MCID: DRM006
MIFTS: 68

Dermatitis malady

Skin diseases category

Summaries for Dermatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Dermatitis (from Greek δέρμα derma \"skin\" and -ῖτις -itis \"inflammation\") or eczema... more...

MalaCards: Dermatitis, also known as other chronic dermatitis due to solar radiation, is related to atopic dermatitis and contact dermatitis. An important gene associated with Dermatitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The drugs clobetasol and cod liver oil and the compounds allergens and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes.

Aliases & Classifications for Dermatitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

dermatitis 8 10 44 60
other chronic dermatitis due to solar radiation 8
other dermatitis due to solar radiation 8
skin inflammation nos 8
dermatitis, nos 8
dermatitis nos 8


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Disease Ontology8 DOID:2723
NCIt39 C2983
MeSH34 D003872
ICD1025 L30

Related Diseases for Dermatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 550)
idRelated DiseaseScoreTop Affiliating Genes
1atopic dermatitis32.0KLK7, CCL11, CCR4, CCL27, FLG, IGHE
2contact dermatitis31.8FLG
3allergic contact dermatitis31.6CCL27
4psoriasis31.1KLK7, CCL11, CCR4, CCL27, FLG, CXCR3
5skin disease30.8KLK7, CCL11, CCL27, FLG, IGHE, CXCR3
6asthma30.8IL5, IGHE
7arthritis30.7CXCR3, FLG
8eczema herpeticum30.6IGHE
9food allergy30.5CCL11, IGHE, IL5
10urticaria30.5HRH1, IGHE
11bullous pemphigoid30.5CCL11, FLG, IGHE, IL5
12cutaneous t cell lymphoma30.4CCR4, CXCR3, IL5
13rheumatoid arthritis30.4CCL11, CCR4, CCL27, FLG, CXCR3, HRH1
14eosinophilia30.4CCL11, CCR4, CCL27, IGHE, IL5
15allergic asthma30.3CCL11, CCR4, FLG, IGHE, IL5, HRH1
16mycosis fungoides30.3IL5, CXCR3, CCL27, CCR4
17folliculitis30.2CCL11
18rhinitis30.2HRH1, IL5, IGHE, CCL11
19conjunctivitis30.2HRH1, IGHE
20keratoconjunctivitis30.2IL5, CCL11
21egg allergy30.1IGHE, IL5
22allergic rhinitis30.1CCL11, CCR4, FLG, IGHE, CXCR3, IL5
23sarcoidosis30.0CXCR3, CCR4, CCL11
24netherton syndrome30.0IGHE, KLK7
25allergic conjunctivitis29.9CCL11, IGHE, IL5, HRH1
26bronchitis29.9CCL11, IGHE, IL5
27angioedema29.9HRH1, IL5, IGHE
28eosinophilic gastroenteritis29.8CCL11, IGHE, IL5
29onchocerciasis29.8IL5
30ipex syndrome29.5CCL11, CCR4, CCL27, IGHE, CXCR3
31uveitis29.5CCL11, CCR4, CXCR3
32pulmonary eosinophilia29.5IL5, IGHE, CCL11
33pneumonia29.5HRH1, IL5, CCL11
34strongyloidiasis29.5IL5, IGHE
35otitis media29.5CCL11, IGHE
36allergic bronchopulmonary aspergillosis29.5IL5, IGHE
37churg-strauss syndrome29.5IL5
38malaria29.5HRH1
39tuberculosis29.5CXCR3, CCR4
40dermatitis herpetiformis11.1
41occupational dermatitis11.0
42irritant dermatitis10.8
43granulomatous dermatitis10.8
44cercarial dermatitis10.6
45contagious pustular dermatitis10.5
46erythema multiforme10.5
47seborrheic infantile dermatitis10.5
48celiac disease10.4
49lupus erythematosus10.4
50photoallergic dermatitis10.4

Graphical network of the top 20 diseases related to Dermatitis:



Diseases related to dermatitis

Clinical Features for Dermatitis

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Drugs & Therapeutics for Dermatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Dermatitis

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Anatomical Context for Dermatitis

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32MalaCards
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MalaCards organs/tissues related to Dermatitis:

32
Skin, T cells, Testes, Monocytes, Liver, Colon, Thyroid, Breast, Thymus, Endothelial, B cells, Bone, Eye, Lung, Small intestine, Whole blood, Heart, Tongue, Myeloid, Tonsil, Pituitary, Spinal cord, Pancreatic islet, Appendix, Lymph node, Brain, Kidney, Nk cells, Bone marrow

Animal Models for Dermatitis or affiliated genes

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Publications for Dermatitis

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Sources:
50PubMed
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Articles related to Dermatitis:

(show top 50)    (show all 4446)
idTitleAuthorsYear
1
The effect of topical virgin coconut oil on SCORAD index, transepidermal water loss, and skin capacitance in mild to moderate pediatric atopic dermatitis: a randomized, double-blind, clinical trial. (24320105)
2014
2
Future treatment options for atopic dermatitis - Small molecules and beyond. (24360854)
2014
3
Severe allergic dermatitis after closure of foramen ovale with Amplatzer occluder. (23992730)
2013
4
Contact dermatitis due to methylchloroisothiazolinone/methylisothiazolinone (Kathon CG) as a contaminant in the manufacturing process of a cream. (22819363)
2013
5
Two-year follow-up survey of patients with allergic contact dermatitis from an occupational cohort. Is the prognosis dependent on the omnipresence of the allergen? (24359102)
2013
6
Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. (23331679)
2013
7
IL1A-889 C/T gene polymorphism in irritant contact dermatitis. (22364598)
2013
8
Linoleoyl ethanolamide reduces lipopolysaccharide-induced inflammation in macrophages and ameliorates 2,4-dinitrofluorobenzene-induced contact dermatitis in mice. (23201070)
2013
9
A case of allergic contact dermatitis caused by fructo oligosaccharide. (22233475)
2012
10
IL-31 significantly correlates with disease activity and Th2 cytokine levels in children with atopic dermatitis. (22509760)
2012
11
Workers with occupational contact dermatitis: workplace characteristics and prevention practices. (22837331)
2012
12
A case of false-negative monochromator phototesting in a patient with chronic actinic dermatitis taking prednisolone. (22250731)
2012
13
Neuroimmunological Mechanism of Pruritus in Atopic Dermatitis Focused on the Role of Serotonin. (24009842)
2012
14
Occupational contact dermatitis in manual cloud seeding operations. (21633757)
2011
15
Use of ciclosporin in a dog with canine juvenile sterile granulomatous dermatitis and lymphadenitis. (21251099)
2011
16
Pigmented contact dermatitis due to therapeutic sensitizer as complication of contact immunotherapy in alopecia areata. (20860739)
2010
17
Allergic contact dermatitis due to external bone lengthener. (19691756)
2009
18
Prevalent and rare mutations in the gene encoding filaggrin in Japanese patients with ichthyosis vulgaris and atopic dermatitis. (19037238)
2009
19
Diffuse xanthogranulomatous dermatitis and systemic Langerhans cell histiocytosis: A novel case that demonstrates bridging between non-Langerhans cell histiocytosis and Langerhans cell histiocytosis. (19022530)
2009
20
A Korean experience with chronic actinic dermatitis during an 18-year period: meteorological and photoimmunological aspects. (19906162)
2009
21
Palisaded neutrophilic granulomatous dermatitis associated with systemic lupus erythematosus presenting with the burning rope sign. (19577332)
2009
22
Allergic contact dermatitis to ethylene oxide. (19659965)
2009
23
Analysis of variation in the IL7RA and IL2RA genes in atopic dermatitis. (19523791)
2009
24
Tertiary individual prevention of occupational skin diseases: a decade's experience with recalcitrant occupational dermatitis. (18239930)
2008
25
Sensitization in early age to food allergens in children with atopic dermatitis. (17338897)
2007
26
Atopic dermatitis and transient hypogammaglobulinemia of infancy improved simultaneously. (17532847)
2007
27
Photoallergic dermatitis induced by diltiazem. (17244089)
2007
28
Atypical dermatitis herpetiformis: a Japanese case that presented with initial lesions mimicking prurigo pigmentosa. (16487118)
2006
29
Human arylamine N-acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis. (16533241)
2006
30
Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic dermatitis. (17121585)
2006
31
Macrophage-derived chemokine (MDC)/CCL22 produced by monocyte derived dendritic cells reflects the disease activity in patients with atopic dermatitis. (17008059)
2006
32
SAPHO osteomyelitis and sarcoid dermatitis in a patient with DiGeorge syndrome. (16491384)
2006
33
Lack of association of the G protein-coupled receptor for asthma susceptibility gene with atopic dermatitis. (15990798)
2005
34
Role of immunoglobulin E sensitization in eczema, previously referred to as atopic dermatitis. (20476939)
2005
35
Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life. (15305939)
2004
36
Interstitial granulomatous drug reaction with a histological pattern of interstitial granulomatous dermatitis. (11481519)
2001
37
Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES. (10640782)
2000
38
Similar IL-5, IL-3, and GM-CSF syntheses by eosinophils in the jejunal mucosa of patients with celiac disease and dermatitis herpetiformis. (9683545)
1998
39
Clinical, pathologic, and immunologic features of human T-lymphotrophic virus type I-associated infective dermatitis in children. (9554295)
1998
40
Chronic actinic dermatitis occurring in young patients with atopic dermatitis. (9990386)
1998
41
Cytokines and irritant contact dermatitis. (10022266)
1998
42
T-lymphocyte subpopulations (CD4, CD8), IL-4 and IFN-gamma concentration in stimulated cell culture (PBMC) in children with atopic dermatitis. (8775293)
1995
43
Atopic dermatitis: recent trends in pathogenesis and therapy. (8288906)
1994
44
Chronic actinic dermatitis. (8432922)
1993
45
Effectiveness of various barrier preparations in preventing and/or ameliorating experimentally produced Toxicodendron dermatitis. (1430354)
1992
46
Vancomycin-associated exfoliative dermatitis. (2139270)
1990
47
Dermatitis herpetiformis: biochemical properties of the granular deposits of IgA in papillary dermis. Characterization of SDS-soluble IgA-like material and potentially antigen-binding IgA fragments released by pepsin. (3920330)
1985
48
Protein-losing enteropathy in dermatitis herpetiformis. (4743427)
1973
49
Lactate dehydrogenase patterns in blister fluid ad in exfoliative dermatitis. (5676861)
1968
50
101 cases of exfoliative dermatitis. (14010739)
1963

Genetic Variations for Dermatitis

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Expression for genes affiliated with Dermatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dermatitis

Search GEO for disease gene expression data for Dermatitis.

Pathways for genes affiliated with Dermatitis

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Dermatitis

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Dermatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1allergens4411.9HRH1, IL5, CXCR3, IGHE, FLG, CCL27
2retinoic acid44 2412.9IGHE, FLG, CCR4, CCL11, IL5, ADH5
3tarc4411.8CCL11, CCR4, CCL27, IGHE, IL5, CXCR3
4rantes4411.8HRH1, CCR4, CCL11, CCL27, IL5, CXCR3
5dexamethasone44 49 28 1114.7CCL11, IL5, CXCR3, IGHE, CCL27, HRH1
6arginine4411.7IL5, CXCR3, DHX8, IGHE, FLG, ADH5
7histamine44 28 2413.6IL5, HRH1, IGHE, CCL11, CXCR3
8pge24411.5IL5, CCL11, CCL27, CXCR3, HRH1
9sodium cromoglycate4411.5IGHE, CCL11, IL5, HRH1
10cetirizine44 28 11 2414.5IL5, IGHE, CCL11, HRH1
11ketotifen44 1112.5IGHE, HRH1, IL5, CCL11
12ccl344 2812.5CCL11, CCR4, CXCR3, CCL27
13ccl444 2812.5CXCR3, CCL27, CCR4, CCL11
14prednisolone44 28 1113.5IGHE, IL5, CCR4, CCL11
15tacrolimus44 49 1113.4HRH1, IL5, CCL11, CXCR3
16mepyramine maleate5911.4DHX34, HRH1, DHX8
17histamine dihydrochloride5911.4DHX8, DHX34, HRH1
182-pyridylethylamine dihydrochloride5911.3DHX34, DHX8, HRH1
19clemastine fumarate5911.3HRH1, DHX34, DHX8
20unicap4411.3IGHE, IL5, CCL11
21oxatomide4411.3HRH1, IGHE, IL5
22anti-histamine4411.3IGHE, CCL11, HRH1
23astemizole44 59 28 1114.3DHX8, DHX34, HRH1
24nedocromil sodium4411.3IGHE, IL5, HRH1
25azelastine44 1112.3HRH1, IGHE, IL5
26indomethacin44 59 28 1114.3CCL11, IGHE, IL5, HRH1
27montelukast44 49 28 1114.3IL5, IGHE, CCL11
28budesonide44 49 1113.3IGHE, IL5, CCL11
29salbutamol44 49 28 11 2415.3IL5, CCL11, IGHE
30fluticasone propionate44 49 59 1114.3IGHE, CCL11, IL5
31pgd24411.3IGHE, CCL11, IL5
32infliximab44 49 1113.2IGHE, CXCR3, FLG
33methacholine44 1112.2CCL11, IGHE, IL5
34capsaicin44 2812.2IL5, IGHE, HRH1
35levocetirizine4411.1HRH1, CCL11
36omalizumab44 1112.1IL5, IGHE
37levocabastine44 28 1113.1HRH1, IL5
38beclomethasone dipropionate4411.0IGHE, IL5
39ovomucoid4411.0IL5, IGHE
40lte44411.0IL5, CCL11
41toluene diisocyanate4411.0IL5, IGHE
425-oxoete4411.0IL5, CCL11
43desloratadine44 1111.9HRH1, IGHE
44epinastine44 1111.9IL5, HRH1
45roxithromycin44 28 1112.9IL5, CCL11
46olopatadine44 1111.8HRH1, IGHE
47pranlukast44 28 1112.8CCL11, IL5
48loratadine44 11 2412.8HRH1, IGHE
49fexofenadine44 49 11 2413.7IL5, HRH1
50mcp 14410.5CXCR3, IL5

GO Terms for genes affiliated with Dermatitis

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16Gene Ontology
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Biological processes related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.1CCL11, CCR4, CXCR3, IL5, HRH1
2chemotaxisGO:00693511.1CXCR3, CCL27, CCR4, CCL11
3immune responseGO:00695510.9IL5, IGHE, CCL27, CCR4, CCL11
4eosinophil chemotaxisGO:04824510.8HRH1, CCL11

Molecular functions related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.8CXCR3, CCR4

Products for genes affiliated with Dermatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet