MCID: DNT001
MIFTS: 41

Dental Fluorosis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Fluorosis

Aliases & Descriptions for Dental Fluorosis:

Name: Dental Fluorosis 12 14
Intrinsic Enamel Discolouration of Fluorosis 12
Dental Fluorosis, Acquired 69
Mottling of Enamel 12
Fluorosis, Dental 42
Mottled Teeth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13711
ICD10 33 K00.3
ICD9CM 35 520.3
MeSH 42 D009050
NCIt 47 C85059
UMLS 69 C0026618

Summaries for Dental Fluorosis

MalaCards based summary : Dental Fluorosis, also known as intrinsic enamel discolouration of fluorosis, is related to dental caries and deafness, autosomal recessive 21, and has symptoms including toothache An important gene associated with Dental Fluorosis is COL1A2 (Collagen Type I Alpha 2 Chain), and among its related pathways/superpathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Validated transcriptional targets of AP1 family members Fra1 and Fra2. The drugs Fluorides and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and testes.

Wikipedia : 71 Dental fluorosis (also termed mottled enamel) is an extremely common disorder, characterized by... more...

Related Diseases for Dental Fluorosis

Diseases related to Dental Fluorosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
id Related Disease Score Top Affiliating Genes
1 dental caries 10.6
2 deafness, autosomal recessive 21 10.2 ESR1 ESR2
3 her2-receptor negative breast cancer 10.2 ESR1 ESR2
4 muscle hypertrophy 10.2 COL1A2 DSPP
5 adams-oliver syndrome 6 10.2 BGLAP ESR1
6 ulceroglandular tularemia 10.2 ESR1 ESR2
7 osteogenesis imperfecta 10.2 ESR1 ESR2
8 acute thyroiditis 10.2 ESR1 ESR2
9 substance abuse 10.2 ESR1 ESR2
10 perinatal jaundice due to hepatocellular damage 10.2 ESR1 ESR2
11 deafness, autosomal recessive 74 10.2 ESR1 ESR2
12 diabetic neuropathy 10.2 COL1A2 DSPP
13 larynx leiomyoma 10.2 DSPP ESR1
14 carbuncle 10.1 ESR1 ESR2
15 prostatocystitis 10.1 BGLAP COL1A2 DSPP
16 mental retardation, autosomal recessive 35 10.1 BGLAP COL1A2
17 amniotic band syndrome 10.1 AMELX MMP20
18 scapuloperoneal myopathy 10.1 COL1A2 ESR1 ESR2
19 dysbaric osteonecrosis 10.1 BGLAP ESR1 ESR2
20 osteogenesis imperfecta, type ii 10.1 COL1A2 DSPP
21 taeniasis 10.1 COL1A2 DSPP MMP20
22 retinitis pigmentosa 59 10.1 AMELX AMELY
23 peeling skin syndrome 10.1 ESR1 ESR2
24 ocular cancer 10.1 AMELX AMELY
25 fetal hemoglobin quantitative trait locus 3 10.1 AMELX AMELY
26 intramuscular hemangioma 10.0 AMELX AMELY
27 childhood endodermal sinus tumor 10.0 AMELY DSPP
28 reticular perineurioma 10.0 AMBN DSPP MMP20
29 carnitine deficiency, systemic primary 10.0 BGLAP COL1A2 ESR1 ESR2
30 breast cystic hypersecretory carcinoma 9.9 AMELX AMELY
31 basal cell carcinoma 9.9 AMELX AMELY DSPP
32 bronchus cancer 9.9 AMELX AMELY DSPP
33 brown-vialetto-van laere syndrome 2 9.9 AMBN AMELX MMP20
34 angioimmunoblastic lymphadenopathy with dysproteinemia 9.9 AMBN AMELX MMP20
35 fungal gastritis 9.9 AMELX AMELY DSPP
36 thyroiditis 9.9
37 periodontitis 9.9
38 diabetes insipidus 9.9
39 arrhythmogenic right ventricular dysplasia 4 9.9 AMBN AMELX AMELY
40 female breast upper-inner quadrant cancer 9.8 AMELX AMELY
41 burns 9.8
42 dentin dysplasia 9.8
43 gingivitis 9.8
44 periodontal disease 9.8
45 taurodontism 9.8
46 amelogenesis imperfecta 9.8
47 accommodative spasm 9.7 AMBN AMELX AMELY DSPP
48 ovarian malignant mesothelioma 9.6 AMBN AMELX AMELY DSPP MMP20
49 neuroschistosomiasis 8.7 AMBN AMELX AMELY BGLAP COL1A2 DSPP

Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to Dental Fluorosis

Symptoms & Phenotypes for Dental Fluorosis

UMLS symptoms related to Dental Fluorosis:


toothache

Drugs & Therapeutics for Dental Fluorosis

Drugs for Dental Fluorosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fluorides Phase 3,Phase 1
2 Protective Agents Phase 3,Phase 1
3 Cariostatic Agents Phase 3,Phase 1
4 sodium fluoride Approved Phase 1 7681-49-4
5
Calcium carbonate Approved Phase 1 471-34-1
6 Gastrointestinal Agents Phase 1
7 Antacids Phase 1
8 Pharmaceutical Solutions Phase 1
9 Listerine Phase 1
10 Anti-Ulcer Agents Phase 1
11 Calcium, Dietary Phase 1
12
Ethanol Approved 64-17-5 702
13
Hydrogen peroxide 7722-84-1 784
14 Immunoconjugates
15 Anti-Infective Agents
16 Anti-Infective Agents, Local
17 Anesthetics

Interventional clinical trials:


id Name Status NCT ID Phase
1 Effect of pH and Fluoride Concentration of Dentifrices on Caries Control Completed NCT01049503 Phase 3
2 Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes Completed NCT01589991 Phase 1
3 Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as Abrasives Completed NCT01571050 Phase 1
4 Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated Water Completed NCT01978041 Phase 1
5 Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains Completed NCT01733888
6 Fluoride Intake From Toothbrushig With Children's or Regular Toothpastes Completed NCT01568541
7 Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits Active, not recruiting NCT02958891
8 Action of Infiltration Resin Icon in Fluorosis, Clinical Trial, Monitoring for 12 Month Not yet recruiting NCT02925780

Search NIH Clinical Center for Dental Fluorosis

Cochrane evidence based reviews: fluorosis, dental

Genetic Tests for Dental Fluorosis

Anatomical Context for Dental Fluorosis

MalaCards organs/tissues related to Dental Fluorosis:

39
Bone, Thyroid, Testes, Brain

Publications for Dental Fluorosis

Articles related to Dental Fluorosis:

(show top 50) (show all 440)
id Title Authors Year
1
Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways. ( 27871895 )
2017
2
Impact of Dental Fluorosis, Socioeconomic Status and Self-Perception in Adolescents Exposed to a High Level of Fluoride in Water. ( 28085102 )
2017
3
Risk factors and prevalence of dental fluorosis and dental caries in school children of North India. ( 28025807 )
2017
4
Dietary Fluoride Intake and Associated Skeletal and Dental Fluorosis in School Age Children in Rural Ethiopian Rift Valley. ( 27472351 )
2016
5
Dental Fluorosis and Catalase Immunoreactivity of the Brain Tissues in Rats Exposed to High Fluoride Pre- and Postnatally. ( 27052310 )
2016
6
Independent and Additive Effects of Different Sources of Fluoride and Dental Fluorosis. ( 27306248 )
2016
7
The prevalence of dental fluorosis and exposure to fluoride in drinking water: A systematic review. ( 27651877 )
2016
8
Validation of ICMR index for identification of dental fluorosis in epidemiological studies. ( 27834326 )
2016
9
Grading and quantification of dental fluorosis in zebrafish larva. ( 27300491 )
2016
10
Prevalence of Dental Fluorosis and associated Risk Factors in Bagalkot District, Karnataka, India. ( 27843259 )
2016
11
LS8 cell apoptosis induced by NaF through p-ERK and p-JNK - a mechanism study of dental fluorosis. ( 27624793 )
2016
12
Application of quantitative light-induced fluorescence to determine the depth of demineralization of dental fluorosis in enamel microabrasion: a case report. ( 27508165 )
2016
13
Is there an association between the presence of dental fluorosis and dental trauma amongst school children? ( 26960108 )
2016
14
Dental fluorosis, fluoride in urine, and nutritional status in adolescent students living in the rural areas of Guanajuato, Mexico. ( 28032042 )
2016
15
Prevalence of dental fluorosis among primary school children in association with different water fluoride levels in Mysore district, Karnataka. ( 27237204 )
2016
16
Chronic Exposure to Bisphenol A Exacerbates Dental Fluorosis in Growing Rats. ( 27257137 )
2016
17
Dental fluorosis and urinary fluoride concentration as a reflection of fluoride exposure and its impact on IQ level and BMI of children of Laxmisagar, Simlapal Block of Bankura District, W.B., India. ( 26960765 )
2016
18
Natural history and long-term impact of dental fluorosis: a prospective cohort study. ( 26763813 )
2016
19
Caries with Dental Fluorosis and Oral Health Behaviour Among 12-Year School Children in Moderate-Fluoride Drinking Water Community in Quetta, Pakistan. ( 27671177 )
2016
20
The prevalence of dental fluorosis and its associated factors in Salem district. ( 27307668 )
2016
21
Enzymatic Activity of Glutathione S-Transferase and Dental Fluorosis Among Children Receiving Two Different Levels of Naturally Fluoridated Water. ( 27449362 )
2016
22
Nutritional status and dental fluorosis among schoolchildren in communities with different drinking water fluoride concentrations in a central region in Mexico. ( 26426374 )
2015
23
Dental fluorosis and its influence on children's life. ( 25590503 )
2015
24
Differential diagnosis of dental fluorosis made by undergraduate dental students. ( 26761552 )
2015
25
Association of Temporomandibular Joint Signs & Symptoms with Dental Fluorosis & Skeletal Manifestations in Endemic Fluoride Areas of Dungarpur District, Rajasthan, India. ( 26816986 )
2015
26
Evaluation of Fluoride Retention Due to Most Commonly Consumed Estuarine Fishes Among Fish Consuming Population of Andhra Pradesh as a Contributing Factor to Dental Fluorosis: A Cross-Sectional Study. ( 26266208 )
2015
27
Fluoride Exposure Effects and Dental Fluorosis in Children in Mexico City. ( 26609898 )
2015
28
Collagenase 1A2 (COL1A2) gene A/C polymorphism in relation to severity of dental fluorosis. ( 26564713 )
2015
29
DENTAL FLUOROSIS AND ITS RELATION TO SOCIOECONOMIC STATUS, PARENTS' KNOWLEDGE AND AWARENESS AMONG 12-YEAR-OLD SCHOOL CHILDREN IN QUETTA, PAKISTAN. ( 26513940 )
2015
30
Dental fluorosis in the Blue Mountains and Hawkesbury, New South Wales, Australia: policy implications. ( 25511082 )
2015
31
Dental fluorosis and skeletal fluoride content as biomarkers of excess fluoride exposure in marsupials. ( 26188404 )
2015
32
Severe dental fluorosis and cognitive deficits. ( 25576911 )
2015
33
Timing of fluoride intake and dental fluorosis on late-erupting permanent teeth. ( 26198477 )
2015
34
Dental fluorosis: A histological study using Light and Confocal microscopy. ( 26275189 )
2015
35
Correction: Methodological discussion about prevalence of the dental fluorosis on dental health surveys. ( 26153681 )
2015
36
Association between urine fluoride and dental fluorosis as a toxicity factor in a rural community in the state of San Luis Potosi. ( 25789336 )
2015
37
"Borderline" fluorotic region in Serbia: correlations among fluoride in drinking water, biomarkers of exposure and dental fluorosis in schoolchildren. ( 26423526 )
2015
38
Adult perceptions of dental fluorosis and select dental conditions-an Asian perspective. ( 26564646 )
2015
39
Dental fluorosis: prevalence and associated factors in 12-year-old schoolchildren in GoiAcnia, GoiA!s. ( 26247182 )
2015
40
Relationship Between Dental Fluorosis and Intelligence Quotient of School Going Children In and Around Lucknow District: A Cross-Sectional Study. ( 26673535 )
2015
41
Comment on "Severe dental fluorosis and cognitive deficits". ( 25986437 )
2015
42
Fluoride exposure from groundwater as reflected by urinary fluoride and children's dental fluorosis in the Main Ethiopian Rift Valley. ( 25084227 )
2014
43
Bovine calves as ideal bio-indicators for fluoridated drinking water and endemic osteo-dental fluorosis. ( 24671615 )
2014
44
Factors associated with dental fluorosis in school children in southern Brazil: a cross-sectional study. ( 24878674 )
2014
45
Prevalence of dentine hypersensitivity in Chinese rural adults with dental fluorosis. ( 24484047 )
2014
46
The role of partial recording protocols in reporting prevalence and severity of dental fluorosis. ( 24995860 )
2014
47
The effect of non-fluoride factors on risk of dental fluorosis: evidence from rural populations of the Main Ethiopian Rift. ( 24462132 )
2014
48
Enamel crystals of mice susceptible or resistant to dental fluorosis: an AFM study. ( 25025555 )
2014
49
A comparative study of fluoride ingestion levels, serum thyroid hormone & TSH level derangements, dental fluorosis status among school children from endemic and non-endemic fluorosis areas. ( 24455464 )
2014
50
Retention of fissure sealants in young permanent molars affected by dental fluorosis: a 12-month clinical study. ( 24737141 )
2014

Variations for Dental Fluorosis

Expression for Dental Fluorosis

Search GEO for disease gene expression data for Dental Fluorosis.

Pathways for Dental Fluorosis

GO Terms for Dental Fluorosis

Cellular components related to Dental Fluorosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 AMBN AMELX BGLAP COL1A2 DSPP ESR2
2 extracellular matrix GO:0031012 9.43 AMELY COL1A2 MMP20
3 endoplasmic reticulum lumen GO:0005788 9.26 AMBN AMELX BGLAP COL1A2
4 proteinaceous extracellular matrix GO:0005578 9.1 AMBN AMELX AMELY COL1A2 DSPP MMP20

Biological processes related to Dental Fluorosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 odontogenesis of dentin-containing tooth GO:0042475 9.37 AMBN AMELX
2 skeletal system development GO:0001501 9.33 BGLAP COL1A2 DSPP
3 odontogenesis GO:0042476 9.32 BGLAP COL1A2
4 intracellular estrogen receptor signaling pathway GO:0030520 9.26 ESR1 ESR2
5 biomineral tissue development GO:0031214 9.02 AMBN AMELX AMELY BGLAP DSPP
6 tooth mineralization GO:0034505 8.96 AMELX AMELY

Molecular functions related to Dental Fluorosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.46 ESR1 ESR2
2 core promoter sequence-specific DNA binding GO:0001046 9.43 ESR1 ESR2
3 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.4 ESR1 ESR2
4 steroid binding GO:0005496 9.37 ESR1 ESR2
5 estrogen receptor activity GO:0030284 9.32 ESR1 ESR2
6 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
7 hydroxyapatite binding GO:0046848 9.16 AMELX BGLAP
8 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
9 structural constituent of tooth enamel GO:0030345 8.8 AMBN AMELX AMELY

Sources for Dental Fluorosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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