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MCID: DRM006
MIFTS: 68

Dermatitis malady

Skin diseases category
27 drugs, 634 genes, 29 tissues, 550 related diseases, clinical trials.

Summaries for Dermatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Dermatitis (from Greek δέρμα derma \"skin\" and -ῖτις -itis \"inflammation\") or eczema... more...

MalaCards: Dermatitis, also known as other chronic dermatitis due to solar radiation, is related to atopic dermatitis and contact dermatitis. An important gene associated with Dermatitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are Rho Family GTPases and Akt Signaling. The drugs clobetasol and cod liver oil and the compounds allergens and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes.

Aliases & Classifications for Dermatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases
ICD10: 25


Aliases & Descriptions:

dermatitis 8 10 44 60
other chronic dermatitis due to solar radiation 8
other dermatitis due to solar radiation 8
skin inflammation nos 8
dermatitis, nos 8
dermatitis nos 8


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Disease Ontology8 DOID:2723
NCIt39 C2983
MeSH34 D003872
ICD1025 L30

Related Diseases for Dermatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 550)
idRelated DiseaseScoreTop Affiliating Genes
1atopic dermatitis32.0KLK7, CCL11, CCR4, CCL27, FLG, IGHE
2contact dermatitis31.8FLG
3allergic contact dermatitis31.6CCL27
4psoriasis31.1KLK7, CCL11, CCR4, CCL27, FLG, CXCR3
5skin disease30.8KLK7, CCL11, CCL27, FLG, IGHE, CXCR3
6asthma30.8IL5, IGHE
7arthritis30.7CXCR3, FLG
8eczema herpeticum30.6IGHE
9food allergy30.5CCL11, IGHE, IL5
10urticaria30.5HRH1, IGHE
11bullous pemphigoid30.5CCL11, FLG, IGHE, IL5
12cutaneous t cell lymphoma30.4CCR4, CXCR3, IL5
13rheumatoid arthritis30.4CCL11, CCR4, CCL27, FLG, CXCR3, HRH1
14eosinophilia30.4CCL11, CCR4, CCL27, IGHE, IL5
15allergic asthma30.3CCL11, CCR4, FLG, IGHE, IL5, HRH1
16mycosis fungoides30.3IL5, CXCR3, CCL27, CCR4
17folliculitis30.2CCL11
18rhinitis30.2HRH1, IL5, IGHE, CCL11
19conjunctivitis30.2HRH1, IGHE
20keratoconjunctivitis30.2IL5, CCL11
21egg allergy30.1IGHE, IL5
22allergic rhinitis30.1CCL11, CCR4, FLG, IGHE, CXCR3, IL5
23sarcoidosis30.0CXCR3, CCR4, CCL11
24netherton syndrome30.0IGHE, KLK7
25allergic conjunctivitis29.9CCL11, IGHE, IL5, HRH1
26bronchitis29.9CCL11, IGHE, IL5
27angioedema29.9HRH1, IL5, IGHE
28eosinophilic gastroenteritis29.8CCL11, IGHE, IL5
29onchocerciasis29.8IL5
30ipex syndrome29.5CCL11, CCR4, CCL27, IGHE, CXCR3
31uveitis29.5CCL11, CCR4, CXCR3
32pulmonary eosinophilia29.5IL5, IGHE, CCL11
33pneumonia29.5HRH1, IL5, CCL11
34strongyloidiasis29.5IL5, IGHE
35otitis media29.5CCL11, IGHE
36allergic bronchopulmonary aspergillosis29.5IL5, IGHE
37churg-strauss syndrome29.5IL5
38malaria29.5HRH1
39tuberculosis29.5CXCR3, CCR4
40dermatitis herpetiformis11.1
41occupational dermatitis11.0
42irritant dermatitis10.8
43granulomatous dermatitis10.8
44cercarial dermatitis10.6
45contagious pustular dermatitis10.5
46erythema multiforme10.5
47seborrheic infantile dermatitis10.5
48celiac disease10.4
49lupus erythematosus10.4
50photoallergic dermatitis10.4

Graphical network of the top 20 diseases related to Dermatitis:



Diseases related to dermatitis

Clinical Features for Dermatitis

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Drugs & Therapeutics for Dermatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dermatitis

Drug clinical trials:

Search ClinicalTrials for Dermatitis

Search NIH Clinical Center for Dermatitis

Search CenterWatch for Dermatitis

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Dermatitis

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Anatomical Context for Dermatitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Dermatitis:

32
Skin, T cells, Testes, Monocytes, Liver, Colon, Thyroid, Thymus, Breast, Endothelial, B cells, Bone, Eye, Lung, Small intestine, Whole blood, Heart, Tongue, Tonsil, Spinal cord, Pituitary, Myeloid, Brain, Kidney, Lymph node, Bone marrow, Nk cells, Appendix, Pancreatic islet

Animal Models for Dermatitis or affiliated genes

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Publications for Dermatitis

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Sources:
50PubMed
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Articles related to Dermatitis:

(show top 50)    (show all 4446)
idTitleAuthorsYear
1
Hexavalent chromium in leather is now regulated in European Union member states to limit chromium allergy and dermatitis. (24341467)
2014
2
Oxytocin modulates proliferation and stress responses of human skin cells: implications for atopic dermatitis. (23711064)
2013
3
A holistic view on dermatitis: patch testing should be considered in patients with atopic dermatitis. (23810760)
2013
4
Sensor-based monitoring of the prevalence and severity of foot pad dermatitis in broiler chickens. (24066948)
2013
5
Increased expression of gelatinase and caspase activities in the skin of NC/Tnd mice: a model for atopic dermatitis. (24030366)
2013
6
Contact dermatitis caused by iodopropynyl butylcarbamate inA Denmark. (23869727)
2013
7
A prospective two-year assessment of miconazole resistance in Candida spp. With repeated treatment with 0.25% miconazole nitrate ointment in neonates and infants with moderate to severe diaper dermatitis complicated by cutaneous candidiasis. (23675632)
2013
8
Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency. (22322004)
2012
9
Multicenter study of preservative sensitivity in patients with suspected cosmetic contact dermatitis in Korea. (22548403)
2012
10
Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population. (22222815)
2012
11
Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice. (21821914)
2011
12
Polyurethane toilet seat contact dermatitis. (21575050)
2011
13
Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay. (21285510)
2011
14
Deodorants are the leading cause of allergic contact dermatitis to fragrance ingredients. (21480912)
2011
15
Allergic contact dermatitis from N,N-methylenebismorpholine in a cutting oil. (20920419)
2010
16
Allergic contact dermatitis from carvone in hair conditioners. (20233552)
2010
17
Uncombable hair and atopic dermatitis in a case of trichodento-osseous syndrome. (20151948)
2010
18
Histamine H(4) receptor antagonist ameliorates chronic allergic contact dermatitis induced by repeated challenge. (19886918)
2010
19
IL-23 and T(H)17-mediated inflammation in human allergic contact dermatitis. (18986691)
2009
20
Recurrent cyclic hyperkeratotic eczema after occupational alkali burn: traumatic chronic irritant dermatitis. (19489972)
2009
21
Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. (19733298)
2009
22
R501X and 2282del4 filaggrin mutations do not confer susceptibility to psoriasis and atopic dermatitis in Italian patients. (18032906)
2008
23
Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers. (19116453)
2008
24
Extensive exfoliative dermatitis induced by non-ionic contrast medium Iodixanol (Visipaque) used during percutaneous coronary intervention. (17336410)
2008
25
Allergic contact dermatitis mimicking mammary paget's disease. (19882019)
2008
26
Childhood dermatitis herpetiformis: a case report and review of the literature. (18246879)
2007
27
Dermatitis herpetiformis and rheumatoid arthritis. (17457505)
2007
28
Pyoderma gangrenosum masquerading as dermatitis artefacta. (17116850)
2006
29
Analysis of IFN-kappa expression in pathologic skin conditions: downregulation in psoriasis and atopic dermatitis. (16542135)
2006
30
Erythema elevatum diutinum arising in the setting of dermatitis herpetiformis. (16983903)
2006
31
Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants. (15693914)
2005
32
Mast cell chymase is increased in chronic atopic dermatitis but not in psoriasis. (15703960)
2005
33
Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear. (11859856)
2002
34
Circulating activation markers of severe atopic dermatitis following ultraviolet A1 cold light phototherapy: eosinophil cationic protein, soluble interleukin-2 receptor and soluble interleukin-4 receptor. (10354046)
1999
35
Soluble E-selectin, other markers of inflammation and disease severity in children with atopic dermatitis. (9580795)
1998
36
Adult coeliac disease, dermatitis herpetiformis and smoking. (9071949)
1997
37
Nutritional content of few foods diet in atopic dermatitis. (7492156)
1995
38
Granulomatous dermatitis and mastitis in two SPF rats associated with a slowly growing Staphylococcus aureus--a case report. (7603004)
1995
39
Exfoliative dermatitis related to omeprazole. (7711353)
1995
40
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
41
Assessment of eosinophil and neutrophil participation in atopic dermatitis: comparison with the IgE-mediated late-phase reaction. (8027490)
1994
42
Asymptomatic anemia in three men with dermatitis herpetiformis. (1560069)
1992
43
Production of interleukin-2 by mononuclear cells in vitro in patients with atopic dermatitis and psoriasis. Comparison with serum interleukin-2 receptor levels. (1684468)
1991
44
Time-course studies of immediate and delayed immune reactivity in patients with atopic dermatitis treated with herbal drugs. (1705106)
1990
45
Dermatitis herpetiformis--what is it? (2196234)
1990
46
Dermatitis herpetiformis in a patient with acquired immunodeficiency syndrome-related complex. (3351018)
1988
47
Occupational dermatitis to Ampholyt G in hospital personnel. (6222878)
1983
48
Exfoliative dermatitis following ingestion of phenylbutazone (butazolidin). (13084438)
1953
49
Periarteritis nodosa; a case of fatal exfoliative dermatitis resulting from dilantin sodium sensitization. (18106254)
1948
50
Lupus Erythematosus cured by Injections of Solganol B which resulted in Generalized Exfoliative Dermatitis from which the patient nearly died. (19989024)
1932

Genetic Variations for Dermatitis

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Expression for genes affiliated with Dermatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dermatitis

Search GEO for disease gene expression data for Dermatitis.

Pathways for genes affiliated with Dermatitis

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Dermatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Rho Family GTPases51
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11.3CCL11, CXCR3, IL5, NACA, CCL27, CCR4
2
Akt Signaling51
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11.2CCL11, CCR4, CCL27, CXCR3, IL5
3
PEDF Induced Signaling51
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11.2CCL11, IL5, CXCR3, CCR4, CCL27
4
PAK Pathway51
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11.2CCL11, IL5, CXCR3, CCL27, CCR4
5
Class A/1 (Rhodopsin-like receptors)53
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11.2CXCR3, CCL27, CCR4, CCL11, HRH1
6
Chemokine Signaling51
Hide members
11.1CXCR3, CCL27, CCR4, CCL11
7
Chemokine receptors bind chemokines53
11.1CCL11, CCR4, CCL27, CXCR3
8
IL4-mediated signaling events37
10.9CCL11, IGHE, IL5

Compounds for genes affiliated with Dermatitis

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Dermatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1allergens4411.9HRH1, IL5, CXCR3, IGHE, FLG, CCL27
2retinoic acid44 2412.9IGHE, FLG, CCR4, CCL11, IL5, ADH5
3tarc4411.8CCL11, CCR4, CCL27, IGHE, IL5, CXCR3
4rantes4411.8HRH1, CCR4, CCL11, CCL27, IL5, CXCR3
5dexamethasone44 49 28 1114.7CCL11, IL5, CXCR3, IGHE, CCL27, HRH1
6arginine4411.7IL5, CXCR3, DHX8, IGHE, FLG, ADH5
7histamine44 28 2413.6IL5, HRH1, IGHE, CCL11, CXCR3
8pge24411.5IL5, CCL11, CCL27, CXCR3, HRH1
9sodium cromoglycate4411.5IGHE, CCL11, IL5, HRH1
10cetirizine44 28 11 2414.5IL5, IGHE, CCL11, HRH1
11ketotifen44 1112.5IGHE, HRH1, IL5, CCL11
12ccl344 2812.5CCL11, CCR4, CXCR3, CCL27
13ccl444 2812.5CXCR3, CCL27, CCR4, CCL11
14prednisolone44 28 1113.5IGHE, IL5, CCR4, CCL11
15tacrolimus44 49 1113.4HRH1, IL5, CCL11, CXCR3
16mepyramine maleate5911.4DHX34, HRH1, DHX8
17histamine dihydrochloride5911.4DHX8, DHX34, HRH1
182-pyridylethylamine dihydrochloride5911.3DHX34, DHX8, HRH1
19clemastine fumarate5911.3HRH1, DHX34, DHX8
20unicap4411.3IGHE, IL5, CCL11
21oxatomide4411.3HRH1, IGHE, IL5
22anti-histamine4411.3IGHE, CCL11, HRH1
23astemizole44 59 28 1114.3DHX8, DHX34, HRH1
24nedocromil sodium4411.3IGHE, IL5, HRH1
25azelastine44 1112.3HRH1, IGHE, IL5
26indomethacin44 59 28 1114.3CCL11, IGHE, IL5, HRH1
27montelukast44 49 28 1114.3IL5, IGHE, CCL11
28budesonide44 49 1113.3IGHE, IL5, CCL11
29salbutamol44 49 28 11 2415.3IL5, CCL11, IGHE
30fluticasone propionate44 49 59 1114.3IGHE, CCL11, IL5
31pgd24411.3IGHE, CCL11, IL5
32infliximab44 49 1113.2IGHE, CXCR3, FLG
33methacholine44 1112.2CCL11, IGHE, IL5
34capsaicin44 2812.2IL5, IGHE, HRH1
35levocetirizine4411.1HRH1, CCL11
36omalizumab44 1112.1IL5, IGHE
37levocabastine44 28 1113.1HRH1, IL5
38beclomethasone dipropionate4411.0IGHE, IL5
39ovomucoid4411.0IL5, IGHE
40lte44411.0IL5, CCL11
41toluene diisocyanate4411.0IL5, IGHE
425-oxoete4411.0IL5, CCL11
43desloratadine44 1111.9HRH1, IGHE
44epinastine44 1111.9IL5, HRH1
45roxithromycin44 28 1112.9IL5, CCL11
46olopatadine44 1111.8HRH1, IGHE
47pranlukast44 28 1112.8CCL11, IL5
48loratadine44 11 2412.8HRH1, IGHE
49fexofenadine44 49 11 2413.7IL5, HRH1
50mcp 14410.5CXCR3, IL5

GO Terms for genes affiliated with Dermatitis

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Sources:
16Gene Ontology
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Biological processes related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.1CCL11, CCR4, CXCR3, IL5, HRH1
2chemotaxisGO:00693511.1CXCR3, CCL27, CCR4, CCL11
3immune responseGO:00695510.9IL5, IGHE, CCL27, CCR4, CCL11
4eosinophil chemotaxisGO:04824510.8HRH1, CCL11

Molecular functions related to Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.8CXCR3, CCR4

Products for genes affiliated with Dermatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet
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