Aliases & Classifications for Dentin Sensitivity

Aliases & Descriptions for Dentin Sensitivity:

Name: Dentin Sensitivity 12 52 42 14 69
Sensitive Dentin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:698
MeSH 42 D003807
NCIt 47 C50778
SNOMED-CT 64 13468005
UMLS 69 C0011432

Summaries for Dentin Sensitivity

MalaCards based summary : Dentin Sensitivity, also known as sensitive dentin, is related to periodontitis and cervicitis, and has symptoms including toothache An important gene associated with Dentin Sensitivity is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and CREB Pathway. The drugs sodium fluoride and Glycerol have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotypes are behavior/neurological and integument

Related Diseases for Dentin Sensitivity

Diseases related to Dentin Sensitivity via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 periodontitis 9.8
2 cervicitis 9.6
3 gingivitis 9.6
4 childhood cerebral astrocytoma 7.8 ASIC3 CSN3 DSPP ENTPD2 GJA1 KCNK10

Symptoms & Phenotypes for Dentin Sensitivity

UMLS symptoms related to Dentin Sensitivity:


toothache

MGI Mouse Phenotypes related to Dentin Sensitivity:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ASIC3 GJA1 KCNK2 SIX1 TRPA1 TRPM3
2 integument MP:0010771 9.81 ASIC3 CSN3 GJA1 TRPA1 TRPM3 TRPM8
3 nervous system MP:0003631 9.73 TRPV1 TRPV4 ASIC3 ENTPD2 GJA1 KCNK10
4 hearing/vestibular/ear MP:0005377 9.65 TRPV4 ASIC3 GJA1 SIX1 TRPA1
5 taste/olfaction MP:0005394 8.92 ENTPD2 SIX1 TRPA1 TRPV1

Drugs & Therapeutics for Dentin Sensitivity

Drugs for Dentin Sensitivity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 4,Phase 2,Phase 3,Phase 1 7681-49-4
2
Glycerol Approved, Experimental Phase 4 56-81-5 753
3
Etodolac Approved, Investigational, Vet_approved Phase 4 41340-25-4 3308
4
Calcium carbonate Approved Phase 4 471-34-1
5 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
6 Anti-Infective Agents, Local Phase 4,Phase 2,Phase 3,Phase 1
7 Cariostatic Agents Phase 4,Phase 2,Phase 3,Phase 1
8 Fluorides Phase 4,Phase 2,Phase 3,Phase 1
9 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
10 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
11 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3
12 Calcium, Dietary Phase 4,Phase 2,Phase 3
13
Hydrogen peroxide Phase 4,Phase 3,Phase 1 7722-84-1 784
14 Listerine Phase 4,Phase 2,Phase 3,Phase 1
15 Fluorophosphate Phase 4,Phase 3,Phase 2
16
Tin Phase 4,Phase 3 7440-31-5
17 Tin Fluorides Phase 4,Phase 3
18 Analgesics Phase 4,Phase 3
19 Analgesics, Non-Narcotic Phase 4,Phase 3
20 Anti-Inflammatory Agents Phase 4,Phase 3
21 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
22 Antirheumatic Agents Phase 4,Phase 3
23 Cyclooxygenase 2 Inhibitors Phase 4
24 Cyclooxygenase Inhibitors Phase 4,Phase 3
25 Fluorides, Topical Phase 4
26 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
27 Antacids Phase 4
28 Anti-Ulcer Agents Phase 4
29 Gastrointestinal Agents Phase 4
30 arginine Nutraceutical Phase 4,Phase 3
31
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
32
Methamphetamine Approved, Illicit Phase 2, Phase 3 537-46-2 10836
33
Triclosan Approved Phase 3 3380-34-5 5564
34
Salicylic acid Approved, Vet_approved Phase 3 69-72-7 338
35
Piroxicam Approved, Investigational Phase 3 36322-90-4 5280452 54676228
36 Adrenergic Agents Phase 2, Phase 3
37 Autonomic Agents Phase 2, Phase 3
38 Central Nervous System Stimulants Phase 2, Phase 3
39 Dopamine Agents Phase 2, Phase 3
40 Dopamine Uptake Inhibitors Phase 2, Phase 3
41 Neurotransmitter Agents Phase 2, Phase 3
42 Neurotransmitter Uptake Inhibitors Phase 2, Phase 3
43 Anesthetics Phase 2, Phase 3
44 Antimetabolites Phase 3
45 Hypolipidemic Agents Phase 3
46 Lipid Regulating Agents Phase 3
47 Micronutrients Phase 3
48
Silicon Phase 3 7440-21-3 4082203
49 Trace Elements Phase 3
50
Betadex Phase 3 7585-39-9 320761

Interventional clinical trials:

(show top 50) (show all 129)
id Name Status NCT ID Phase
1 Efficacy of Two Oral Hygiene Regimens in the Reduction of Dentin Hypersensitivity After Periodontal Treatment Completed NCT02461030 Phase 4
2 Clinical Study of the Whitening Dentifrices on Tooth Color and Sensitivity Completed NCT02483013 Phase 4
3 Nano-hydroxyapatite With Potassium Nitrate in the Therapy of the Dental Sensitivity Completed NCT02895321 Phase 4
4 The Effect of Desensitizing Agents in In-home or In-office Dental Bleaching Completed NCT02316080 Phase 4
5 Study to Investigate the Efficacy of an Occluding Dentifrice in Providing Relief From Dentine Hypersensitivity Completed NCT02773758 Phase 4
6 Longevity and Effectiveness of Bleaching in Healthy and Smokers Patients Completed NCT02017873 Phase 4
7 Etodolac and Post-bleaching Sensitivity Completed NCT02881619 Phase 4
8 Short Term Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity Completed NCT02731833 Phase 4
9 To Investigate the Efficacy of an Occluding Dentifrice in Dentinal Hypersensitivity (DH) Completed NCT02923895 Phase 4
10 Dose Response of a Tubule Occlusion Agent Completed NCT01075256 Phase 4
11 An Evaluation of the Efficacy of Oral-B New Product Sensi-Stop on Dentinal Hypersensitivity Completed NCT02476032 Phase 4
12 Clinical Effectiveness of In-office Bleaching Activated With a LED/Laser Device Completed NCT01231243 Phase 4
13 Efficacy of a Whitening Dentifrice on Tooth Discoloration Completed NCT02741427 Phase 4
14 Effectiveness of Nanohydroxyapetite Paste on Reducing Dentin Hypersensitivity Recruiting NCT02936830 Phase 4
15 Combined Bleaching Technique: Efficacy and Tooth Sensitivity Active, not recruiting NCT03089216 Phase 4
16 The Efficacy of Cyanoacrylate Adhesive (PeriAcryl®90 HV) in Periodontal Wound Healing Not yet recruiting NCT02826109 Phase 4
17 Evaluation of Dentin Hypersensitivity Using Glass Ionomer Cements Unknown status NCT02378129 Phase 2, Phase 3
18 Dentin Treatments for Restorations of Cervical Lesions Non-Carious Unknown status NCT02434601 Phase 2, Phase 3
19 Effectiveness of a Homecare Dentin Hypersensitivity Gel Completed NCT02128633 Phase 2, Phase 3
20 Cyanoacrylate and Laser and Dentin Sensitivity Completed NCT01111474 Phase 3
21 IN-OFFICE TOOTH BLEACHING WITH 37% CARBAMIDE PEROXIDE Completed NCT02935114 Phase 3
22 Investigating the Efficacy of a Dentifrice in Providing Long Term Relief From Dentinal Hypersensitivity Completed NCT01827670 Phase 3
23 Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity Completed NCT02832375 Phase 3
24 The Efficacy of a Toothpaste to Reduce Sensitivity Completed NCT00763269 Phase 3
25 The Efficacy of a Dentifrice in Providing Relief From Dentinal Hypersensitivity Completed NCT01724008 Phase 3
26 The Efficacy of a Dentifrice in Providing Relief From Immediate and Short Term Relief From Dentinal Hypersensitivity Completed NCT03072719 Phase 3
27 The Efficacy of a Dentifrice in Providing Relief From the Pain of Dentinal Hypersensitivity Completed NCT01592864 Phase 3
28 Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity Completed NCT01592851 Phase 3
29 Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
30 Noncarious Cervical Lesion Treatment Outcomes Completed NCT00867997 Phase 3
31 Outcome Evaluation of Ceramic Crowns Using Two Different Dental Cements Completed NCT00591942 Phase 3
32 Effectiveness of Arginin and Potassium Nitrate Dentifrices in Dentin Hypersensitivity Therapy Recruiting NCT02829879 Phase 3
33 Potassium Oxalate and Potassium Nitrate and Post-bleaching Sensitivity Recruiting NCT02941653 Phase 3
34 Comparison of Different Desensitizers in Reducing Dentinal Hypersensitivity Recruiting NCT03177109 Phase 3
35 Piroxicam-beta-Cyclodextrin on Tooth Sensitivity Caused by In-office Bleaching Active, not recruiting NCT03153657 Phase 3
36 Comparison Between Biodentine and Calcium Hydroxide in the Indirect Pulp Treatment on Primary Teeth Active, not recruiting NCT02799927 Phase 2, Phase 3
37 Clinical Evaluation of Esthetic Restorations Placed in Primary Molars With Composite Resin Enriched With Insoluble Anti Bacterial Nano Particles Unknown status NCT00389714 Phase 2
38 Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-Containing Toothpastes and Cream Completed NCT02918617 Phase 2
39 Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity Completed NCT01115452 Phase 2
40 Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity Completed NCT02226562 Phase 2
41 Exploratory Study to Evaluate an Occlusion Based Dentifrice in Relief of Dentinal Hypersensitivity Completed NCT01691560 Phase 2
42 Exploratory Study to Evaluate the Efficacy of an Occlusion Based Dentifrice in Relief of Dentinal Hypersensitivity Completed NCT01831817 Phase 2
43 Clinical Performance of 3-Unit FPDs Completed NCT00223431 Phase 2
44 Clinical Trial of the Effect of Different Categories of Adhesive System Active, not recruiting NCT02751970 Phase 2
45 Evaluation of Biodentine Versus Glass Ionomer Cement in Treatment of Very Deep Carious Lesions Not yet recruiting NCT02868918 Phase 2
46 Evaluation of the Effect of Fluoride and Laser Application on the Prevention of Sensitivity in Bleached Teeth Completed NCT03044171 Phase 1
47 Pharmacokinetics of Diammine Silver Fluoride Completed NCT01664871 Phase 1
48 The Effects of Potassium Nitrate in Reducing Dentinal Hypersensitivity Completed NCT01587950 Phase 1
49 Effects of DIammine SIlver Fluoride on Tooth Sensitivity Unknown status NCT01063530
50 Tooth Bleaching for Young Patients Using a Hydrogen Peroxide-based Gel Unknown status NCT02414464

Search NIH Clinical Center for Dentin Sensitivity

Cochrane evidence based reviews: dentin sensitivity

Genetic Tests for Dentin Sensitivity

Anatomical Context for Dentin Sensitivity

MalaCards organs/tissues related to Dentin Sensitivity:

39
Testes

Publications for Dentin Sensitivity

Articles related to Dentin Sensitivity:

(show all 26)
id Title Authors Year
1
Randomized trial of the clinical efficacy of a potassium oxalate-containing mouthrinse in rapid relief of dentin sensitivity. ( 24282871 )
2013
2
Biomimetic mineralization: long-term observations in patients with dentin sensitivity. ( 22305715 )
2012
3
Oxalic acid under adhesive restorations as a means to reduce dentin sensitivity: a four-month clinical trial. ( 21777095 )
2011
4
Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentin sensitivity. ( 21168271 )
2011
5
[Dentin sensitivity: an oral symptom that should not be neglected]. ( 19575978 )
2009
6
Considerations for the development of over-the-counter dentifrices for the treatment and relief of dentin sensitivity. ( 19902641 )
2009
7
Clinical evaluation of cervical dentin sensitivity (CDS) in patients attending general dental clinics (GDC) and periodontal specialty clinics (PSC). ( 11908469 )
2002
8
Root-dentin sensitivity following non-surgical periodontal treatment. ( 10983603 )
2000
9
[Treatment of dentin sensitivity with stannous fluoride gel. Electron microscopic study and evaluation of dentin permeability]. ( 9567615 )
1997
10
The Dentin Disc surface: a plausible model for dentin physiology and dentin sensitivity evaluation. ( 9470509 )
1997
11
Theory of dentin sensitivity. ( 8534375 )
1994
12
Dental pain evoked by hydrostatic pressures applied to exposed dentin in man: a test of the hydrodynamic theory of dentin sensitivity. ( 7996085 )
1994
13
Relation of dentin sensitivity to histological changes in dog teeth with exposed and stimulated dentin. ( 1508867 )
1992
14
Dentin permeability and dentin sensitivity. ( 1508886 )
1992
15
Evaluation of tartar control dentifrices in in vitro models of dentin sensitivity. ( 1650304 )
1991
16
An in vivo study of dentin sensitivity: the relation of dentin sensitivity and the patency of dentin tubules. ( 1753319 )
1991
17
Mechanisms of dentin sensitivity. ( 2197121 )
1990
18
The influence of frequent ingestion of acids in the diet on treatment for dentin sensitivity. ( 2285881 )
1990
19
Double-blind evaluation of duration of dentin sensitivity reduction by fluoride iontophoresis. ( 2638286 )
1989
20
The efficacy of a new dentifrice in treating dentin sensitivity: effects of sodium citrate and sodium fluoride as active ingredients. ( 2953887 )
1987
21
Dentin permeability, dentin sensitivity, and treatment through tubule occlusion. ( 3465852 )
1986
22
Dentin sensitivity: a review. ( 3860500 )
1985
23
Clinical evaluation of the effectiveness of three dentifrices in relieving dentin sensitivity. ( 6596425 )
1984
24
Dentin sensitivity, odontoblasts and nerves under desiccated or infected experimental cavities. A clinical, light microscopic and ultrastructural investigation. ( 6955990 )
1982
25
Dentin sensitivity and aspiration of odontoblasts. ( 14014982 )
1963
26
Sodium fluoride therapy for combating dentin sensitivity and gingival decay. ( 21008391 )
1945

Variations for Dentin Sensitivity

Expression for Dentin Sensitivity

Search GEO for disease gene expression data for Dentin Sensitivity.

Pathways for Dentin Sensitivity

Pathways related to Dentin Sensitivity according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 ASIC3 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2
2
Show member pathways
12.96 TRPM3 TRPM8 TRPV1 TRPV2 TRPV3 TRPV4
3
Show member pathways
12.38 ASIC3 TRPA1 TRPM8 TRPV1 TRPV2 TRPV3
4
Show member pathways
12.05 ASIC3 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2
5
Show member pathways
11.71 KCNK10 KCNK2 KCNK4
6
Show member pathways
11.59 KCNK10 KCNK2 KCNK4
7 10.57 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2 TRPV3

GO Terms for Dentin Sensitivity

Cellular components related to Dentin Sensitivity according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.97 ASIC3 ENTPD2 GJA1 KCNK10 KCNK2 KCNK4
2 plasma membrane GO:0005886 9.77 ASIC3 ENTPD2 GJA1 KCNK10 KCNK2 KCNK4
3 integral component of plasma membrane GO:0005887 9.28 ASIC3 GJA1 KCNK2 KCNK4 TRPA1 TRPV1

Biological processes related to Dentin Sensitivity according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.97 CSN3 GJA1 TRPA1 TRPM3 TRPM8 TRPV1
2 ion transmembrane transport GO:0034220 9.86 ASIC3 GJA1 TRPA1 TRPM3 TRPM8 TRPV1
3 potassium ion transport GO:0006813 9.82 KCNK10 KCNK2 KCNK4
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.82 GJA1 TRPV1 TRPV4
5 potassium ion transmembrane transport GO:0071805 9.81 KCNK10 KCNK2 KCNK4
6 response to heat GO:0009408 9.8 ASIC3 TRPV1 TRPV2 TRPV3
7 cation transport GO:0006812 9.77 ASIC3 TRPM3 TRPM8
8 protein homotetramerization GO:0051289 9.76 TRPA1 TRPM8 TRPV1
9 response to mechanical stimulus GO:0009612 9.73 ASIC3 KCNK2 TRPV4
10 memory GO:0007613 9.72 KCNK10 KCNK2 KCNK4
11 sensory perception of pain GO:0019233 9.71 KCNK4 TRPA1 TRPV1
12 calcium ion transport GO:0006816 9.7 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2 TRPV3
13 response to temperature stimulus GO:0009266 9.65 TRPM8 TRPV2 TRPV3
14 response to pain GO:0048265 9.63 TRPA1 TRPV1
15 positive regulation of calcium ion import GO:0090280 9.63 TRPV2 TRPV3
16 sensory perception of temperature stimulus GO:0050951 9.63 KCNK4 TRPM3 TRPM8
17 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.62 ASIC3 TRPV1
18 sensory perception GO:0007600 9.62 ASIC3 TRPV2
19 response to pH GO:0009268 9.61 GJA1 TRPV1
20 negative regulation of DNA biosynthetic process GO:2000279 9.61 GJA1 KCNK2
21 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.61 ASIC3 TRPA1 TRPV1
22 negative regulation of cardiac muscle cell proliferation GO:0060044 9.6 GJA1 KCNK2
23 diet induced thermogenesis GO:0002024 9.58 TRPV1 TRPV4
24 thermoception GO:0050955 9.58 TRPA1 TRPM8 TRPV1
25 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.57 ASIC3 TRPA1
26 cellular response to temperature stimulus GO:0071502 9.52 KCNK4 TRPV1
27 detection of temperature stimulus GO:0016048 9.51 TRPM3 TRPM8
28 calcium ion transmembrane transport GO:0070588 9.5 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2 TRPV3
29 ion transport GO:0006811 9.36 ASIC3 KCNK10 KCNK2 KCNK4 TRPA1 TRPM3
30 transport GO:0006810 10.15 ASIC3 GJA1 KCNK10 KCNK2 KCNK4 TRPA1

Molecular functions related to Dentin Sensitivity according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.58 TRPV1 TRPV2 TRPV4
2 calcium channel activity GO:0005262 9.5 TRPA1 TRPM3 TRPM8 TRPV1 TRPV2 TRPV3
3 potassium channel activity GO:0005267 9.43 KCNK10 KCNK2 KCNK4
4 ion transmembrane transporter activity GO:0015075 9.37 GJA1 TRPV2
5 calcium-release channel activity GO:0015278 9.32 TRPA1 TRPV1
6 temperature-gated cation channel activity GO:0097604 9.16 KCNK4 TRPA1
7 cation channel activity GO:0005261 9.1 ASIC3 TRPM3 TRPV1 TRPV2 TRPV3 TRPV4

Sources for Dentin Sensitivity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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