Dermatitis disease: drugs, articles, genes, clinical trials

Summaries for Dermatitis

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⁴⁴Wikipedia, ²²MalaCards
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Wikipedia: Dermatitis is inflammation of the skin (i.e. rash).⁴⁴ more...

MalaCards: Dermatitis, also known as other chronic dermatitis due to solar radiation, is related to atopic dermatitis and carcinoma. An important gene associated with Dermatitis is FAF2 (Fas associated factor family member 2), and among its related pathways are p38 Signaling and Tec Kinases Signaling. The drugs alclometasone dipropionate and alclometasone and the compounds lipid and superoxide have been mentioned in the context of this disorder. Affiliated tissues include whole blood, thymus and brain, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Descriptions for Dermatitis

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Sources:
⁶Disease Ontology, ⁷diseasecard, ⁸DISEASES, ³²Novoseek , ⁴³UMLS, ²⁴MeSH, ⁴⁰SNOMED-CT, ²⁷NCIt
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Aliases & Descriptions:

dermatitis ⁶ ⁷ ⁸ ³² ⁴³

other chronic dermatitis due to solar radiation ⁶

other dermatitis due to solar radiation ⁶

skin inflammation nos (disorder) ⁶

dermatitis nos (disorder) ⁶

skin inflammation nos ⁶

dermatitis (disorder) ⁶

chronic dermatitis ⁴³

dermatitis, nos ⁶

dermatitis nos ⁶

External Ids:

MeSH²⁴ D003872

SNOMED-CT⁴⁰ 156388001, 156358005, 4979002 182782007, 200884006, 238538009, 267847004, 267856007, 43116000, more

NCIt²⁷ C2983

UMLS⁴³ C0011603

Related Diseases for Dermatitis

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Sources:
¹³GeneCards, ¹⁴GeneDecks
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Diseases related to dermatitis by text searches and GeneDecks gene sharing:

(show top 50) (show all 1005)

id	Related Disease	Score	Top Affiliating Genes
1	atopic dermatitis	66.3	PDE4A, REL, KITLG, SELE, SELL, SELP
2	carcinoma	64.2	PIK3C2A, PI3, NCR3, PDE3B, PDE4A, REL
3	psoriasis	59.3	ZNF750, PI3, PDE4A, CNR1, KIR3DL2, KITLG
4	leukemia	58.5	PIK3C2A, NCR1, NCR2, NCR3, PDE3B, PDE4A
5	rhinitis	50.4	PDE4A, RELA, KITLG, SFTPD, BTK, SELE
6	atopy	49.5	RELA, KITLG, SELP, NAT1, NAT2, VEGFA
7	neuronitis	48.4	PIK3C2A, KLHL2, PDE3B, PDE4A, REL, RELA
8	eczema	47.0	BTK, SELE, VIP, CMA1, LGALS3, LCE3B
9	fibrosis	46.3	PI3, PDE4A, RELA, CNR1, KITLG, SFTPD
10	skin disease	44.9	PI3, PDE4A, SFTPD, SELE, SELL, VIP
11	bronchial asthma	44.0	PDE3B, KITLG, SFTPD, SELE, SELL, SELP
12	allergic asthma	42.7	PDE3B, PDE4A, SFTPD, SELE, SELL, NAT2
13	pulmonary disease	41.2	PI3, PDE4A, SFTPD, SELE, SELL, SELP
14	diabetes mellitus	41.1	PIK3C2A, PI3, PDE3B, PDE4A, CNR1, BTD
15	dermatitis herpetiformis	40.8	SELE, MYO9B, CD79A, CD40LG, ITGAM, MMP12
16	eosinophilia	40.7	PIK3C2A, PDE3B, PDE4A, KIAA0101, SFTPD, SELL
17	blindness	40.0	PIK3C2A, PDE4A, CNR1, SELE, SELP, VIP
18	osteoarthritis	39.3	PDE4A, RELA, CNR1, VIM, VIP, VEGFA
19	immunodeficiency	38.8	BTK, SELL, VIP, CIITA, CFLAR, CD79A
20	contact dermatitis	38.6	FLG, IL1A, IL5, CCR4, IGHE, CYP1B1
21	urticaria	38.4	KITLG, SELE, SELP, SERPING1, VEGFA, VCAM1
22	herpes simplex	37.4	NCR1, NCR2, VIM, VEGFA, CLDN1, BGLAP
23	sinusitis	37.2	PI3, RELA, SFTPD, BTK, SELL, SELP
24	tonsillitis	36.9	VIM, VEGFA, CMA1, BDNF, BCL2, MUC1
25	mycosis fungoides	36.1	CNFN, SELE, SELP, VCAM1, BCL2, S100A8
26	duodenitis	36.0	KITLG, VIP, CMA1, BCL2, LGALS3, LEP
27	retinitis	35.9	PIK3C2A, PDE3B, PDE4A, CNR1, KITLG, SELE
28	asthma	35.4	IL13, IL4, IL5, IGES, IGHE, RNASE3
29	alopecia	35.4	KITLG, BTD, CLDN1, CIITA, MX1, MUC1
30	chronic obstructive pulmonary disease	35.1	PI3, PDE4A, SFTPD, NAT2, ATP2A2, MPO
31	ichthyosis	34.9	RELA, CLDN1, LBR, KAL1, IVL, ITGB7
32	alopecia areata	34.9	CIITA, MX1, CD79A, CD40, GZMB, FLG
33	thrombosis	34.7	PIK3C2A, SELE, SELL, SELP, VEGFA, VCAM1
34	lichen planus	34.6	RELA, VEGFA, VCAM1, BCL2, MX1, JUN
35	gonococcal synovitis	34.6	PI3, PDE3B, PDE4A, REL, RELA, RELB
36	measles	34.5	RELA, SFTPD, SELE, VCAM1, CIITA, MX1
37	eczema herpeticum	34.2	CDSN, FLG2, FLG, IL7R, IGHE, CAMP
38	allergic contact dermatitis of eyelid	34.2	SELE, NAT2, FLG, IL17A, IL4R, IL5
39	vaccinia	34.2	KLHL2, NCR1, NCR2, RELA, KITLG, CIITA
40	diaper rash	33.1	VNN3, LCE2B, LCE3A, LCE5A, FLG2, IL1A
41	arthritis	33.0	SELL, VIP, MMP3, IL17A, IL1A, IL1B
42	ichthyosis vulgaris	32.9	CDSN, IVL, FLG2, FLG, LOR, SPRR1B
43	hyper-ige syndrome	32.9	SELL, MMP3, MMP9, IL10, IL13, IL17A
44	pemphigus	32.4	CIITA, JUN, CD79A, CD40LG, CD40, CDH1
45	rheumatoid arthritis	32.3	CIITA, CD40, MIF, IL10, IL1B, IL1RN
46	twinning	32.0	BTD, BTK, VEGFA, LIF, BGLAP, BDNF
47	acquired immunodeficiency syndrome	31.8	SFTPD, SELE, VEGFA, VCAM1, BCL2, CIITA
48	cutaneous t cell lymphoma	31.6	SELE, SELL, GZMB, IL15, IL2, IL2RA
49	toxic shock syndrome	31.5	PIK3C2A, SETBP1, CIITA, LBR, CD69, CD4
50	bullous pemphigoid	31.3	CIITA, CD79A, IVL, ITGA6, FLG, FCER2

Graphical network of the top 20 diseases related to dermatitis:

Graphical network of diseases related to dermatitis

Clinical Features for Dermatitis

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Drugs & Therapeutics for Dermatitis

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Sources:
⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials, ⁴³UMLS, ²⁸NDF-RT
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Approved drugs:

Search CenterWatch for dermatitis

Drug clinical trials:

Search ClinicalTrials for dermatitis

Search NIH Clinical Center for dermatitis

Search CenterWatch for dermatitis

Inferred drug relations via UMLS/NDF-RT:

⁴³ ²⁸ alclometasone, alclometasone dipropionate, amcinonide, clobetasol, clobetasol propionate, cod liver oil [va product], racemethionine, vitamin a, vitamin a (as acetate & beta carotene), vitamin a (as acetate), vitamin a (as palmitate & beta carotene), vitamin a (natural), vitamin a acetate, vitamin a palmitate, vitamin a palmitate (solubilized)

Genetic Tests for Dermatitis

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Anatomical Context for Dermatitis

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²²MalaCards
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MalaCards organs/tissues related to dermatitis:

²²

Whole blood, Thymus, Brain, Spinal cord, Heart, Colon, Liver, Lung, Breast, Skin, Tonsil, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Bronchial epithelium

Phenotypes for genes affiliated with Dermatitis

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²⁵MGI
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MGI Mouse Phenotypes related to dermatitis:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	19.0	NCR1, SGPL1, KIAA0101, BTK, MYO9B, UROS
2	immune system phenotype	MP:0005387	18.4	PDE4A, REL, RELB, SGPL1, KIAA0101, BTK
3	behavior/neurological phenotype	MP:0005386	17.1	RELB, CNR1, BTD, SELE, SELP, SEMA3A
4	integument phenotype	MP:0010771	16.4	PDE3B, REL, RELA, RELB, CNR1, KITLG
5	normal phenotype	MP:0002873	15.2	NCR1, RELA, SELE, SERPING1, VIP, NAT1
6	digestive/alimentary phenotype	MP:0005381	14.2	REL, RELB, SGPL1, KITLG, BTK, VEGFA
7	respiratory system phenotype	MP:0005388	13.7	REL, RELB, SGPL1, SFTPD, SELL, SELP
8	tumorigenesis	MP:0002006	12.6	KITLG, BTK, SELL, BCL11B, BCL2, LEP
9	skeleton phenotype	MP:0005390	12.3	REL, RELA, SGPL1, CNR1, KITLG, SEMA3A
10	liver/biliary system phenotype	MP:0005370	12.1	REL, RELB, VEGFA, LIF, UROD, UROS
11	adipose tissue phenotype	MP:0005375	12.0	PIK3C2A, PDE3B, CNR1, LIF, BCL2, LEP
12	vision/eye phenotype	MP:0005391	11.8	RELA, KITLG, BTD, SELE, SELP, VIM
13	renal/urinary system phenotype	MP:0005367	11.0	SGPL1, BTD, SELP, UROS, BCL2, LGMN
14	pigmentation phenotype	MP:0001186	11.0	PDE3B, KITLG, BTD, BCL2, LEP, ITCH
15	muscle phenotype	MP:0005369	10.7	RELA, RELB, SGPL1, BTD, VIM, NACA
16	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, PDE3B, REL, RELA, RELB, SGPL1
17	growth/size phenotype	MP:0005378	INF	PIK3C2A, PDE3B, REL, RELA, RELB, SGPL1
18	cardiovascular system phenotype	MP:0005385	INF	PDE4A, REL, RELA, RELB, SGPL1, KITLG
19	nervous system phenotype	MP:0003631	INF	PDE4A, REL, RELA, CNR1, KITLG, SELP
20	cellular phenotype	MP:0005384	INF	REL, RELA, RELB, SGPL1, CNR1, KIAA0101
21	endocrine/exocrine gland phenotype	MP:0005379	INF	RELB, SGPL1, SELL, , LALBA, CDSN
22	mortality/aging	MP:0010768	INF	PIK3C2A, NCR1, REL, RELA, RELB, SGPL1
23	no phenotypic analysis	MP:0003012	INF	CNR1, SEMA3A, VEGFA, VCAM1, BDNF, BCL11B
24	reproductive system phenotype	MP:0005389	INF	SGPL1, VIP, NAT1, VEGFA, LIF, CLIC4

Publications for genes affiliated with Dermatitis

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³⁵PubMed
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Articles related to dermatitis:

(show top 50) (show all 1132)

id	Title	Authors	Year	Affiliating Genes
1	Kinetics and differential expression of the skin-rela ted chemokines CCL27 and CCL17 in psoriasis, atopic dermatitis and allergic con tact dermatitis. (21707761)	Riis J.L.... Iversen L.	2011	CCL17, CCL27
2	Dermatitis herpetiformis sera or goat anti-transgluta minase-3 transferred to human skin-grafted mice mimics dermatitis herpetiformis immunopathology. (21335491)	Zone J.J.... Meyer L.J.	2011	TGM3
3	Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. (20466416)	Gao P.S.... Barnes K.C.	2010	IL7R, TSLP, CRLF2
4	Molecular diagnostics of psoriasis, atopic dermatitis , allergic contact dermatitis and irritant contact dermatitis. (19818069)	Kamsteeg M.... Schalkwijk J.	2010	CXCL10, NELL2, PI3
5	Quantitative analysis of nerve growth factor (NGF) in the atopic dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic dermatitis. (18922683)	Yamaguchi J.... Ikezawa Z.	2009	NGF
6	Expression of COUP-TF-interacting protein 2 (CTIP2) i n human atopic dermatitis and allergic contact dermatitis skin. (19366371)	Ganguli-Indra G.... Indra A.K.	2009	BCL11B
7	IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis. (19220774)	Zitnik S.E.... Nickel R.	2009	IL13, IGHE
8	Serum measurement of thymus and activation-regulated chemokine/CCL17 in children with atopic dermatitis: elevated normal levels in i nfancy and age-specific analysis in atopic dermatitis. (19236603)	Fujisawa T.... Tamaki K.	2009	CCL17
9	The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis. (18234309)	Mrabet-Dahbi S.... Renz H.	2008	IL8, TLR2
10	Investigation of the eotaxin gene -426C-->T, -384A-->G and 67G-->a single-nucleotide polymorphisms and atopic dermatitis in Italian children using family-based association methods. (18312459)	Rigoli L.... Pajno G.B.	2008	CCL11
11	Lack of detection of circulating skin-specific IgE autoantibodies in dogs with moderate or severe atopic dermatitis. (18068810)	Olivry T.... Hammerberg B.	2008	IGHE
12	Association factors for atopic dermatitis in nursery school children in Ishigaki islands - Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). (18693163)	Fukiwake N.... Furue M.	2008	IGHE
13	The effect of wet-wrap dressing on epidermal barrier in patients with atopic dermatitis. (17958842)	Lee J.H.... Bang D.	2007	FLG, LOR
14	Attenuation of allergic contact dermatitis through the endocannabinoid system. (17556587)	Karsak M.... Zimmer A.	2007	CNR1
15	Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis. (18056398)	Gainers M.E.... Dimitroff C.J.	2007	SELP, SELE
16	Intracellular production of IL-2, IL-4, IFN-gamma, and TNF-alpha by peripheral blood CD3+ and CD4+ T cells in children with atopic dermatitis. (17120040)	Machura E.... Karczewska K.	2007	TNF, IL2, IL4
17	Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). (17673383)	Furusyo N.... Hayashi J.	2007	CCL17
18	Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. (16550169)	Palmer C.N.A.... McLean W.H.I.	2006	FLG
19	CT genotype of promotor polymorphism C159T in the CD14 gene is associated with lower prevalence of atopic dermatitis and lower IL-13 production. (16101942)	Lange J.... Kopp M.	2005	CD14, IL13
20	The objective severity assessment of atopic dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis. (16181458)	Angelova-Fischer I.... Fluhr J.W.	2005	IL16
21	Etiopathogenesis of atopic dermatitis--an overview. (15788148)	Pastar Z.... LjubojeviA8 S.	2005	IFNG
22	Allergic contact dermatitis from natural rubber latex in atopic dermatitis and the risk of later Type I allergy. (15982232)	Guillet G.... Dagregorio G.	2005	IGHE
23	WBN/Kob-Ht rats spontaneously develop dermatitis under conventional conditions: another possible model for atopic dermatitis. (16365525)	Asakawa M.... Horikawa T.	2005	IL4, IGHE
24	Impaired interferon-gamma production in a subset population of severe atopic dermatitis. (15178894)	Katsunuma T.... Saito H.	2004	IFNG
25	IL-13 gene expression in patients with atopic dermatitis: relation to IgE level and to disease severity. (16734130)	Metwally S.S.... El-Chennawi F.A.	2004	IL13, IGHE
26	Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life. (15305939)	Hagendorens M.M.... Stevens W.J.	2004	IL2, IL4, IFNG
27	Impaired responses of peripheral blood mononuclear cells to nickel in patients with nickel-allergic contact dermatitis and concomitant atopic dermatitis. (15030331)	Buchvald D.... Lundeberg L.	2004	LBR, IL5
28	Characterization of chemokine receptor expression and cytokine production in circulating CD4+ T cells from patients with atopic dermatitis: up-regulation of C-C chemokine receptor 4 in atopic dermatitis. (12190665)	Okazaki H.... Minota S.	2002	CCR3, CXCR3, CCR4
29	Dichotomic nature of atopic dermatitis reflected by combined analysis of monocyte immunophenotyping and single nucleotide polymorphisms of the interleukin-4/interleukin-13 receptor gene: the dichotomy of extrinsic and intrinsic atopic dermatitis. (12406333)	Novak N.... Bieber T.	2002	IL13, IGHE
30	Eotaxin gene single nucleotide polymorphisms in the promoter and exon regions are not associated with susceptibility to atopic dermatitis, but two of them in the promoter region are associated with serum IgE levels in patients with atopic dermatitis. (12234713)	Tsunemi Y.... Tamaki K.	2002	CCL11
31	Serum IgE reactivity to Malassezia furfur extract and recombinant M. furfur allergens in patients with atopic dermatitis. (11859945)	Zargari A.... Scheynius A.	2001	IGHE
32	A comparative study of the expression of cytotoxic proteins in allergic contact dermatitis and psoriasis: spongiotic skin lesions in allergic contact dermatitis are highly infiltrated by T cells expressing perforin and granzyme B. (11238028)	Yawalkar N.... Braathen L.R.	2001	GZMB
33	Induction of atopic dermatitis-like skin lesion in NC/Nga mice--the influence of the skin barrier destroying solution to the induction of dermatitis (11830999)	Unno T.... Ra C.	2001	IGHE
34	Topical tacrolimus (FK506) leads to profound phenotypic and functional alterations of epidermal antigen-presenting dendritic cells in atopic dermatitis. (11240954)	Wollenberg A.... Bieber T.	2001	IGHE
35	Interleukin-18 is elevated in the sera from patients with atopic dermatitis and from atopic dermatitis model mice, NC/Nga. (11490156)	Tanaka T.... Suemura M.	2001	IL18
36	The mechanism of a defective IFN-gamma response to bacterial toxins in an atopic dermatitis model, NC/Nga mice, and the therapeutic effect of IFN-gamma, IL-12, or IL-18 on dermatitis. (11313381)	Habu Y.... Hiraide H.	2001	IL18, IL4, IFNG
37	Expression of 27 KD, 65 KD and 72/73 KD heat shock protein in atopic dermatitis: comparison with those in normal skin and contact dermatitis. (10920582)	Ghoreishi M.... Nishioka K.	2000	HSPB2
38	Comparison of severity scoring of atopic dermatitis values and serum levels of eosinophil cationic protein and mast cell tryptase for routine evaluation of atopic dermatitis. (11028863)	Amon U.... Amon S.	2000	RNASE3
39	Long-term therapy with recombinant interferon-gamma (rIFN-gamma) for atopic dermatitis. (9532976)	Schneider L.C.... Zurakowski D.	1998	IFNG
40	Modulation of cutaneous SP receptors in atopic dermatitis after UVA irradiation. (9534883)	Staniek V.... Misery L.	1998	TACR1
41	Interferon-gamma promotes exaggerated cytokine production in keratinocytes cultured from patients with atopic dermatitis. (9564808)	Pastore S.... Girolomoni G.	1998	IFNG, IL1RN, IL1RAPL2
42	Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells. (9764843)	Cavani A.... Girolomoni G.	1998	IL10
43	Immunohistochemical characterization of HSP, alpha-MSH, Merkel cells and neuronal markers in acute UV dermatitis and acute contact dermatitis in vivo. (9372313)	Bayerl C.... Jung E.G.	1997	ENO2, POMC, NGFR
44	Serum levels of eosinophil cationic protein reflect the state of in vitro degranulation of blood hypodense eosinophils in atopic dermatitis. (8708149)	Miyasato M.... Sasai Y.	1996	RNASE3
45	A screening of skin changes, with special emphasis on neurochemical marker antibody evaluation, in patients claiming to suffer from 'screen dermatitis' as compared to normal healthy controls. (8981027)	Johansson O.... Han S.W.	1996	ENO2, PNMT
46	Presence of IgE antibodies to staphylococcal exotoxin s on the skin of patients with atopic dermatitis. Evidence for a new group of a llergens. (7690780)	Leung D.Y.... Sampson H.A.	1993	IGHE
47	In vitro interleukin 4 and interferon-gamma productio n by mononuclear cells from atopic dermatitis patients. (18475556)	Well S.... Diel F.	1993	IL4, IFNG
48	Fc epsilon receptor II/CD23+ lymphocytes in atopic dermatitis. III. Aberrant control in the in vitro expression of Fc epsilon RII/CD23 on peripheral blood T cells in atopic dermatitis. (1531123)	Sakamoto T.... Takigawa M.	1992	IL4, IFNG, FCER2
49	Lesional elastase activity in psoriasis, contact dermatitis, and atopic dermatitis. (1512467)	Wiedow O.... Christophers E.	1992	ELANE
50	Modulation of leucocyte adhesion molecules, a T-cell chemotaxin (IL-8) and a regulatory cytokine (TNF-alpha) in allergic contact dermatitis (rhus dermatitis). (1712219)	Griffiths C.E.... Nickoloff B.J.	1991	ICAM1, IL8, SELE

Genes related to Dermatitis

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¹³GeneCards
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Genes related to dermatitis according to GeneCards:

(show top 50) (show all 560)

id	Symbol	Description	Score	GeneCards Section Context
1	FAF2	Fas associated factor family member 2	11.1	Publications, Aliases & Descriptions, UniProt Related, Summaries
2	CCL11	chemokine (C-C motif) ligand 11	11.1	Publications, Summaries
3	ZNF750	zinc finger protein 750	11.0	Publications, Summaries
4	KLK7	kallikrein-related peptidase 7	11.0	Publications, Summaries
5	HRH1	histamine receptor H1	11.0	Summaries
6	ATOD	Dermatitis, atopic	11.0	Publications, Aliases & Descriptions
7	ATOD3	Dermatitis, atopic, 3	11.0	Publications, Aliases & Descriptions
8	ATOD5	Dermatitis, atopic, 5	11.0	Publications, Aliases & Descriptions
9	ATOD6	Dermatitis, atopic, 6	11.0	Publications, Aliases & Descriptions
10	NACA	nascent polypeptide-associated complex alpha subunit	11.0	Publications, Summaries
11	ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	11.0	Summaries
12	COL6A5	collagen, type VI, alpha 5	11.0	Publications, Summaries
13	DHX34	DEAH (Asp-Glu-Ala-His) box polypeptide 34	11.0	Summaries
14	ATOD7	Dermatitis, atopic, susceptibility to, 7	11.0	Aliases & Descriptions
15	FLG	filaggrin	11.0	Publications
16	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
17	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
18	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
19	CCL27	chemokine (C-C motif) ligand 27	11.0	Publications
20	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
21	IL13	interleukin 13	11.0	Publications
22	SELE	selectin E	11.0	Publications
23	ICAM1	intercellular adhesion molecule 1	11.0	Publications
24	IFNG	interferon, gamma	11.0	Publications
25	IL17A	interleukin 17A	11.0	Publications
26	IL1A	interleukin 1, alpha	11.0	Publications
27	TNF	tumor necrosis factor	11.0	Publications
28	IL31	interleukin 31	11.0	Functions, Publications
29	CCL22	chemokine (C-C motif) ligand 22	11.0	Expressions, Publications
30	IL4	interleukin 4	11.0	Publications
31	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
32	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
33	IL16	interleukin 16	11.0	Publications
34	IL4R	interleukin 4 receptor	11.0	Publications
35	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
36	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
37	TACR1	tachykinin receptor 1	11.0	Publications
38	IL8	interleukin 8	11.0	Publications
39	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
40	VNN3	vanin 3	11.0	Publications
41	CCR10	chemokine (C-C motif) receptor 10	11.0	Publications
42	LOR	loricrin	11.0	Publications
43	IL17D	interleukin 17D	11.0	Publications
44	KRT16	keratin 16	11.0	Publications
45	TGM3	transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
46	DEFB4A	defensin, beta 4A	11.0	Publications
47	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
48	LBR	lamin B receptor	11.0	Publications
49	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
50	IL2RB	interleukin 2 receptor, beta	11.0	Publications

Expression for genes affiliated with Dermatitis

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Dermatitis

Pathways for genes affiliated with Dermatitis

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Sources:
³⁶QIAGEN, ²⁰KEGG, ³⁸Reactome, ⁴¹Thomson Reuters, ¹⁰EMD Millipore, ³⁷R&D Systems
See all sources

Pathways related to dermatitis according to GeneDecks:

(show top 50) (show all 159)

id	Pathway	Score	Top Affiliating Genes
1	p38 Signaling³⁶	17.7	KITLG, BTK, SEMA3A, LIF, LIFR, BDNF
2	Tec Kinases Signaling³⁶	17.6	KITLG, BTK, SEMA3A, LIFR, BDNF, BCL2
3	Cytokine-cytokine receptor interaction²⁰	17.5	KITLG, VEGFA, LIF, LIFR, LEP, CD70
4	Antioxidant Action of Vitamin-C³⁶	17.4	KITLG, BTK, SEMA3A, MYO9B, LIF, LIFR
5	Akt Signaling³⁶	17.1	PDE3B, BTK, SEMA3A, LIF, LIFR, CD2
6	PAK Pathway³⁶	16.8	KITLG, BTK, SEMA3A, MYO9B, LIF, BDNF
7	Molecular Mechanisms of Cancer³⁶	16.0	KITLG, BTK, SEMA3A, LIF, BDNF, BCL2
8	all-trans-Retinoic Acid Signaling in Brain³⁶	15.8	BTK, LIF, BCL2, CD2, CD80, IL10
9	MAPK Family Pathway³⁶	15.7	KITLG, BTK, SEMA3A, BDNF, BCL2, JUN
10	JAK-STAT Pathway³⁶	15.4	KITLG, BTK, SEMA3A, LIFR, BDNF, BCL2
11	MIF Regulation of Innate Immune Cells³⁶	15.4	BTK, LIF, BCL2, JUN, CD2, CD14
12	MIF Mediated Glucocorticoid Regulation³⁶	15.4	BTK, LIF, BCL2, CD2, CD14, CD80
13	Glucocorticoid Receptor Signaling³⁶	15.2	BTK, BCL2, JUN, CD2, CD4, CD80
14	Transendothelial Migration of Leukocytes³⁶	15.0	BTK, VCAM1, MYO9B, CLDN1, ITGA6, ITGAM
15	TGF-Beta Pathway³⁶	15.0	KITLG, BTK, SEMA3A, BDNF, BCL2, JUN
16	ERK Signaling³⁶	14.5	KITLG, BTK, SEMA3A, LIFR, CD2, CD3D
17	NFAT Signaling and Lymphocyte Interactions³⁶	14.5	BTK, BCL2, CD2, CD3D, CD3G, CD4
18	Class A/1 (Rhodopsin-like receptors)³⁸	14.3	CNR1, MC3R, MC5R, CCL4, CCL7, CCL27
19	Immune System³⁸	14.1	NCR2, REL, KIR3DL2, VCAM1, BLMH, LGALS3
20	IL-6 Pathway³⁶	14.0	BTK, CD2, CD80, IL10, IL12A, IL12B
21	Endothelin-1 Signaling Pathway³⁶	13.8	BTK, LIFR, CD2, CD80, IL10, IL12A
22	Chemokine Signaling³⁶	13.8	JUN, IL8, MAPK1, CCL4, CCL7, CCL26
23	Chemokine signaling pathway²⁰	13.6	RELA, IL8, MAPK1, CCL4, CCL7, CCL26
24	Rheumatoid arthritis²⁰	13.5	VEGFA, JUN, CD86, CD80, ITGB2, MMP1
25	Jak-STAT signaling pathway²⁰	13.4	LIFR, LEP, IL10, IL10RA, IL12A, IL12B
26	Intestinal immune network for IgA production²⁰	13.2	CD86, CD40LG, CD80, CD40, ITGB7, IL10
27	Hematopoietic cell lineage²⁰	13.2	KITLG, CD2, CD36, CD3D, CD8A, CD14
28	Toll-like receptor signaling pathway²⁰	13.1	RELA, JUN, CD86, CD14, CD80, CD40
29	Asthma²⁰	12.8	MS4A2, CD40LG, CD40, FCER1A, IL10, IL13
30	Cytokine Network³⁶	12.8	IL10, IL12A, IL12B, IL13, IL15, IL16
31	Immune response_TLR signaling pathways⁴¹	12.7	REL, RELA, RELB, JUN, CD14, IRAK3
32	Cell adhesion molecules (CAMs)²⁰	12.6	SELL, SELP, CLDN1, CD2, CD86, CD8A
33	NF-KappaB Family Pathway³⁶	12.5	REL, RELA, RELB, KITLG, SEMA3A, BDNF
34	THC Differentiation Pathway³⁶	12.4	CD86, IL10, IL10RA, IL12A, IL12B, IL12RB1
35	Allograft rejection²⁰	12.3	CD86, CD40LG, CD80, CD40, GZMB, IL10
36	Autoimmune thyroid disease²⁰	12.3	CD86, CD40LG, CD80, CD40, GZMB, IL10
37	Chagas disease (American trypanosomiasis)²⁰	12.2	RELA, CFLAR, JUN, CD3D, CD3G, IL10
38	NF-KappaB (p50-p65) Pathway³⁶	12.2	RELA, KITLG, SEMA3A, BDNF, IRAK3, IL1A
39	Type I diabetes mellitus²⁰	12.2	CD86, CD80, GZMB, IL12A, IL12B, IL1A
40	Leishmaniasis²⁰	12.1	RELA, JUN, ITGAM, ITGB2, FCGR1A, FCGR3A
41	NFAT in Immune Response³⁶	11.8	KITLG, BTK, SEMA3A, LIFR, BDNF, JUN
42	Immune response IL-22 signaling pathway¹⁰	11.6	BCL2, JUN, CD86, CD4, IL12A, IL12B
43	Immune response_IL-22 signaling pathway⁴¹	11.6	BCL2, JUN, CD86, CD4, IL12A, IL12B
44	Cytokine production by Th17 cells in CF (Mouse model)⁴¹	11.5	REL, RELA, RELB, CD14, FOXP3, IL12B
45	Cytokine production by Th17 cells in CF⁴¹	11.5	REL, RELA, RELB, CD14, IL12B, IL12RB1
46	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types³⁷	11.4	GZMB, IL12B, IL17A, IL17F, IL1B, IL22
47	Bacterial infections in CF airways⁴¹	11.4	REL, RELA, RELB, SFTPD, MUC1, CTSS
48	Graft-versus-host disease²⁰	11.3	KIR3DL2, CD86, CD80, IL1A, IL2, FASLG
49	Immune response MIF-mediated glucocorticoid regulation¹⁰	10.9	REL, RELA, RELB, VCAM1, JUN, MMP1
50	Immune response_MIF-mediated glucocorticoid regulation⁴¹	10.9	REL, RELA, RELB, VCAM1, JUN, MMP1

Compounds for genes affiliated with Dermatitis

about this section

Sources:
³²Novoseek , ¹⁸HMDB, ⁹DrugBank, ⁴²Tocris Bioscience, ³⁴PharmGKB
See all sources

Compounds related to dermatitis according to GeneDecks:

(show top 50) (show all 470)

id	Compound	Score	Top Affiliating Genes
1	lipid³²	21.2	PIK3C2A, PI3, PDE3B, PDE4A, CNR1, KITLG
2	superoxide³² ¹⁸	16.9	PIK3C2A, PI3, PDE3B, PDE4A, KITLG, SELL
3	fmlp³²	15.2	PDE4A, SELL, SELP, VIM, VCAM1, LIF
4	il 10³²	14.6	LIF, CD8A, CD40, IL10, IL10RA, IL12B
5	paraffin³²	14.6	RELA, KITLG, SELL, VIM, VEGFA, VCAM1
6	estrogen³²	14.5	VIP, NAT1, NAT2, LIFR, BGLAP, BDNF
7	genistein³² ⁹ ¹⁸ ⁹	17.1	KITLG, BTK, SELE, SELL, SELP, VIM
8	mannose³²	13.9	SFTPD, LGALS3, CIITA, CD79A, CD69, CD86
9	dopamine³² ⁹ ¹⁸ ⁹	16.8	PDE3B, PDE4A, SELE, VIP, LIF, BDNF
10	peptidoglycan³²	13.6	CIITA, CD14, IL10, IL12B, IL15, IL1B
11	theophylline³² ⁹ ¹⁸ ⁹	16.2	PDE3B, PDE4A, SELL, SELP, CD79A, CD40LG
12	formaldehyde³² ¹⁸	14.2	SELE, SELL, SELP, VIM, LGALS3, MUC1
13	wortmannin³² ⁴²	14.2	PIK3C2A, PI3, PDE3B, PDE4A, KITLG, BTK
14	fluticasone propionate³² ⁴² ⁹ ⁹	16.1	SELE, VCAM1, BGLAP, MPO, MMP9, IL13
15	phospholipid³²	13.1	PDE4A, SFTPD, MUC1, LALBA, S100A1, S100A10
16	methotrexate³² ³⁴ ⁴² ⁹ ⁹	17.0	PIK3C2A, KITLG, SELE, VIM, NAT2, LEP
17	rolipram³² ⁴²	14.0	PDE3B, PDE4A, SELE, SELL, ITGAM, ITGB2
18	capsaicin³²	13.0	CNR1, SELE, VIP, CMA1, BDNF, LEP
19	ionomycin³²	12.8	BTK, CD2, CD69, CD70, CD40, GRP
20	butyrate³²	12.7	KITLG, VIM, BCL2, LGALS3, LEP, MUC1
21	methionine³²	12.7	VIM, LIF, BDNF, LBR, LALBA, S100A9
22	threonine³²	12.6	REL, BTK, AVP, FRS2, CD4, IL1RAPL2
23	thyroxine³² ¹⁸	13.6	PIK3C2A, VIP, BGLAP, LEP, CIITA, CD79A
24	polyinosinic-polycytidylic acid³²	12.5	SELE, VCAM1, CIITA, CD83, CD40, IL10
25	12-o-tetradecanoylphorbol 13-acetate³²	12.5	LIF, LBR, CD4, CD34, CDH1, IVL
26	chloroquine³² ³⁴ ⁹ ⁹	15.5	CIITA, CD79A, CD4, CDH1, ITGAM, IL10
27	choline³² ⁹ ¹⁸ ⁹	15.2	PIK3C2A, VIM, VIP, LIF, BDNF, S100B
28	n-formylmethionyl-leucylphenylalanine³²	12.1	SELL, SELP, MPO, ITGAM, ITGB2, FPR2
29	tuberculin³²	12.1	LBR, CD79A, CD69, CD14, CD40LG, MIF
30	estradiol³² ⁹ ¹⁸ ⁹	15.1	KITLG, VIM, LIF, BDNF, MUC1, CFLAR
31	budesonide³² ⁴² ⁹ ⁹	15.0	PDE4A, KITLG, SFTPD, BGLAP, CD36, IL5RA
32	ifn-alpha³²	11.9	LIF, MX1, IL10, IL13, IL17A, IL18
33	aprotinin³² ⁹ ⁹	13.7	SELP, VIP, LALBA, MMP13, MMP2, MMP9
34	valine³²	11.7	VIM, VIP, BDNF, S100B, MPO, GSTM1
35	hirudin³²	11.6	SELL, F5, F2RL1, TBXA2R, PLAU, PLAUR
36	polyethylene glycol³²	11.5	KITLG, SELE, VIP, MUC1, LALBA, MPO
37	folate³²	11.5	SELE, VIM, NAT1, NAT2, VCAM1, MUC1
38	alpha tocopherol³²	11.5	VCAM1, LIF, BGLAP, LEP, CD36, ITGAM
39	ceramide³²	11.5	PDE3B, CNR1, ASAH2, ANXA5, MAPK1, CASP1
40	fluvastatin³² ³⁴ ⁹ ⁹	14.4	PIK3C2A, SELP, VCAM1, CD40, MMP1, MMP9
41	agar³²	11.3	KITLG, VIM, MUC1, CD40LG, CD34, CDH1
42	quercetin³² ⁴² ⁹ ¹⁸ ⁹	15.3	PIK3C2A, SELE, VCAM1, BCL2, JUN, GSTP1
43	hematoxylin³²	11.0	VIM, LGALS3, MUC1, S100A1, S100B, CD34
44	opiate³²	10.9	GRP, CCR5, CCR3, F2RL1, GNAI1, HRH1
45	gf 109203x³² ⁴²	11.6	KITLG, BTK, VEGFA, JUN, IVL, MMP1
46	5fluorouracil³²	10.5	KITLG, SELE, VEGFA, LIF, BCL2, MUC1
47	acetaldehyde³² ¹⁸	11.4	VIM, CDH1, IL10, IL4, APOA1, APOE
48	tamoxifen³² ³⁴ ⁹ ⁹	13.4	PDE4A, SELE, VIM, VEGFA, VCAM1, BGLAP
49	lactate³²	INF	PIK3C2A, KITLG, SFTPD, BTD, SELE, SELL
50	creatinine³²	INF	KITLG, SELE, SELL, SELP, BDNF, LEP

GO Terms for genes affiliated with Dermatitis

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Sources:
¹²Gene Ontology
See all sources

Cellular components related to dermatitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	21.2	DCD, C3, ADM2, EPO, GAST, NELL2
2	extracellular space	GO:005615	20.8	IL5, CCL11, CCL20, CCL17, CCL1, CCL28
3	plasma membrane	GO:005886	18.8	CCR10, HLA-A, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
4	integral to plasma membrane	GO:005887	14.8	TBXA2R, CX3CR1, CXCR3, CSF2RA, SLC17A5, SLC6A4
5	external side of plasma membrane	GO:009897	14.5	SELL, SELP, VCAM1, MS4A2, CD79A, CD2
6	cytosol	GO:005829	12.6	PLA2G4D, PLA2G6, NOD1, NOD2, NLRC4, NLRP1
7	cornified envelope	GO:001533	11.6	CST6, TGM1, SPRR1B, SPRR1A, HRNR, LOR
8	cell surface	GO:009986	11.6	ELANE, NGFR, NOD2, PLAUR, PLAU, HBEGF

Biological processes related to dermatitis according to GeneDecks:

(show top 50) (show all 69)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	18.6	NCR3, SERPINB4, LIF, CIITA, CD70, CD86
2	inflammatory response	GO:006954	17.9	NCR3, RELA, SELE, SELP, CHI3L1, S100A8
3	signal transduction	GO:007165	15.4	NCR1, NCR2, PDE4A, KITLG, MX1, LALBA
4	cell-cell signaling	GO:007267	14.6	LALBA, S100A9, AVP, CD70, CD86, CD80
5	chemotaxis	GO:006935	14.4	S100A8, S100A9, KAL1, FPR2, IL4, MAPK1
6	cell adhesion	GO:007155	14.1	KITLG, SELL, SELP, VCAM1, CLDN1, BGLAP
7	innate immune response	GO:045087	13.5	RELA, SFTPD, BTK, SERPING1, BCL2, LGALS3
8	defense response to bacterium	GO:042742	13.5	LALBA, S100A14, IL10, CCL20, IFNG, CAMP
9	cytokine-mediated signaling pathway	GO:019221	13.0	RELA, VCAM1, LIFR, CIITA, MX1, IRAK3
10	G-protein coupled receptor signaling pathway	GO:007186	12.8	VIP, MS4A2, FRS2, FPR2, IL8, APOA1
11	positive regulation of NF-kappaB transcription factor activity	GO:051092	12.7	RELA, BTK, CD40, IRAK3, IL1B, IL6
12	response to hypoxia	GO:001666	12.6	VEGFA, VCAM1, BCL2, LEP, MMP9, IL18
13	epidermis development	GO:008544	12.5	ZNF750, BTD, LCE2B, SATB1, S100A7, ATP2A2
14	anti-apoptosis	GO:006916	12.5	RELA, BDNF, BCL2, BCL2A1, MUC1, CFLAR
15	defense response	GO:006952	12.4	MX1, MPO, CD84, CD83, MICU1, IL31RA
16	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	12.4	REL, RELA, S100A4, S100B, CFLAR, CD36
17	keratinization	GO:031424	12.4	CNFN, LCE2B, LCE3A, LCE3B, LCE3C, LCE5A
18	response to lipopolysaccharide	GO:032496	12.3	CNR1, SELE, SELP, S100A14, S100A7, S100A8
19	positive regulation of tumor necrosis factor production	GO:032760	12.2	CD36, CD14, IL12B, IL18, IL23A, CCL3
20	response to drug	GO:042493	12.2	PDE4A, BGLAP, BDNF, BCL2, JUN, CDH1
21	positive regulation of interferon-gamma production	GO:032729	12.1	CD40LG, IL12A, IL12B, IL12RB1, IL12RB2, IL18
22	positive regulation of inflammatory response	GO:050729	12.1	IL12B, IL15, IL18, IL1RL1, IL2, IL23A
23	negative regulation of growth of symbiont in host	GO:044130	12.1	CD36, IL10, IL12B, MBL2, IFNG, CAMP
24	elevation of cytosolic calcium ion concentration	GO:007204	12.0	AVP, IL1B, IL2, CCR6, CCR10, CCR4
25	positive regulation of ERK1 and ERK2 cascade	GO:070374	12.0	CHI3L1, S100A7, MIF, IL1A, IL1B, CCL3
26	negative regulation of apoptotic process	GO:043066	12.0	RELA, VEGFA, BCL11B, BCL2, LEP, AVP
27	positive regulation of interleukin-12 production	GO:032735	11.9	CD36, CD40LG, CD40, IL12B, IL23A, CCR7
28	defense response to Gram-positive bacterium	GO:050830	11.9	CD36, MMP7, IL12A, IL6, MBL2, CAMP
29	cellular response to tumor necrosis factor	GO:071356	11.8	RELA, CHI3L1, IL18, IL8, APOB, CCL2
30	positive regulation of angiogenesis	GO:045766	11.8	VEGFA, CHI3L1, CD34, MMP9, IL1A, IL1B
31	positive regulation of cell proliferation	GO:008284	11.8	VIP, VEGFA, LIF, LIFR, LEP, AVP
32	regulation of immune response	GO:050776	11.8	KIR3DL2, SELL, VCAM1, CD3D, CD8A, CD3G
33	cell surface receptor signaling pathway	GO:007166	11.7	LIFR, CD2, CD36, CD3D, CD14, CD3G
34	blood coagulation	GO:007596	11.7	PDE3B, SELL, SELP, SERPING1, VEGFA, ATP2A2
35	response to ethanol	GO:045471	11.7	CNR1, BGLAP, BCL2, S100A8, S100A9, AVP
36	apoptotic process	GO:006915	11.7	SGPL1, BTK, SEMA3A, VIM, BCL2, BCL2A1
37	cellular response to interleukin-1	GO:071347	11.6	RELA, CHI3L1, MMP9, IL17A, IL8, CCL2
38	leukocyte migration	GO:050900	11.6	SELL, SELP, CD2, CD34, CD84, ITGA6
39	platelet activation	GO:030168	11.5	SELP, SERPING1, VEGFA, CD36, CD40LG, CD40
40	chemokine-mediated signaling pathway	GO:070098	11.5	CCR6, CCL2, CCR4, CCRL1, CCR5, CCR3
41	cellular defense response	GO:006968	11.4	NCR1, NCR2, RELA, KIR3DL2, CD5L, CD160
42	virus-host interaction	GO:019048	11.4	RELA, VIM, NACA, VCAM1, CLDN1, SATB1
43	positive regulation of interleukin-10 production	GO:032733	11.4	CD40LG, CD34, CD83, IL12B, IL23A, IL4
44	defense response to Gram-negative bacterium	GO:050829	11.3	SELP, S100A7, CD4, MMP7, IL12B, IL23A
45	platelet degranulation	GO:002576	11.3	SELP, SERPING1, VEGFA, CD36, APOA1, IGF1
46	defense response to virus	GO:051607	11.2	RELA, BCL2, CD86, CD40, IL12B, IL6
47	cellular response to lipopolysaccharide	GO:071222	11.1	CD36, CD14, GSTP1, IL10, IL12B, IL8
48	positive regulation of smooth muscle cell proliferation	GO:048661	11.1	JUN, IL13, IL6, CCL5, IGF1, HMOX1
49	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	10.9	IL12B, IL2, IL23A, IL3, IL31RA, IL4
50	extracellular matrix disassembly	GO:022617	10.9	CMA1, MMP1, MMP10, MMP13, MMP2, MMP3

Molecular functions related to dermatitis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	14.7	CSF3, CSF2, CXCL9, TSLP, EDN1, LTA
2	chemokine activity	GO:008009	13.7	CXCL9, CCL22, CCL27, CCL26, CCL7, CCL4
3	receptor binding	GO:005102	13.1	NTF3, TNFSF18, TNFSF13B, TNFSF13, TNFSF12, TNC
4	receptor activity	GO:004872	12.3	NGFR, PLAUR, DARC, F2RL1, ABP1, TLR1
5	calcium ion binding	GO:005509	12.3	ABP1, EGF, C1R, HRNR, CALB2, ANXA2
6	protein homodimerization activity	GO:042803	12.2	ABP1, SHBG, PDGFC, NFKB1, NLRC4, NOD1
7	growth factor activity	GO:008083	12.0	IL9, IGF1, NTF3, NTF4, PPBP, NGF
8	transmembrane signaling receptor activity	GO:004888	11.1	NGFR, KLRC1, EGFR, TLR1, TLR2, TLR4
9	tumor necrosis factor receptor binding	GO:005164	11.0	TNFSF18, TNFSF13B, TNFSF13, TNFSF12, TNF, CASP8
10	chemokine receptor activity	GO:004950	10.7	CXCR3, CXCR1, CX3CR1, DARC, CCR3, CCR5
11	protein binding	GO:005515	INF	GAP43, ORM1, PSMB9, PSIP1, STAT6, STAT3