MCID: DNT001
MIFTS: 44

Dental Fluorosis malady

Gastrointestinal diseases, Oral diseases categories

Summaries for Dental Fluorosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Dental fluorosis, also called mottling of tooth enamel, is a developmental disturbance of dental enamel... more...

MalaCards: Dental Fluorosis, also known as intrinsic enamel discolouration of fluorosis, is related to dental caries and dentin dysplasia. An important gene associated with Dental Fluorosis is AMELY (amelogenin, Y-linked), and among its related pathways are Cell adhesion ECM remodeling and Degradation of the extracellular matrix. The compounds xbai and calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and testes, and related mouse phenotype craniofacial.

Aliases & Classifications for Dental Fluorosis

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

dental fluorosis 8 10
intrinsic enamel discolouration of fluorosis 8
dental fluorosis, acquired 60
mottling of enamel 8
mottled teeth 8


External Ids:

Disease Ontology8 DOID:13711
ICD9CM27 520.3
NCIt39 C85059
SNOMED-CT56 30265004
MeSH34 D009050
ICD1025 K00.3

Related Diseases for Dental Fluorosis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to dental fluorosis

Clinical Features for Dental Fluorosis

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Drugs & Therapeutics for Dental Fluorosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Dental Fluorosis

Search CenterWatch for Dental Fluorosis

Genetic Tests for Dental Fluorosis

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Anatomical Context for Dental Fluorosis

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32MalaCards
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MalaCards organs/tissues related to Dental Fluorosis:

32
Bone, Thyroid, Testes

Animal Models for Dental Fluorosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dental Fluorosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.8MMP20, DSPP, AKR1A1, TFPI, AMELX, KLK4

Publications for Dental Fluorosis

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50PubMed
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Articles related to Dental Fluorosis:

(show top 50)    (show all 385)
idTitleAuthorsYear
1
A pioneering study of dental fluorosis in the libyan population. (24155605)
2013
2
Typical radiographic findings of dentin dysplasia type 1b with dental fluorosis. (24367729)
2013
3
Fluorosis and dental caries: an assessment of risk factors in Mexican children. (22690531)
2012
4
Dental caries and dental fluorosis in children on the NSW Central Coast: a cross-sectional study of fluoridated and non-fluoridated areas. (22672044)
2012
5
The association between social deprivation and the prevalence and severity of dental caries and fluorosis in populations with and without water fluoridation. (23272895)
2012
6
Fine mapping of dental fluorosis quantitative trait loci in mice. (22243220)
2011
7
Severe dental fluorosis and jowar consumption in Karnataka, India. (20636413)
2010
8
Preliminary evidence of an association between COL1A2 polymorphisms and dental fluorosis in a population with high fluoride exposure. (20466318)
2010
9
Osteo-dental fluorosis in relation to age and sex in tribal districts of Rajasthan, India. (21391391)
2010
10
Fluoride in drinking water and dental fluorosis. (20580811)
2010
11
Dental fluorosis and its association with the use of fluoridated toothpaste among middle school students of Delhi. (22301803)
2010
12
Agreement in the diagnosis of dental fluorosis in central incisors performed by a standardized photographic method and clinical examination. (19488486)
2009
13
Detection of dental fluorosis-associated quantitative trait Loci on mouse chromosomes 2 and 11. (18701810)
2009
14
The relationships between two different drinking water fluoride levels, dental fluorosis and bone mineral density of children. (19444344)
2009
15
Evaluation of craniofacial morphology of children with dental fluorosis in early permanent dentition period. (19826603)
2009
16
COL1A2 gene polymorphisms (Pvu II and Rsa I), serum calciotropic hormone levels, and dental fluorosis. (18284430)
2008
17
Agreement amongst examiners assessing dental fluorosis from digital photographs using the TF index. (17405466)
2007
18
Dental fluorosis and dental caries among 12-yr-old children from high- and low-fluoride areas in Lithuania. (17451504)
2007
19
Dental fluorosis in Brazil: a systematic review from 1993 to 2004. (16917577)
2006
20
Prevalence of dental fluorosis in children from non-water-fluoridated Halmstad, Sweden: fluoride toothpaste use in infancy. (16095064)
2005
21
Dental caries, its surface susceptibility and dental fluorosis in South India. (16379138)
2005
22
Dental fluorosis increases caries risk. (17138367)
2005
23
Dental caries and dental fluorosis in 7-12-year-old schoolchildren in CatalALo, GoiA!s, Brazil. (20944878)
2005
24
Development of a questionnaire to measure perceptions of, and concerns derived from, dental fluorosis. (15617415)
2004
25
Dental fluorosis: variability among different inbred mouse strains. (12407097)
2002
26
Dental fluorosis decline after changes to supplement and toothpaste regimens. (12000347)
2002
27
A study of some parameters in stimulated saliva from adolescents with dental fluorosis. (11848187)
2001
28
Intra-oral distribution of dental fluorosis in Newburgh and Kingston, New York. (11005736)
2000
29
Re: Vegetarianism and dental fluorosis among children in a high fluoride area of northern Tanzania (1999;9: 3-11) (10841607)
1999
30
Altitude as a risk indicator of dental fluorosis in children residing in areas with 0.5 and 2.5 mg fluoride per litre in drinking water. (10343089)
1999
31
Severe dental fluorosis in a Tanzanian population consuming water with negligible fluoride concentration. (9870537)
1998
32
Dental fluorosis in Chilean children: evaluation of risk factors. (9792122)
1998
33
Dental caries and dental fluorosis among schoolchildren who were lifelong residents of communities having either low or optimal levels of fluoride in drinking water. (9608443)
1998
34
Dental fluorosis and the use of a high fluoride-containing trona tenderizer (magadi). (9181293)
1997
35
Trends in prevalence of dental fluorosis in North America. (8070241)
1994
36
The severity of dental fluorosis in children exposed to water with a high fluoride content for various periods of time. (2045574)
1991
37
The nature and mechanisms of dental fluorosis in man. (2179331)
1990
38
The prevalence of dental fluorosis. (2810211)
1989
39
Fluoride content of infant formulas: soy-based formulas as a potential factor in dental fluorosis. (3268804)
1988
40
Dental fluorosis in the primary and the permanent dentition in fluoridated areas with consumption of either powdered milk or natural cow's milk. (3163350)
1988
41
Fluoride supplement-induced dental fluorosis: case reports. (3268798)
1988
42
Enamel fluoride, dental fluorosis and dental caries among immigrants to and permanent residents of five Danish fluoride areas. (3459585)
1986
43
A new method for assessing the prevalence of dental fluorosis--the Tooth Surface Index of Fluorosis. (6611361)
1984
44
Endemic dental fluorosis and the possibilities of defluoridation and fluoridation of water supplies in Tanzania. (6593698)
1984
45
Dental caries, oral hygiene, periodontal disease and dental fluorosis among school children in northern Tanzania. Oral health surveys. (6582453)
1983
46
Clinical and structural features and possible pathogenic mechanisms of dental fluorosis. (272716)
1977
47
Caries experience and fluoride concentration of surface enamel in dental fluorosis patients. (234797)
1975
48
Assessment of the fluoride content of water in wells selected randomly and after examining schoolchildren for dental fluorosis. (4546731)
1973
49
Dental caries and dental fluorosis in Thailand. (4378950)
1965
50
Endemic dental fluorosis in Kenya; a preliminary report. (13083574)
1953

Genetic Variations for Dental Fluorosis

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Expression for genes affiliated with Dental Fluorosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dental Fluorosis

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Pathways for genes affiliated with Dental Fluorosis

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12EMD Millipore, 53Reactome, 49PharmGKB, 51QIAGEN, 37NCBI BioSystems Database
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Compounds for genes affiliated with Dental Fluorosis

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Dental Fluorosis according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1xbai4410.1ESR2, COL1A2
2calcium carbonate4410.0DSPP, BGLAP
3thymol44 2810.9DSPP, AKR1A1
4carbodiimide449.9AKR1A1, COL1A2
5tartrate449.9BGLAP, DSPP
6fluoride449.8BGLAP, DSPP, MMP20
7sodium fluoride449.8DSPP, BGLAP
8rsai449.7ESR2, AKR1A1, COL1A2
9pyrazole44 1110.7AKR1A1, ESR2
10exemestane49 44 59 1112.6BGLAP, ESR2
11vitamin d449.5ESR2, DSPP, BGLAP, COL1A2
12polyglycolic acid449.4DSPP, AKR1A1, BGLAP
13guanidine hydrochloride449.4BGLAP, AKR1A1, DSPP
14sodium bicarbonate44 1110.4DSPP, AKR1A1
15h2o2448.8BGLAP, TFPI, AKR1A1, DSPP, ESR2
16serine448.1KLK4, COL1A2, BGLAP, TFPI, AKR1A1, DSPP

GO Terms for genes affiliated with Dental Fluorosis

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16Gene Ontology
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Cellular components related to Dental Fluorosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055788.8MMP25, MMP20, DSPP, AMTN, AMELX, AMELY
2extracellular regionGO:0055768.4COL1A2, BGLAP, TFPI, ANGPTL6, MMP20, CFI

Biological processes related to Dental Fluorosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1amelogenesisGO:0971869.8MMP20, KLK4
2skeletal system developmentGO:0015019.6DSPP, BGLAP, COL1A2
3biomineral tissue developmentGO:0312149.5DSPP, AMTN, AMELX, AMELY

Molecular functions related to Dental Fluorosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of tooth enamelGO:03034510.1AMELX, AMELY
2hydroxyapatite bindingGO:0468489.5AMELX, BGLAP

Products for genes affiliated with Dental Fluorosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dental Fluorosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet