MCID: DNT001
MIFTS: 42

Dental Fluorosis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Fluorosis

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Aliases & Descriptions for Dental Fluorosis:

Name: Dental Fluorosis 11 13
Intrinsic Enamel Discolouration of Fluorosis 11
Dental Fluorosis, Acquired 66
 
Mottling of Enamel 11
Fluorosis, Dental 37
Mottled Teeth 11

Classifications:



External Ids:

Disease Ontology11 DOID:13711
ICD1028 K00.3
ICD9CM30 520.3
MeSH37 D009050
NCIt43 C85059

Summaries for Dental Fluorosis

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Wikipedia:69 Dental fluorosis (also termed mottled enamel)is an extremely common disorder, characterized by... more...

MalaCards based summary: Dental Fluorosis, also known as intrinsic enamel discolouration of fluorosis, is related to dental caries and mental retardation, autosomal recessive 35, and has symptoms including toothache, teeth staining due to drugs and opacity; enamel. An important gene associated with Dental Fluorosis is COL1A2 (Collagen Type I Alpha 2 Chain), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. Affiliated tissues include bone, thyroid and testes.

Related Diseases for Dental Fluorosis

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Diseases related to Dental Fluorosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1dental caries10.7
2mental retardation, autosomal recessive 3510.5BGLAP, COL1A2
3dyscalculia10.5BGLAP, COL1A2
4osteogenesis imperfecta, type ii10.5BGLAP, COL1A2
5aromatase excess syndrome10.5BGLAP, ESR1
6osteogenesis imperfecta, type iii10.4COL1A2, DSPP
7deafness, autosomal dominant 8/1210.4ESR1, ESR2
8her2-receptor positive breast cancer10.4ESR1, ESR2
9botulism10.4ESR1, ESR2
10diabetic foot ulcers10.4COL1A2, DSPP
11riedel's fibrosing thyroiditis10.4ESR1, ESR2
12retroperitoneum carcinoma10.4ESR1, ESR2
13allergic cutaneous vasculitis10.4ESR1, ESR2
14bone deterioration disease10.4BGLAP, ESR1
15breast malignant phyllodes tumor10.4ESR1, ESR2
16ocular cancer10.4ESR1, ESR2
17small intestinal sarcoma10.3ESR1, ESR2
18esophageal duplication cyst10.3DSPP, MMP20
19lateral sclerosis10.3ESR1, ESR2
20vulvovaginal candidiasis10.2BGLAP, COL1A2
21sclerocornea10.2ESR1, ESR2
22pineal region meningioma10.2ESR1, ESR2
23nodular degeneration of cornea10.1ESR1, ESR2
24physical disorder10.1BGLAP, ESR1, ESR2
25airway-centered interstitial fibrosis10.1AMELX, MMP20
26thyroiditis10.0
27periodontitis10.0
28diabetes insipidus10.0
29candidiasis10.0ESR1, ESR2
30prostate cancer, hereditary, x-linked 110.0ESR1, ESR2
31enamel caries10.0AMELX, DSPP
32anaplastic large cell lymphoma9.9AMELX, MMP20
33septicemic plague9.9ESR1, ESR2
34taurodontism9.9
35amelogenesis imperfecta9.9
36burns9.9
37dentin dysplasia9.9
38gingivitis9.9
39periodontal disease9.9
40anterograde amnesia9.8AMELX, AMELY
41uremia9.8AMELX, AMELY
42myxedema9.8AMELX, AMELY
43chylomicron retention disease9.8BGLAP, COL1A2, ESR1, ESR2
44breast myoepitheliosis9.7AMELX, AMELY
45capillary disease9.7ESR1, ESR2
46polyneuropathy in collagen vascular disease9.7AMELX, AMELY
47breast adenomyoepithelioma9.7AMELX, AMELY
48bone squamous cell carcinoma9.7AMELX, AMELY
49pneumatosis cystoides intestinalis9.4AMELX, AMELY, DSPP
50paraphimosis9.4AMELX, AMELY, DSPP

Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to dental fluorosis

Symptoms for Dental Fluorosis

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UMLS symptoms related to Dental Fluorosis:


toothache, teeth staining due to drugs, opacity; enamel, mucosal toxicity

Drugs & Therapeutics for Dental Fluorosis

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Drugs for Dental Fluorosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1FluoridesPhase 3, Phase 1405
2sodium fluoridePhase 11787681-49-4
3
Calcium carbonatePhase 1202471-34-1
Synonyms:
CaCO3
Calcium carbonate
Calcium carbonate (1:1)
Calciumcarbonat
Carbonate de calcium
 
Carbonato de calcio
Carbonic acid calcium salt (1:1)
E 170
Kalziumkarbonat
Kohlensaurer kalk
Precipitated calcium carbonate
4
Hydrogen peroxide487722-84-1784
Synonyms:
Adeka Super EL
Albone
Albone 35
Albone DS
Anti-Keim 50
Asepticper
Baquashock
CIX
Clarigel Gold
Crestal Whitestrips
Crystacide
Dentasept
Deslime LP
Hioxyl
Hipox
Hybrite
Hydrogen dioxide
Hydrogen peroxide
Inhibine
Lase Peroxide
Lensan A
 
Magic Bleaching
Metrokur
Mirasept
Nite White Excel 2
Odosat D
Opalescence Xtra
Oxigenal
Oxydol
Oxyfull
Oxysept
Oxysept I
Pegasyl
Perhydrol
Perone
Peroxaan
Peroxclean
Quasar Brite
Select Bleach
Superoxol
T-Stuff
Whiteness HP
Whitespeed
Xtra White
5
Ethanol197164-17-5702
Synonyms:
(C6-C9)Alkyl alcohol
02483_FLUKA
02851_FLUKA
02853_FLUKA
02854_FLUKA
02855_FLUKA
02856_FLUKA
02856_SIAL
02857_FLUKA
02857_SIAL
02858_FLUKA
02858_SIAL
02860_FLUKA
02865_FLUKA
02865_SIAL
02870_FLUKA
02870_SIAL
02875_FLUKA
02877_FLUKA
02878_FLUKA
02882_FLUKA
02882_SIAL
02883_FLUKA
02884_FLUKA
02890_FLUKA
02890_SIAL
02891_FLUKA
02891_SIAL
1-Hydroxyethane
100C.NPA
121182-78-3
187380_ALDRICH
187380_SIAL
24102_RIEDEL
24102_SIAL
24103_RIEDEL
24103_SIAL
24105_RIEDEL
24105_SIAL
24106_RIEDEL
24106_SIAL
24194_RIEDEL
24194_SIAL
245119_ALDRICH
245119_SIAL
270741_ALDRICH
270741_SIAL
277649_ALDRICH
277649_SIAL
2858_SIGMA
29221_FLUKA
32205_RIEDEL
32205_SIAL
32221_RIEDEL
32221_SIAL
32294_RIEDEL
32294_SIAL
34870_SIAL
34963_RIEDEL
39278_FLUKA
40210_ALDRICH
40210_RIEDEL
41322_FLUKA
458600_ALDRICH
458600_SIAL
459828_ALDRICH
459828_SIAL
459836_ALDRICH
459836_SIAL
459844_SIAL
48075_SUPELCO
493511_SIAL
493538_ALDRICH
493538_SIAL
493546_ALDRICH
493546_SIAL
64-17-5
676829_SIAL
68475-56-9
71076-86-3
71329-38-9
8000-16-6
8024-45-1
AC1L19TW
AC1Q31MM
AHD 2000
AI3-01706
ALCOHOL 5% IN D5-W
Absolute Alcohol
Absolute Ethanol
Absolute alcohol
Absolute ethanol
Absolute ethyl alcohol
Aethanol
Aethanol [German]
Aethylalkohol
Alcare Hand Degermer
Alcohol
Alcohol (USP)
Alcohol (ethyl)
Alcohol Anhydrous
Alcohol [USP]
Alcohol anhydrous
Alcohol dehydrated
Alcohol denatured
Alcohol etílico
Alcohol, Absolute
Alcohol, Dehydrated
Alcohol, Diluted
Alcohol, Grain
Alcohol, anhydrous
Alcohol, dehydrated
Alcohol, denatured
Alcohol, diluted
Alcohol, ethyl
Alcohols
Alcohols, C1-3
Alcohols, C30
Alcohols, C6-9
Alcool Ethylique
Alcool Etilico
Alcool ethylique
Alcool etilico
Alcool éthylique
Algrain
Alkohol
Alkohol [German]
Alkoholu Etylowego
Alkoholu etylowego
Aminoethanol
Anhydrol
Anhydrol PM 4085
Anhydrous alcohol
Anhydrous ethanol
Beta-Aminoethanol
Beta-Aminoethyl Alcohol
Beta-Ethanolamine
Beta-Hydroxyethylamine
C00469
C2H5OH
C2H6O
CCRIS 945
CDA 19
CDA 19-200
CHEBI:16236
CHEMBL545
CID702
Caswell No. 426
Caswell No. 430
Colamine
Cologne Spirit
Cologne spirit
Cologne spirits
 
D000431
D00068
DB00898
Dehydrated Ethanol
Dehydrated alcohol
Dehydrated ethanol
Denatured Alcohol
Denatured Alcohol Cd-10
Denatured Alcohol Cd-5
Denatured Alcohol Cd-5a
Denatured Alcohol Sd-1
Denatured Alcohol Sd-13a
Denatured Alcohol Sd-17
Denatured Alcohol Sd-23a
Denatured Alcohol Sd-28
Denatured Alcohol Sd-30
Denatured Alcohol Sd-39b
Denatured Alcohol Sd-39c
Denatured Alcohol Sd-3a
Denatured Alcohol Sd-40m
Denatured Ethanol
Denatured alcohol
Denatured ethanol
Desinfektol EL
Diluted Alcohol
Distilled spirits
E2385_SIGMA
E7023_ALDRICH
E7023_SIAL
E7148_ALDRICH
E7148_SIAL
E7517_SIGMA
EINECS 200-578-6
EINECS 270-649-4
EOH
EOX
ETA
Envision Conditioner Pdd 9020
Esumiru WK 88
EtOH
Etanolo
Etanolo [Italian]
Ethanol (9CI)
Ethanol 200 Proof
Ethanol 200 proof
Ethanol Absolute
Ethanol Absolute Bp
Ethanol Anhydrous
Ethanol Extra Pure
Ethanol Vapor
Ethanol [JAN]
Ethanol solution
Ethanol, Silent Spirit
Ethanol, undenatured
Ethanolum anhydricum
Ethicap
Ethyl Alcohol
Ethyl Alcohol & Water, 10%
Ethyl Alcohol & Water, 20%
Ethyl Alcohol & Water, 30%
Ethyl Alcohol & Water, 40%
Ethyl Alcohol & Water, 5%
Ethyl Alcohol & Water, 50%
Ethyl Alcohol & Water, 60%
Ethyl Alcohol & Water, 70%
Ethyl Alcohol & Water, 80%
Ethyl Alcohol & Water, 95%
Ethyl Alcohol & Water, 96%
Ethyl Alcohol Anhydrous
Ethyl Alcohol, Anhydrous
Ethyl Alcohol, Denatured
Ethyl Hydrate
Ethyl Hydroxide
Ethyl alc
Ethyl alcohol
Ethyl alcohol anhydrous
Ethyl alcohol in alcoholic beverages
Ethyl alcohol usp
Ethyl hydrate
Ethyl hydroxide
Ethylalcohol
Ethylalcohol [Dutch]
Ethylol
Ethylolamine
Ethyloxy Group
Etylowy alkohol
FEMA No. 2419
FEMA Number 2419
Fermentation alcohol
Glycinol
Grain alcohol
HSDB 531
HSDB 82
HYDROXYETHYL GROUP
Hinetoless
Hydroxyethane
I14-12648
IMS 99
Infinity Pure
Jaysol
Jaysol S
LS-1539
LTBB002977
Lux
Methylated Spirit Mineralised
Methylated spirit
Methylcarbinol
MolPort-001-785-844
Molasses alcohol
NCGC00091458-01
NCI-C03134
NSC 85228
NSC85228
Oxydimethylene Group
Potato alcohol
Punctilious ethyl alcohol
Pyro
QMHAIh@
Reagent Alcohol
Ru-Tuss Expectorant
SDA 3A
SDA 40-2
SDM No. 37
SY Fresh M
Sekundasprit
Silent spirit
Spirit
Spirits of wine
Spiritus vini
Spirt
Synasol
Tecsol
Tecsol C
Thanol
Thiofaco M-50
UNII-3K9958V90M
USAF EK-1597
Undenatured Ethanol
WLN: Q2
absolute alcohol
alcohol
alcohol etilico
bmse000297
etanol
ethanol
ethyl alcohol
grain alcohol
nchem.651-comp3c
nchembio.552-comp10
nchembio.94-comp20
spiritus vini
Äthanol
Äthylalkohol
éthanol

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effect of pH and Fluoride Concentration of Dentifrices on Caries ControlCompletedNCT01049503Phase 3
2Anticaries Potential and Fluorosis Risk From Different Fluoride ToothpastesCompletedNCT01589991Phase 1
3Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as AbrasivesCompletedNCT01571050Phase 1
4Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated WaterCompletedNCT01978041Phase 1
5Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis StainsCompletedNCT01733888
6Fluoride Intake From Toothbrushig With Children's or Regular ToothpastesCompletedNCT01568541
7Action of Infiltration Resin Icon in Fluorosis, Clinical Trial, Monitoring for 12 MonthNot yet recruitingNCT02925780

Search NIH Clinical Center for Dental Fluorosis


Cochrane evidence based reviews: fluorosis, dental

Genetic Tests for Dental Fluorosis

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Anatomical Context for Dental Fluorosis

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MalaCards organs/tissues related to Dental Fluorosis:

34
Bone, Thyroid, Testes, Brain

Animal Models for Dental Fluorosis or affiliated genes

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Publications for Dental Fluorosis

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Articles related to Dental Fluorosis:

(show top 50)    (show all 433)
idTitleAuthorsYear
1
Timing of fluoride intake and dental fluorosis on late-erupting permanent teeth. (26198477)
2015
2
Dental fluorosis: concentration of fluoride in drinking water and consumption of bottled beverages in school children. (25571686)
2014
3
Dental Fluorosis and Dental Caries Prevalence among 12 and 15-Year-Old School Children in Nalgonda District, Andhra Pradesh, India. (25364597)
2014
4
Enamel crystals of mice susceptible or resistant to dental fluorosis: an AFM study. (25025555)
2014
5
Reversal of dental fluorosis: A clinical study. (23633850)
2013
6
Dental fluorosis, dental caries, and quality of life factors among schoolchildren in a Colombian fluorotic area. (22482258)
2012
7
Coal-burning roasted corn and chili as the cause of dental fluorosis for children in southwestern China. (21074315)
2011
8
Prevalence and severity of dental fluorosis in the United States, 1999-2004. (21211168)
2010
9
Prevalence of dental fluorosis in children taking part in an oral health programme including fluoride tablet supplements from the age of 2 years. (20642466)
2010
10
Natural fluoride levels in the drinking water, water fluoridation and estimated risk of dental fluorosis in a tropical region of Brazil. (20480057)
2010
11
Considerations on optimal fluoride intake using dental fluorosis and dental caries outcomes--a longitudinal study. (19054310)
2009
12
Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis. (19425228)
2009
13
Clinical efficacy of 5% sodium hypochlorite for removal of stains caused by dental fluorosis. (19476089)
2009
14
Fluoride intake by children at risk for the development of dental fluorosis: comparison of regular dentifrices and flavoured dentifrices for children. (17823508)
2007
15
Prevalence of dental fluorosis in children from non-water-fluoridated Halmstad, Sweden: fluoride toothpaste use in infancy. (16095064)
2005
16
Relationship between dental fluorosis and quality of life: a population based study. (16292450)
2005
17
Dental fluorosis and nutritional status of 6- to 11-year-old children living in rural areas of ParaA-ba, Brazil. (9831782)
1999
18
Fluoride exposure and dental fluorosis in Newburgh and Kingston, New York: policy implications. (10385354)
1999
19
Re: Vegetarianism and dental fluorosis among children in a high fluoride area of northern Tanzania (1999;9: 3-11) (10841607)
1999
20
Dental fluorosis among persons exposed to high- and low-fluoride drinking water in western Norway. (10403085)
1999
21
A pilot study of esthetic perceptions of dental fluorosis vs. selected other dental conditions. (9740940)
1998
22
Changes in dental fluorosis and dental caries in Newburgh and Kingston, New York. (9842391)
1998
23
Dental fluorosis in Chilean children: evaluation of risk factors. (9792122)
1998
24
Dental fluorosis, altitude, and associated dietary factors (short communication). (1568240)
1992
25
Dental fluorosis and fluoride exposure in Western Australia. (2066481)
1991
26
An new concept for removal of dental fluorosis stains. (1940756)
1991
27
Differential diagnosis of dental fluorosis. (2179334)
1990
28
Dental fluorosis in children in the 1980s. A review of the literature. (3075187)
1988
29
Risk factors for dental fluorosis in a fluoridated community. (3198847)
1988
30
Effect of fluoride ingestion on dental fluorosis in sheep. (3592393)
1987
31
Dental fluorosis in bovine temporary teeth. (3994105)
1985
32
Dental caries, oral hygiene, periodontal disease and dental fluorosis among school children in northern Tanzania. Oral health surveys. (6582453)
1983
33
Dose-response relationship between water fluoride levels and the category of questionable dental fluorosis. (6573236)
1983
34
Skeletal development and dental fluorosis in 12--14-year-old Danish girls from a fluoride and a non-fluoride community. (6951260)
1982
35
Prevalence of dental fluorosis in relation to fluoride in drinking water in two villages of Varanasi (U.P.). (7183550)
1982
36
Water quality and dental fluorosis. (7262990)
1981
37
Influence of fluoride in surface enamel and degree of dental fluorosis on caries development in vitro. (6929731)
1980
38
Determination of optimal fluoride concentration in drinking water in an area in India with dental fluorosis. (6934064)
1980
39
Hypothetical protocol: epidemiological survey title: an epidemiologic study of dental caries and dental fluorosis. (6930401)
1980
40
Fluorides and dental fluorosis. (277779)
1978
41
Distribution of dental fluorosis in the primary dentition. (282115)
1978
42
An unusual incident of dental fluorosis: report of a case. (264940)
1977
43
Clinical and structural features and possible pathogenic mechanisms of dental fluorosis. (272716)
1977
44
Dental fluorosis associated with hereditary diabetes insipidus. (1060029)
1975
45
Oral health of Australian aborigines: endemic dental fluorosis. (4510019)
1972
46
Dental fluorosis in Grand Rapids during the seventeenth year of fluoridation. (13975635)
1962
47
A note on dental fluorosis at Tristan da Cunha. (13429646)
1957
48
Experience in preventing dental fluorosis by using low-fluoride bottled water. (13408424)
1957
49
Dental fluorosis and water fluoridation. (13234849)
1955
50
The teeth of the ox in clinical diagnosis. IV. Dental fluorosis. (13228865)
1955

Variations for Dental Fluorosis

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Expression for genes affiliated with Dental Fluorosis

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Search GEO for disease gene expression data for Dental Fluorosis.

Pathways for genes affiliated with Dental Fluorosis

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GO Terms for genes affiliated with Dental Fluorosis

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Cellular components related to Dental Fluorosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:00432049.3BGLAP, ESR1, ESR2
2proteinaceous extracellular matrixGO:00055788.3AMELX, AMELY, DSPP, MMP20
3extracellular regionGO:00055768.1BGLAP, COL1A2, DSPP, ESR2, MMP20

Biological processes related to Dental Fluorosis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1osteoblast developmentGO:000207610.3BGLAP, ESR1
2odontogenesisGO:004247610.2BGLAP, COL1A2
3regulation of neuron apoptotic processGO:004352310.2ESR1, ESR2
4Sertoli cell proliferationGO:006001110.2ESR1, ESR2
5collagen catabolic processGO:003057410.0COL1A2, MMP20
6negative regulation of smooth muscle cell proliferationGO:004866210.0ESR1, ESR2
7negative regulation of neuron deathGO:190121510.0ESR1, ESR2
8cellular response to estradiol stimulusGO:007139210.0ESR1, ESR2
9intracellular estrogen receptor signaling pathwayGO:00305209.9ESR1, ESR2
10response to testosteroneGO:00335749.9BGLAP, ESR2
11response to nutrient levelsGO:00316679.7BGLAP, ESR2
12Sertoli cell developmentGO:00600099.6ESR1, ESR2
13positive regulation of epidermal growth factor receptor signaling pathwayGO:00457429.6ESR1, ESR2
14skeletal system developmentGO:00015019.5BGLAP, COL1A2, DSPP
15response to estrogenGO:00436279.5BGLAP, ESR1, ESR2
16response to activityGO:00148239.4BGLAP, ESR2
17biomineral tissue developmentGO:00312148.7AMELX, AMELY, DSPP

Molecular functions related to Dental Fluorosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA bindingGO:003805210.2ESR1, ESR2
2estrogen receptor activityGO:003028410.2ESR1, ESR2
3estrogen response element bindingGO:003405610.1ESR1, ESR2
4RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:000487910.1ESR1, ESR2
5steroid hormone receptor activityGO:000370710.1ESR1, ESR2
6hydroxyapatite bindingGO:00468489.9AMELX, BGLAP
7core promoter sequence-specific DNA bindingGO:00010469.7ESR1, ESR2
8steroid bindingGO:00054969.6ESR1, ESR2
9extracellular matrix structural constituentGO:00052019.6COL1A2, DSPP
10structural constituent of tooth enamelGO:00303459.5AMELX, AMELY

Sources for Dental Fluorosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet