DM
MCID: DRM010
MIFTS: 70

Dermatomyositis (DM) malady

Neuronal diseases, Nephrological diseases, Bone diseases, Skin diseases categories

Summaries for Dermatomyositis

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Dermatomyositis is one of a group of acquired muscle diseases called inflammatory myopathies (disorder of muscle tissue or muscles), which are characterized by chronic muscle inflammation accompanied by muscle weakness. the cardinal symptom is a skin rash that precedes or accompanies progressive muscle weakness. dermatomyositis may occur at any age, but is most common in adults in their late 40s to early 60s, or children between 5 and 15 years of age. there is no cure for dermatomyositis, but the symptoms can be treated. options include medication, physical therapy, exercise, heat therapy (including microwave and ultrasound), orthotics and assistive devices, and rest. the cause of dermatomyositis is unknown. last updated: 8/26/2013

MalaCards: Dermatomyositis, also known as polymyositis with skin involvement, is related to adult dermatomyositis and interstitial lung disease, and has symptoms including cardiac rhythm disorder/arrhythmia, angor pectoris/myocardial infarction and vascularitis/vasculitides/arteritis. An important gene associated with Dermatomyositis is IFIH1 (interferon induced with helicase C domain 1), and among its related pathways are Immune System and Interferon Signaling. The compounds pyrophosphate and Adenosine triphosphate have been mentioned in the context of this disorder. Affiliated tissues include muscle or, skin and lung.

Disease Ontology:8 A myositis that results in inflammation located in muscle or located in skin where a skin rash is often seen prior to the onset of muscle weakness. the disease may result from either a viral infection or an autoimmune reaction.

NINDS:43 Dermatomyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.

Wikipedia:63 Dermatomyositis (DM) is a connective-tissue disease related to polymyositis (PM) that is characterized... more...

Description from OMIM:46 160750

Aliases & Classifications for Dermatomyositis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

48
dermatomyositis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

dermatomyositis 8 42 43 10 44 48 46
polymyositis with skin involvement 8
dermatopolymyositis, unspecified 8
adult-onset dermatomyositis 48
adult type dermatomyositis 60
dermatopolymyositis 8
dm 48


External Ids:

Disease Ontology8 DOID:10223
NCIt39 C26744
ICD9CM27 710.3
SNOMED-CT via Orphanet57 396230008, 402425006, 396229003
UMLS via Orphanet61 C0011633
MESH via Orphanet35 D003882
ICD10 via Orphanet26 M33.0, M33.1
OMIM46 160750
ICD1025 M33, M33.9

Related Diseases for Dermatomyositis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Dermatomyositis family:

Adult Dermatomyositis

Diseases related to Dermatomyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 273)
idRelated DiseaseScoreTop Affiliating Genes
1adult dermatomyositis31.2IFIT3, UBA2
2interstitial lung disease31.1SFTPD, HARS
3myositis31.0ICAM1, HARS, PIK3C2A, CHKB, VCAM1, GARS
4pneumonia30.7PIK3C2A, ICAM1, SFTPD
5inclusion body myositis30.7VCAM1, ICAM1
6myopathy30.6PIK3C2A, CHKB, GARS
7systemic lupus erythematosus30.6ICAM1, VCAM1, CCR7, HLA-DQA1
8diabetes mellitus30.6IFIH1, ICAM1, HLA-DQA2, HLA-DQA1, PIK3C2A, VCAM1
9arthritis30.6ICAM1, CCR7
10melanoma30.5IFIH1, CCR7, ICAM1, CHKB, VCAM1
11rheumatoid arthritis30.4SFTPD, ICAM1, CHKB, CCR7, VCAM1
12connective tissue disease30.2VCAM1, ICAM1
13dermatitis30.0HARS, ICAM1, PIK3C2A, VCAM1
14influenza30.0CCR7, IFIH1, SFTPD
15psoriasis30.0VCAM1, ICAM1, CCR7
16tuberculosis30.0CCR7, SFTPD
17celiac disease29.8HLA-DQA1, HLA-DQA2
18polymyositis29.7ICAM1, CCR7, SFTPD, HARS, PIK3C2A, CHKB
19sarcoidosis29.6SFTPD, ICAM1
20respiratory failure29.6SFTPD, ICAM1, PIK3C2A
21calcinosis10.7
22lupus erythematosus10.5
23myotonic dystrophy10.4
24childhood type dermatomyositis10.4
25scleroderma10.4
26skin disease10.4
27panniculitis10.3
28amyopathic dermatomyositis10.3
29breast cancer10.2
30systemic scleroderma10.2
31adenocarcinoma10.2
32maturity-onset diabetes of the young10.2
33multicentric reticulohistiocytosis10.2
34pneumatosis cystoides intestinalis10.2
35fasciitis10.2
36lipodystrophy10.2
37testicular cancer10.2
38pityriasis rubra pilaris10.1
39nasopharyngitis10.1
40bladder carcinoma10.1
41vasculitis10.1
42diabetes insipidus10.1
43acute interstitial pneumonia10.1
44cutaneous lupus erythematosus10.1
45pemphigus10.1
46arthropathy10.1
47esophagitis10.1
48glomerulonephritis10.1
49hypertrichosis10.1
50lung cancer10.1

Graphical network of the top 20 diseases related to Dermatomyositis:



Diseases related to dermatomyositis

Clinical Features for Dermatomyositis

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

160750

Symptoms:

48 (show all 50)
  • cardiac rhythm disorder/arrhythmia
  • angor pectoris/myocardial infarction
  • vascularitis/vasculitides/arteritis
  • gangrena/necrosis
  • elocution disorders/dysarthria/dysphonia
  • eosinophils anomalies/hypereosinophilia
  • neoplasms/tumors
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • gastrointestinal stromal tumor
  • lymphoma
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • myocardium anomalies/myocarditis
  • lung fibrosis
  • nails anomalies
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • telangiectasic erythema/poikiloderma
  • pruritus/itching
  • follicular/erythematous/edematous papules/milium
  • chronic skin infection/ulcerations/ulcers/cancrum
  • dry/squaly skin/exfoliation
  • autoimmunity/autoimmune reaction/autoantibodies
  • abnormal emg/electromyogram/electropmyography
  • myalgia/muscular pain
  • muscle weakness/flaccidity
  • cutaneous edema
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • palpebral edema/periorbital edema
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • abnormal cry/voice/phonation disorder/nasal speech
  • pulmonary hypertension
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • telangiectasiae of the skin
  • skin photosensitivity
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • skin hypoplasia/aplasia/atrophy
  • asthenia/fatigue/weakness
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • periarticular tissue anomaly/extraarticular calcifications
  • arthritis/synovitis/synovial proliferation
  • articular/joint pain/arthralgia
  • hypotonia
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • repeat respiratory infections
  • anomalies of eyelids, eyelashes and lacrimal system

Drugs & Therapeutics for Dermatomyositis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dermatomyositis

Drug clinical trials:

Search ClinicalTrials for Dermatomyositis

Search NIH Clinical Center for Dermatomyositis

Search CenterWatch for Dermatomyositis

Genetic Tests for Dermatomyositis

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Anatomical Context for Dermatomyositis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Dermatomyositis:

32
Skin, Lung, Heart, Breast, T cells, Bone, Ovary, Testes, Thyroid, Monocytes, B cells, Endothelial, Tongue, Colon, Skeletal muscle, Prostate, Appendix, Brain, Liver, Myeloid

FMA organs/tissues related to Dermatomyositis:

14
Muscle or

Animal Models for Dermatomyositis or affiliated genes

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Publications for Dermatomyositis

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Sources:
50PubMed
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Articles related to Dermatomyositis:

(show top 50)    (show all 1016)
idTitleAuthorsYear
1
The Evolving Spectrum of Polymyositis and Dermatomyositis-Moving Towards Clinicoserological Syndromes: A Critical Review. (24048686)
2013
2
Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara. (23557279)
2013
3
Dermatomyositis as presenting feature of ovarian cancer, treated with neo-adjuvant chemotherapy and interval debulking surgery. (24371708)
2013
4
Intravenous immunoglobulin for refractory cutaneous dermatomyositis: a retrospective analysis from an academic medical center. (24034377)
2013
5
Hyperimmunoglobulin E syndrome with juvenile dermatomyositis and calcinosis. (20373123)
2013
6
The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis. (22281496)
2012
7
Dermatomyositis associated with generalized subcutaneous edema and Evans syndrome. (22030016)
2012
8
Anti-tumor necrosis factor inhibitor therapy-induced dermatomyositis and fasciitis. (22210682)
2012
9
Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. (22546500)
2012
10
Dermatomyositis sine myositis with membranoproliferative glomerulonephritis. (22937456)
2012
11
Two young-adult female cases of dermatomyositis with antibodies for transcriptional intermediary factor 1-I^. (22992252)
2012
12
Characterization of dermatomyositis with coexistence of anti-Jo-1 and anti-SRP antibodies. (22466843)
2012
13
Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis. (22244459)
2012
14
The co-existence of vulvar lichen sclerosus, ulcerated calcinosis cutis, and dermatomyositis: coincidence or immunological mechanism? (22346282)
2011
15
Malignant peripheral nerve sheath tumor in a patient with juvenile-onset dermatomyositis. (21441814)
2011
16
Dermatomyositis presenting as a paraneoplastic syndrome due to underlying breast cancer. (22714621)
2011
17
Infectious complications in polymyositis and dermatomyositis: a series of 279 patients. (21047670)
2011
18
Resistant dermatomyositis complicated by tubercular myositis and successfully treated with rituximab. (21483146)
2011
19
Responsiveness to exercise training in juvenile dermatomyositis: a twin case study. (21106107)
2010
20
Interstitial lung disease in classic and skin-predominant dermatomyositis: a retrospective study with screening recommendations. (20644033)
2010
21
Successful treatment with tacrolimus of progressive interstitial pneumonia associated with amyopathic dermatomyositis refractory to cyclosporine. (20130943)
2010
22
Paraneoplastic dermatomyositis associated with testicular cancer: a case report and literature review. (20372774)
2010
23
Amyopathic dermatomyositis or dermatomyositis-like skin disease: retrospective review of 16 cases with amyopathic dermatomyositis. (19294477)
2009
24
Massive gluteal calcinosis in a 10-year-old girl with juvenile dermatomyositis: successful surgical management. (19952619)
2009
25
Re: Wu JJ, Metz BJ. Calcinosis cutis of juvenile dermatomyositis treated with incision and drainage. (19215275)
2009
26
Fine-needle aspiration biopsy cytology of cutaneous calcinosis in a 74-year-old woman with dermatomyositis on methotrexate therapy: a case report. (18702364)
2008
27
Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis. (18671865)
2008
28
Undescribed case of necrotic ulcerative amyopathic dermatomyositis in bone metastatic breast cancer. (19000050)
2008
29
Effectiveness of infliximab in the treatment of refractory juvenile dermatomyositis with calcinosis. (18403404)
2008
30
Diffusion-weighted imaging of inflammatory myopathies: polymyositis and dermatomyositis. (18022843)
2008
31
Rapidly progressive interstitial pneumonia associated with clinically amyopathic dermatomyositis successfully treated with polymyxin B-immobilized fiber column hemoperfusion. (18421199)
2008
32
Successful resection of dermatomyositis associated with thymic carcinoma: report of a case. (18306999)
2008
33
HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap. (18003662)
2007
34
Staphylococcus aureus panniculitis complicating juvenile dermatomyositis. (17261618)
2007
35
Established and new treatments of the idiopathic inflammatory myopathies: dermatomyositis and polymyositis. (18173928)
2007
36
Use of etanercept in the treatment of dermatomyositis: a case series. (16960940)
2006
37
Therapeutic options in autoimmune inflammatory myopathies (dermatomyositis, polymyositis, inclusion body myositis). (16998756)
2006
38
Severe gastrointestinal inflammation in adult dermatomyositis: characterization of a novel clinical association. (17170621)
2006
39
Opportunistic infections in polymyositis and dermatomyositis. (15818648)
2005
40
Preservation of in vitro muscle fiber function in dermatomyositis and inclusion body myositis: a single fiber study. (15833427)
2005
41
Intravenous cyclophosphamide pulse therapy in juvenile dermatomyositis. A review of efficacy and safety. (14722349)
2004
42
Immunolocalization of protectin (CD59) and macrophages in polymyositis and dermatomyositis. (15020079)
2004
43
Nonspecific interstitial pneumonia with poor prognosis associated with amyopathic dermatomyositis. (15497521)
2004
44
HLA class II haplotypes associated with pulmonary interstitial lesions of polymyositis/dermatomyositis in Japanese patients. (11972875)
2002
45
Severe dermatomyositis with rhabdomyolysis and paralytic ileus: a case successfully treated with plasmapheresis and intravenous immunoglobulin. (12453096)
2002
46
Cardiac troponin and beta-type myosin heavy chain concentrations in patients with polymyositis or dermatomyositis. (11282091)
2001
47
Juvenile amyopathic dermatomyositis: results of a case finding descriptive survey. (10955348)
2000
48
Possible involvement of tumour-derived interleukin-6 in dermatomyositis associated with cervical squamous cell carcinoma. (9115948)
1997
49
Elevated serum levels of interleukin-1 receptor antagonist in polymyositis/dermatomyositis. A biologic marker of disease activity with a possible role in the lack of acute-phase protein response. (7986220)
1994
50
Endomyocardial fibrosis in dermatomyositis. (2365526)
1990

Genetic Variations for Dermatomyositis

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Expression for genes affiliated with Dermatomyositis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dermatomyositis

Search GEO for disease gene expression data for Dermatomyositis.

Pathways for genes affiliated with Dermatomyositis

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Sources:
53Reactome, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Dermatomyositis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Dermatomyositis according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1pyrophosphate44 2412.2CMAS, UBA2, KARS, HARS, GARS, PIK3C2A
2Adenosine triphosphate11 2412.2UBA2, KARS, HARS, GARS, PIK3C2A, CHKB
3phosphoric acid44 2412.2UBA2, KARS, HARS, GARS, IARS, CMAS
4Adenosine monophosphate11 2412.1UBA2, KARS, HARS, GARS, IARS
5polysaccharide4411.1SFTPD, ICAM1, CHKB, CMAS, VCAM1
6fluvastatin44 49 28 1114.1ICAM1, PIK3C2A, CHKB, VCAM1
7pravastatin44 49 28 11 2415.1VCAM1, CHKB, PIK3C2A, ICAM1
8alanine4411.0CCR7, KARS, GARS, PIK3C2A, CHKB, VCAM1
9atorvastatin44 49 28 11 2415.0VCAM1, CHKB, PIK3C2A, ICAM1
10prednisolone44 28 1113.0VCAM1, CHKB, PIK3C2A, SFTPD
11simvastatin44 49 59 28 11 2416.0ICAM1, PIK3C2A, CHKB, VCAM1
12lactate4411.0SFTPD, ICAM1, PIK3C2A, CHKB, VCAM1
13endotoxin4411.0SFTPD, ICAM1, CHKB, VCAM1
14aminoacyl-trna4411.0KARS, GARS, IARS
15budesonide44 49 1113.0SFTPD, ICAM1, VCAM1
16cerivastatin44 49 28 1114.0CHKB, PIK3C2A, ICAM1
17trna4410.9IARS, GARS, KARS
18fenofibrate44 49 1112.9VCAM1, PIK3C2A, ICAM1
19alpha-hydroxybutyrate4410.9PIK3C2A, CHKB
20thallium4410.9PIK3C2A, CHKB
21fibrinogen4410.9ICAM1, PIK3C2A, CHKB, VCAM1
22tetramethylpyrazine4410.8CHKB, ICAM1
23hydroxylysine4410.8SFTPD, CHKB
24sodium cromoglycate4410.8VCAM1, ICAM1
25dantrolene44 28 1112.8CHKB, PIK3C2A
26succinylcholine44 28 1112.7CHKB, PIK3C2A
278 methoxypsoralen4410.7VCAM1, ICAM1
28loratadine44 11 2412.6VCAM1, ICAM1
29anticodon4410.6GARS, KARS
30norepinephrine44 11 2412.6CCR7, CHKB
31gamma-hydroxybutyrate4410.5CHKB, PIK3C2A
32sele4410.3VCAM1, ICAM1

GO Terms for genes affiliated with Dermatomyositis

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Sources:
16Gene Ontology
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Cellular components related to Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.9IFIT3, IFIH1, UBA2, KARS, HARS, GARS
2cytosolGO:00582910.9IFIT3, IFIH1, KARS, HARS, GARS, PIK3C2A
3ER to Golgi transport vesicle membraneGO:01250710.7STX17, HLA-DQA1, HLA-DQA2
4NuRD complexGO:01658110.6CHD4, CHD3
5MHC class II protein complexGO:04261310.3HLA-DQA1, HLA-DQA2

Biological processes related to Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tRNA aminoacylation for protein translationGO:00641810.8IARS, GARS, HARS, KARS
2interferon-gamma-mediated signaling pathwayGO:06033310.7ICAM1, HLA-DQA2, HLA-DQA1, VCAM1
3cytokine-mediated signaling pathwayGO:01922110.7IFIT3, ICAM1, HLA-DQA2, HLA-DQA1, VCAM1
4modulation by virus of host morphology or physiologyGO:01904810.7VCAM1, KARS, ICAM1, IFIH1
5diadenosine tetraphosphate biosynthetic processGO:01596610.5GARS, KARS
6membrane to membrane dockingGO:02261410.3ICAM1, VCAM1

Molecular functions related to Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00552410.7IARS, IFIH1, UBA2, KARS, HARS, GARS
2MHC class II receptor activityGO:03239510.6HLA-DQA1, HLA-DQA2

Products for genes affiliated with Dermatomyositis

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Sources for Dermatomyositis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet