MCID: DNT006
MIFTS: 29

Dental Pulp Necrosis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Dental Pulp Necrosis

MalaCards integrated aliases for Dental Pulp Necrosis:

Name: Dental Pulp Necrosis 12 41 14 69
Pulp Necrosis 12 51
Necrosis of the Pulp Nos 12
Necrosis of the Pulp 12
Necrotic Pulp 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11623
ICD10 32 K04.1
ICD9CM 34 522.1
MeSH 41 D003790
UMLS 69 C0011407

Summaries for Dental Pulp Necrosis

MalaCards based summary : Dental Pulp Necrosis, also known as pulp necrosis, is related to enamel caries and epulis. An important gene associated with Dental Pulp Necrosis is DSPP (Dentin Sialophosphoprotein). The drugs Ceftibuten and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include bone.

Wikipedia : 72 Necrotic pulp is a finding in dentistry to describe dental pulp within a tooth which has become... more...

Related Diseases for Dental Pulp Necrosis

Graphical network of the top 20 diseases related to Dental Pulp Necrosis:



Diseases related to Dental Pulp Necrosis

Symptoms & Phenotypes for Dental Pulp Necrosis

Drugs & Therapeutics for Dental Pulp Necrosis

Drugs for Dental Pulp Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftibuten Approved, Investigational Phase 4 97519-39-6 5282242 5282241
2
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
5
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
6
Chloramphenicol Approved, Vet_approved Phase 4 56-75-7 5959 298
7
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
8
Zinc Approved, Investigational Phase 4,Phase 1,Early Phase 1 7440-66-6 32051 23994
9
Zinc oxide Approved Phase 4 1314-13-2
10
Chloramphenicol succinate Experimental Phase 4 3544-94-3
11 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
12 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
13 Calcium, Dietary Phase 4,Phase 3,Phase 2
14 Anesthetics Phase 4,Phase 2,Phase 1
15 Antiemetics Phase 4
16 Anti-Infective Agents, Local Phase 4,Phase 1,Early Phase 1
17 Anti-Inflammatory Agents Phase 4,Phase 2
18 Antineoplastic Agents, Hormonal Phase 4
19 Autonomic Agents Phase 4
20 BB 1101 Phase 4
21 Chlorhexidine gluconate Phase 4
22 Dermatologic Agents Phase 4
23 Dexamethasone acetate Phase 4 1177-87-3
24 Gastrointestinal Agents Phase 4
25 glucocorticoids Phase 4
26 HIV Protease Inhibitors Phase 4
27 Hormone Antagonists Phase 4
28 Hormones Phase 4
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
30 Peripheral Nervous System Agents Phase 4,Phase 2
31
protease inhibitors Phase 4
32 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
33 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
34
Ciprofloxacin Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 85721-33-1 2764
35
Metronidazole Approved Phase 2, Phase 3,Phase 1,Early Phase 1 443-48-1 4173
36
Cefixime Approved, Investigational Phase 2, Phase 3 79350-37-1 5362065 54362
37
Simvastatin Approved Phase 2, Phase 3 79902-63-9 54454
38
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613 2171
39 Disinfectants Phase 2, Phase 3
40
Acetaminophen Approved Phase 2 103-90-2 1983
41
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
42
Ibuprofen Approved Phase 2 15687-27-1 3672
43
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
44 Racepinephrine Approved Phase 2,Phase 1 329-65-7
45 Eusol Phase 2,Phase 1
46 Sodium hypochlorite Phase 2,Phase 1
47 Analgesics Phase 2
48 Analgesics, Non-Narcotic Phase 2
49 Anti-Inflammatory Agents, Non-Steroidal Phase 2
50 Antipyretics Phase 2

Interventional clinical trials:

(show all 49)

# Name Status NCT ID Phase Drugs
1 Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp Completed NCT02574468 Phase 4 Dexamethasone applied on pulp or Dexamethasone did not applied on pulp
2 Antimicrobial Pulpotomy of Primary Molars Completed NCT01010451 Phase 4
3 Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma Completed NCT01817413 Phase 4
4 Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth Completed NCT00472173 Phase 3 Mineral Trioxide Aggregate;Calcium hydroxide
5 Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy Recruiting NCT03084601 Phase 2, Phase 3 Calcium Hydroxide, Iodoform, paste;3-mixtatin
6 Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy Recruiting NCT03376984 Phase 2, Phase 3
7 Efficacy of Chlorexidine as Intracanal Medicament in Primary Teeth Unknown status NCT00624572 Phase 2 chlorexidine
8 Effect Of Different Lining Materials in Stepwise Excavation Unknown status NCT01730287 Phase 2 Control;Calcium Hydroxide;Mineral Trioxide Aggregate(MTA);CEM cement
9 Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth Completed NCT02625298 Phase 2
10 Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment. Completed NCT02815189 Phase 2 Acetaminophen 325 mg for Flare up
11 A Clinical Study to Compare Two Revascularization Protocols to Treat Non-vital Teeth With Incomplete Root Formation Recruiting NCT01827098 Phase 2
12 Application of Photodynamic Therapy and Diode Laser for Endodontic Therapy of Young Permanent Teeth Active, not recruiting NCT03074136 Phase 2 0.5% Sodium hypochlorite
13 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
14 Foraminal Enlargement and Postoperative Pain. Completed NCT02770053 Phase 1
15 Apical Patency and Postoperative Pain. Completed NCT02768285 Phase 1
16 Accuracy of ERCLMDs in Teeth With Apical Periodontitis Completed NCT01904552 Phase 1
17 Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots Recruiting NCT01976065 Phase 1 Triple Antibiotic Paste
18 Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment Unknown status NCT02681276
19 Tissue Characterization in Teeth Treated With a Regeneration Protocol Completed NCT00881907 Early Phase 1 Triple Antibiotic Paste;Triple Antibiotic Paste;Triple Antibiotic Paste
20 Comparison Between Reciproc and Protaper Next Completed NCT02946099
21 Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste Completed NCT00881491 Early Phase 1 Double Antibiotic Paste;Triple Antibiotic Paste;Mineral Trioxide Aggregate
22 Measurement of Bite Force in Humans Completed NCT00223327 Early Phase 1
23 Incidence of Post-operative Pain After Single-visit Versus Two-visit Treatment Completed NCT03120845
24 Pulp Revascularization Versus MTA Apexification Completed NCT03083015
25 Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients Completed NCT01312194
26 Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches Completed NCT01870973
27 Antimicrobial Pastes and Clinical Cases of Apexogenesis Completed NCT03112291
28 Postoperative Pain of Root Canal Therapy With Three Techniques Completed NCT02442388
29 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
30 Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth Completed NCT00595595
31 Effect of Different Instrumentation Technique on Endodontic Outcome Completed NCT03278054
32 Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study Completed NCT03212729
33 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513
34 Effect of Smear Layer on Endodontic Outcome Completed NCT03277404
35 Efficacy and the Safety Study of RD94 in Patients With Endodontic Care Completed NCT01737229
36 Revitalization of Immature Permanent Teeth With Necrotic Pulps Using SHED Cells Recruiting NCT01814436
37 Postoperative Pain and PTN and Reciproc Recruiting NCT03380585
38 Reciprocation vs Rotational Single-file Systems in Postoperative Pain Recruiting NCT02929511
39 Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material Recruiting NCT02698163
40 Research of Revascularization in Immature Teeth With Periapical Periodontitis Recruiting NCT01799187
41 A Telephone-based Case-management Intervention for Caries Prevention in Children With Severe Early Childhood Caries Recruiting NCT02487043
42 Apical Size and Root Canal Treatment Success Trial (AS-RCT Trial) Recruiting NCT03053037
43 Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inflammation Recruiting NCT02967081
44 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment Active, not recruiting NCT03288467
45 Comparing Between XP Endo Finisher and Conventional Irrigation Method On Post-Operative Flare Ups In Necrotic Teeth Not yet recruiting NCT02952326
46 Postoperative Pain Following Treatment of Asymptomatic Necrotic Mandibular Molars in Single Visit Using Wave-one Reciprocating Instruments Versus One-Shape Rotary Instruments Not yet recruiting NCT03301259
47 Post Operative Pain and Level of Endotoxins With Calcium Hydroxide and Calcium Hydroxide Mixed With Chlorhexidine in Treating Necrotic Teeth Not yet recruiting NCT03009006 Chlorhexidine 2% gel - Calcium Hydroxide Paste - Non-Setting;Calcium Hydroxide Paste - Non-Setting
48 Incidence of Post-Operative Pain After Single Visit Root Canal Treatment in Necrotic Teeth Using Two Different Rotary Systems (Protaper Nex t& Neolix File) Not yet recruiting NCT03059290
49 Revitalization of Teeth With Necrotic Pulps and Open Apexes Using Platelet-Rich Plasma Terminated NCT01212939

Search NIH Clinical Center for Dental Pulp Necrosis

Cochrane evidence based reviews: dental pulp necrosis

Genetic Tests for Dental Pulp Necrosis

Anatomical Context for Dental Pulp Necrosis

MalaCards organs/tissues related to Dental Pulp Necrosis:

38
Bone

Publications for Dental Pulp Necrosis

Articles related to Dental Pulp Necrosis:

# Title Authors Year
1
Dental pulp necrosis as a rare complication of reduction malarplasty. ( 17667692 )
2007

Variations for Dental Pulp Necrosis

Expression for Dental Pulp Necrosis

Search GEO for disease gene expression data for Dental Pulp Necrosis.

Pathways for Dental Pulp Necrosis

GO Terms for Dental Pulp Necrosis

Cellular components related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 8.92 AMBN AMELX AMELY DSPP

Biological processes related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.73 AMELX AMELY BMP2 DSPP
2 regulation of receptor activity GO:0010469 9.54 AMBN AMELX BMP2
3 osteoblast differentiation GO:0001649 9.46 AMELX BMP2
4 ossification GO:0001503 9.4 BMP2 DSPP
5 odontogenesis of dentin-containing tooth GO:0042475 9.33 AMBN AMELX BMP2
6 chondrocyte differentiation GO:0002062 9.32 AMELX BMP2
7 epithelial to mesenchymal transition GO:0001837 9.26 AMELX BMP2
8 tooth mineralization GO:0034505 8.96 AMELX AMELY
9 biomineral tissue development GO:0031214 8.92 AMBN AMELX AMELY DSPP

Molecular functions related to Dental Pulp Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 AMBN AMELX BMP2
2 structural constituent of tooth enamel GO:0030345 8.8 AMBN AMELX AMELY

Sources for Dental Pulp Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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