DM
MCID: DRM010
MIFTS: 59

Dermatomyositis (DM) malady

Neuronal, Nephrological, Bone, Skin categories

Summaries for Dermatomyositis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Dermatomyositis is one of a group of acquired muscle diseases called inflammatory myopathies (disorder of muscle tissue or muscles), which are characterized by chronic muscle inflammation accompanied by muscle weakness. the cardinal symptom is a skin rash that precedes or accompanies progressive muscle weakness. dermatomyositis may occur at any age, but is most common in adults in their late 40s to early 60s, or children between 5 and 15 years of age. there is no cure for dermatomyositis, but the symptoms can be treated. options include medication, physical therapy, exercise, heat therapy (including microwave and ultrasound), orthotics and assistive devices, and rest. the cause of dermatomyositis is unknown. last updated: 8/26/2013

MalaCards: Dermatomyositis, also known as polymyositis with skin involvement, is related to polymyositis and adult dermatomyositis, and has symptoms including feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia, elocution disorders/dysarthria/dysphonia and respiratory distress/dyspnea/respiratory failure/lung volume reduction. An important gene associated with Dermatomyositis is IFIH1 (interferon induced with helicase C domain 1), and among its related pathways are Immune System and Interferon Signaling. The compounds pyrophosphate and Adenosine triphosphate have been mentioned in the context of this disorder. Affiliated tissues include muscle or.

Disease Ontology:8 A myositis that results in inflammation located in muscle or located in skin where a skin rash is often seen prior to the onset of muscle weakness. the disease may result from either a viral infection or an autoimmune reaction.

NINDS:44 Dermatomyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.

Wikipedia:64 Dermatomyositis (DM) is a connective-tissue disease related to polymyositis (PM) that is characterized... more...

Aliases & Classifications for Dermatomyositis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Nephrological, Bone, Skin


Characteristics (Orphanet epidemiological data):

49
dermatomyositis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

dermatomyositis 8 43 44 10 45 49
polymyositis with skin involvement 8
dermatopolymyositis, unspecified 8
adult-onset dermatomyositis 49
adult type dermatomyositis 61
dermatopolymyositis 8
dm 49


External Ids:

Disease Ontology8 DOID:10223
NCIt40 C26744
ICD9CM27 710.3
SNOMED-CT via Orphanet58 396230008
UMLS via Orphanet62 C0011633
MESH via Orphanet36 D003882
ICD10 via Orphanet26 M33.0, M33.1
ICD1025 M33, M33.9

Related Diseases for Dermatomyositis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Dermatomyositis family:

adult dermatomyositis

Diseases related to Dermatomyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1polymyositis31.5CCR7, SFTPD, ICAM1, HARS, VCAM1, CHKB
2adult dermatomyositis31.2UBA2, IFIT3
3inclusion body myositis30.7VCAM1, ICAM1
4systemic lupus erythematosus30.7VCAM1, HLA-DQA1, ICAM1, CCR7
5arthritis30.6CCR7, ICAM1
6tuberculosis30.1SFTPD, CCR7
7celiac disease29.8HLA-DQA1, HLA-DQA2
8amyopathic dermatomyositis10.9
9childhood type dermatomyositis10.4
10systemic scleroderma10.3
11congenital myotonic dystrophy10.3
12adenocarcinoma10.2
13multicentric reticulohistiocytosis10.2
14pneumatosis cystoides intestinalis10.2
15testicular cancer10.2
16rheumatic disease10.2
17pityriasis rubra pilaris10.2
18bladder carcinoma10.2
19vasculitis10.2
20germ cell cancer10.2
21diabetes insipidus10.2
22acute interstitial pneumonia10.1
23cutaneous lupus erythematosus10.1
24pemphigus10.1
25arthropathy10.1
26thymic carcinoma10.1
27vaccinia10.1
28maturity-onset diabetes of the young10.1
29monogenic diabetes10.1
30hemophagocytic lymphohistiocytosis10.1
31mixed connective tissue disease10.1
32juvenile rheumatoid arthritis10.1
33acute leukemia10.1
34antisynthetase syndrome10.1
35pulmonary function10.1
36myositis10.0VCAM1, CHKB, PIK3C2A, GARS, HARS, ICAM1
37asthma10.0CCR7, SFTPD, ICAM1, HLA-DQA1, CHKB, VCAM1
38dermatitis10.0VCAM1, PIK3C2A, HARS, ICAM1
39rheumatoid arthritis10.0VCAM1, CHKB, ICAM1, SFTPD, CCR7
40influenza10.0CCR7, SFTPD, IFIH1
41pneumonia10.0PIK3C2A, ICAM1, SFTPD
42psoriasis10.0CCR7, ICAM1, VCAM1
43coronary artery disease,10.0VCAM1, CHKB, PIK3C2A, ICAM1
44graves' disease10.0ICAM1, HLA-DQA1, VCAM1
45myopathy10.0GARS, PIK3C2A, CHKB
46interstitial lung disease10.0SFTPD, HARS
47sarcoidosis10.0ICAM1, SFTPD
48connective tissue disease10.0ICAM1, VCAM1
49allergic rhinitis10.0ICAM1, VCAM1
50rhinitis10.0VCAM1, ICAM1

Graphical network of the top 20 diseases related to Dermatomyositis:



Diseases related to dermatomyositis

Clinical Features for Dermatomyositis

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 50)
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • elocution disorders/dysarthria/dysphonia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • hypotonia
  • muscle weakness/flaccidity
  • repeat respiratory infections
  • arthritis/synovitis/synovial proliferation
  • asthenia/fatigue/weakness
  • fever/chilling
  • articular/joint pain/arthralgia
  • abnormal cry/voice/phonation disorder/nasal speech
  • lung fibrosis
  • nails anomalies
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • abnormal emg/electromyogram/electropmyography
  • cardiac rhythm disorder/arrhythmia
  • dry/squaly skin/exfoliation
  • chronic skin infection/ulcerations/ulcers/cancrum
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • follicular/erythematous/edematous papules/milium
  • pruritus/itching
  • cutaneous edema
  • telangiectasiae of the skin
  • skin photosensitivity
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • cough
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • gangrena/necrosis
  • myalgia/muscular pain
  • autoimmunity/autoimmune reaction/autoantibodies
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • angor pectoris/myocardial infarction
  • periarticular tissue anomaly/extraarticular calcifications
  • pulmonary hypertension
  • myocardium anomalies/myocarditis
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • anomalies of eyelids, eyelashes and lacrimal system
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • neoplasms/tumors
  • skin hypoplasia/aplasia/atrophy
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • vascularitis/vasculitides/arteritis
  • lymphoma
  • palpebral edema/periorbital edema
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • eosinophils anomalies/hypereosinophilia
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • telangiectasic erythema/poikiloderma
  • gastrointestinal stromal tumor

Drugs & Therapeutics for Dermatomyositis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Dermatomyositis

Drug clinical trials:

Search ClinicalTrials for Dermatomyositis

Search NIH Clinical Center for Dermatomyositis

Search CenterWatch for Dermatomyositis

Genetic Tests for Dermatomyositis

Anatomical Context for Dermatomyositis

Sources:
14FMA
See all sources

FMA organs/tissues related to Dermatomyositis:

14
Muscle or

Animal Models for Dermatomyositis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Dermatomyositis

Sources:
51PubMed
See all sources

Articles related to Dermatomyositis:

(show top 50)    (show all 1018)
idTitleAuthorsYear
1
Juvenile dermatomyositis in South African children is characterised by frequent dystropic calcification: a cross sectional study. (24397895)
2014
2
Unrecognized juvenile dermatomyositis complicated by calcinosis universalis: a case report from Cameroon. (24401174)
2014
3
Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebo-phase trial. (23124935)
2013
4
Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis: comparison with a UK Caucasian cohort. (22843487)
2013
5
Serum miR-21 levels in patients with dermatomyositis. (23137528)
2013
6
Whole microvascular unit deletions in dermatomyositis. (22962315)
2013
7
Limitations to the 6-minute walk test in dermatomyositis with interstitial lung disease in comparison with idiopathic interstitial pneumonia. (23400027)
2013
8
Successful combination therapy with corticosteroids, biweekly intravenous pulse cyclophosphamide and cyclosporin A for acute interstitial pneumonia in patients with dermatomyositis : report of three cases. (23629432)
2013
9
A rare paraneoplastic dermatomyositis in bladder cancer with fatal outcome. (23504689)
2013
10
Dermatomyositis is associated with an increased risk of cardiovascular and cerebrovascular events: a Taiwanese population-based longitudinal follow-up study. (23330740)
2013
11
Hydroxyurea-induced dermatomyositis: true amyopathic dermatomyositis or dermatomyositis-like eruption? (22515579)
2012
12
Polymyositis and dermatomyositis in Sarawak: a profile of patients treated in the Sarawak General Hospital. (21243497)
2012
13
Response of mucocutaneous lesions to rituximab in a case of melanoma differentiation antigen 5-related dermatomyositis. (23428928)
2012
14
Association of tumor necrosis factor I+ (TNF-I+) and interleukin 10 (IL-10) gene polymorphisms in dermatomyositis patients: a pilot study. (23069299)
2012
15
Clinical features of anti-TIF1-I+ antibody-positive dermatomyositis patients are closely associated with coexistent dermatomyositis-specific autoantibodies and anti-TIF1-I^ or anti-Mi-2 autoantibodies. (22539482)
2012
16
Exercise training in juvenile dermatomyositis. (22505288)
2012
17
Inverse Gottron's papules: an unusual cutaneous manifestation of juvenile dermatomyositis. (22211376)
2012
18
A national registry for juvenile dermatomyositis and other paediatric idiopathic inflammatory myopathies: 10 years' experience; the Juvenile Dermatomyositis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies. (20823094)
2011
19
Juvenile dermatomyositis: immunopathogenesis, role of myositis-specific autoantibodies, and review of rituximab use. (21793879)
2011
20
Therapeutic drug monitoring of cyclosporine microemulsion in interstitial pneumonia with dermatomyositis. (20680374)
2011
21
Fulminant dermatomyositis with flagellate erythema. (21818513)
2011
22
Erythema elevatum diutinum associated with dermatomyositis. (21496713)
2011
23
Nailfold capillary density is importantly associated over time with muscle and skin disease activity in juvenile dermatomyositis. (21156669)
2011
24
Increased serum concentration of immune cell derived microparticles in polymyositis/dermatomyositis. (20043950)
2010
25
Dermatomyositis and polymyositis: Clinical presentation, autoantibodies, and pathogenesis. (20146695)
2010
26
Association of anti-glomerular basement membrane antibody disease with dermatomyositis and psoriasis: case report. (21181073)
2010
27
Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy. (20186858)
2010
28
Juvenile dermatomyositis with tongue calcinosis and poor growth. (21030377)
2010
29
T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cells. (19752224)
2009
30
Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis. (19479859)
2009
31
Bone mineral apparent density in juvenile dermatomyositis: the role of lean body mass and glucocorticoid use. (18189194)
2008
32
Predicting factors of interstitial lung disease in dermatomyositis and polymyositis. (17225013)
2007
33
Effect of physical training on the proportion of slow-twitch type I muscle fibers, a novel nonimmune-mediated mechanism for muscle impairment in polymyositis or dermatomyositis. (17907213)
2007
34
Immunopathological changes of micro-vessels in dermatomyositis]. (17064530)
2006
35
Ureteral calcinosis in juvenile dermatomyositis: successful precocious surgical management. (17081329)
2006
36
Electric shock wave lithotripsy (ESWL) as a pain control measure in dermatomyositis with calcinosis cutis-old method, new discovery. (15565396)
2005
37
A close look at autoimmune muscle disorders: association of Lambert-Eaton myasthenic syndrome with dermatomyositis. (15370725)
2004
38
Treatment of dermatomyositis and polymyositis with anti-tumor necrosis factor-alpha: long-term follow-up. (15240986)
2004
39
Infections in systemic connective tissue diseases: systemic lupus erythematosus, scleroderma, and polymyositis/dermatomyositis. (12635506)
2003
40
A causal role for parvovirus B19 infection in adult dermatomyositis and other autoimmune syndromes. (11100810)
2000
41
Adult dermatomyositis with livedo reticularis and multiple skin ulcers. (9731966)
1998
42
Malignancy in adult dermatomyositis. (9466195)
1997
43
Case Report: amyopathic dermatomyositis associated with transformed malignant lymphoma. (8615400)
1996
44
Amyopathic dermatomyositis. (7492141)
1995
45
An update on juvenile dermatomyositis. (8519618)
1995
46
A case of adult dermatomyositis treated with cyclosporin A. (1458294)
1992
47
Streptococcus pyomyositis occurring in a patient with dermatomyositis in a country with temperate climate. (1404172)
1992
48
Amyopathic dermatomyositis (dermatomyositis sinAc myositis). Presentation of six new cases and review of the literature. (1869684)
1991
49
Polymyositis/dermatomyositis associated with dermatitis herpetiformis. (2789048)
1989
50
Jaccoud's arthropathy in adult dermatomyositis. (3533342)
1986

Genetic Variations for Dermatomyositis

Expression for genes affiliated with Dermatomyositis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dermatomyositis

Search GEO for disease gene expression data for Dermatomyositis.

Pathways for genes affiliated with Dermatomyositis

Sources:
54Reactome, 30KEGG, 52QIAGEN
See all sources

Compounds for genes affiliated with Dermatomyositis

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Dermatomyositis according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1pyrophosphate45 2412.2CMAS, UBA2, KARS, HARS, GARS, PIK3C2A
2Adenosine triphosphate11 2412.2UBA2, KARS, HARS, GARS, PIK3C2A, CHKB
3phosphoric acid45 2412.2UBA2, KARS, HARS, GARS, IARS, CMAS
4Adenosine monophosphate11 2412.1UBA2, KARS, HARS, GARS, IARS
5polysaccharide4511.1SFTPD, ICAM1, CHKB, CMAS, VCAM1
6fluvastatin45 50 29 1114.1ICAM1, PIK3C2A, CHKB, VCAM1
7pravastatin45 50 29 11 2415.1VCAM1, CHKB, PIK3C2A, ICAM1
8alanine4511.0CCR7, KARS, GARS, PIK3C2A, CHKB, VCAM1
9atorvastatin45 50 29 11 2415.0VCAM1, CHKB, PIK3C2A, ICAM1
10prednisolone45 29 1113.0VCAM1, CHKB, PIK3C2A, SFTPD
11simvastatin45 50 60 29 11 2416.0ICAM1, PIK3C2A, CHKB, VCAM1
12lactate4511.0SFTPD, ICAM1, PIK3C2A, CHKB, VCAM1
13endotoxin4511.0SFTPD, ICAM1, CHKB, VCAM1
14aminoacyl-trna4511.0KARS, GARS, IARS
15budesonide45 50 1113.0SFTPD, ICAM1, VCAM1
16cerivastatin45 50 29 1114.0CHKB, PIK3C2A, ICAM1
17trna4510.9IARS, GARS, KARS
18fenofibrate45 50 1112.9VCAM1, PIK3C2A, ICAM1
19alpha-hydroxybutyrate4510.9PIK3C2A, CHKB
20thallium4510.9PIK3C2A, CHKB
21fibrinogen4510.9ICAM1, PIK3C2A, CHKB, VCAM1
22tetramethylpyrazine4510.8CHKB, ICAM1
23hydroxylysine4510.8SFTPD, CHKB
24sodium cromoglycate4510.8VCAM1, ICAM1
25dantrolene45 29 1112.8CHKB, PIK3C2A
26succinylcholine45 29 1112.7CHKB, PIK3C2A
278 methoxypsoralen4510.7VCAM1, ICAM1
28loratadine45 11 2412.6VCAM1, ICAM1
29anticodon4510.6GARS, KARS
30norepinephrine45 11 2412.6CCR7, CHKB
31gamma-hydroxybutyrate4510.5CHKB, PIK3C2A
32sele4510.3VCAM1, ICAM1

GO Terms for genes affiliated with Dermatomyositis

Sources:
16Gene Ontology
See all sources

Cellular components related to Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.9IFIT3, IFIH1, UBA2, KARS, HARS, GARS
2cytosolGO:00582910.9IFIT3, IFIH1, KARS, HARS, GARS, PIK3C2A
3ER to Golgi transport vesicle membraneGO:01250710.7STX17, HLA-DQA1, HLA-DQA2
4NuRD complexGO:01658110.6CHD4, CHD3
5MHC class II protein complexGO:04261310.3HLA-DQA1, HLA-DQA2

Biological processes related to Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tRNA aminoacylation for protein translationGO:00641810.8IARS, GARS, HARS, KARS
2interferon-gamma-mediated signaling pathwayGO:06033310.7ICAM1, HLA-DQA2, HLA-DQA1, VCAM1
3cytokine-mediated signaling pathwayGO:01922110.7IFIT3, ICAM1, HLA-DQA2, HLA-DQA1, VCAM1
4modulation by virus of host morphology or physiologyGO:01904810.7VCAM1, KARS, ICAM1, IFIH1
5diadenosine tetraphosphate biosynthetic processGO:01596610.5GARS, KARS
6membrane to membrane dockingGO:02261410.3ICAM1, VCAM1

Molecular functions related to Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00552410.7IARS, IFIH1, UBA2, KARS, HARS, GARS
2MHC class II receptor activityGO:03239510.6HLA-DQA1, HLA-DQA2

Products for genes affiliated with Dermatomyositis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dermatomyositis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet