MCID: DRM006
MIFTS: 60

Dermatitis malady

Skin category

Summaries for Dermatitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Dermatitis (from Greek: δέρμα derma \"skin\") or eczema (from Greek: ἔκζεμα ekzema... more...

MalaCards: Dermatitis, also known as other chronic dermatitis due to solar radiation, is related to atopic dermatitis and allergic contact dermatitis. An important gene associated with Dermatitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The drugs clobetasol and cod liver oil and the compounds allergens and retinoic acid have been mentioned in the context of this disorder.

Aliases & Classifications for Dermatitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

dermatitis 8 10 45 61
other chronic dermatitis due to solar radiation 8
other dermatitis due to solar radiation 8
skin inflammation nos 8
dermatitis, nos 8
dermatitis nos 8


External Ids:

Disease Ontology8 DOID:2723
NCIt40 C2983
MeSH35 D003872
ICD1025 L30

Related Diseases for Dermatitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 529)
idRelated DiseaseScoreTop Affiliating Genes
1atopic dermatitis32.0KLK7, CCL11, CCR4, CCL27, FLG, IGHE
2allergic contact dermatitis31.7CCL27
3asthma30.8IL5, IGHE
4arthritis30.8CXCR3, FLG
5atopy30.7IL5, CXCR3, IGHE, FLG, CCL11
6eczema herpeticum30.6IGHE
7urticaria30.6HRH1, IGHE
8bullous pemphigoid30.6CCL11, FLG, IGHE, IL5
9allergic asthma30.3CCL11, CCR4, FLG, IGHE, IL5, HRH1
10mycosis fungoides30.3IL5, CXCR3, CCL27, CCR4
11folliculitis30.3CCL11
12allergic rhinitis30.1CCL11, CCR4, FLG, IGHE, CXCR3, IL5
13netherton syndrome30.0IGHE, KLK7
14allergic conjunctivitis29.9CCL11, IGHE, IL5, HRH1
15bronchitis29.9CCL11, IGHE, IL5
16angioedema29.9HRH1, IL5, IGHE
17eosinophilic gastroenteritis29.8CCL11, IGHE, IL5
18onchocerciasis29.8IL5
19pulmonary disease, chronic obstructive29.8CXCR3, CCR4, CCL11
20vernal keratoconjunctivitis29.6IL5, CXCR3, IGHE, CCL11
21ipex syndrome29.6CCL11, CCR4, CCL27, IGHE, CXCR3
22uveitis29.6CCL11, CCR4, CXCR3
23hypereosinophilic syndrome29.6CCL11, IGHE, IL5
24strongyloidiasis29.6IL5, IGHE
25hepatitis b29.6CCL27, NACA
26helminthiasis29.6IGHE, IL5
27allergic bronchopulmonary aspergillosis29.6IL5, IGHE
28churg-strauss syndrome29.6IL5
29pemphigus vulgaris29.6CCL11
30tuberculosis29.6CXCR3, CCR4
31occupational dermatitis11.0
32exfoliative dermatitis10.9
33granulomatous dermatitis10.8
34chronic actinic dermatitis10.8
35cercarial dermatitis10.6
36autoimmune progesterone dermatitis10.6
37contagious pustular dermatitis10.5
38erythema multiforme10.5
39celiac disease10.5
40seborrheic infantile dermatitis10.4
41n syndrome10.4
42dermatitis, atopic 110.4
43photoallergic dermatitis10.4
44ichthyosis vulgaris10.4
45toxicodendron dermatitis10.4
46juvenile dermatitis herpetiformis10.4
47alopecia10.3
48rosacea10.3
49phototoxic dermatitis10.3
50spongiotic dermatitis10.3

Graphical network of the top 20 diseases related to Dermatitis:



Diseases related to dermatitis

Clinical Features for Dermatitis

Drugs & Therapeutics for Dermatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Genetic Tests for Dermatitis

Anatomical Context for Dermatitis

Animal Models for Dermatitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Dermatitis

Sources:
51PubMed
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Articles related to Dermatitis:

(show top 50)    (show all 4448)
idTitleAuthorsYear
1
Japanese patients with psoriasis and atopic dermatitis show distinct personality profiles. (23414205)
2013
2
Many ways lead to Rome: a glance at the multiple immunological pathways underlying atopic dermatitis. (23968381)
2013
3
U.K. standards of care for occupational contact dermatitis and occupational contact urticaria. (23374107)
2013
4
The ABC's of managing patients with severe atopic dermatitis. (23905920)
2013
5
Genetic variants rs2393903 at 10q21.2 and rs6010620 at 20q13.33 are associated with clinical features of atopic dermatitis in the Chinese Han population. (23838578)
2013
6
Patch Testing with Formaldehyde 2.0% in Parallel with 1.0% by the Swedish Contact Dermatitis Research Group. (24337098)
2013
7
Atopic dermatitis induced by systemic immunosupression with tacrolimus--case report. (23862401)
2013
8
Positive patch test reactions in older individuals: retrospective analysis from the North American Contact Dermatitis Group, 1994-2008. (21596455)
2012
9
The effectiveness of jewelweed, Impatiens capensis, the related cultivar I. balsamina and the component, lawsone in preventing post poison ivy exposure contact dermatitis. (22766473)
2012
10
Serum TARC and CTACK concentrations in children with atopic dermatitis, allergic asthma, and urticaria. (22017510)
2012
11
Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect. (22071473)
2012
12
Allergic contact dermatitis caused by dexpanthenol: report of two cases. (22320671)
2012
13
Mixture of Polyphenols and Anthocyanins from Vaccinium uliginosum L. Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice. (23133493)
2012
14
Evaluation of cow's milk allergy in a large group of adolescent and adult patients with atopic dermatitis. (23297520)
2012
15
Bullous systemic lupus erythematosus: differential diagnosis with dermatitis herpetiformis. (22068782)
2011
16
Naturally occurring FCER1A N222K mutation - its ethnicity-dependent distribution and a role in atopic dermatitis. (21216468)
2011
17
Interstitial granulomatous dermatitis with arthritis associated with trastuzumab. (19744176)
2010
18
Dermatitis herpetiformis exacerbated by cornstarch. (20159319)
2010
19
Cell phone allergic contact dermatitis: case report and review. (20579464)
2010
20
Role of T cells in the pathogenesis of atopic dermatitis. (19040465)
2009
21
Exogenous histamine aggravates eczema in a subgroup of patients with atopic dermatitis. (19197542)
2009
22
Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis. (19438598)
2009
23
Three cases of allergic contact dermatitis to 4,4'-diaminodiphenylmethane. (19489974)
2009
24
Lack of detection of circulating skin-specific IgE autoantibodies in dogs with moderate or severe atopic dermatitis. (18068810)
2008
25
Granulomatous dermatitis due to blepharopigmentation. (18211419)
2008
26
In vivo levels of IL-4, IL-10, TGF-beta1 and IFN-gamma mRNA of the peripheral blood mononuclear cells in patients with alopecia areata in comparison to those in patients with atopic dermatitis. (17021766)
2007
27
Irritant contact dermatitis from exposure to povidone-iodine may resemble toxic epidermal necrolysis. (17459298)
2006
28
Anti-IL-5 recombinant humanized monoclonal antibody (mepolizumab) for the treatment of atopic dermatitis. (15813818)
2005
29
Interstitial granulomatous dermatitis with plaques associated with antiphospholipid syndrome. (15840129)
2005
30
Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice. (15086555)
2004
31
Clinical usefulness of oral itraconazole, an antimycotic drug, for refractory atopic dermatitis. (15564204)
2004
32
Dermatitis herpetiformis and gluten-sensitive enteropathy in a patient with nodular prurigo. (11952305)
2002
33
Dermatitis herpetiformis: should direct immunofluorescence be the only diagnostic criterion? (12220281)
2002
34
The effect of suplatast tosilate on immunological parameters for the patients with atopic dermatitis]. (11197882)
2000
35
Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells. (9764843)
1998
36
Nucleotide sequence comparison of the IgE constant region in patients with atopic dermatitis and non-atopic individuals. (9395893)
1997
37
Epidermal expression of 65 and 72 kd heat shock proteins in psoriasis and AIDS-associated psoriasiform dermatitis. (7490370)
1995
38
Risk indicators of reaginic allergy: relations between atopic dermatitis and serum specific IgE of various pneumallergens]. (8734080)
1995
39
Dermatitis herpetiformis and established coeliac disease. (8286252)
1993
40
A simple method for elution of IgA deposits from the skin of patients with dermatitis herpetiformis. (2688562)
1989
41
Acute renal failure, eosinophilia thrombocytopenia and exfoliative dermatitis associated with captopril therapy. (2977230)
1988
42
Occupational dermatitis from Mesonia chinensis. (2966699)
1988
43
Anal squamous cell carcinoma arising on radio-dermatitis cured with chemotherapy alone: case report. (3660479)
1987
44
Hyperlinear palms in atopic dermatitis: a manifestation of ichthyosis vulgaris? (6467975)
1984
45
Occupational dermatitis associated with straw itch mites (Pyemotes ventricosus). (6210784)
1982
46
Photoallergic dermatitis from 8-methoxypsoralen. (148873)
1978
47
Recurrent granulomatous dermatitis with eosinophilia. (5570262)
1971
48
Protein-losing enteropathy in dermatitis herpetiformis. (5429862)
1970
49
A prognostic study of occupational dermatitis cases in a chemical works. (4225727)
1967
50
A Case of General Exfoliative Dermatitis (Pityriasis Rubra) accompanied with Fever and General Prostration. (20748013)
1875

Genetic Variations for Dermatitis

Expression for genes affiliated with Dermatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dermatitis

Search GEO for disease gene expression data for Dermatitis.

Pathways for genes affiliated with Dermatitis

Sources:
52QIAGEN, 30KEGG, 54Reactome, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Dermatitis

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience
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Compounds related to Dermatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1allergens4511.9HRH1, CCL11, CCL27, FLG, IGHE, CXCR3
2retinoic acid45 2412.9KLK7, CCL11, CCR4, FLG, IGHE, IL5
3tarc4511.8CCL11, CCR4, CCL27, IGHE, CXCR3, IL5
4rantes4511.8CCL11, CCR4, CCL27, CXCR3, IL5, HRH1
5dexamethasone45 50 29 1114.7CCL11, CCL27, IGHE, CXCR3, IL5, HRH1
6arginine4511.7FLG, IGHE, DHX8, CXCR3, IL5, ADH5
7histamine45 29 2413.6CCL11, IGHE, CXCR3, IL5, HRH1
8pge24511.5CCL11, CCL27, CXCR3, IL5, HRH1
9sodium cromoglycate4511.5HRH1, IL5, IGHE, CCL11
10cetirizine45 29 11 2414.5CCL11, IGHE, IL5, HRH1
11ketotifen45 1112.5HRH1, IL5, IGHE, CCL11
12ccl345 2912.5CXCR3, CCL27, CCR4, CCL11
13ccl445 2912.5CCL11, CCR4, CCL27, CXCR3
14prednisolone45 29 1113.5CCL11, CCR4, IGHE, IL5
15tacrolimus45 50 1113.4HRH1, IL5, CXCR3, CCL11
16histamine dihydrochloride6011.4DHX34, DHX8, HRH1
17mepyramine maleate6011.4HRH1, DHX34, DHX8
18clemastine fumarate6011.3DHX8, DHX34, HRH1
192-pyridylethylamine dihydrochloride6011.3DHX8, DHX34, HRH1
20unicap4511.3IL5, IGHE, CCL11
21oxatomide4511.3IGHE, IL5, HRH1
22anti-histamine4511.3HRH1, IGHE, CCL11
23astemizole45 60 29 1114.3DHX8, DHX34, HRH1
24nedocromil sodium4511.3IGHE, IL5, HRH1
25azelastine45 1112.3HRH1, IL5, IGHE
26indomethacin45 60 29 1114.3HRH1, IL5, IGHE, CCL11
27montelukast45 50 29 1114.3CCL11, IGHE, IL5
28budesonide45 50 1113.3CCL11, IGHE, IL5
29salbutamol45 50 29 11 2415.3IL5, IGHE, CCL11
30fluticasone propionate45 50 60 1114.3CCL11, IGHE, IL5
31pgd24511.3IL5, IGHE, CCL11
32infliximab45 50 1113.2FLG, IGHE, CXCR3
33methacholine45 1112.2CCL11, IGHE, IL5
34capsaicin45 2912.2HRH1, IL5, IGHE
35levocetirizine4511.1HRH1, CCL11
36omalizumab45 1112.1IL5, IGHE
37levocabastine45 29 1113.1IL5, HRH1
38beclomethasone dipropionate4511.0IGHE, IL5
39ovomucoid4511.0IL5, IGHE
40toluene diisocyanate4511.0IGHE, IL5
41lte44511.0CCL11, IL5
42desloratadine45 1112.0IGHE, HRH1
43epinastine45 1111.9IL5, HRH1
445-oxoete4510.9CCL11, IL5
45olopatadine45 1111.9IGHE, HRH1
46roxithromycin45 29 1112.8CCL11, IL5
47fexofenadine45 50 11 2413.8IL5, HRH1
48pranlukast45 29 1112.8IL5, CCL11
49loratadine45 11 2412.7IGHE, HRH1
50mcp 14510.5IL5, CXCR3

GO Terms for genes affiliated with Dermatitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.1CCL11, CCR4, CXCR3, IL5, HRH1
2chemotaxisGO:00693511.1CXCR3, CCL27, CCR4, CCL11
3immune responseGO:00695510.9IL5, IGHE, CCL27, CCR4, CCL11
4eosinophil chemotaxisGO:04824510.8HRH1, CCL11

Molecular functions related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.8CXCR3, CCR4

Products for genes affiliated with Dermatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dermatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet