Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: DRM006
MIFTS: 67

Dermatitis

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Dermatitis

About this section

MalaCards integrated aliases for Dermatitis:

Name: Dermatitis 12 51 41 14 69
Eczema 12 72 28 51 40 69 59
Inflammatory Dermatosis 69
Skin Inflammation 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


Sources

Summaries for Dermatitis

About this section
MedlinePlus : 40 Eczema is a term for several different types of skin swelling. Eczema is also called dermatitis. Most types cause dry, itchy skin and rashes on the face, inside the elbows and behind the knees, and on the hands and feet. Scratching the skin can cause it to turn red, and to swell and itch even more. Eczema is not contagious. The cause is not known. It is likely caused by both genetic and environmental factors. Eczema may get better or worse over time, but it is often a long-lasting disease. People who have it may also develop hay fever and asthma. The most common type of eczema is atopic dermatitis. It is most common in babies and children but adults can have it too. As children who have atopic dermatitis grow older, this problem may get better or go away. But sometimes the skin may stay dry and get irritated easily. Treatments may include medicines, skin creams, light therapy, and good skin care. You can prevent some types of eczema by avoiding Things that irritate your skin, such as certain soaps, fabrics, and lotions Stress Things you are allergic to, such as food, pollen, and animals NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Dermatitis, also known as eczema, is related to allergic contact dermatitis and contact dermatitis, and has symptoms including pruritus and exanthema. An important gene associated with Dermatitis is FLG (Filaggrin), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Menthol and Zinc have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin.

PubMed Health : 59
About eczema: Eczema is a common, chronic, non-infectious skin condition. The main symptom of this inflammatory disease is a very itchy rash. It often affects children. In many cases eczema gets better as the years go by, and it may go away for a while or disappear altogether. Acute flare-ups can really affect quality of life. The itching can be especially bad, making it difficult to concentrate and sleep well. Some people are embarrassed if their rash is visible to others. By taking good care of your skin, using medication and avoiding irritants and other things that can trigger the eczema, it is usually possible to relieve the symptoms at least enough to live a fairly normal life.Eczema is sometimes also called "atopic eczema" or "atopic dermatitis."

Wikipedia : 72 Dermatitis, also known as eczema, is a group of diseases that results in inflammation of the skin. These... more...

Sources

Related Diseases for Dermatitis

About this section

Diseases related to Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 699)
# Related Disease Score Top Affiliating Genes
1 allergic contact dermatitis 34.4 CCL17 FLG IL31 IL4
2 contact dermatitis 33.7 CCL17 CCL22 CCL27 FLG IL31 IL4
3 dermatitis, atopic 32.6 CCL11 CCL17 CCL22 CCL27 CMA1 FLG
4 egg allergy 32.5 FLG IGHE IL4
5 netherton syndrome 32.4 DSG1 FLG SPINK5
6 bullous pemphigoid 32.4 CCL11 CCL17 DSG1
7 onchocerciasis 32.4 CCL11 IL13 IL4
8 allergic rhinitis 32.3 CCL11 IGHE IL13 IL4
9 hyper ige syndrome 31.8 IGHE IL4
10 asthma 31.7 CCL11 CCL17 CCL22 FLG IGHE IL13
11 food allergy 30.9 FLG IL13 IL4
12 ige responsiveness, atopic 30.9 FLG IGHE IL13 IL4 SPINK5
13 allergic hypersensitivity disease 30.7 CCL11 CCL17 IGHE IL13 IL4
14 conjunctivitis 30.7 CCL11 IL13 IL4
15 rhinitis 30.6 CCL11 IGHE IL13 IL4
16 psoriasis 30.6 CCL17 CCL22 CCL27 FLG IL13 IL4
17 skin disease 30.5 CCL17 DSG1 FLG IL4 SPINK5
18 keratoconjunctivitis 30.3 CCL11 CCL17 IL13 IL4
19 allergic conjunctivitis 30.3 CCL11 IL13 IL4
20 atopic keratoconjunctivitis 30.3 CCL22 IGHE IL4
21 allergic asthma 30.2 CCL11 CCL17 IGHE IL13 IL4
22 schistosomiasis 30.1 IGHE IL13 IL4
23 lichen amyloidosis 30.1 IL31 IL31RA
24 peanut allergy 30.0 CCL22 FLG IGHE IL13
25 vernal keratoconjunctivitis 29.9 CCL11 IL13 IL4
26 blepharitis 29.8 CCL11 IL4
27 otitis media 29.8 CCL11 IGHE IL4
28 latex allergy 29.8 FLG IGHE IL13 IL4
29 blepharoconjunctivitis 29.7 CCL11 CMA1 IL4
30 strongyloidiasis 29.7 CCL11 IL13
31 hypereosinophilic syndrome 29.7 CCL11 CCL17 IGHE IL13
32 chronic conjunctivitis 29.3 CCL11 CMA1 IL13 IL4
33 dermatitis herpetiformis 12.4
34 irritant dermatitis 12.4
35 seborrheic dermatitis 12.4
36 seborrheic infantile dermatitis 12.3
37 cercarial dermatitis 12.3
38 dermatitis, atopic, 2 12.3
39 chronic actinic dermatitis 12.2
40 seborrhea-like dermatitis with psoriasiform elements 12.2
41 autoimmune progesterone dermatitis 12.2
42 contagious pustular dermatitis 12.2
43 dermatitis herpetiformis, familial 12.1
44 dermatitis, atopic, 3 12.1
45 interstitial granulomatous dermatitis with arthritis 12.1
46 immunodeficiency 11b with atopic dermatitis 12.1
47 dermatitis, atopic, 4 12.1
48 dermatitis, atopic, 5 12.1
49 dermatitis, atopic, 6 12.1
50 dermatitis, atopic, 7 12.1

Graphical network of the top 20 diseases related to Dermatitis:



Diseases related to Dermatitis
Sources

Symptoms & Phenotypes for Dermatitis

About this section

UMLS symptoms related to Dermatitis:


pruritus, exanthema

GenomeRNAi Phenotypes related to Dermatitis according to GeneCards Suite gene sharing:

25 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.58 MSMO1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.58 IL13
3 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.58 IL13
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.58 IL13
5 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.58 MSMO1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.58 MSMO1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.58 NACA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.58 MSMO1 NACA FAF2 IL13
9 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.58 MSMO1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.58 FAF2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.58 NACA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.58 IL13
13 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.58 MSMO1 FAF2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.58 NACA

MGI Mouse Phenotypes related to Dermatitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.32 CARD11 CCL11 CCL17 CCL22 CMA1 IL13
Sources

Drugs & Therapeutics for Dermatitis

About this section

PubMedHealth treatment related to Dermatitis: 59

Eczema is a chronic condition. Treatment cannot cure it, but regular skin care and medication can help to keep the itching and rash at bay. The main treatment options are:Basic treatment: Lipid-replenishing and moisturizing products (emollients) are generously applied to the skin at least twice a day to keep it from drying out. This can help relieve itching and protect the skin from germs and irritants.Special soaps,liquid cleansers and shampoos: Normal soaps and products like shampoo or shower gel contain various substances that can dry out your skin. Special cleansing products without these substances are available to get around this problem. But basic treatment with emollients can usually compensate for the loss of moisture caused by normal soaps.Steroid creams: Eczema flare-ups are usually treated with steroid creams because they can relieve the itching and inflammation. They are typically used only for acute symptoms. But they are sometimes used at regular intervals together with moisturizing skin care products (basic treatment): for example, as a "weekend treatment" where a steroid cream is applied on one or two days a week.Pimecrolimus and tacrolimus: Pimecrolimus and tacrolimus are two other medicines that can be used to treat eczema. They are not approved for use in children under the age of two years, though. These two medicines are also applied to the skin in a cream or ointment, and can be used if steroid products are not an option. This might be the case if steroid treatment is not tolerated or is ineffective. Pimecrolimus and tacrolimus may also be an option for long-term treatment of sensitive skin in the face and neck area. They can also be used on one or two days per week only, as described above.Other eczema treatment options include wet wraps, UV radiation and medications that suppress certain immune responses. Tablets containing these medicines are used if other treatments don't work, or if the eczema is very severe or affects large areas of skin. Because they have an effect throughout the entire body, they may have more extensive side effects than topical treatments.Allergy medications (antihistamines) are also commonly used to relieve itching. But research has now shown that they are not suitable for treating eczema, whether used as tablets or a cream.People often try out herbal products or dietary supplements, such as evening primrose oil, borage oil, vitamin B6, vitamin E and zinc. But research hasn't shown that these products are effective.Many other treatments such as laser therapies or hyposensitization have not yet been studied enough, so they are not recommended by medical associations.

Drugs for Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 539)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4,Phase 3,Phase 2 2216-51-5 16666
2
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2 7440-66-6 32051 23994
3
Zinc oxide Approved Phase 4,Phase 3,Phase 2 1314-13-2
4
Montelukast Approved Phase 4 158966-92-8 5281040
5
Ethanol Approved Phase 4,Phase 3,Phase 1 64-17-5 702
6
Petrolatum Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 8009-03-8
7 Titanium dioxide Approved Phase 4 13463-67-7
8
Bacitracin Approved, Vet_approved Phase 4,Phase 3,Phase 2 1405-87-4 10909430 439542
9
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 657311 5754
10 Parthenolide Approved, Investigational Phase 4,Phase 3,Phase 2 20554-84-1
11
Ciclopirox Approved, Investigational Phase 4,Phase 3 29342-05-0 2749
12
Isotretinoin Approved Phase 4,Phase 3 4759-48-2 5282379 5538
13
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
14
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
15
Clobetasol Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 25122-41-2, 25122-46-7 5311051 32798
16
Glycerol Approved, Investigational Phase 4,Phase 3 56-81-5 753
17
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
18
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 124-94-7 31307
19
Cetuximab Approved Phase 4,Phase 3,Phase 2 205923-56-4 56842117 2333
20
Desonide Approved, Investigational Phase 4,Phase 3 638-94-8 5311066
21
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 51-45-6, 75614-87-8 774
22
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
23
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
24
Povidone Approved Phase 4,Phase 3,Phase 2 9003-39-8
25
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 378-44-9 9782
26
Ephedrine Approved Phase 4,Phase 2 299-42-3 9294
27
Pseudoephedrine Approved Phase 4,Phase 2 90-82-4 7028
28
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137071-32-0 17753757 6447131
29
Fluocinonide Approved, Investigational Phase 4 356-12-7 9642
30
Cortisone acetate Approved, Investigational Phase 4,Phase 2 1950-04-4, 50-04-4 5745
31
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1 83881-51-0 2678
32
Levocetirizine Approved Phase 4,Phase 3,Phase 1 130018-77-8
33
Omalizumab Approved, Investigational Phase 4,Phase 2,Phase 1 242138-07-4
34
Ketoconazole Approved, Investigational Phase 4,Phase 3 65277-42-1 3823 47576
35
Desoximetasone Approved Phase 4 382-67-2 5311067
36
Mupirocin Approved, Investigational, Vet_approved Phase 4 12650-69-0 446596
37
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
38 Racepinephrine Approved Phase 4,Phase 2 329-65-7
39
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
40
Adapalene Approved Phase 4,Phase 2,Phase 1 106685-40-9 60164
41
Benzoyl peroxide Approved Phase 4 94-36-0 7187
42
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
43
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
44
Adalimumab Approved Phase 4,Phase 2 331731-18-1 16219006
45
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
46
Sorafenib Approved, Investigational Phase 4,Phase 1 284461-73-0 216239 406563
47
Alitretinoin Approved, Investigational Phase 4,Phase 3 5300-03-8 444795
48
Sorbitol Approved Phase 4 50-70-4 5780
49
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 5271565 637568
50
Dapsone Approved, Investigational Phase 4 80-08-0 2955

Interventional clinical trials:

(show top 50) (show all 1155)

# Name Status NCT ID Phase Drugs
1 Trial Comparing Calmoseptine Ointment and Desitin Diaper Rash Paste in Diaper Dermatitis in Neonates and Infants Unknown status NCT02716415 Phase 4 Calmoseptine Ointment;Destin Maximum Strength 40% Zinc
2 Does Treatment With Montelukast Improve Symptoms of Atopic Dermatitis in Children? Unknown status NCT02534467 Phase 4 Montelukast
3 Mometasone Furoate Cream Reduces Acute Radiation Dermatitis in Head and Neck Squamous Cell Carcinomas' Patients Unknown status NCT02495064 Phase 4 Mometasone Furoate Cream
4 Efficacy of KAM2904 Face Cream and KAM3008 Body Lotion Treatment in Children With Atopic Dermatitis (AD) Unknown status NCT01781663 Phase 4
5 Clinical Evaluation of T.R.U.E. Test Allergens in Children an Adolescents Unknown status NCT01797562 Phase 4 T.R.U.E. Test Panel 3.2
6 Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea Unknown status NCT01139749 Phase 4 oral isotretinoin;salicylic acid and ciclopirox olamine
7 Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation Unknown status NCT00779792 Phase 4 clobetasol;triamcinolone acetonide;tacrolimus;glycerol;vehicle ointment (paraffin oil/soft white paraffin)
8 Skin Changes in Head and Neck Cancer During Immuno-(Chemo-) And Radiotherapy With Erbitux® (HICARE) Unknown status NCT01553032 Phase 4 Erbitux®
9 Quaternium-15, Use Test Unknown status NCT00311454 Phase 4 T.R.U.E.Test
10 The Randomized Controlled Clinical Trial of Kushen Injection Unknown status NCT02346318 Phase 4 Compound Kushen Injection
11 Effect of Moisturizing Creams on Skin Barrier Function Unknown status NCT00771121 Phase 4 urea/lactic acid;Placebo
12 Effects of Pimecrolimus Cream 1% on the Molecular and Cellular Profile of Adult Male Patients With Atopic Dermatitis Completed NCT00117377 Phase 4 Pimecrolimus;Placebo
13 Efficacy and Tolerability of New Topical Formulations in Subjects With Atopic Dermatitis Completed NCT02732314 Phase 4 Investigational OTC Cream;0.05% Desonide Cream
14 A Study Evaluating the Efficacy of Fluocinonide Cream 0.1% (Vanos) in Subjects With Atopic Dermatitis Completed NCT01049243 Phase 4 Fluocinonide Cream 0.1%
15 Open Label Study of Long Term Treatment of Pediatric Treatment of Atopic Dermatitis With Pimecrolimus Cream 1% Within a Usual Clinical Setting Completed NCT00509990 Phase 4 Pimecrolimus
16 Comparison of Pimecrolimus Cream 1% Twice-Daily to Once-Daily Dosing in the Management of Atopic Dermatitis in Pediatric Subjects Completed NCT00139581 Phase 4 Pimecrolimus;Pimecrolimus
17 Adherence to Topical Hydrocortisone 17-butyrate 0.1% (Locoid®) Using Different Vehicles in Adults With Atopic Dermatitis Completed NCT00693693 Phase 4 hydrocortisone 17-butyrate 0.1% Cream preparation;hydrocortisone 17-butyrate 0.1% Ointment preparation;hydrocortisone 17-butyrate 0.1% Lipocream preparation
18 An Efficacy and Safety Study of Tacrolimus Ointment in Adult Participants With Atopic Dermatitis Completed NCT01828879 Phase 4 Tacrolimus
19 An Efficacy and Safety Study of Tacrolimus Ointment in Pediatric Participants With Atopic Dermatitis Completed NCT01782729 Phase 4 Tacrolimus
20 Study to Evaluate the Safety and Efficacy of Alefacept (Amevive) in Subjects With Moderate to Severe Atopic Dermatitis Completed NCT00832585 Phase 4 Alefacept
21 Efficacy Study of Montelukast in Atopic Dermatitis Induced by Food Allergens Completed NCT00557284 Phase 4 Montelukast;Placebo
22 A Comparison Study Between Protopic (Tacrolimus) Ointment and Elidel (Pimecrolimus) Cream in Treating Subjects With Atopic Dermatitis Completed NCT00666302 Phase 4 tacrolimus ointment;pimecrolimus cream
23 Epiceramâ„¢ Device Versus Mid-Strength Topical Steroid (Fluticasone Propionate 0.05%) for Treatment of Atopic Dermatitis Completed NCT00616538 Phase 4 Fluticasone Propionate 0.05%
24 Comparison Study Between Protopic (Tacrolimus Ointment) and Elidel (Pimecrolimus Cream) in Treating Pediatric Patients With Atopic Dermatitis Completed NCT00666159 Phase 4 tacrolimus ointment;pimecrolimus cream
25 Comparison Study Between Protopic (Tacrolimus Ointment) and Elidel (Pimecrolimus Cream) in Pediatric Patients With Mild Atopic Dermatitis Completed NCT00667160 Phase 4 tacrolimus ointment;pimecrolimus cream
26 A Clinical Study in Children and Adolescents With Mild to Moderate Atopic Dermatitis Completed NCT00568412 Phase 4 Elidel
27 Pimecrolimus Cream 1% (Elidel®) and Medicated Device Cream (EletoneTM) in the Treatment and Maintenance of Atopic Dermatitis. Completed NCT01177566 Phase 4 pimecrolimus
28 Measuring Adherence to Topical Therapy in Children With Atopic Dermatitis and the Impact of a Return Visit Completed NCT00654355 Phase 4 tacrolimus ointment
29 Study of the Safety and Efficacy of Tacrolimus Ointment in Treating Chronic Allergic Contact Dermatitis Completed NCT00667056 Phase 4 tacrolimus ointment;placebo ointment
30 Elidel-Study: Elidel in Patients With Atopic Dermatitis Completed NCT00180141 Phase 4 Elidel-Creme
31 Efficacy of Desonide (Desonatetm) Gel 0.05% in Younger and Older Subjects With Atopic Dermatitis Completed NCT00690833 Phase 4 topical desonide hydrogel 0.05%
32 Evaluation of Cetaphil Advanced Usage to Control Light to Moderate Atopic Dermatitis, in Attempt to Reduce the Necessity of Topic Corticoids Application Completed NCT01063218 Phase 4
33 Management of Pruritus With Xyzal in Atopic Dermatitis Completed NCT00884325 Phase 4 Levocetirizine dihydrochloride (Xyzal);placebo
34 Epiceram Versus Elidel for Treatment of Mild to Moderate Atopic Dermatitis Completed NCT00460083 Phase 4 Elidel(R) (pimecrolimus 1%)
35 Proactive Treatment of Tacrolimus Ointment for Adult Facial Seborrheic Dermatitis Completed NCT01591070 Phase 4 Tacrolimus;Tacrolimus
36 Pimecrolimus Cream 1% Plus Topical Corticosteroid in Patients (2-17 Years of Age) With Severe Atopic Dermatitis Completed NCT00121381 Phase 4 Pimecrolimus plus topical corticosteroid (TCS);Pimecrolimus vehicle (Placebo) plus topical corticosteroid (TCS)
37 Trial on Effectiveness Combined Probiotics in Atopic Dermatitis in Children Completed NCT02519556 Phase 4 Probiatop;Placebo
38 Analysis of the Quality of Life, the Clinical Effectiveness and Cost-effectiveness of a Novel Educational Programme in Patients With Psoriasis and Atopic Dermatitis Completed NCT01077882 Phase 4
39 Cetaphil Restoraderm Effect on Young Children With Atopic Dermatitis Completed NCT02589392 Phase 4
40 Ethanol-Free Clobetasol Propionate Foam 0.05% (Olux-E Foam) vs Vehicle Foam in the Treatment of Chronic Hand Dermatitis. Completed NCT01323673 Phase 4 clobetasol propionate 0.05%;Vehicle / Placebo
41 Locobase® REPAIR Used as an Adjunctive to Standard Therapy in Children With Moderate to Severe Atopic Dermatitis Completed NCT00673725 Phase 4 Locobase® REPAIR
42 Preventive Treatment of Tacrolimus Ointment in Children With Atopic Dermatitis Completed NCT01745159 Phase 4 tacrolimus
43 Efficacy and Safety of Pimecrolimus Cream 1% in Patients (2 to 11 Years Old) With Mild to Moderate Facial Atopic Dermatitis Completed NCT00130364 Phase 4 Pimecrolimus;Placebo
44 A Study to Investigate the Use of Hydrogel Vehicle in Maintaining the Skin Barrier in Persons With Atopic Dermatitis Completed NCT01065714 Phase 4 Hydrogel vehicle;Eucerin Lotion
45 Study to Determine the Effect of an Anti-IgE Agent on Inflammatory Cells in the Skin of Atopic Dermatitis Patients Completed NCT00822783 Phase 4 Omalizumab;Placebo
46 A Multi-Center Study of Short and Long-term Use of Protopic Ointment in Patients With Atopic Dermatitis Completed NCT00106496 Phase 4 Protopic;Corticosteroid;placebo
47 Combination Therapy for Atopic Dermatitis Completed NCT00119158 Phase 4 Combination of pimecrolimus and fluticasone;pimecrolimus
48 Comparison of the Efficacy and Safety of Two Topical Creams for Pediatric Atopic Dermatitis Completed NCT00828412 Phase 4 Desonide Cream 0.05%
49 STUDY TO ASSESS THE LONG-TERM SAFETY OF EXTINA (KETOCONAZOLE) FOAM, 2% Completed NCT00703846 Phase 4 Ketoconazole
50 Evaluating Treatment Resistant Dermatitis TaroIIR Completed NCT03050294 Phase 4 Desoximetasone 0.25% spray

Search NIH Clinical Center for Dermatitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: dermatitis

Sources

Genetic Tests for Dermatitis

About this section

Genetic tests related to Dermatitis:

# Genetic test Affiliating Genes
1 Eczema 28
Sources

Anatomical Context for Dermatitis

About this section

MalaCards organs/tissues related to Dermatitis:

38
Skin, Testes, T Cells, Colon, Neutrophil, Eye, Monocytes
Sources

Publications for Dermatitis

About this section

Articles related to Dermatitis:

(show top 50) (show all 5433)
# Title Authors Year
1
Conjunctivitis Occurring in Atopic Dermatitis Patients Treated with Dupilumab - Clinical Characteristics and Treatment. ( 29432961 )
2018
2
Drug survival and post-drug survival of first-line immunosuppressive treatments for atopic dermatitis: comparison between methotrexate and cyclosporine. ( 29444359 )
2018
3
A case of contact dermatitis and contact urticaria syndrome due to multiple allergens observed in a professional baseball player. ( 29395964 )
2018
4
Fecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study. ( 29393195 )
2018
5
Allergic contact dermatitis caused by hydroxyacetophenone in a face cream. ( 29341188 )
2018
6
Analysis of Bacterial and Fungal Nucleic Acid in Canine Sterile Granulomatous and Pyogranulomatous Dermatitis and Panniculitis. ( 29145794 )
2018
7
Allergic contact dermatitis resulting from cetyl PEG/PPG-10/1 dimethicone in a deodorant cream. ( 29430705 )
2018
8
Kumkum-induced allergic contact dermatitis: Are we missing the actual culprit? ( 29393081 )
2018
9
First report of allergic contact dermatitis caused by sorbitan caprylate. ( 29341184 )
2018
10
Case of engraftment syndrome appearing as scratch dermatitis. ( 28983967 )
2018
11
Increased interleukin-36I^ expression in skin and sera of patients with atopic dermatitis and mycosis fungoides/SAczary syndrome. ( 29314201 )
2018
12
Case of atopic dermatitis concurrent with idiopathic thrombocytopenic purpura, whose serum thymus and activation-regulated chemokine level remained undetectable. ( 29399856 )
2018
13
Textile contact dermatitis caused by octylisothiazolinone in compression stockings. ( 29399813 )
2018
14
IgE-expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy and atopic dermatitis. ( 29380876 )
2018
15
Post-exposure prevention of toxicodendron dermatitis with early forceful unidirectional washing. ( 29410167 )
2018
16
Chromium(III) release from chromium-tanned leather elicits allergic contact dermatitis: a use test study. ( 29322530 )
2018
17
Could conjunctivitis in dupilumab treated atopic dermatitis patients be caused by colonization with demodex and increased IL-17 levels? ( 29333603 )
2018
18
Allergic contact dermatitis caused by topical ketoconazole: a relevant issue? Review of ketoconazole-positive patch tests. ( 29430708 )
2018
19
Alopecia areata after dupilumab for atopic dermatitis. ( 29387767 )
2018
20
Signs of atopic dermatitis and contact dermatitis affected by distinct H2-haplotype in the NC/Nga genetic background. ( 29416104 )
2018
21
Lymphocyte surface markers and cytokines are suitable for detection and potency assessment of skin-sensitizing chemicals in an in vitro model of allergic contact dermatitis: the LCSA-ly. ( 29380012 )
2018
22
A cross-sectional study of YouTube videos about atopic dermatitis. ( 29447681 )
2018
23
Could conjunctivitis in dupilumab treated atopic dermatitis patients be caused by colonization with Demodex and increased IL-17 levels? Reply from authors. ( 29336016 )
2018
24
Involvement of the Negative Feedback of IL-33 Signaling in the Anti-Inflammatory Effect of Electro-acupuncture on Allergic Contact Dermatitis via Targeting MicroRNA-155 in Mast Cells. ( 29404871 )
2018
25
Independent risk factors for the development of incontinence-associated dermatitis (category 2) in critically ill patients with fecal incontinence: A cross-sectional observational study in 48 ICU units. ( 29428583 )
2018
26
The Role and Diagnosis of Allergic Contact Dermatitis in Patients with Atopic Dermatitis. ( 29305764 )
2018
27
Is atopic dermatitis associated with obesity? A systematic review of observational studies. ( 29444366 )
2018
28
Lymphomatoid contact dermatitis caused by limonene hydroperoxides confirmed by an exposure provocation test with the involved personal hygiene products. ( 29430707 )
2018
29
Allergic contact dermatitis caused by OlanedineAr (olanexidine gluconate), a new antiseptic. ( 29341182 )
2018
30
Allergic contact dermatitis caused by Solvent Orange 60 in spectacle frames in Japan. ( 29265444 )
2018
31
Palisading neutrophilic and granulomatous dermatitis as a presentation of Hodgkin lymphoma: A case and review. ( 29226345 )
2018
32
Impact of Food Allergy on the Growth of Children with Moderate-Severe Atopic Dermatitis. ( 29378286 )
2018
33
Impact of dupilumab on health-related quality of life in patients with atopic dermatitis. ( 29441557 )
2018
34
Scalp Seborrheic Dermatitis and Dandruff Therapy Using a Herbal and Zinc Pyrithione-based Therapy of Shampoo and Scalp Lotion. ( 29410727 )
2018
35
Cytokine Targeted Therapeutics forA Alopecia Areata: Lessons fromA Atopic Dermatitis and OtherA Inflammatory Skin Diseases. ( 29273110 )
2018
36
New mechanism underlying IL-31-induced atopic dermatitis. ( 29427643 )
2018
37
Allergic contact dermatitis caused by triethylenetetramine: the glue is the clue. ( 29392782 )
2018
38
A private case of allergic contact dermatitis. ( 29341989 )
2018
39
JAK inhibitors appear to have a bright future in the treatment of atopic dermatitis. ( 29441552 )
2018
40
A novel case of a brush with discomfort: allergic contact dermatitis caused by mercaptobenzothiazole in rubber components of a toothbrush. ( 29446120 )
2018
41
Expression of Elafin in Dermatitis Herpetiformis. ( 29293478 )
2018
42
Enolase-1 expression in the stratum corneum is elevated with parakeratosis of atopic dermatitis and disrupts the cellular tight junction barrier in keratinocytes. ( 29430682 )
2018
43
Associations of TAP1 genetic polymorphisms with atopic diseases: asthma, rhinitis and dermatitis. ( 29416713 )
2018
44
Occupational allergic contact dermatitis caused by antibiotics in healthcare workersA -A relationship with non-immediate drug eruptions. ( 29399806 )
2018
45
Uncommon filaggrin variants are associated with persistent atopic dermatitis in African Americans. ( 29428354 )
2018
46
Diagnostic Delay in Dermatitis Herpetiformis in a High-prevalence Area. ( 29048096 )
2018
47
Non-occupational allergic contact dermatitis caused by long-lasting nail polish kits for home use: 'the tip of the iceberg'. ( 29327355 )
2018
48
Possible role of regional variation in allergic contact dermatitis: case report. ( 29430710 )
2018
49
Boat builders' occupational contact dermatitis - 11-year data from the Finnish register of occupational diseases. ( 29383726 )
2018
50
Systemic allergic dermatitis caused by sodium metabisulfite in rectal enemas. ( 29446100 )
2018
Sources

Variations for Dermatitis

About this section
Sources

Expression for Dermatitis

About this section
Search GEO for disease gene expression data for Dermatitis.
Sources

Pathways for Dermatitis

About this section

Pathways related to Dermatitis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 62
Show member pathways
 13.85 CARD11 CCL11 CCL22 DSG1 FAF2 IGHE
2
Cytokine Signaling in Immune system 62
Show member pathways
 13.15 CCL11 CCL22 IGHE IL13 IL31 IL31RA
3
IL-17 Family Signaling Pathways 61
Show member pathways
 12.11 CCL11 CCL17 IL13 IL4
4
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 61
Show member pathways
 11.73 CCL11 CCL17 CCL22 CCL27
5
Interleukin-4 and 13 signaling 62
11.61 CCL11 CCL22 IGHE IL13 IL4
6
IL4-mediated signaling events 1
11.42 CCL11 CCL17 IGHE IL4
7
Lung fibrosis 1
11.36 CCL11 CMA1 IL13 IL4
8
Interleukin-10 signaling 62
11.32 CCL22 IL13 IL4
9
G-protein signaling_Rap2B regulation pathway 21
10.78 CCL11 CCL17 CCL22 CCL27 IL13 IL4
10
Th2 Differentiation Pathway 61
10.76 CCL11 CCL17 CCL22 IL13 IL31 IL4
11
G-protein signaling_RhoB regulation pathway 21
10.66 CCL11 CCL17 CCL22 CCL27 IL13 IL4
12
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 61
10.57 IL13 IL4
Sources

GO Terms for Dermatitis

About this section

Cellular components related to Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.36 CCL11 CCL17 CCL22 CCL27 CMA1 FAF2

Biological processes related to Dermatitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.86 CCL17 CCL22 CCL27 IL13
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 CCL11 CCL17 CCL22 NOD2
3 cellular response to tumor necrosis factor GO:0071356 9.74 CCL11 CCL17 CCL22
4 cornification GO:0070268 9.72 DSG1 FLG SPINK5
5 cellular response to interferon-gamma GO:0071346 9.7 CCL11 CCL17 CCL22
6 cellular response to interleukin-1 GO:0071347 9.69 CCL11 CCL17 CCL22
7 chemokine-mediated signaling pathway GO:0070098 9.67 CCL11 CCL17 CCL22
8 neutrophil chemotaxis GO:0030593 9.65 CCL11 CCL17 CCL22
9 monocyte chemotaxis GO:0002548 9.61 CCL11 CCL17 CCL22
10 positive regulation of B cell proliferation GO:0030890 9.58 CARD11 IL13 IL4
11 chemotaxis GO:0006935 9.55 CCL11 CCL17 CCL22 CCL27 IL4
12 regulation of T cell differentiation GO:0045580 9.54 CARD11 SPINK5
13 immune response GO:0006955 9.5 CCL11 CCL17 CCL22 CCL27 IGHE IL13
14 lymphocyte chemotaxis GO:0048247 9.43 CCL11 CCL17 CCL22
15 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
16 T-helper 2 cell cytokine production GO:0035745 9.32 IL31RA IL4
17 regulation of receptor activity GO:0010469 9.17 CCL11 CCL17 CCL22 CCL27 IL13 IL31

Molecular functions related to Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CCR chemokine receptor binding GO:0048020 9.32 CCL17 CCL22
2 CARD domain binding GO:0050700 9.26 CARD11 NOD2
3 chemokine activity GO:0008009 9.26 CCL11 CCL17 CCL22 CCL27
4 CCR3 chemokine receptor binding GO:0031728 9.16 CCL11 CCL27
5 cytokine activity GO:0005125 9.1 CCL11 CCL17 CCL22 IL13 IL31 IL4
Sources

Sources for Dermatitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....