MCID: DNT006
MIFTS: 29

Dental Pulp Necrosis malady

Gastrointestinal diseases category

Summaries for Dental Pulp Necrosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Necrotic pulp is a finding in dentistry to describe dental pulp within a tooth which has become... more...

MalaCards: Dental Pulp Necrosis, also known as pulp necrosis, is related to root resorption and pulpitis. An important gene associated with Dental Pulp Necrosis is AMELY (amelogenin, Y-linked), and among its related pathways is E2F transcription factor network. The compounds myristic acid and stearic acid have been mentioned in the context of this disorder. Affiliated tissues include monocytes.

Aliases & Classifications for Dental Pulp Necrosis

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

dental pulp necrosis 8 10 60
pulp necrosis 8 44
necrosis of the pulp nos 8
necrosis of the pulp 8
necrotic pulp 8


External Ids:

Disease Ontology8 DOID:11623
MeSH34 D003790
ICD9CM27 522.1
ICD1025 K04.1

Related Diseases for Dental Pulp Necrosis

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17GeneCards, 18GeneDecks
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Diseases related to Dental Pulp Necrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1root resorption30.0AMELX
2pulpitis10.0
3sickle cell anemia10.0
4turner syndrome10.0AMELX, AMELY
5dental fluorosis10.0AMELX, AMELY
6amelogenesis imperfecta10.0AMBN, AMELY, AMELX

Graphical network of diseases related to Dental Pulp Necrosis:



Diseases related to dental pulp necrosis

Clinical Features for Dental Pulp Necrosis

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Drugs & Therapeutics for Dental Pulp Necrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Dental Pulp Necrosis

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Anatomical Context for Dental Pulp Necrosis

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32MalaCards
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MalaCards organs/tissues related to Dental Pulp Necrosis:

32
Monocytes

Animal Models for Dental Pulp Necrosis or affiliated genes

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Publications for Dental Pulp Necrosis

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50PubMed
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Articles related to Dental Pulp Necrosis:

idTitleAuthorsYear
1
Treatment of inflammatory external root resorption resulting from dental avulsion and pulp necrosis: clinical case report. (21903529)
2011
2
Protein kinase C synergistically stimulates tumor necrosis factor-alpha-induced secretion of urokinase-type plasminogen activator in human dental pulp cells. (18177545)
2008
3
Dental pulp necrosis as a rare complication of reduction malarplasty. (17667692)
2007
4
Neuropeptides stimulate production of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in human dental pulp cells. (15105969)
2004
5
Insertional inactivation of pac and rmlB genes reduces the release of tumor necrosis factor alpha, interleukin-6, and interleukin-8 induced by Streptococcus mutans in monocytic, dental pulp, and periodontal ligament cells. (12933861)
2003
6
Detection of tumor necrosis factor alpha in normal and inflamed human dental pulps. (12459320)
2002
7
Induction of dental pulp fibroblast matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression by interleukin-1alpha and tumor necrosis factor-alpha through a prostaglandin-dependent pathway. (11487149)
2001
8
Bradykinin and thrombin synergistically potentiate interleukin 1 and tumour necrosis factor induced prostanoid biosynthesis in human dental pulp fibroblasts. (8777276)
1996

Genetic Variations for Dental Pulp Necrosis

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Expression for genes affiliated with Dental Pulp Necrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dental Pulp Necrosis

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Pathways for genes affiliated with Dental Pulp Necrosis

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37NCBI BioSystems Database
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Pathways related to Dental Pulp Necrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CES2, CES3

Compounds for genes affiliated with Dental Pulp Necrosis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Dental Pulp Necrosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1myristic acid44 11 2411.6CES2, CES3
2stearic acid44 11 2411.5CES2, CES3
3palmitic acid28 11 2411.3CES2, CES3

GO Terms for genes affiliated with Dental Pulp Necrosis

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16Gene Ontology
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Cellular components related to Dental Pulp Necrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:0057889.6CES2, CES3
2proteinaceous extracellular matrixGO:0055788.9AMELX, AMELY, AMBN

Biological processes related to Dental Pulp Necrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1biomineral tissue developmentGO:0312149.5AMELX, AMELY
2odontogenesis of dentin-containing toothGO:0424759.5AMELX, AMBN

Molecular functions related to Dental Pulp Necrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.5AMELX, AMBN
2carboxylesterase activityGO:0040919.3CES2, CES3
3structural constituent of tooth enamelGO:0303459.1AMELX, AMELY, AMBN

Products for genes affiliated with Dental Pulp Necrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dental Pulp Necrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet