MCID: DNT007
MIFTS: 40

Dentin Sensitivity malady

Genetic diseases, Oral diseases, Rare diseases categories

Summaries for Dentin Sensitivity

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34MalaCards
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MalaCards: Dentin Sensitivity, also known as sensitive dentin, is related to periodontitis and cervicitis. An important gene associated with Dentin Sensitivity is DSPP (dentin sialophosphoprotein), and among its related pathways are Hepatic ABC Transporters and Sodium channels and transporters inward current. The compounds allicin and camphor have been mentioned in the context of this disorder. Affiliated tissues include testes, and related mouse phenotypes are taste/olfaction and behavior/neurological.

Aliases & Classifications for Dentin Sensitivity

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Oral diseases


Aliases & Descriptions:

dentin sensitivity 9 11 46 63
sensitive dentin 9


External Ids:

Disease Ontology9 DOID:698
MeSH36 D003807
SNOMED-CT59 13468005
NCIt41 C50778

Related Diseases for Dentin Sensitivity

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Dentin Dysplasia, Type Ii family:

dentin sensitivity Dentin Dysplasia
Dentin Dysplasia, Type 1

Diseases related to Dentin Sensitivity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1periodontitis10.2
2cervicitis10.1
3gingivitis10.1
4blindness10.1
5gastroesophageal reflux disease10.0TRPV1, DSPP
6pulpitis10.0TRPV1, DSPP
7pain agnosia10.0TRPA1, TRPM8, TRPV1

Graphical network of diseases related to Dentin Sensitivity:



Diseases related to dentin sensitivity

Symptoms for Dentin Sensitivity

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Drugs & Therapeutics for Dentin Sensitivity

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Dentin Sensitivity

Drug clinical trials:

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Search NIH Clinical Center for Dentin Sensitivity

Search CenterWatch for Dentin Sensitivity

Genetic Tests for Dentin Sensitivity

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Anatomical Context for Dentin Sensitivity

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34MalaCards
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MalaCards organs/tissues related to Dentin Sensitivity:

34
Testes

Animal Models for Dentin Sensitivity or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Dentin Sensitivity:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2ENTPD2, TRPA1, TRPV1
2MP:00053868.1TRPV4, TRPM3, TRPV1, TRPM8, TRPA1, TRPV3
3MP:00107717.7TRPV4, CSN3, TRPV3, TRPA1, TRPM8, TRPV1
4MP:00036317.0KCNK4, KCNK10, ENTPD2, TRPA1, TRPM8, TRPV1

Publications for Dentin Sensitivity

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53PubMed
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Articles related to Dentin Sensitivity:

(show all 26)
idTitleAuthorsYear
1
Randomized trial of the clinical efficacy of a potassium oxalate-containing mouthrinse in rapid relief of dentin sensitivity. (24282871)
2013
2
Biomimetic mineralization: long-term observations in patients with dentin sensitivity. (22305715)
2012
3
Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentin sensitivity. (21168271)
2011
4
Oxalic acid under adhesive restorations as a means to reduce dentin sensitivity: a four-month clinical trial. (21777095)
2011
5
Dentin sensitivity: an oral symptom that should not be neglected]. (19575978)
2009
6
Considerations for the development of over-the-counter dentifrices for the treatment and relief of dentin sensitivity. (19902641)
2009
7
Clinical evaluation of cervical dentin sensitivity (CDS) in patients attending general dental clinics (GDC) and periodontal specialty clinics (PSC). (11908469)
2002
8
Root-dentin sensitivity following non-surgical periodontal treatment. (10983603)
2000
9
The Dentin Disc surface: a plausible model for dentin physiology and dentin sensitivity evaluation. (9470509)
1997
10
Treatment of dentin sensitivity with stannous fluoride gel. Electron microscopic study and evaluation of dentin permeability]. (9567615)
1997
11
Dental pain evoked by hydrostatic pressures applied to exposed dentin in man: a test of the hydrodynamic theory of dentin sensitivity. (7996085)
1994
12
Theory of dentin sensitivity. (8534375)
1994
13
Relation of dentin sensitivity to histological changes in dog teeth with exposed and stimulated dentin. (1508867)
1992
14
Dentin permeability and dentin sensitivity. (1508886)
1992
15
Evaluation of tartar control dentifrices in in vitro models of dentin sensitivity. (1650304)
1991
16
An in vivo study of dentin sensitivity: the relation of dentin sensitivity and the patency of dentin tubules. (1753319)
1991
17
Mechanisms of dentin sensitivity. (2197121)
1990
18
The influence of frequent ingestion of acids in the diet on treatment for dentin sensitivity. (2285881)
1990
19
Double-blind evaluation of duration of dentin sensitivity reduction by fluoride iontophoresis. (2638286)
1989
20
The efficacy of a new dentifrice in treating dentin sensitivity: effects of sodium citrate and sodium fluoride as active ingredients. (2953887)
1987
21
Dentin permeability, dentin sensitivity, and treatment through tubule occlusion. (3465852)
1986
22
Dentin sensitivity: a review. (3860500)
1985
23
Clinical evaluation of the effectiveness of three dentifrices in relieving dentin sensitivity. (6596425)
1984
24
Dentin sensitivity, odontoblasts and nerves under desiccated or infected experimental cavities. A clinical, light microscopic and ultrastructural investigation. (6955990)
1982
25
Dentin sensitivity and aspiration of odontoblasts. (14014982)
1963
26
Sodium fluoride therapy for combating dentin sensitivity and gingival decay. (21008391)
1945

Variations for Dentin Sensitivity

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Expression for genes affiliated with Dentin Sensitivity

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dentin Sensitivity

Search GEO for disease gene expression data for Dentin Sensitivity.

Pathways for genes affiliated with Dentin Sensitivity

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Sources:
51PathCards, 54QIAGEN, 13EMD Millipore, 56Reactome, 61Thomson Reuters, 31KEGG
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Pathways related to Dentin Sensitivity according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6KCNK10, KCNK4
2
Show member pathways
9.0TRPM3, TRPV1, TRPM8
38.8TRPA1, TRPM8, TRPV1, TRPV4
4
Show member pathways
8.8KCNK4, KCNK10, TRPM8
5
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
7.9TRPV2, TRPV3, TRPA1, TRPM8, TRPV1, TRPV4
6
Show member pathways
7.8TRPV2, TRPV3, TRPM8, TRPV1, TRPM3, TRPV4
7
Show member pathways
7.5TRPV2, TRPV3, TRPA1, TRPM8, TRPV1, TRPM3
8
Show member pathways
7.5TRPV2, TRPV3, TRPA1, TRPM8, TRPV1, TRPM3
97.5TRPV4, TRPV2, TRPV3, TRPA1, TRPM8, TRPV1

Compounds for genes affiliated with Dentin Sensitivity

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Sources:
30IUPHAR, 46Novoseek, 25HMDB, 12DrugBank, 62Tocris Bioscience, 52PharmGKB
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Compounds related to Dentin Sensitivity according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1allicin3010.2TRPA1, TRPV1
2camphor30 4611.2TRPV1, TRPV3
3resiniferatoxin46 3011.2TRPV1, TRPV4
4gd3+3010.1TRPM3, TRPV4
5thymol30 4611.0DSPP, TRPV3, TRPA1
6ruthenium4610.0TRPV1, TRPV4
7eugenol46 30 2512.0TRPV1, TRPV3, DSPP
8sodium azide469.9ENTPD2, DSPP
9riluzole46 30 1211.8KCNK10, KCNK4
10dmp 543629.8KCNK4, KCNK10
11ys-035 hydrochloride629.8KCNK4, KCNK10
12bl 1249629.8KCNK4, KCNK10
13tetraethylammonium chloride629.8KCNK4, KCNK10
14halothane46 52 30 1212.8DSPP, KCNK10
15icilin30 6210.7TRPA1, TRPM8
16nada309.7TRPM8, TRPV1
17cesium chloride46 6210.7KCNK10, KCNK4
18bctc309.7TRPM8, TRPV1
19diphenylboronic anhydride309.6TRPV1, TRPV3, TRPV2
20hydroxyapatite469.5CSN3, DSPP
21amiloride46 30 1211.5TRPV1, TRPV2
225-iodoresiniferatoxin62 3010.4TRPV2, TRPV3, TRPV1, TRPV4
23amg 9810629.4TRPV4, TRPV1, TRPV3, TRPV2
24hc 067047629.4TRPV2, TRPV3, TRPV1, TRPV4
25cannabidiol30 4610.3TRPV2, TRPM8
26potassium46 25 1211.3KCNK4, KCNK10, TRPV1
27arachidonic acid46 30 25 1212.3TRPV4, TRPV1, KCNK10, KCNK4
28menthol46 30 25 1212.2TRPV3, TRPA1, TRPM8, TRPV1
29delta9-tetrahydrocannabinol309.1TRPV2, TRPA1, TRPM8
302-apb30 6210.1TRPV3, TRPM8, TRPV1, TRPM3
31ruthenium red309.1TRPV4, TRPV2, TRPV3, TRPA1, TRPV1
32sodium46 2510.0TRPV4, TRPV1, TRPM8
33la3+308.8TRPV4, TRPM3, TRPM8, TRPV2
34capsazepine62 46 3010.5TRPV2, TRPV3, TRPM8, TRPV1, TRPV4
35capsaicin46 309.5TRPV2, TRPA1, TRPM8, TRPV1, TRPV4
36anandamide62 46 30 2511.5TRPV2, TRPV3, TRPM8, TRPV1, TRPV4
37calcium46 52 25 1210.0DSPP, CSN3, ENTPD2, TRPV2, TRPV3, TRPM8

GO Terms for genes affiliated with Dentin Sensitivity

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17Gene Ontology
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Cellular components related to Dentin Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of membraneGO:0160217.1KCNK10, ENTPD2, TRPV3, TRPM8, TRPV1, TRPM3
2plasma membraneGO:0058865.9TRPV4, KCNK4, KCNK10, ENTPD2, TRPV2, TRPV3

Biological processes related to Dentin Sensitivity according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcium ion importGO:0902809.6TRPV3, TRPV2
2response to heatGO:0094089.5TRPV3, TRPV2
3response to coldGO:0094099.4TRPA1, TRPM8
4cellular calcium ion homeostasisGO:0068749.3TRPV4, TRPM8
5thermoceptionGO:0509559.2TRPV1, TRPM8, TRPA1
6transportGO:0068108.7TRPV1, TRPV2, KCNK10
7calcium ion transmembrane transportGO:0705887.7TRPV4, TRPV2, TRPV3, TRPA1, TRPM8, TRPV1
8ion transmembrane transportGO:0342207.7TRPV2, TRPV3, TRPA1, TRPM8, TRPV1, TRPM3
9transmembrane transportGO:0550857.7TRPV2, TRPV3, TRPA1, TRPM8, TRPV1, TRPM3

Molecular functions related to Dentin Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel activityGO:0052679.6KCNK10, KCNK4
2voltage-gated ion channel activityGO:0052449.3KCNK10, KCNK4
3cation channel activityGO:0052619.1TRPV2, TRPM3, TRPV4
4calcium channel activityGO:0052627.5TRPV4, TRPM3, TRPV1, TRPM8, TRPA1, TRPV3

Products for genes affiliated with Dentin Sensitivity

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  • Proteins
  • Lysates
  • Antibodies

Sources for Dentin Sensitivity

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet