DM
MCID: DRM010
MIFTS: 70

Dermatomyositis (DM) malady

Neuronal diseases, Nephrological diseases, Bone diseases, Skin diseases categories

Summaries for Dermatomyositis

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Dermatomyositis is one of a group of acquired muscle diseases called inflammatory myopathies (disorder of muscle tissue or muscles), which are characterized by chronic muscle inflammation accompanied by muscle weakness. the cardinal symptom is a skin rash that precedes or accompanies progressive muscle weakness. dermatomyositis may occur at any age, but is most common in adults in their late 40s to early 60s, or children between 5 and 15 years of age. there is no cure for dermatomyositis, but the symptoms can be treated. options include medication, physical therapy, exercise, heat therapy (including microwave and ultrasound), orthotics and assistive devices, and rest. the cause of dermatomyositis is unknown. last updated: 8/26/2013

MalaCards: Dermatomyositis, also known as polymyositis with skin involvement, is related to adult dermatomyositis and interstitial lung disease, and has symptoms including lymphoma, vascularitis/vasculitides/arteritis and biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp. An important gene associated with Dermatomyositis is IFIH1 (interferon induced with helicase C domain 1), and among its related pathways are Immune System and Interferon Signaling. The compounds pyrophosphate and Adenosine triphosphate have been mentioned in the context of this disorder. Affiliated tissues include muscle or, skin and lung.

Disease Ontology:8 A myositis that results in inflammation located in muscle or located in skin where a skin rash is often seen prior to the onset of muscle weakness. the disease may result from either a viral infection or an autoimmune reaction.

NINDS:43 Dermatomyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.

Wikipedia:63 Dermatomyositis (DM) is a connective-tissue disease related to polymyositis (PM) that is characterized... more...

Description from OMIM:46 160750

Aliases & Classifications for Dermatomyositis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

48
dermatomyositis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

dermatomyositis 8 42 43 10 44 48 46
polymyositis with skin involvement 8
dermatopolymyositis, unspecified 8
adult-onset dermatomyositis 48
adult type dermatomyositis 60
dermatopolymyositis 8
dm 48


External Ids:

Disease Ontology8 DOID:10223
NCIt39 C26744
ICD9CM27 710.3
SNOMED-CT via Orphanet57 396230008, 402425006, 396229003
UMLS via Orphanet61 C0011633
MESH via Orphanet35 D003882
ICD10 via Orphanet26 M33.0, M33.1
OMIM46 160750
ICD1025 M33, M33.9

Related Diseases for Dermatomyositis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Dermatomyositis family:

Adult Dermatomyositis

Diseases related to Dermatomyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 273)
idRelated DiseaseScoreTop Affiliating Genes
1adult dermatomyositis31.2IFIT3, UBA2
2interstitial lung disease31.1SFTPD, HARS
3myositis31.0ICAM1, HARS, PIK3C2A, CHKB, VCAM1, GARS
4pneumonia30.7PIK3C2A, ICAM1, SFTPD
5inclusion body myositis30.7VCAM1, ICAM1
6myopathy30.6PIK3C2A, CHKB, GARS
7systemic lupus erythematosus30.6ICAM1, VCAM1, CCR7, HLA-DQA1
8diabetes mellitus30.6IFIH1, ICAM1, HLA-DQA2, HLA-DQA1, PIK3C2A, VCAM1
9arthritis30.6ICAM1, CCR7
10melanoma30.5IFIH1, CCR7, ICAM1, CHKB, VCAM1
11rheumatoid arthritis30.4SFTPD, ICAM1, CHKB, CCR7, VCAM1
12connective tissue disease30.2VCAM1, ICAM1
13dermatitis30.0HARS, ICAM1, PIK3C2A, VCAM1
14influenza30.0CCR7, IFIH1, SFTPD
15psoriasis30.0VCAM1, ICAM1, CCR7
16tuberculosis30.0CCR7, SFTPD
17celiac disease29.8HLA-DQA1, HLA-DQA2
18polymyositis29.7ICAM1, CCR7, SFTPD, HARS, PIK3C2A, CHKB
19sarcoidosis29.6SFTPD, ICAM1
20respiratory failure29.6SFTPD, ICAM1, PIK3C2A
21calcinosis10.7
22lupus erythematosus10.5
23myotonic dystrophy10.4
24childhood type dermatomyositis10.4
25scleroderma10.4
26skin disease10.4
27panniculitis10.3
28amyopathic dermatomyositis10.3
29breast cancer10.2
30systemic scleroderma10.2
31adenocarcinoma10.2
32maturity-onset diabetes of the young10.2
33multicentric reticulohistiocytosis10.2
34pneumatosis cystoides intestinalis10.2
35fasciitis10.2
36lipodystrophy10.2
37testicular cancer10.2
38pityriasis rubra pilaris10.1
39nasopharyngitis10.1
40bladder carcinoma10.1
41vasculitis10.1
42diabetes insipidus10.1
43acute interstitial pneumonia10.1
44cutaneous lupus erythematosus10.1
45pemphigus10.1
46arthropathy10.1
47esophagitis10.1
48glomerulonephritis10.1
49hypertrichosis10.1
50lung cancer10.1

Graphical network of the top 20 diseases related to Dermatomyositis:



Diseases related to dermatomyositis

Clinical Features for Dermatomyositis

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

160750

Symptoms:

48 (show all 50)
  • lymphoma
  • vascularitis/vasculitides/arteritis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • skin hypoplasia/aplasia/atrophy
  • neoplasms/tumors
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • palpebral edema/periorbital edema
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • eosinophils anomalies/hypereosinophilia
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • telangiectasic erythema/poikiloderma
  • gastrointestinal stromal tumor
  • fever/chilling
  • anomalies of eyelids, eyelashes and lacrimal system
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • dry/squaly skin/exfoliation
  • cardiac rhythm disorder/arrhythmia
  • abnormal emg/electromyogram/electropmyography
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • nails anomalies
  • lung fibrosis
  • abnormal cry/voice/phonation disorder/nasal speech
  • articular/joint pain/arthralgia
  • asthenia/fatigue/weakness
  • arthritis/synovitis/synovial proliferation
  • repeat respiratory infections
  • muscle weakness/flaccidity
  • hypotonia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • elocution disorders/dysarthria/dysphonia
  • chronic skin infection/ulcerations/ulcers/cancrum
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • follicular/erythematous/edematous papules/milium
  • myocardium anomalies/myocarditis
  • pulmonary hypertension
  • periarticular tissue anomaly/extraarticular calcifications
  • angor pectoris/myocardial infarction
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • autoimmunity/autoimmune reaction/autoantibodies
  • myalgia/muscular pain
  • gangrena/necrosis
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • cough
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • skin photosensitivity
  • telangiectasiae of the skin
  • cutaneous edema
  • pruritus/itching
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia

Drugs & Therapeutics for Dermatomyositis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dermatomyositis

Drug clinical trials:

Search ClinicalTrials for Dermatomyositis

Search NIH Clinical Center for Dermatomyositis

Search CenterWatch for Dermatomyositis

Genetic Tests for Dermatomyositis

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Anatomical Context for Dermatomyositis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Dermatomyositis:

32
Skin, Lung, Heart, Breast, T cells, Bone, Testes, Ovary, Thyroid, Monocytes, Endothelial, Tongue, B cells, Colon, Prostate, Skeletal muscle, Appendix, Brain, Liver, Myeloid

FMA organs/tissues related to Dermatomyositis:

14
Muscle or

Animal Models for Dermatomyositis or affiliated genes

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Publications for Dermatomyositis

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Sources:
50PubMed
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Articles related to Dermatomyositis:

(show top 50)    (show all 1016)
idTitleAuthorsYear
1
Amyopathic dermatomyositis-associated bilateral elbow ulcers successfully treated with autologous platelet-rich plasma. (23451997)
2014
2
Gemcitabine-induced radiation recall myositis in a patient with dermatomyositis. (24283707)
2013
3
Low prevalence of anti-DFS70/LEDGF antibodies in patients with dermatomyositis and other systemic autoimmune rheumatic diseases. (23280167)
2013
4
Immunogenicity of the bivalent human papillomavirus vaccine in adolescents with juvenile systemic lupus erythematosus or juvenile dermatomyositis. (23997002)
2013
5
Calcinosis universalis complicating juvenile dermatomyositis: improvement after intravenous immunoglobulin therapy. (22999904)
2013
6
Successful polymyxin B hemoperfusion treatment associated with serial reduction of serum anti-CADM-140/MDA5 antibody levels in rapidly progressive interstitial lung disease with amyopathic dermatomyositis. (24297126)
2013
7
Recurrent pneumatosis intestinalis in a patient with dermatomyositis. (23975922)
2013
8
Childhood dermatomyositis recurring in adulthood half a century later. (24000211)
2013
9
Fascin-expressing dendritic cells dominate in polymyositis and dermatomyositis. (23118112)
2013
10
Anti-melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum. (23436757)
2013
11
Lack of sustained response of advanced dermatomyositis to autologous haematopoietic cell transplantation. (24172043)
2013
12
Pilot study of etanercept in patients with refractory juvenile dermatomyositis. (24127327)
2013
13
Clinical presentation and evaluation of dermatomyositis. (23112358)
2012
14
Organ-specific autoantibodies and autoimmune diseases in juvenile systemic lupus erythematosus and juvenile dermatomyositis patients. (22261392)
2012
15
KL-6: a serological biomarker for interstitial lung disease in patients with polymyositis and dermatomyositis. (21950266)
2012
16
Recurrent ventricular tachycardia in a child with juvenile dermatomyositis - an unusual association. (22462430)
2012
17
Different microvascular involvement in dermatomyositis and systemic sclerosis. A preliminary study by a tight videocapillaroscopic assessment. (22691212)
2012
18
Spontaneous pneumomediastinum associated with laryngeal lesions and tracheal ulcer in dermatomyositis. (23090379)
2012
19
Paget's Disease of the Breast in a Patient with Amyopathic Dermatomyositis. (23049567)
2012
20
Efficacy of rocuronium and sugammadex in a patient with dermatomyositis. (22419633)
2012
21
A severe case of universal calcinosis with juvenile dermatomyositis. (23075660)
2012
22
Ovarian teratoma mimicking features of juvenile dermatomyositis in a child. (21969283)
2011
23
Dermatomyositis as the initial presentation of a large anaplastic T-cell lymphoma. (21343565)
2011
24
Idiopathic inflammatory myopathy associated with malignancy: a retrospective cohort of 151 Korean patients with dermatomyositis and polymyositis. (21844145)
2011
25
Polymyositis, dermatomyositis, and autoimmune necrotizing myopathy: clinical features. (21444016)
2011
26
Incidence of dermatomyositis and clinically amyopathic dermatomyositis: a population-based study in Olmsted County, Minnesota. (20083689)
2010
27
Efficacy of thalidomide in a girl with inflammatory calcinosis, a severe complication of juvenile dermatomyositis. (20181085)
2010
28
Hydroxyurea-associated dermatomyositis-like eruption demonstrating abnormal epidermal p53 expression: a potential premalignant manifestation of chronic hydroxyurea and UV radiation exposure. (20231502)
2010
29
Long-term outcome of patients with polymyositis/ dermatomyositis and anti-PM-Scl antibody. (19845665)
2010
30
Drug treatment of polymyositis and dermatomyositis. (20228455)
2010
31
Calcinosis cutis associated with amyopathic dermatomyositis: response to intravenous immunoglobulin. (19467386)
2009
32
Interstitial lung disease in polymyositis and dermatomyositis. (19247576)
2009
33
An extremely severe case of cutaneous calcinosis complicating adult dermatomyositis. (19076816)
2009
34
Distribution and severity of weakness among patients with polymyositis, dermatomyositis and juvenile dermatomyositis. (19074186)
2009
35
Calcinosis in juvenile dermatomyositis: a possible role for the vitamin K-dependent protein matrix Gla protein. (18234711)
2008
36
Calcinosis cutis of juvenile dermatomyositis treated with incision and drainage. (18248486)
2008
37
Successful treatment of refractory rash in paraneoplastic amyopathic dermatomyositis. (16779504)
2007
38
Calcinosis cutis universalis with joint contractures complicating juvenile dermatomyositis. (16707900)
2006
39
Signs of inflammation in both symptomatic and asymptomatic muscles from patients with polymyositis and dermatomyositis. (16831829)
2006
40
Role of endothelial damage in the pathogenesis of interstitial pneumonitis in patients with polymyositis and dermatomyositis. (16652421)
2006
41
Difference in adhesion molecule expression (ICAM-1 and VCAM-1) in juvenile and adult dermatomyositis, polymyositis and inclusion body myositis. (16431335)
2006
42
Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. (15856462)
2005
43
Amyopathic dermatomyositis presenting during pregnancy. (15523374)
2004
44
Pemphigus foliaceus in an 11-year-old boy with dermatomyositis: simple coincidence or familial immunological background? (12752161)
2003
45
Mannose binding lectin (MBL) polymorphisms associated with low MBL production in patients with dermatomyositis. (12485445)
2002
46
Association of HLA-DQB1 alleles and dermatomyositis/ polymyositis]. (12170471)
2002
47
Amyopathic dermatomyositis: report of three cases. (9990389)
1998
48
Amyopathic dermatomyositis in Hong Kong -- association with nasopharyngeal carcinoma. (9762814)
1998
49
Low-dose methotrexate as an adjunctive therapy with surgery for ectropion complicating dermatomyositis. (8829501)
1996
50
Amyopathic dermatomyositis: a review. (8423381)
1993

Genetic Variations for Dermatomyositis

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Expression for genes affiliated with Dermatomyositis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dermatomyositis

Search GEO for disease gene expression data for Dermatomyositis.

Pathways for genes affiliated with Dermatomyositis

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Sources:
53Reactome, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Dermatomyositis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Dermatomyositis according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1pyrophosphate44 2412.2CMAS, UBA2, KARS, HARS, GARS, PIK3C2A
2Adenosine triphosphate11 2412.2UBA2, KARS, HARS, GARS, PIK3C2A, CHKB
3phosphoric acid44 2412.2UBA2, KARS, HARS, GARS, IARS, CMAS
4Adenosine monophosphate11 2412.1UBA2, KARS, HARS, GARS, IARS
5polysaccharide4411.1SFTPD, ICAM1, CHKB, CMAS, VCAM1
6fluvastatin44 49 28 1114.1ICAM1, PIK3C2A, CHKB, VCAM1
7pravastatin44 49 28 11 2415.1VCAM1, CHKB, PIK3C2A, ICAM1
8alanine4411.0CCR7, KARS, GARS, PIK3C2A, CHKB, VCAM1
9atorvastatin44 49 28 11 2415.0VCAM1, CHKB, PIK3C2A, ICAM1
10prednisolone44 28 1113.0VCAM1, CHKB, PIK3C2A, SFTPD
11simvastatin44 49 59 28 11 2416.0ICAM1, PIK3C2A, CHKB, VCAM1
12lactate4411.0SFTPD, ICAM1, PIK3C2A, CHKB, VCAM1
13endotoxin4411.0SFTPD, ICAM1, CHKB, VCAM1
14aminoacyl-trna4411.0KARS, GARS, IARS
15budesonide44 49 1113.0SFTPD, ICAM1, VCAM1
16cerivastatin44 49 28 1114.0CHKB, PIK3C2A, ICAM1
17trna4410.9IARS, GARS, KARS
18fenofibrate44 49 1112.9VCAM1, PIK3C2A, ICAM1
19alpha-hydroxybutyrate4410.9PIK3C2A, CHKB
20thallium4410.9PIK3C2A, CHKB
21fibrinogen4410.9ICAM1, PIK3C2A, CHKB, VCAM1
22tetramethylpyrazine4410.8CHKB, ICAM1
23hydroxylysine4410.8SFTPD, CHKB
24sodium cromoglycate4410.8VCAM1, ICAM1
25dantrolene44 28 1112.8CHKB, PIK3C2A
26succinylcholine44 28 1112.7CHKB, PIK3C2A
278 methoxypsoralen4410.7VCAM1, ICAM1
28loratadine44 11 2412.6VCAM1, ICAM1
29anticodon4410.6GARS, KARS
30norepinephrine44 11 2412.6CCR7, CHKB
31gamma-hydroxybutyrate4410.5CHKB, PIK3C2A
32sele4410.3VCAM1, ICAM1

GO Terms for genes affiliated with Dermatomyositis

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Sources:
16Gene Ontology
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Cellular components related to Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.9IFIT3, IFIH1, UBA2, KARS, HARS, GARS
2cytosolGO:00582910.9IFIT3, IFIH1, KARS, HARS, GARS, PIK3C2A
3ER to Golgi transport vesicle membraneGO:01250710.7STX17, HLA-DQA1, HLA-DQA2
4NuRD complexGO:01658110.6CHD4, CHD3
5MHC class II protein complexGO:04261310.3HLA-DQA1, HLA-DQA2

Biological processes related to Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tRNA aminoacylation for protein translationGO:00641810.8IARS, GARS, HARS, KARS
2interferon-gamma-mediated signaling pathwayGO:06033310.7ICAM1, HLA-DQA2, HLA-DQA1, VCAM1
3cytokine-mediated signaling pathwayGO:01922110.7IFIT3, ICAM1, HLA-DQA2, HLA-DQA1, VCAM1
4modulation by virus of host morphology or physiologyGO:01904810.7VCAM1, KARS, ICAM1, IFIH1
5diadenosine tetraphosphate biosynthetic processGO:01596610.5GARS, KARS
6membrane to membrane dockingGO:02261410.3ICAM1, VCAM1

Molecular functions related to Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00552410.7IARS, IFIH1, UBA2, KARS, HARS, GARS
2MHC class II receptor activityGO:03239510.6HLA-DQA1, HLA-DQA2

Products for genes affiliated with Dermatomyositis

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  • Antibodies
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Sources for Dermatomyositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet