, ENAM, FAM83H, ITGB6, MMP20, SLC24A4
47anal fistula8.5AMELX, C4orf26, DSPP, ENAM, FAM83H, ITGB6
48dental pulp disease8.5AMELX, C4orf26, DSPP, ENAM, FAM83H, ITGB6
49gastrointestinal tuberculosis8.5AMELX, C4orf26, DSPP, ENAM, FAM83H, ITGB6
50movement disease8.5AMELX, C4orf26, DSPP, ENAM, FAM83H, ITGB6

Graphical network of the top 20 diseases related to Dental Enamel Hypoplasia:



Diseases related to dental enamel hypoplasia

Symptoms for Dental Enamel Hypoplasia

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Drugs & Therapeutics for Dental Enamel Hypoplasia

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Drugs for Dental Enamel Hypoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Carticaine21

Interventional clinical trials:

idNameStatusNCT IDPhase
1Comparison of Intraosseous Anaesthesia Using a Computerized System (QuickSleeper) to Conventional AnesthesiaRecruitingNCT02084433
2Amelogenesis ImperfectaRecruitingNCT01746121

Search NIH Clinical Center for Dental Enamel Hypoplasia


Cochrane evidence based reviews: Dental Enamel Hypoplasia

Genetic Tests for Dental Enamel Hypoplasia

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Anatomical Context for Dental Enamel Hypoplasia

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MalaCards organs/tissues related to Dental Enamel Hypoplasia:

33
Testes

Animal Models for Dental Enamel Hypoplasia or affiliated genes

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MGI Mouse Phenotypes related to Dental Enamel Hypoplasia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053827.5AMELX, DSPP, ENAM, KLK4, LAMB3, MMP20

Publications for Dental Enamel Hypoplasia

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Articles related to Dental Enamel Hypoplasia:

idTitleAuthorsYear
1
The possible correlation between dental enamel hypoplasia and a historic natural disaster in the Roman population of Herculaneum (79 AD - central Italy). (24620565)
2013
2
Patterns in dental enamel hypoplasia by sex and age at death in two archaeological populations. (18990363)
2009
3
NF1 microduplication first clinical report: association with mild mental retardation, early onset of baldness and dental enamel hypoplasia? (18183042)
2008
4
Early childhood stress and adult age mortality--a study of dental enamel hypoplasia in the medieval Danish village of Tirup. (16897774)
2007
5
Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region. (17537244)
2007
6
Dental enamel hypoplasia apropos of a case]. (8620979)
1996
7
Hypoplastic area method for analyzing dental enamel hypoplasia. (8599384)
1995
8
Frequency and chronological distribution of dental enamel hypoplasia in enslaved African Americans: a test of the weaning hypothesis. (7864059)
1994
9
Incidence and patterning of dental enamel hypoplasia among the Neandertals. (2665513)
1989
10
Prevalence and possible etiology of dental enamel hypoplasia. (637120)
1978

Variations for Dental Enamel Hypoplasia

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Expression for genes affiliated with Dental Enamel Hypoplasia

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Search GEO for disease gene expression data for Dental Enamel Hypoplasia.

Pathways for genes affiliated with Dental Enamel Hypoplasia

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GO Terms for genes affiliated with Dental Enamel Hypoplasia

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Cellular components related to Dental Enamel Hypoplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055788.9AMELX, DSPP, ENAM, MMP20
2extracellular regionGO:00055768.2C4orf26, DSPP, KLK4, LAMB3, MMP20

Biological processes related to Dental Enamel Hypoplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein catabolic processGO:003016310.2KLK4, MMP20
2odontogenesis of dentin-containing toothGO:004247510.1AMELX, ENAM
3amelogenesisGO:00971869.5ENAM, KLK4, MMP20, SLC24A4
4biomineral tissue developmentGO:00312149.5AMELX, DSPP, ENAM, FAM83H
5extracellular matrix disassemblyGO:00226179.0KLK4, LAMB3, MMP20
6extracellular matrix organizationGO:00301988.2DSPP, ITGB6, LAMB3, MMP20

Sources for Dental Enamel Hypoplasia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet