MCID: DNT001
MIFTS: 44

Dental Fluorosis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Fluorosis

MalaCards integrated aliases for Dental Fluorosis:

Name: Dental Fluorosis 12 72 14
Intrinsic Enamel Discolouration of Fluorosis 12
Dental Fluorosis, Acquired 69
Mottling of Enamel 12
Fluorosis, Dental 41
Mottled Teeth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13711
ICD10 32 K00.3
ICD9CM 34 520.3
MeSH 41 D009050
NCIt 46 C85059
UMLS 69 C0026618

Summaries for Dental Fluorosis

MalaCards based summary : Dental Fluorosis, also known as intrinsic enamel discolouration of fluorosis, is related to dental caries and ehlers-danlos syndrome, classic type, 1, and has symptoms including toothache An important gene associated with Dental Fluorosis is COL1A2 (Collagen Type I Alpha 2 Chain), and among its related pathways/superpathways are Degradation of the extracellular matrix and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Fluorides and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and testes.

Wikipedia : 72 Dental fluorosis (also termed mottled enamel) is an extremely common disorder, characterized by... more...

Related Diseases for Dental Fluorosis

Diseases related to Dental Fluorosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 dental caries 30.5 AMELX DSPP
2 ehlers-danlos syndrome, classic type, 1 10.3 COL1A2 DSPP
3 aromatase deficiency 10.3 BGLAP ESR1
4 aging 10.3
5 osteogenesis imperfecta, type iv 10.3 COL1A2 DSPP
6 endometrial disease 10.3 DSPP ESR1
7 osteogenesis imperfecta, type i 10.3 BGLAP COL1A2
8 dentinogenesis imperfecta 10.3 COL1A2 DSPP
9 osteogenesis imperfecta, type iii 10.3 BGLAP COL1A2
10 bone resorption disease 10.3 BGLAP ESR1
11 progesterone resistance 10.2 ESR1 ESR2
12 postmenopausal atrophic vaginitis 10.2 ESR1 ESR2
13 progesterone-receptor positive breast cancer 10.2 ESR1 ESR2
14 bone remodeling disease 10.2 BGLAP ESR1
15 gender identity disorder 10.2 ESR1 ESR2
16 spinal stenosis 10.2 COL1A2 TIMP1
17 estrogen excess 10.2 ESR1 ESR2
18 endometriosis of ovary 10.2 ESR1 ESR2
19 vaginitis 10.2 ESR1 ESR2
20 lobular neoplasia 10.2 ESR1 ESR2
21 mungan syndrome 10.2
22 pelvic organ prolapse 10.2 ESR1 ESR2
23 brittle bone disorder 10.2 BGLAP COL1A2 DSPP
24 hypocalcified amelogenesis imperfecta 10.1 DSPP MMP20
25 hypophosphatemia 10.1 BGLAP DSPP
26 thyroiditis 10.1
27 leiomyoma, uterine 10.1 ESR1 ESR2
28 idiopathic scoliosis 10.0 COL1A2 ESR1 ESR2
29 female reproductive system disease 10.0 ESR1 ESR2
30 dermal ridges-off-the-end 10.0
31 burns 10.0
32 periodontitis 10.0
33 diabetes insipidus 10.0
34 dental pulp necrosis 10.0 AMELX DSPP
35 tooth resorption 10.0 AMELX DSPP
36 dental pulp disease 10.0 AMELX DSPP
37 tooth agenesis 9.9 COL1A2 DSPP MMP20
38 sporadic breast cancer 9.9 ESR1 ESR2
39 beta-adrenergic stimulation, response to 9.8
40 taurodontism 9.8
41 body mass index quantitative trait locus 1 9.8
42 kashin-beck disease 9.8
43 amelogenesis imperfecta 9.8
44 dentin dysplasia 9.8
45 allergic hypersensitivity disease 9.8
46 gingivitis 9.8
47 periodontal disease 9.8
48 amelogenesis imperfecta, type iiia 9.8 AMELX MMP20
49 amelogenesis imperfecta hypomaturation type 9.8 AMELX MMP20
50 osteoporosis 9.8 BGLAP COL1A2 ESR1 ESR2

Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to Dental Fluorosis

Symptoms & Phenotypes for Dental Fluorosis

UMLS symptoms related to Dental Fluorosis:


toothache

Drugs & Therapeutics for Dental Fluorosis

Drugs for Dental Fluorosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fluorides Phase 3,Phase 1
2 Protective Agents Phase 3,Phase 1
3 Cariostatic Agents Phase 3,Phase 1
4 sodium fluoride Approved Phase 1 7681-49-4
5
Calcium Carbonate Approved, Investigational Phase 1 471-34-1
6 Gastrointestinal Agents Phase 1
7 Antacids Phase 1
8 Pharmaceutical Solutions Phase 1
9 Anti-Ulcer Agents Phase 1
10 Listerine Phase 1
11 Calcium, Dietary Phase 1
12
Ethanol Approved 64-17-5 702
13
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
14 Immunoconjugates
15 Anti-Infective Agents
16 Anti-Infective Agents, Local
17 Bone Density Conservation Agents
18 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of pH and Fluoride Concentration of Dentifrices on Caries Control Completed NCT01049503 Phase 3
2 Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes Completed NCT01589991 Phase 1 Toothpaste
3 Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as Abrasives Completed NCT01571050 Phase 1 Purified water;Fresh MFP/CaCO3 toothpaste;Fresh NaF/SiO2 toothpaste;Aged NaF/SiO2 toothpaste;Aged MFP/CaCO3 toothpaste
4 Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated Water Completed NCT01978041 Phase 1
5 Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains Completed NCT01733888
6 Fluoride Intake From Toothbrushig With Children's or Regular Toothpastes Completed NCT01568541 Regular toothpastes;Children's toothpastes
7 Treatment of Hypersensitivity Using Diode Laser and Desensitising Agent on Fluorosed and Non-fluorosed Teeth Completed NCT03237793
8 Using Eggshell Calcium to Mitigate Fluorosis in Ethiopia Recruiting NCT03355222
9 Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits Active, not recruiting NCT02958891
10 Action of Infiltration Resin Icon in Fluorosis, Clinical Trial, Monitoring for 12 Month Not yet recruiting NCT02925780

Search NIH Clinical Center for Dental Fluorosis

Cochrane evidence based reviews: fluorosis, dental

Genetic Tests for Dental Fluorosis

Anatomical Context for Dental Fluorosis

MalaCards organs/tissues related to Dental Fluorosis:

38
Bone, Thyroid, Testes, Kidney, Brain

Publications for Dental Fluorosis

Articles related to Dental Fluorosis:

(show top 50) (show all 454)
# Title Authors Year
1
Comparative Analysis of Gene Expression Profiles of Human Dental Fluorosis and Kashin-Beck Disease. ( 29317700 )
2018
2
Impact of caries and dental fluorosis on oral health-related quality of life: a cross-sectional study in schoolchildren receiving water naturally fluoridated at above-optimal levels. ( 28251432 )
2017
3
Impact of Dental Fluorosis, Socioeconomic Status and Self-Perception in Adolescents Exposed to a High Level of Fluoride in Water. ( 28085102 )
2017
4
High prevalence of dental fluorosis among adolescents is a growing concern: a school based cross-sectional study from Southern India. ( 29165120 )
2017
5
A comparison of various minimally invasive techniques for the removal of dental fluorosis stains in children. ( 28762354 )
2017
6
High prevalence of dental fluorosis among schoolchildren in three villages in Vavuniya District: an observational study ( 29390597 )
2017
7
Dental fluorosis, nutritional status, kidney damage, and thyroid function along with bone metabolic indicators in school-going children living in fluoride-affected hilly areas of Doda district, Jammu and Kashmir, India. ( 29063198 )
2017
8
Factors affecting dental fluorosis in low socioeconomic status children in Mexico. ( 28573833 )
2017
9
Polymorphisms in genes involved in enamel development are associated with dental fluorosis. ( 28131910 )
2017
10
The effect of elemental content on the risk of dental fluorosis and the exposure of the environment and population to fluoride produced by coal-burning. ( 29101881 )
2017
11
Microabrasion-remineralization (MAb-Re): An innovative approach for dental fluorosis. ( 28914255 )
2017
12
Polymorphisms in Nonamelogenin Enamel Matrix Genes Are Associated with Dental Fluorosis. ( 29207377 )
2017
13
Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways. ( 27871895 )
2017
14
Risk factors and prevalence of dental fluorosis and dental caries in school children of North India. ( 28025807 )
2017
15
Prevalence of dental fluorosis in Mexico 2005-2015: a literature review. ( 28902318 )
2017
16
LS8 cell apoptosis induced by NaF through p-ERK and p-JNK - a mechanism study of dental fluorosis. ( 27624793 )
2016
17
Dietary Fluoride Intake and Associated Skeletal and Dental Fluorosis in School Age Children in Rural Ethiopian Rift Valley. ( 27472351 )
2016
18
Is there an association between the presence of dental fluorosis and dental trauma amongst school children? ( 26960108 )
2016
19
Chronic Exposure to Bisphenol A Exacerbates Dental Fluorosis in Growing Rats. ( 27257137 )
2016
20
Fluoride Varnish Applications in Preschoolers and Dental Fluorosis in Permanent Incisors: Results of a Nested-cohort Study Within a Clinical Trial. ( 28206898 )
2016
21
Dental fluorosis and urinary fluoride concentration as a reflection of fluoride exposure and its impact on IQ level and BMI of children of Laxmisagar, Simlapal Block of Bankura District, W.B., India. ( 26960765 )
2016
22
Dental fluorosis, fluoride in urine, and nutritional status in adolescent students living in the rural areas of Guanajuato, Mexico. ( 28032042 )
2016
23
Validation of ICMR index for identification of dental fluorosis in epidemiological studies. ( 27834326 )
2016
24
Natural history and long-term impact of dental fluorosis: a prospective cohort study. ( 26763813 )
2016
25
Prevalence of Dental Fluorosis and associated Risk Factors in Bagalkot District, Karnataka, India. ( 27843259 )
2016
26
The prevalence of dental fluorosis and exposure to fluoride in drinking water: A systematic review. ( 27651877 )
2016
27
Independent and Additive Effects of Different Sources of Fluoride and Dental Fluorosis. ( 27306248 )
2016
28
Prevalence and severity of dental fluorosis in four English cities. ( 28537367 )
2016
29
The prevalence of dental fluorosis and its associated factors in Salem district. ( 27307668 )
2016
30
Dental Fluorosis and Catalase Immunoreactivity of the Brain Tissues in Rats Exposed to High Fluoride Pre- and Postnatally. ( 27052310 )
2016
31
Grading and quantification of dental fluorosis in zebrafish larva. ( 27300491 )
2016
32
Enzymatic Activity of Glutathione S-Transferase and Dental Fluorosis Among Children Receiving Two Different Levels of Naturally Fluoridated Water. ( 27449362 )
2016
33
Application of quantitative light-induced fluorescence to determine the depth of demineralization of dental fluorosis in enamel microabrasion: a case report. ( 27508165 )
2016
34
Prevalence of dental fluorosis among primary school children in association with different water fluoride levels in Mysore district, Karnataka. ( 27237204 )
2016
35
Caries with Dental Fluorosis and Oral Health Behaviour Among 12-Year School Children in Moderate-Fluoride Drinking Water Community in Quetta, Pakistan. ( 27671177 )
2016
36
Correction: Methodological discussion about prevalence of the dental fluorosis on dental health surveys. ( 26153681 )
2015
37
Evaluation of Fluoride Retention Due to Most Commonly Consumed Estuarine Fishes Among Fish Consuming Population of Andhra Pradesh as a Contributing Factor to Dental Fluorosis: A Cross-Sectional Study. ( 26266208 )
2015
38
Dental fluorosis and its influence on children's life. ( 25590503 )
2015
39
Association of Temporomandibular Joint Signs & Symptoms with Dental Fluorosis & Skeletal Manifestations in Endemic Fluoride Areas of Dungarpur District, Rajasthan, India. ( 26816986 )
2015
40
Dental fluorosis and skeletal fluoride content as biomarkers of excess fluoride exposure in marsupials. ( 26188404 )
2015
41
Severe dental fluorosis and cognitive deficits. ( 25576911 )
2015
42
Collagenase 1A2 (COL1A2) gene A/C polymorphism in relation to severity of dental fluorosis. ( 26564713 )
2015
43
Nutritional status and dental fluorosis among schoolchildren in communities with different drinking water fluoride concentrations in a central region in Mexico. ( 26426374 )
2015
44
Dental fluorosis: prevalence and associated factors in 12-year-old schoolchildren in GoiAcnia, GoiA!s. ( 26247182 )
2015
45
Timing of fluoride intake and dental fluorosis on late-erupting permanent teeth. ( 26198477 )
2015
46
Fluoride Exposure Effects and Dental Fluorosis in Children in Mexico City. ( 26609898 )
2015
47
DENTAL FLUOROSIS AND ITS RELATION TO SOCIOECONOMIC STATUS, PARENTS' KNOWLEDGE AND AWARENESS AMONG 12-YEAR-OLD SCHOOL CHILDREN IN QUETTA, PAKISTAN. ( 26513940 )
2015
48
Dental fluorosis: A histological study using Light and Confocal microscopy. ( 26275189 )
2015
49
Differential diagnosis of dental fluorosis made by undergraduate dental students. ( 26761552 )
2015
50
Adult perceptions of dental fluorosis and select dental conditions-an Asian perspective. ( 26564646 )
2015

Variations for Dental Fluorosis

Expression for Dental Fluorosis

Search GEO for disease gene expression data for Dental Fluorosis.

Pathways for Dental Fluorosis

GO Terms for Dental Fluorosis

Cellular components related to Dental Fluorosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 AMELX BGLAP COL1A2 DSPP ESR2 MMP20
2 endoplasmic reticulum lumen GO:0005788 9.26 AMELX BGLAP COL1A2 TIMP1
3 proteinaceous extracellular matrix GO:0005578 9.02 AMELX COL1A2 DSPP MMP20 TIMP1

Biological processes related to Dental Fluorosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 odontogenesis GO:0042476 9.26 BGLAP COL1A2
2 intracellular estrogen receptor signaling pathway GO:0030520 9.16 ESR1 ESR2
3 skeletal system development GO:0001501 9.13 BGLAP COL1A2 DSPP
4 biomineral tissue development GO:0031214 8.8 AMELX BGLAP DSPP

Molecular functions related to Dental Fluorosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.76 ESR1 ESR2 MMP20 TIMP1
2 steroid hormone receptor activity GO:0003707 9.43 ESR1 ESR2
3 core promoter sequence-specific DNA binding GO:0001046 9.4 ESR1 ESR2
4 nuclear receptor activity GO:0004879 9.37 ESR1 ESR2
5 steroid binding GO:0005496 9.32 ESR1 ESR2
6 estrogen receptor activity GO:0030284 9.26 ESR1 ESR2
7 estrogen response element binding GO:0034056 9.16 ESR1 ESR2
8 hydroxyapatite binding GO:0046848 8.96 AMELX BGLAP
9 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2

Sources for Dental Fluorosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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