Dental Pulp Necrosis malady

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Pulp Necrosis

Aliases & Descriptions for Dental Pulp Necrosis:

Name: Dental Pulp Necrosis 12 42 14 69
Pulp Necrosis 12 52
Necrosis of the Pulp Nos 12
Necrosis of the Pulp 12
Necrotic Pulp 12


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Disease Ontology 12 DOID:11623
ICD10 33 K04.1
ICD9CM 35 522.1
MeSH 42 D003790
UMLS 69 C0011407

Summaries for Dental Pulp Necrosis

MalaCards based summary : Dental Pulp Necrosis, also known as pulp necrosis, is related to bulbomembranous urethral cancer and retinitis pigmentosa 59. An important gene associated with Dental Pulp Necrosis is DSPP (Dentin Sialophosphoprotein). The drugs Chloramphenicol and Tetracycline have been mentioned in the context of this disorder.

Related Diseases for Dental Pulp Necrosis

Graphical network of the top 20 diseases related to Dental Pulp Necrosis:

Diseases related to Dental Pulp Necrosis

Symptoms & Phenotypes for Dental Pulp Necrosis

Drugs & Therapeutics for Dental Pulp Necrosis

Drugs for Dental Pulp Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Chloramphenicol Approved, Vet_approved Phase 4 56-75-7 298 5959
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
Zinc Approved Phase 4,Phase 1,Early Phase 1 7440-66-6 32051 23994
Zinc oxide Approved Phase 4 1314-13-2
Ceftibuten Approved Phase 4 97519-39-6 5282241 5282242
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
Salicylic acid Approved, Vet_approved Phase 4 69-72-7 338
10 Chloramphenicol succinate Experimental Phase 4
11 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
12 Calcium, Dietary Phase 4,Phase 3,Phase 2
13 Anesthetics Phase 4,Phase 2,Phase 1
14 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Early Phase 1
15 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
16 Antiemetics Phase 4
17 Anti-Infective Agents, Local Phase 4,Phase 1,Early Phase 1
18 Anti-Inflammatory Agents Phase 4,Phase 2
19 Antineoplastic Agents, Hormonal Phase 4
20 Autonomic Agents Phase 4
21 BB 1101 Phase 4
22 Chlorhexidine gluconate Phase 4
23 Dermatologic Agents Phase 4
24 Dexamethasone 21-phosphate Phase 4
25 Dexamethasone acetate Phase 4 1177-87-3
26 Gastrointestinal Agents Phase 4
27 glucocorticoids Phase 4
28 HIV Protease Inhibitors Phase 4
29 Hormone Antagonists Phase 4
30 Hormones Phase 4
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
32 Peripheral Nervous System Agents Phase 4,Phase 2
protease inhibitors Phase 4
34 Antibiotics, Antitubercular Phase 4,Phase 1,Early Phase 1
Ciprofloxacin Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 85721-33-1 2764
Metronidazole Approved Phase 2, Phase 3,Phase 1,Early Phase 1 443-48-1 4173
Cefixime Approved Phase 2, Phase 3 79350-37-1 54362 5362065
Simvastatin Approved Phase 2, Phase 3 79902-63-9 54454
39 Disinfectants Phase 2, Phase 3
Acetaminophen Approved Phase 2 103-90-2 1983
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
Ibuprofen Approved Phase 2 15687-27-1 3672
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
44 Analgesics Phase 2
45 Analgesics, Non-Narcotic Phase 2
46 Anti-Inflammatory Agents, Non-Steroidal Phase 2
47 Antipyretics Phase 2
48 Antirheumatic Agents Phase 2
49 Cyclooxygenase Inhibitors Phase 2
50 Epinephryl borate Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 52)
id Name Status NCT ID Phase
1 Antimicrobial Pulpotomy of Primary Molars Completed NCT01010451 Phase 4
2 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4
3 Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma Completed NCT01817413 Phase 4
4 Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth Completed NCT00472173 Phase 3
5 Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth Completed NCT02625298 Phase 2, Phase 3
6 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries Completed NCT00495495 Phase 2, Phase 3
7 Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy Recruiting NCT03084601 Phase 2, Phase 3
8 Multicenter Trial Comparing One-step Partial Caries Removal to Complete Caries Removal for the Treatment of Deep Carious Lesions in Permanent Teeth. (DECAT : DEep CAries Treatment). Recruiting NCT02286388 Phase 3
9 Endodontic Treatment of Necrotic Primary Teeth With Guedes Pinto Paste: A Randomized Clinical Trial Active, not recruiting NCT02216942 Phase 3
10 Efficacy of Chlorexidine as Intracanal Medicament in Primary Teeth Unknown status NCT00624572 Phase 2
11 Effect Of Different Lining Materials in Stepwise Excavation Unknown status NCT01730287 Phase 2
12 Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment. Completed NCT02815189 Phase 2
13 A Clinical Study to Compare Two Revascularization Protocols to Treat Non-vital Teeth With Incomplete Root Formation Recruiting NCT01827098 Phase 2
14 Application of Photodynamic Therapy and Diode Laser for Endodontic Therapy of Young Permanent Teeth Recruiting NCT03074136 Phase 2
15 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
16 Foraminal Enlargement and Postoperative Pain. Completed NCT02770053 Phase 1
17 Apical Patency and Postoperative Pain. Completed NCT02768285 Phase 1
18 Accuracy of ERCLMDs in Teeth With Apical Periodontitis Completed NCT01904552 Phase 1
19 Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots Recruiting NCT01976065 Phase 1
20 Partial Removal of Caries Dentines Unknown status NCT00887952
21 Tissue Characterization in Teeth Treated With a Regeneration Protocol Completed NCT00881907 Early Phase 1
22 Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste Completed NCT00881491 Early Phase 1
23 Measurement of Bite Force in Humans Completed NCT00223327 Early Phase 1
24 Pulp Revascularization Versus MTA Apexification Completed NCT03083015
25 Incidence of Post-operative Pain After Single-visit Versus Two-visit Treatment Completed NCT03120845
26 Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients Completed NCT01312194
27 Antimicrobial Pastes and Clinical Cases of Apexogenesis Completed NCT03112291
28 Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches Completed NCT01870973
29 Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth Completed NCT00595595
30 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
31 Postoperative Pain of Root Canal Therapy With Three Techniques Completed NCT02442388
32 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513
33 Efficacy and the Safety Study of RD94 in Patients With Endodontic Care Completed NCT01737229
34 Revitalization of Immature Permanent Teeth With Necrotic Pulps Using SHED Cells Recruiting NCT01814436
35 Comparison Between Reciproc and Protaper Next Recruiting NCT02946099
36 Reciprocation vs Rotational Single-file Systems in Postoperative Pain Recruiting NCT02929511
37 Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material Recruiting NCT02698163
38 Research of Revascularization in Immature Teeth With Periapical Periodontitis Recruiting NCT01799187
39 A Telephone-based Case-management Intervention for Caries Prevention in Children With Severe Early Childhood Caries Recruiting NCT02487043
40 Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment Recruiting NCT02681276
41 Apical Size and Root Canal Treatment Success Trial (AS-RCT Trial) Recruiting NCT03053037
42 Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inflammation Recruiting NCT02967081
43 The Occlusive Dressing Recruiting NCT01002638
44 Evaluation of Post-endodontic Pain After Root Canal Treatment With Two Rotary Systems : Mtwo & Safe-sider Recruiting NCT02644031
45 Influence of Working Length Methods in the Performance of Pulpectomies in Primary Teeth Recruiting NCT03161639
46 Evaluation of Antimicrobial Photodynamic Therapy for the Treatment of Deep Carious Lesions in Children: an in Vivo Study Active, not recruiting NCT02908789
47 Comparing Between XP Endo Finisher and Conventional Irrigation Method On Post-Operative Flare Ups In Necrotic Teeth Not yet recruiting NCT02952326
48 Post Operative Pain and Level of Endotoxins With Calcium Hydroxide and Calcium Hydroxide Mixed With Chlorhexidine in Treating Necrotic Teeth Not yet recruiting NCT03009006
49 Incidence of Post-Operative Pain After Single Visit Root Canal Treatment in Necrotic Teeth Using Two Different Rotary Systems (Protaper Nex t& Neolix File) Not yet recruiting NCT03059290
50 Effect of Diode Laser Activated Irrigation Versus Ultrasonic on Post-Operative Pain in Single Visit of Necrotic Teeth Not yet recruiting NCT03015987

Search NIH Clinical Center for Dental Pulp Necrosis

Cochrane evidence based reviews: dental pulp necrosis

Genetic Tests for Dental Pulp Necrosis

Anatomical Context for Dental Pulp Necrosis

Publications for Dental Pulp Necrosis

Articles related to Dental Pulp Necrosis:

id Title Authors Year
Dental pulp necrosis as a rare complication of reduction malarplasty. ( 17667692 )

Variations for Dental Pulp Necrosis

Expression for Dental Pulp Necrosis

Search GEO for disease gene expression data for Dental Pulp Necrosis.

Pathways for Dental Pulp Necrosis

GO Terms for Dental Pulp Necrosis

Cellular components related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 8.92 AMBN AMELX AMELY DSPP

Biological processes related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.56 AMELX AMELY DSPP FGF2
2 odontogenesis of dentin-containing tooth GO:0042475 9.16 AMBN AMELX
3 tooth mineralization GO:0034505 8.96 AMELX AMELY
4 biomineral tissue development GO:0031214 8.92 AMBN AMELX AMELY DSPP

Molecular functions related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 AMBN AMELX FGF2
2 structural constituent of tooth enamel GO:0030345 8.8 AMBN AMELX AMELY

Sources for Dental Pulp Necrosis

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
65 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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