MCID: DNT001
MIFTS: 46

Dental Fluorosis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Fluorosis

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Aliases & Descriptions for Dental Fluorosis:

Name: Dental Fluorosis 10 12
Intrinsic Enamel Discolouration of Fluorosis 10
Dental Fluorosis, Acquired 65
 
Mottling of Enamel 10
Fluorosis, Dental 36
Mottled Teeth 10

Classifications:



External Ids:

Disease Ontology10 DOID:13711
ICD1027 K00.3
ICD9CM29 520.3
MeSH36 D009050
NCIt42 C85059
UMLS65 C0026618

Summaries for Dental Fluorosis

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Wikipedia:68 Dental fluorosis (also termed mottled enamel) is hypomineralization of tooth enamel caused by ingestion... more...

MalaCards based summary: Dental Fluorosis, also known as intrinsic enamel discolouration of fluorosis, is related to dental caries and caffey disease, and has symptoms including mucosal toxicity, opacity; enamel and teeth staining due to drugs. An important gene associated with Dental Fluorosis is COL1A2 (Collagen Type I Alpha 2), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. Affiliated tissues include breast, bone and prostate.

Related Diseases for Dental Fluorosis

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Diseases related to Dental Fluorosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1dental caries10.7
2caffey disease10.6BGLAP, COL1A2
3autosomal dominant microcephaly10.6COL1A2, DSPP
4osteogenesis imperfecta, type ii10.5BGLAP, COL1A2
5osteogenesis imperfecta, type iii10.5COL1A2, DSPP
6depressed scar10.5COL1A2, DSPP
7skin amelanotic melanoma10.4DSPP, ESR1
8chromosomal disease10.4BGLAP, ESR1
9bone development disease10.4BGLAP, ESR1
10deafness, autosomal dominant 8/1210.4ESR1, ESR2
11primary bacterial infectious disease10.4BGLAP, DSPP
12retroperitoneal sarcoma10.4ESR1, ESR2
13ankylosis10.4BGLAP, COL1A2
14sciatic neuropathy10.4ESR1, ESR2
15intraventricular meningioma10.4ESR1, ESR2
16suppurative thyroiditis10.4ESR1, ESR2
17breast granular cell tumor10.4ESR1, ESR2
18spinal meninges cancer10.4ESR1, ESR2
19small intestine leiomyosarcoma10.4ESR1, ESR2
20distal monosomy 9p10.3ESR1, ESR2
21progesterone-receptor negative breast cancer10.3ESR1, ESR2
22lymphadenitis10.3ESR1, ESR2
23photosensitive epilepsy10.3ESR1, ESR2
24estrogen-receptor negative breast cancer10.3ESR1, ESR2
25pelvic muscle wasting10.3AMBN, DSPP
26leptospirosis10.3ESR1, ESR2
27estrogen-receptor positive breast cancer10.2ESR1, ESR2
28oculoglandular tularemia10.2ESR1, ESR2
29anterior cruciate ligament tears10.2BGLAP, COL1A2, ESR1
30larynx sarcoma10.2ESR1, ESR2
31primary eye hypotony10.2COL1A2, DSPP
32periocular meningioma10.1ESR1, ESR2
33disease of mental health10.1ESR1, ESR2
34sclerosteosis10.1COL1A2, ESR1, ESR2
35asphyxiating thoracic dystrophy10.1COL1A2, DSPP, MMP20
36tracheal lymphoma10.1ESR1, ESR2
37thyroiditis10.0
38periodontitis10.0
39diabetes insipidus10.0
40bone ameloblastoma10.0AMBN, MMP20
41blepharochalasis10.0ESR1, ESR2
42anal fistula10.0AMBN, MMP20
43familial abdominal aortic aneurysm9.9BGLAP, TFG
44amelogenesis imperfecta9.9
45burns9.9
46dentin dysplasia9.9
47gingivitis9.9
48periodontal disease9.9
49taurodontism9.9
50solitary necrotic tumor of the liver9.8AMBN, DSPP, MMP20

Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to dental fluorosis

Symptoms for Dental Fluorosis

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UMLS symptoms related to Dental Fluorosis:


mucosal toxicity, opacity; enamel, teeth staining due to drugs, toothache

Drugs & Therapeutics for Dental Fluorosis

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Drugs for Dental Fluorosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Protective AgentsPhase 3, Phase 15651
2FluoridesPhase 3, Phase 1364
3Cariostatic AgentsPhase 3, Phase 1232
4
Calcium carbonateapprovedPhase 1194
Synonyms:
7 Select Antacid
Alka-seltzer Fruit Chews
Alka-seltzer Heartburn Reliefchews
Alka-seltzer Heartburn Reliefchews Cool Mint
Alka-seltzer Heartburn Reliefchews Strawberry
Antacid
Antacid Extra Strength Assorted Berries
Antacid Ultra Strength
Antacid Ultra Strength Assorted Berries
Antacid extra strength
Antacid maximum strength ultra
Being Well Antacid
CaCO3
Calcid ANTACID CALCIUM SUPPLEMENT REGULAR STRENGTH
Calcium Antacid
Calcium Antacid extra strength
Calcium Carbonate
Calcium Carbonate (Antacid)
Calcium Carbonate Chewable Antacid
Calcium Carbonate Extra Strength Antacid
Calcium carbonate
Calcium carbonate (1:1)
Calciumcarbonat
Carbonate de calcium
Carbonato de calcio
Carbonic acid calcium salt (1:1)
Care One Calcium Antacid
Childrens Chewable Antacid
Childrens Pepto
Childrens Stomach Relief
Chooz
D-cal
D-cal Kids
Dg Health Antacid Calcium Supplement
Dg Health Antacid Calcium Supplement regular strength
Dg Health Calcium Antacid
Dg Health Calcium Antacid extra strength
Equaline Antacid
Equaline Antacid regular strength
Equate Antacid
Equate Antacid regular strength
Exchange Select Calcium Antacid
Extra Strength
Extra Strength antacid calcium supplement
First Aid Shot Therapy Upset Stomach Relief
Formu Care Calcium Antacid
Good Sense Antacid
Green Guard Stomach Relief
Health Mart Calcium Antacid
Health Mart Calcium Antacid Assorted Fruit
 
Healthmart Calcium Antacid
Healthy Accents Antacid
Healthy Accents Antacid extra strength
Healthy Mama TAME THE FLAME
Heartburn Relief To Go
His Ulc Mint Blue
Kalziumkarbonat
Kirkland Signature Antacid
Kohlensaurer kalk
Leader Antacid
Leader Antacid Regular Strength
Maximum Strength
Medi First Antacid
Medi First Plus Antacid
Medi-first Antacid
Medi-first Plus Antacid
Medique Alcalak
Medique Ban-acid Maximum Strength 750
Meijer Softchews
Miralac
Miralac Antacid
Moore Medical Antacid
Nutralox
Physicianscare Antacid
Plus Pharma Calcium Antacid
Precipitated calcium carbonate
Regular Strength
Regular Strength Antacid Calcium Supplement
Rexall Antacid
Rx Act Antacid extra strength
Select Brand Antacid Assorted Berries
Sunmark Assorted Berries
Sunmark Calcium Antacid
Sunmark Calcium Antacid REGULAR STRENGTH
Sunmark Calcium Antacid extra strength
Sunmark Calcium Antacid regular strength
Sunmark Smooth Antacid
Titralac
Topcare Antacid Calcium
Topcare Antacid Calcium Extra Strength
Topcare Antacid Calcium Regular Strength
Topcare Antacid Calcium Ultra Strength
Trial Antacid
Tums
Tums Chewy Delights
Tums EX
Tums Smoothies
Tums ULTRA
Tums freshers
Ultrastrength
Welby Health Antacid
e 170
5Calcium, DietaryPhase 14678
6Gastrointestinal AgentsPhase 16401
7Pharmaceutical SolutionsPhase 17004
8Anti-Ulcer AgentsPhase 11453
9AntacidsPhase 11453
10ListerinePhase 1164
11sodium fluoridePhase 1164
12
Hydrogen peroxide467722-84-1784
Synonyms:
Adeka Super EL
Albone
Albone 35
Albone DS
Anti-Keim 50
Asepticper
Baquashock
CIX
Clarigel Gold
Crestal Whitestrips
Crystacide
Dentasept
Deslime LP
Hioxyl
Hipox
Hybrite
Hydrogen dioxide
Hydrogen peroxide
Inhibine
Lase Peroxide
Lensan A
 
Magic Bleaching
Metrokur
Mirasept
Nite White Excel 2
Odosat D
Opalescence Xtra
Oxigenal
Oxydol
Oxyfull
Oxysept
Oxysept I
Pegasyl
Perhydrol
Perone
Peroxaan
Peroxclean
Quasar Brite
Select Bleach
Superoxol
T-Stuff
Whiteness HP
Whitespeed
Xtra White
13
14Anti-Infective Agents17220
15Anti-Infective Agents, Local984

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effect of pH and Fluoride Concentration of Dentifrices on Caries ControlCompletedNCT01049503Phase 3
2Anticaries Potential and Fluorosis Risk From Different Fluoride ToothpastesCompletedNCT01589991Phase 1
3Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as AbrasivesCompletedNCT01571050Phase 1
4Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated WaterCompletedNCT01978041Phase 1
5Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis StainsCompletedNCT01733888
6Fluoride Intake From Toothbrushig With Children's or Regular ToothpastesCompletedNCT01568541

Search NIH Clinical Center for Dental Fluorosis


Cochrane evidence based reviews: fluorosis, dental

Genetic Tests for Dental Fluorosis

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Anatomical Context for Dental Fluorosis

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MalaCards organs/tissues related to Dental Fluorosis:

33
Breast, Bone, Prostate, Thyroid, Liver, Endothelial, Eye

Animal Models for Dental Fluorosis or affiliated genes

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Publications for Dental Fluorosis

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Articles related to Dental Fluorosis:

(show top 50)    (show all 423)
idTitleAuthorsYear
1
Dental fluorosis and urinary fluoride concentration as a reflection of fluoride exposure and its impact on IQ level and BMI of children of Laxmisagar, Simlapal Block of Bankura District, W.B., India. (26960765)
2016
2
Timing of fluoride intake and dental fluorosis on late-erupting permanent teeth. (26198477)
2015
3
Differential diagnosis of dental fluorosis made by undergraduate dental students. (26761552)
2015
4
Association between urine fluoride and dental fluorosis as a toxicity factor in a rural community in the state of San Luis Potosi. (25789336)
2015
5
Retention of fissure sealants in young permanent molars affected by dental fluorosis: a 12-month clinical study. (24737141)
2014
6
Minimally invasive treatment for esthetic management of severe dental fluorosis: a case report. (23210860)
2013
7
Reversal of dental fluorosis: A clinical study. (23633850)
2013
8
Prevalence and self perception of Dental Fluorosis among 15 year old school children in Prakasham district of south India. (24453447)
2013
9
Osteo-dental fluorosis in relation to chemical constituents of drinking waters. (23741872)
2012
10
Coal-burning roasted corn and chili as the cause of dental fluorosis for children in southwestern China. (21074315)
2011
11
The relationships between low levels of urine fluoride on children's intelligence, dental fluorosis in endemic fluorosis areas in Hulunbuir, Inner Mongolia, China. (21237562)
2011
12
Prevalence and severity of dental fluorosis in the United States, 1999-2004. (21211168)
2010
13
Considerations on optimal fluoride intake using dental fluorosis and dental caries outcomes--a longitudinal study. (19054310)
2009
14
Exposure to high fluoride drinking water and risk of dental fluorosis in Estonia. (19440411)
2009
15
Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis. (19425228)
2009
16
Risk factors associated with dental fluorosis in Central Plateau State, Nigeria. (18333878)
2008
17
Fluoride intake by children at risk for the development of dental fluorosis: comparison of regular dentifrices and flavoured dentifrices for children. (17823508)
2007
18
Dental fluorosis in cohorts born before, during, and after the national salt fluoridation program in a community in Mexico. (16829495)
2006
19
Prevalence of dental fluorosis in rural areas of Davangere, India. (15503846)
2004
20
Dental fluorosis and nutritional status of 6- to 11-year-old children living in rural areas of ParaA-ba, Brazil. (9831782)
1999
21
Fluoride exposure and dental fluorosis in Newburgh and Kingston, New York: policy implications. (10385354)
1999
22
Re: Vegetarianism and dental fluorosis among children in a high fluoride area of northern Tanzania (1999;9: 3-11) (10841607)
1999
23
Fluoride concentration in AgF and dental fluorosis. (9316315)
1997
24
Prevalence of dental caries and dental fluorosis in areas with optimal and above-optimal water fluoride concentrations: a 10-year follow-up survey. (7643332)
1995
25
Water fluoridation: current effectiveness and dental fluorosis. (8070242)
1994
26
Trends in prevalence of dental fluorosis in North America. (8070241)
1994
27
Dental fluorosis and fluoride exposure in Western Australia. (2066481)
1991
28
The severity of dental fluorosis in children exposed to water with a high fluoride content for various periods of time. (2045574)
1991
29
Differential diagnosis of dental fluorosis. (2179334)
1990
30
Re: A review of differential diagnosis of dental fluorosis and non-fluoride enamel defects. (2645022)
1989
31
Dental fluorosis in children in the 1980s. A review of the literature. (3075187)
1988
32
Dental caries and dental fluorosis. (3226636)
1988
33
Fluoride content of infant formulas: soy-based formulas as a potential factor in dental fluorosis. (3268804)
1988
34
Risk factors for dental fluorosis in a fluoridated community. (3198847)
1988
35
Effect of fluoride ingestion on dental fluorosis in sheep. (3592393)
1987
36
Fluoride content of water, dust, soils and cereals in the endemic dental fluorosis area of Khouribga (Morocco). (3463255)
1986
37
Posteruptive tooth age and severity of dental fluorosis in Kenya. (3492031)
1986
38
Dental fluorosis in bovine temporary teeth. (3994105)
1985
39
A new method for assessing the prevalence of dental fluorosis--the Tooth Surface Index of Fluorosis. (6611361)
1984
40
Chemical treatment of endemic dental fluorosis. (6955830)
1982
41
Caries and dental fluorosis in high-fluoride districts under sub-tropical conditions. (6943212)
1980
42
Bovine dental fluorosis: histologic and physical characteristics. (646194)
1978
43
An unusual incident of dental fluorosis: report of a case. (264940)
1977
44
Clinical and structural features and possible pathogenic mechanisms of dental fluorosis. (272716)
1977
45
Assessment of the fluoride content of water in wells selected randomly and after examining schoolchildren for dental fluorosis. (4546731)
1973
46
Occurrence of dental fluorosis in Australian aboriginal children resident in Carnarvon, Western Australia. (5270578)
1970
47
A note on dental fluorosis at Tristan da Cunha. (13429646)
1957
48
Dental fluorosis and water fluoridation. (13234849)
1955
49
Dental fluorosis. (20994695)
1946
50
Some Epidemiological Aspects of Chronic Endemic Dental Fluorosis. (18014440)
1936

Variations for Dental Fluorosis

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Expression for genes affiliated with Dental Fluorosis

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Search GEO for disease gene expression data for Dental Fluorosis.

Pathways for genes affiliated with Dental Fluorosis

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GO Terms for genes affiliated with Dental Fluorosis

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Biological processes related to Dental Fluorosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1Sertoli cell developmentGO:006000910.2ESR1, ESR2
2Sertoli cell proliferationGO:006001110.1ESR1, ESR2
3regulation of neuron apoptotic processGO:004352310.1ESR1, ESR2
4negative regulation of neuron deathGO:19012159.9ESR1, ESR2
5ossificationGO:00015039.9BGLAP, DSPP
6male gonad developmentGO:00085849.9ESR1, ESR2
7positive regulation of ERK1 and ERK2 cascadeGO:00703749.7ESR1, ESR2
8response to ethanolGO:00454719.7BGLAP, ESR2
9response to activityGO:00148239.7BGLAP, ESR2
10response to estrogenGO:00436279.4BGLAP, ESR1

Molecular functions related to Dental Fluorosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1core promoter sequence-specific DNA bindingGO:00010469.6ESR1, ESR2

Sources for Dental Fluorosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet