Dermatitis Herpetiformis malady

Wikipedia: Dermatitis herpetiformis (DH), or Duhring\'s disease, is a chronic blistering skin condition,...⁴⁴ more...

MalaCards: Dermatitis Herpetiformis, also known as dermatitis herpetiformis (disorder), is related to celiac disease and psoriatic arthritis. An important gene associated with Dermatitis Herpetiformis is TGM3 (transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)), and among its related pathways are Immune response_NFAT in immune response and Cell adhesion molecules (CAMs). The drugs dapsone and sulfapyridine and the compounds ivig and budesonide have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and t cells, and related mouse phenotypes are respiratory system and liver/biliary system.

Aliases & Descriptions:

dermatitis herpetiformis 6 8 32 43 dermatitis herpetiformis (disorder) 6 dermatitis herpetiformis (disorder) 6

dermatosis herpetiformis 6 duhring's disease 6

Diseases related to dermatitis herpetiformis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 496)

id	Related Disease	Score	Top Affiliating Genes
1	celiac disease	31.9	HLA-DQA1, HLA-DQB1
2	psoriatic arthritis	28.8	SELE, MMP3, IL13, TRB@, TNF
3	bullous pemphigoid	28.5	CD79A, IL13, IL5, CCL11, HLA-DQB1, PLAU
4	duodenitis	28.4	CD79A, CD40LG, MMP12, MMP3, MMP7, IL2RB
5	ataxia	28.2	CD79A, MMP3, FBN1, TNF, DST, TGM2
6	dermatitis	25.5	SELE, MYO9B, CD79A, CD40LG, ITGAM, MMP12
7	psoriasis	22.1	SELE, CD79A, CD40LG, MMP12, MMP3, IL13
8	arthritis	21.1	SELE, CD79A, CD40LG, ITGAM, MMP12, MMP3
9	pemphigoid gestationis	13.5	CCL11, DST
10	tubulointerstitial nephritis and uveitis	13.5	HLA-DQA1, HLA-DQB1
11	cryofibrinogenemia	13.5	CD79A, CD40LG
12	abdominal aortic aneurysm	13.5	MMP12, MMP3, FBN1, PLAU
13	refractive error	13.4	MMP12, MMP3, MMP7
14	immunoglobulin alpha deficiency	13.4	CD79A, CD40LG, HLA-DQB1
15	posterior uveitis	13.4	IL2RA, IL2RB
16	subcorneal pustular dermatosis	13.4	CD79A, DSG3
17	lipoid nephrosis	13.4	CD79A, IL13, IL2RB
18	chronic eosinophilic pneumonia	13.4	IL5, CCL11
19	pelvic inflammatory disease	13.3	HLA-DQA1, HLA-DQB1, PLAU
20	pediatric ulcerative colitis	13.3	CCL11, TNF
21	strongyloidiasis	13.3	CD79A, IL5, CCL11
22	giant papillary conjunctivitis	13.3	IL5, CCL11
23	impetigo	13.3	CD79A, CD40LG, DSG3
24	cd40 ligand deficiency	13.3	CD79A, CD40LG
25	diffuse infiltrative lymphocytosis syndrome	13.3	IL2RA, IL2RB, TRB@
26	status asthmaticus	13.3	MMP3, IL5, CCL11
27	congenital toxoplasmosis	13.3	CD79A, CD40LG
28	cutis laxa	13.3	CD79A, CD40LG, FBN1
29	peripheral t-cell lymphoma	13.2	IL2RA, IL2RB, TRB@
30	trachoma	13.2	CD79A, HLA-DQB1, TNF
31	neurocirculatory asthenia	13.2	MMP3, FBN1, PLAU
32	bullous skin disease	13.1	IL5, DSG3, DST
33	intestinal schistosomiasis	13.1	IL13, IL5
34	autoimmune thrombocytopenic purpura	13.1	CD79A, CD40LG, IL2RA
35	addison's disease	13.1	CD79A, HLA-DQA1, HLA-DQB1, GAST
36	cardiac tamponade	13.1	CD79A, CD40LG, IL5
37	paraneoplastic syndromes	13.1	CD79A, IL5, TRB@
38	eosinophilic fasciitis	13.1	IL5, TRB@
39	allergic conjunctivitis	13.1	IL13, IL5, CCL11
40	eosinophilic pneumonia	13.1	IL13, IL5, CCL11
41	helminthiasis	13.1	IL13, IL5
42	kimura disease	13.1	IL13, IL5, CCL11
43	gamma chain deficiency	13.1	IL13, IL2RA, IL2RB
44	chronic sphenoidal sinusitis	13.1	IL13, IL5, CCL11
45	food allergy	13.0	IL13, IL5, CCL11
46	acute disseminated encephalomyelitis	13.0	HLA-DQA1, HLA-DQB1, TNF
47	pulmonary eosinophilia	13.0	IL13, IL5, CCL11
48	oral submucous fibrosis	13.0	MMP3, HLA-DQB1, TNF
49	autoimmune hepatitis	13.0	CD40LG, HLA-DQB1, TRB@
50	asthma	13.0	IL13, CCL11, TNF

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dapsone, sulfapyridine

MalaCards organs/tissues related to dermatitis herpetiformis:

²²

MGI Mouse Phenotypes related to dermatitis herpetiformis:

²⁵ (show all 14)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.1	FBN1, GAD1
2	liver/biliary system phenotype	MP:0005370	9.7	APOB, TRB@
3	endocrine/exocrine gland phenotype	MP:0005379	9.7	CD40LG, IL2RB
4	nervous system phenotype	MP:0003631	9.3	GAD1, PLAU, TRB@, HLA-DQB1, FBN1, MMP12
5	digestive/alimentary phenotype	MP:0005381	9.1	GAST, GAD1, DST, DSG3, PLAU, TRB@
6	integument phenotype	MP:0010771	9.0	TGM3, TGM1, DST, DSG3, TRB@, FBN1
7	reproductive system phenotype	MP:0005389	8.8	DST, TNF, FBN1, IL2RB, IL13, MMP12
8	hematopoietic system phenotype	MP:0005397	8.2	TGM2, DST, DSG3, TRB@, TRAT1, HLA-DQB1
9	tumorigenesis	MP:0002006	7.6	GAST, TGM2, PLAU, TNF, TRB@, ICAM1
10	immune system phenotype	MP:0005387	7.4	MYO9B, GAST, TGM2, DSG3, TNF, TRB@
11	mortality/aging	MP:0010768	6.9	DSG3, DST, TGM1, TGM2, GAD1, GAST
12	growth/size phenotype	MP:0005378	6.3	TRB@, PLAU, DSG3, DST, TGM1, GAD1
13	cellular phenotype	MP:0005384	5.5	ICAM1, HLA-DQB1, TRB@, TNF, PLAU, DSG3
14	homeostasis/metabolism phenotype	MP:0005376	4.5	ICAM1, HLA-DQB1, TNF, PLAU, DST, TGM1

Articles related to dermatitis herpetiformis:

(show all 40)

id	Title	Authors	Year	Affiliating Genes
1	Dermatitis herpetiformis sera or goat anti-transgluta minase-3 transferred to human skin-grafted mice mimics dermatitis herpetiformis immunopathology. (21335491)	Zone J.J.... Meyer L.J.	2011	TGM3
2	Clinical, histological and immunpathological findings in 32 patients with dermatitis herpetiformis Duhring. (19878401)	Rose C.... Zillikens D.	2010	CD79A
3	Gluten T cell epitope targeting by TG3 and TG6; impli cations for dermatitis herpetiformis and gluten ataxia. (20300788)	Stamnaes J.... Sollid L.M.	2010	TGM3, TGM6
4	A case of stiff-person syndrome, type 1 diabetes, celiac disease and dermatitis herpetiformis. (19150172)	O'Sullivan E.P.... Smith D.	2009	GAD1
5	Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprue. (17762854)	Marietta E.V.... Murray J.A.	2008	TGM2, TGM1, TGM3
6	Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association. (18077767)	Koskinen L.L.... Saavalainen P.	2008	MYO9B
7	Elevation of IgA anti-epidermal transglutaminase antibodies in dermatitis herpetiformis. (18503599)	Hull C.M.... Zone J.J.	2008	TGM2, CD79A
8	Increased frequency of Ig heavy-chain HS1,2-A enhancer *2 allele in dermatitis herpetiformis, plaque psoriasis, and psoriatic arthritis. (18323783)	Cianci R.... Frezza D.	2008	IGHA1
9	Childhood dermatitis herpetiformis: a case report and review of the literature. (18246879)	Templet J.T.... Cusack C.A.	2007	CD79A
10	Epidermal transglutaminase deposits in perilesional and uninvolved skin in patients with dermatitis herpetiformis. (17205060)	Donaldson M.R.... Meyer L.J.	2007	TGM3
11	Cutaneous endothelial cell activation in normal skin of patients with dermatitis herpetiformis associated with increased serum levels of IL-8, sE-Selectin, and TNF-alpha. (16575390)	Hall R.P.... Streilein R.D.	2006	ICAM1, SELE
12	Dermatitis herpetiformis and partial IgA deficiency. (16631941)	Samolitis N.J.... Zone J.J.	2006	CD79A
13	Erythema elevatum diutinum arising in the setting of dermatitis herpetiformis. (16983903)	Aftab M.N.... Helm T.N.	2006	CD79A
14	Immunoglobulin, complement and epidermal transglutaminase deposition in the cutaneous vessels in dermatitis herpetiformis. (15649195)	Preisz K.... Karpati S.	2005	TGM3
15	Dermatitis herpetiformis (14714018)	Gjersvik P.J.... nnevig J.R.	2003	TGM2
16	Genetic dissection between coeliac disease and dermatitis herpetiformis in sib pairs. (12485471)	Karell K.... Partanen J.	2002	HLA-DQA1
17	Neutrophil CD11b, L-selectin and Fc IgA receptors in patients with dermatitis herpetiformis. (12452859)	Smith A.D.... Hall R.P.	2002	ITGAM
18	Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. (11901200)	Sardy M.... Smyth N.	2002	TGM3
19	Dermatitis herpetiformis: should direct immunofluorescence be the only diagnostic criterion? (12220281)	Sousa L.... Fiadeiro T.	2002	CD79A
20	Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis. (11247893)	Salmela M.T.... Saarialho-Kere U.	2001	MMP7, MMP12
21	Antibodies against tissue transglutaminase as a serological marker in dermatitis herpetiformis During (10907151)	Rose C.... Zillikens D.	2000	CD79A
22	Expression of eotaxin, interleukin 13 and tumour necrosis factor-alpha in dermatitis herpetiformis. (11069505)	Amerio P.... Bossi G.	2000	CCL11, IL13
23	Risk factors for ischaemic heart disease in patients with dermatitis herpetiformis. (9204017)	Lear J.T.... English J.S.	1997	APOB
24	Urokinase plasminogen activator is expressed by basal keratinocytes before interstitial collagenase, stromelysin-1, and laminin-5 in experimentally induced dermatitis herpetiformis lesions. (8980278)	Airola K.... Saarialho-Kere U.K.	1997	MMP3, PLAU
25	Dermatitis herpetiformis occuring in patients with celiac disease in childhood (8881298)	DAcmoulins-Giacco N.... De Prost Y.	1996	CD79A
26	Parallel interleukin 5 synthesis by eosinophils in duodenal and skin lesions of a patient with dermatitis herpetiformis. (7672663)	Desreumaux P.... Colombel J.F.	1995	IL5
27	Comparative genetic association of human leukocyte antigen class II and tumor necrosis factor-alpha with dermatitis herpetiformis. (7738367)	Wilson A.G.... Duff G.W.	1995	TNF
28	Lack of proliferative response by gluten-specific T cells in the blood and gut of patients with dermatitis herpetiformis. (7492350)	Baker B.S.... Fry L.	1995	IL2RA
29	Diagnosis of dermatitis herpetiformis by an avidin-biotin-peroxidase method. (7741544)	Zaenglein A.L.... Helm K.F.	1995	CD79A
30	Enhanced expression of interstitial collagenase, stromelysin-1, and urokinase plasminogen activator in lesions of dermatitis herpetiformis. (7636299)	Airola K.... Saarialho-Kere U.K.	1995	MMP3, PLAU
31	T lymphocytes bearing the gamma/delta T-cell receptor in cutaneous lesions of dermatitis herpetiformis. (7868753)	Kell D.L.... Smoller B.R.	1994	IL2RB
32	Confocal laser scanning microscopic and immunoelectron microscopic studies of the anatomical distribution of fibrillar IgA deposits in dermatitis herpetiformis. (8466215)	Kawana S.... Segawa A.	1993	CD79A
33	Dermatitis herpetiformis--an autoimmune disease due to cross-reaction between dietary glutenin and dermal elastin? (8256113)	BAPdvarsson S.... Valdimarsson H.	1993	CD79A
34	The site of blister formation in dermatitis herpetiformis is within the lamina lucida. (1430358)	Smith J.B.... Zone J.J.	1992	DST
35	Increased jejunal intraepithelial lymphocytes bearing gamma/delta T-cell receptor in dermatitis herpetiformis. (1314748)	Vecchi M.... de Franchis R.	1992	TRAT1
36	Soluble interleukin-2 receptor levels in patients with dermatitis herpetiformis. (1875055)	Ward M.M.... Hall R.P.	1991	IL2RA, CD79A
37	Molecular analysis of HLA DP and DQ genes associated with dermatitis herpetiformis. (1919044)	Fronek Z.... Kagnoff M.F.	1991	HLA-DQB1
38	Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease. (1972433)	O'Mahony S.... Ferguson A.	1990	CD40LG, CD79A
39	IgA immunoreactive deposits collocal with fibrillin immunoreactive fibers in dermatitis herpetiformis skin. (1972829)	Dahlback K.... Sakai L.	1990	FBN1, CD79A
40	Gastric histology and function tests in Italian patients with dermatitis herpetiformis. (2336546)	Primignani M.... de Franchis R.	1990	GAST

Genes related to dermatitis herpetiformis according to GeneCards:

(show all 32)

id	Symbol	Description	Score	GeneCards Section Context
1	TGM3	transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
2	TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
3	MMP12	matrix metallopeptidase 12 (macrophage elastase)	11.0	Publications
4	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
5	IL2RB	interleukin 2 receptor, beta	11.0	Publications
6	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
7	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
8	FBN1	fibrillin 1	11.0	Publications
9	TRB@	T cell receptor beta locus	11.0
10	PLAU	plasminogen activator, urokinase	11.0	Publications
11	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
12	IGKV1-9	immunoglobulin kappa variable 1-9	11.0
13	IGHA1	immunoglobulin heavy constant alpha 1	11.0	Publications
14	TRAT1	T cell receptor associated transmembrane adaptor 1	11.0	Publications
15	TGM1	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
16	TGM6	transglutaminase 6	11.0	Publications
17	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
18	MYO9B	myosin IXB	11.0	Publications
19	DSG3	desmoglein 3	11.0
20	DST	dystonin	11.0	Publications
21	GAD1	glutamate decarboxylase 1 (brain, 67kDa)	11.0	Publications
22	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0	Publications
23	GAST	gastrin	11.0	Publications
24	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
25	CD40LG	CD40 ligand	11.0	Publications
26	IL13	interleukin 13	11.0	Publications
27	SELE	selectin E	11.0	Publications
28	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
29	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
30	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
31	ICAM1	intercellular adhesion molecule 1	11.0	Publications
32	TNF	tumor necrosis factor	11.0	Publications

Pathways related to dermatitis herpetiformis according to GeneDecks:

(show top 50)    (show all 51)

id	Pathway	Score	Top Affiliating Genes
1	Immune response_NFAT in immune response41	10.7	TRAT1
2	Cell adhesion molecules (CAMs)20	10.6	ITGAM
3	Immune response Antigen presentation by MHC class II10	10.2	HLA-DQA1, TRB@
4	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.2	IL2RB, IL2RA
5	Cell adhesion_ECM remodeling41	10.2	PLAU, MMP7, MMP3, MMP12
6	Cell adhesion ECM remodeling10	10.2	PLAU, MMP7, MMP3, MMP12
7	Inhibition of Matrix Metalloproteinases36	10.1	MMP7, MMP3, MMP12
8	Immune response_Antigen presentation by MHC class II41	10.0	TRB@, HLA-DQB1, HLA-DQA1
9	Immune response T cell receptor signaling pathway10	10.0	TRB@, TRAT1, HLA-DQB1, HLA-DQA1
10	Immune response NFAT in immune response10	9.9	CD79A, HLA-DQA1, HLA-DQB1, TRAT1, TRB@
11	Immune response_T cell receptor signaling pathway41	9.9	TRB@, TRAT1, HLA-DQB1, HLA-DQA1
12	Immune response ICOS pathway in T-helper cell10	9.9	TRB@, TRAT1, HLA-DQB1, HLA-DQA1
13	Graft-versus-host disease20	9.9	HLA-DQA1
14	UPA-UPAR Pathway36	9.8	PLAU, FBN1, MMP7, MMP3, MMP12, ITGAM
15	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	IL2RA, IL2RB, TNF
16	NFAT Signaling and Lymphocyte Interactions36	9.7	IL13, IL2RB, IL5, CCL11
17	PGC1Alpha Pathway36	9.7	IL13, IL2RB, IL5, CCL11
18	ICos-ICosL Pathway in T-Helper Cell36	9.7	HLA-DQB1, HLA-DQA1, IL2RB, IL2RA
19	Immune response IL-22 signaling pathway10	9.7	TRB@, HLA-DQB1, HLA-DQA1, IL2RB, IL2RA
20	Immune response_IL-22 signaling pathway41	9.7	TRB@, HLA-DQB1, HLA-DQA1, IL2RB, IL2RA
21	Type I diabetes mellitus20	9.6	GAD1, TNF, HLA-DQB1, HLA-DQA1
22	Leishmaniasis20	9.5	ITGAM, HLA-DQA1, HLA-DQB1, TNF
23	Intestinal immune network for IgA production20	9.5	HLA-DQB1, HLA-DQA1, IL5, CD40LG
24	Autoimmune thyroid disease20	9.5	CD40LG, IL5, HLA-DQA1, HLA-DQB1
25	THC Differentiation Pathway36	9.4	TNF, HLA-DQB1, HLA-DQA1, IL2RA
26	Molecular Mechanisms of Cancer36	9.3	ITGAM, IL13, IL5, FBN1, CCL11
27	Immune System38	9.3	CD79A, IL5, ICAM1
28	Akt Signaling36	9.3	TNF, CCL11, IL2RB, IL2RA, ITGAM
29	Cytokine Network36	9.3	TNF, IL5, IL13
30	Staphylococcus aureus infection20	9.3	HLA-DQB1, HLA-DQA1, ICAM1, ITGAM
31	Viral myocarditis20	9.2	HLA-DQB1, HLA-DQA1, ICAM1, CD40LG
32	Toxoplasmosis20	9.1	CD40LG, HLA-DQA1, HLA-DQB1, TNF
33	Glucocorticoid Receptor Signaling36	9.1	CCL11, IL5, IL2RB, IL2RA, IL13
34	Allograft rejection20	9.0	TNF, HLA-DQB1, HLA-DQA1, IL5, CD40LG
35	MIF Mediated Glucocorticoid Regulation36	9.0	IL13, IL5, CCL11, TNF
36	Hematopoietic cell lineage20	9.0	ITGAM, IL2RA, IL5, TNF
37	TGF-Beta Pathway36	9.0	CCL11, IL5, IL2RB, IL2RA, IL13
38	African trypanosomiasis20	8.9	SELE, ICAM1, TNF
39	Rheumatoid arthritis20	8.9	TNF, HLA-DQB1, HLA-DQA1, ICAM1, MMP3
40	MIF Regulation of Innate Immune Cells36	8.8	TNF, CCL11, IL5, IL13
41	Transendothelial Migration of Leukocytes36	8.8	ICAM1, CCL11, FBN1, MMP7, MMP3, MMP12
42	Malaria20	8.8	TNF, ICAM1, CD40LG, SELE
43	STAT3 Pathway36	8.7	TNF, CCL11, IL5, IL2RB, IL2RA, IL13
44	MAPK Family Pathway36	8.6	TNF, CCL11, IL5, IL2RB, IL2RA, IL13
45	PAK Pathway36	8.6	TNF, CCL11, IL5, IL2RA, IL13, MYO9B
46	Asthma20	8.5	CD40LG, IL13, IL5, CCL11, HLA-DQA1, HLA-DQB1
47	Antioxidant Action of Vitamin-C36	8.5	TNF, CCL11, IL5, IL2RB, IL2RA, IL13
48	Tec Kinases Signaling36	8.5	TNF, CCL11, IL5, IL2RB, IL2RA, IL13
49	Cytokine-cytokine receptor interaction20	8.4	TNF, CCL11, IL5, IL2RB, IL2RA, IL13
50	p38 Signaling36	8.3	TNF, CCL11, IL5, IL2RB, IL2RA, IL13

Compounds related to dermatitis herpetiformis according to GeneDecks:

(show top 50)    (show all 191)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.6	DSG3
2	budesonide32 42 9 9	13.3	CCL11
3	endotoxin32	10.2	ITGAM, CCL11, IL2RB
4	hyaluronic acid32 18	11.1	MMP3, IL13, FBN1
5	glutamate32	10.0	PLAU, GAD1, CD79A, MMP3, TGM2
6	doxycycline32 9 9	11.0	MMP3, PLAU, CD79A, CD40LG, IL13, IL5
7	heparin32 9 18 9	11.9	CD79A, FBN1, ITGAM, GAST, PLAU, CCL11
8	montelukast32 34 9 9	11.9	ITGAM, IL5, CCL11, IL2RA, IL13
9	sulfasalazine32 9 9	10.9	IL2RA, CD40LG, MMP3, CD79A, SELE, TNF
10	pge232	8.9	SELE, MMP3, IL13, IL5, CCL11, PLAU
11	ascorbic acid32 18	9.6	GAST, ITGAM, CD40LG, IL2RA, FBN1
12	erythromycin32 9 9	10.6	GAST, IL5, IL2RB, IL2RA, IL13, CD40LG
13	rolipram32 42	9.6	SELE, TNF, CCL11, IL5, IL13, ITGAM
14	sb 20358032 42	9.5	PLAU, GAST, TNF, CCL11, IL13, MMP3
15	phorbol32	8.5	MMP3, TRB@, TGM1, IL2RA, ICAM1, ITGAM
16	methacholine32 9 9	10.4	CD79A, IL2RB, IL5, CCL11, ICAM1, GAST
17	theophylline32 9 18 9	11.4	ITGAM, CD79A, CD40LG, IL5, IL2RA, IL13
18	neopterin32	8.2	IL2RB, CD40LG, IL2RA, ICAM1, TNF, CD79A
19	calcium32 9 18 9	11.2	MMP12, TRB@, CCL11, FBN1, MMP7, DSG3
20	pentoxifylline32 9 9	10.1	IL2RB, ICAM1, TNF, ITGAM, IL13, IL2RA
21	groalpha32	8.1	IL13, CCL11, ICAM1, TNF, SELE
22	okt332	8.1	SELE, CD79A, CD40LG, IL2RA, IL2RB, ICAM1
23	paraffin32	8.1	DST, MMP7, HLA-DQA1, PLAU, IL2RA, IL5
24	thyroxine32 18	9.0	CD40LG, GAST, APOB, IL2RB, IL13, CD79A
25	epinephrine32 9 18 9	10.9	ITGAM, SELE, CD79A, GAST, PLAU, APOB
26	aspirin32 34 18	9.8	APOB, SELE, CD79A, CD40LG, ITGAM, IL13
27	indomethacin32 9 9	9.8	MMP3, ITGAM, CD40LG, CD79A, CCL11, IL13
28	dextran sulfate32	7.8	MMP7, APOB, ICAM1, PLAU, IL5, CD40LG
29	glutamine32	7.7	GAD1, ITGAM, IL5, MMP3, IL13, GAST
30	thymidine32 18	8.6	IL5, IL13, GAST, ITGAM, TGM1, IL2RB
31	creatinine32	7.5	ITGAM, GAD1, PLAU, APOB, IL2RA, SELE
32	alanine32	7.5	IL13, MMP3, GAD1, CD40LG, IL2RB, FBN1
33	vegf32	7.5	ITGAM, MMP3, MMP7, ICAM1, PLAU, GAST
34	herbimycin a32 42	8.4	IL2RA, CCL11, PLAU, TNF, ICAM1, IL5
35	h2o232	7.3	GAD1, ICAM1, IL5, APOB, ITGAM, IL13
36	rantes32	7.3	IL5, CCL11, ICAM1, IL2RA, IL2RB, IL13
37	atorvastatin32 34 9 18 9	11.2	IL2RA, ITGAM, CD40LG, SELE, ICAM1, APOB
38	n acetylcysteine32	7.2	PLAU, TNF, ICAM1, IL2RB, CD79A, CD40LG
39	polysaccharide32	7.1	ICAM1, PLAU, IL2RA, IL2RB, IL13, SELE
40	fibrinogen32	7.1	TGM2, MMP12, MMP7, APOB, ICAM1, ITGAM
41	prednisolone32 9 9	9.1	GAD1, IL2RA, IL13, MMP3, ITGAM, CD79A
42	lactate32	6.9	CD40LG, APOB, SELE, IL13, CD79A, TNF
43	cyclosporin a32 42	7.6	IL5, CCL11, ICAM1, TRB@, TNF, GAD1
44	retinoic acid32 42 18	8.6	CD79A, FBN1, IL5, IL2RB, IL13, MMP7
45	cycloheximide32	6.5	DST, SELE, PLAU, TNF, ICAM1, ITGAM
46	genistein32 9 18 9	9.2	IL2RB, IL5, CCL11, ICAM1, ITGAM, TNF
47	histamine32 18	7.1	IL2RB, SELE, MMP3, CCL11, IL5, IL2RA
48	tyrosine32	6.1	ICAM1, HLA-DQB1, TRB@, PLAU, DSG3, GAD1
49	serine32	6.1	TNF, SELE, ITGAM, CD40LG, MMP12, MMP3
50	dexamethasone32 42 34 9 9	9.9	MMP12, MMP3, IL13, IL2RA, TNF, ICAM1

Cellular components related to dermatitis herpetiformis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	clathrin-coated endocytic vesicle membrane	GO:030669	9.4	APOB, HLA-DQA1, HLA-DQB1
2	external side of plasma membrane	GO:009897	8.0	TNF, ICAM1, IL2RB, IL13, CD40LG, CD79A
3	extracellular space	GO:005615	6.0	SELE, PLAU, TNF, ICAM1, CCL11, APOB
4	plasma membrane	GO:005886	4.9	HLA-DQB1, TRAT1, TNF, PLAU, DSG3, TGM2

Biological processes related to dermatitis herpetiformis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell envelope organization	GO:043163	10.3	TGM1, TGM3
2	peptide cross-linking	GO:018149	10.1	TGM1, TGM3, TGM6
3	interleukin-2-mediated signaling pathway	GO:038110	10.0	IL2RA, IL2RB
4	regulation of immunoglobulin secretion	GO:051023	9.6	CD40LG, TNF
5	positive regulation of podosome assembly	GO:071803	9.5	IL5, TNF
6	positive regulation of smooth muscle cell proliferation	GO:048661	9.2	TGM2, TNF, IL13
7	positive regulation of B cell proliferation	GO:030890	9.1	CD40LG, IL13, IL5
8	leukocyte cell-cell adhesion	GO:007159	9.0	ICAM1, CD40LG, SELE
9	immune response	GO:006955	8.5	IL13, HLA-DQB1, HLA-DQA1, IGHA1, CCL11, IL5
10	cytokine-mediated signaling pathway	GO:019221	8.5	HLA-DQB1, HLA-DQA1, ICAM1, IL5, IL2RB
11	inflammatory response	GO:006954	8.4	TNF, CCL11, IL5, IL13, CD40LG, SELE

Molecular functions related to dermatitis herpetiformis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-2 receptor activity	GO:004911	9.9	IL2RA, IL2RB
2	protein-glutamine gamma-glutamyltransferase activity	GO:003810	9.5	TGM1, TGM2, TGM3, TGM6