Aliases & Classifications for Dental Pulp Disease

MalaCards integrated aliases for Dental Pulp Disease:

Name: Dental Pulp Disease 12 14
Dental Pulp Diseases 42 69
Disorder of Pulp of Tooth 12
Dental Pulp Disorder 12
Pulp Disorder 12


External Ids:

Disease Ontology 12 DOID:5330
MeSH 42 D003788
NCIt 47 C34530
SNOMED-CT 64 57203004
UMLS 69 C0011405

Summaries for Dental Pulp Disease

MalaCards based summary : Dental Pulp Disease, also known as dental pulp diseases, is related to insensitivity to pain, congenital and cutaneous porphyria, and has symptoms including toothache An important gene associated with Dental Pulp Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Bacterial infections in CF airways and Immune response IFN alpha/beta signaling pathway. The drugs Epinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and eye.

Related Diseases for Dental Pulp Disease

Diseases related to Dental Pulp Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
id Related Disease Score Top Affiliating Genes
1 insensitivity to pain, congenital 10.7 SCN11A TRPV1
2 cutaneous porphyria 10.6 NPS TRPV1
3 acrocephalopolydactylous dysplasia 10.5 SCN11A TRPV1
4 cryptogenic organizing pneumonia 10.5 TAC1 TRPV1
5 mental retardation, autosomal recessive 54 10.4 NPS TAC1
6 lower clivus meningioma 10.4 DSPP IL1B SASS6
7 oculomotor nerve paralysis 10.4 CXCL8 IL1B
8 neuroschistosomiasis 10.4 AMELX DSPP
9 boutonneuse fever 10.4 NPS TAC1
10 common peroneal nerve lesion 10.4 CXCL8 IL1B
11 lacrimal apparatus disease 10.4 CXCL8 IL1B
12 bronchus cancer 10.4 AMELX DSPP
13 infancy electroclinical syndrome 10.4 CXCL8 IL1B
14 chancroid 10.4 CXCL8 IL1B
15 tabatznik syndrome 10.3 IL1B TNF
16 spinal canal intradural extramedullary neoplasm 10.3 SCN11A TAC1 TRPV1
17 sternal cleft 10.3 IL1B TNF
18 pulmonary hypertension 10.3 IL1B TNF
19 walker dyson syndrome 10.3 IL1B TNF
20 cataract 10.3 IL1B TNF
21 placenta accreta 10.3 IL1B TAC1 TRPV1
22 scrotal carcinoma 10.3 IL1B TNF
23 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.3 IL1B TNF
24 laron dwarfism 10.2 DSPP TAC1
25 upper gum cancer 10.2 IL1B TNF
26 moved to 244450 10.2 IL1B TNF
27 bipolar i disorder 10.2 IL1B TNF
28 fibrosarcomatous osteosarcoma 10.2 CXCL8 IL1B TRPV1
29 subglottis neoplasm 10.2 CXCL8 DSPP IL1B
30 bullous retinoschisis 10.2 CXCL8 DSPP IL1B
31 lung sarcoma 10.2 IL1B TNF
32 retinal dystrophy with inner retinal dysfunction and ganglion cell abnormalities 10.2 CXCL8 IL1B TRPV1
33 carbuncle 10.2 CXCL8 IL1B
34 central nervous system leiomyosarcoma 10.2 IL1B TNF
35 indolent myeloma 10.2 IL1B TNF
36 basidiobolomycosis 10.2 CXCL8 TNF
37 spirillary rat-bite fever 10.2 CXCL8 TNF
38 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.2 IL1B TNF
39 uterine corpus dissecting leiomyoma 10.1 CXCL8 TAC1 TRPV1
40 ileocolitis 10.1 IL1B TNF
41 granuloma inguinale 10.1 CXCL8 NPS
42 brucella canis brucellosis 10.1 IL1B TNF TRPV1
43 tarsal tunnel syndrome 10.1 CXCL8 TNF
44 halal setton wang syndrome 10.1 CXCL8 TNF
45 lymphoma 10.1 IL1B TNF TRPV1
46 plantar wart 10.1 CXCL8 TNF
47 hypertrichosis 10.1 IL1B TNF TRPV1
48 lacrimal system cancer 10.1 IL1B TNF TRPV1
49 survival motor neuron spinal muscular atrophy 10.1 IL1B TNF TRPV1
50 pasteurellosis 10.1 CXCL8 TNF

Graphical network of the top 20 diseases related to Dental Pulp Disease:

Diseases related to Dental Pulp Disease

Symptoms & Phenotypes for Dental Pulp Disease

UMLS symptoms related to Dental Pulp Disease:


Drugs & Therapeutics for Dental Pulp Disease

Drugs for Dental Pulp Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 140)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
3 Racepinephrine Approved Phase 4,Phase 3,Phase 2
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
Tramadol Approved, Investigational Phase 4,Phase 1,Phase 2 27203-92-5 33741
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
12 Anti-Bacterial Agents Phase 4,Phase 2,Phase 1,Early Phase 1
13 Antibiotics, Antitubercular Phase 4,Phase 1,Early Phase 1
14 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
15 Antitubercular Agents Phase 4,Phase 1,Early Phase 1
16 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3
17 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1
18 Anesthetics Phase 4,Phase 3,Phase 2
19 Anesthetics, Local Phase 4,Phase 3,Phase 2
20 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2
21 Carticaine Phase 4,Phase 3,Phase 2
22 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
23 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2
24 Epinephryl borate Phase 4,Phase 3,Phase 2
25 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
26 Sodium Channel Blockers Phase 4,Phase 3,Phase 2
27 Adrenergic Agents Phase 4,Phase 3,Phase 2
28 Adrenergic Agonists Phase 4,Phase 3,Phase 2
29 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
30 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2
31 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
32 Autonomic Agents Phase 4,Phase 3,Phase 2
33 Bronchodilator Agents Phase 4,Phase 3,Phase 2
34 Mydriatics Phase 4,Phase 3,Phase 2
35 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
36 Respiratory System Agents Phase 4,Phase 3,Phase 2
37 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
38 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
39 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1
40 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1
42 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1
43 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
44 Dexketoprofen trometamol Phase 4
45 Antiemetics Phase 4,Phase 3
46 Antineoplastic Agents, Hormonal Phase 4,Phase 3
47 Gastrointestinal Agents Phase 4,Phase 3
48 glucocorticoids Phase 4,Phase 3
49 Hormone Antagonists Phase 4,Phase 3
50 Hormones Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 130)

id Name Status NCT ID Phase Drugs
1 Success Rate Evaluation of Miniature Pulpotomy With MTA in Primary Molars Unknown status NCT02286648 Phase 4 Formocresol;Mineral Trioxide Aggregate
2 Postoperative Pain in Single-visit and Multiple-visit Retreatment Cases Completed NCT03042377 Phase 4 Multiple-Visit-"Calcium Hydroxide";Multiple-Visit-"Corticosteroid Paste";Multiple-Visit-"Antibiotic Paste"
3 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars Completed NCT01496846 Phase 4 Articaine local anesthetic;Lidocaine local anesthetic
4 Anesthetic Efficacy of Articaine and Lidocaine in Lower Molars With Irreversible Pulpits Completed NCT01912755 Phase 4 4% articaine with 1:100,000 epinephrine;2% lidocaine with 1:100,000 epinephrine
5 Dexketoprofen Trometamol in Postoperative Endodontic Pain Completed NCT02086097 Phase 4 Dexketoprofen trometamol;Ibuprofen;PLACEBO
6 Oral Glucocorticoids Effect on Post Endodontic Pain Completed NCT02819648 Phase 4 Prednisolone
7 Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis Completed NCT02110966 Phase 4 Mepivacaine;Mepivacaine plus Tramadol
8 Anesthetic Efficacy in Irreversible Pulpitis Completed NCT02054767 Phase 4 Intervention: inferior alveolar nerve block injection
9 Prefabricated Endodontic Posts: Glass Fiber Versus Titanium - A Randomized Controlled Pilot- Trial Completed NCT01520766 Phase 4
10 Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma Completed NCT01817413 Phase 4
11 Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial Active, not recruiting NCT02201641 Phase 4
12 Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT Enrolling by invitation NCT02702505 Phase 4
13 Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth Completed NCT02492841 Phase 2, Phase 3 Mineral trioxide aggregate;Calcium hydroxide;Biodentine
14 Human Pulpal Response After Pulp Capping With Four Different Agents Completed NCT01468480 Phase 2, Phase 3 Pro Root MTA;Pro Root MTA- single visit;MultiCal;Dycal
15 Partial Pulpotomy on Caries Free Human Teeth Completed NCT01420718 Phase 2, Phase 3 MTA;iRoot BP
16 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis Completed NCT02807298 Phase 3 4%articaine;2% Lignocaine;Epinephrine
17 Pre-operative Aceclofenac on the Anesthetic Efficacy of IANB in Symptomatic Irreversible Pulpitis Completed NCT03146481 Phase 2, Phase 3 Aceclofenac
18 Effect of Inferior Alveolar and Gow-Gates Nerve Block Techniques for Symptomatic Mandibular Molars Completed NCT03117491 Phase 3
19 Effect of Sodium Bicarbonate Buffered Lidocaine on the Success of IAN Block of Teeth With Irreversible Pulpitis Completed NCT02226913 Phase 3 2% lidocaine with 1:80,000 epinephrine;sodium bicarbonate;placebo
20 Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth Completed NCT00472173 Phase 3 Mineral Trioxide Aggregate;Calcium hydroxide
21 Effect of Preoperative Diclofenac Potassium on Articaine Buccal Infitration Success Recruiting NCT03174860 Phase 2, Phase 3 Diclofenac Potassium 50mg Tab;Placebo
22 Clinical Comparison of Endodontically Treated Teeth Restored With Fiber Posts or Cast Metal Posts Recruiting NCT01461239 Phase 3
23 Efficacy of Oral Prednisolone on Pain Reduction in Emergency Care of Acute Irreversible Pulpitis Recruiting NCT02629042 Phase 3 prednisolone
24 Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy Recruiting NCT03084601 Phase 2, Phase 3 Calcium Hydroxide, Iodoform, paste;3-mixtatin
25 Diclofenac Potassium on IANB Efficacy in Symptomatic Irreversible Pulpitis Active, not recruiting NCT03163420 Phase 2, Phase 3 Diclofenac potassium
26 Regenerative Endodontic Procedure of Immature Permanent Teeth With L-PRF: a Pilot Controlled, Clinical Trial Active, not recruiting NCT02437708 Phase 3
27 A Clinical Study: the Antibacterial Effect of Insoluble Antibacterial Nanoparticles (IABN) Incorporated in Dental Materials for Root Canal Treatment Unknown status NCT01167985 Phase 2
28 Periodontal Regeneration of Chronic Periodontal Disease Patients Receiving Stem Cells Injection Therapy Unknown status NCT02523651 Phase 1, Phase 2
29 Effect Of Different Lining Materials in Stepwise Excavation Unknown status NCT01730287 Phase 2 Control;Calcium Hydroxide;Mineral Trioxide Aggregate(MTA);CEM cement
30 Efficacy of Chlorexidine as Intracanal Medicament in Primary Teeth Unknown status NCT00624572 Phase 2 chlorexidine
31 Photodynamic Therapy in Endodontic Treatment Completed NCT02824601 Phase 2 Calcium hydroxide
32 Effect of Sufentanil on the Rate of Anesthesia Completed NCT01572116 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + sufentanil
33 Endodontic Treatment of Primary Teeth Using Mineral Trioxide Aggregate Paste Completed NCT02887456 Phase 2 Endodontic treatment using Vitapex;Endodontic treatment using MTA paste
34 Effect of Premedication on Success of Inferior Alveolar Nerve Block Injection Completed NCT02601911 Phase 2 Ketorolac Tromethamine;Acetaminophen
35 Premedication Efficacy of Oral Ketorolac and Ketorolac/ Acetaminophen on Post Treatment Pain Completed NCT02614118 Phase 2 Ketorolac tromethamine;Acetaminophen;Placebo
36 The Effects of Three Oral Medications on Post-operative Pain Following Endodontic Treatment Completed NCT01178203 Phase 1, Phase 2 Placebo;Tramadol;Novafen;Naproxen
37 Effect of Fentanyl on the Rate of Anesthesia Completed NCT01794533 Phase 2 Lidocaine with Epinephrine+ Normal saline;Lidocaine with Epinephrine + fentanyl
38 MTA/FS Pulpotomy for Vital Primary Incisors: A Randomized Controlled Trial Completed NCT02019563 Phase 2
39 Chlorhexidine Intracanal Medicament in Periodontal Healing in Concomitant Endo Perio Lesion With Communication Completed NCT02627326 Phase 2
40 Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth Completed NCT02625298 Phase 2
41 Efficacy of Different Drugs to Control Post Root Canal Treatment Pain Completed NCT02417337 Phase 2 Paracetamol;Ibuprofen;Mefenamic acid;Diclofenac
42 A Clinical Study to Compare Two Revascularization Protocols to Treat Non-vital Teeth With Incomplete Root Formation Recruiting NCT01827098 Phase 2
43 Application of Photodynamic Therapy and Diode Laser for Endodontic Therapy of Young Permanent Teeth Recruiting NCT03074136 Phase 2 0.5% Sodium hypochlorite
44 Effect of High-dose Naloxone Following Third Molar Extraction Recruiting NCT02976337 Phase 2 Naloxone;Normal Saline
45 Premedication Efficacy of Ketorolac Infiltration on Post Endodontic Pain Enrolling by invitation NCT02923687 Phase 2 Ketorolac Tromethamine;Placebo
46 Efficacy of Pressure Massage and Topical Gel on Pain During Intra Oral Injections Enrolling by invitation NCT02601924 Phase 2 20% Benzocain (Master-Dent, Monroe, NC)
47 Dose-response Evaluation of the Cellavita HD Product in Patients With Huntington's Disease Not yet recruiting NCT03252535 Phase 2
48 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
49 Photodynamic Therapy (PDT) for Oral Disinfection Completed NCT02152475 Phase 1 mouthwash with curcumin
50 Effectiveness of Photodynamic Therapy for Endodontic Treatment of Deciduous Teeth Recruiting NCT02485210 Phase 1

Search NIH Clinical Center for Dental Pulp Disease

Cochrane evidence based reviews: dental pulp diseases

Genetic Tests for Dental Pulp Disease

Anatomical Context for Dental Pulp Disease

MalaCards organs/tissues related to Dental Pulp Disease:

Testes, Bone, Eye

Publications for Dental Pulp Disease

Articles related to Dental Pulp Disease:

id Title Authors Year
Effects of combining CBCT technology with visual root canal recurrence in treatment of elderly patients with dental pulp disease. ( 28338208 )
Diagnostic imaging in veterinary dental practice. Dental pulp disease in a river otter. ( 23971840 )

Variations for Dental Pulp Disease

Expression for Dental Pulp Disease

Search GEO for disease gene expression data for Dental Pulp Disease.

Pathways for Dental Pulp Disease

Pathways related to Dental Pulp Disease according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
Show member pathways
11.98 CXCL8 IL1B TNF
Show member pathways
11.94 CXCL8 IL1B TNF
3 11.79 CXCL8 IL1B TNF
4 11.76 CXCL8 IL1B TNF
5 11.68 CXCL8 IL1B TNF
6 11.65 CXCL8 IL1B TNF
7 11.63 CXCL8 IL1B TNF
8 11.59 CXCL8 IL1B TNF
Show member pathways
10 11.49 CXCL8 IL1B TNF
11 11.38 CXCL8 IL1B TNF
Show member pathways
11.34 CXCL8 IL1B TNF
13 11.24 CXCL8 IL1B TNF
14 11.14 CXCL8 IL1B TAC1 TNF
15 11.12 CXCL8 IL1B TNF
16 11.08 IL1B TNF
17 11.02 CXCL8 IL1B TNF
18 11 CXCL8 IL1B TNF
19 10.96 CXCL8 TNF
20 10.92 IL1B TNF
21 10.85 CXCL8 TNF
22 10.75 IL1B TNF

GO Terms for Dental Pulp Disease

Cellular components related to Dental Pulp Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 AMELX CXCL8 DSPP IL1B LRRC7 NPS

Biological processes related to Dental Pulp Disease according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of phagocytosis GO:0050766 9.58 IL1B TNF
2 positive regulation of interleukin-8 production GO:0032757 9.58 IL1B TNF
3 positive regulation of NF-kappaB import into nucleus GO:0042346 9.57 IL1B TNF
4 response to pain GO:0048265 9.56 TAC1 TRPV1
5 embryonic digestive tract development GO:0048566 9.55 CXCL8 TNF
6 negative regulation of lipid catabolic process GO:0050995 9.54 IL1B TNF
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.52 IL1B TNF
8 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.51 IL1B TNF
9 positive regulation of synaptic transmission, GABAergic GO:0032230 9.49 NPS TAC1
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 IL1B TNF
11 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL1B TNF
12 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
13 positive regulation of action potential GO:0045760 9.4 NPS TAC1
14 fever generation GO:0001660 9.37 IL1B TRPV1
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.33 IL1B TNF TRPV1
16 positive regulation of fever generation GO:0031622 9.32 IL1B TNF
17 sequestering of triglyceride GO:0030730 9.26 IL1B TNF
18 inflammatory response GO:0006954 9.02 CXCL8 IL1B TAC1 TNF TRPV1
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IL1B TNF

Sources for Dental Pulp Disease

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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