MCID: DNT007
MIFTS: 40

Dentin Sensitivity malady

Genetic diseases, Oral diseases, Rare diseases categories
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Summaries for Dentin Sensitivity

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MalaCards based summary: Dentin Sensitivity, also known as sensitive dentin, is related to periodontitis and gastroesophageal reflux disease. An important gene associated with Dentin Sensitivity is DSPP (dentin sialophosphoprotein), and among its related pathways are Hepatic ABC Transporters and Sodium channels and transporters inward current. The compounds allicin and camphor have been mentioned in the context of this disorder. Affiliated tissues include testes, and related mouse phenotypes are taste/olfaction and behavior/neurological.

Aliases & Classifications for Dentin Sensitivity

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 34MeSH, 57SNOMED-CT
See all sources

Dentin Sensitivity, Aliases & Descriptions:

Name: Dentin Sensitivity 8 10 44 62
 
Sensitive Dentin 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Oral diseases


External Ids:

Disease Ontology8 DOID:698
NCIt39 C50778
SNOMED-CT57 13468005
MeSH34 D003807

Related Diseases for Dentin Sensitivity

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Diseases in the Dentin Dysplasia, Type Ii family:

Dentin Dysplasia dentin sensitivity
Dentin Dysplasia, Type 1

Diseases related to Dentin Sensitivity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1periodontitis10.2
2gastroesophageal reflux disease10.2TRPV1, DSPP
3cervicitis10.1
4gingivitis10.1
5blindness10.1
6pulpitis10.0TRPV1, DSPP
7pain agnosia9.8TRPV1, TRPA1, TRPM8

Graphical network of diseases related to Dentin Sensitivity:



Diseases related to dentin sensitivity

Symptoms for Dentin Sensitivity

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Drugs & Therapeutics for Dentin Sensitivity

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Drug clinical trials:

Search ClinicalTrials for Dentin Sensitivity

Search NIH Clinical Center for Dentin Sensitivity

Genetic Tests for Dentin Sensitivity

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Anatomical Context for Dentin Sensitivity

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MalaCards organs/tissues related to Dentin Sensitivity:

32
Testes

Animal Models for Dentin Sensitivity or affiliated genes

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MGI Mouse Phenotypes related to Dentin Sensitivity:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2TRPA1, TRPV1, ENTPD2
2MP:00053868.1TRPA1, TRPM8, TRPV1, TRPM3, TRPV4, TRPV3
3MP:00107717.7TRPV4, CSN3, TRPV3, TRPA1, TRPM8, TRPV1
4MP:00036317.0TRPV1, TRPM3, TRPV4, TRPA1, ENTPD2, KCNK10

Publications for Dentin Sensitivity

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Articles related to Dentin Sensitivity:

(show all 26)
idTitleAuthorsYear
1
Randomized trial of the clinical efficacy of a potassium oxalate-containing mouthrinse in rapid relief of dentin sensitivity. (24282871)
2013
2
Biomimetic mineralization: long-term observations in patients with dentin sensitivity. (22305715)
2012
3
Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentin sensitivity. (21168271)
2011
4
Oxalic acid under adhesive restorations as a means to reduce dentin sensitivity: a four-month clinical trial. (21777095)
2011
5
Dentin sensitivity: an oral symptom that should not be neglected]. (19575978)
2009
6
Considerations for the development of over-the-counter dentifrices for the treatment and relief of dentin sensitivity. (19902641)
2009
7
Clinical evaluation of cervical dentin sensitivity (CDS) in patients attending general dental clinics (GDC) and periodontal specialty clinics (PSC). (11908469)
2002
8
Root-dentin sensitivity following non-surgical periodontal treatment. (10983603)
2000
9
The Dentin Disc surface: a plausible model for dentin physiology and dentin sensitivity evaluation. (9470509)
1997
10
Treatment of dentin sensitivity with stannous fluoride gel. Electron microscopic study and evaluation of dentin permeability]. (9567615)
1997
11
Dental pain evoked by hydrostatic pressures applied to exposed dentin in man: a test of the hydrodynamic theory of dentin sensitivity. (7996085)
1994
12
Theory of dentin sensitivity. (8534375)
1994
13
Relation of dentin sensitivity to histological changes in dog teeth with exposed and stimulated dentin. (1508867)
1992
14
Dentin permeability and dentin sensitivity. (1508886)
1992
15
Evaluation of tartar control dentifrices in in vitro models of dentin sensitivity. (1650304)
1991
16
An in vivo study of dentin sensitivity: the relation of dentin sensitivity and the patency of dentin tubules. (1753319)
1991
17
Mechanisms of dentin sensitivity. (2197121)
1990
18
The influence of frequent ingestion of acids in the diet on treatment for dentin sensitivity. (2285881)
1990
19
Double-blind evaluation of duration of dentin sensitivity reduction by fluoride iontophoresis. (2638286)
1989
20
The efficacy of a new dentifrice in treating dentin sensitivity: effects of sodium citrate and sodium fluoride as active ingredients. (2953887)
1987
21
Dentin permeability, dentin sensitivity, and treatment through tubule occlusion. (3465852)
1986
22
Dentin sensitivity: a review. (3860500)
1985
23
Clinical evaluation of the effectiveness of three dentifrices in relieving dentin sensitivity. (6596425)
1984
24
Dentin sensitivity, odontoblasts and nerves under desiccated or infected experimental cavities. A clinical, light microscopic and ultrastructural investigation. (6955990)
1982
25
Dentin sensitivity and aspiration of odontoblasts. (14014982)
1963
26
Sodium fluoride therapy for combating dentin sensitivity and gingival decay. (21008391)
1945

Variations for Dentin Sensitivity

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Expression for genes affiliated with Dentin Sensitivity

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Expression patterns in normal tissues for genes affiliated with Dentin Sensitivity

Search GEO for disease gene expression data for Dentin Sensitivity.

Pathways for genes affiliated with Dentin Sensitivity

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Pathways related to Dentin Sensitivity according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6KCNK10, KCNK4
2
Show member pathways
9.0TRPM3, TRPV1, TRPM8
38.8TRPM8, TRPA1, TRPV1, TRPV4
4
Show member pathways
8.8KCNK4, TRPM8, KCNK10
5
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
7.9TRPA1, TRPV2, TRPV3, TRPM8, TRPV1, TRPV4
6
Show member pathways
7.8TRPV2, TRPV4, TRPM3, TRPM8, TRPV3, TRPV1
77.5TRPM3, TRPV4, TRPV1, TRPM8, TRPA1, TRPV3
8
Show member pathways
7.5TRPV2, TRPM3, TRPV1, TRPM8, TRPA1, TRPV3
9
Show member pathways
7.5TRPV4, TRPM3, TRPV1, TRPM8, TRPA1, TRPV3

Compounds for genes affiliated with Dentin Sensitivity

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Compounds related to Dentin Sensitivity according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1allicin2810.2TRPV1, TRPA1
2camphor28 4411.2TRPV3, TRPV1
3resiniferatoxin44 2811.2TRPV1, TRPV4
4gd3+2810.1TRPV4, TRPM3
5thymol28 4411.0TRPV3, TRPA1, DSPP
6ruthenium4410.0TRPV1, TRPV4
7eugenol44 28 2412.0DSPP, TRPV3, TRPV1
8sodium azide449.9DSPP, ENTPD2
9riluzole44 28 1111.8KCNK4, KCNK10
10bl 1249619.8KCNK10, KCNK4
11tetraethylammonium chloride619.8KCNK4, KCNK10
12ys-035 hydrochloride619.8KCNK4, KCNK10
13dmp 543619.8KCNK10, KCNK4
14halothane44 50 28 1112.8KCNK10, DSPP
15icilin28 6110.7TRPA1, TRPM8
16bctc289.7TRPV1, TRPM8
17cesium chloride44 6110.7KCNK10, KCNK4
18nada289.7TRPV1, TRPM8
19diphenylboronic anhydride289.6TRPV1, TRPV3, TRPV2
20hydroxyapatite449.5DSPP, CSN3
21amiloride44 28 1111.5TRPV2, TRPV1
225-iodoresiniferatoxin61 2810.4TRPV3, TRPV1, TRPV4, TRPV2
23amg 9810619.4TRPV1, TRPV4, TRPV2, TRPV3
24hc 067047619.4TRPV1, TRPV4, TRPV2, TRPV3
25cannabidiol28 4410.3TRPV2, TRPM8
26potassium44 24 1111.3KCNK10, TRPV1, KCNK4
27arachidonic acid44 28 24 1112.3KCNK10, KCNK4, TRPV1, TRPV4
28menthol44 28 24 1112.2TRPA1, TRPM8, TRPV1, TRPV3
29delta9-tetrahydrocannabinol289.1TRPM8, TRPA1, TRPV2
302-apb28 6110.1TRPV1, TRPV3, TRPM8, TRPM3
31ruthenium red289.1TRPV4, TRPV2, TRPV3, TRPA1, TRPV1
32sodium44 2410.0TRPM8, TRPV4, TRPV1
33la3+288.8TRPM3, TRPM8, TRPV4, TRPV2
34capsazepine61 44 2810.5TRPV3, TRPV2, TRPV4, TRPV1, TRPM8
35capsaicin44 289.5TRPV1, TRPA1, TRPV4, TRPV2, TRPM8
36anandamide61 44 28 2411.5TRPV2, TRPV3, TRPM8, TRPV1, TRPV4
37calcium44 50 24 1110.0DSPP, TRPV4, TRPM3, TRPV2, ENTPD2, TRPV3

GO Terms for genes affiliated with Dentin Sensitivity

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Cellular components related to Dentin Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of membraneGO:0160217.1KCNK10, ENTPD2, TRPV3, TRPM8, TRPV1, TRPM3
2plasma membraneGO:0058865.9TRPV4, KCNK4, KCNK10, ENTPD2, TRPV2, TRPV3

Biological processes related to Dentin Sensitivity according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcium ion importGO:0902809.6TRPV3, TRPV2
2response to heatGO:0094089.5TRPV2, TRPV3
3response to coldGO:0094099.4TRPA1, TRPM8
4cellular calcium ion homeostasisGO:0068749.3TRPV4, TRPM8
5thermoceptionGO:0509559.2TRPA1, TRPV1, TRPM8
6transportGO:0068108.7TRPV2, KCNK10, TRPV1
7calcium ion transmembrane transportGO:0705887.7TRPM8, TRPV2, TRPV3, TRPA1, TRPV4, TRPV1
8ion transmembrane transportGO:0342207.7TRPV3, TRPM8, TRPV2, TRPA1, TRPV1, TRPM3
9transmembrane transportGO:0550857.7TRPM8, TRPA1, TRPV1, TRPM3, TRPV4, TRPV2

Molecular functions related to Dentin Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel activityGO:0052679.6KCNK10, KCNK4
2voltage-gated ion channel activityGO:0052449.3KCNK10, KCNK4
3cation channel activityGO:0052619.1TRPV2, TRPM3, TRPV4
4calcium channel activityGO:0052627.5TRPV1, TRPM8, TRPV3, TRPM3, TRPV4, TRPV2

Products for genes affiliated with Dentin Sensitivity

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Sources for Dentin Sensitivity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet