MCID: DNT006
MIFTS: 27

Dental Pulp Necrosis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Pulp Necrosis

MalaCards integrated aliases for Dental Pulp Necrosis:

Name: Dental Pulp Necrosis 12 42 14 69
Pulp Necrosis 12 52
Necrosis of the Pulp Nos 12
Necrosis of the Pulp 12
Necrotic Pulp 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11623
ICD10 33 K04.1
ICD9CM 35 522.1
MeSH 42 D003790
UMLS 69 C0011407

Summaries for Dental Pulp Necrosis

MalaCards based summary : Dental Pulp Necrosis, also known as pulp necrosis, is related to lower clivus meningioma and ocular cancer. An important gene associated with Dental Pulp Necrosis is DSPP (Dentin Sialophosphoprotein). The drugs Chloramphenicol and Tetracycline have been mentioned in the context of this disorder. Affiliated tissues include bone.

Wikipedia : 72 Necrotic pulp is a finding in dentistry to describe dental pulp within a tooth which has become... more...

Related Diseases for Dental Pulp Necrosis

Graphical network of the top 20 diseases related to Dental Pulp Necrosis:



Diseases related to Dental Pulp Necrosis

Symptoms & Phenotypes for Dental Pulp Necrosis

Drugs & Therapeutics for Dental Pulp Necrosis

Drugs for Dental Pulp Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chloramphenicol Approved, Vet_approved Phase 4 56-75-7 298 5959
2
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
3
Zinc Approved Phase 4,Phase 1,Early Phase 1 7440-66-6 32051 23994
4
Zinc oxide Approved Phase 4 1314-13-2
5
Ceftibuten Approved Phase 4 97519-39-6 5282241 5282242
6
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
8
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
9
Salicylic acid Approved, Vet_approved Phase 4 69-72-7 338
10
Chloramphenicol succinate Experimental Phase 4 3544-94-3
11 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
12 Calcium, Dietary Phase 4,Phase 3,Phase 2
13 Anesthetics Phase 4,Phase 2,Phase 1
14 Anti-Bacterial Agents Phase 4,Phase 1,Early Phase 1
15 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
16 Antiemetics Phase 4
17 Anti-Infective Agents, Local Phase 4,Phase 1,Early Phase 1
18 Anti-Inflammatory Agents Phase 4,Phase 2
19 Antineoplastic Agents, Hormonal Phase 4
20 Autonomic Agents Phase 4
21 BB 1101 Phase 4
22 Chlorhexidine gluconate Phase 4
23 Dermatologic Agents Phase 4
24 Dexamethasone acetate Phase 4 1177-87-3
25 Gastrointestinal Agents Phase 4
26 glucocorticoids Phase 4
27 HIV Protease Inhibitors Phase 4
28 Hormone Antagonists Phase 4
29 Hormones Phase 4
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
31 Peripheral Nervous System Agents Phase 4,Phase 2
32
protease inhibitors Phase 4
33 Antibiotics, Antitubercular Phase 4,Phase 1,Early Phase 1
34
Ciprofloxacin Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 85721-33-1 2764
35
Metronidazole Approved Phase 2, Phase 3,Phase 1,Early Phase 1 443-48-1 4173
36
Cefixime Approved Phase 2, Phase 3 79350-37-1 54362 5362065
37
Simvastatin Approved Phase 2, Phase 3 79902-63-9 54454
38 Disinfectants Phase 2, Phase 3
39
Acetaminophen Approved Phase 2 103-90-2 1983
40
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
41
Ibuprofen Approved Phase 2 15687-27-1 3672
42
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
43 Racepinephrine Approved Phase 2,Phase 1
44 Analgesics Phase 2
45 Analgesics, Non-Narcotic Phase 2
46 Anti-Inflammatory Agents, Non-Steroidal Phase 2
47 Antipyretics Phase 2
48 Antirheumatic Agents Phase 2
49 Cyclooxygenase Inhibitors Phase 2
50 Epinephryl borate Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 53)

id Name Status NCT ID Phase Drugs
1 Antimicrobial Pulpotomy of Primary Molars Completed NCT01010451 Phase 4
2 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4 Dexamethasone applied on pulp or Dexamethasone did not applied on pulp
3 Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma Completed NCT01817413 Phase 4
4 Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth Completed NCT00472173 Phase 3 Mineral Trioxide Aggregate;Calcium hydroxide
5 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries Completed NCT00495495 Phase 2, Phase 3
6 Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy Recruiting NCT03084601 Phase 2, Phase 3 Calcium Hydroxide, Iodoform, paste;3-mixtatin
7 Endodontic Treatment of Necrotic Primary Teeth With Guedes Pinto Paste: A Randomized Clinical Trial Active, not recruiting NCT02216942 Phase 3 Endodontic treatment using Vitapex;Endodontic treatment using Guedes Pinto
8 Efficacy of Chlorexidine as Intracanal Medicament in Primary Teeth Unknown status NCT00624572 Phase 2 chlorexidine
9 Effect Of Different Lining Materials in Stepwise Excavation Unknown status NCT01730287 Phase 2 Control;Calcium Hydroxide;Mineral Trioxide Aggregate(MTA);CEM cement
10 Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth Completed NCT02625298 Phase 2
11 Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment. Completed NCT02815189 Phase 2 Acetaminophen 325 mg for Flare up
12 A Clinical Study to Compare Two Revascularization Protocols to Treat Non-vital Teeth With Incomplete Root Formation Recruiting NCT01827098 Phase 2
13 Application of Photodynamic Therapy and Diode Laser for Endodontic Therapy of Young Permanent Teeth Recruiting NCT03074136 Phase 2 0.5% Sodium hypochlorite
14 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
15 Foraminal Enlargement and Postoperative Pain. Completed NCT02770053 Phase 1
16 Apical Patency and Postoperative Pain. Completed NCT02768285 Phase 1
17 Accuracy of ERCLMDs in Teeth With Apical Periodontitis Completed NCT01904552 Phase 1
18 Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots Recruiting NCT01976065 Phase 1 Triple Antibiotic Paste
19 Partial Removal of Caries Dentines Unknown status NCT00887952
20 Tissue Characterization in Teeth Treated With a Regeneration Protocol Completed NCT00881907 Early Phase 1 Triple Antibiotic Paste;Triple Antibiotic Paste;Triple Antibiotic Paste
21 Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste Completed NCT00881491 Early Phase 1 Double Antibiotic Paste;Triple Antibiotic Paste;Mineral Trioxide Aggregate
22 Measurement of Bite Force in Humans Completed NCT00223327 Early Phase 1
23 Pulp Revascularization Versus MTA Apexification Completed NCT03083015
24 Incidence of Post-operative Pain After Single-visit Versus Two-visit Treatment Completed NCT03120845
25 Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients Completed NCT01312194
26 Antimicrobial Pastes and Clinical Cases of Apexogenesis Completed NCT03112291
27 Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches Completed NCT01870973
28 Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth Completed NCT00595595
29 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
30 Postoperative Pain of Root Canal Therapy With Three Techniques Completed NCT02442388
31 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513
32 Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study Completed NCT03212729
33 Effect of Different Instrumentation Technique on Endodontic Outcome Completed NCT03278054
34 Effect of Smear Layer on Endodontic Outcome Completed NCT03277404
35 Efficacy and the Safety Study of RD94 in Patients With Endodontic Care Completed NCT01737229
36 Revitalization of Immature Permanent Teeth With Necrotic Pulps Using SHED Cells Recruiting NCT01814436
37 Comparison Between Reciproc and Protaper Next Recruiting NCT02946099
38 Reciprocation vs Rotational Single-file Systems in Postoperative Pain Recruiting NCT02929511
39 Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material Recruiting NCT02698163
40 Research of Revascularization in Immature Teeth With Periapical Periodontitis Recruiting NCT01799187
41 A Telephone-based Case-management Intervention for Caries Prevention in Children With Severe Early Childhood Caries Recruiting NCT02487043
42 Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment Recruiting NCT02681276
43 Apical Size and Root Canal Treatment Success Trial (AS-RCT Trial) Recruiting NCT03053037
44 Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inflammation Recruiting NCT02967081
45 The Occlusive Dressing Recruiting NCT01002638
46 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment Active, not recruiting NCT03288467
47 Comparing Between XP Endo Finisher and Conventional Irrigation Method On Post-Operative Flare Ups In Necrotic Teeth Not yet recruiting NCT02952326
48 Postoperative Pain Following Treatment of Asymptomatic Necrotic Mandibular Molars in Single Visit Using Wave-one Reciprocating Instruments Versus One-Shape Rotary Instruments Not yet recruiting NCT03301259
49 Post Operative Pain and Level of Endotoxins With Calcium Hydroxide and Calcium Hydroxide Mixed With Chlorhexidine in Treating Necrotic Teeth Not yet recruiting NCT03009006 Chlorhexidine 2% gel - Calcium Hydroxide Paste - Non-Setting;Calcium Hydroxide Paste - Non-Setting
50 Incidence of Post-Operative Pain After Single Visit Root Canal Treatment in Necrotic Teeth Using Two Different Rotary Systems (Protaper Nex t& Neolix File) Not yet recruiting NCT03059290

Search NIH Clinical Center for Dental Pulp Necrosis

Cochrane evidence based reviews: dental pulp necrosis

Genetic Tests for Dental Pulp Necrosis

Anatomical Context for Dental Pulp Necrosis

MalaCards organs/tissues related to Dental Pulp Necrosis:

39
Bone

Publications for Dental Pulp Necrosis

Articles related to Dental Pulp Necrosis:

id Title Authors Year
1
Dental pulp necrosis as a rare complication of reduction malarplasty. ( 17667692 )
2007

Variations for Dental Pulp Necrosis

Expression for Dental Pulp Necrosis

Search GEO for disease gene expression data for Dental Pulp Necrosis.

Pathways for Dental Pulp Necrosis

GO Terms for Dental Pulp Necrosis

Cellular components related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 8.92 AMBN AMELX AMELY DSPP

Biological processes related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.71 AMELX AMELY BMP2 DSPP
2 ossification GO:0001503 9.37 BMP2 DSPP
3 odontogenesis of dentin-containing tooth GO:0042475 9.33 AMBN AMELX BMP2
4 chondrocyte differentiation GO:0002062 9.32 AMELX BMP2
5 epithelial to mesenchymal transition GO:0001837 9.26 AMELX BMP2
6 tooth mineralization GO:0034505 8.96 AMELX AMELY
7 biomineral tissue development GO:0031214 8.92 AMBN AMELX AMELY DSPP

Molecular functions related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 AMBN AMELX BMP2
2 structural constituent of tooth enamel GO:0030345 8.8 AMBN AMELX AMELY

Sources for Dental Pulp Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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