Dentin Sensitivity malady

MalaCards: Dentin Sensitivity, also known as sensitive dentin (disorder), is related to somatoform disorder and pulpitis. An important gene associated with Dentin Sensitivity is DSPP (dentin sialophosphoprotein), and among its related pathways are Sodium channels and transporters- inward current and Tandem pore domain potassium channels. The compounds icilin and eugenol have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and integument.

Aliases & Descriptions:

dentin sensitivity 6 8 32 43 sensitive dentin (disorder) 6

sensitive dentin 6

Diseases related to dentin sensitivity by text searches and GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	somatoform disorder	12.6	TRPV1, TRPA1
2	pulpitis	12.5	TRPV1, DSPP
3	insensitivity to pain	12.2	TRPV2, TRPV1, TRPM8
4	dermatitis	12.0	TRPV1, TRPV3, CSN3, DSPP
5	diabetic neuropathy	11.3	TRPM8, TRPV4, TRPV3, TRPV1
6	neuropathy	10.9	TRPA1, TRPM8, TRPV3, TRPV4, TRPV1
7	neuronitis	9.0	DSPP, KCNK4, ARHGAP32, TRPV3, TRPV1, TRPV2
8	periodontitis	7.2
9	cervicitis	6.2

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to dentin sensitivity:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	7.2	TRPA1, TRPV4, TRPV3, TRPV1, TRPM3, KCNK2
2	integument phenotype	MP:0010771	7.2	CSN3, TRPM8, TRPA1, TRPV4, TRPV3, TRPV1
3	nervous system phenotype	MP:0003631	6.2	KCNK2, TRPM8, TRPA1, TRPV4, TRPV1, TRPM3

Articles related to dentin sensitivity:

(show all 11)

id	Title	Authors	Year	Affiliating Genes
1	Dentin sensitivity: an oral symptom that should not be neglected (19575978)	Gao X.J.... Zeng Y.	2009	DSPP
2	Considerations for the development of over-the-counte r dentifrices for the treatment and relief of dentin sensitivity. (19902641)	Mason S.... Layer T.	2009	DSPP
3	Clinical evaluation of cervical dentin sensitivity (C DS) in patients attending general dental clinics (GDC) and periodontal specialt y clinics (PSC). (11908469)	Taani S.D.... Awartani F.	2002	DSPP
4	Root-dentin sensitivity following non-surgical periodontal treatment. (10983603)	Tammaro S.... Bergenholtz G.	2000	DSPP
5	The Dentin Disc surface: a plausible model for dentin physiology and dentin sensitivity evaluation. (9470509)	Gillam D.G.... Newman H.N.	1997	DSPP
6	Treatment of dentin sensitivity with stannous fluori de gel. Electron microscopic study and evaluation of dentin permeability (9567615)	Lucchese A.... Dolci F.	1997	DSPP
7	Theory of dentin sensitivity. (8534375)	Pashley D.H.	1994	DSPP
8	Evaluation of tartar control dentifrices in in vitro models of dentin sensitivity. (1650304)	Mason S.... Gaffar A.	1991	DSPP
9	An in vivo study of dentin sensitivity: the relation of dentin sensitivity and the patency of dentin tubules. (1753319)	Cuenin M.F.... Van Dyke T.E.	1991	DSPP
10	The influence of frequent ingestion of acids in the d iet on treatment for dentin sensitivity. (2285881)	Clark D.C.... Grisdale J.C.	1990	DSPP
11	Mechanisms of dentin sensitivity. (2197121)	Pashley D.H.	1990	DSPP

Genes related to dentin sensitivity according to GeneCards:

(show all 15)

id	Symbol	Description	Score	GeneCards Section Context
1	DSPP	dentin sialophosphoprotein	11.0	Publications
2	KCNK4	potassium channel, subfamily K, member 4	11.0
3	TRPA1	transient receptor potential cation channel, subfamily A, member 1	11.0
4	CSN3	casein kappa	11.0
5	ENTPD2	ectonucleoside triphosphate diphosphohydrolase 2	11.0	Disorders
6	TRPV2	transient receptor potential cation channel, subfamily V, member 2	11.0
7	NT5M	5',3'-nucleotidase, mitochondrial	11.0	Disorders
8	TRPV3	transient receptor potential cation channel, subfamily V, member 3	11.0
9	TRPV1	transient receptor potential cation channel, subfamily V, member 1	11.0
10	TRPM8	transient receptor potential cation channel, subfamily M, member 8	11.0
11	ARHGAP32	Rho GTPase activating protein 32	11.0
12	KCNK2	potassium channel, subfamily K, member 2	11.0
13	KCNK10	potassium channel, subfamily K, member 10	11.0	Disorders
14	TRPV4	transient receptor potential cation channel, subfamily V, member 4	11.0
15	TRPM3	transient receptor potential cation channel, subfamily M, member 3	11.0	Disorders

Pathways related to dentin sensitivity according to GeneDecks:

(show all 15)

id	Pathway	Score	Top Affiliating Genes
1	Sodium channels and transporters- inward current10	9.4	TRPM8, TRPV1, TRPM3
2	Tandem pore domain potassium channels38	9.4	KCNK10, KCNK4, KCNK2
3	MODY (Maturity-Onset Diabetes of Young)36	9.3	KCNK2, KCNK4, KCNK10
4	Hepatic ABC Transporters36	9.3	KCNK10, KCNK4, KCNK2
5	Bitter Taste Signaling36	9.3	KCNK2, KCNK4, KCNK10
6	Sweet Taste Signaling36	9.2	KCNK10, KCNK4, KCNK2
7	Aldosterone Signaling in Epithelial Cells36	9.2	KCNK2, KCNK4, KCNK10
8	Cholera Infection36	9.2	KCNK10, KCNK4, KCNK2
9	Neuropathic Pain-Signaling in Dorsal Horn Neurons36	9.1	KCNK2, KCNK4, KCNK10
10	Sperm Motility36	9.1	KCNK2, KCNK4, KCNK10
11	Melatonin Signaling36	9.0	KCNK10, KCNK4, KCNK2
12	Potassium transporters- outward current10	9.0	KCNK2, KCNK4, KCNK10, TRPM8
13	Calcium channels10	8.9	TRPV1, TRPV4, TRPA1, TRPM8
14	Cellular Effects of Sildenafil36	8.8	KCNK2, KCNK4, KCNK10
15	Intracellular Calcium Signaling36	8.0	TRPM8, TRPV4, TRPV3, TRPV2, TRPV1, TRPM3

Compounds related to dentin sensitivity according to GeneDecks:

(show all 18)

id	Compound	Score	Top Affiliating Genes
1	icilin42	10.0	TRPA1, TRPM8
2	eugenol32 18	10.9	TRPV1, DSPP
3	sodium azide32	9.9	ENTPD2, DSPP
4	2-apb42	9.8	TRPM8, TRPA1
5	ppahv42 32	10.7	TRPV1, TRPV2, TRPV3
6	olvanil32 42	10.7	TRPV3, TRPV2, TRPV1
7	menthol32 9 18 9	12.4	TRPV1, TRPV3, TRPA1, TRPM8
8	ys-035 hydrochloride42	9.3	KCNK10, KCNK4, KCNK2
9	dmp 54342	9.3	KCNK10, KCNK4, KCNK2
10	6-iodonordihydrocapsaicin42	9.3	TRPV2, TRPV3, TRPV4
11	ruthenium32	9.3	TRPV1, TRPV4
12	halothane32 9 9	11.2	KCNK2, KCNK10, DSPP
13	resiniferatoxin32 42	9.9	TRPV4, TRPV3, TRPV2, TRPV1
14	capsazepine32 42	9.9	TRPV1, TRPV2, TRPV3, TRPV4
15	capsaicin32	8.6	TRPM8, TRPA1, TRPV4, TRPV2, TRPV1
16	potassium32 9 18 9	11.4	KCNK2, KCNK4, KCNK10, TRPV1
17	arachidonic acid32 9 18 9	11.0	TRPV4, TRPV1, KCNK10, KCNK4, KCNK2
18	calcium32 9 18 9	9.7	CSN3, DSPP, TRPM8, TRPV4, TRPV3, TRPV2

Biological processes related to dentin sensitivity according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	response to cold	GO:009409	9.8	TRPA1, TRPM8
2	response to temperature stimulus	GO:009266	9.5	TRPV2, TRPV3
3	thermoception	GO:050955	9.3	TRPV1, TRPA1, TRPM8

Molecular functions related to dentin sensitivity according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	potassium channel activity	GO:005267	9.6	KCNK4, KCNK10
2	voltage-gated ion channel activity	GO:005244	9.3	KCNK4, KCNK10
3	cation channel activity	GO:005261	8.7	TRPV4, TRPV2, TRPM3
4	calcium channel activity	GO:005262	7.4	TRPM3, TRPV1, TRPV2, TRPV3, TRPV4, TRPA1