MCID: DNT001
MIFTS: 39

Dental Fluorosis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Fluorosis

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Aliases & Descriptions for Dental Fluorosis:

Name: Dental Fluorosis 10 12
Intrinsic Enamel Discolouration of Fluorosis 10
Dental Fluorosis, Acquired 65
 
Mottling of Enamel 10
Fluorosis, Dental 36
Mottled Teeth 10

Classifications:



External Ids:

Disease Ontology10 DOID:13711
ICD1027 K00.3
ICD9CM29 520.3
MeSH36 D009050
NCIt42 C85059
UMLS65 C0026618

Summaries for Dental Fluorosis

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Wikipedia:68 Dental fluorosis (also termed mottled enamel) is hypomineralization of tooth enamel caused by ingestion... more...

MalaCards based summary: Dental Fluorosis, also known as intrinsic enamel discolouration of fluorosis, is related to breast cancer and leukemia. An important gene associated with Dental Fluorosis is COL1A2 (Collagen Type I Alpha 2), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. Affiliated tissues include lung, liver and endothelial.

Related Diseases for Dental Fluorosis

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Diseases related to Dental Fluorosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 312)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer10.5
2leukemia10.4
3adenocarcinoma10.4
4neuronitis10.4
5caffey disease10.4BGLAP, COL1A2
6autosomal dominant microcephaly10.4COL1A2, DSPP
7osteogenesis imperfecta, type ii10.4BGLAP, COL1A2
8osteogenesis imperfecta, type iii10.3COL1A2, DSPP
9depressed scar10.3COL1A2, DSPP
10gastric cancer10.3
11hepatitis10.3
12lymphoma10.3
13thyroiditis10.3
14skin amelanotic melanoma10.3DSPP, ESR1
15chromosomal disease10.3BGLAP, ESR1
16bone development disease10.3BGLAP, ESR1
17deafness, autosomal dominant 8/1210.3ESR1, ESR2
18primary bacterial infectious disease10.3BGLAP, DSPP
19retroperitoneal sarcoma10.3ESR1, ESR2
20lung cancer10.3
21hepatocellular carcinoma10.3
22asthma10.3
23prostatitis10.3
24dermatitis10.3
25atopic dermatitis10.3
26cerebritis10.3
27meningitis10.3
28endotheliitis10.3
29ankylosis10.3BGLAP, COL1A2
30sciatic neuropathy10.3ESR1, ESR2
31intraventricular meningioma10.2ESR1, ESR2
32suppurative thyroiditis10.2ESR1, ESR2
33breast granular cell tumor10.2ESR1, ESR2
34spinal meninges cancer10.2ESR1, ESR2
35small intestine leiomyosarcoma10.2ESR1, ESR2
36distal monosomy 9p10.2ESR1, ESR2
37progesterone-receptor negative breast cancer10.2ESR1, ESR2
38lymphadenitis10.2ESR1, ESR2
39photosensitive epilepsy10.2ESR1, ESR2
40estrogen-receptor negative breast cancer10.2ESR1, ESR2
41pelvic muscle wasting10.2AMBN, DSPP
42leptospirosis10.2ESR1, ESR2
43schizophrenia10.2
44colorectal cancer10.2
45hiv-110.2
46obesity10.2
47hepatitis b10.2
48liver cirrhosis10.2
49spinal muscular atrophy10.2
50thalassemia10.2

Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to dental fluorosis

Symptoms for Dental Fluorosis

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Drugs & Therapeutics for Dental Fluorosis

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Drugs for Dental Fluorosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Protective AgentsPhase 3, Phase 15651
2FluoridesPhase 3, Phase 1364
3Cariostatic AgentsPhase 3, Phase 1232
4
Calcium carbonateapprovedPhase 1194
Synonyms:
7 Select Antacid
Alka-seltzer Fruit Chews
Alka-seltzer Heartburn Reliefchews
Alka-seltzer Heartburn Reliefchews Cool Mint
Alka-seltzer Heartburn Reliefchews Strawberry
Antacid
Antacid Extra Strength Assorted Berries
Antacid Ultra Strength
Antacid Ultra Strength Assorted Berries
Antacid extra strength
Antacid maximum strength ultra
Being Well Antacid
CaCO3
Calcid ANTACID CALCIUM SUPPLEMENT REGULAR STRENGTH
Calcium Antacid
Calcium Antacid extra strength
Calcium Carbonate
Calcium Carbonate (Antacid)
Calcium Carbonate Chewable Antacid
Calcium Carbonate Extra Strength Antacid
Calcium carbonate
Calcium carbonate (1:1)
Calciumcarbonat
Carbonate de calcium
Carbonato de calcio
Carbonic acid calcium salt (1:1)
Care One Calcium Antacid
Childrens Chewable Antacid
Childrens Pepto
Childrens Stomach Relief
Chooz
D-cal
D-cal Kids
Dg Health Antacid Calcium Supplement
Dg Health Antacid Calcium Supplement regular strength
Dg Health Calcium Antacid
Dg Health Calcium Antacid extra strength
Equaline Antacid
Equaline Antacid regular strength
Equate Antacid
Equate Antacid regular strength
Exchange Select Calcium Antacid
Extra Strength
Extra Strength antacid calcium supplement
First Aid Shot Therapy Upset Stomach Relief
Formu Care Calcium Antacid
Good Sense Antacid
Green Guard Stomach Relief
Health Mart Calcium Antacid
Health Mart Calcium Antacid Assorted Fruit
 
Healthmart Calcium Antacid
Healthy Accents Antacid
Healthy Accents Antacid extra strength
Healthy Mama TAME THE FLAME
Heartburn Relief To Go
His Ulc Mint Blue
Kalziumkarbonat
Kirkland Signature Antacid
Kohlensaurer kalk
Leader Antacid
Leader Antacid Regular Strength
Maximum Strength
Medi First Antacid
Medi First Plus Antacid
Medi-first Antacid
Medi-first Plus Antacid
Medique Alcalak
Medique Ban-acid Maximum Strength 750
Meijer Softchews
Miralac
Miralac Antacid
Moore Medical Antacid
Nutralox
Physicianscare Antacid
Plus Pharma Calcium Antacid
Precipitated calcium carbonate
Regular Strength
Regular Strength Antacid Calcium Supplement
Rexall Antacid
Rx Act Antacid extra strength
Select Brand Antacid Assorted Berries
Sunmark Assorted Berries
Sunmark Calcium Antacid
Sunmark Calcium Antacid REGULAR STRENGTH
Sunmark Calcium Antacid extra strength
Sunmark Calcium Antacid regular strength
Sunmark Smooth Antacid
Titralac
Topcare Antacid Calcium
Topcare Antacid Calcium Extra Strength
Topcare Antacid Calcium Regular Strength
Topcare Antacid Calcium Ultra Strength
Trial Antacid
Tums
Tums Chewy Delights
Tums EX
Tums Smoothies
Tums ULTRA
Tums freshers
Ultrastrength
Welby Health Antacid
e 170
5Calcium, DietaryPhase 14678
6Gastrointestinal AgentsPhase 16401
7Pharmaceutical SolutionsPhase 17004
8Anti-Ulcer AgentsPhase 11453
9AntacidsPhase 11453
10ListerinePhase 1164
11sodium fluoridePhase 1164
12
Hydrogen peroxide467722-84-1784
Synonyms:
Adeka Super EL
Albone
Albone 35
Albone DS
Anti-Keim 50
Asepticper
Baquashock
CIX
Clarigel Gold
Crestal Whitestrips
Crystacide
Dentasept
Deslime LP
Hioxyl
Hipox
Hybrite
Hydrogen dioxide
Hydrogen peroxide
Inhibine
Lase Peroxide
Lensan A
 
Magic Bleaching
Metrokur
Mirasept
Nite White Excel 2
Odosat D
Opalescence Xtra
Oxigenal
Oxydol
Oxyfull
Oxysept
Oxysept I
Pegasyl
Perhydrol
Perone
Peroxaan
Peroxclean
Quasar Brite
Select Bleach
Superoxol
T-Stuff
Whiteness HP
Whitespeed
Xtra White
13
14Anti-Infective Agents17220
15Anti-Infective Agents, Local984

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effect of pH and Fluoride Concentration of Dentifrices on Caries ControlCompletedNCT01049503Phase 3
2Anticaries Potential and Fluorosis Risk From Different Fluoride ToothpastesCompletedNCT01589991Phase 1
3Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as AbrasivesCompletedNCT01571050Phase 1
4Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated WaterCompletedNCT01978041Phase 1
5Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis StainsCompletedNCT01733888
6Fluoride Intake From Toothbrushig With Children's or Regular ToothpastesCompletedNCT01568541

Search NIH Clinical Center for Dental Fluorosis


Cochrane evidence based reviews: fluorosis, dental

Genetic Tests for Dental Fluorosis

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Anatomical Context for Dental Fluorosis

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MalaCards organs/tissues related to Dental Fluorosis:

33
Lung, Liver, Endothelial, Breast, B cells, Prostate, T cells

Animal Models for Dental Fluorosis or affiliated genes

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Publications for Dental Fluorosis

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Articles related to Dental Fluorosis:

(show top 50)    (show all 415)
idTitleAuthorsYear
1
Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous Pemphigoid. (26346226)
2015
2
Asthma characteristics among older adults: using the California health interview survey to examine asthma incidence, morbidity, and ethnic differences. (24432869)
2014
3
Expression of L-type amino acid transporter 1 (LAT1) as a prognostic and therapeutic indicator in multiple myeloma. (25220100)
2014
4
Cerebral oedema is rare in acute-on-chronic liver failure patients presenting with high-grade hepatic encephalopathy. (23844567)
2013
5
Type I interferon imposes a TSG101/ISG15 checkpoint at the Golgi for glycoprotein trafficking during influenza virus infection. (24237697)
2013
6
The SLC26 gene family of anion transporters and channels. (23506885)
2013
7
Clinical significance of pretreatment plasma biomarkers in advanced non-small cell lung cancer patients. (24378285)
2013
8
Acute aortoiliac thrombotic occlusion in an infant with protein C deficiency and small atrial sepal defect--a rare case. (23480928)
2013
9
High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions. (24380696)
2013
10
Cytokine gene polymorphisms in Tunisian endemic pemphigus foliaceus: a possible role of il-4 variants. (23376457)
2013
11
Plasma levels of FABP4, but not FABP3, are associated with increased risk of diabetes. (22706792)
2012
12
Podoconiosis in East and West Gojam Zones, northern Ethiopia. (22816005)
2012
13
Maternal knowledge, attitudes and beliefs regarding gastroenteritis and rotavirus vaccine before implementing vaccination program: which key messages in light of a new immunization program? (22858556)
2012
14
Tumor necrosis factor promoter polymorphism TNF*-857 is a risk allele for psoriatic arthritis independent of the PSORS1 locus. (22127698)
2011
15
Intraventricular hemorrhage as an unusual presenting form of Sneddon syndrome. (20849802)
2010
16
Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway. (18996613)
2009
17
Binding of lopinavir to human alpha1-acid glycoprotein and serum albumin. (19439488)
2009
18
Videomanometric evaluation of pharyngo-oesophageal dysmotility in children with velocardiofacial syndrome. (18162840)
2008
19
Insulin-inhibited and stimulated cultured vascular smooth muscle cell migration are related to divergent effects on protein phosphatase-2A and autonomous calcium/calmodulin-dependent protein kinase II. (17553505)
2008
20
Infliximab]. (19080986)
2008
21
Speech and language development in cri du chat syndrome: a critical review. (18484284)
2008
22
Diagnosis of remitting seronegative symmetrical synovitis with pitting edema in a patient with sarcoidosis: comment on the article by Dejaco et al. (18821659)
2008
23
The spectrum of focal segmental glomerulosclerosis: new insights. (18408478)
2008
24
Chromosomal localization of nine porcine genes encoding transcription factors involved in adipogenesis. (18544926)
2008
25
Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla. (18707679)
2008
26
A novel calmodulin-Ca2+ target recognition activates the Bcl-2 regulator FKBP38. (17942410)
2007
27
Identification and in silico analyses of novel TGFBR1 and TGFBR2 mutations in Marfan syndrome-related disorders. (16791849)
2006
28
Treatment of adductor spasmodic dysphonia with selective laryngeal adductor denervation and reinnervation surgery. (16469658)
2006
29
Direct association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with Type 2 diabetes mellitus and insulin resistance. (16911630)
2006
30
Direct effect of progestogen on gene expression in the testis during gonadotropin withdrawal and early suppression of spermatogenesis. (16621906)
2006
31
Prevalence of vitamin B12 deficiency in patients with plasma cell dyscrasias. (15937914)
2005
32
Predictive molecular marker of distant metastasis in colorectal cancer]. (15027705)
2003
33
Impairment of energy metabolism in hippocampus of rats subjected to chemically-induced hyperhomocysteinemia. (12697299)
2003
34
Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS. (12213447)
2002
35
Heat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCs. (11884472)
2002
36
Effects of ventriculoperitoneal shunt removal on cerebral oxygenation and brain compliance in chronic obstructive hydrocephalus. (11302655)
2001
37
Recombinant thrombomodulin inhibits thrombin-induced vascular endothelial growth factor production in neuronal cells. (10844408)
1999
38
Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily. (8905447)
1996
39
Phosphorylated Ser/Arg-rich proteins: limiting factors in the assembly of 200S large nuclear ribonucleoprotein particles. (8799112)
1996
40
Correlation of nocturnal increase in plasma oxytocin with a decrease in plasma estradiol/progesterone ratio in late pregnancy. (1471665)
1992
41
Neuronal-astrocytic interactions in brain development, brain function and brain disease. (1664174)
1991
42
Idiopathic blepharospasm-oromandibular dystonia syndrome (Meige's syndrome) presenting as chronic temporomandibular joint dislocation. (2049364)
1991
43
Overnutrition: an epidemic problem in pet animal practice? (2658284)
1989
44
Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin. (3169987)
1988
45
Computed tomography and sonography of cystic adventitial disease. (3530360)
1986
46
Discoid lupus erythematosus-like skin lesions in a patient with autosomal recessive chronic granulomatous disease. (3780033)
1986
47
Neuroendocrine carcinomas of the larynx. A study of two types, one of which mimics thyroid medullary carcinoma. (2866724)
1985
48
Synthesis and catabolism of PGE2 by a nephroblastoma associated with hypercalcemia without bone metastases. (6331625)
1984
49
PROGNOSTIC VALUE OF 24-HOUR RADIOACTIVE IODINE UPTAKE; STUDIES IN PATIENTS WITH NODULAR GOITER AND DIFFUSE HYPERPLASTIC GOITER EIGHT TO TEN WEEKS FOLLOWING THERAPY WITH RADIOIODINE (I 131). (14160118)
1964
50
Clinical observations in patients with myoma of the uterus with particular regard to changes in size and indications for surgery. (13207235)
1954

Variations for Dental Fluorosis

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Expression for genes affiliated with Dental Fluorosis

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Search GEO for disease gene expression data for Dental Fluorosis.

Pathways for genes affiliated with Dental Fluorosis

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GO Terms for genes affiliated with Dental Fluorosis

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Biological processes related to Dental Fluorosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1Sertoli cell developmentGO:006000910.2ESR1, ESR2
2Sertoli cell proliferationGO:006001110.1ESR1, ESR2
3regulation of neuron apoptotic processGO:004352310.1ESR1, ESR2
4negative regulation of neuron deathGO:19012159.9ESR1, ESR2
5ossificationGO:00015039.9BGLAP, DSPP
6male gonad developmentGO:00085849.9ESR1, ESR2
7positive regulation of ERK1 and ERK2 cascadeGO:00703749.7ESR1, ESR2
8response to ethanolGO:00454719.7BGLAP, ESR2
9response to activityGO:00148239.7BGLAP, ESR2
10response to estrogenGO:00436279.4BGLAP, ESR1

Molecular functions related to Dental Fluorosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1core promoter sequence-specific DNA bindingGO:00010469.6ESR1, ESR2

Sources for Dental Fluorosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet