MCID: DNT001
MIFTS: 49

Dental Fluorosis malady

Gastrointestinal diseases, Oral diseases categories

Summaries for Dental Fluorosis

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Dental fluorosis, also called mottling of tooth enamel, is a developmental disturbance of dental enamel... more...

MalaCards: Dental Fluorosis, also known as intrinsic enamel discolouration of fluorosis, is related to dental caries and dentin dysplasia. An important gene associated with Dental Fluorosis is AMELY (amelogenin, Y-linked), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and Nuclear Receptor transcription pathway. The compounds isopropylparaben and 4-octylphenol have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and testes, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Dental Fluorosis

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

dental fluorosis 9 11
intrinsic enamel discolouration of fluorosis 9
dental fluorosis, acquired 63
mottling of enamel 9
mottled teeth 9


External Ids:

Disease Ontology9 DOID:13711
ICD9CM28 520.3
MeSH36 D009050
SNOMED-CT59 30265004
NCIt41 C85059
ICD1026 K00.3

Related Diseases for Dental Fluorosis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to dental fluorosis

Symptoms for Dental Fluorosis

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Drugs & Therapeutics for Dental Fluorosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Dental Fluorosis

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Genetic Tests for Dental Fluorosis

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Anatomical Context for Dental Fluorosis

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34MalaCards
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MalaCards organs/tissues related to Dental Fluorosis:

34
Bone, Thyroid, Testes

Animal Models for Dental Fluorosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Dental Fluorosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9ESR1, ESR2, AMELX, DMTF1

Publications for Dental Fluorosis

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53PubMed
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Articles related to Dental Fluorosis:

(show top 50)    (show all 377)
idTitleAuthorsYear
1
Minimally invasive treatment for esthetic management of severe dental fluorosis: a case report. (23210860)
2013
2
Reversal of dental fluorosis: A clinical study. (23633850)
2013
3
Osteo-dental fluorosis in relation to chemical constituents of drinking waters. (23741872)
2012
4
Dental fluorosis, dental caries, and quality of life factors among schoolchildren in a Colombian fluorotic area. (22482258)
2012
5
Coal-burning roasted corn and chili as the cause of dental fluorosis for children in southwestern China. (21074315)
2011
6
The relationships between low levels of urine fluoride on children's intelligence, dental fluorosis in endemic fluorosis areas in Hulunbuir, Inner Mongolia, China. (21237562)
2011
7
Prevalence and severity of dental fluorosis in the United States, 1999-2004. (21211168)
2010
8
Considerations on optimal fluoride intake using dental fluorosis and dental caries outcomes--a longitudinal study. (19054310)
2009
9
Exposure to high fluoride drinking water and risk of dental fluorosis in Estonia. (19440411)
2009
10
Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis. (19425228)
2009
11
Clinical efficacy of 5% sodium hypochlorite for removal of stains caused by dental fluorosis. (19476089)
2009
12
Risk factors associated with dental fluorosis in Central Plateau State, Nigeria. (18333878)
2008
13
Fluoride intake by children at risk for the development of dental fluorosis: comparison of regular dentifrices and flavoured dentifrices for children. (17823508)
2007
14
Dental fluorosis in cohorts born before, during, and after the national salt fluoridation program in a community in Mexico. (16829495)
2006
15
Prevalence of dental fluorosis in rural areas of Davangere, India. (15503846)
2004
16
Dental fluorosis and nutritional status of 6- to 11-year-old children living in rural areas of ParaA-ba, Brazil. (9831782)
1999
17
Fluoride exposure and dental fluorosis in Newburgh and Kingston, New York: policy implications. (10385354)
1999
18
Re: Vegetarianism and dental fluorosis among children in a high fluoride area of northern Tanzania (1999;9: 3-11) (10841607)
1999
19
Fluoride concentration in AgF and dental fluorosis. (9316315)
1997
20
Prevalence of dental caries and dental fluorosis in areas with optimal and above-optimal water fluoride concentrations: a 10-year follow-up survey. (7643332)
1995
21
Water fluoridation: current effectiveness and dental fluorosis. (8070242)
1994
22
Trends in prevalence of dental fluorosis in North America. (8070241)
1994
23
Dental fluorosis and fluoride exposure in Western Australia. (2066481)
1991
24
The severity of dental fluorosis in children exposed to water with a high fluoride content for various periods of time. (2045574)
1991
25
Differential diagnosis of dental fluorosis. (2179334)
1990
26
Re: A review of differential diagnosis of dental fluorosis and non-fluoride enamel defects. (2645022)
1989
27
Changes in dental fluorosis following an adjustment to the fluoride concentration of Hong Kong's water supplies. (2640426)
1989
28
Dental fluorosis in children in the 1980s. A review of the literature. (3075187)
1988
29
Dental caries and dental fluorosis. (3226636)
1988
30
Fluoride content of infant formulas: soy-based formulas as a potential factor in dental fluorosis. (3268804)
1988
31
Risk factors for dental fluorosis in a fluoridated community. (3198847)
1988
32
Effect of fluoride ingestion on dental fluorosis in sheep. (3592393)
1987
33
Fluoride content of water, dust, soils and cereals in the endemic dental fluorosis area of Khouribga (Morocco). (3463255)
1986
34
Posteruptive tooth age and severity of dental fluorosis in Kenya. (3492031)
1986
35
Dental fluorosis in bovine temporary teeth. (3994105)
1985
36
A new method for assessing the prevalence of dental fluorosis--the Tooth Surface Index of Fluorosis. (6611361)
1984
37
Chemical treatment of endemic dental fluorosis. (6955830)
1982
38
Skeletal development and dental fluorosis in 12--14-year-old Danish girls from a fluoride and a non-fluoride community. (6951260)
1982
39
Caries and dental fluorosis in high-fluoride districts under sub-tropical conditions. (6943212)
1980
40
Influence of fluoride in surface enamel and degree of dental fluorosis on caries development in vitro. (6929731)
1980
41
Bovine dental fluorosis: histologic and physical characteristics. (646194)
1978
42
An unusual incident of dental fluorosis: report of a case. (264940)
1977
43
Clinical and structural features and possible pathogenic mechanisms of dental fluorosis. (272716)
1977
44
Assessment of the fluoride content of water in wells selected randomly and after examining schoolchildren for dental fluorosis. (4546731)
1973
45
Occurrence of dental fluorosis in Australian aboriginal children resident in Carnarvon, Western Australia. (5270578)
1970
46
A note on dental fluorosis at Tristan da Cunha. (13429646)
1957
47
Dental fluorosis and water fluoridation. (13234849)
1955
48
Dental fluorosis. (20994695)
1946
49
Dental Fluorosis. (21032333)
1946
50
Some Epidemiological Aspects of Chronic Endemic Dental Fluorosis. (18014440)
1936

Variations for Dental Fluorosis

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Expression for genes affiliated with Dental Fluorosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dental Fluorosis

Search GEO for disease gene expression data for Dental Fluorosis.

Pathways for genes affiliated with Dental Fluorosis

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Sources:
51PathCards, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 54QIAGEN, 31KEGG, 13EMD Millipore
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Compounds for genes affiliated with Dental Fluorosis

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 3BitterDB, 25HMDB, 52PharmGKB
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Compounds related to Dental Fluorosis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1isopropylparaben4610.1ESR2, ESR1
24-octylphenol4610.1ESR1, ESR2
3butylparaben4610.1ESR1, ESR2
4methylparaben4610.1ESR1, ESR2
5r,r-thc3010.1ESR1, ESR2
6isobutylparaben4610.1ESR2, ESR1
7lasofoxifene4610.1ESR1, ESR2
817alpha estradiol4610.1ESR1, ESR2
9ly 1170184610.1ESR1, ESR2
102,4,6-trichloro-4-biphenylol4610.1ESR1, ESR2
11teriparatide46 1211.1BGLAP, ESR1
12zeranol4610.1ESR2, ESR1
134-hydroxy?aetamoxifen3010.1ESR2, ESR1
144-tert-octylphenol4610.1ESR2, ESR1
15calcium carbonate4610.1BGLAP, DSPP
16ibandronate46 1211.1BGLAP, ESR1
17phtpp62 3011.1ESR2, ESR1
18dpn6210.1ESR2, ESR1
19ppt62 3011.1ESR2, ESR1
20ici 182,7806210.1ESR2, ESR1
21(z)-4-hydroxytamoxifen6210.1ESR2, ESR1
2217beta-estradiol3010.1ESR2, ESR1
23coumestrol 3 4611.1ESR2, ESR1
24tartrate4610.0BGLAP, DSPP
25equol4610.0ESR2, ESR1
26dichlorodiphenyltrichloroethane4610.0ESR1, ESR2
27zearalenone4610.0ESR1, ESR2
282-hydroxyestradiol46 2511.0ESR1, ESR2
29nonylphenol4610.0ESR2, ESR1
30trilostane46 1211.0ESR2, ESR1
31sodium fluoride4610.0DSPP, BGLAP
32estradiol benzoate4610.0ESR2, ESR1
33nandrolone46 2510.9ESR2, ESR1
34fluoride469.9MMP20, DSPP, BGLAP
35alendronate46 52 1211.9BGLAP, DSPP, ESR1
36anastrozole46 52 1211.9BGLAP, ESR2, ESR1
37exemestane46 52 62 1212.9BGLAP, ESR2, ESR1
385alpha-androstane-3alpha,17beta-diol469.8ESR2, ESR1
39xbai469.8ESR2, ESR1, COL1A2
40raloxifene46 52 30 1212.8BGLAP, ESR2, ESR1
41risedronate46 52 30 62 1213.8ESR1, BGLAP
42polyglycolic acid469.8BGLAP, DSPP
43leuprolide acetate469.8ESR2, ESR1
44estramustine46 1210.7ESR2, ESR1
45estrone46 30 25 1212.7ESR1, ESR2, BGLAP
46dihydrotestosterone46 30 25 1212.6ESR1, ESR2, BGLAP
47paraffin469.4ESR1, ESR2, DSPP, BGLAP
48isoflavone469.4ESR1, ESR2
49vitamin d469.2COL1A2, ESR1, ESR2, DSPP, BGLAP
50estrogen469.0COL1A2, ESR1, ESR2, DSPP, BGLAP

GO Terms for genes affiliated with Dental Fluorosis

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17Gene Ontology
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Cellular components related to Dental Fluorosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.9COL1A2, MMP20, ESR2, DSPP, BGLAP
2proteinaceous extracellular matrixGO:0055787.6MMP20, AMELX, AMELY, AMTN, DSPP, MMP25

Biological processes related to Dental Fluorosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:0600659.8ESR1, ESR2
2vagina developmentGO:0600689.8ESR1, ESR2
3intracellular estrogen receptor signaling pathwayGO:0305209.6ESR1, ESR2
4odontogenesisGO:0424769.6COL1A2, BGLAP
5skeletal system developmentGO:0015019.6BGLAP, DSPP, COL1A2
6extracellular matrix organizationGO:0301989.5COL1A2, MMP20, DSPP
7biomineral tissue developmentGO:0312149.3DSPP, AMTN, AMELY, AMELX

Molecular functions related to Dental Fluorosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1structural constituent of tooth enamelGO:03034510.1AMELX, AMELY
2hydroxyapatite bindingGO:04684810.1AMELX, BGLAP
3estrogen response element bindingGO:0340569.9ESR1, ESR2
4extracellular matrix structural constituentGO:0052019.9COL1A2, DSPP
5estrogen receptor activityGO:0302849.8ESR2, ESR1
6core promoter sequence-specific DNA bindingGO:0010469.8ESR1, ESR2
7steroid bindingGO:0054969.7ESR2, ESR1
8steroid hormone receptor activityGO:0037079.4ESR1, ESR2
9calcium ion bindingGO:0055098.6MMP20, MMP25, DSPP, BGLAP

Products for genes affiliated with Dental Fluorosis

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  • Antibodies
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Sources for Dental Fluorosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet