MCID: DRM010
MIFTS: 62

Dermatomyositis malady

Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Skin diseases categories

Summaries for Dermatomyositis

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NIH Rare Diseases:41 Dermatomyositis is one of a group of acquired muscle diseases called inflammatory myopathies (disorder of muscle tissue or muscles), which are characterized by chronic muscle inflammation accompanied by muscle weakness. the cardinal symptom is a skin rash that precedes or accompanies progressive muscle weakness. dermatomyositis may occur at any age, but is most common in adults in their late 40s to early 60s, or children between 5 and 15 years of age. there is no cure for dermatomyositis, but the symptoms can be treated. options include medication, physical therapy, exercise, heat therapy (including microwave and ultrasound), orthotics and assistive devices, and rest. the cause of dermatomyositis is unknown. last updated: 8/26/2013

MalaCards based summary: Dermatomyositis, also known as polymyositis with skin involvement, is related to interstitial lung disease and inclusion body myositis, and has symptoms including abnormality of the eye, muscle weakness and autoimmunity. An important gene associated with Dermatomyositis is IFIH1 (interferon induced with helicase C domain 1), and among its related pathways are Malaria and Thromboxane A2 receptor signaling. The drugs immunoglobulins, intravenous and potassium aminobenzoate and the compounds anticodon and tetramethylpyrazine have been mentioned in the context of this disorder. Affiliated tissues include muscle or, skin and lung.

Disease Ontology:9 A myositis that results in inflammation located in muscle or located in skin where a skin rash is often seen prior to the onset of muscle weakness. the disease may result from either a viral infection or an autoimmune reaction.

NINDS:42 Dermatomyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.

Wikipedia:63 Dermatomyositis (DM) is a connective-tissue disease related to polymyositis (PM) that is characterized... more...

Aliases & Classifications for Dermatomyositis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 42NINDS, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 33MeSH, 55SNOMED-CT, 27ICD9CM, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Dermatomyositis, Aliases & Descriptions:

Name: Dermatomyositis 9 41 42 11 43 47 60
Polymyositis with Skin Involvement 9
Dermatopolymyositis, Unspecified 9
 
Adult Type Dermatomyositis 60
Dermatopolymyositis 9
Dm 47


Classifications:



Characteristics (Orphanet epidemiological data):

47
dermatomyositis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe),1-9/1000000 (Australia),1-9/100000 (Australia),1-9/1000000 (Argentina),1-5/10000 (Argentina),1-9/1000000 (United States),1-9/1000000 (Spain); Age of onset: All ages; Age of death: any age


External Ids:

Disease Ontology9 DOID:10223
ICD9CM27 710.3
NCIt38 C26744
Orphanet47 221
MESH via Orphanet34 D003882
ICD10 via Orphanet26 M33.0, M33.1
UMLS via Orphanet61 C0011633
ICD1025 M33, M33.9

Related Diseases for Dermatomyositis

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Diseases in the Dermatomyositis family:

Adult Dermatomyositis

Diseases related to Dermatomyositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 294)
idRelated DiseaseScoreTop Affiliating Genes
1interstitial lung disease31.4HARS, SFTPD
2inclusion body myositis31.1ICAM1, VCAM1
3myositis30.8GARS, CHKB, ICAM1, VCAM1, HARS
4myopathy30.8CHKB, SDHB, GARS
5polymyositis30.6ICAM1, CCR7, VCAM1, SFTPD, HARS, CHKB
6dermatitis30.4HARS, ICAM1, VCAM1
7systemic lupus erythematosus30.3VCAM1, HLA-DQA1, ICAM1, CCR7
8melanoma30.2IFIH1, CCR7, ICAM1, CHKB, VCAM1
9oral lichen planus30.1VCAM1, ICAM1
10influenza29.9CCR7, IFIH1, SFTPD
11systemic scleroderma29.8SFTPD, VCAM1, ICAM1
12psoriasis29.8VCAM1, CCR7, ICAM1
13respiratory failure29.7SFTPD, ICAM1
14rheumatoid arthritis29.7SFTPD, CCR7, ICAM1, CHKB, VCAM1
15hiv-129.3SDHB, SFTPD, CCR7
16amyopathic dermatomyositis10.9
17adult dermatomyositis10.7
18calcinosis10.7
19childhood type dermatomyositis10.6
20lupus erythematosus10.6
21pneumonia10.6
22myotonic dystrophy10.5
23scleroderma10.5
24arthritis10.4
25panniculitis10.4
26breast cancer10.3
27adenocarcinoma10.3
28skin disease10.3
29lipodystrophy10.3
30arteriosclerosis obliterans10.2VCAM1, ICAM1
31henoch-schoenlein purpura10.2ICAM1, VCAM1
32rheumatoid vasculitis10.2ICAM1, VCAM1
33middle ear cholesteatoma10.2CHKB, ICAM1
34leukostasis10.2VCAM1, ICAM1
35nasopharyngeal carcinoma10.2
36pityriasis rubra pilaris10.2
37multicentric reticulohistiocytosis10.2
38nasopharyngitis10.2
39pneumatosis cystoides intestinalis10.2
40connective tissue disease10.2
41fasciitis10.2
42vernal keratoconjunctivitis10.2ICAM1, VCAM1
43mitochondrial disorders10.2SDHB, CHKB
44malaria10.2ICAM1, VCAM1
45diabetes insipidus10.2
46maturity-onset diabetes of the young10.2
47cutaneous lupus erythematosus10.2
48esophagitis10.2
49germ cell cancer10.2
50vasculitis10.2

Graphical network of the top 20 diseases related to Dermatomyositis:



Diseases related to dermatomyositis

Symptoms for Dermatomyositis

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Symptoms:

 47 (show all 50)
  • anomalies of eyelids, eyelashes and lacrimal system
  • palpebral edema/periorbital edema
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • cutaneous edema
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • abnormal emg/electromyogram/electropmyography
  • autoimmunity/autoimmune reaction/autoantibodies
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • dry/squaly skin/exfoliation
  • chronic skin infection/ulcerations/ulcers/cancrum
  • follicular/erythematous/edematous papules/milium
  • pruritus/itching
  • telangiectasic erythema/poikiloderma
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • nails anomalies
  • lung fibrosis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • repeat respiratory infections
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • hypotonia
  • articular/joint pain/arthralgia
  • arthritis/synovitis/synovial proliferation
  • periarticular tissue anomaly/extraarticular calcifications
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness
  • skin hypoplasia/aplasia/atrophy
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • skin photosensitivity
  • telangiectasiae of the skin
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • pulmonary hypertension
  • abnormal cry/voice/phonation disorder/nasal speech
  • myocardium anomalies/myocarditis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cardiac rhythm disorder/arrhythmia
  • angor pectoris/myocardial infarction
  • vascularitis/vasculitides/arteritis
  • gangrena/necrosis
  • elocution disorders/dysarthria/dysphonia
  • eosinophils anomalies/hypereosinophilia
  • neoplasms/tumors
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • gastrointestinal stromal tumor
  • lymphoma
  • fever/chilling

HPO human phenotypes related to Dermatomyositis:

(show all 43)
id Description Frequency HPO Source Accession
1 abnormality of the eye hallmark (90%) HP:0000478
2 muscle weakness hallmark (90%) HP:0001324
3 autoimmunity hallmark (90%) HP:0002960
4 myalgia hallmark (90%) HP:0003326
5 emg abnormality hallmark (90%) HP:0003457
6 periorbital edema hallmark (90%) HP:0100539
7 chondrocalcinosis typical (50%) HP:0000934
8 dry skin typical (50%) HP:0000958
9 pruritus typical (50%) HP:0000989
10 poikiloderma typical (50%) HP:0001029
11 acrocyanosis typical (50%) HP:0001063
12 muscular hypotonia typical (50%) HP:0001252
13 arthritis typical (50%) HP:0001369
14 abnormality of the nail typical (50%) HP:0001597
15 weight loss typical (50%) HP:0001824
16 restrictive lung disease typical (50%) HP:0002091
17 respiratory insufficiency typical (50%) HP:0002093
18 recurrent respiratory infections typical (50%) HP:0002205
19 pulmonary fibrosis typical (50%) HP:0002206
20 arthralgia typical (50%) HP:0002829
21 abnormal hair quantity typical (50%) HP:0011362
22 skin ulcer typical (50%) HP:0200042
23 cutaneous photosensitivity occasional (7.5%) HP:0000992
24 abnormality of the voice occasional (7.5%) HP:0001608
25 abnormality of the myocardium occasional (7.5%) HP:0001637
26 coronary artery disease occasional (7.5%) HP:0001677
27 abnormality of the pericardium occasional (7.5%) HP:0001697
28 abnormality of eosinophils occasional (7.5%) HP:0001879
29 pulmonary hypertension occasional (7.5%) HP:0002092
30 neurological speech impairment occasional (7.5%) HP:0002167
31 vasculitis occasional (7.5%) HP:0002633
32 lymphoma occasional (7.5%) HP:0002665
33 abnormality of temperature regulation occasional (7.5%) HP:0004370
34 aplasia/hypoplasia of the skin occasional (7.5%) HP:0008065
35 feeding difficulties in infancy occasional (7.5%) HP:0008872
36 arrhythmia occasional (7.5%) HP:0011675
37 neoplasm of the breast occasional (7.5%) HP:0100013
38 neoplasm of the lung occasional (7.5%) HP:0100526
39 teleangiectasia of the skin occasional (7.5%) HP:0100585
40 ovarian neoplasm occasional (7.5%) HP:0100615
41 cellulitis occasional (7.5%) HP:0100658
42 gastrointestinal stroma tumor occasional (7.5%) HP:0100723
43 gangrene occasional (7.5%) HP:0100758

Drugs & Therapeutics for Dermatomyositis

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Drug clinical trials:

Search ClinicalTrials for Dermatomyositis

Search NIH Clinical Center for Dermatomyositis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Dermatomyositis

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Anatomical Context for Dermatomyositis

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MalaCards organs/tissues related to Dermatomyositis:

31
Skin, Lung, Heart, Breast, T cells, Bone, Eye, Ovary, Testes, Thyroid, Monocytes, B cells, Endothelial, Skeletal muscle, Colon, Tongue, Brain, Liver, Prostate, Myeloid, Appendix

FMA organs/tissues related to Dermatomyositis:

14
Muscle or

Animal Models for Dermatomyositis or affiliated genes

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Publications for Dermatomyositis

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Articles related to Dermatomyositis:

(show top 50)    (show all 1084)
idTitleAuthorsYear
1
A case of sarcoidosis with interstitial lung disease mimicking clinically amyopathic dermatomyositis and rapidly progressive interstitial lung disease. (25431723)
2014
2
A case of dermatomyositis with esophageal fistula in whom blind mucosal biopsy detected occult oropharyngeal carcinoma. (25852538)
2014
3
Increased subsequent risk of acute coronary syndrome for patients with dermatomyositis/polymyositis: a nationwide population-based retrospective cohort study. (25205256)
2014
4
Anti-CADM-140/MDA5 autoantibody titer correlates with disease activity and predicts disease outcome in patients with dermatomyositis and rapidly progressive interstitial lung disease. (22644102)
2013
5
Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebo-phase trial. (23124935)
2013
6
Gemcitabine-induced radiation recall myositis in a patient with dermatomyositis. (24283707)
2013
7
Molecular profiling to diagnose a case of atypical dermatomyositis. (23732751)
2013
8
Low prevalence of anti-DFS70/LEDGF antibodies in patients with dermatomyositis and other systemic autoimmune rheumatic diseases. (23280167)
2013
9
Marked increase in serum KL-6 and surfactant proteinA D levels during the first 4A weeks after treatment predicts poor prognosis in patients with active interstitial pneumonia associated with polymyositis/dermatomyositis. (22983659)
2013
10
Mycophenolate mofetil therapy for rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis. (23615839)
2013
11
Hydroxyurea-induced dermatomyositis: true amyopathic dermatomyositis or dermatomyositis-like eruption? (22515579)
2012
12
Design of the muscles in motion study: a randomized controlled trial to evaluate the efficacy and feasibility of an individually tailored home-based exercise training program for children and adolescents with juvenile dermatomyositis. (22721424)
2012
13
Anti-TIF1I^ antibodies (anti-p155) in adult patients with dermatomyositis: comparison of different diagnostic assays. (22294626)
2012
14
Pneumomediastinum and massive subcutaneous emphysema associated with dermatomyositis. (23257541)
2012
15
Is dermatomyositis in patients with rheumatoid arthritis induced by anti-TNF-I+ therapy? (21221687)
2011
16
Oral manifestations as important symptoms for juvenile dermatomyositis early diagnosis: a case report. (20659183)
2011
17
Cytomegalovirus-associated gastric ulcers in a patient with dermatomyositis treated with steroid and cyclophosphamide pulse therapy. (21915824)
2011
18
Comparison of clinical features and drug therapies among European and Latin American patients with juvenile dermatomyositis. (21345298)
2011
19
The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody. (20015976)
2010
20
Reversed halo sign associated with dermatomyositis. (20686316)
2010
21
Juvenile-onset clinically amyopathic dermatomyositis: an overview of recent progress in diagnosis and management. (20034339)
2010
22
Destructive arthropathy associated with dermatomyositis sine myositis positive for anti-Jo-1 and anti-cyclic citrullinated peptide antibodies. (19738232)
2009
23
Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis. (18821695)
2008
24
Disease-specific quality indicators, outcome measures and guidelines in polymyositis and dermatomyositis. (18021522)
2007
25
Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis. (17469160)
2007
26
Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis. (17938031)
2007
27
Dermatomyositis, lobar panniculitis and inflammatory myopathy with abundant macrophages. (16809038)
2006
28
Genetically determined imbalance between serum levels of tumour necrosis factor (TNF) and interleukin (IL)-10 is associated with anti-Jo-1 and anti-Ro52 autoantibodies in patients with poly- and dermatomyositis. (16895750)
2006
29
Increased Fas and Bcl-2 expression on peripheral blood T and B lymphocytes from juvenile-onset systemic lupus erythematosus, but not from juvenile rheumatoid arthritis and juvenile dermatomyositis. (17162369)
2006
30
Identification of autoantibodies elicited in a patient with prostate cancer presenting as dermatomyositis. (16643611)
2006
31
Use of etanercept in the treatment of dermatomyositis: a case series. (16960940)
2006
32
Diagnostic significance of membrane attack complex and vitronectin in childhood dermatomyositis. (16159528)
2005
33
Intravenous cyclophosphamide pulse therapy in juvenile dermatomyositis. A review of efficacy and safety. (14722349)
2004
34
Update on juvenile dermatomyositis: new advances in understanding its etiopathogenesis. (12960487)
2003
35
Juvenile dermatomyositis associated with lipodystrophy. (17642934)
2003
36
Parathyroid hormone-related protein production by adenocarcinoma in Barrett's esophagus patient with dermatomyositis. (11478513)
2001
37
Amyopathic dermatomyositis in children: a diagnostic and therapeutic dilemma. (17039128)
2001
38
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)
2000
39
Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. (11055823)
2000
40
Dystrophic calcification in adult dermatomyositis: neuroimage. (11146618)
2000
41
Pneumatosis cystoides intestinalis in a patient with dermatomyositis. (10615280)
1999
42
Benefit of 6 months long-term physical training in polymyositis/dermatomyositis patients. (9973161)
1998
43
Germ cell cancer and dermatomyositis. (9543617)
1998
44
Low-dose methotrexate as an adjunctive therapy with surgery for ectropion complicating dermatomyositis. (8829501)
1996
45
Amyopathic dermatomyositis. (7492141)
1995
46
Hypertrichosis in juvenile dermatomyositis. (8034810)
1994
47
Relationship of cancer to inflammatory muscle diseases. Dermatomyositis, polymyositis, and inclusion body myositis. (7855330)
1994
48
Severe secondary amyloidosis in a dog with dermatomyositis. (2474585)
1989
49
Early ultrastructural alterations in adult dermatomyositis. Capillary abnormalities precede other structural changes in muscle. (2614466)
1989
50
Membranous glomerulonephritis, dermatomyositis, and bronchial carcinoma. (227526)
1979

Variations for Dermatomyositis

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Expression for genes affiliated with Dermatomyositis

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Search GEO for disease gene expression data for Dermatomyositis.

Pathways for genes affiliated with Dermatomyositis

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Compounds for genes affiliated with Dermatomyositis

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Compounds related to Dermatomyositis according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1anticodon4310.2KARS, GARS
2tetramethylpyrazine4310.1ICAM1, CHKB
3sodium cromoglycate4310.1ICAM1, VCAM1
4loratadine43 24 1212.1ICAM1, VCAM1
58 methoxypsoralen4310.1ICAM1, VCAM1
6aminoacyl-trna4310.0KARS, IARS, GARS
7sele4310.0VCAM1, ICAM1
8trna4310.0GARS, IARS, KARS
9helenalin4310.0ICAM1, VCAM1
10hcec4310.0VCAM1, ICAM1
11gliclazide43 49 1212.0VCAM1, ICAM1
12cuprophan4310.0ICAM1, VCAM1
13slex439.9VCAM1, ICAM1
14mycophenolic acid43 49 1211.9ICAM1, VCAM1
15apocynin43 5910.9ICAM1, VCAM1
16hydroxylysine439.9CHKB, SFTPD
17polymyxin b439.9VCAM1, ICAM1
18fluvastatin43 49 28 1212.8ICAM1, CHKB, VCAM1
19Adenosine monophosphate24 1210.8HARS, KARS, IARS, GARS
20phosphoric acid43 2410.8HARS, KARS, IARS, GARS
21pyrophosphate43 2410.8HARS, KARS, IARS, GARS
22pravastatin43 49 28 24 1213.8VCAM1, CHKB, ICAM1
23atorvastatin43 49 28 24 1213.7VCAM1, CHKB, ICAM1
24thenoyltrifluoroacetone43 1210.7SDHB, VCAM1
25okt3439.7ICAM1, VCAM1
26simvastatin43 49 59 28 24 1214.7VCAM1, CHKB, ICAM1
27beta-hydroxybutyrate439.7SDHB, CHKB
28groalpha439.6ICAM1, VCAM1
29triptolide439.5CCR7, ICAM1
30prednisolone43 28 1211.5SFTPD, VCAM1, CHKB
31budesonide43 49 1211.5ICAM1, VCAM1, SFTPD
32gssg439.5SDHB, CHKB
33Adenosine triphosphate24 1210.4HARS, KARS, CHKB, IARS, GARS
34rantes439.4VCAM1, ICAM1, CCR7
35leucine439.3SFTPD, KARS, CHKB, GARS
36matrigel439.2VCAM1, ICAM1, CCR7
37pge2439.2CCR7, ICAM1, CHKB, VCAM1
38endotoxin439.2SFTPD, VCAM1, CHKB, ICAM1
39polysaccharide439.1SFTPD, VCAM1, CHKB, ICAM1
40mannitol43 1210.0ICAM1, CHKB, VCAM1, SDHB
41norepinephrine43 24 1210.8SDHB, VCAM1, CHKB, CCR7
42aspartate438.8HLA-DQA1, SDHB, VCAM1, CHKB
43cholesterol43 28 24 1211.6CHKB, VCAM1, SDHB, SFTPD
44arginine438.6HLA-DQA1, KARS, SDHB, VCAM1, CHKB
45dexamethasone43 49 28 1211.4SFTPD, VCAM1, CHKB, ICAM1
46lactate438.3SFTPD, SDHB, VCAM1, CHKB, ICAM1
47alanine438.3KARS, SDHB, VCAM1, CHKB, CCR7, GARS
48oxygen43 249.3SFTPD, SDHB, VCAM1, CHKB, ICAM1
49cysteine438.2SFTPD, KARS, SDHB, VCAM1, CHKB, GARS
50calcium43 49 24 1210.7GARS, CCR7, CHKB, SDHB, KARS, SFTPD

GO Terms for genes affiliated with Dermatomyositis

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Cellular components related to Dermatomyositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9CCR7, ICAM1, VCAM1
2cytosolGO:00058298.7GARS, IFIH1, IARS, CHKB, KARS, HARS

Biological processes related to Dermatomyositis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1diadenosine tetraphosphate biosynthetic processGO:001596610.1GARS, KARS
2membrane to membrane dockingGO:00226149.9VCAM1, ICAM1
3leukocyte cell-cell adhesionGO:00071599.8ICAM1, VCAM1
4heterophilic cell-cell adhesionGO:00071579.8VCAM1, ICAM1
5response to ionizing radiationGO:00102129.7ICAM1, VCAM1
6cellular response to glucose stimulusGO:00713339.6ICAM1, VCAM1
7tRNA aminoacylation for protein translationGO:00064189.6GARS, IARS, KARS, HARS
8interferon-gamma-mediated signaling pathwayGO:00603339.4HLA-DQA1, VCAM1, ICAM1
9gene expressionGO:00104679.3HARS, KARS, IARS, GARS
10cytokine-mediated signaling pathwayGO:00192219.3ICAM1, VCAM1, HLA-DQA1
11positive regulation of actin filament polymerizationGO:00308389.2CCR7, ICAM1

Molecular functions related to Dermatomyositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1helicase activityGO:000438610.0IFIH1, CHD3
2ATP bindingGO:00055248.2GARS, IFIH1, IARS, CHD3, CHKB, KARS

Products for genes affiliated with Dermatomyositis

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Sources for Dermatomyositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet