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MCID: DPN001
MIFTS: 34

Dependent Personality Disorder malady

Categories: Mental diseases
Genes Related diseases Publications Pathways Drugs
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Aliases & Classifications for Dependent Personality Disorder

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Aliases & Descriptions for Dependent Personality Disorder:

Name: Dependent Personality Disorder 12 42 14 69

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:10931
ICD10 33 F60.7
ICD9CM 35 301.6
MeSH 42 D003859
NCIt 47 C92637
UMLS 69 C0011548
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Summaries for Dependent Personality Disorder

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Disease Ontology : 12 A personality disorder that is characterized by a pervasive psychological dependence on other people.

MalaCards based summary : Dependent Personality Disorder is related to personality disorder and conjunctival pigmentation. An important gene associated with Dependent Personality Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are superpathway of tryptophan utilization and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Citalopram and Fluoxetine have been mentioned in the context of this disorder. Related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 71 Dependent personality disorder (DPD), formerly known as asthenic personality disorder, is a personality... more...

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Related Diseases for Dependent Personality Disorder

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Diseases related to Dependent Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
id Related Disease Score Top Affiliating Genes
1 personality disorder 29.7 DRD4 MAOA RTN4 WASF1 WASF2
2 conjunctival pigmentation 10.2 MAOA MAOB
3 lethal congenital contracture syndrome 1 10.2 MAOA MAOB
4 colorectal adenocarcinoma 10.2 DRD4 MAOA
5 pyromania 10.1 DRD4 MAOA MAOB
6 cecal benign neoplasm 10.1 DRD4 MAOA MAOB
7 tinea pedis 10.1 CYP3A4 MAOA
8 hepatitis b reinfection following liver transplantation 10.1 CYP3A4 MAOA MAOB
9 benign epilepsy with centrotemporal spikes 10.1 DRD4 MAOA MAOB
10 tuberculoid leprosy 10.1 MAOA MAOB TNFSF11
11 xanthomatosis 10.1 KNTC1 MME
12 strongyloidiasis 10.0 MAOA MAOB
13 mycobacterium avium complex disease 10.0 SMPD1 WASF2
14 hepatitis e 10.0 KNTC1 SMPD1
15 basal cell carcinoma 3 9.9 MAOA WASF1 WASF2
16 chronic cervicitis 9.7 MAOA MME WASF1 WASF2
17 schizophrenia 9.7 CYP3A4 DRD4 MAOA MAOB RTN4
18 alexithymia 9.7
19 keratosis 9.7 MAOA RTN4 WASF1 WASF2
20 panic disorder 9.6
21 separation anxiety disorder 9.6
22 social phobia 9.6
23 dementia 9.6
24 anxiety disorder 9.6
25 substance dependence 9.6
26 cocaine dependence 9.6
27 dissociative disorder 8.3 ATG4C CYP3A4 DRD4 KNTC1 LRG1 MAOA

Comorbidity relations with Dependent Personality Disorder via Phenotypic Disease Network (PDN): (show all 19)


Acute Cystitis Anxiety Disorder
Avoidant Personality Disorder Borderline Personality Disorder
Dysthymic Disorder Esophagitis
Generalized Anxiety Disorder Histrionic Personality Disorder
Hypertension, Essential Hypochondriasis
Hypothyroidism Irritable Bowel Syndrome
Narcissistic Personality Disorder Obsessive-Compulsive Disorder
Obsessive-Compulsive Personality Disorder Parkinson Disease, Late-Onset
Personality Disorder Schizophreniform Disorder
Somatization Disorder

Graphical network of the top 20 diseases related to Dependent Personality Disorder:



Diseases related to Dependent Personality Disorder
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Symptoms & Phenotypes for Dependent Personality Disorder

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MGI Mouse Phenotypes related to Dependent Personality Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 MAOB SMPD1 TNFSF11 WASF1 ATG4C DRD4
2 homeostasis/metabolism MP:0005376 9.28 ATG4C DRD4 KNTC1 MAOA MAOB MME
Sources

Drugs & Therapeutics for Dependent Personality Disorder

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Drugs for Dependent Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4 59729-33-8 2771
2
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
3
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
4
Sertraline Approved Phase 4 79617-96-2 68617
5
Heroin Approved, Illicit Phase 4 561-27-3 5462328
6
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
7 Antipsychotic Agents Phase 4,Phase 1
8 Central Nervous System Depressants Phase 4,Phase 2,Phase 1
9 Psychotropic Drugs Phase 4,Phase 1
10 Quetiapine Fumarate Phase 4 111974-72-2
11 Tranquilizing Agents Phase 4,Phase 1
12 Narcotics Phase 4,Phase 3
13 Peripheral Nervous System Agents Phase 4,Phase 1
14 Narcotic Antagonists Phase 4
15
Ethanol Approved Phase 3,Phase 2 64-17-5 702
16
Acamprosate Approved, Investigational Phase 2 77337-76-9 71158
17
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
18 Anti-Infective Agents Phase 2
19 Anti-Infective Agents, Local Phase 2
20 Antioxidants Phase 2,Phase 1
21 Protective Agents Phase 2,Phase 1
22 Antidotes Phase 2
23 Antiviral Agents Phase 2
24 Expectorants Phase 2
25 N-monoacetylcystine Phase 2
26 Respiratory System Agents Phase 2
27 Glutamic Acid Nutraceutical Phase 2
28 glutamine Nutraceutical Phase 2
29
Dopamine Approved Phase 1 51-61-6, 62-31-7 681
30
Pramipexole Approved, Investigational Phase 1 104632-26-0 59868 119570
31
Sulpiride Approved Phase 1 15676-16-1 5355
32
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
33
Prednisone Approved, Vet_approved Phase 1 53-03-2 5865
34
Docetaxel Approved May 1996, Investigational Phase 1 114977-28-5 148124 9877265
35 Antidepressive Agents Phase 1
36 Antidepressive Agents, Second-Generation Phase 1
37 Antiparkinson Agents Phase 1
38 Autonomic Agents Phase 1
39 Central Nervous System Stimulants Phase 1
40 Dopamine Agents Phase 1
41 Dopamine agonists Phase 1
42 Dopamine Antagonists Phase 1
43 Neurotransmitter Agents Phase 1
44 sultopride Phase 1
45 Antiemetics Phase 1
46 Anti-Inflammatory Agents Phase 1
47 Antimitotic Agents Phase 1
48 Antineoplastic Agents, Hormonal Phase 1
49 BB 1101 Phase 1
50 Dexamethasone 21-phosphate Phase 1

Interventional clinical trials:

(show all 19)
id Name Status NCT ID Phase
1 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4
2 Biomarkers of Injectable Extended Release Naltrexone Treatment Enrolling by invitation NCT02324725 Phase 4
3 Making Alcoholics Anonymous Easier Completed NCT01382316 Phase 3
4 Acamprosate to Reduce Symptoms of Alcohol Withdrawal Completed NCT00106106 Phase 2
5 N-Acetylcysteine in Adjunct to DBT for the Treatment of Self-Injurious Behavior in BPD Terminated NCT00539188 Phase 2
6 Characterize The Modulatory Effects Of Dopamine D2/D3 Receptor Agonist And Antagonist Drugs On Compulsive Behaviors Completed NCT00471588 Phase 1
7 Reducing Dexamethasone Around Docetaxel Infusion Recruiting NCT02776436 Phase 1
8 Differential Efficacy of Supportive and Interpretative Psychodynamic Techniques for Dependent and Self-critical Depressive Patients Unknown status NCT01640483
9 Epidemiological Studies of Eating Disorders in Gifted Dance Students (2nd Year). Completed NCT00173160
10 Reward Processing in Cocaine Addiction Completed NCT01036074
11 Narrative Exposure Therapy in Women With Borderline Personality Disorder and Posttraumatic Stress Disorder Recruiting NCT02517723
12 Training of Neural Responding in BPD Recruiting NCT02866110
13 Personality Pathology and Cerebral Processing in Eating Disorders Recruiting NCT02980120
14 Characterization Imaging Instruments in Alcoholics and Non-Alcoholics Recruiting NCT02108080
15 Endogenous Opioid Mechanisms for Rejection Sensitivity Recruiting NCT02189785
16 Vulnerability Markers in Pathological Gambling Recruiting NCT02873572
17 Risk Factors Associated With Binge Drinking Behaviors Among College Students Recruiting NCT02794311
18 Inhibitory Control of the Mind : Neural Bases and Impact for Obsessive-compulsive Disorders Not yet recruiting NCT02850393
19 Assessment of Persistent Cognitive Impairment After Cure of Cushing's Disease Not yet recruiting NCT02603653

Search NIH Clinical Center for Dependent Personality Disorder

Cochrane evidence based reviews: dependent personality disorder

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Genetic Tests for Dependent Personality Disorder

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Anatomical Context for Dependent Personality Disorder

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Publications for Dependent Personality Disorder

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Articles related to Dependent Personality Disorder:

(show all 22)
id Title Authors Year
1
Relationship between alexithymia and dependent personality disorder: a dimensional analysis. ( 25529260 )
2015
2
Is dependent personality disorder associated with mild cognitive impairment and dementia in Central Africa? A result from the EPIDEMCA programme. ( 25177857 )
2014
3
Dependent personality disorder: a critical review. ( 24185092 )
2013
4
Illuminating a neglected clinical issue: societal costs of interpersonal dependency and dependent personality disorder. ( 22623345 )
2012
5
Alexithymia and dependent personality disorder. ( 22349651 )
2012
6
The heritability of avoidant and dependent personality disorder assessed by personal interview and questionnaire. ( 22486635 )
2012
7
Dependent personality disorder and physical abuse. ( 20537714 )
2011
8
Reconceptualizing personality pathology in DSM-5: limitations in evidence for eliminating dependent personality disorder and other DSM-IV syndromes. ( 21466252 )
2011
9
Pre-treatment predictors and in-treatment factors associated with change in avoidant and dependent personality disorder traits among patients with social phobia. ( 19630068 )
2010
10
Rethinking dependent personality disorder: comparing different human relatedness in cultural contexts. ( 19996716 )
2009
11
Dependent personality disorder: comparing an expert generated and empirically derived five-factor model personality disorder count. ( 18258728 )
2008
12
Dependent personality disorder. Threatened by self-reliance, they take shelter in submission. ( 17443985 )
2007
13
The quality of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition dependent personality disorder prototype. ( 17067868 )
2006
14
The dimensionality of dependent personality disorder. ( 15615670 )
2004
15
Dependent personality disorder as a marker of "battered husband syndrome": a case exemplar. ( 14733462 )
2003
16
Comorbidity of dependent personality disorder and separation anxiety disorder in addictive disorders and in healthy subjects. ( 12239442 )
2002
17
D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. ( 9345090 )
1997
18
Dependent personality disorder. Age, sex, and axis I comorbidity. ( 8551284 )
1996
19
The morbidity of DSM-III-R dependent personality disorder. ( 8551285 )
1996
20
Using the family history method to distinguish relatives of patients with dependent personality disorder from relatives of controls. ( 1798822 )
1991
21
Avoidant and dependent personality traits in relatives of patients with panic disorder, patients with dependent personality disorder, and normal controls. ( 1771212 )
1991
22
Comparisons of males and females with DSM-III dependent personality disorder. ( 2243898 )
1990
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Variations for Dependent Personality Disorder

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Expression for Dependent Personality Disorder

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Search GEO for disease gene expression data for Dependent Personality Disorder.
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Pathways for Dependent Personality Disorder

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Pathways related to Dependent Personality Disorder according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
superpathway of tryptophan utilization 1
Show member pathways
 11.68 CYP3A4 MAOA MAOB
2
Transcription_Role of VDR in regulation of genes involved in osteoporosis 21
11.02 CYP3A4 TNFSF11
3
Histidine metabolism 37
Show member pathways
 10.87 MAOA MAOB
4
Dopamine metabolism 1
10.3 MAOA MAOB
5
noradrenaline and adrenaline degradation 1
Show member pathways
 10.1 MAOA MAOB
6
putrescine degradation III 1
Show member pathways
 9.74 MAOA MAOB
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GO Terms for Dependent Personality Disorder

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Cellular components related to Dependent Personality Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 actin cytoskeleton GO:0015629 9.33 KNTC1 WASF1 WASF2
2 mitochondrial outer membrane GO:0005741 9.13 MAOA MAOB WASF1
3 SCAR complex GO:0031209 8.62 WASF1 WASF2

Biological processes related to Dependent Personality Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Rac protein signal transduction GO:0016601 9.26 WASF1 WASF2
2 neurotransmitter catabolic process GO:0042135 9.16 MAOA MAOB
3 dopamine catabolic process GO:0042420 8.96 MAOA MAOB
4 lamellipodium morphogenesis GO:0072673 8.62 WASF1 WASF2

Molecular functions related to Dependent Personality Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 primary amine oxidase activity GO:0008131 8.62 MAOA MAOB
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Sources for Dependent Personality Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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