DFSP
MCID: DRM014
MIFTS: 68

Dermatofibrosarcoma Protuberans (DFSP) malady

Genetic diseases, Rare diseases, Skin diseases, Cancer diseases categories
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Summaries for Dermatofibrosarcoma Protuberans

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NIH Rare Diseases:42 Dermatofibrosarcoma protuberans is an uncommon tumor that arises in the skin. the tumor is firm and often flesh-colored although it can be reddish, bluish, or purplish. the tumor is often found on the chest or shoulders, but it can be found on other parts of the body.  dermatofibrosarcoma protuberans may cause no symptoms, and the initial size of the tumor tends to be around 1 to 5 centimeters. this tumor has a low potential to spread to other tissues (metastasize). treatment often involves surgery to remove the tumor, such as by mohs’ micrographic surgery.  last updated: 11/18/2010

MalaCards based summary: Dermatofibrosarcoma Protuberans, also known as dermatofibrosarcoma, is related to merkel cell carcinoma and papilloma, and has symptoms including erythema/erythematous lesions/erythroderma/polymorphous erythema, thick skin/pachydermia/orange skin and subcutaneous nodules/lipomas/tumefaction/swelling. An important gene associated with Dermatofibrosarcoma Protuberans is PDGFB (platelet-derived growth factor beta polypeptide), and among its related pathways are Cytoskeleton remodeling Role of PDGFs in cell migration and PDGFR-beta signaling pathway. The compounds su 6668 and sunitinib malate have been mentioned in the context of this disorder. Affiliated tissues include the dermis laryer of the skin, skin and breast, and related mouse phenotypes are pigmentation and respiratory system.

Disease Ontology:8 A fibrosarcoma that is located in the dermis laryer of the skin and that begins as a hard nodule and grows slowly.

Genetics Home Reference:21 Dermatofibrosarcoma protuberans is a rare type of cancer that causes a tumor in the deep layers of skin. This condition is a type of soft tissue sarcoma, which are cancers that affect skin, fat, muscle, and similar tissues.

Wikipedia:65 Dermatofibrosarcoma protuberans (DFSP) is a very rare tumor. It is a rare neoplasm of the dermis layer... more...

Description from OMIM:46 607907

Aliases & Classifications for Dermatofibrosarcoma Protuberans

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 46OMIM, 44Novoseek, 48Orphanet, 62UMLS, 10DISEASES, 57SNOMED-CT, 34MeSH, 35MESH via Orphanet, 63UMLS via Orphanet
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Dermatofibrosarcoma Protuberans, Aliases & Descriptions:

Name: Dermatofibrosarcoma Protuberans 8 42 21 46 44 48 62
Dermatofibrosarcoma 21 10 44 62
Dfsp 42 21 48
Metastatic Dermatofibrosarcoma Protuberans 42 62
 
Familial Dermatofibrosarcoma Protuberans 42 62
Darier-Hoffmann Tumor 21 62
Darier-Ferrand Tumor 21 62
Giant Cell Fibroblastoma 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Skin diseases


Characteristics (Orphanet epidemiological data):

48
dermatofibrosarcoma protuberans:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Adult


External Ids:

Disease Ontology8 DOID:3507
OMIM46 607907
MESH via Orphanet35 C538219
UMLS via Orphanet63 C0392784

Related Diseases for Dermatofibrosarcoma Protuberans

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Diseases related to Dermatofibrosarcoma Protuberans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1merkel cell carcinoma30.8KIT, MUC1
2papilloma30.7ACTC1
3fibroma30.7DES, F13A1, ACTC1
4fibrosarcoma30.7PDGFRB, ACTC1, DES
5choroid plexus papilloma30.6MUC1, S100B
6fibrous histiocytoma30.5DES, S100B, ACTC1, F13A1
7kaposi's sarcoma30.5PDGFB, F13A1
8meningioma30.1MUC1, S100B, PDGFRB, PDGFB
9adenocarcinoma29.9F13A1, MUC1, PDGFB, PDGFRB, ACTC1
10gastrointestinal stromal tumor29.6KIT, S100B, DES, ACTC1, PDGFRB
11giant cell tumor29.6S100B, F13A1, MUC1, ACTC1, DES
12sarcoma29.4F13A1, MUC1, ACTC1, PDGFRB, PDGFB, S100B
13melanoma29.1F13A1, DES, ACTC1, PDGFRB, PDGFB, S100B
14histiocytoma10.6
15carney triad10.5KIT
16fasciitis10.5ACTC1
17histiocytosis10.4S100B
18encephalocele10.4
19myelofibrosis10.4PDGFRB
20burn scar10.4
21burns10.4
22spindle cell lipoma10.4
23lipoma10.4
24pancreatitis10.4
25bednar's tumor10.4
26ganglioglioma10.4S100B
27gingival overgrowth10.3COL1A1, PDGFB
28infantile myofibromatosis10.3DES
29hemangioma10.3ACTC1, F13A1
30juvenile xanthogranuloma10.3S100B, F13A1
31renal fibrosis10.3PDGFB, PDGFRB
32gynecomastia10.3
33langerhans-cell histiocytosis10.3S100B, F13A1
34malignant mixed mullerian tumor10.2PDGFRB, KIT
35systemic mastocytosis10.2KIT, PDGFRB
36arteriovenous fistula10.2
37keloids10.2
38mycosis fungoides10.2
39shwachman-diamond syndrome10.2
40sinusitis10.2
41wilms tumor10.2
42acquired immunodeficiency syndrome10.2
43malignant giant cell tumor of soft parts10.2
44adenosine deaminase deficiency10.2
45cushing's syndrome10.2
46duodenitis10.2
47choroiditis10.2
48adult fibrosarcoma10.2
49breast cancer10.2
50cervicitis10.2

Graphical network of the top 20 diseases related to Dermatofibrosarcoma Protuberans:



Diseases related to dermatofibrosarcoma protuberans

Symptoms for Dermatofibrosarcoma Protuberans

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Clinical features from OMIM:

607907

Symptoms:

48
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • thick skin/pachydermia/orange skin
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • skin/cutaneous neoplasm/tumor/carcinoma/cancer (excluding melanoma)
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • chronic skin infection/ulcerations/ulcers/cancrum

HPO human phenotypes related to Dermatofibrosarcoma Protuberans:

id Description Frequency HPO Source Accession
1 thickened skin hallmark (90%) HP:0001072
2 neoplasm of the skin hallmark (90%) HP:0008069
3 sarcoma hallmark (90%) HP:0100242
4 skin ulcer typical (50%) HP:0200042

Drugs & Therapeutics for Dermatofibrosarcoma Protuberans

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Drug clinical trials:

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Genetic Tests for Dermatofibrosarcoma Protuberans

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Anatomical Context for Dermatofibrosarcoma Protuberans

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MalaCards organs/tissues related to Dermatofibrosarcoma Protuberans:

32
Skin, Breast, Lung, Bone, Lymph node, Pancreas, Testes, Endothelial

FMA organs/tissues related to Dermatofibrosarcoma Protuberans:

14
The dermis laryer of the skin

Animal Models for Dermatofibrosarcoma Protuberans or affiliated genes

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Publications for Dermatofibrosarcoma Protuberans

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Articles related to Dermatofibrosarcoma Protuberans:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Dermatofibrosarcoma protuberans, version 1.2014. (24925197)
2014
2
Dermatofibrosarcoma protuberans in children and adolescents: Clinical presentation, histology, treatment, and review of the literature. (24973861)
2014
3
Truncal myxoid Dermatofibrosarcoma Protuberans in a 11-month old child. (25163850)
2014
4
Outcome of wide local excision in dermatofibrosarcoma protuberans and use of radiotherapy for margin-positive disease. (23741663)
2013
5
Dermatofibrosarcoma protuberans in a 10-year-old child. (24421865)
2013
6
Painful late recurrence of dermatofibrosarcoma protuberans of breast in a centurian female. (24298499)
2013
7
CD99 Expression in Dermatofibrosarcoma Protuberans and Dermatofibroma. (24247571)
2013
8
Magnetic resonance imaging of vulvar dermatofibrosarcoma protuberans - report of a case. (24133389)
2013
9
Reply to "More evidence that genetic profiling will delineate the nosology and biologic potential of fibrohistiocytic tumors in the dermatofibrosarcoma protuberans spectrum". (23602189)
2013
10
Practice gaps. Underuse of Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans: comment on "efficacy of mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans". (22986860)
2012
11
Dermatofibrosarcoma protuberans: Our experience of 59 cases. (23162649)
2012
12
Dermatofibrosarcoma protuberans in childhood. (23154247)
2012
13
Treatment of advanced dermatofibrosarcoma protuberans with imatinib mesylate with or without surgical resection. (20569296)
2011
14
Molecular diagnosis of dermatofibrosarcoma protuberans: a comparison between reverse transcriptase-polymerase chain reaction and fluorescence in situ hybridization methodologies. (21484928)
2011
15
Recurrent bilateral dermatofibrosarcoma protuberans of eyelids. (21346665)
2011
16
A case of childhood dermatofibrosarcoma protuberans of the face. (21763849)
2011
17
Dermatofibrosarcoma protuberans with areas of giant cell fibroblastoma in the vulva: a case report. (21319518)
2010
18
A novel COL1A1 exon 14/PDGFB fusion gene in dermatofibrosarcoma protuberans. (20133221)
2010
19
Imaging of dermatofibrosarcoma protuberans of breast. (20626395)
2010
20
Imatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trials. (20194851)
2010
21
Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans. (20559119)
2010
22
Dermatofibrosarcoma protuberans of the breast skin. (21091837)
2010
23
Surgical treatment for dermatofibrosarcoma protuberans: the Dartmouth experience and literature review. (18443511)
2008
24
Short German guidelines: dermatofibrosarcoma protuberans. (18801137)
2008
25
Atrophic dermatofibrosarcoma protuberans with the fusion gene COL1A1-PDGFB. (18005119)
2008
26
Mohs micrographic surgery and dermatofibrosarcoma protuberans: a multidisciplinary approach in 44 patients. (18520205)
2008
27
Myxoid dermatofibrosarcoma protuberans: a rare variant analyzed in a series of 23 cases. (17721193)
2007
28
Dermatofibrosarcoma protuberans and small bowel adenocarcinoma: coincidental occurrence or genetic association? (18175227)
2006
29
Dermatofibrosarcoma protuberans: report of a case with a variant ring chromosome and metastases following pregnancy. (16640548)
2006
30
Dermatofibrosarcoma protuberans arising in a decorative tattoo. (18521416)
2005
31
Dermatofibrosarcoma protuberans occuring in a child. (15943042)
2005
32
Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225. (15681532)
2005
33
Molecularly targeted treatment for dermatofibrosarcoma protuberans. (15176002)
2004
34
Dermatofibrosarcoma protuberans: a report on 29 patients treated by Mohs micrographic surgery with long-term follow-up and review of the literature. (15221986)
2004
35
Neurofibromatous changes in dermatofibrosarcoma protuberans: a potential pitfall in the diagnosis of a serious cutaneous soft tissue neoplasm. (15239679)
2004
36
Dermatofibrosarcoma protuberans arising from a burn scar of the axilla. (15084891)
2004
37
Dermatofibrosarcoma protuberans. (15503305)
2004
38
Giant fibrosarcoma arising in dermatofibrosarcoma protuberans on the scalp during pregnancy. (12614428)
2003
39
Dermatofibrosarcoma protuberans of the vulva and groin: detection of COL1A1-PDGFB fusion transcripts by RT-PCR. (12641779)
2003
40
COL1A1-PDGFB gene fusion demonstrates a common histogenetic origin for dermatofibrosarcoma protuberans and its granular cell variant. (12131162)
2002
41
Composite dermatofibrosarcoma protuberans-giant cell fibroblastoma recurring as BednA!r tumor-giant cell fibroblastoma with mucoid lakes and with amputation neuroma. (12629865)
2002
42
Dermatofibrosarcoma protuberans: experience with 14 cases. (11763383)
2001
43
Dermatofibrosarcoma protuberans: A clinicopathologic analysis of patients treated and followed at a single institution. (10870053)
2000
44
A morphologic study of dermatofibrosarcoma protuberans: expansion of a histologic profile. (10774935)
2000
45
Dermatofibrosarcoma protuberans of the head and neck. (11034249)
2000
46
Dermatofibrosarcoma protuberans: what is the best surgical approach? (11128831)
1999
47
Darier-White disease and dermatofibrosarcoma protuberans. (10592418)
1999
48
Acral dermatofibrosarcoma protuberans with metastases. (10029491)
1999
49
A cutaneous case of giant cell angiofibroma occurring with dermatofibrosarcoma protuberans and showing bimodal CD34+ fibroblastic and FXIIIa+ histiocytic immunophenotype. (9696292)
1998
50
Sclerosing dermatofibrosarcoma protuberans. (9826170)
1998

Variations for Dermatofibrosarcoma Protuberans

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Clinvar genetic disease variations for Dermatofibrosarcoma Protuberans:

6
id Gene Name Type Significance SNP ID Assembly Location
1PDGFBPDGFB, PDGFB/COL1A1 FUSIONundetermined variantPathogenic

Expression for genes affiliated with Dermatofibrosarcoma Protuberans

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Expression patterns in normal tissues for genes affiliated with Dermatofibrosarcoma Protuberans

Search GEO for disease gene expression data for Dermatofibrosarcoma Protuberans.

Pathways for genes affiliated with Dermatofibrosarcoma Protuberans

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Pathways related to Dermatofibrosarcoma Protuberans according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
PDGF Pathway37
9.7PDGFRB, PDGFB
29.7PDGFB, PDGFRB
39.7PDGFB, PDGFRB
49.5ACTC1, KIT
59.4PDGFRB, PDGFB, COL1A1
6
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
9.4PDGFB, PDGFRB, COL1A1
7
Show member pathways
9.2KIT, PDGFRB, PDGFB
8
Show member pathways
9.2PDGFRB, PDGFB, KIT
9
Show member pathways
9.2PDGFRB, PDGFB, KIT
10
Show member pathways
9.2PDGFRB, PDGFB, KIT
119.2PDGFB, PDGFRB, KIT
12
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.2KIT, PDGFRB, COL1A1
13
Show member pathways
9.2ACTC1, DES
148.9COL1A1, KIT, PDGFB, PDGFRB
15
Show member pathways
8.9COL1A1, PDGFRB, PDGFB, KIT
16
Show member pathways
8.7KIT, PDGFRB, S100B, PDGFB
17
Show member pathways
7.4PDGFRB, PDGFB, COL1A1, MUC1, DES, KIT

Compounds for genes affiliated with Dermatofibrosarcoma Protuberans

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Compounds related to Dermatofibrosarcoma Protuberans according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1su 66686110.1PDGFRB, PDGFB
2sunitinib malate6110.0PDGFRB, PDGFB
3su 16f6110.0PDGFB, PDGFRB
4dmpq dihydrochloride6110.0PDGFB, PDGFRB
5su6668449.9KIT, PDGFRB
6zd6474449.8PDGFRB, KIT
7pkc 412449.7PDGFRB, KIT
8ag-1296449.6KIT, PDGFRB
9eosin449.6MUC1, S100B
10su5416449.5PDGFRB, KIT
11capecitabine44 50 1111.5PDGFRB, KIT
12silver449.3PDGFB, DES, F13A1
13orcein449.1DES, ACTC1, S100B
14chloramphenicol44 2 50 1112.0MUC1, COL1A1, S100B, PDGFB
15toluidine449.0DES, KIT
16agarose448.9KIT, MUC1, S100B
17oligonucleotide448.9F13A1, COL1A1, PDGFRB, KIT, PDGFB
18biotin44 24 1110.8ACTC1, DES, MUC1
19valine448.8COL1A1, KIT, S100B
20bromodeoxyuridine448.8PDGFRB, PDGFB, DES, S100B
21gold448.7KIT, DES, MUC1
22procollagen448.6PDGFB, COL1A1, ACTC1, F13A1, DES
23iron44 249.6ACTC1, S100B, F13A1, DES
24dexamethasone44 50 28 1111.6MUC1, S100B, COL1A1, ACTC1, PDGFB
25methionine448.6S100B, DES, KIT, PDGFRB
26mucicarmine448.5S100B, MUC1, DES, ACTC1
27creatinine448.3DES, ACTC1, MUC1, S100B
28ribonucleic acid448.2PDGFB, COL1A1, KIT, ACTC1, MUC1, PDGFRB
29s 100448.1DES, F13A1, MUC1, ACTC1, S100B
30reticulin448.1MUC1, ACTC1, F13A1, DES, S100B
31b 723448.1S100B, ACTC1, MUC1, F13A1, DES
32nitric oxide44 24 1110.0S100B, KIT, PDGFB, MUC1, DES
33formaldehyde44 249.0DES, KIT, ACTC1, MUC1, S100B
34glycogen44 248.9ACTC1, S100B, MUC1, KIT, DES
35threonine447.9S100B, KIT, PDGFRB, MUC1, DES
36thymidine44 248.7MUC1, DES, COL1A1, S100B, PDGFB, KIT
37oxygen44 248.7PDGFRB, S100B, MUC1, PDGFB, ACTC1, DES
38cysteine447.6COL1A1, PDGFRB, MUC1, KIT, DES, S100B
39hematoxylin447.6DES, MUC1, ACTC1, F13A1, S100B, KIT
40imatinib44 50 119.5KIT, S100B, PDGFB, PDGFRB, COL1A1, ACTC1
41testosterone44 61 24 1110.5S100B, KIT, PDGFRB, ACTC1, DES, MUC1
42serine447.3DES, S100B, PDGFB, KIT, MUC1, PDGFRB
43glucose447.2ACTC1, PDGFRB, PDGFB, S100B, MUC1, DES
44retinoic acid44 248.2ACTC1, MUC1, COL1A1, PDGFRB, S100B, KIT
45tyrosine447.2DES, MUC1, ACTC1, PDGFB, S100B, KIT
46paraffin446.9ACTC1, MUC1, F13A1, DES, PDGFB, S100B
47progesterone44 28 61 24 1110.9MUC1, F13A1, ACTC1, PDGFRB, PDGFB, S100B
48calcium44 50 24 119.8MUC1, DES, F13A1, ACTC1, COL1A1, PDGFRB
49vegf446.5KIT, DES, F13A1, MUC1, S100B, PDGFB
50estrogen446.5MUC1, PDGFB, KIT, S100B, PDGFRB, COL1A1

GO Terms for genes affiliated with Dermatofibrosarcoma Protuberans

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Cellular components related to Dermatofibrosarcoma Protuberans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.8PDGFB, F13A1
2extracellular spaceGO:0056158.0KIT, S100B, PDGFB, COL1A1, ACTC1

Biological processes related to Dermatofibrosarcoma Protuberans according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular mesangial cell proliferation involved in metanephros developmentGO:07226210.1PDGFB, PDGFRB
2positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayGO:03579310.1PDGFB, PDGFRB
3positive regulation of DNA biosynthetic processGO:200057310.1PDGFB, PDGFRB
4positive regulation of calcium ion importGO:09028010.1PDGFRB, PDGFB
5positive regulation of chemotaxisGO:05092110.1PDGFRB, PDGFB
6positive regulation of smooth muscle cell migrationGO:01491110.0PDGFB, PDGFRB
7positive regulation of reactive oxygen species metabolic processGO:200037910.0PDGFRB, PDGFB
8platelet-derived growth factor receptor signaling pathwayGO:0480089.9PDGFRB, PDGFB
9cardiac myofibril assemblyGO:0550039.9ACTC1, PDGFRB
10positive regulation of mitosisGO:0458409.9PDGFB, PDGFRB
11positive regulation of phospholipase C activityGO:0108639.9KIT, PDGFRB
12response to hydrogen peroxideGO:0425429.8COL1A1, PDGFRB
13response to estradiolGO:0323559.8COL1A1, PDGFRB, PDGFB
14positive regulation of smooth muscle cell proliferationGO:0486619.7PDGFB, PDGFRB
15platelet activationGO:0301689.7PDGFB, COL1A1, F13A1
16positive regulation of MAP kinase activityGO:0434069.6PDGFB, PDGFRB
17positive regulation of MAPK cascadeGO:0434109.6KIT, PDGFB
18positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.6PDGFRB, PDGFB, KIT
19cell chemotaxisGO:0603269.6PDGFRB, PDGFB, KIT
20positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6KIT, PDGFB, PDGFRB
21peptidyl-tyrosine phosphorylationGO:0181089.6KIT, PDGFB, PDGFRB
22phosphatidylinositol-mediated signalingGO:0480159.5PDGFRB, PDGFB, KIT
23fibroblast growth factor receptor signaling pathwayGO:0085439.5PDGFRB, PDGFB, KIT
24Fc-epsilon receptor signaling pathwayGO:0380959.5PDGFRB, PDGFB, KIT
25epidermal growth factor receptor signaling pathwayGO:0071739.5KIT, PDGFB, PDGFRB
26neurotrophin TRK receptor signaling pathwayGO:0480119.4PDGFRB, PDGFB, KIT
27hemopoiesisGO:0300979.3KIT, PDGFB
28muscle filament slidingGO:0300499.3ACTC1, DES
29positive regulation of cell migrationGO:0303359.3KIT, PDGFB, PDGFRB, COL1A1
30positive regulation of cell proliferationGO:0082849.1PDGFRB, PDGFB, S100B, KIT
31innate immune responseGO:0450879.0KIT, S100B, PDGFB, PDGFRB

Molecular functions related to Dermatofibrosarcoma Protuberans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor bindingGO:0051619.4PDGFB, PDGFRB
2platelet-derived growth factor bindingGO:0484079.4COL1A1, PDGFRB, PDGFB
3identical protein bindingGO:0428028.4DES, COL1A1, PDGFB, S100B
4protein bindingGO:0055156.9MUC1, COL1A1, PDGFRB, PDGFB, S100B, KIT

Products for genes affiliated with Dermatofibrosarcoma Protuberans

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Sources for Dermatofibrosarcoma Protuberans

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet