MCID: DRM007
MIFTS: 64

Dermatitis Herpetiformis malady

Genetic diseases, Skin diseases, Rare diseases, Immune diseases categories

Summaries for Dermatitis Herpetiformis

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Dermatitis herpetiformis (DH), or Duhring\'s disease, is a chronic blistering skin condition,... more...

MalaCards: Dermatitis Herpetiformis, also known as dermatosis herpetiformis, is related to dermatitis and celiac disease, and has symptoms including bone pain, cutaneous edema and erythema/erythematous lesions/erythroderma/polymorphous erythema. An important gene associated with Dermatitis Herpetiformis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Matrix Metalloproteinases and GPCR Pathway. The drugs dapsone and sulfapyridine pwdr and the compounds gluten and unicap have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and t cells, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Description from OMIM:48 601230

Aliases & Classifications for Dermatitis Herpetiformis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 50Orphanet, 48OMIM, 63UMLS, 36MeSH, 41NCIt, 28ICD9CM, 59SNOMED-CT, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Skin diseases, Immune diseases
Orphanet: 50 
Rare skin diseases


Characteristics (Orphanet epidemiological data):

50
dermatitis herpetiformis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

dermatitis herpetiformis 9 11 46 50 48 63
dermatosis herpetiformis 9
durhing-brocq disease 50
duhring's disease 9


External Ids:

Disease Ontology9 DOID:8505
MeSH36 D003874
NCIt41 C26742
ICD9CM28 694.0
OMIM48 601230
MESH via Orphanet37 D003874
ICD10 via Orphanet27 L13.0
SNOMED-CT via Orphanet60 111196000
UMLS via Orphanet64 C0011608
ICD1026 L13.0

Related Diseases for Dermatitis Herpetiformis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Dermatitis Herpetiformis family:

Juvenile Dermatitis Herpetiformis Dermatitis Herpetiformis Familial

Diseases related to Dermatitis Herpetiformis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis32.3CCL11, CD79A
2celiac disease31.3CD79A, MMP12, TGM2
3bullous pemphigoid31.1CCL11, PLAU, CD79A
4ulcerative colitis30.7MMP3, CCL11, CD79A
5pemphigus30.5CD79A, PLAU
6arthritis30.5MMP12, MMP3, IL2RB
7primary biliary cirrhosis30.4CD79A, IL2RB
8epidermolysis bullosa acquisita30.3CD79A
9gastroenteritis30.3CD79A
10systemic lupus erythematosus30.3CD79A, IL2RB, MMP3
11rheumatoid arthritis30.2MMP12, MMP3, CCL11, IL2RB, CD79A
12ankylosing spondylitis30.2CD79A, MMP3
13sarcoidosis30.2IL2RB, CCL11
14lung cancer30.1PLAU, MMP12, TGM2
15juvenile dermatitis herpetiformis10.7
16linear iga disease10.6
17lupus erythematosus10.5
18vitiligo10.5
19thyroiditis10.5
20herpes gestationis10.4
21gastritis10.4
22psoriasis10.4
23dermatitis herpetiformis familial10.4
24discoid lupus erythematosus10.4
25duodenitis10.3
26sclerosing cholangitis10.3
27cholangitis10.3
28epidermolysis bullosa10.3
29urticaria10.3
30primary sclerosing cholangitis10.3
31atrophic gastritis10.3
32protein-losing enteropathy10.3
33subcorneal pustular dermatosis10.3
34impetigo herpetiformis10.3
35anaplastic large cell lymphoma10.3
36stiff-person syndrome10.3
37cutaneous t cell lymphoma10.3
38diabetes mellitus10.3
39glomerulonephritis10.3
40impetigo10.3
41intestinal disease10.3
42laryngitis10.3
43pancreatitis10.3
44purpura10.3
45duhring brocq disease10.3
46ataxia10.3
47endotheliitis10.3
48poems syndrome10.1CD79A
49conjunctivitis10.1CD79A
50exanthem10.1CD79A

Graphical network of the top 20 diseases related to Dermatitis Herpetiformis:



Diseases related to dermatitis herpetiformis

Symptoms for Dermatitis Herpetiformis

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Sources:
48OMIM, 50Orphanet
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Symptoms by clinical synopsis from OMIM:

601230

Clinical features from OMIM:

601230

Symptoms:

50 (show all 15)
  • bone pain
  • cutaneous edema
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • follicular/erythematous/edematous papules/milium
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • negative nikolski's sign
  • pruritus/itching
  • malabsorption/chronic diarrhea/steatorrhea
  • mutiple fractures/bone fragility
  • autoimmunity/autoimmune reaction/autoantibodies
  • microcytic anemia
  • eczema
  • lichen
  • urticaria

Drugs & Therapeutics for Dermatitis Herpetiformis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Dermatitis Herpetiformis

Drug clinical trials:

Search ClinicalTrials for Dermatitis Herpetiformis

Search NIH Clinical Center for Dermatitis Herpetiformis

Search CenterWatch for Dermatitis Herpetiformis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Dermatitis Herpetiformis

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Anatomical Context for Dermatitis Herpetiformis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Dermatitis Herpetiformis:

34
Skin, Bone, T cells, Thyroid, Small intestine, Testes, Endothelial, Pituitary, Heart, Colon, Liver, Lung, Tonsil

Animal Models for Dermatitis Herpetiformis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Dermatitis Herpetiformis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.9CD79A, PLAU, MMP3, MMP12, TGM2
2MP:00036317.6TGM2, MMP12, MMP3, PLAU, CD79A
3MP:00053976.7CD79A, TGM2, MMP12, MMP3, CCL11, IL2RB
4MP:00053876.6TGM2, MMP12, MMP3, CCL11, IL2RB, PLAU

Publications for Dermatitis Herpetiformis

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Sources:
53PubMed
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Articles related to Dermatitis Herpetiformis:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
IL-17 expression in dermatitis herpetiformis and bullous pemphigoid. (23970818)
2013
2
Does dermatitis herpetiformis result in bone loss as coeliac disease does? A cross sectional study. (23859446)
2013
3
Management of dermatitis herpetiformis. (22560140)
2012
4
Long-term combination therapy of ustekinumab and dapsone in a patient with psoriasis and dermatitis herpetiformis Duhring. (22784106)
2012
5
Autoimmunity-driven enzymatic remodeling of the dermal-epidermal junction in bullous pemphigoid and dermatitis herpetiformis. (21916544)
2012
6
The long-term risk of malignancy following a diagnosis of coeliac disease or dermatitis herpetiformis: a cohort study. (22288441)
2012
7
Reduced mortality in dermatitis herpetiformis: a population-based study of 476 patients. (22708883)
2012
8
Does Adam17 cause the destruction of anchoring fibers via shedding tumor necrosis factor I+ in bullous pemphigoid and dermatitis herpetiformis? (22713436)
2012
9
Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. (22560139)
2012
10
Discontinuing dapsone treatment and reintroducing dietary gluten in patients with dermatitis herpetiformis in remission: comment on "remission in dermatitis herpetiformis". (21422338)
2011
11
Acupuncture and a gluten-free diet relieve urticaria and eczema in a case of undiagnosed dermatitis herpetiformis and atypical or extraintestinal celiac disease: a case report. (22654688)
2011
12
The falling incidence and prevalence of dermatitis herpetiformis. (21777210)
2011
13
Inflammatory epidermolysis bullosa acquisita mimicking toxic epidermal necrolysis and dermatitis herpetiformis. (19663858)
2009
14
Might dermatitis herpetiformis be associated with discoid lupus erythematosus? (18482033)
2008
15
Childhood dermatitis herpetiformis: a case report and review of the literature. (18246879)
2007
16
Permeability, zonulin production, and enteropathy in dermatitis herpetiformis. (15822038)
2005
17
Medical pearl: Using tissue transglutaminase antibodies to diagnose dermatitis herpetiformis. (16243141)
2005
18
A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice. (15489956)
2004
19
Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis. (11247893)
2001
20
Concordance of dermatitis herpetiformis and celiac disease in monozygous twins. (11121131)
2000
21
Dermatitis herpetiformis effectively treated with heparin, tetracycline and nicotinamide. (10844495)
2000
22
Tissue transglutaminase antibodies in dermatitis herpetiformis. (10490368)
1999
23
Hemidesmosomal molecular changes in dermatitis herpetiformis; decreased expression of BP230 and plectin/HD1 in uninvolved skin. (10416682)
1999
24
Th2-like cytokine activity in dermatitis herpetiformis. (9602868)
1998
25
Risk factors for ischaemic heart disease in patients with dermatitis herpetiformis. (9204017)
1997
26
Dermatitis herpetiformis following gastric surgery. (9006392)
1997
27
Parallel interleukin 5 synthesis by eosinophils in duodenal and skin lesions of a patient with dermatitis herpetiformis. (7672663)
1995
28
Dermatitis herpetiformis induced by nonsteroidal anti-inflammatory drugs. (8169023)
1994
29
IgA antibodies against reticulin and endomysium in the serum and gastrointestinal secretions of patients with dermatitis herpetiformis. (8049567)
1994
30
Efficacy of cyclosporine in two patients with dermatitis herpetiformis resistant to conventional therapy. (8496445)
1993
31
Increased jejunal intraepithelial lymphocytes bearing gamma/delta T-cell receptor in dermatitis herpetiformis. (1314748)
1992
32
Role of elemental diet in dermatitis herpetiformis. (1935210)
1991
33
Intestinal humoral immunity in dermatitis herpetiformis. (1975360)
1990
34
Laryngeal involvement in dermatitis herpetiformis. (2312825)
1990
35
Manic depression induced by dapsone in patient with dermatitis herpetiformis. (2510873)
1989
36
Normal IgA production by peripheral blood lymphocytes in dermatitis herpetiformis and linear IgA dermatosis. (2919896)
1989
37
Dermatitis herpetiformis. (3153433)
1988
38
Dermatitis herpetiformis: a case with palmar purpuric lesions treated with disodium cromoglycate. (3139724)
1988
39
Aggressive gluten challenge of dermatitis herpetiformis cases converts them from seronegative to seropositive for IgA-class endomysial antibodies. (3372760)
1988
40
Dermatitis herpetiformis and hemodialysis. (3678553)
1987
41
Dermatitis herpetiformis: relation between circulating immune complexes, small-intestinal mucosal status, and immunohistopathological findings. (3632036)
1987
42
IgA endomysium antibody in children with dermatitis herpetiformis treated with gluten-free diet. (3774647)
1986
43
Anti-endomysial antibodies. A serologic marker of dermatitis herpetiformis. (3513713)
1986
44
The relationship between dapsone dose, serum concentration and disease severity in dermatitis herpetiformis. (3954818)
1986
45
Characterization of circulating and cutaneous IgA immune complexes in patients with dermatitis herpetiformis. (4020133)
1985
46
Thyroid abnormalities in dermatitis herpetiformis. Prevalence of clinical thyroid disease and thyroid autoantibodies. (3966757)
1985
47
Intestinal permeability in patients with coeliac disease and dermatitis herpetiformis. (3934051)
1985
48
Atypical dermatitis herpetiformis in two patients with internal malignancy. (6744651)
1984
49
Adult coeliac disease. A case with ulceration, dermatitis herpetiformis and reticulosarcoma. (766153)
1976
50
Juvenile dermatitis herpetiformis (a case report). (4777767)
1973

Variations for Dermatitis Herpetiformis

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Expression for genes affiliated with Dermatitis Herpetiformis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dermatitis Herpetiformis

Search GEO for disease gene expression data for Dermatitis Herpetiformis.

Pathways for genes affiliated with Dermatitis Herpetiformis

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 61Thomson Reuters, 13EMD Millipore, 31KEGG
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Compounds for genes affiliated with Dermatitis Herpetiformis

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 3BitterDB, 30IUPHAR, 25HMDB
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Compounds related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1gluten4610.0CD79A, TGM2
2unicap4610.0CCL11, CD79A
3reticulin469.9TGM2, CD79A
4sodium cromoglycate469.9CD79A, CCL11
5gliadin469.9TGM2, CD79A
6n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid46 1210.6MMP3, MMP12
7clarithromycin46 1210.6CCL11, CD79A
8piroxicam46 1210.5CD79A, MMP3
9nimesulide46 1210.5PLAU, MMP3
10uk 383367629.4MMP12, MMP3
11methacholine46 52 1211.4CD79A, IL2RB, CCL11
12gi 254023x629.4MMP12, MMP3
13azathioprine46 3 52 1212.3CD79A, PLAU, IL2RB
14gm 6001629.3MMP12, MMP3
15mnng469.3PLAU, MMP3
16tacrolimus46 52 1211.3CCL11, IL2RB, CD79A
17doxycycline46 1210.2MMP3, PLAU, CD79A
18marimastat46 62 1211.2PLAU, MMP3, MMP12
19batimastat46 62 1211.1MMP12, MMP3, PLAU
20fibrinogen469.1TGM2, MMP12, PLAU, CD79A
21retinoid469.1PLAU, IL2RB, TGM2
22etanercept46 52 1211.0MMP12, MMP3, IL2RB
23adalimumab46 52 1211.0CD79A, MMP3
24methotrexate52 46 1210.9CD79A, IL2RB, MMP3
25aspirin46 52 30 2511.9CCL11, IL2RB, PLAU, CD79A
26steroid468.8CCL11, IL2RB, PLAU, CD79A
27rantes468.7MMP3, CCL11, IL2RB
28phosphatidylinositol468.7PLAU, IL2RB, CCL11, MMP12
29hyaluronic acid46 259.7MMP3, CCL11, PLAU, CD79A
30indomethacin46 30 62 1211.7CD79A, PLAU, CCL11, MMP3
31matrigel468.6PLAU, CCL11, MMP3, MMP12
32heparin46 30 25 1211.6MMP3, CCL11, PLAU, CD79A
33prednisolone46 30 1210.6CD79A, IL2RB, CCL11, MMP3
34glutamate468.6TGM2, MMP3, PLAU, CD79A
35cyclosporin a46 30 6210.5MMP3, CCL11, IL2RB, CD79A
36lactate468.5CD79A, PLAU, IL2RB, MMP3
3712-o-tetradecanoylphorbol 13-acetate468.5PLAU, IL2RB, MMP3
38creatinine468.5MMP3, IL2RB, PLAU, CD79A
39ribonucleic acid468.4MMP3, IL2RB, PLAU
40dexamethasone46 52 30 1211.2MMP12, MMP3, CCL11, IL2RB, CD79A
41histamine46 30 2510.1MMP3, CCL11, IL2RB, PLAU, CD79A
42pge2468.1MMP3, CCL11, IL2RB, PLAU, CD79A
43oxygen46 259.0TGM2, MMP12, MMP3, CCL11, IL2RB
44genistein46 30 62 3 25 1213.0MMP12, MMP3, CCL11, IL2RB, PLAU
45serine468.0TGM2, MMP12, MMP3, IL2RB, PLAU
46tyrosine467.9MMP12, MMP3, CCL11, IL2RB, PLAU
47n acetylcysteine467.7CD79A, PLAU, IL2RB, CCL11, MMP3, MMP12
48vegf467.7MMP12, MMP3, CCL11, IL2RB, PLAU, CD79A
49alanine467.6TGM2, MMP3, CCL11, IL2RB, PLAU, CD79A
50retinoic acid46 258.6TGM2, MMP3, CCL11, IL2RB, PLAU, CD79A

GO Terms for genes affiliated with Dermatitis Herpetiformis

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17Gene Ontology
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Cellular components related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2PLAU, CCL11, MMP3, MMP12

Biological processes related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226179.2MMP3, MMP12
2collagen catabolic processGO:0305748.9MMP3, MMP12
3proteolysisGO:0065088.6PLAU, MMP3, MMP12

Molecular functions related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.2MMP3, MMP12

Products for genes affiliated with Dermatitis Herpetiformis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dermatitis Herpetiformis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet