MCID: DNT001
MIFTS: 44

Dental Fluorosis malady

Gastrointestinal diseases, Oral diseases categories

Summaries for Dental Fluorosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Dental fluorosis, also called mottling of tooth enamel, is a developmental disturbance of dental enamel... more...

MalaCards: Dental Fluorosis, also known as intrinsic enamel discolouration of fluorosis, is related to dental caries and dentin dysplasia. An important gene associated with Dental Fluorosis is AMELY (amelogenin, Y-linked), and among its related pathways are Degradation of the extracellular matrix and Cell adhesion ECM remodeling. The compounds xbai and calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and testes, and related mouse phenotype craniofacial.

Aliases & Classifications for Dental Fluorosis

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

dental fluorosis 8 10
intrinsic enamel discolouration of fluorosis 8
dental fluorosis, acquired 60
mottling of enamel 8
mottled teeth 8


External Ids:

Disease Ontology8 DOID:13711
ICD9CM27 520.3
NCIt39 C85059
SNOMED-CT56 30265004
MeSH34 D009050
ICD1025 K00.3

Related Diseases for Dental Fluorosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to dental fluorosis

Clinical Features for Dental Fluorosis

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Drugs & Therapeutics for Dental Fluorosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Dental Fluorosis

Search CenterWatch for Dental Fluorosis

Genetic Tests for Dental Fluorosis

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Anatomical Context for Dental Fluorosis

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32MalaCards
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MalaCards organs/tissues related to Dental Fluorosis:

32
Bone, Thyroid, Testes

Animal Models for Dental Fluorosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dental Fluorosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.8MMP20, DSPP, AKR1A1, TFPI, AMELX, KLK4

Publications for Dental Fluorosis

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50PubMed
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Articles related to Dental Fluorosis:

(show top 50)    (show all 385)
idTitleAuthorsYear
1
Osteo-dental fluorosis in relation to chemical constituents of drinking waters. (23741872)
2012
2
Dental fluorosis in populations from Chiang Mai, Thailand with different fluoride exposures - paper 1: assessing fluorosis risk, predictors of fluorosis and the potential role of food preparation. (22720834)
2012
3
Study of thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) in subjects with dental fluorosis. (22509122)
2012
4
Prevalence of dental caries among 13 and 15-year-old school children in an endemic fluorosis area: a cross-sectional study. (22269235)
2011
5
Assessment of periodontal status among dental fluorosis subjects using community periodontal index of treatment needs. (21891894)
2011
6
A literature review of aesthetic perceptions of dental fluorosis and relationships with psychosocial aspects/oral health-related quality of life. (20002631)
2010
7
Dental fluorosis. (19274507)
2009
8
Study on the relationship between ER Rsa I gene polymorphism and children's dental fluorosis]. (19950602)
2009
9
Prevalence of dental fluorosis among primary school children in rural areas of chidambaram taluk, cuddalore district, Tamil Nadu, India. (19876473)
2008
10
Dental fluorosis in cohorts born before, during, and after the national salt fluoridation program in a community in Mexico. (16829495)
2006
11
Relationship between dental caries experience (DMFS) and dental fluorosis in 12-year-old Puerto Ricans. (17194073)
2006
12
Dental fluorosis in salt fluoridation schemes. (16342643)
2005
13
Prevalence of dental fluorosis in rural areas of Davangere, India. (15503846)
2004
14
A review of the prevalence of dental fluorosis in Mexico. (14987453)
2004
15
Is fluoride concentration in dentin and enamel a good indicator of dental fluorosis? (14691118)
2004
16
The relationship between dental caries and dental fluorosis in areas with moderate- and high-fluoride drinking water in Ethiopia. (15341618)
2004
17
Urinary fluoride levels and prevalence of dental fluorosis in children of Jhajjar District, Haryana. (14515029)
2003
18
Occurrence and management of dental fluorosis. (11697585)
2001
19
Dental fluorosis and caries experience in relation to three different drinking water fluoride levels in South Africa. (11572269)
2001
20
Weaning food and magadi associated with dental fluorosis in Northern Tanzania. (10809392)
2000
21
A review of fluoride dentifrice related to dental fluorosis. (10436482)
1999
22
Prevalence and severity of dental fluorosis in Al-Qaseem province--Kingdom of Saudi Arabia. (11372103)
1999
23
Caries and dental fluorosis in a 0.25 and a 2.5 ppm fluoride area in the Sudan. (9482041)
1997
24
Prevalence of dental caries and dental fluorosis in areas with optimal and above-optimal water fluoride concentrations: a 10-year follow-up survey. (7643332)
1995
25
Dental fluorosis: its use as a biomarker. (7993553)
1994
26
Strategies for improving the assessment of dental fluorosis: focus on optical techniques. (7993563)
1994
27
Epidemiologic indices for measuring the clinical manifestations of dental fluorosis: overview and critique. (7993559)
1994
28
Dental fluorosis and fluoride exposure in Western Australia. (2066481)
1991
29
Dental fluorosis following downward adjustment of fluoride in drinking water. (2072355)
1991
30
An new concept for removal of dental fluorosis stains. (1940756)
1991
31
Prevalence and severity of dental fluorosis in primary and permanent teeth at varying fluoride levels. (2640682)
1989
32
Epidemiological study on dental fluorosis and dental caries prevalence in communities with negligible, optimal, and above-optimal fluoride concentrations in drinking water supplies. (2486693)
1989
33
Dental fluorosis in children in the 1980s. A review of the literature. (3075187)
1988
34
Pediatric fluoride usage and dental fluorosis. (3271836)
1988
35
Effect of fluoride ingestion on dental fluorosis in sheep. (3592393)
1987
36
Trends in the prevalence of dental fluorosis in the United States: a review. (3553582)
1987
37
Patterns of dental fluorosis in a European country in relation to the fluoride concentration of drinking water. (3476536)
1987
38
Fluoride content of water, dust, soils and cereals in the endemic dental fluorosis area of Khouribga (Morocco). (3463255)
1986
39
Dental fluorosis in an area of Kenya with 2 ppm fluoride in the drinking water. (3457820)
1986
40
Prevalence of dental fluorosis in fluoridated and nonfluoridated communities--a preliminary investigation. (3465957)
1986
41
Concerning the pathogenesis of dental fluorosis. (3864418)
1985
42
Dental fluorosis--an esthetic problem. (3868657)
1985
43
Dose-response relationship between water fluoride levels and the category of questionable dental fluorosis. (6573236)
1983
44
Hypomineralization and increased porosity in dental fluorosis. (394037)
1979
45
Clinical appearance of dental fluorosis in permanent teeth in relation to histologic changes. (282114)
1978
46
Factors affecting the prevalence of dental fluorosis in Luknow, India. (4156909)
1974
47
Effect of a short period of fluoride ingestion on dental fluorosis in cattle. (5101849)
1971
48
Carnarvon studies. 3. Detailed investigations related to endemic dental fluorosis present in children in Carnarvon, Western Australia (August 1963). (5269074)
1970
49
Dental fluorosis and some other dental disorders in cattle and sheep. (5391507)
1969
50
Dental fluorosis and malnutrition. (13541259)
1958

Genetic Variations for Dental Fluorosis

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Expression for genes affiliated with Dental Fluorosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dental Fluorosis

Search GEO for disease gene expression data for Dental Fluorosis.

Pathways for genes affiliated with Dental Fluorosis

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53Reactome, 12EMD Millipore, 49PharmGKB, 51QIAGEN, 37NCBI BioSystems Database
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Compounds for genes affiliated with Dental Fluorosis

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Dental Fluorosis according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1xbai4410.1ESR2, COL1A2
2calcium carbonate4410.0BGLAP, DSPP
3thymol44 2810.9DSPP, AKR1A1
4carbodiimide449.9AKR1A1, COL1A2
5tartrate449.9BGLAP, DSPP
6fluoride449.8MMP20, DSPP, BGLAP
7sodium fluoride449.8BGLAP, DSPP
8rsai449.7ESR2, COL1A2, AKR1A1
9pyrazole44 1110.7AKR1A1, ESR2
10exemestane49 44 59 1112.6ESR2, BGLAP
11vitamin d449.5ESR2, DSPP, BGLAP, COL1A2
12polyglycolic acid449.4DSPP, AKR1A1, BGLAP
13guanidine hydrochloride449.4DSPP, BGLAP, AKR1A1
14sodium bicarbonate44 1110.4DSPP, AKR1A1
15h2o2448.8ESR2, AKR1A1, DSPP, BGLAP, TFPI
16serine448.1ESR2, KLK4, COL1A2, BGLAP, TFPI, AKR1A1

GO Terms for genes affiliated with Dental Fluorosis

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16Gene Ontology
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Cellular components related to Dental Fluorosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055788.8AMELY, AMELX, AMTN, DSPP, MMP20, MMP25
2extracellular regionGO:0055768.4KLK4, COL1A2, BGLAP, TFPI, ANGPTL6, MMP20

Biological processes related to Dental Fluorosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1amelogenesisGO:0971869.8MMP20, KLK4
2skeletal system developmentGO:0015019.6DSPP, BGLAP, COL1A2
3biomineral tissue developmentGO:0312149.5DSPP, AMTN, AMELX, AMELY

Molecular functions related to Dental Fluorosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of tooth enamelGO:03034510.1AMELX, AMELY
2hydroxyapatite bindingGO:0468489.5AMELX, BGLAP

Products for genes affiliated with Dental Fluorosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dental Fluorosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet