MCID: DRM006
MIFTS: 66

Dermatitis malady

Skin diseases category
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Summaries for Dermatitis

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Wikipedia:65 Dermatitis (from Greek ????? derma \"skin\" and -???? -itis \"inflammation\") or eczema (Greek: ??????... more...

MalaCards based summary: Dermatitis, also known as skin inflammation nos, is related to contact dermatitis and allergic contact dermatitis. An important gene associated with Dermatitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are OX40 Pathway and Cytokines and Inflammatory Response. The drugs clobetasol and cod liver oil and the compounds salmeterol and histamine dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Dermatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
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Dermatitis, Aliases & Descriptions:

Name: Dermatitis 8 10 44 62
 
Skin Inflammation Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Related Diseases for Dermatitis

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Diseases related to Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 622)
idRelated DiseaseScoreTop Affiliating Genes
1contact dermatitis32.6FLG
2allergic contact dermatitis31.7FLG, CCL27, IL5, CXCR3, CCR4
3asthma31.4IL13, CCL11
4eczema herpeticum31.3IGHE
5atopic dermatitis31.2IGHE, CCL27, HRH1, KLK7, IL13, IL5
6folliculitis31.1CCL11
7conjunctivitis31.0HRH1, IGHE
8cutaneous t cell lymphoma30.9CXCR3, IL5, CCR4
9food allergy30.8IL13, IL5, CCL11, IGHE
10lichen planus30.8CXCR3, FLG
11egg allergy30.7IL5, IGHE
12psoriasis30.7CCR4, FLG, IL5, CCL11, KLK7, CXCR3
13keratoconjunctivitis30.7IL5, CCL11, IL13
14bullous pemphigoid30.7CCL11, IL5, FLG, IGHE, IL13
15atopy30.6FLG, CXCR3, IGHE, IL13, CCL11, IL5
16netherton syndrome30.6IGHE, KLK7
17mycosis fungoides30.5CXCR3, CCL27, IL5, CCR4
18malaria30.5HRH1
19cutaneous leishmaniasis30.4IL5, IL13
20bronchitis30.4CCL11, IL5, IGHE
21angioedema30.4HRH1, IGHE, IL5
22rhinitis30.4IL13, CCL11, IL5, IGHE, HRH1
23sarcoidosis30.3CCR4, IL13, CCL11, CXCR3
24eosinophilic gastroenteritis30.3CCL11, IGHE, IL5
25eosinophilia30.3CCR4, CCL11, IL5, CCL27, IL13, IGHE
26schistosomiasis30.2IL13, IGHE, IL5
27skin disease30.2IGHE, CXCR3, CCL11, CCL27, IL13, KLK7
28leishmaniasis30.2IL5, IL13
29rheumatoid arthritis30.2CCR4, CXCR3, FLG, CCL27, IL13, HRH1
30strongyloidiasis30.2IL5, IGHE
31mastocytosis30.1IL5, IL13, IGHE
32allergic bronchopulmonary aspergillosis30.1IL5, IGHE
33allergic rhinitis30.1HRH1, IGHE, CCL11, IL5, IL13
34hypereosinophilic syndrome30.1IL5, CCL11, IGHE
35uveitis30.0CCL11, CCR4, CXCR3
36chronic obstructive pulmonary disease30.0IL13, CCL11, CCR4, CXCR3
37otitis media30.0IGHE, CCL11
38respiratory failure30.0CCL11, IL13, IGHE
39pneumonia29.9CCL11, IL13, IL5, HRH1
40allergic conjunctivitis29.9IL5, IGHE, IL13, HRH1, CCL11
41helminthiasis29.9IGHE, IL5, IL13
42allergic asthma29.9IL13, CCL11, FLG, CCR4, HRH1, IL5
43pulmonary fibrosis29.8CXCR3, CCR4, IL13
44vernal keratoconjunctivitis29.6IGHE, CCL11, CXCR3, IL5, IL13
45ipex syndrome29.6CCL27, CXCR3, CCL11, CCR4, IGHE
46multiple sclerosis29.4CXCR3, IL5, CCL27, CCL11, CCR4, IL13
47dermatitis herpetiformis11.1
48exfoliative dermatitis10.9
49occupational dermatitis10.9
50granulomatous dermatitis10.8

Graphical network of the top 20 diseases related to Dermatitis:



Diseases related to dermatitis

Symptoms for Dermatitis

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Drugs & Therapeutics for Dermatitis

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Genetic Tests for Dermatitis

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Anatomical Context for Dermatitis

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MalaCards organs/tissues related to Dermatitis:

32
Skin, T cells, Testes, Neutrophil, Monocytes, Colon, Liver, Thyroid, Breast, Thymus, B cells, Endothelial, Bone, Eye, Small intestine, Lung, Whole blood, Heart, Tongue, Lymph node, Spinal cord, Tonsil, Myeloid, Pituitary, Bone marrow, Brain, Kidney, Nk cells, Appendix, Pancreatic islet

Animal Models for Dermatitis or affiliated genes

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MGI Mouse Phenotypes related to Dermatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.6FLG, CXCR3, CCR4, CCL11, IL5, IL13
2MP:00053878.1HRH1, IGHE, FLG, ADH5, CXCR3, CCR4

Publications for Dermatitis

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Articles related to Dermatitis:

(show top 50)    (show all 4540)
idTitleAuthorsYear
1
Cases of occupational dermatitis and asthma in beauticians that were reported to The Health and Occupation Research (THOR) network from 1996 to 2011. (24934913)
2014
2
Human I^-defensin-2 as a marker for disease severity and skin barrier properties in atopic dermatitis. (23647067)
2013
3
Inhibitory effects of Juglans mandshurica leaf on allergic dermatitis-like skin lesions-induced by 2,4-dinitrochlorobenzene in mice. (24252297)
2013
4
IL-17 expression in dermatitis herpetiformis and bullous pemphigoid. (23970818)
2013
5
Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model. (23149290)
2013
6
Serum visfatin levels in patients with atopic dermatitis and cutaneous T-cell lymphoma. (24001451)
2013
7
Laser Recall Dermatitis. (24336981)
2013
8
Allergic contact dermatitis due to epsilon-aminocaproic acid: a case report and mini-review of the published work. (23398202)
2013
9
Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice. (23918359)
2013
10
A field trial of infrared thermography as a non-invasive diagnostic tool for early detection of digital dermatitis in dairy cows. (24389042)
2013
11
Allergic contact dermatitis caused by Hedera helix arborescens and not by Hedera helix L. (22568849)
2012
12
Effect of bathing on atopic dermatitis during the summer season. (23130333)
2012
13
Impact of interactive web-based education with mobile and email-based support of general practitioners on treatment and referral patterns of patients with atopic dermatitis: randomized controlled trial. (23249479)
2012
14
Management of dermatitis herpetiformis. (22560140)
2012
15
Interstitial granulomatous dermatitis? An unusual presentation in the mucosa and periungual skin. (21352283)
2011
16
Allergic contact dermatitis following ocular use of corticosteroids. (21265627)
2011
17
Acute haemorrhagic conjunctivitis epidemics and outbreaks of Paederus spp. keratoconjunctivitis ('Nairobi red eyes') and dermatitis. (21920128)
2011
18
Kaposi's sarcoma in an atopic dermatitis patient: a case report and a review of literature. (21385206)
2011
19
Systemic allergic contact dermatitis to black cumin essential oil expressing as generalized erythema multiforme. (21524993)
2011
20
Allergic contact dermatitis from N,N-methylenebismorpholine in a cutting oil. (20920419)
2010
21
In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. (20805398)
2010
22
Number of flocks on the same litter and carcase condemnations due to cellulitis, arthritis and contact foot-pad dermatitis in broilers. (21058060)
2010
23
A rare case of allergic contact dermatitis from silver nitrate in a widely used special patch test marker. (19706054)
2009
24
Generalized erythema multiforme after localized allergic dermatitis from dark henna tattoo. (19689544)
2009
25
Contact irritant dermatitis from insect secretions: report of 74 cases in a military unit in Eritrea. (19731793)
2009
26
Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3. (18538383)
2008
27
Bartonella-associated meningoradiculoneuritis and dermatitis or panniculitis in 3 dogs. (18466250)
2008
28
Occupational dermatitis in a hairdresser. (17717371)
2007
29
Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. (15944307)
2005
30
Inflammatory mediators in patients with atopic dermatitis after treatment with transfer factor]. (15491080)
2004
31
Effect of staphylococcal enterotoxin B on specific antibody production in children with atopic dermatitis. (12635580)
2003
32
Soluble E-selectin correlates with disease activity in cyclosporin A-treated patients with atopic dermatitis. (10195358)
1999
33
Tissue transglutaminase antibodies in dermatitis herpetiformis. (10490368)
1999
34
Acute inflammatory demyelinating polyradiculoneuropathy associated with hyperIgEemia and atopic dermatitis. (9562273)
1998
35
Occupational dermatitis due to formaldehyde in newspaper. (9330824)
1997
36
Resolution of exfoliative dermatitis and Malassezia pachydermatis overgrowth in a cat after surgical thymoma resection. (9358405)
1997
37
Chronic actinic dermatitis. An immunohistochemical study of its T-cell antigenic profile, with comparison to cutaneous T-cell lymphoma. (7802165)
1994
38
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
39
Systemic interferon gamma treatment in severe atopic dermatitis. (8315079)
1993
40
Photosensitivity dermatitis and actinic reticuloid syndrome (chronic actinic dermatitis). (2203443)
1990
41
Manic depression induced by dapsone in patient with dermatitis herpetiformis. (2510873)
1989
42
Occupational dermatitis to Ampholyt G in hospital personnel. (6222878)
1983
43
Video computer terminals and occupational dermatitis. (6458886)
1981
44
Cercarial dermatitis. (4412365)
1974
45
Exfoliative dermatitis and generalized erythroderma. (4257634)
1969
46
Hypothermia in patients with exfoliative dermatitis. (13754513)
1960
47
Allergic occupational dermatitis. (13336265)
1956
48
Exfoliative dermatitis after undecylenic acid therapy for psoriasis. (14774148)
1950
49
Exfoliative dermatitis; classification, diagnosis and treatment. (20252104)
1947
50
Exfoliative dermatitis following penicillin therapy. (20999603)
1946

Variations for Dermatitis

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Expression for genes affiliated with Dermatitis

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Expression patterns in normal tissues for genes affiliated with Dermatitis

Search GEO for disease gene expression data for Dermatitis.

Pathways for genes affiliated with Dermatitis

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Pathways related to Dermatitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL13, IL5
210.1IL5, IL13
310.1IL13, IL5
49.7IL5, CCL11, IGHE
5
Show member pathways
9.4CXCR3, CCR4, CCL11, CCL27
6
Show member pathways
9.4CCL27, CCL11, CCR4, CXCR3
7
Show member pathways
9.4CCL27, CCL11, CCR4, CXCR3
8
Show member pathways
9.2CXCR3, CCR4, CCL11, CCL27, HRH1
9
Show member pathways
9.0CXCR3, CCR4, CCL11, CCL27, IL5, IL13
10
Show member pathways
9.0IL5, CCL27, CCL11, CCR4, CXCR3, IL13
11
Show member pathways
9.0CXCR3, CCR4, CCL11, CCL27, IL5, IL13
12
Show member pathways
8.8NACA, CXCR3, CCR4, CCL11, CCL27, IL5

Compounds for genes affiliated with Dermatitis

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Compounds related to Dermatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1salmeterol44 50 28 1113.2IL5, CCL11, IL13
2histamine dihydrochloride6110.2DHX8, DHX34, HRH1
32-pyridylethylamine dihydrochloride6110.2HRH1, DHX8, DHX34
4mepyramine maleate6110.2DHX34, DHX8, HRH1
5clemastine fumarate6110.2DHX8, HRH1, DHX34
6ltc44410.1CCL11, IL13, IL5
7unicap4410.1IGHE, IL5, CCL11
8ltd44410.1HRH1, IL5, IL13
9astemizole44 61 28 1113.1HRH1, DHX8, DHX34
10groalpha4410.1IL13, CCL11, CXCR3
11omalizumab44 1111.1IL5, IL13, IGHE
12trimellitic anhydride4410.1IGHE, IL13
13anti-histamine4410.1CCL11, IGHE, HRH1
14nickel44 2411.1IL13, FLG, IL5
15oxatomide4410.1HRH1, IL5, IGHE
16ovomucoid4410.1IGHE, IL13, IL5
17praziquantel44 1111.0IL5, IGHE, IL13
18nedocromil sodium4410.0IGHE, IL5, HRH1
19desloratadine44 1111.0IGHE, IL13, HRH1
20methyltetrahydrophthalic anhydride4410.0IL13, IGHE
21penicillin4410.0IGHE, IL5, IL13
22sodium cromoglycate449.9HRH1, CCL11, IL5, IGHE
23cetirizine44 28 24 1112.9CCL11, IGHE, HRH1, IL5
24montelukast44 50 28 1112.9IL5, IL13, CCL11, IGHE
25ketotifen44 1110.9IGHE, HRH1, IL5, CCL11
26budesonide44 50 1111.9CCL11, IL13, IGHE, IL5
27azelastine44 1110.9IL5, HRH1, IGHE
28salbutamol44 50 28 24 1113.9CCL11, IGHE, IL13, IL5
29fluticasone propionate44 50 61 1112.9IL13, IGHE, IL5, CCL11
30pgd2449.9IL5, CCL11, IL13, IGHE
31methacholine44 50 1111.9IL13, CCL11, IL5, IGHE
32tacrolimus44 50 1111.9HRH1, IL13, CCL11, CXCR3, IL5
33fmlp449.7CCL11, IL13, CXCR3, IL5
34hydrocortisone44 2 61 1112.7IGHE, CXCR3, IL5, IL13
35endotoxin449.7CXCR3, HRH1, CCL11, IL13
36ccl344 2810.6CXCR3, CCR4, CCL11, CCL27, IL13
37ccl444 2810.6IL13, CCL27, CCR4, CXCR3, CCL11
38prednisolone44 28 1111.6CCL11, IL5, IL13, IGHE, CCR4
39indomethacin44 28 61 1112.6HRH1, IGHE, CCL11, IL5, IL13
40histamine44 28 2411.5IGHE, HRH1, IL13, CXCR3, IL5, CCL11
41pge2449.5HRH1, CXCR3, CCL27, IL5, CCL11, IL13
42cyclosporin a44 28 6111.4IL13, HRH1, IGHE, IL5, CCL11
43isoproterenol44 1110.4IL13, IL5, HRH1, IGHE
44rantes449.2IL13, IL5, CCL11, CCR4, CXCR3, HRH1
45arginine449.2IGHE, IL13, IL5, DHX8, CXCR3, ADH5
46dexamethasone44 50 28 1112.1CCL27, CXCR3, IGHE, IL13, HRH1, IL5
47tarc449.1CCL27, IL13, IL5, CCR4, CXCR3, IGHE
48nitric oxide44 24 1111.1FLG, HRH1, CCL11, IL13, CXCR3, ADH5
49retinoic acid44 2410.0KLK7, ADH5, IL13, IL5, CCL11, CCR4
50allergens449.0IL5, CCL27, CCL11, IL13, CXCR3, HRH1

GO Terms for genes affiliated with Dermatitis

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Cellular components related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.7IL13, CCR4, CXCR3
2extracellular regionGO:0055768.7KLK7, IL13, IL5, CCL27, CCL11, IGHE

Biological processes related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.0HRH1, CCL11
2response to radiationGO:00931410.0CCL11, CCR4
3positive regulation of release of sequestered calcium ion into cytosolGO:0512819.8IL13, CXCR3
4chemotaxisGO:0069359.4CXCR3, CCR4, CCL11, CCL27
5inflammatory responseGO:0069549.3HRH1, IL13, IL5, CCL11, CCR4, CXCR3
6immune responseGO:0069558.9IGHE, CCR4, CCL11, CCL27, IL5, IL13

Molecular functions related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.9CCR4, CXCR3

Products for genes affiliated with Dermatitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet