MCID: DNT007
MIFTS: 29

Dentin Sensitivity malady

Summaries for Dentin Sensitivity

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33MalaCards
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MalaCards: Dentin Sensitivity, also known as sensitive dentin, is related to cholera and migraine. An important gene associated with Dentin Sensitivity is DSPP (dentin sialophosphoprotein), and among its related pathways are Sodium channels and transporters: inward current and Calcium channels. The compounds allicin and camphor have been mentioned in the context of this disorder. Related mouse phenotypes are behavior/neurological and integument.

Aliases & Classifications for Dentin Sensitivity

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

dentin sensitivity 8 10 45 61
sensitive dentin 8


External Ids:

Disease Ontology8 DOID:698
NCIt40 C50778
SNOMED-CT57 13468005
MeSH35 D003807

Related Diseases for Dentin Sensitivity

Sources:
17GeneCards, 18GeneDecks
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Diseases in the dentin dysplasia family:

dentin sensitivity dentin dysplasia, type 1
dentin dysplasia, type ii dentin dysplasia, type i, with microdontia and misshapen teeth

Diseases related to Dentin Sensitivity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1cholera10.0ENTPD2
2migraine10.0TRPV1
3neuropathy10.0TRPV4, TRPV1
4pulpitis10.0TRPV1, DSPP
5pain agnosia10.0TRPM8, TRPA1, TRPV1

Graphical network of diseases related to Dentin Sensitivity:



Diseases related to dentin sensitivity

Clinical Features for Dentin Sensitivity

Drugs & Therapeutics for Dentin Sensitivity

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Dentin Sensitivity

Drug clinical trials:

Search ClinicalTrials for Dentin Sensitivity

Search NIH Clinical Center for Dentin Sensitivity

Search CenterWatch for Dentin Sensitivity

Genetic Tests for Dentin Sensitivity

Anatomical Context for Dentin Sensitivity

Animal Models for Dentin Sensitivity or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Dentin Sensitivity:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.0KCNK2, TRPA1, TRPV1, TRPV3, TRPV4, TRPM8
2MP:00107717.9TRPM3, TRPM8, TRPV4, TRPV3, TRPV1, TRPA1
3MP:00036316.5TRPA1, KCNK2, ARHGAP32, KCNK4, TRPV1, TRPV4

Publications for Dentin Sensitivity

Sources:
51PubMed
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Articles related to Dentin Sensitivity:

(show all 32)
idTitleAuthorsYear
1
Randomized trial of the clinical efficacy of a potassium oxalate-containing mouthrinse in rapid relief of dentin sensitivity. (24282871)
2013
2
Biomimetic mineralization: long-term observations in patients with dentin sensitivity. (22305715)
2012
3
Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentin sensitivity. (21168271)
2011
4
Oxalic acid under adhesive restorations as a means to reduce dentin sensitivity: a four-month clinical trial. (21777095)
2011
5
Dentin sensitivity: an oral symptom that should not be neglected]. (19575978)
2009
6
Dentin hypersensitivity: from diagnosis to a breakthrough therapy for everyday sensitivity relief. (19489186)
2009
7
Considerations for the development of over-the-counter dentifrices for the treatment and relief of dentin sensitivity. (19902641)
2009
8
The effect of anti-sensitivity dentifrices on brushing abrasion of eroded dentin in vitro. (19278085)
2008
9
Clinical effectiveness of dentin sealer in treating dental root sensitivity following periodontal surgery. (16607061)
2006
10
Clinical evaluation of two adhesive composite cements for the suppression of dentinal cold sensitivity. (12239480)
2002
11
Clinical evaluation of cervical dentin sensitivity (CDS) in patients attending general dental clinics (GDC) and periodontal specialty clinics (PSC). (11908469)
2002
12
The sensitivity and specificity of clinical assessment compared with bitewing radiography for detection of occlusal dentin caries. (11447949)
2001
13
Root-dentin sensitivity following non-surgical periodontal treatment. (10983603)
2000
14
Technique sensitivity of dentin bonding: effect of application mistakes on bond strength and marginal adaptation. (11203838)
2000
15
The Dentin Disc surface: a plausible model for dentin physiology and dentin sensitivity evaluation. (9470509)
1997
16
Treatment of dentin sensitivity with stannous fluoride gel. Electron microscopic study and evaluation of dentin permeability]. (9567615)
1997
17
Dental pain evoked by hydrostatic pressures applied to exposed dentin in man: a test of the hydrodynamic theory of dentin sensitivity. (7996085)
1994
18
Theory of dentin sensitivity. (8534375)
1994
19
Relation of dentin sensitivity to histological changes in dog teeth with exposed and stimulated dentin. (1508867)
1992
20
Dentin permeability and dentin sensitivity. (1508886)
1992
21
Evaluation of tartar control dentifrices in in vitro models of dentin sensitivity. (1650304)
1991
22
An in vivo study of dentin sensitivity: the relation of dentin sensitivity and the patency of dentin tubules. (1753319)
1991
23
Mechanisms of dentin sensitivity. (2197121)
1990
24
The influence of frequent ingestion of acids in the diet on treatment for dentin sensitivity. (2285881)
1990
25
Double-blind evaluation of duration of dentin sensitivity reduction by fluoride iontophoresis. (2638286)
1989
26
The efficacy of a new dentifrice in treating dentin sensitivity: effects of sodium citrate and sodium fluoride as active ingredients. (2953887)
1987
27
Dentin permeability, dentin sensitivity, and treatment through tubule occlusion. (3465852)
1986
28
Dentin sensitivity: a review. (3860500)
1985
29
Clinical evaluation of the effectiveness of three dentifrices in relieving dentin sensitivity. (6596425)
1984
30
Dentin sensitivity, odontoblasts and nerves under desiccated or infected experimental cavities. A clinical, light microscopic and ultrastructural investigation. (6955990)
1982
31
Dentin sensitivity and aspiration of odontoblasts. (14014982)
1963
32
Sodium fluoride therapy for combating dentin sensitivity and gingival decay. (21008391)
1945

Genetic Variations for Dentin Sensitivity

Expression for genes affiliated with Dentin Sensitivity

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dentin Sensitivity

Search GEO for disease gene expression data for Dentin Sensitivity.

Pathways for genes affiliated with Dentin Sensitivity

Sources:
12EMD Millipore, 52QIAGEN, 54Reactome
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Compounds for genes affiliated with Dentin Sensitivity

Sources:
29IUPHAR, 45Novoseek, 24HMDB, 60Tocris Bioscience, 11DrugBank, 50PharmGKB
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Compounds related to Dentin Sensitivity according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1allicin2910.2TRPA1, TRPV1
2camphor45 2911.1TRPV3, TRPV1
3thymol45 2911.1TRPV3, TRPA1, DSPP
4resiniferatoxin45 2911.1TRPV1, TRPV4
5eugenol45 29 2412.1DSPP, TRPV1, TRPV3
6bctc2910.0TRPV1, TRPM8
7ruthenium4510.0TRPV4, TRPV1
8icilin29 6011.0TRPA1, TRPM8
9nada299.9TRPV1, TRPM8
10gd3+299.9TRPM3, TRPV4
11diphenylboronic anhydride299.8TRPV2, TRPV3, TRPV1
125-iodoresiniferatoxin60 2910.6TRPV1, TRPV3, TRPV4, TRPV2
13amg 9810609.6TRPV2, TRPV4, TRPV3, TRPV1
14hc 067047609.6TRPV1, TRPV3, TRPV4, TRPV2
15sodium azide459.6ENTPD2, DSPP
16δ9-tetrahydrocannabinol299.6TRPV2, TRPM8, TRPA1
17cannabidiol29 4510.6TRPM8, TRPV2
18menthol45 29 11 2412.6TRPA1, TRPV1, TRPV3, TRPM8
192-apb29 6010.5TRPV1, TRPV3, TRPM8, TRPM3
20ruthenium red299.4TRPA1, TRPV1, TRPV3, TRPV4, TRPV2
21riluzole45 29 1111.3KCNK4, KCNK10, KCNK2
22dmp 543609.3KCNK4, KCNK10, KCNK2
23ys-035 hydrochloride609.3KCNK4, KCNK10, KCNK2
24bl 1249609.3KCNK4, KCNK10, KCNK2
25la3+299.3TRPV2, TRPM3, TRPM8, TRPV4
26tetraethylammonium chloride609.3KCNK4, KCNK10, KCNK2
27cesium chloride45 6010.3KCNK4, KCNK10, KCNK2
28halothane45 29 1111.3DSPP, KCNK2, KCNK10
29capsaicin45 2910.1TRPA1, TRPV1, TRPV4, TRPM8, TRPV2
30capsazepine45 60 2911.1TRPV2, TRPV1, TRPV3, TRPV4, TRPM8
31anandamide45 29 60 2412.1TRPV1, TRPV3, TRPV4, TRPM8, TRPV2
32arachidonic acid45 29 11 2411.7KCNK4, KCNK10, KCNK2, TRPV1, TRPV4
33potassium45 11 2410.7KCNK4, KCNK10, KCNK2, TRPV1
34calcium45 50 11 2410.0CSN3, ARHGAP32, DSPP, TRPV1, TRPV3, TRPV4

GO Terms for genes affiliated with Dentin Sensitivity

Sources:
16Gene Ontology
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Cellular components related to Dentin Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to membraneGO:0160217.7ENTPD2, TRPM3, TRPM8, TRPV4, TRPV3, TRPV1

Biological processes related to Dentin Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to coldGO:0094099.7TRPM8, TRPA1
2response to temperature stimulusGO:0092669.4TRPV2, TRPV3
3thermoceptionGO:0509559.4TRPM8, TRPV1, TRPA1

Molecular functions related to Dentin Sensitivity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1potassium channel activityGO:0052679.6KCNK10, KCNK4
2cation channel activityGO:0052619.4TRPV4, TRPM3, TRPV2
3voltage-gated ion channel activityGO:0052449.3KCNK10, KCNK4
4calcium channel activityGO:0052628.2TRPV2, TRPM3, TRPM8, TRPV4, TRPV3, TRPV1

Products for genes affiliated with Dentin Sensitivity

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  • Antibodies

Sources for Dentin Sensitivity

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet