Categories: Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Skin diseases, Muscle diseases
Aliases & Descriptions for Dermatomyositis:
Orphanet epidemiological data:52
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe),1-9/1000000 (Australia),1-9/100000 (Australia),1-9/1000000 (Argentina),1-5/10000 (Argentina),1-9/1000000 (United States),1-9/1000000 (Spain); Age of onset: All ages; Age of death: any age
Global: Rare diseases
Anatomical: Neuronal diseases, Nephrological diseases, Bone diseases, Skin diseases, Muscle diseases
ICD10: 29 28
Rare neurological diseases
Rare renal diseases
Rare systemic and rhumatological diseases
Rare skin diseases
NIH Rare Diseases:46 Amyopathic dermatomyositis is a form of dermatomyositis characterized by the presence of typical skin findings without muscle weakness. some of the skin changes that suggest dermatomyositis include a pink rash on the face, neck, forearms and upper chest; gottron's papules and heliotrope eyelids. pruritis and photosensitivity are common, as is scalp inflammation and thinning of the hair. while patients with amyopathic dermatomyositis should not have clinically evident muscle weakness, minor muscle abnormalities may be included. fatigue is reported in at least 50% of patients. some cases have been associated with internal malignancy and/or interstitial lung disease. treatment may include sun avoidance, ample use of sunscreen, topical corticosteroids, antimalarial agents, methotrexate, mycophenolate mofetil, or intravenous (iv) immunoglobulin. last updated: 1/10/2013
MalaCards based summary: Dermatomyositis, also known as amyopathic dermatomyositis, is related to hemophagocytic lymphohistiocytosis and hypertrichosis, and has symptoms including abnormality of the eye, muscle weakness and autoimmunity. An important gene associated with Dermatomyositis is IFIH1 (Interferon Induced With Helicase C Domain 1), and among its related pathways are Signaling events mediated by HDAC Class I and Amoebiasis. The drugs immunoglobulins, intravenous and potassium aminobenzoate have been mentioned in the context of this disorder. Affiliated tissues include muscle or, skin and lung.
Disease Ontology:11 A myositis that results in inflammation located in muscle or located in skin where a skin rash is often seen prior to the onset of muscle weakness. the disease may result from either a viral infection or an autoimmune reaction.
NINDS:47 Dermatomyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.
Wikipedia:69 Dermatomyositis (DM) is a connective-tissue disease related to polymyositis (PM) that is characterized... more...
Symptoms:52 (show all 49)
HPO human phenotypes related to Dermatomyositis:(show all 43)
UMLS symptoms related to Dermatomyositis:exanthema, pruritus, skin manifestations
Drugs for Dermatomyositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show all 34)
Interventional clinical trials:(show top 50) (show all 67)
Search NIH Clinical Center for Dermatomyositis
Inferred drug relations via UMLS66/NDF-RT44:
MalaCards organs/tissues related to Dermatomyositis:34
Skin, Lung, Heart, Breast, T cells, Bone, Testes
FMA organs/tissues related to Dermatomyositis:17
Articles related to Dermatomyositis:(show top 50) (show all 1227)
Search GEO for disease gene expression data for Dermatomyositis.
Pathways related to Dermatomyositis according to GeneCards Suite gene sharing:(show all 15)
Biological processes related to Dermatomyositis according to GeneCards Suite gene sharing:(show all 8)
Molecular functions related to Dermatomyositis according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet