MCID: DRM006
MIFTS: 69

Dermatitis malady

Skin diseases category
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Summaries for Dermatitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Dermatitis (from Greek ????? derma \"skin\" and -???? -itis \"inflammation\") or eczema (Greek: ??????... more...

MalaCards: Dermatitis, also known as other chronic dermatitis due to solar radiation, is related to contact dermatitis and atopic dermatitis. An important gene associated with Dermatitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are OX40 Pathway and Cytokines and Inflammatory Response. The drugs clobetasol and cod liver oil and the compounds salmeterol and histamine dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Dermatitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

dermatitis 8 10 45 62
other chronic dermatitis due to solar radiation 8
other dermatitis due to solar radiation 8
skin inflammation nos 8
dermatitis, nos 8
dermatitis nos 8


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Disease Ontology8 DOID:2723
MeSH35 D003872
NCIt40 C2983
ICD1025 L30

Related Diseases for Dermatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 610)
idRelated DiseaseScoreTop Affiliating Genes
1contact dermatitis32.0FLG
2atopic dermatitis31.8IGHE, CCL27, HRH1, KLK7, IL13, IL5
3allergic contact dermatitis31.7FLG, CCL27, IL5, CXCR3, CCR4
4psoriasis31.0CCR4, FLG, IL5, CCL11, KLK7, CXCR3
5asthma31.0IL13, CCL11
6eczema herpeticum30.8IGHE
7atopy30.7FLG, CXCR3, IGHE, IL13, CCL11, IL5
8skin disease30.7IGHE, CXCR3, CCL11, CCL27, IL13, KLK7
9food allergy30.6IL13, IL5, CCL11, IGHE
10bullous pemphigoid30.6CCL11, IL5, FLG, IGHE, IL13
11cutaneous t cell lymphoma30.6CXCR3, IL5, CCR4
12lichen planus30.5CXCR3, FLG
13folliculitis30.5CCL11
14conjunctivitis30.4HRH1, IGHE
15eosinophilia30.4CCR4, CCL11, IL5, CCL27, IL13, IGHE
16rheumatoid arthritis30.4CCR4, CXCR3, FLG, CCL27, IL13, HRH1
17mycosis fungoides30.4CXCR3, CCL27, IL5, CCR4
18keratoconjunctivitis30.3IL5, CCL11, IL13
19egg allergy30.3IL5, IGHE
20rhinitis30.3IL13, CCL11, IL5, IGHE, HRH1
21netherton syndrome30.2IGHE, KLK7
22sarcoidosis30.1CCR4, IL13, CCL11, CXCR3
23cutaneous leishmaniasis30.1IL5, IL13
24bronchitis30.1CCL11, IL5, IGHE
25allergic asthma30.1IL13, CCL11, FLG, CCR4, HRH1, IL5
26angioedema30.1HRH1, IGHE, IL5
27schistosomiasis30.0IL13, IGHE, IL5
28leishmaniasis30.0IL5, IL13
29allergic rhinitis30.0HRH1, IGHE, CCL11, IL5, IL13
30eosinophilic gastroenteritis29.9CCL11, IGHE, IL5
31allergic conjunctivitis29.9IL5, IGHE, IL13, HRH1, CCL11
32strongyloidiasis29.7IL5, IGHE
33allergic bronchopulmonary aspergillosis29.7IL5, IGHE
34hypereosinophilic syndrome29.7IL5, CCL11, IGHE
35uveitis29.7CCL11, CCR4, CXCR3
36otitis media29.7IGHE, CCL11
37respiratory failure29.7CCL11, IL13, IGHE
38pneumonia29.7CCL11, IL13, IL5, HRH1
39helminthiasis29.7IGHE, IL5, IL13
40mastocytosis29.7IL5, IL13, IGHE
41vernal keratoconjunctivitis29.6IGHE, CCL11, CXCR3, IL5, IL13
42ipex syndrome29.6CCL27, CXCR3, CCL11, CCR4, IGHE
43multiple sclerosis29.6CXCR3, IL5, CCL27, CCL11, CCR4, IL13
44dermatitis herpetiformis11.1
45exfoliative dermatitis10.9
46occupational dermatitis10.9
47granulomatous dermatitis10.8
48chronic actinic dermatitis10.8
49irritant dermatitis10.8
50cercarial dermatitis10.6

Graphical network of the top 20 diseases related to Dermatitis:



Diseases related to dermatitis

Symptoms for Dermatitis

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Drugs & Therapeutics for Dermatitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Dermatitis

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Anatomical Context for Dermatitis

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Sources:
33MalaCards
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MalaCards organs/tissues related to Dermatitis:

33
Skin, T cells, Testes, Monocytes, Liver, Colon, Breast, Thyroid, Thymus, Endothelial, B cells, Bone, Eye, Lung, Small intestine, Whole blood, Heart, Tongue, Myeloid, Tonsil, Pituitary, Spinal cord, Pancreatic islet, Appendix, Lymph node, Brain, Kidney, Nk cells, Bone marrow

Animal Models for Dermatitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Dermatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.6FLG, CXCR3, CCR4, CCL11, IL5, IL13
2MP:00053878.1HRH1, IGHE, FLG, ADH5, CXCR3, CCR4

Publications for Dermatitis

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Sources:
52PubMed
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Articles related to Dermatitis:

(show top 50)    (show all 4400)
idTitleAuthorsYear
1
Human I^-defensin-2 as a marker for disease severity and skin barrier properties in atopic dermatitis. (23647067)
2013
2
Inhibitory effects of Juglans mandshurica leaf on allergic dermatitis-like skin lesions-induced by 2,4-dinitrochlorobenzene in mice. (24252297)
2013
3
IL-17 expression in dermatitis herpetiformis and bullous pemphigoid. (23970818)
2013
4
Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model. (23149290)
2013
5
Serum visfatin levels in patients with atopic dermatitis and cutaneous T-cell lymphoma. (24001451)
2013
6
Laser Recall Dermatitis. (24336981)
2013
7
Allergic contact dermatitis due to epsilon-aminocaproic acid: a case report and mini-review of the published work. (23398202)
2013
8
Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice. (23918359)
2013
9
A field trial of infrared thermography as a non-invasive diagnostic tool for early detection of digital dermatitis in dairy cows. (24389042)
2013
10
Allergic contact dermatitis caused by Hedera helix arborescens and not by Hedera helix L. (22568849)
2012
11
Effect of bathing on atopic dermatitis during the summer season. (23130333)
2012
12
Impact of interactive web-based education with mobile and email-based support of general practitioners on treatment and referral patterns of patients with atopic dermatitis: randomized controlled trial. (23249479)
2012
13
Management of dermatitis herpetiformis. (22560140)
2012
14
Interstitial granulomatous dermatitis? An unusual presentation in the mucosa and periungual skin. (21352283)
2011
15
Allergic contact dermatitis following ocular use of corticosteroids. (21265627)
2011
16
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. (21920128)
2011
17
Kaposi's sarcoma in an atopic dermatitis patient: a case report and a review of literature. (21385206)
2011
18
Systemic allergic contact dermatitis to black cumin essential oil expressing as generalized erythema multiforme. (21524993)
2011
19
Allergic contact dermatitis from N,N-methylenebismorpholine in a cutting oil. (20920419)
2010
20
In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. (20805398)
2010
21
Number of flocks on the same litter and carcase condemnations due to cellulitis, arthritis and contact foot-pad dermatitis in broilers. (21058060)
2010
22
A rare case of allergic contact dermatitis from silver nitrate in a widely used special patch test marker. (19706054)
2009
23
Generalized erythema multiforme after localized allergic dermatitis from dark henna tattoo. (19689544)
2009
24
Contact irritant dermatitis from insect secretions: report of 74 cases in a military unit in Eritrea. (19731793)
2009
25
Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3. (18538383)
2008
26
Bartonella-associated meningoradiculoneuritis and dermatitis or panniculitis in 3 dogs. (18466250)
2008
27
Occupational dermatitis in a hairdresser. (17717371)
2007
28
Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. (15944307)
2005
29
Inflammatory mediators in patients with atopic dermatitis after treatment with transfer factor]. (15491080)
2004
30
Effect of staphylococcal enterotoxin B on specific antibody production in children with atopic dermatitis. (12635580)
2003
31
Soluble E-selectin correlates with disease activity in cyclosporin A-treated patients with atopic dermatitis. (10195358)
1999
32
Tissue transglutaminase antibodies in dermatitis herpetiformis. (10490368)
1999
33
Acute inflammatory demyelinating polyradiculoneuropathy associated with hyperIgEemia and atopic dermatitis. (9562273)
1998
34
Meloxicam in acute UV dermatitis--a pilot study. (9826888)
1998
35
Occupational dermatitis due to formaldehyde in newspaper. (9330824)
1997
36
Resolution of exfoliative dermatitis and Malassezia pachydermatis overgrowth in a cat after surgical thymoma resection. (9358405)
1997
37
Chronic actinic dermatitis. An immunohistochemical study of its T-cell antigenic profile, with comparison to cutaneous T-cell lymphoma. (7802165)
1994
38
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
39
Systemic interferon gamma treatment in severe atopic dermatitis. (8315079)
1993
40
Photosensitivity dermatitis and actinic reticuloid syndrome (chronic actinic dermatitis). (2203443)
1990
41
Manic depression induced by dapsone in patient with dermatitis herpetiformis. (2510873)
1989
42
Occupational dermatitis to Ampholyt G in hospital personnel. (6222878)
1983
43
Video computer terminals and occupational dermatitis. (6458886)
1981
44
Cercarial dermatitis. (4412365)
1974
45
Exfoliative dermatitis and generalized erythroderma. (4257634)
1969
46
Hypothermia in patients with exfoliative dermatitis. (13754513)
1960
47
Allergic occupational dermatitis. (13336265)
1956
48
Exfoliative dermatitis after undecylenic acid therapy for psoriasis. (14774148)
1950
49
Exfoliative dermatitis; classification, diagnosis and treatment. (20252104)
1947
50
Exfoliative dermatitis following penicillin therapy. (20999603)
1946

Variations for Dermatitis

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Expression for genes affiliated with Dermatitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dermatitis

Search GEO for disease gene expression data for Dermatitis.

Pathways for genes affiliated with Dermatitis

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 54R&D Systems, 30KEGG, 55Reactome
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Pathways related to Dermatitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL13, IL5
210.1IL5, IL13
310.1IL13, IL5
49.7IL5, CCL11, IGHE
5
Show member pathways
9.4CXCR3, CCR4, CCL11, CCL27
6
Show member pathways
9.4CCL27, CCL11, CCR4, CXCR3
7
Show member pathways
9.4CCL27, CCL11, CCR4, CXCR3
8
Show member pathways
9.2CXCR3, CCR4, CCL11, CCL27, HRH1
9
Show member pathways
9.0CXCR3, CCR4, CCL11, CCL27, IL5, IL13
10
Show member pathways
9.0IL5, CCL27, CCL11, CCR4, CXCR3, IL13
11
Show member pathways
9.0CXCR3, CCR4, CCL11, CCL27, IL5, IL13
12
Show member pathways
8.8NACA, CXCR3, CCR4, CCL11, CCL27, IL5

Compounds for genes affiliated with Dermatitis

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Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Dermatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1salmeterol45 51 29 1113.2IL5, CCL11, IL13
2histamine dihydrochloride6110.2DHX8, DHX34, HRH1
32-pyridylethylamine dihydrochloride6110.2HRH1, DHX8, DHX34
4mepyramine maleate6110.2DHX34, DHX8, HRH1
5clemastine fumarate6110.2DHX8, HRH1, DHX34
6ltc44510.1CCL11, IL13, IL5
7unicap4510.1IGHE, IL5, CCL11
8ltd44510.1HRH1, IL5, IL13
9astemizole45 61 29 1113.1HRH1, DHX8, DHX34
10groalpha4510.1IL13, CCL11, CXCR3
11omalizumab45 1111.1IL5, IL13, IGHE
12trimellitic anhydride4510.1IGHE, IL13
13anti-histamine4510.1CCL11, IGHE, HRH1
14nickel45 2411.1IL13, FLG, IL5
15oxatomide4510.1HRH1, IL5, IGHE
16ovomucoid4510.1IGHE, IL13, IL5
17praziquantel45 1111.0IL5, IGHE, IL13
18nedocromil sodium4510.0IGHE, IL5, HRH1
19desloratadine45 1111.0IGHE, IL13, HRH1
20methyltetrahydrophthalic anhydride4510.0IL13, IGHE
21penicillin4510.0IGHE, IL5, IL13
22sodium cromoglycate459.9HRH1, CCL11, IL5, IGHE
23cetirizine45 29 24 1112.9CCL11, IGHE, HRH1, IL5
24montelukast45 51 29 1112.9IL5, IL13, CCL11, IGHE
25ketotifen45 1110.9IGHE, HRH1, IL5, CCL11
26budesonide45 51 1111.9CCL11, IL13, IGHE, IL5
27azelastine45 1110.9IL5, HRH1, IGHE
28salbutamol45 51 29 24 1113.9CCL11, IGHE, IL13, IL5
29fluticasone propionate45 51 61 1112.9IL13, IGHE, IL5, CCL11
30pgd2459.9IL5, CCL11, IL13, IGHE
31methacholine45 51 1111.9IL13, CCL11, IL5, IGHE
32tacrolimus45 51 1111.9HRH1, IL13, CCL11, CXCR3, IL5
33fmlp459.7CCL11, IL13, CXCR3, IL5
34hydrocortisone45 3 61 1112.7IGHE, CXCR3, IL5, IL13
35endotoxin459.7CXCR3, HRH1, CCL11, IL13
36ccl345 2910.6CXCR3, CCR4, CCL11, CCL27, IL13
37ccl445 2910.6IL13, CCL27, CCR4, CXCR3, CCL11
38prednisolone45 29 1111.6CCL11, IL5, IL13, IGHE, CCR4
39indomethacin45 29 61 1112.6HRH1, IGHE, CCL11, IL5, IL13
40histamine45 29 2411.5IGHE, HRH1, IL13, CXCR3, IL5, CCL11
41pge2459.5HRH1, CXCR3, CCL27, IL5, CCL11, IL13
42cyclosporin a45 29 6111.4IL13, HRH1, IGHE, IL5, CCL11
43isoproterenol45 1110.4IL13, IL5, HRH1, IGHE
44rantes459.2IL13, IL5, CCL11, CCR4, CXCR3, HRH1
45arginine459.2IGHE, IL13, IL5, DHX8, CXCR3, ADH5
46dexamethasone45 51 29 1112.1CCL27, CXCR3, IGHE, IL13, HRH1, IL5
47tarc459.1CCL27, IL13, IL5, CCR4, CXCR3, IGHE
48nitric oxide45 24 1111.1FLG, HRH1, CCL11, IL13, CXCR3, ADH5
49retinoic acid45 2410.0KLK7, ADH5, IL13, IL5, CCL11, CCR4
50allergens459.0IL5, CCL27, CCL11, IL13, CXCR3, HRH1

GO Terms for genes affiliated with Dermatitis

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16Gene Ontology
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Cellular components related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.7IL13, CCR4, CXCR3
2extracellular regionGO:0055768.7KLK7, IL13, IL5, CCL27, CCL11, IGHE

Biological processes related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.0HRH1, CCL11
2response to radiationGO:00931410.0CCL11, CCR4
3positive regulation of release of sequestered calcium ion into cytosolGO:0512819.8IL13, CXCR3
4chemotaxisGO:0069359.4CXCR3, CCR4, CCL11, CCL27
5inflammatory responseGO:0069549.3HRH1, IL13, IL5, CCL11, CCR4, CXCR3
6immune responseGO:0069558.9IGHE, CCR4, CCL11, CCL27, IL5, IL13

Molecular functions related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.9CCR4, CXCR3

Products for genes affiliated with Dermatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dermatitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet