MCID: DRM007
MIFTS: 66

Dermatitis Herpetiformis malady

Skin diseases category

Summaries for Dermatitis Herpetiformis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Dermatitis herpetiformis (DH), or Duhring\'s disease, is a chronic blistering skin condition,... more...

MalaCards: Dermatitis Herpetiformis, also known as dermatosis herpetiformis, is related to dermatitis and celiac disease, and has symptoms including lichen, negative nikolski's sign and erythema/erythematous lesions/erythroderma/polymorphous erythema. An important gene associated with Dermatitis Herpetiformis is CD79A (CD79a molecule, immunoglobulin-associated alpha), and among its related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix. The drugs dapsone and sulfapyridine pwdr and the compounds glutamate and gliadin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and t cells, and related mouse phenotypes are respiratory system and renal/urinary system.

Description from OMIM:46 601230

Aliases & Classifications for Dermatitis Herpetiformis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
dermatitis herpetiformis:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

dermatitis herpetiformis 8 10 44 48 46 60
dermatosis herpetiformis 8
durhing-brocq disease 48
duhring's disease 8


External Ids:

Disease Ontology8 DOID:8505
ICD9CM27 694.0
NCIt39 C26742
MeSH34 D003874
OMIM46 601230
MESH via Orphanet35 D003874
ICD10 via Orphanet26 L13.0
SNOMED-CT via Orphanet57 111196000
UMLS via Orphanet61 C0011608
ICD1025 L13.0

Related Diseases for Dermatitis Herpetiformis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Dermatitis Herpetiformis family:

Juvenile Dermatitis Herpetiformis Dermatitis Herpetiformis Familial

Diseases related to Dermatitis Herpetiformis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis32.1CD79A, CCL11
2celiac disease31.2HLA-DQB1, TRB, MMP12, TGM2, CD79A
3bullous pemphigoid31.0CCL11, CD79A, PLAU, HLA-DQB1
4ulcerative colitis30.6MMP7, MMP3, CCL11, CD79A
5psoriasis30.5TGM3, TRB, TGM1, CCL11
6skin disease30.5TGM3, CCL11, TRB, CD79A, TGM1
7arthritis30.4FBN1, MMP3, TRB, MMP12, IL2RB
8purpura30.3CD79A
9pemphigus30.3PLAU, CD79A
10diabetes mellitus30.3MMP3, CD79A, HLA-DQB1
11systemic lupus erythematosus30.3IL2RB, CD79A, TRB, MMP3, FBN1, HLA-DQB1
12rheumatoid arthritis30.3MMP12, TRB, CD79A, IL2RB, MMP3, HLA-DQB1
13myasthenia gravis30.1HLA-DQB1
14stevens-johnson syndrome30.1TGM1
15ankylosing spondylitis30.1CD79A
16hepatitis c30.1MMP7
17hepatitis30.1CCL11, IL2RB
18sarcoidosis30.1IL2RB, CCL11, TRB, HLA-DQB1
19gastroenteritis30.1CD79A
20leukemia30.1CD79A, CCL11, TRB, IL2RB
21lung cancer30.1TRB, PLAU, MMP7, MMP3
22juvenile dermatitis herpetiformis10.7
23lupus erythematosus10.5
24vitiligo10.4
25thyroiditis10.4
26herpes gestationis10.4
27gastritis10.4
28intestinal disease10.4
29dermatitis herpetiformis familial10.4
30duodenitis10.3
31sclerosing cholangitis10.3
32cholangitis10.3
33epidermolysis bullosa10.3
34urticaria10.3
35impetigo herpetiformis10.2
36subcorneal pustular dermatosis10.2
37atrophic gastritis10.2
38primary biliary cirrhosis10.2
39protein-losing enteropathy10.2
40stiff-person syndrome10.2
41anaplastic large cell lymphoma10.2
42cutaneous t cell lymphoma10.2
43glomerulonephritis10.2
44impetigo10.2
45laryngitis10.2
46pancreatitis10.2
47duhring brocq disease10.2
48deficiency anemia10.1
49membranous glomerulonephritis10.1
50relapsing polychondritis10.1

Graphical network of the top 20 diseases related to Dermatitis Herpetiformis:



Diseases related to dermatitis herpetiformis

Clinical Features for Dermatitis Herpetiformis

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

601230

Clinical synopsis from OMIM:

601230

Symptoms:

48 (show all 15)
  • lichen
  • negative nikolski's sign
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • follicular/erythematous/edematous papules/milium
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • pruritus/itching
  • cutaneous edema
  • mutiple fractures/bone fragility
  • autoimmunity/autoimmune reaction/autoantibodies
  • urticaria
  • microcytic anemia
  • bone pain
  • eczema
  • malabsorption/chronic diarrhea/steatorrhea

Drugs & Therapeutics for Dermatitis Herpetiformis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dermatitis Herpetiformis

Drug clinical trials:

Search ClinicalTrials for Dermatitis Herpetiformis

Search NIH Clinical Center for Dermatitis Herpetiformis

Search CenterWatch for Dermatitis Herpetiformis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Dermatitis Herpetiformis

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Anatomical Context for Dermatitis Herpetiformis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Dermatitis Herpetiformis:

32
Skin, Bone, T cells, Small intestine, Thyroid, Testes, Endothelial, Tonsil, Liver, Lung, Heart, Pituitary, Colon

Animal Models for Dermatitis Herpetiformis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Dermatitis Herpetiformis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.8CCL11, HLA-DQB1, EDNRB, FBN1, TRB, MMP12
2MP:00053679.7EDNRB, FBN1, TRB, CD79A, TGM2, HLA-DQB1
3MP:00107719.7EDNRB, FBN1, TRB, MMP12, TGM1
4MP:00053859.5HLA-DQB1, EDNRB, FBN1, TRB, MMP12, MMP7
5MP:00053769.4CD79A, FBN1, EDNRB, HLA-DQB1, MMP3, MMP12
6MP:00053849.4HLA-DQB1, EDNRB, FBN1, TRB, CD79A, IL2RB
7MP:00053979.3CCL11, HLA-DQB1, FBN1, TRB, TRAT1, CD79A
8MP:00036319.1HLA-DQB1, EDNRB, FBN1, TRB, CD79A, MMP3
9MP:00053879.0TGM2, CCL11, HLA-DQB1, EDNRB, FBN1, TRB

Publications for Dermatitis Herpetiformis

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Sources:
50PubMed
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Articles related to Dermatitis Herpetiformis:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Dermatitis herpetiformis. (23674144)
2013
2
Flow cytometric analyses of circulating regulatory T cells in patients with dermatitis herpetiformis and other immune mediated dermatoses. (23588145)
2013
3
Distinct characteristics in Japanese dermatitis herpetiformis: a review of all 91 Japanese patients over the last 35 years. (22778765)
2012
4
Novel assay for detecting celiac disease-associated autoantibodies in dermatitis herpetiformis using deamidated gliadin-analogous fusion peptides. (21840083)
2012
5
Newly described clinical and immunopathological feature of dermatitis herpetiformis. (22701503)
2012
6
Dermatitis herpetiformis, primary hypothyroidism and pituitary mass mimicking macroadenoma regression after treatment with thyroxin, corticosteroids and dapsone. (22345786)
2011
7
Detection of antibodies to epidermal transglutaminase but not tissue transglutaminase in Japanese patients with dermatitis herpetiformis. (21114479)
2011
8
Comment on "Dermatitis herpetiformis sera or goat anti-transglutaminase-3 transferred to human skin-grafted mice mimics dermatitis herpetiformis immunopathology". (21734078)
2011
9
Clinical, histological and immunpathological findings in 32 patients with dermatitis herpetiformis Duhring. (19878401)
2010
10
Expression of selected ADAMs in bullous pemphigoid and dermatitis herpetiformis. (19695840)
2009
11
Dermatitis herpetiformis in siblings. (18309643)
2007
12
The imbalance between metalloproteinases and their tissue inhibitors is involved in the pathogenesis of dermatitis herpetiformis. (16489258)
2005
13
A Japanese case of dermatitis herpetiformis with facial and palmar lesions. (15807697)
2005
14
Leuprolide acetate-induced dermatitis herpetiformis. (15732435)
2005
15
Dermatitis herpetiformis. (14594581)
2003
16
Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. (12404215)
2002
17
Dermatitis herpetiformis in Japan: an update. (11834848)
2002
18
TCR Vbeta expression in the small bowel of patients with dermatitis herpetiformis and gluten sensitive enteropathy. Limited expression in dermatitis herpetiformis and treated asymptomatic gluten sensitive enteropathy. (10949550)
2000
19
Childhood dermatitis herpetiformis: an unusual presentation. (10457132)
1999
20
Absence of toxicity of oats in patients with dermatitis herpetiformis. (9583980)
1998
21
Lack of proliferative response by gluten-specific T cells in the blood and gut of patients with dermatitis herpetiformis. (7492350)
1995
22
Can chemicals precipitate dermatitis herpetiformis? (8425950)
1993
23
Dietary treatment of dermatitis herpetiformis. (1600929)
1992
24
Dermatitis herpetiformis: histopathologic findings. (1806216)
1991
25
Laryngeal involvement in dermatitis herpetiformis. (2312825)
1990
26
Dermatitis herpetiformis bodies. Ultrastructural study on the skin of patients using direct preembedding immunogold labeling. (2241200)
1990
27
Dermatitis herpetiformis and gluten sensitive enteropathy (including celiac disease)--increased subepithelial extracellular matrix viscosity due to gliadin. (2090932)
1990
28
Dermatitis herpetiformis--what is it? (2196234)
1990
29
IgA immunoreactive deposits collocal with fibrillin immunoreactive fibers in dermatitis herpetiformis skin. (1972829)
1990
30
Dermatitis herpetiformis. (2488870)
1989
31
Dermatitis herpetiformis: a case with palmar purpuric lesions treated with disodium cromoglycate. (3139724)
1988
32
Aggressive gluten challenge of dermatitis herpetiformis cases converts them from seronegative to seropositive for IgA-class endomysial antibodies. (3372760)
1988
33
Nutritional status in patients with dermatitis herpetiformis. (3407614)
1988
34
Dermatitis herpetiformis: relation between circulating immune complexes, small-intestinal mucosal status, and immunohistopathological findings. (3632036)
1987
35
Dietary management of dermatitis herpetiformis. (3662571)
1987
36
Prevalence of duodenal and jejunal lesions in dermatitis herpetiformis. (3671997)
1987
37
HLA antigens, jejunal morphology and associated diseases in children with dermatitis herpetiformis. (3962661)
1986
38
Proteolytic enzymes in blister fluids from patients with dermatitis herpetiformis. (3006737)
1986
39
Dermatitis herpetiformis exacerbated by indomethacin. (3994920)
1985
40
IgA class reticulin antibodies in dermatitis herpetiformis: a good indicator of jejunal damage. (2413688)
1985
41
Gastric morphology and function in dermatitis herpetiformis and in coeliac disease. (3992169)
1985
42
Atypical dermatitis herpetiformis in two patients with internal malignancy. (6744651)
1984
43
Dermatitis herpetiformis, lymphoma, and gluten-free diet. (6725667)
1984
44
Is dermatitis herpetiformis a nutritional disease with hematologic consequences? (6746181)
1984
45
Dermatitis herpetiformis: preparation of papillary dermis and the effect of proteolytic enzymes on the IgA deposits. (6392432)
1984
46
Demonstration of tissue 90 kD glycoprotein as antigen in circulating IgG immune complexes in dermatitis herpetiformis and coeliac disease. (6148620)
1984
47
Juvenile dermatitis herpetiformis (a case report). (4777767)
1973
48
Dermatitis herpetiformis; prurigo nodularis; fixed drug eruption (phenolphthalein). (14884719)
1952
49
Dermatitis herpetiformis, Duhring, herpes gestationis. (18888589)
1948
50
A case for diagnosis (papular urticaria? dermatitis herpetiformis?). (20240704)
1947

Genetic Variations for Dermatitis Herpetiformis

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Expression for genes affiliated with Dermatitis Herpetiformis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dermatitis Herpetiformis

Search GEO for disease gene expression data for Dermatitis Herpetiformis.

Pathways for genes affiliated with Dermatitis Herpetiformis

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Dermatitis Herpetiformis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1glutamate4410.8FBN1
2gliadin4410.7TGM2, CD79A
3pge24410.7PLAU, CCL11
4indomethacin44 59 28 1113.6PLAU, EDNRB
5tgm 24410.6TGM3, TGM2
6n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid44 1111.6MMP12, MMP3
7uk 3833675910.5MMP3, MMP12, MMP7
8gi 254023x5910.5MMP3, MMP12, MMP7
9gm 60015910.5MMP3, MMP12, MMP7
10unicap4410.5CD79A, CCL11
11etanercept44 49 1112.5MMP12, MMP3, IL2RB
12marimastat44 59 1112.5MMP3, MMP12, MMP7, PLAU
13batimastat44 59 1112.5MMP3, MMP12, MMP7, PLAU
14prednisolone44 28 1112.4CCL11, CD79A, IL2RB, MMP3
15methacholine44 1111.4IL2RB, CD79A, CCL11
16azathioprine44 49 2 1113.4EDNRB, CD79A, IL2RB, PLAU
17l-glutamine28 11 2412.4TGM1, TGM2, TGM6, TGM3
18sodium dodecylsulfate4410.4FBN1, CD79A, PLAU, TGM1
19hyaluronic acid44 2411.4CCL11, FBN1, CD79A, MMP3, PLAU
20epsilon-(gamma-glutamyl)lysine4410.4TGM1, TGM2
21dexamethasone44 49 28 1113.3CCL11, EDNRB, CD79A, MMP12
22matrigel4410.3CCL11, MMP3, MMP12, MMP7, PLAU
23phorbol4410.3TRB, MMP3, PLAU, TGM1
24histamine44 28 2412.3CCL11, CD79A, IL2RB, MMP3, PLAU
25n acetylcysteine4410.3CCL11, CD79A, IL2RB, MMP3, MMP12, PLAU
26fibrinogen4410.3CD79A, MMP12, MMP7, PLAU, TGM2
27cyclosporin a44 28 5912.3CCL11, EDNRB, TRB, CD79A, IL2RB
28gluten4410.3TGM2, CD79A
29genistein44 28 59 2 11 2415.3CCL11, IL2RB, MMP3, MMP12, PLAU
30dmso4410.2EDNRB, MMP3, MMP7, PLAU
31oxygen44 2411.2CCL11, EDNRB, FBN1, IL2RB, MMP12, TGM2
32doxycycline44 1111.2PLAU, MMP3, CD79A
33aspirin44 49 28 2413.2PLAU, IL2RB, CD79A, CCL11
34glutamine4410.2TGM2, TGM1, PLAU, MMP3, HLA-DQB1
35serine4410.2EDNRB, FBN1, IL2RB, MMP3, MMP12, TPSB2
36paraffin4410.2TRB, CD79A, MMP3, MMP7, PLAU
37steroid4410.1CCL11, EDNRB, CD79A, IL2RB, PLAU, TGM1
38progesterone44 59 28 11 2414.1FBN1, IL2RB, MMP3, MMP7, PLAU, TGM1
39heparin44 28 11 2413.1CCL11, FBN1, CD79A, MMP3
40arginine4410.0EDNRB, FBN1, CD79A, IL2RB, PLAU, TGM1
41alanine4410.0CCL11, EDNRB, FBN1, CD79A, IL2RB, MMP3
42vegf4410.0CCL11, EDNRB, CD79A, IL2RB, MMP3, MMP12
43phosphatidylinositol4410.0CCL11, EDNRB, IL2RB, MMP12, MMP7, PLAU
44cysteine4410.0EDNRB, FBN1, CD79A, MMP3, MMP7, PLAU
45nitric oxide44 11 2411.9CCL11, EDNRB, IL2RB, MMP12, MMP7, TGM1
46retinoid449.9TGM2, TGM1, PLAU, IL2RB
47retinoic acid44 2410.8TGM2, CCL11, EDNRB, FBN1, CD79A, IL2RB
48ribonucleic acid449.7IL2RB, MMP3, MMP7, PLAU
49tyrosine449.7CCL11, HLA-DQB1, EDNRB, FBN1, TRB, IL2RB
50calcium44 49 11 2412.4IL2RB, TRB, FBN1, EDNRB, CCL11, MMP3

GO Terms for genes affiliated with Dermatitis Herpetiformis

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Sources:
16Gene Ontology
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Cellular components related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00557810.0MMP7, MMP12, MMP3, FBN1
2extracellular regionGO:0055769.1TPSB2, CCL11, FBN1, CGREF1, IGHA1, MMP3

Biological processes related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell envelope organizationGO:04316310.3TGM3, TGM1
2peptide cross-linkingGO:01814910.2TGM3, TGM6, TGM1
3collagen catabolic processGO:03057410.0MMP3, MMP12, MMP7
4extracellular matrix organizationGO:03019810.0MMP7, MMP12, MMP3, FBN1
5proteolysisGO:0065089.9MMP3, MMP12, MMP7, PLAU, TPSB2
6extracellular matrix disassemblyGO:0226179.8MMP7, MMP12, MMP3

Molecular functions related to Dermatitis Herpetiformis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein-glutamine gamma-glutamyltransferase activityGO:0038109.9TGM3, TGM6, TGM2, TGM1
2calcium ion bindingGO:0055099.8TGM3, MMP12, MMP3, CGREF1, FBN1
3metalloendopeptidase activityGO:0042229.8MMP3, MMP12, MMP7

Products for genes affiliated with Dermatitis Herpetiformis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dermatitis Herpetiformis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet