MCID: DRM007
MIFTS: 57

Dermatitis Herpetiformis malady

Skin category

Summaries for Dermatitis Herpetiformis

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Dermatitis herpetiformis (DH), or Duhring\'s disease, is a chronic blistering skin condition,... more...

MalaCards: Dermatitis Herpetiformis, also known as dermatosis herpetiformis, is related to celiac disease and bullous pemphigoid, and has symptoms including malabsorption/chronic diarrhea/steatorrhea, erythema/erythematous lesions/erythroderma/polymorphous erythema and macules. An important gene associated with Dermatitis Herpetiformis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix. The drugs dapsone and sulfapyridine pwdr and the compounds glutamate and gliadin have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and renal/urinary system.

Description from OMIM:47 601230

Aliases & Classifications for Dermatitis Herpetiformis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Characteristics (Orphanet epidemiological data):

49
dermatitis herpetiformis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

dermatitis herpetiformis 8 10 45 49 47 61
dermatosis herpetiformis 8
durhing-brocq disease 49
duhring's disease 8


External Ids:

Disease Ontology8 DOID:8505
ICD9CM27 694.0
NCIt40 C26742
MeSH35 D003874
OMIM47 601230
MESH via Orphanet36 D003874
ICD10 via Orphanet26 L13.0
SNOMED-CT via Orphanet58 111196000
UMLS via Orphanet62 C0011608
ICD1025 L13.0

Related Diseases for Dermatitis Herpetiformis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Dermatitis Herpetiformis family:

juvenile dermatitis herpetiformis dermatitis herpetiformis familial

Diseases related to Dermatitis Herpetiformis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1celiac disease31.2HLA-DQB1, TRB, CD79A, MMP12, TGM2
2bullous pemphigoid31.1CCL11, HLA-DQB1, CD79A, PLAU
3ulcerative colitis30.6CCL11, CD79A, MMP3, MMP7
4arthritis30.5FBN1, TRB, IL2RB, MMP3, MMP12
5pemphigus30.3PLAU, CD79A
6systemic lupus erythematosus30.3HLA-DQB1, FBN1, TRB, CD79A, IL2RB, MMP3
7stevens-johnson syndrome30.1TGM1
8ankylosing spondylitis30.1CD79A
9hepatitis c30.1MMP7
10juvenile dermatitis herpetiformis10.7
11dermatitis herpetiformis familial10.5
12vitiligo10.4
13herpes gestationis10.4
14discoid lupus erythematosus10.4
15sclerosing cholangitis10.3
16urticaria10.3
17primary sclerosing cholangitis10.3
18herpetiform pemphigus10.3
19impetigo herpetiformis10.2
20subcorneal pustular dermatosis10.2
21atrophic gastritis10.2
22primary biliary cirrhosis10.2
23protein-losing enteropathy10.2
24stiff-person syndrome10.2
25anaplastic large cell lymphoma10.2
26duhring brocq disease10.2
27ataxia10.2
28deficiency anemia10.1
29membranous glomerulonephritis10.1
30relapsing polychondritis10.1
31pityriasis rosea10.1
32erythema multiforme10.1
33cutis laxa10.1
34variegate porphyria10.1
35epidermolysis bullosa acquisita10.1
36somatostatinoma10.1
37pancreatic somatostatinoma10.1
38usher syndrome10.1
39psoriatic arthritis10.1
40panhypopituitarism10.1
41cicatricial pemphigoid10.1
42alpha chain disease10.1
43eosinophilic gastroenteritis10.1
44acquired immunodeficiency syndrome10.1
45hepatitis d10.1
46reticulosarcoma10.1
47pyoderma gangrenosum10.1
48tonsillitis10.1
49pernicious anemia10.1
50acne10.1

Graphical network of the top 20 diseases related to Dermatitis Herpetiformis:



Diseases related to dermatitis herpetiformis

Clinical Features for Dermatitis Herpetiformis

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

601230

Clinical synopsis from OMIM:

601230

Symptoms:

49 (show all 15)
  • malabsorption/chronic diarrhea/steatorrhea
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • follicular/erythematous/edematous papules/milium
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • pruritus/itching
  • cutaneous edema
  • mutiple fractures/bone fragility
  • autoimmunity/autoimmune reaction/autoantibodies
  • urticaria
  • microcytic anemia
  • bone pain
  • eczema
  • negative nikolski's sign
  • lichen

Drugs & Therapeutics for Dermatitis Herpetiformis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Dermatitis Herpetiformis

Drug clinical trials:

Search ClinicalTrials for Dermatitis Herpetiformis

Search NIH Clinical Center for Dermatitis Herpetiformis

Search CenterWatch for Dermatitis Herpetiformis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Dermatitis Herpetiformis

Anatomical Context for Dermatitis Herpetiformis

Animal Models for Dermatitis Herpetiformis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Dermatitis Herpetiformis

Sources:
51PubMed
See all sources

Articles related to Dermatitis Herpetiformis:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Clinical and immunopathological features of 159 patients with dermatitis herpetiformis: an Italian experience. (23588141)
2013
2
An Unusual Case of Dermatitis Herpetiformis. (23406540)
2013
3
Negative direct immunofluorescence and nonspecific histology do not exclude the diagnosis of dermatitis herpetiformis Duhring. (23347314)
2013
4
Bullous pemphigoid and dermatitis herpetiformis association: A genetic predisposition. (24128323)
2013
5
Management of dermatitis herpetiformis. (22560140)
2012
6
The association of dermatitis herpetiformis and systemic lupus erythematosus. (20739096)
2010
7
Non-dermatitis herpetiformis gluten-sensitive dermatitis: a personal account of an unrecognized entity. (21284279)
2010
8
Dermatitis herpetiformis: pearls and pitfalls in diagnosis and management. (20708475)
2010
9
Prediction of clinical and mucosal severity of coeliac disease and dermatitis herpetiformis by quantification of IgA/IgG serum antibodies to tissue transglutaminase. (19841593)
2010
10
Might dermatitis herpetiformis be associated with discoid lupus erythematosus? (18482033)
2008
11
Dermatitis herpetiformis presenting as ataxia in a child. (17340026)
2007
12
Medical pearl: Using tissue transglutaminase antibodies to diagnose dermatitis herpetiformis. (16243141)
2005
13
Flare of dermatitis herpetiformis associated with gluten in multivitamins. (15692492)
2005
14
The occurrence of type 1 diabetes in patients with dermatitis herpetiformis and their first-degree relatives. (14746628)
2004
15
Hypothesis: patients with dermatitis herpetiformis may be predisposed to depression and aggression. (15624741)
2004
16
Dermatitis herpetiformis in association with lichen planopilaris. (11862193)
2002
17
Iodine and gliadin challenge on oral mucosa in dermatitis herpetiformis. (12125958)
2002
18
Dermatitis herpetiformis is associated with atrophic but not with goitrous variant of Hashimoto's thyroiditis. (10620002)
2000
19
Antibodies to tissue transglutaminase as serologic markers in patients with dermatitis herpetiformis. (10417632)
1999
20
Dermatitis herpetiformis following gastric surgery. (9006392)
1997
21
Dermatitis herpetiformis occuring in patients with celiac disease in childhood]. (8881298)
1996
22
Failure of intradermal skin testing with gluten to produce delayed hypersensitivity reactions in patients with dermatitis herpetiformis. (7772473)
1995
23
Malignant lymphoma and dermatitis herpetiformis. (8186505)
1994
24
25 years' experience of a gluten-free diet in the treatment of dermatitis herpetiformis. (7947207)
1994
25
The association between coeliac disease, dermatitis herpetiformis and certain HLA-antigens in Icelanders. (9098455)
1994
26
Antibodies to E1b protein-derived peptides of enteric adenovirus type 40 are associated with celiac disease and dermatitis herpetiformis. (7694817)
1993
27
Gamma/delta T-cell receptor expression in the jejunal epithelium of patients with dermatitis herpetiformis and coeliac disease. (8403465)
1993
28
Dermatitis herpetiformis. (1469303)
1992
29
Childhood dermatitis herpetiformis. (1806225)
1991
30
The pathogenesis of dermatitis herpetiformis. (1806218)
1991
31
Gluten-free diet and elemental diet in dermatitis herpetiformis. (2269561)
1990
32
Dermatitis herpetiformis. (2249367)
1990
33
Sulfapyridine and sulfones decrease glycosaminoglycans viscosity in dermatitis herpetiformis, ulcerative colitis, and pyoderma gangrenosum. (2182989)
1990
34
Gastric histology and function tests in Italian patients with dermatitis herpetiformis. (2336546)
1990
35
Similar high frequency of IgA antireticulin and antiendomysial antibodies in dermatitis herpetiformis. (2273136)
1990
36
Manic depression induced by dapsone in patient with dermatitis herpetiformis. (2510873)
1989
37
Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis. (2570807)
1989
38
Dermatitis herpetiformis associated with relapsing polychondritis. (3243370)
1988
39
Dermatitis herpetiformis and hemodialysis. (3678553)
1987
40
Antiendomysial antibody--useful serological indicator of dermatitis herpetiformis. (3435174)
1987
41
Anti-endomysial antibodies. A serologic marker of dermatitis herpetiformis. (3513713)
1986
42
Antigliadin and antireticulin antibodies in children with dermatitis herpetiformis. (3531458)
1986
43
Dermatitis herpetiformis and growth retardation. (3792394)
1986
44
Natural history of dermatitis herpetiformis in southern Sweden. (3817238)
1986
45
IgA anti-endomysial antibody detection in the serum of patients with dermatitis herpetiformis following gluten challenge. (4026376)
1985
46
Male sex hormone status in dermatitis herpetiformis. (3918554)
1985
47
Changes in food consumption and its nutritional quality when on a gluten-free diet for dermatitis herpetiformis. (2991172)
1985
48
Influence of the amount of dietary gluten on gastrointestinal morphology and function in dermatitis herpetiformis. (6469705)
1984
49
Dermatitis herpetiformis: jejunal findings and skin response to gluten free diet. (6742871)
1984
50
Epidermolysis bullosa resembling juvenile dermatitis herpetiformis. (13149726)
1954

Genetic Variations for Dermatitis Herpetiformis

Expression for genes affiliated with Dermatitis Herpetiformis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dermatitis Herpetiformis

Search GEO for disease gene expression data for Dermatitis Herpetiformis.

Pathways for genes affiliated with Dermatitis Herpetiformis

Sources:
38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 12EMD Millipore
See all sources

Compounds for genes affiliated with Dermatitis Herpetiformis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1glutamate4510.8FBN1
2gliadin4510.7TGM2, CD79A
3pge24510.7PLAU, CCL11
4indomethacin45 60 29 1113.6PLAU, EDNRB
5tgm 24510.6TGM3, TGM2
6n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid45 1111.6MMP12, MMP3
7uk 3833676010.5MMP3, MMP12, MMP7
8gi 254023x6010.5MMP3, MMP12, MMP7
9gm 60016010.5MMP3, MMP12, MMP7
10unicap4510.5CD79A, CCL11
11etanercept45 50 1112.5MMP12, MMP3, IL2RB
12marimastat45 60 1112.5MMP3, MMP12, MMP7, PLAU
13batimastat45 60 1112.5MMP3, MMP12, MMP7, PLAU
14prednisolone45 29 1112.4CCL11, CD79A, IL2RB, MMP3
15methacholine45 1111.4IL2RB, CD79A, CCL11
16azathioprine45 50 2 1113.4EDNRB, CD79A, IL2RB, PLAU
17l-glutamine29 11 2412.4TGM1, TGM2, TGM6, TGM3
18sodium dodecylsulfate4510.4FBN1, CD79A, PLAU, TGM1
19hyaluronic acid45 2411.4CCL11, FBN1, CD79A, MMP3, PLAU
20epsilon-(gamma-glutamyl)lysine4510.4TGM1, TGM2
21dexamethasone45 50 29 1113.3CCL11, EDNRB, CD79A, MMP12
22matrigel4510.3CCL11, MMP3, MMP12, MMP7, PLAU
23phorbol4510.3TRB, MMP3, PLAU, TGM1
24histamine45 29 2412.3CCL11, CD79A, IL2RB, MMP3, PLAU
25n acetylcysteine4510.3CCL11, CD79A, IL2RB, MMP3, MMP12, PLAU
26fibrinogen4510.3CD79A, MMP12, MMP7, PLAU, TGM2
27cyclosporin a45 29 6012.3CCL11, EDNRB, TRB, CD79A, IL2RB
28gluten4510.3TGM2, CD79A
29genistein45 29 60 2 11 2415.3CCL11, IL2RB, MMP3, MMP12, PLAU
30dmso4510.2EDNRB, MMP3, MMP7, PLAU
31oxygen45 2411.2CCL11, EDNRB, FBN1, IL2RB, MMP12, TGM2
32doxycycline45 1111.2PLAU, MMP3, CD79A
33aspirin45 50 29 2413.2PLAU, IL2RB, CD79A, CCL11
34glutamine4510.2TGM2, TGM1, PLAU, MMP3, HLA-DQB1
35serine4510.2EDNRB, FBN1, IL2RB, MMP3, MMP12, TPSB2
36paraffin4510.2TRB, CD79A, MMP3, MMP7, PLAU
37steroid4510.1CCL11, EDNRB, CD79A, IL2RB, PLAU, TGM1
38progesterone45 60 29 11 2414.1FBN1, IL2RB, MMP3, MMP7, PLAU, TGM1
39heparin45 29 11 2413.1CCL11, FBN1, CD79A, MMP3
40arginine4510.0EDNRB, FBN1, CD79A, IL2RB, PLAU, TGM1
41alanine4510.0CCL11, EDNRB, FBN1, CD79A, IL2RB, MMP3
42vegf4510.0CCL11, EDNRB, CD79A, IL2RB, MMP3, MMP12
43phosphatidylinositol4510.0CCL11, EDNRB, IL2RB, MMP12, MMP7, PLAU
44cysteine4510.0EDNRB, FBN1, CD79A, MMP3, MMP7, PLAU
45nitric oxide45 11 2411.9CCL11, EDNRB, IL2RB, MMP12, MMP7, TGM1
46retinoid459.9TGM2, TGM1, PLAU, IL2RB
47retinoic acid45 2410.8TGM2, CCL11, EDNRB, FBN1, CD79A, IL2RB
48ribonucleic acid459.7IL2RB, MMP3, MMP7, PLAU
49tyrosine459.7CCL11, HLA-DQB1, EDNRB, FBN1, TRB, IL2RB
50calcium45 50 11 2412.4IL2RB, TRB, FBN1, EDNRB, CCL11, MMP3

GO Terms for genes affiliated with Dermatitis Herpetiformis

Sources:
16Gene Ontology
See all sources

Cellular components related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.0MMP7, MMP12, MMP3, FBN1
2extracellular regionGO:0055769.1TPSB2, CCL11, FBN1, CGREF1, IGHA1, MMP3

Biological processes related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell envelope organizationGO:04316310.3TGM3, TGM1
2peptide cross-linkingGO:01814910.2TGM3, TGM6, TGM1
3collagen catabolic processGO:03057410.0MMP3, MMP12, MMP7
4extracellular matrix organizationGO:03019810.0MMP7, MMP12, MMP3, FBN1
5proteolysisGO:0065089.9MMP3, MMP12, MMP7, PLAU, TPSB2
6extracellular matrix disassemblyGO:0226179.8MMP7, MMP12, MMP3

Molecular functions related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein-glutamine gamma-glutamyltransferase activityGO:0038109.9TGM3, TGM6, TGM2, TGM1
2calcium ion bindingGO:0055099.8TGM3, MMP12, MMP3, CGREF1, FBN1
3metalloendopeptidase activityGO:0042229.8MMP3, MMP12, MMP7

Products for genes affiliated with Dermatitis Herpetiformis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dermatitis Herpetiformis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet