MCID: DNT008
MIFTS: 41

Denture Stomatitis

Categories: Oral diseases

Aliases & Classifications for Denture Stomatitis

MalaCards integrated aliases for Denture Stomatitis:

Name: Denture Stomatitis 12 14
Stomatitis, Denture 41 69
Denture Sore Mouth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11875
ICD10 32 K12.1
MeSH 41 D013282
SNOMED-CT 64 196576008 69254008
UMLS 69 C0038364

Summaries for Denture Stomatitis

MalaCards based summary : Denture Stomatitis, also known as stomatitis, denture, is related to peritonitis and stomatitis. An important gene associated with Denture Stomatitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Toll-like receptor signaling pathway and IL-17 Family Signaling Pathways. The drugs Miconazole and Nystatin have been mentioned in the context of this disorder. Affiliated tissues include colon, neutrophil and monocytes.

Related Diseases for Denture Stomatitis

Diseases related to Denture Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 peritonitis 30.0 CCL2 CXCL8 IL6
2 stomatitis 11.1
3 recurrent corneal erosion 10.4 CXCL8 IL6
4 bagassosis 10.4 CXCL8 IL6
5 acute transverse myelitis 10.4 CXCL8 IL6
6 streptococcal toxic-shock syndrome 10.4 CXCL8 IL6
7 papillary conjunctivitis 10.4 CXCL8 IL6
8 funisitis 10.4 CXCL8 IL6
9 acute monoblastic leukemia 10.4 CXCL8 IL6
10 capillary leak syndrome 10.4 CXCL8 IL6
11 meconium aspiration syndrome 10.4 CXCL8 IL6
12 vaginal disease 10.4 CXCL8 IL6
13 louse-borne relapsing fever 10.4 CXCL8 IL6
14 vaginitis 10.4 CXCL8 IL6
15 preterm premature rupture of the membranes 10.4 CXCL8 IL6
16 endometrial disease 10.4 CXCL8 IL6
17 transverse myelitis 10.4 CXCL8 IL6
18 necrotizing fasciitis 10.4 CXCL8 IL6
19 herpes simplex virus keratitis 10.4 CCL2 CXCL8
20 cowpox 10.4 CXCL8 IL6
21 israeli tick typhus 10.4 CCL2 CXCL8
22 pulpitis 10.4 CXCL8 IL6
23 cytomegalovirus infection 10.4 CXCL8 IL6
24 perinatal necrotizing enterocolitis 10.4 CXCL8 IL6
25 fasciitis 10.4 CXCL8 IL6
26 acute respiratory distress syndrome 10.4 CXCL8 IL6
27 tuberculous meningitis 10.4 CCL2 CXCL8
28 stachybotrys chartarum 10.4 CCL2 IL6
29 pleural tuberculosis 10.4 CCL2 CXCL8
30 uterine anomalies 10.4 CXCL8 IL6
31 mesangial proliferative glomerulonephritis 10.3 CCL2 IL6
32 bacterial vaginosis 10.3 CXCL8 IL6
33 ischemic heart disease 10.3 CCL2 IL6
34 post-thrombotic syndrome 10.3 CCL2 IL6
35 prostatitis 10.3 CXCL8 IL6
36 radiculopathy 10.3 CCL2 IL6
37 stromal keratitis 10.3 CCL2 IL6
38 interstitial cystitis 10.3 CXCL8 IL6
39 avian influenza 10.3 CXCL8 IL6
40 pleurisy 10.3 CCL2 CXCL8
41 pulmonary disease, chronic obstructive 10.3 CXCL8 IL6
42 proliferative glomerulonephritis 10.3 CCL2 IL6
43 diabetic macular edema 10.3 CCL2 IL6
44 brucellosis 10.3 CXCL8 IL6
45 placenta disease 10.3 CXCL8 IL6
46 dengue shock syndrome 10.3 CCL2 IL6
47 appendicitis 10.3 CXCL8 IL6
48 extrinsic cardiomyopathy 10.3 CCL2 IL6
49 complex regional pain syndrome 10.3 CCL2 IL6
50 dengue hemorrhagic fever 10.3 CXCL8 IL6

Graphical network of the top 20 diseases related to Denture Stomatitis:



Diseases related to Denture Stomatitis

Symptoms & Phenotypes for Denture Stomatitis

Drugs & Therapeutics for Denture Stomatitis

Drugs for Denture Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
2
Nystatin Approved, Vet_approved Phase 4,Phase 2 1400-61-9 11953884
3
Methylene blue Approved, Investigational Phase 4 61-73-4
4 Anti-Bacterial Agents Phase 4,Phase 2
5 Antifungal Agents Phase 4,Phase 3,Phase 2
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2
7 Ionophores Phase 4,Phase 2
8 Pharmaceutical Solutions Phase 4
9 Anti-Infective Agents, Local Phase 3
10 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
11 Cytochrome P-450 CYP3A Inhibitors Phase 3
12 Cytochrome P-450 Enzyme Inhibitors Phase 3
13 Hormone Antagonists Phase 3
14 Hormones Phase 3
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
16 Propolis Phase 3
17 Steroid Synthesis Inhibitors Phase 3
18 Bee Products Nutraceutical Phase 3
19
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
20 Garlic Approved, Nutraceutical Phase 2
21 Titanium dioxide Approved Phase 1 13463-67-7
22 Dermatologic Agents Phase 1
23 Photosensitizing Agents Phase 1
24 Protective Agents Phase 1
25 Radiation-Protective Agents Phase 1
26 Sunscreening Agents Phase 1
27
Chlorhexidine Approved, Vet_approved 55-56-1 2713 9552079
28
Mechlorethamine Approved, Investigational 51-75-2 4033
29
Sage Approved, Nutraceutical Not Applicable
30 Chlorhexidine gluconate
31 Disinfectants
32 Eusol
33 Sodium hypochlorite
34 Alkylating Agents
35 chloramine-T
36 Anti-Inflammatory Agents Not Applicable

Interventional clinical trials:

(show all 14)

# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy Against Candida Spp. in Complete Denture Wearers Completed NCT02642900 Phase 4 Nystatin 100.000 units
2 Efficacy of Standardized-propolis Extract (EPP-AF®) Gel Formulation as Buccal Antiseptic Completed NCT02818803 Phase 3 Miconazole
3 Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis Completed NCT01198223 Phase 2 garlic , nystatin
4 Efficacy of Slow Release Clotrimazole Varnish Treating Denture Stomatitis Comparing to Traditional Treatment of Troches Completed NCT00835029 Phase 2 Clotrimazole varnish;Clotrimazole troches
5 The Effect of Palatal Brushing on Denture Stomatitis Completed NCT01643876 Phase 1
6 Surface Roughness of Heat Cured Acrylic Resin Versus Acrylic Resin With Titanium Dioxide Not yet recruiting NCT02950584 Phase 1
7 Effects of Denture-Related Stomatitis on Blood Pressure in Denture Wearers Unknown status NCT02166450 Nystatin
8 Hygiene Protocol of Complete Dentures Completed NCT01906242
9 Experimental Denture Pastes Completed NCT01237795
10 Efficacy of a Propolis-based Denture Cleanser Completed NCT01237782 Denture soaking solution;Saline solution
11 The Effectiveness of Palatal Brushing on Denture Stomatitis Recruiting NCT02686632
12 Novel Coating to Minimize Bacterial Adhesions and Tooth Wear in Denture Acrylic Recruiting NCT02834832
13 Clinical Trial for Evaluating Sage-Based Mouthrinse Recruiting NCT02830802 Not Applicable
14 Microbiological Study on Maxillary Complete Dentures of Two Different Materials Not yet recruiting NCT02950623

Search NIH Clinical Center for Denture Stomatitis

Cochrane evidence based reviews: stomatitis, denture

Genetic Tests for Denture Stomatitis

Anatomical Context for Denture Stomatitis

MalaCards organs/tissues related to Denture Stomatitis:

38
Colon, Neutrophil, Monocytes, Testes, Tongue, T Cells, Endothelial

Publications for Denture Stomatitis

Articles related to Denture Stomatitis:

(show top 50) (show all 250)
# Title Authors Year
1
Cytokine gene polymorphism in denture stomatitis patients: A clinical study. ( 29423993 )
2018
2
Oral Candida carriage and species prevalence in denture stomatitis patients with and without diabetes. ( 28685534 )
2017
3
Efficacy of photodynamic therapy in the inactivation of oral fungal colonization among cigarette smokers and non-smokers with denture stomatitis. ( 28130176 )
2017
4
Inhibitory effect of zirconium oxide nanoparticles on Candida albicans adhesion to repaired polymethyl methacrylate denture bases and interim removable prostheses: a new approach for denture stomatitis prevention. ( 28814859 )
2017
5
Laboratory-Based Investigation of Denture Sonication Method in Patients with Candida-Associated Denture Stomatitis. ( 28872720 )
2017
6
Antimicrobial Photodynamic Therapy mediated by Photodithazine<sup>Ar</sup>in the treatment of denture stomatitis: a case report. ( 29198763 )
2017
7
Phagocytosis and nitric oxide production by peritoneal adherent cells in response to Candida albicans in aging: a collaboration to elucidate the pathogenesis of denture stomatitis. ( 28678945 )
2017
8
Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial. ( 28396692 )
2017
9
In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida albicans in Denture Stomatitis Prevention. ( 28698449 )
2017
10
Denture Stomatitis: Causes, Cures and Prevention. ( 29258641 )
2017
11
Characterization of a novel antibiofilm effect of nitric oxide-releasing aspirin (NCX-4040) on Candida albicans isolates from denture stomatitis patients. ( 28493889 )
2017
12
Surface Roughness Changes in Denture Liners in Denture Stomatitis Patients. ( 29084304 )
2017
13
Nystatin and disinfectant solutions seem to be effective in treating denture stomatitis. ( 28242007 )
2017
14
Systemic T Cells and Monocyte Characteristics in Patients with Denture Stomatitis. ( 26883670 )
2016
15
EVALUATION OF DENTURE-RELATED FACTORS PREDISPOSING TO DENTURE STOMATITIS IN A LEBANESE POPULATION. ( 27999492 )
2016
16
Sustained drug-delivery system: a promising therapy for denture stomatitis? ( 27812610 )
2016
17
Clinical study on thermography, as modern investigation method for Candida-associated denture stomatitis. ( 27151707 )
2016
18
Fabrication and Evaluation of Nanostructured Herbal Oil/Hydroxypropyl-I^-Cyclodextrin/Polyvinylpyrrolidone Mats for Denture Stomatitis Prevention and Treatment. ( 26821915 )
2016
19
Transcription Factors Efg1 and Bcr1 Regulate Biofilm Formation and Virulence during Candida albicans-Associated Denture Stomatitis. ( 27453977 )
2016
20
Interventions for the Management of Denture Stomatitis: A Systematic Review and Meta-Analysis. ( 27889906 )
2016
21
Antifungal Effect of Henna against Candida albicans Adhered to Acrylic Resin as a Possible Method for Prevention of Denture Stomatitis. ( 27223294 )
2016
22
Denture Stomatitis and Candida Albicans in Iranian Population: A Systematic Review and Meta-Analysis. ( 27840842 )
2016
23
Production of virulence factors in Candida strains isolated from patients with denture stomatitis and control individuals. ( 26971635 )
2016
24
Decreased production of proinflammatory cytokines by monocytes from individuals presenting Candida-associated denture stomatitis. ( 26587801 )
2016
25
Candida albicans biofilm heterogeneity does not influence denture stomatitis, but strongly influences denture cleansing capacity. ( 28032543 )
2016
26
Evidence Regarding the Treatment of Denture Stomatitis. ( 27062660 )
2016
27
Invitro Antifungal Evaluation of Denture Soft Liner Incorporated with Tea Tree Oil: A New Therapeutic Approach Towards Denture Stomatitis. ( 26266221 )
2015
28
Expression of Secreted Aspartyl Proteinases in an Experimental Model of Candida albicans-Associated Denture Stomatitis. ( 25857681 )
2015
29
Methylene Blue-Mediated Photodynamic Inactivation Followed by Low-Laser Therapy versus Miconazole Gel in the Treatment of Denture Stomatitis. ( 26375599 )
2015
30
A case with tumor of left parotid gland and denture stomatitis. ( 25826511 )
2015
31
The Beneficial Effect of Equisetum giganteum L. against Candida Biofilm Formation: New Approaches to Denture Stomatitis. ( 26290676 )
2015
32
Uncaria tomentosa Gel against Denture Stomatitis: Clinical Report. ( 25675972 )
2015
33
Photodynamic inactivation of virulence factors of Candida strains isolated from patients with denture stomatitis. ( 26398815 )
2015
34
Phase 1 clinical trial on the effect of palatal brushing on denture stomatitis. ( 25010873 )
2014
35
Antifungal medications or disinfectants for denture stomatitis. ( 24971864 )
2014
36
Use of Candida-specific chicken egg yolk antibodies to inhibit the adhering of Candida to denture base materials: prevention of denture stomatitis. ( 25393605 )
2014
37
Antifungal Activity of Apple Cider Vinegar on Candida Species Involved in Denture Stomatitis. ( 25219289 )
2014
38
Role of salivary and candidal proteins in denture stomatitis: an exploratory proteomic analysis. ( 24947908 )
2014
39
Evaluation of different treatment methods against denture stomatitis: a randomized clinical study. ( 24908596 )
2014
40
Is denture stomatitis always related with candida infection? A case control study. ( 25082257 )
2014
41
Linking evidence to treatment for denture stomatitis: A meta-analysis of randomized controlled trials. ( 24316341 )
2014
42
Susceptibility profile of a Brazilian yeast stock collection of Candida species isolated from subjects with Candida-associated denture stomatitis with or without diabetes. ( 24055150 )
2013
43
Risk factors associated with denture stomatitis in healthy subjects attending a dental school in southeast iran. ( 24273669 )
2013
44
Effects of lawsone methyl ether mouthwash on oral Candida in HIV-infected subjects and subjects with denture stomatitis. ( 23586936 )
2013
45
Clinical and histological findings of denture stomatitis as related to intraoral colonization patterns of Candida albicans, salivary flow, and dry mouth. ( 23107189 )
2013
46
Denture stomatitis and salivary vascular endothelial growth factor in immediate complete denture wearers with type 2 diabetes. ( 24355506 )
2013
47
Does the presence of anterior mandibular teeth increase the incidence of denture stomatitis? ( 22984815 )
2013
48
Opportunistic microorganisms in individuals with lesions of denture stomatitis. ( 23747028 )
2013
49
Treatment protocol for denture stomatitis, prior to anatomical molding. ( 22506854 )
2013
50
Ricinus communis treatment of denture stomatitis in institutionalised elderly. ( 23438045 )
2013

Variations for Denture Stomatitis

Expression for Denture Stomatitis

Search GEO for disease gene expression data for Denture Stomatitis.

Pathways for Denture Stomatitis

Pathways related to Denture Stomatitis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 CCL2 CXCL8 IL6
2
Show member pathways
12.03 CCL2 CXCL8 IL6
3 11.73 CCL2 CXCL8 IL6
4
Show member pathways
11.7 CCL2 CXCL8 CXCR1
5 11.67 CCL2 CXCL8 IL6
6 11.58 CCL2 CXCL8 IL6
7 11.5 CCL2 CXCL8 IL6
8
Show member pathways
11.33 CCL2 CXCL8
9 11.31 CXCL8 IL6
10 11.3 CXCL8 IL6
11 11.3 CCL2 CXCL8 IL6
12 11.22 CXCR1 IL6
13 11.14 CXCL8 CXCR1 IL6
14 11.02 CCL2 CXCL8 IL6
15 10.92 CCL2 CXCL8 IL6
16 10.82 CCL2 CXCL8 IL6
17 10.77 CXCL8 IL6
18 10.33 CCL2 CXCL8 IL6

GO Terms for Denture Stomatitis

Biological processes related to Denture Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.5 CCL2 CXCL8 CXCR1
2 humoral immune response GO:0006959 9.46 CCL2 IL6
3 inflammatory response GO:0006954 9.46 CCL2 CXCL8 CXCR1 IL6
4 monocyte chemotaxis GO:0002548 9.43 CCL2 IL6
5 receptor internalization GO:0031623 9.4 CXCL8 CXCR1
6 cellular response to fibroblast growth factor stimulus GO:0044344 9.37 CCL2 CXCL8
7 PERK-mediated unfolded protein response GO:0036499 9.26 CCL2 CXCL8
8 chemokine-mediated signaling pathway GO:0070098 9.13 CCL2 CXCL8 CXCR1
9 cellular response to lipopolysaccharide GO:0071222 8.92 BCR CCL2 CXCL8 IL6

Molecular functions related to Denture Stomatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.96 CCL2 CXCL8
2 cytokine activity GO:0005125 8.8 CCL2 CXCL8 IL6

Sources for Denture Stomatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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