MCID: DNT001
MIFTS: 35

Dental Fluorosis malady

Gastrointestinal diseases, Oral diseases categories

Aliases & Classifications for Dental Fluorosis

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Aliases & Descriptions for Dental Fluorosis:

Name: Dental Fluorosis 10 12
Mottling of Enamel 10 65
Intrinsic Enamel Discolouration of Fluorosis 10
 
Dental Fluorosis, Acquired 65
Fluorosis, Dental 36
Mottled Teeth 10


Classifications:



External Ids:

Disease Ontology10 DOID:13711
MeSH36 D009050
NCIt42 C85059
SNOMED-CT59 30265004
ICD9CM29 520.3
ICD1027 K00.3

Summaries for Dental Fluorosis

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Wikipedia:68 Dental fluorosis, also called mottling of tooth enamel, is a developmental disturbance of dental enamel... more...

MalaCards based summary: Dental Fluorosis, also known as mottling of enamel, is related to dental caries and diabetes insipidus. An important gene associated with Dental Fluorosis is COL1A2 (Collagen, Type I, Alpha 2), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. Affiliated tissues include bone, thyroid and testes.

Related Diseases for Dental Fluorosis

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Diseases related to Dental Fluorosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1dental caries11.0
2diabetes insipidus10.3
3periodontitis10.3
4thyroiditis10.3
5autosomal dominant microcephaly10.2COL1A2, DSPP
6caffey disease10.2BGLAP, COL1A2
7osteogenesis imperfecta, type iii10.2BGLAP, COL1A2
8osteogenesis imperfecta, type iv10.2COL1A2, DSPP
9amelogenesis imperfecta10.2
10burns10.2
11dentin dysplasia10.2
12gingivitis10.2
13periodontal disease10.2
14taurodontism10.2
15uterine cervix leukoplakia10.2DSPP, ESR1
16aromatase excess syndrome10.2BGLAP, ESR1
17depressed scar10.2COL1A2, DSPP
18progesterone resistance10.2ESR1, ESR2
19germ cell and embryonal cancer10.2ESR1, ESR2
20endometriosis in scar of skin10.1ESR1, ESR2
21breast granular cell tumor10.1ESR1, ESR2
22spinal meninges cancer10.1ESR1, ESR2
23biotin deficiency10.1COL1A2, ESR1
24vascular cancer10.1ESR1, ESR2
25lung leiomyosarcoma10.1ESR1, ESR2
26distal monosomy 9p10.1ESR1, ESR2
27her2-receptor positive breast cancer10.1ESR1, ESR2
28penile neoplasm10.1AMBN, DSPP
29polyvesicular vitelline pattern ovarian yolk sac tumor10.1ESR1, ESR2
30bone structure disease10.1BGLAP, ESR1
31progesterone-receptor negative breast cancer10.1ESR1, ESR2
32dental pulp disease10.1DSPP, MMP20
33anterior cruciate ligament tears10.1BGLAP, COL1A2, ESR1
34sapho syndrome10.1BGLAP, COL1A2, DSPP
35uterine ligament adenocarcinoma10.1ESR1, ESR2
36fibular collateral ligament bursitis10.1ESR1, ESR2
37endometrial stromal tumor10.0ESR1, ESR2
38asphyxiating thoracic dystrophy10.0COL1A2, DSPP, MMP20
39pediatric intraocular retinoblastoma10.0BGLAP, DSPP
40dieulafoy lesion10.0ESR1, ESR2
41gestational choriocarcinoma10.0ESR1, ESR2
42solitary necrotic tumor of the liver9.9AMBN, DSPP, MMP20
43telangiectasis9.9AMBN, DSPP, MMP20
44movement disease9.9AMBN, DSPP, MMP20
45osteoporosis9.9BGLAP, COL1A2, ESR1, ESR2
46gastrointestinal tuberculosis9.9AMBN, DSPP, MMP20
47anal fistula9.9AMBN, DSPP, MMP20
48breast duct papilloma9.9ESR1, ESR2
49anodontia8.8AMBN, BGLAP, C12orf10, COL1A2, CPQ, DSPP

Graphical network of the top 20 diseases related to Dental Fluorosis:



Diseases related to dental fluorosis

Symptoms for Dental Fluorosis

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Drugs & Therapeutics for Dental Fluorosis

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Drugs for Dental Fluorosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1FluoridesPhase 3, Phase 1327
2
Calcium carbonateapprovedPhase 1185
Synonyms:
7 Select Antacid
Alka-seltzer Fruit Chews
Alka-seltzer Heartburn Reliefchews
Alka-seltzer Heartburn Reliefchews Cool Mint
Alka-seltzer Heartburn Reliefchews Strawberry
Antacid
Antacid Extra Strength Assorted Berries
Antacid Ultra Strength
Antacid Ultra Strength Assorted Berries
Antacid extra strength
Antacid maximum strength ultra
Being Well Antacid
CaCO3
Calcid ANTACID CALCIUM SUPPLEMENT REGULAR STRENGTH
Calcium Antacid
Calcium Antacid extra strength
Calcium Carbonate
Calcium Carbonate (Antacid)
Calcium Carbonate Chewable Antacid
Calcium Carbonate Extra Strength Antacid
Calcium carbonate
Calcium carbonate (1:1)
Calciumcarbonat
Carbonate de calcium
Carbonato de calcio
Carbonic acid calcium salt (1:1)
Care One Calcium Antacid
Childrens Chewable Antacid
Childrens Pepto
Childrens Stomach Relief
Chooz
D-cal
D-cal Kids
Dg Health Antacid Calcium Supplement
Dg Health Antacid Calcium Supplement regular strength
Dg Health Calcium Antacid
Dg Health Calcium Antacid extra strength
Equaline Antacid
Equaline Antacid regular strength
Equate Antacid
Equate Antacid regular strength
Exchange Select Calcium Antacid
Extra Strength
Extra Strength antacid calcium supplement
First Aid Shot Therapy Upset Stomach Relief
Formu Care Calcium Antacid
Good Sense Antacid
Green Guard Stomach Relief
Health Mart Calcium Antacid
Health Mart Calcium Antacid Assorted Fruit
 
Healthmart Calcium Antacid
Healthy Accents Antacid
Healthy Accents Antacid extra strength
Healthy Mama TAME THE FLAME
Heartburn Relief To Go
His Ulc Mint Blue
Kalziumkarbonat
Kirkland Signature Antacid
Kohlensaurer kalk
Leader Antacid
Leader Antacid Regular Strength
Maximum Strength
Medi First Antacid
Medi First Plus Antacid
Medi-first Antacid
Medi-first Plus Antacid
Medique Alcalak
Medique Ban-acid Maximum Strength 750
Meijer Softchews
Miralac
Miralac Antacid
Moore Medical Antacid
Nutralox
Physicianscare Antacid
Plus Pharma Calcium Antacid
Precipitated calcium carbonate
Regular Strength
Regular Strength Antacid Calcium Supplement
Rexall Antacid
Rx Act Antacid extra strength
Select Brand Antacid Assorted Berries
Sunmark Assorted Berries
Sunmark Calcium Antacid
Sunmark Calcium Antacid REGULAR STRENGTH
Sunmark Calcium Antacid extra strength
Sunmark Calcium Antacid regular strength
Sunmark Smooth Antacid
Titralac
Topcare Antacid Calcium
Topcare Antacid Calcium Extra Strength
Topcare Antacid Calcium Regular Strength
Topcare Antacid Calcium Ultra Strength
Trial Antacid
Tums
Tums Chewy Delights
Tums EX
Tums Smoothies
Tums ULTRA
Tums freshers
Ultrastrength
Welby Health Antacid
e 170
3Calcium, DietaryPhase 13529
4sodium fluoridePhase 1145
5ListerinePhase 1145
6
Hydrogen peroxide427722-84-1784
Synonyms:
Adeka Super EL
Albone
Albone 35
Albone DS
Anti-Keim 50
Asepticper
Baquashock
CIX
Clarigel Gold
Crestal Whitestrips
Crystacide
Dentasept
Deslime LP
Hioxyl
Hipox
Hybrite
Hydrogen dioxide
Hydrogen peroxide
Inhibine
Lase Peroxide
Lensan A
 
Magic Bleaching
Metrokur
Mirasept
Nite White Excel 2
Odosat D
Opalescence Xtra
Oxigenal
Oxydol
Oxyfull
Oxysept
Oxysept I
Pegasyl
Perhydrol
Perone
Peroxaan
Peroxclean
Quasar Brite
Select Bleach
Superoxol
T-Stuff
Whiteness HP
Whitespeed
Xtra White
7

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effect of pH and Fluoride Concentration of Dentifrices on Caries ControlCompletedNCT01049503Phase 3
2Anticaries Potential and Fluorosis Risk From Different Fluoride ToothpastesCompletedNCT01589991Phase 1
3Systemic Fluoride Bioavailability From Toothpastes Containing Calcium Carbonate or Silica as AbrasivesCompletedNCT01571050Phase 1
4Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated WaterCompletedNCT01978041Phase 1
5Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis StainsCompletedNCT01733888
6Fluoride Intake From Toothbrushig With Children's or Regular ToothpastesCompletedNCT01568541

Search NIH Clinical Center for Dental Fluorosis


Cochrane evidence based reviews: Fluorosis, Dental

Genetic Tests for Dental Fluorosis

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Anatomical Context for Dental Fluorosis

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MalaCards organs/tissues related to Dental Fluorosis:

33
Bone, Thyroid, Testes

Animal Models for Dental Fluorosis or affiliated genes

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Publications for Dental Fluorosis

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Articles related to Dental Fluorosis:

(show top 50)    (show all 413)
idTitleAuthorsYear
1
Timing of fluoride intake and dental fluorosis on late-erupting permanent teeth. (26198477)
2015
2
Association between urine fluoride and dental fluorosis as a toxicity factor in a rural community in the state of San Luis Potosi. (25789336)
2015
3
Retention of fissure sealants in young permanent molars affected by dental fluorosis: a 12-month clinical study. (24737141)
2014
4
Dental fluorosis: concentration of fluoride in drinking water and consumption of bottled beverages in school children. (25571686)
2014
5
Minimally invasive treatment for esthetic management of severe dental fluorosis: a case report. (23210860)
2013
6
Reversal of dental fluorosis: A clinical study. (23633850)
2013
7
Prevalence and self perception of Dental Fluorosis among 15 year old school children in Prakasham district of south India. (24453447)
2013
8
Osteo-dental fluorosis in relation to chemical constituents of drinking waters. (23741872)
2012
9
Coal-burning roasted corn and chili as the cause of dental fluorosis for children in southwestern China. (21074315)
2011
10
The relationships between low levels of urine fluoride on children's intelligence, dental fluorosis in endemic fluorosis areas in Hulunbuir, Inner Mongolia, China. (21237562)
2011
11
Prevalence and severity of dental fluorosis in the United States, 1999-2004. (21211168)
2010
12
Considerations on optimal fluoride intake using dental fluorosis and dental caries outcomes--a longitudinal study. (19054310)
2009
13
Exposure to high fluoride drinking water and risk of dental fluorosis in Estonia. (19440411)
2009
14
Relationship between fluoride intake in Serbian children living in two areas with different natural levels of fluorides and occurrence of dental fluorosis. (19425228)
2009
15
Risk factors associated with dental fluorosis in Central Plateau State, Nigeria. (18333878)
2008
16
Fluoride intake by children at risk for the development of dental fluorosis: comparison of regular dentifrices and flavoured dentifrices for children. (17823508)
2007
17
Dental fluorosis in cohorts born before, during, and after the national salt fluoridation program in a community in Mexico. (16829495)
2006
18
Prevalence of dental fluorosis in rural areas of Davangere, India. (15503846)
2004
19
Dental fluorosis and nutritional status of 6- to 11-year-old children living in rural areas of ParaA-ba, Brazil. (9831782)
1999
20
Fluoride exposure and dental fluorosis in Newburgh and Kingston, New York: policy implications. (10385354)
1999
21
Re: Vegetarianism and dental fluorosis among children in a high fluoride area of northern Tanzania (1999;9: 3-11) (10841607)
1999
22
Fluoride concentration in AgF and dental fluorosis. (9316315)
1997
23
Prevalence of dental caries and dental fluorosis in areas with optimal and above-optimal water fluoride concentrations: a 10-year follow-up survey. (7643332)
1995
24
Water fluoridation: current effectiveness and dental fluorosis. (8070242)
1994
25
Trends in prevalence of dental fluorosis in North America. (8070241)
1994
26
Dental fluorosis and fluoride exposure in Western Australia. (2066481)
1991
27
The severity of dental fluorosis in children exposed to water with a high fluoride content for various periods of time. (2045574)
1991
28
Differential diagnosis of dental fluorosis. (2179334)
1990
29
Re: A review of differential diagnosis of dental fluorosis and non-fluoride enamel defects. (2645022)
1989
30
Changes in dental fluorosis following an adjustment to the fluoride concentration of Hong Kong's water supplies. (2640426)
1989
31
Dental fluorosis in children in the 1980s. A review of the literature. (3075187)
1988
32
Dental caries and dental fluorosis. (3226636)
1988
33
Risk factors for dental fluorosis in a fluoridated community. (3198847)
1988
34
Effect of fluoride ingestion on dental fluorosis in sheep. (3592393)
1987
35
Fluoride content of water, dust, soils and cereals in the endemic dental fluorosis area of Khouribga (Morocco). (3463255)
1986
36
Posteruptive tooth age and severity of dental fluorosis in Kenya. (3492031)
1986
37
Dental fluorosis in bovine temporary teeth. (3994105)
1985
38
A new method for assessing the prevalence of dental fluorosis--the Tooth Surface Index of Fluorosis. (6611361)
1984
39
Chemical treatment of endemic dental fluorosis. (6955830)
1982
40
Caries and dental fluorosis in high-fluoride districts under sub-tropical conditions. (6943212)
1980
41
Influence of fluoride in surface enamel and degree of dental fluorosis on caries development in vitro. (6929731)
1980
42
Bovine dental fluorosis: histologic and physical characteristics. (646194)
1978
43
An unusual incident of dental fluorosis: report of a case. (264940)
1977
44
Clinical and structural features and possible pathogenic mechanisms of dental fluorosis. (272716)
1977
45
Assessment of the fluoride content of water in wells selected randomly and after examining schoolchildren for dental fluorosis. (4546731)
1973
46
Occurrence of dental fluorosis in Australian aboriginal children resident in Carnarvon, Western Australia. (5270578)
1970
47
A note on dental fluorosis at Tristan da Cunha. (13429646)
1957
48
Dental fluorosis and water fluoridation. (13234849)
1955
49
Dental fluorosis. (20994695)
1946
50
Some Epidemiological Aspects of Chronic Endemic Dental Fluorosis. (18014440)
1936

Variations for Dental Fluorosis

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Expression for genes affiliated with Dental Fluorosis

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Search GEO for disease gene expression data for Dental Fluorosis.

Pathways for genes affiliated with Dental Fluorosis

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GO Terms for genes affiliated with Dental Fluorosis

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Cellular components related to Dental Fluorosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055788.9AMBN, DSPP, MMP20
2extracellular regionGO:00055768.5BGLAP, COL1A2, DSPP, ESR2, MMP20

Biological processes related to Dental Fluorosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1odontogenesisGO:004247610.3BGLAP, COL1A2
2steroid hormone mediated signaling pathwayGO:004340110.1ESR1, ESR2
3biomineral tissue developmentGO:003121410.0AMBN, DSPP
4intracellular estrogen receptor signaling pathwayGO:00305209.9ESR1, ESR2
5skeletal system developmentGO:00015019.4BGLAP, COL1A2, DSPP
6extracellular matrix organizationGO:00301989.3COL1A2, DSPP, MMP20

Molecular functions related to Dental Fluorosis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1estrogen receptor activityGO:003028410.2ESR1, ESR2
2estrogen response element bindingGO:003405610.1ESR1, ESR2
3steroid hormone receptor activityGO:00037079.9ESR1, ESR2
4RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:00048799.9ESR1, ESR2
5extracellular matrix structural constituentGO:00052019.8COL1A2, DSPP
6core promoter sequence-specific DNA bindingGO:00010469.8ESR1, ESR2
7steroid bindingGO:00054969.7ESR1, ESR2

Sources for Dental Fluorosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet