MCID: DNT007
MIFTS: 34

Dentin Sensitivity malady

Summaries for Dentin Sensitivity

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32MalaCards
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MalaCards: Dentin Sensitivity, also known as sensitive dentin, is related to periodontitis and cervicitis. An important gene associated with Dentin Sensitivity is DSPP (dentin sialophosphoprotein), and among its related pathways are Sodium channels and transporters: inward current and Calcium channels. The compounds allicin and camphor have been mentioned in the context of this disorder. Affiliated tissues include testes, and related mouse phenotypes are behavior/neurological and integument.

Aliases & Classifications for Dentin Sensitivity

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

dentin sensitivity 8 10 44 60
sensitive dentin 8


External Ids:

Disease Ontology8 DOID:698
NCIt39 C50778
SNOMED-CT56 13468005
MeSH34 D003807

Related Diseases for Dentin Sensitivity

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17GeneCards, 18GeneDecks
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Diseases in the Dentin Dysplasia family:

dentin sensitivity Dentin Dysplasia, Type 1
Dentin Dysplasia, Type Ii

Diseases related to Dentin Sensitivity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1periodontitis10.2
2cervicitis10.0
3gingivitis10.0
4cholera10.0ENTPD2
5migraine10.0TRPV1
6neuropathy10.0TRPV4, TRPV1
7pulpitis10.0TRPV1, DSPP
8pain agnosia10.0TRPM8, TRPA1, TRPV1

Graphical network of diseases related to Dentin Sensitivity:



Diseases related to dentin sensitivity

Clinical Features for Dentin Sensitivity

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Drugs & Therapeutics for Dentin Sensitivity

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dentin Sensitivity

Drug clinical trials:

Search ClinicalTrials for Dentin Sensitivity

Search NIH Clinical Center for Dentin Sensitivity

Search CenterWatch for Dentin Sensitivity

Genetic Tests for Dentin Sensitivity

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Anatomical Context for Dentin Sensitivity

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32MalaCards
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MalaCards organs/tissues related to Dentin Sensitivity:

32
Testes

Animal Models for Dentin Sensitivity or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dentin Sensitivity:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.0KCNK2, TRPA1, TRPV1, TRPV3, TRPV4, TRPM8
2MP:00107717.9TRPM3, TRPM8, TRPV4, TRPV3, TRPV1, TRPA1
3MP:00036316.5TRPA1, KCNK2, ARHGAP32, KCNK4, TRPV1, TRPV4

Publications for Dentin Sensitivity

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50PubMed
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Articles related to Dentin Sensitivity:

(show all 37)
idTitleAuthorsYear
1
Randomized trial of the clinical efficacy of a potassium oxalate-containing mouthrinse in rapid relief of dentin sensitivity. (24282871)
2013
2
Biomimetic mineralization: long-term observations in patients with dentin sensitivity. (22305715)
2012
3
Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentin sensitivity. (21168271)
2011
4
Oxalic acid under adhesive restorations as a means to reduce dentin sensitivity: a four-month clinical trial. (21777095)
2011
5
A breakthrough therapy for dentin hypersensitivity: how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth. (19489189)
2009
6
Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy. (19489188)
2009
7
Polarization-sensitive optical coherence tomography for the nondestructive assessment of the remineralization of dentin. (19725714)
2009
8
Dentin sensitivity: an oral symptom that should not be neglected]. (19575978)
2009
9
Nondestructive assessment of dentin demineralization using polarization-sensitive optical coherence tomography after exposure to fluoride and laser irradiation. (19283826)
2009
10
Dentin hypersensitivity: from diagnosis to a breakthrough therapy for everyday sensitivity relief. (19489186)
2009
11
Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study on Canadian adults. (19489187)
2009
12
Considerations for the development of over-the-counter dentifrices for the treatment and relief of dentin sensitivity. (19902641)
2009
13
The effect of anti-sensitivity dentifrices on brushing abrasion of eroded dentin in vitro. (19278085)
2008
14
Clinical effectiveness of dentin sealer in treating dental root sensitivity following periodontal surgery. (16607061)
2006
15
Clinical evaluation of two adhesive composite cements for the suppression of dentinal cold sensitivity. (12239480)
2002
16
Clinical evaluation of cervical dentin sensitivity (CDS) in patients attending general dental clinics (GDC) and periodontal specialty clinics (PSC). (11908469)
2002
17
The sensitivity and specificity of clinical assessment compared with bitewing radiography for detection of occlusal dentin caries. (11447949)
2001
18
Root-dentin sensitivity following non-surgical periodontal treatment. (10983603)
2000
19
Technique sensitivity of dentin bonding: effect of application mistakes on bond strength and marginal adaptation. (11203838)
2000
20
The Dentin Disc surface: a plausible model for dentin physiology and dentin sensitivity evaluation. (9470509)
1997
21
Treatment of dentin sensitivity with stannous fluoride gel. Electron microscopic study and evaluation of dentin permeability]. (9567615)
1997
22
Dental pain evoked by hydrostatic pressures applied to exposed dentin in man: a test of the hydrodynamic theory of dentin sensitivity. (7996085)
1994
23
Theory of dentin sensitivity. (8534375)
1994
24
Relation of dentin sensitivity to histological changes in dog teeth with exposed and stimulated dentin. (1508867)
1992
25
Dentin permeability and dentin sensitivity. (1508886)
1992
26
Evaluation of tartar control dentifrices in in vitro models of dentin sensitivity. (1650304)
1991
27
An in vivo study of dentin sensitivity: the relation of dentin sensitivity and the patency of dentin tubules. (1753319)
1991
28
Mechanisms of dentin sensitivity. (2197121)
1990
29
The influence of frequent ingestion of acids in the diet on treatment for dentin sensitivity. (2285881)
1990
30
Double-blind evaluation of duration of dentin sensitivity reduction by fluoride iontophoresis. (2638286)
1989
31
The efficacy of a new dentifrice in treating dentin sensitivity: effects of sodium citrate and sodium fluoride as active ingredients. (2953887)
1987
32
Dentin permeability, dentin sensitivity, and treatment through tubule occlusion. (3465852)
1986
33
Dentin sensitivity: a review. (3860500)
1985
34
Clinical evaluation of the effectiveness of three dentifrices in relieving dentin sensitivity. (6596425)
1984
35
Dentin sensitivity, odontoblasts and nerves under desiccated or infected experimental cavities. A clinical, light microscopic and ultrastructural investigation. (6955990)
1982
36
Dentin sensitivity and aspiration of odontoblasts. (14014982)
1963
37
Sodium fluoride therapy for combating dentin sensitivity and gingival decay. (21008391)
1945

Genetic Variations for Dentin Sensitivity

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Expression for genes affiliated with Dentin Sensitivity

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dentin Sensitivity

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Pathways for genes affiliated with Dentin Sensitivity

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12EMD Millipore, 51QIAGEN, 53Reactome
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Compounds for genes affiliated with Dentin Sensitivity

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28IUPHAR, 44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB
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Compounds related to Dentin Sensitivity according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1allicin2810.2TRPA1, TRPV1
2camphor44 2811.1TRPV3, TRPV1
3thymol44 2811.1TRPV3, TRPA1, DSPP
4resiniferatoxin44 2811.1TRPV1, TRPV4
5eugenol44 28 2412.1DSPP, TRPV1, TRPV3
6bctc2810.0TRPV1, TRPM8
7ruthenium4410.0TRPV4, TRPV1
8icilin28 5911.0TRPA1, TRPM8
9nada289.9TRPV1, TRPM8
10gd3+289.9TRPM3, TRPV4
11diphenylboronic anhydride289.8TRPV2, TRPV3, TRPV1
125-iodoresiniferatoxin59 2810.6TRPV1, TRPV3, TRPV4, TRPV2
13amg 9810599.6TRPV2, TRPV4, TRPV3, TRPV1
14hc 067047599.6TRPV1, TRPV3, TRPV4, TRPV2
15sodium azide449.6ENTPD2, DSPP
16δ9-tetrahydrocannabinol289.6TRPV2, TRPM8, TRPA1
17cannabidiol28 4410.6TRPM8, TRPV2
18menthol44 28 11 2412.6TRPA1, TRPV1, TRPV3, TRPM8
192-apb28 5910.5TRPV1, TRPV3, TRPM8, TRPM3
20ruthenium red289.4TRPA1, TRPV1, TRPV3, TRPV4, TRPV2
21riluzole44 28 1111.3KCNK4, KCNK10, KCNK2
22dmp 543599.3KCNK4, KCNK10, KCNK2
23ys-035 hydrochloride599.3KCNK4, KCNK10, KCNK2
24bl 1249599.3KCNK4, KCNK10, KCNK2
25la3+289.3TRPV2, TRPM3, TRPM8, TRPV4
26tetraethylammonium chloride599.3KCNK4, KCNK10, KCNK2
27cesium chloride44 5910.3KCNK4, KCNK10, KCNK2
28halothane44 28 1111.3DSPP, KCNK2, KCNK10
29capsaicin44 2810.1TRPA1, TRPV1, TRPV4, TRPM8, TRPV2
30capsazepine44 59 2811.1TRPV2, TRPV1, TRPV3, TRPV4, TRPM8
31anandamide44 28 59 2412.1TRPV1, TRPV3, TRPV4, TRPM8, TRPV2
32arachidonic acid44 28 11 2411.7KCNK4, KCNK10, KCNK2, TRPV1, TRPV4
33potassium44 11 2410.7KCNK4, KCNK10, KCNK2, TRPV1
34calcium44 49 11 2410.0CSN3, ARHGAP32, DSPP, TRPV1, TRPV3, TRPV4

GO Terms for genes affiliated with Dentin Sensitivity

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16Gene Ontology
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Cellular components related to Dentin Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to membraneGO:0160217.7ENTPD2, TRPM3, TRPM8, TRPV4, TRPV3, TRPV1

Biological processes related to Dentin Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to coldGO:0094099.7TRPM8, TRPA1
2response to temperature stimulusGO:0092669.4TRPV2, TRPV3
3thermoceptionGO:0509559.4TRPM8, TRPV1, TRPA1

Molecular functions related to Dentin Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel activityGO:0052679.6KCNK10, KCNK4
2cation channel activityGO:0052619.4TRPV4, TRPM3, TRPV2
3voltage-gated ion channel activityGO:0052449.3KCNK10, KCNK4
4calcium channel activityGO:0052628.2TRPM8, TRPV4, TRPV1, TRPM3, TRPV2, TRPA1

Products for genes affiliated with Dentin Sensitivity

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  • Antibodies
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Sources for Dentin Sensitivity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet