Aliases & Classifications for Dental Pulp Disease

MalaCards integrated aliases for Dental Pulp Disease:

Name: Dental Pulp Disease 12 14
Dental Pulp Diseases 41 69
Disorder of Pulp of Tooth 12
Dental Pulp Disorder 12
Pulp Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5330
MeSH 41 D003788
NCIt 46 C34530
SNOMED-CT 64 57203004
UMLS 69 C0011405

Summaries for Dental Pulp Disease

MalaCards based summary : Dental Pulp Disease, also known as dental pulp diseases, is related to paroxysmal extreme pain disorder and diverticulitis of colon, and has symptoms including toothache An important gene associated with Dental Pulp Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Bacterial infections in CF airways and Immune response IFN alpha/beta signaling pathway. The drugs Epinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include testes and bone.

Related Diseases for Dental Pulp Disease

Diseases related to Dental Pulp Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 paroxysmal extreme pain disorder 10.5 SCN11A TRPV1
2 diverticulitis of colon 10.4 NPS TRPV1
3 trigeminal neuralgia 10.3 SCN11A TRPV1
4 periapical periodontitis 10.3 DSPP IL1B SASS6
5 recurrent corneal erosion 10.3 CXCL8 IL1B
6 bagassosis 10.3 CXCL8 IL1B
7 aspiration pneumonia 10.3 TAC1 TRPV1
8 peptic esophagitis 10.3 CXCL8 IL1B
9 funisitis 10.3 CXCL8 IL1B
10 retinitis pigmentosa 68 10.3 NPS TAC1
11 dental fluorosis 10.3 AMELX DSPP
12 epicondylitis 10.3 NPS TAC1
13 polyposis, gastric 10.3 IL1B TNF
14 opisthorchiasis 10.3 CXCL8 IL1B
15 systemic onset juvenile idiopathic arthritis 10.2 IL1B TNF
16 staphylococcal toxic shock syndrome 10.2 IL1B TNF
17 tooth resorption 10.2 AMELX DSPP
18 kashin-beck disease 10.2 IL1B TNF
19 vulvar vestibulitis syndrome 10.2 IL1B TNF
20 somatoform disorder 10.2 IL1B TAC1 TRPV1
21 burns 10.2 IL1B TNF
22 trigeminal nerve disease 10.2 SCN11A TAC1 TRPV1
23 laryngitis 10.2 IL1B TNF
24 aplasia of lacrimal and salivary glands 10.2 DSPP TAC1
25 cerebral artery occlusion 10.2 IL1B TNF
26 retinitis pigmentosa 60 10.2 IL1B TNF
27 acute vascular insufficiency of intestine 10.2 IL1B TNF
28 vaginal disease 10.1 CXCL8 DSPP IL1B
29 stomach disease 10.1 CXCL8 IL1B TRPV1
30 endometrial disease 10.1 CXCL8 DSPP IL1B
31 actinic prurigo 10.1 IL1B TNF
32 poems syndrome 10.1 IL1B TNF
33 gastroesophageal reflux 10.1 CXCL8 IL1B TRPV1
34 esophagitis 10.1 CXCL8 IL1B TRPV1
35 irritant dermatitis 10.1 IL1B TNF
36 vaginitis 10.1 CXCL8 IL1B
37 central nervous system vasculitis 10.1 IL1B TNF
38 osteosclerotic myeloma 10.1 IL1B TNF
39 stachybotrys chartarum 10.1 IL1B TNF
40 lacrimal apparatus disease 10.1 IL1B TNF TRPV1
41 tungiasis 10.1 CXCL8 TNF
42 streptococcal toxic-shock syndrome 10.1 CXCL8 TNF
43 hypersensitivity reaction disease 10.1 IL1B TNF TRPV1
44 interstitial cystitis 10.0 CXCL8 TAC1 TRPV1
45 glucose metabolism disease 10.0 IL1B TNF TRPV1
46 immune system disease 10.0 IL1B TNF TRPV1
47 arteries, anomalies of 10.0 IL1B TNF TRPV1
48 acquired metabolic disease 10.0 IL1B TNF TRPV1
49 trichuriasis 10.0 CXCL8 TNF
50 nervous system disease 10.0 IL1B TNF TRPV1

Graphical network of the top 20 diseases related to Dental Pulp Disease:



Diseases related to Dental Pulp Disease

Symptoms & Phenotypes for Dental Pulp Disease

UMLS symptoms related to Dental Pulp Disease:


toothache

Drugs & Therapeutics for Dental Pulp Disease

Drugs for Dental Pulp Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 142)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
2
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
3 Racepinephrine Approved Phase 4,Phase 3,Phase 2 329-65-7
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
6
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
7
Tramadol Approved, Investigational Phase 4,Phase 1,Phase 2 27203-92-5 33741
8
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
9
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
10
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
11
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
12
Ephedrine Approved Phase 4 299-42-3 9294
13
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
14
Phenylephrine Approved Phase 4 59-42-7 6041
15
Pseudoephedrine Approved Phase 4 90-82-4 7028
16
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
17
Bismuth Phase 4,Phase 2,Phase 3 7440-69-9 105143 16682734
18 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
19 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
20 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3
21 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1
22 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
23 Antitubercular Agents Phase 4,Phase 1,Early Phase 1
24 Anesthetics Phase 4,Phase 2,Phase 3
25 Anesthetics, Local Phase 4,Phase 3,Phase 2
26 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2
27 Carticaine Phase 4,Phase 3,Phase 2
28 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
29 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2
30 Epinephryl borate Phase 4,Phase 3,Phase 2
31 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
32 Sodium Channel Blockers Phase 4,Phase 3,Phase 2
33 Antiemetics Phase 4,Phase 3
34 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
35 Antineoplastic Agents, Hormonal Phase 4,Phase 3
36 Autonomic Agents Phase 4,Phase 3,Phase 2
37 Gastrointestinal Agents Phase 4,Phase 3
38 glucocorticoids Phase 4,Phase 3
39 Hormone Antagonists Phase 4,Phase 3
40 Hormones Phase 4,Phase 3
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
42 Methylprednisolone acetate Phase 4,Phase 3
43 Methylprednisolone Hemisuccinate Phase 4,Phase 3
44 Neuroprotective Agents Phase 4,Phase 3
45 Prednisolone acetate Phase 4,Phase 3
46 Prednisolone hemisuccinate Phase 4,Phase 3
47 Prednisolone phosphate Phase 4,Phase 3
48 Protective Agents Phase 4,Phase 3
49 Adrenergic Agents Phase 4,Phase 3,Phase 2
50 Adrenergic Agonists Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 139)

# Name Status NCT ID Phase Drugs
1 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Unknown status NCT02702505 Phase 4
2 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
3 Postoperative Pain in Single-visit and Multiple-visit Retreatment Cases Completed NCT03042377 Phase 4 Multiple-Visit-"Calcium Hydroxide";Multiple-Visit-"Corticosteroid Paste";Multiple-Visit-"Antibiotic Paste"
4 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars Completed NCT01496846 Phase 4 IANB Articaine;SUP Articaine;SUP Lidocaine
5 Oral Glucocorticoids Effect on Post Endodontic Pain Completed NCT02819648 Phase 4 Prednisolone
6 Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis Completed NCT02110966 Phase 4 Mepivacaine;Mepivacaine plus Tramadol
7 Dexketoprofen Trometamol in Postoperative Endodontic Pain Completed NCT02086097 Phase 4 Dexketoprofen trometamol;Ibuprofen;PLACEBO
8 Anesthetic Efficacy in Irreversible Pulpitis Completed NCT02054767 Phase 4 Intervention: inferior alveolar nerve block injection
9 Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits Completed NCT01912755 Phase 4 4% articaine with 1:100,000 epinephrine;2% lidocaine with 1:100,000 epinephrine
10 Prefabricated Endodontic Posts: Glass Fiber Versus Titanium - A Randomized Controlled Pilot- Trial Completed NCT01520766 Phase 4
11 Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma Completed NCT01817413 Phase 4
12 Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial Active, not recruiting NCT02201641 Phase 4
13 : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic Not yet recruiting NCT03368391 Phase 4 tetracaine HCl and oxymetazoline HCL;2% Lidocaine with 1:100,000 epinephrine;3% Mepivacaine with 1:100,000 epinephrine;saline intranasal;saline infiltration
14 Pretreatment Aceclofenac Effect on Pain and Analgesic Intake After Endodontic Treatment Completed NCT03335007 Phase 2, Phase 3 Aceclofenac
15 Pre-operative Aceclofenac on the Anesthetic Efficacy of IANB in Symptomatic Irreversible Pulpitis Completed NCT03146481 Phase 2, Phase 3 Aceclofenac
16 Effect of Inferior Alveolar and Gow-Gates Nerve Block Techniques for Symptomatic Mandibular Molars Completed NCT03117491 Phase 3
17 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis Completed NCT02807298 Phase 3 4%articaine;2% Lignocaine;Epinephrine
18 Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth Completed NCT02492841 Phase 2, Phase 3 Mineral trioxide aggregate;Calcium hydroxide;Biodentine
19 Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis Completed NCT02226913 Phase 3 2% lidocaine with 1:80,000 epinephrine;sodium bicarbonate;placebo
20 Human Pulpal Response After Pulp Capping With Four Different Agents Completed NCT01468480 Phase 2, Phase 3 Pro Root MTA;Pro Root MTA- single visit;MultiCal;Dycal
21 Partial Pulpotomy on Caries Free Human Teeth Completed NCT01420718 Phase 2, Phase 3 MTA;iRoot BP
22 Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth Completed NCT00472173 Phase 3 Mineral Trioxide Aggregate;Calcium hydroxide
23 Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy Recruiting NCT03376984 Phase 2, Phase 3
24 Effect of Preoperative Diclofenac Potassium on Postoperative Endodontic Pain Recruiting NCT03341260 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab.;Placebo
25 Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success Recruiting NCT03174860 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab;Placebo
26 Clinical Comparison of Endodontically Treated Teeth Restored With Fiber Posts or Cast Metal Posts Recruiting NCT01461239 Phase 3
27 Efficacy of Oral Prednisolone on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis Recruiting NCT02629042 Phase 3 prednisolone
28 Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy Recruiting NCT03084601 Phase 2, Phase 3 Calcium Hydroxide, Iodoform, paste;3-mixtatin
29 Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis Active, not recruiting NCT03163420 Phase 2, Phase 3 Diclofenac potassium
30 Regenerative Endodontic Procedure of Immature Permanent Teeth With L-PRF: a Pilot Controlled, Clinical Trial Active, not recruiting NCT02437708 Phase 3
31 A Clinical Study: the Antibacterial Effect of Insoluble Antibacterial Nanoparticles (IABN) Incorporated in Dental Materials for Root Canal Treatment Unknown status NCT01167985 Phase 2
32 Effect Of Different Lining Materials in Stepwise Excavation Unknown status NCT01730287 Phase 2 Control;Calcium Hydroxide;Mineral Trioxide Aggregate(MTA);CEM cement
33 Efficacy of Chlorexidine as Intracanal Medicament in Primary Teeth Unknown status NCT00624572 Phase 2 chlorexidine
34 Photodynamic Therapy in Endodontic Treatment Completed NCT02824601 Phase 2 Calcium hydroxide
35 Endodontic Treatment of Primary Teeth Using Mineral Trioxide Aggregate Paste Completed NCT02887456 Phase 2 Endodontic treatment using Vitapex;Endodontic treatment using MTA paste
36 Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain Completed NCT02614118 Phase 2 Ketorolac tromethamine;Acetaminophen;Placebo
37 Effect of Premedication on Success of Inferior Alveolar Nerve Block Injection Completed NCT02601911 Phase 2 Ketorolac Tromethamine;Acetaminophen
38 Effect of Fentanyl on the Rate of Anesthesia Completed NCT01794533 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + fentanyl
39 Effect of Sufentanil on the Rate of Anesthesia Completed NCT01572116 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + sufentanil
40 The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment Completed NCT01178203 Phase 1, Phase 2 Placebo;Tramadol;Novafen;Naproxen
41 MTA/FS Pulpotomy for Vital Primary Incisors: A Randomized Controlled Trial Completed NCT02019563 Phase 2
42 Chlorhexidine Intracanal Medicament in Periodontal Healing in Concomitant Endo Perio Lesion With Communication Completed NCT02627326 Phase 2
43 Efficacy of Different Drugs to Control Post Root Canal Treatment Pain Completed NCT02417337 Phase 2 Paracetamol;Ibuprofen;Mefenamic acid;Diclofenac
44 A Clinical Study to Compare Two Revascularization Protocols to Treat Non-vital Teeth With Incomplete Root Formation Recruiting NCT01827098 Phase 2
45 Effect of High-dose Naloxone Following Third Molar Extraction Recruiting NCT02976337 Phase 2 Naloxone;Normal Saline
46 Application of Photodynamic Therapy and Diode Laser for Endodontic Therapy of Young Permanent Teeth Active, not recruiting NCT03074136 Phase 2 0.5% Sodium hypochlorite
47 Premedication Efficacy of Ketorolac Infiltration on Post Endodontic Pain Enrolling by invitation NCT02923687 Phase 2 Ketorolac Tromethamine;Placebo
48 Efficacy of Pressure Massage and Topical Gel on Pain During Intra Oral Injections Enrolling by invitation NCT02601924 Phase 2 20% Benzocain (Master-Dent, Monroe, NC)
49 Efficacy of Block Injection of an Anti Inflammatory Medicine in Patients With Mandibular Dental Pain Not yet recruiting NCT03410212 Phase 2 Ketorolac Tromethamine
50 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2

Search NIH Clinical Center for Dental Pulp Disease

Cochrane evidence based reviews: dental pulp diseases

Genetic Tests for Dental Pulp Disease

Anatomical Context for Dental Pulp Disease

MalaCards organs/tissues related to Dental Pulp Disease:

38
Testes, Bone

Publications for Dental Pulp Disease

Articles related to Dental Pulp Disease:

# Title Authors Year
1
Effects of combining CBCT technology with visual root canal recurrence in treatment of elderly patients with dental pulp disease. ( 28338208 )
2017
2
Diagnostic imaging in veterinary dental practice. Dental pulp disease in a river otter. ( 23971840 )
2013

Variations for Dental Pulp Disease

Expression for Dental Pulp Disease

Search GEO for disease gene expression data for Dental Pulp Disease.

Pathways for Dental Pulp Disease

Pathways related to Dental Pulp Disease according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.98 CXCL8 IL1B TNF
2
Show member pathways
11.94 CXCL8 IL1B TNF
3 11.79 CXCL8 IL1B TNF
4 11.76 CXCL8 IL1B TNF
5 11.68 CXCL8 IL1B TNF
6 11.65 CXCL8 IL1B TNF
7 11.63 CXCL8 IL1B TNF
8 11.59 CXCL8 IL1B TNF
9
Show member pathways
11.55 CXCL8 ECSIT IL1B TNF
10 11.49 CXCL8 IL1B TNF
11 11.38 CXCL8 IL1B TNF
12
Show member pathways
11.34 CXCL8 IL1B TNF
13 11.24 CXCL8 IL1B TNF
14 11.14 CXCL8 IL1B TAC1 TNF
15 11.12 CXCL8 IL1B TNF
16 11.08 IL1B TNF
17 11.02 CXCL8 IL1B TNF
18 11 CXCL8 IL1B TNF
19 10.96 CXCL8 TNF
20 10.92 IL1B TNF
21 10.85 CXCL8 TNF
22 10.75 IL1B TNF

GO Terms for Dental Pulp Disease

Cellular components related to Dental Pulp Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 AMELX CXCL8 DSPP IL1B LRRC7 NPS

Biological processes related to Dental Pulp Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.87 AMELX CXCL8 IL1B TNF
2 positive regulation of interleukin-8 production GO:0032757 9.58 IL1B TNF
3 positive regulation of NF-kappaB import into nucleus GO:0042346 9.58 IL1B TNF
4 response to pain GO:0048265 9.56 TAC1 TRPV1
5 embryonic digestive tract development GO:0048566 9.55 CXCL8 TNF
6 negative regulation of lipid catabolic process GO:0050995 9.54 IL1B TNF
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.52 IL1B TNF
8 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.51 IL1B TNF
9 positive regulation of synaptic transmission, GABAergic GO:0032230 9.49 NPS TAC1
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 IL1B TNF
11 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL1B TNF
12 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
13 positive regulation of action potential GO:0045760 9.4 NPS TAC1
14 fever generation GO:0001660 9.37 IL1B TRPV1
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.33 IL1B TNF TRPV1
16 positive regulation of fever generation GO:0031622 9.32 IL1B TNF
17 sequestering of triglyceride GO:0030730 9.26 IL1B TNF
18 inflammatory response GO:0006954 9.02 CXCL8 IL1B TAC1 TNF TRPV1
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IL1B TNF

Sources for Dental Pulp Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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