Dermatomyositis malady

NIH Rare Diseases: Dermatomyositis is one of a group of acquired muscle diseases called inflammatory myopathies (disorder of muscle tissue or muscles), which are characterized by chronic muscle inflammation accompanied by muscle weakness. The cardinal symptom is a skin rash that precedes or accompanies progressive muscle weakness. Dermatomyositis may occur at any age, but is most common in adults in their late 40s to early 60s, or children between 5 and 15 years of age. There is no cure for dermatomyositis, but the symptoms can be treated. Options include medication, physical therapy, exercise, heat therapy (including microwave and ultrasound), orthotics and assistive devices, and rest. The cause of dermatomyositis is unknown.³⁰

MalaCards: Dermatomyositis, also known as polymyositis with skin involvement, is related to childhood type dermatomyositis and adult dermatomyositis. An important gene associated with Dermatomyositis is GARS (glycyl-tRNA synthetase), and among its related pathways are Graft-versus-host disease and RAR-Gamma-RXR-Alpha Degradation. The drugs globulin,immune (iv) and potassium para-aminobenzoate and the compounds cyclophosphamide and glucose have been mentioned in the context of this disorder. Affiliated tissues include muscle or, heart and lung, and related mouse phenotypes are respiratory system and renal/urinary system.

Disease Ontology: A myositis that results in inflammation located in muscle or located in skin. the disease may result from either a viral infection or an autoimmune reaction.⁶

NINDS: Dermatomyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness. ³¹

Wikipedia: Dermatomyositis (DM) is a connective-tissue disease related to polymyositis (PM) that is characterized...⁴⁴ more...

Aliases & Descriptions:

dermatomyositis 6 30 31 8 32 43 polymyositis with skin involvement 6 dermatopolymyositis, unspecified 6

adult type dermatomyositis 43 dermatopolymyositis 6 polymyositis 43

Disease types for dermatomyositis family:

c9 deficiency with dermatomyositis

Diseases related to dermatomyositis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1002)

id	Related Disease	Score	Top Affiliating Genes
1	childhood type dermatomyositis	34.0	CMAS, ZFAT, IFIT3, HLA-DQA1, HLA-DQA2, STX17
2	adult dermatomyositis	33.8	PIK3C2A, VCAM1, CHKB, INS, IFIT3, ICAM1
3	inclusion body myositis	31.0	VCAM1, ICAM1, HLA-B, COX5A
4	myositis	30.7	PIK3C2A, SERPINA3, VCAM1, MYBPC1, UTRN, CHKA
5	interstitial lung disease	29.7	VTN, SFTPD, BMP6, IL1A, IL1RAPL2, IL1RN
6	calcinosis	29.6	PIK3C2A, MGP, MEPE, FBN1, GPT, CALCA
7	mixed connective tissue disease	29.5	PIK3C2A, MUC16, S100A8, S100A9, MICA, INS
8	polymyositis	29.1	PIK3C2A, VWF, SFTPD, SELE, SERPINA3, VEGFA
9	hypothyroidism	29.0	MET, IL1A, IFNA1, IFNB1, CALCA
10	primary biliary cirrhosis	28.9	GZMB, MBL2, GPT, HSPG2, HSPD1, HLA-B
11	duchenne muscular dystrophy	28.8	PIK3C2A, UTRN, CHKB, MB, TNNI3, DMD
12	arthritis	28.7	IL17A, IL1A, IL1B, IL6, TNF, TNFSF11
13	idiopathic myopathy	28.6	CHKB, IL1A, CCL2, HLA-B, AARS
14	connective tissue disease	28.2	SFTPD, BMP6, S100A9, FBL, FBN1, HSPG2
15	rheumatoid arthritis	28.2	IL1RN, MBL2, HLA-DRB1, CRP, TARS
16	muscular dystrophy	28.1	PIK3C2A, VWF, VEGFA, MYBPC1, UTRN, CHKA
17	hepatitis	27.7	VTN, GPT, IFNA1, SOD2, SLC17A5
18	tropical spastic paraparesis	27.6	IL15, IL2RA, CCL3, IFNB1, IFNG
19	t-cell leukemia	27.4	CD28, CD4, CD40, IL1A, IL2RA, FAS
20	juvenile rheumatoid arthritis	27.3	S100A8, S100A9, IL1A, IL1RAPL2, IL1RN, IL2RA
21	autoimmune thyroiditis	26.9	CHKB, CD59, CD40, IL2RA, IL4, FAS
22	polyarteritis nodosa	26.8	CHKB, MPO, IL6, GPT, IGES, IFNA1
23	was-related disorders	26.8	CHKB, MPO, INS, IL2RA, IL6, FBN1
24	lipodystrophy	26.0	CD4, INS, IL6, FBN1, FAS, CCL2
25	graft versus host disease	26.0	CD28, GZMB, IL10, IL15, IL1RAPL2, IL2RA
26	spastic paraparesis	25.9	VEGFA, CD8A, CD4, IL10, IL15, IL2RA
27	testicular cancer	25.4	BMP6, CGB, IL2RA, IL6, FAS, ALOX5
28	bronchiolitis obliterans	25.4	PIK3C2A, SFTPD, BMP6, CHKA, CHKB, MUC1
29	spasticity	25.4	VEGFA, CD8A, CD4, INS, IL10, IL15
30	myopathy	25.3	PIK3C2A, SELE, VCAM1, MYBPC1, UTRN, SDHB
31	hepatitis c	24.7	MX1, CD28, IL10, IL4, FAS, CCL8
32	polymyalgia rheumatica	24.3	VWF, SERPINA3, VEGFA, MX1, IL1A, IL1B
33	systemic lupus erythematosus	24.2	VWF, VTN, SELE, VCAM1, MX1, LAMP3
34	renal cell carcinoma	24.1	VEGFA, SDHB, CHKA, MUC1, CGB, CD86
35	immunodeficiency	23.1	BMP6, CLIP1, CD28, CD4, CD40, GZMB
36	arthropathy	22.8	VTN, BMP6, S100A8, S100A9, MICA, IL10
37	hyperthyroidism	22.7	PIK3C2A, VWF, SELE, SDHB, CHKB, CGB
38	bronchiolitis	22.3	PIK3C2A, SFTPD, SELE, VCAM1, BMP6, CHKA
39	barrett's esophagus	22.1	VEGFA, MUC1, S100A8, S100A9, MSH2, IL10
40	pulmonary hypertension	21.7	PIK3C2A, VWF, VEGFA, BMP6, IL10, IL1A
41	esophageal cancer	19.5	SERPINA3, VEGFA, BMP6, CHKA, MUC1, S100A9
42	vasculitis	19.5	VWF, SELE, SERPINA3, VEGFA, VCAM1, BMP6
43	pulmonary fibrosis	19.3	VWF, VTN, SFTPD, SELE, VEGFA, BMP6
44	pneumonia	18.7	PIK3C2A, VTN, SFTPD, SELE, VEGFA, VCAM1
45	lupus erythematosus	18.0	PIK3C2A, VWF, VTN, SFTPD, SELE, SERPINA3
46	hypertension	16.2	PIK3C2A, VWF, SELE, SERPINA3, VEGFA, VCAM1
47	esophagitis	16.1	PIK3C2A, SFTPD, SELE, SERPINA3, VEGFA, VCAM1
48	fibrosis	16.0	VWF, VTN, SFTPD, SELE, SERPINA3, VEGFA
49	pancreatic cancer	15.9	VWF, VTN, SELE, SERPINA3, VEGFA, VCAM1
50	melanoma	14.6	PIK3C2A, VWF, VTN, SELE, SERPINA3, VEGFA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 globulin,immune (iv), potassium para-aminobenzoate

MalaCards organs/tissues related to dermatomyositis:

²²

FMA organs/tissues related to dermatomyositis:

¹¹

MGI Mouse Phenotypes related to dermatomyositis:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.7	DMD, TNNI3, CALCA, MB, FBN1, MGP
2	renal/urinary system phenotype	MP:0005367	10.2	DMD, CTSL1, HELLS, THBS1, SOD2, PTHLH
3	craniofacial phenotype	MP:0005382	10.0	HDAC1, DSPP, PLXND1, DMP1, HSPG2, MBD4
4	embryogenesis phenotype	MP:0005380	9.9	HSP90AB1, PLXND1, KRT19, ABCB7, HELLS, MBD4
5	hematopoietic system phenotype	MP:0005397	9.8	HDAC2, HGF, ZFAT, CHD4, F2RL2, HLA-DQA1
6	endocrine/exocrine gland phenotype	MP:0005379	9.7	HDAC2, TLR2, DMD, IFNG
7	other phenotype	MP:0005395	9.6	ABCB7, TLR2, PRNP, CXCR3, SOD2, CTSL1
8	limbs/digits/tail phenotype	MP:0005371	9.0	TNFSF11, PTHLH, DMD, DMP1, PLXND1, HELLS
9	nervous system phenotype	MP:0003631	9.0	TLR2, ABCB7, KRT19, PLXND1, CTSL1, SPP1
10	no phenotypic analysis	MP:0003012	8.1	IFNB1, TP53, PTGS2, DMD, DMP1, SST
11	liver/biliary system phenotype	MP:0005370	7.7	TP53, DMD, CTSL1, ABCB7, TLR2, TLR4
12	digestive/alimentary phenotype	MP:0005381	7.7	THBS1, NPY, HDAC2, CCR5, CCL3, CCR7
13	adipose tissue phenotype	MP:0005375	7.7	PTHLH, DMD, HELLS, TLR2, TLR4, SQSTM1
14	normal phenotype	MP:0002873	7.7	HMGCR, HLA-DQB1, DMD, SST, TLR2, THBD
15	immune system phenotype	MP:0005387	7.5	SQSTM1, SOD2, HDAC1, HDAC2, VWF, CHD4
16	integument phenotype	MP:0010771	7.5	TNFSF11, PTGS1, PTHLH, CTSL1, KRT19, HELLS
17	skeleton phenotype	MP:0005390	7.2	VEGFA, TNFRSF11B, TNFRSF1B, TNFSF11, TNMD, PTGS2
18	growth/size phenotype	MP:0005378	7.1	HELLS, ABCB7, KRT19, PLXND1, SPP1, SST
19	muscle phenotype	MP:0005369	6.9	SPP1, DMD, PTGS1, PTGS2, TNNI3, TNMD
20	reproductive system phenotype	MP:0005389	6.5	DMD, PTGS1, PTGS2, TNFSF11, TNF, SPP1
21	behavior/neurological phenotype	MP:0005386	6.4	HELLS, PLXND1, CTSL1, SPP1, SST, DMD
22	vision/eye phenotype	MP:0005391	5.2	PTGS2, TNMD, TNFRSF1B, TNF, TP53, HMGB1
23	mortality/aging	MP:0010768	5.1	THBD, PRNP, CXCL9, CXCR3, SQSTM1, SLC17A5
24	homeostasis/metabolism phenotype	MP:0005376	4.8	UTRN, CHKA, MUC1, UCN2, MTA2, S100A9
25	tumorigenesis	MP:0002006	4.8	MUC1, MSH2, GZMB, MET, IL10, IL1A
26	cardiovascular system phenotype	MP:0005385	3.7	IL1B, IL1RN, IL6, FBN1, FAS, MB
27	cellular phenotype	MP:0005384	3.3	TNFRSF1B, THBD, THBS1, PRNP, CXCL10, CXCR3

Articles related to dermatomyositis:

(show top 50)    (show all 132)

id	Title	Authors	Year	Affiliating Genes
1	Enhanced skin expression of melanoma differentiation- associated gene 5 (MDA5) in dermatomyositis and related autoimmune diseases. (21496705)	Zahn S.... Wenzel J.	2011	IFIH1
2	The phenotypic profile of dermatomyositis and lupus e rythematosus: a comparative analysis. (19891658)	Magro C.M.... Chadwick P.	2010	CD83
3	Interferon-stimulated gene 15 (ISG15) conjugates prot eins in dermatomyositis muscle with perifascicular atrophy. (20186858)	Salajegheh M.... Greenberg S.A.	2010	ISG15, IFN1@
4	Lesional and nonlesional skin from patients with untr eated juvenile dermatomyositis displays increased numbers of mast cells and mat ure plasmacytoid dendritic cells. (20506305)	Shrestha S.... Pachman L.M.	2010	IFNA1
5	Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with disease activity at diagnosis and after thir ty-six months of therapy. (19479879)	Niewold T.B.... Pachman L.M.	2009	IFNA1
6	Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis. (18821695)	Grundtman C.... Lundberg I.E.	2008	VEGFA
7	Preliminary validation and clinical meaning of the Cutaneous Assessment Tool in juvenile dermatomyositis. (18240194)	Huber A.M.... Rider L.G.	2008	CAT
8	Clinical and HLA-class II haplotype associations of autoantibodies to small ubiquitin-like modifier enzyme, a dermatomyositis-specific autoantigen target, in UK adult-onset Caucasian myositis. (18930994)	Betteridge Z.E.... McHugh N.J.	2008	HLA-DQA1, HLA-DQB1, HLA-DRB1
9	Bone mineral apparent density in juvenile dermatomyositis: the role of lean body mass and glucocorticoid use. (18189194)	Santiago R.A.... Pereira R.M.	2008	TNFRSF11B, TNFSF11
10	Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis. (19035492)	Mamyrova G.... Rider L.G.	2008	TNF, IL1B, IL1A
11	Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis. (18448482)	Marhaug G.... Brogan P.A.	2008	SPP1
12	Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis. (17938031)	Lee L.A.... Hobbs K.F.	2007	INS
13	Tumor necrosis factor-alpha-308G/A promoter polymorphism is associated with the susceptibility of polymyositis/dermatomyositis in a Chinese Han population. (17408448)	Liu J.F.... Ou Y.J.	2007	TNF
14	Reduction expression of thrombomodulin and endothelial cell nitric oxide synthase in dermatomyositis. (17899683)	Shen G.L.... Yuan Y.	2007	THBD
15	HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap. (18003662)	Wedderburn L.R.... Davidson J.E.	2007	HLA-DQA1, HLA-DQB1, HLA-DRB1
16	Increased Fas and Bcl-2 expression on peripheral blood T and B lymphocytes from juvenile-onset systemic lupus erythematosus, but not from juvenile rheumatoid arthritis and juvenile dermatomyositis. (17162369)	Liphaus B.L.... Goldenstein-Schainberg C.	2006	FAS
17	Identification of autoantibodies elicited in a patient with prostate cancer presenting as dermatomyositis. (16643611)	Mooney C.J.... McNeel D.G.	2006	ACAA1
18	Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. (15856462)	Okada T.... Kawakami Y.	2005	MSH2, PMS1
19	Altered cytokine expression of peripheral blood lymphocytes in polymyositis and dermatomyositis. (15829578)	Aleksza M.... DankA^ K.	2005	IL4, IFNG
20	Intravenous cyclophosphamide pulse therapy in juvenil e dermatomyositis. A review of efficacy and safety. (14722349)	Riley P.... Pilkington C.A.	2004	GPT
21	Infiltrating cells, related cytokines and chemokine receptors in lesional skin of patients with dermatomyositis. (15491417)	Caproni M.... Fabbri P.	2004	CD4, MPO, CD40
22	Immunolocalization of protectin (CD59) and macrophages in polymyositis and dermatomyositis. (15020079)	Gendek-Kubiak H.... Gendek E.G.	2004	CD59
23	Quantitative assessment of MRI T2 relaxation time of thigh muscles in juvenile dermatomyositis. (14983103)	Maillard S.M.... Murray K.J.	2004	CHKB
24	Association of the proinflammatory haplotype (MICA5.1/TNF2/TNFa2/DRB1*03) with polymyositis and dermatomyositis. (15022353)	Hassan A.B.... Padyukov L.	2004	TNF, HLA-DRB1, MICA
25	A case of dermatomyositis associated with different types of cancers at intervals of six years (15678898)	Hashimoto M.... Mimori T.	2004	CHKA
26	Cytokines in juvenile dermatomyositis pathophysiology: potential and challenge. (14569197)	Uzel G.... Pachman L.M.	2003	THBS1, BMP6, IL15
27	HLA class II haplotypes associated with pulmonary interstitial lesions of polymyositis/dermatomyositis in Japanese patients. (11972875)	Horiki T.... Inoko H.	2002	HLA-DQA1, HLA-DQB1, HLA-DRB1
28	A case of amyopathic dermatomyositis with systemic sclerosis sine scleroderma presenting abnormal vermiculation (12355862)	Kubo N.... Hayashi J.	2002	PIK3C2A
29	Increased IL-15 production of muscle cells in polymyositis and dermatomyositis. (12147628)	Sugiura T.... Kamatani N.	2002	IL15
30	Increased plasma thrombospondin-1 (TSP-1) levels are associated with the TNF alpha-308A allele in children with juvenile dermatomyositis. (12173300)	Lutz J.... Pachman L.M.	2002	TNF, THBS1
31	Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesis. (11937576)	Tezak Z.... Pachman L.M.	2002	THBS4
32	Clinical significance of serum surfactant protein D (SP-D) in patients with polymyositis/dermatomyositis: correlation with interstitial lung disease. (12421999)	Ihn H.... Tamaki K.	2002	SFTPD
33	Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)	Wiesinger G.F.... Graninger W.	2000	PIK3C2A
34	Dermatomyositis after interferon alpha treatment. (10713663)	Dietrich L.L.... Albertini M.R.	2000	IFNA1
35	Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. (11055823)	Shimizu T.... Horie T.	2000	TNFRSF1B
36	Diagnosis of dermatomyositis and polymyositis: a study of 102 cases. (11018813)	Scola R.H.... Iwamoto F.M.	2000	CHKB
37	Abnormal IL-1 receptor antagonist production in patie nts with polymyositis and dermatomyositis. (10732829)	Son K.... Horie T.	2000	IL1RN
38	Dermatomyositis and drugs. (10599342)	Dourmishev A.L.... Dourmishev L.A.	1999	HMGCR
39	Dermatomyositis with erosive arthropathy: association with the anti-PL-7 antibody. (10606385)	Wasko M.C.... Oddis C.V.	1999	TARS
40	The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. (9790534)	Zhang Y.... Reinberg D.	1998	HDAC2, HDAC1, RBBP4
41	Cardiac rhythm and conduction disorders in polymyositis and dermatomyositis (9865014)	Bazhanov N.N.... Makolkin V.I.	1998	MB
42	Histological and biochemical assessment of mitochondrial function in dermatomyositis. (9825742)	MirA^ O.... Cardellach F.	1998	SDHB
43	Immunogenetic studies in families of children with juvenile dermatomyositis. (9598907)	Reed A.M.... Ober C.	1998	HLA-DQA1, HLA-DRB1
44	The immunopathologic and inflammatory differences between dermatomyositis, polymyositis and sporadic inclusion body myositis. (8839618)	Dalakas M.C.... Sivakumar K.	1996	HELLS
45	Elevated serum levels of manganese superoxide dismutase in polymyositis and dermatomyositis. (8628497)	Mokuno K.... Kato K.	1996	SOD2
46	Incidence of anti Hsp 90 and 70 antibodies in children with SLE, juvenile dermatomyositis and juvenile chronic arthritis. (8697668)	Conroy S.E.... Isenberg D.A.	1996	HSP90AB1
47	Dermatomyositis as a complication of a metastatic me lanoma-- case report and review of the literature (7698809)	Lersch C.... Schepp W.	1995	PIK3C2A
48	von Willebrand factor in juvenile dermatomyositis. (7738956)	Bloom B.J.... Schaller J.G.	1995	PIK3C2A
49	Humoral immunity in polymyositis/dermatomyositis. (8423380)	Targoff I.N.	1993	AARS
50	Dystrophin abnormalities in polymyositis and dermatomyositis. (1822343)	Sewry C.A.... Strong P.N.	1991	DMD

Genes related to dermatomyositis according to GeneCards:

(show top 50)    (show all 164)

id	Symbol	Description	Score	GeneCards Section Context
1	GARS	glycyl-tRNA synthetase	11.0	Summaries, Functions
2	IFIH1	interferon induced with helicase C domain 1	11.0	Aliases & Descriptions, Publications
3	HARS	histidyl-tRNA synthetase	11.0	Summaries, Functions
4	IARS	isoleucyl-tRNA synthetase	11.0	Summaries, Functions
5	CHD4	chromodomain helicase DNA binding protein 4	11.0	Summaries, Publications
6	KARS	lysyl-tRNA synthetase	11.0	Functions, Summaries
7	CHD3	chromodomain helicase DNA binding protein 3	11.0	Publications, Summaries
8	YTHDF1	YTH domain family, member 1	11.0	Aliases & Descriptions
9	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
10	CHKB	choline kinase beta	11.0	Publications
11	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
12	ICAM1	intercellular adhesion molecule 1	11.0	Publications
13	CMAS	cytidine monophosphate N-acetylneuraminic acid synthetase	11.0
14	IFIT3	interferon-induced protein with tetratricopeptide repeats 3	11.0
15	TARS	threonyl-tRNA synthetase	11.0	Publications
16	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
17	FBL	fibrillarin	11.0
18	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0	Publications
19	CD59	CD59 molecule, complement regulatory protein	11.0	Publications
20	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0	Publications
21	CCR7	chemokine (C-C motif) receptor 7	11.0	Publications
22	C9	complement component 9	11.0	Publications
23	THBS1	thrombospondin 1	11.0	Publications
24	SFTPD	surfactant protein D	11.0	Publications
25	GAA	glucosidase, alpha; acid	11.0
26	IL17A	interleukin 17A	11.0	Publications
27	HELLS	helicase, lymphoid-specific	11.0	Publications
28	S100A9	S100 calcium binding protein A9	11.0
29	CHKA	choline kinase alpha	11.0	Publications
30	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0
31	VTN	vitronectin	11.0	Publications
32	CD86	CD86 molecule	11.0
33	MUC16	mucin 16, cell surface associated	11.0	Publications
34	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.0	Publications
35	IL1A	interleukin 1, alpha	11.0	Publications
36	MB	myoglobin	11.0	Publications
37	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0	Publications
38	CD28	CD28 molecule	11.0
39	S100A8	S100 calcium binding protein A8	11.0
40	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
41	FBN1	fibrillin 1	11.0
42	CCL3	chemokine (C-C motif) ligand 3	11.0
43	HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	11.0
44	TNF	tumor necrosis factor	11.0	Publications
45	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
46	HSPA8	heat shock 70kDa protein 8	11.0
47	PRNP	prion protein	11.0
48	UTRN	utrophin	11.0
49	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
50	INS	insulin	11.0	Publications

Pathways related to dermatomyositis according to GeneDecks:

(show top 50)    (show all 115)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	11.0	CD28, CD86, IL1A, HLA-B, HLA-DQA1, HLA-DQA2
2	RAR-Gamma-RXR-Alpha Degradation36	10.8	CXCL9, IL15, IL23A, CCL8, CCL3, CCL21
3	DNA Methylation and Transcriptional Repression36	10.5	MBD3, HDAC2, HDAC1, MBD2, CHD4, RBBP4
4	Transcription_Sin3 and NuRD in transcription regulation41	10.5	CHD3, MBD2, MBD3, SIN3A, HDAC1, MTA2
5	Transcription Sin3 and NuRD in transcription regulation10	10.4	MTA2, HDAC2, HDAC1, RBBP7, RBBP4, CHD4
6	Antigen processing and presentation20	10.4	HLA-DRB1, HLA-DQB1, CD8A, CD4, HSP90AA1, HSP90AB1
7	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.3	CCL3, IL2RA, IL15, GZMB
8	Bacterial infections in CF airways41	10.0	MUC1, TLR2, CTSL1, SFTPD
9	Asthma20	9.7	HLA-DRB1, HLA-DQA2, RNASE3, TNF, HLA-DQB1, CD40
10	NFAT Signaling and Lymphocyte Interactions36	9.7	IL15, IL23A, IL1A, CD4, BMP6, CCL8
11	Autoimmune thyroid disease20	9.6	FAS, IFNA1, HLA-B, HLA-DQA1, HLA-DQA2, HLA-DQB1
12	PGC1Alpha Pathway36	9.4	IL4, CCL8, CCL3, CCL21, CCL19, TNFRSF1B
13	THC Differentiation Pathway36	9.4	CD28, CD86, IL10, IL2RA, IL4, IFNG
14	Type I diabetes mellitus20	9.3	TNF, HLA-DRB1, HLA-DQB1, CD28, CD86, GZMB
15	IL-6 Pathway36	9.3	BMP6, IL10, IL23A, IL4, CCL8, CCL2
16	Allograft rejection20	9.2	CD28, CD86, CD40, GZMB, IL10, IL4
17	Intestinal immune network for IgA production20	9.1	IL6, IL4, IL15, IL10, CD40, CD86
18	Regulation of eIF4 and p70S6K36	9.0	CCL19, IL6, IL23A, IL4, IL15, CCL8
19	Toxoplasmosis20	8.9	HLA-DQA2, HSPA8, ALOX5, IFNG, TLR2, HLA-DQA1
20	Toll-like receptor signaling pathway20	8.7	CXCL11, IL6, TLR9, CD40, IL1B, CCL3
21	Molecular Mechanisms of Cancer36	8.4	BMP6, CD4, MEPE, MET, CCL21, CCR7
22	Rho Family GTPases36	8.3	HSPG2, CCL21, CCL19, CXCL9, CXCL11, CXCL10
23	Th17 Differentiation37	8.3	IL6, TLR2, TLR4, TLR9, CD28, IL23A
24	Influenza A20	8.3	CXCL10, TLR4, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA2
25	Endothelin-1 Signaling Pathway36	8.2	BMP6, CXCL9, CXCL11, CXCL10, IL10, IL1A
26	Leishmaniasis20	8.2	TLR4, IFNG, IL10, IL1A, IL1B, IL4
27	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.2	TLR4, GZMB, IL17A, IL1B, IL23A, TLR2
28	ERK Signaling36	8.1	BMP6, TNFSF11, SPP1, CXCL10, CXCL11, IL1B
29	Akt Signaling36	8.0	CXCL11, IL10, MET, CD4, CD28, IL15
30	African trypanosomiasis20	7.9	IL6, TLR9, TNF, IFNG, FAS, IL1B
31	Rheumatoid arthritis20	7.8	TLR4, CCL3, IFNG, ICAM1, HLA-DQA1, HLA-DQA2
32	Cytokine Network36	7.8	IL10, IL15, IL1A, IL1B, TNF, IL4
33	SOCS Pathway36	7.7	CCL19, IL10, INS, BMP6, IL1A, IL1B
34	Tuberculosis20	7.6	IL1A, IL1B, IL23A, IL6, TLR9, TLR4
35	PEDF Induced Signaling36	7.6	BMP6, IL10, IL15, IL1A, IL1B, IL23A
36	Glucocorticoid Receptor Signaling36	7.6	BMP6, CD4, IL10, IL15, IL1A, IL1B
37	Malaria20	7.6	HGF, THBS4, VCAM1, CD40, MET, IL10
38	Tec Kinases Signaling36	7.5	IL23A, IL2RA, IL4, IL6, CCL8, CCL2
39	PAK Pathway36	7.4	CXCL9, HGF, IL1B, CXCL11, CCL8, TNFSF11
40	all-trans-Retinoic Acid Signaling in Brain36	7.3	CCL21, ALOX5, HGF, CXCL9, CXCL11, CXCL10
41	MIF Mediated Glucocorticoid Regulation36	7.3	HGF, CXCL9, CXCL11, CXCL10, TLR4, PTGS2
42	MIF Regulation of Innate Immune Cells36	7.3	CXCL9, HGF, CXCL11, CXCL10, CCL3, BMP6
43	TGF-Beta Pathway36	7.2	HGF, CCL21, CCL3, CCL2, CCL19, TNFRSF1B
44	Measles20	7.2	IFNG, IFNB1, IFNA1, IFIH1, FAS, IL6
45	STAT3 Pathway36	7.1	CCR7, CCL19, TNF, TNFRSF1B, TNFSF11, CXCL10
46	MAPK Family Pathway36	7.1	IL15, BMP6, CD4, MET, IL10, HGF
47	Antioxidant Action of Vitamin-C36	7.1	CCL3, IL4, IL2RA, IL23A, IL1B, IL1A
48	p38 Signaling36	6.6	IL23A, CXCL9, CXCR3, HGF, CXCL11, CXCL10
49	JAK-STAT Pathway36	6.6	IL6, IFNG, IFNB1, IFNA1, CCL8, IL2RA
50	Cytokine-cytokine receptor interaction20	6.0	IL6, FAS, CCL8, CCL2, CCR5, CCL3

Compounds related to dermatomyositis according to GeneDecks:

(show top 50)    (show all 462)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.8	MBL2, CXCL9
2	glucose32	10.7	MUC16, UCN2, CGB, GZMB, F2RL2, PTHLH
3	sp 60012532 42	11.2	VCAM1, CD40, IL17A, TP53, TLR2
4	ivig32	10.1	PIK3C2A, VWF, IL1RAPL2, CCR5, IFNB1, CRP
5	dmso32	9.9	BMP6, SDHB, S100A9, F2RL2, ALOX5, HSPG2
6	epinephrine32 9 18 9	12.9	PIK3C2A, VTN, SELE, BMP6, SDHB, CHKB
7	polyethylene glycol32	9.8	VTN, SELE, CHKB, MUC1, MPO, MB
8	h2o232	9.8	VWF, SDHB, MUC16, S100A9, MPO, CD40
9	sodium nitroprusside32	9.7	PIK3C2A, VWF, BMP6, CD40, MB, HSPA8
10	fluvastatin32 34 9 9	12.7	PIK3C2A, VWF, VCAM1, CHKB, CD40, IL1A
11	fmlp32	9.7	SERPINA3, VCAM1, S100A9, MPO, CD59, IL1A
12	estrogen32	9.7	VWF, SERPINA3, CHKA, CHKB, MTA2, CGB
13	ascorbic acid32 18	10.6	SDHB, CHKA, CHKB, IL1A, IL2RA, FBN1
14	latex32	9.4	VWF, VTN, CHKB, IL1RN, MBL2, CCR5
15	heparan sulfate32 18	10.4	VTN, BMP6, CD4, GZMB, MET, FBN1
16	pge232	9.3	VTN, SELE, VCAM1, CD86, CD4, CD83
17	peptidoglycan32	9.3	IL10, IL15, IL1B, IL1RN, MBL2, CCL8
18	pravastatin32 34 9 18 9	13.3	PIK3C2A, SELE, CHKA, CHKB, IL6, CCL2
19	rapamycin32 42	10.3	VEGFA, UBASH3B, CD86, GZMB, INS, MET
20	arginine32	9.3	PIK3C2A, VWF, VTN, SERPINA3, UTRN, SDHB
21	cysteine32	9.2	VTN, SFTPD, SERPINA3, SDHB, CHKB, MUC1
22	glutamate32	9.1	VTN, BMP6, SDHB, CHKA, UCN2, S100A8
23	atp32	8.8	PIK3C2A, VTN, MYBPC1, SDHB, CHKA, CHKB
24	thyroxine32 18	9.7	PIK3C2A, VWF, SERPINA3, CHKA, CHKB, CGB
25	calcium32 9 18 9	11.7	PIK3C2A, VWF, VTN, SFTPD, SERPINA3, MYBPC1
26	leukotriene b432 42 18	10.5	MPO, IL1A, IL1B, IL1RAPL2, IL1RN, IL6
27	ribavirin32 34 9 9	11.4	MX1, IL10, IL4, MBL2, CCR5, CCL3
28	okt332	8.3	SELE, VCAM1, BMP6, IL10, IL15, IL2RA
29	fibrinogen32	8.2	PIK3C2A, VTN, SELE, SERPINA3, VCAM1, CHKB
30	imiquimod32 42 9 9	10.9	BMP6, MX1, IL10, IL1A, IL1RAPL2, IL6
31	polyinosinic-polycytidylic acid32	7.7	SELE, VCAM1, CD83, CD40, IL10, IL15
32	ifn-alpha32	7.7	MX1, IL10, IL17A, IL2RA, IL6, FAS
33	pd 98,05932	7.5	VTN, VCAM1, BMP6, CD40, MET, IL17A
34	pentoxifylline32 9 9	9.5	VCAM1, BMP6, MPO, IL10, IL1A, IL1B
35	prostacyclin32	7.5	PIK3C2A, VWF, VTN, SELE, VEGFA, VCAM1
36	poly(i-c)32	7.5	VCAM1, MX1, IL15, IL1B, IL4, IL6
37	creatinine32	7.4	VWF, SELE, SERPINA3, BMP6, UTRN, SDHB
38	cholesterol32 9 18 9	10.4	PIK3C2A, VWF, VTN, SFTPD, SELE, SERPINA3
39	gm-csf32	7.0	VEGFA, BMP6, IL10, IL15, IL1A, IL1B
40	alanine32	6.9	PIK3C2A, VWF, VTN, SELE, VCAM1, BMP6
41	polymyxin b32	6.8	SELE, VCAM1, IL10, IL1A, IL1B, IL1RN
42	prednisolone32 9 9	8.8	PIK3C2A, VWF, SFTPD, VCAM1, BMP6, CHKB
43	hydrocortisone32 9 9	8.7	BMP6, MUC1, CD40, INS, IL10, IL15
44	lipid32	6.7	PIK3C2A, VTN, SFTPD, SELE, SERPINA3, VCAM1
45	neopterin32	6.6	CHKB, MX1, CD4, CD40, GZMB, IL10
46	pdtc32	6.4	SELE, VCAM1, CD40, MET, IL1A, IL1B
47	il 1032	6.4	BMP6, CD8A, CD40, IL10, IL15, IL1A
48	simvastatin32 34 42 9 18 9	11.4	PIK3C2A, VWF, SELE, VEGFA, VCAM1, BMP6
49	retinoic acid32 42 18	8.1	VWF, VTN, VCAM1, BMP6, CHKA, S100A8
50	thymidine32 18	7.0	SFTPD, BMP6, CHKA, CHKB, MUC1, CD40

Cellular components related to dermatomyositis according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	NuRD complex	GO:016581	10.5	HDAC2, HDAC1, MBD3, MTA2, CHD3, CHD4
2	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.4	HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-B
3	MHC class II protein complex	GO:042613	10.3	HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
4	Sin3 complex	GO:016580	10.3	RBBP4, SIN3A, HDAC1, HDAC2
5	ER to Golgi transport vesicle membrane	GO:012507	10.3	HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-B
6	cell surface	GO:009986	9.7	HMGB1, TNF, DMD, TLR2, THBD, HSPD1
7	secretory granule	GO:030141	9.3	GARS, THBS1, HSPD1, IL1B, INS, MPO
8	integral to plasma membrane	GO:005887	9.2	TMEM11, TNFSF11, TNF, HLA-DRB1, HLA-DQA2, PLXND1
9	external side of plasma membrane	GO:009897	8.9	IL4, FAS, CCR5, CCR7, IFNG, ICAM1
10	cytosol	GO:005829	8.5	TP53, TRIM24, CAT, CARS, HSPD1, HSPA8
11	plasma membrane	GO:005886	8.4	HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-B, CAT, HSPA8
12	cytoplasm	GO:005737	7.3	TP53, TNFSF11, PTGS2, PTGS1, PTHLH, TROVE2
13	extracellular region	GO:005576	5.6	CD163, IBSP, F2RL2, HSPG2, CALCA, HMGB1
14	extracellular space	GO:005615	4.8	VTN, IL15, IL17A, IL1A, IL1B, IL1RN

Biological processes related to dermatomyositis according to GeneDecks:

(show top 50)    (show all 75)

id	Name	GO ID	Score	Top Affiliating Genes
1	tRNA aminoacylation for protein translation	GO:006418	11.0	GARS, HARS, AARS, TARS, CARS, IARS
2	positive regulation of protein kinase B signaling cascade	GO:051897	10.9	THBS1, TNFSF11, TNF, CCL19, CCR7, CCL21
3	positive regulation of neutrophil chemotaxis	GO:090023	10.7	IL23A, CCL21, CCR7, CCL19, THBS4
4	chronic inflammatory response	GO:002544	10.6	VCAM1, S100A8, S100A9, THBS1
5	T cell costimulation	GO:031295	10.6	HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, CCL19, CCL21
6	dendritic cell chemotaxis	GO:002407	10.5	HMGB1, CCL19, CCR7, CCL21, CCR5
7	interferon-gamma-mediated signaling pathway	GO:060333	10.2	HLA-DRB1, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-B, ICAM1
8	positive regulation of interleukin-10 production	GO:032733	10.2	TLR9, TLR4, HSPD1, IL4, IL23A, CD83
9	positive regulation of osteoclast differentiation	GO:045672	10.1	IL23A, IFNG, TNF, TNFSF11, IL17A
10	innate immune response	GO:045087	10.1	HSP90AB1, HMGB1, CTSL1, C9, TLR2, TLR4
11	positive regulation of JNK cascade	GO:046330	10.1	TLR9, TLR4, TNF, CCL19, CCR7, CCL21
12	chemotaxis	GO:006935	10.1	CXCR3, CXCL9, CXCL11, CXCL10, CCL3, CCR5
13	positive regulation of interleukin-2 biosynthetic process	GO:045086	10.1	IL1B, IL1A, CD4, CD86, CD28
14	positive regulation of mitosis	GO:045840	10.0	TNF, IL1B, IL1A, MET, INS, CD28
15	positive regulation of tumor necrosis factor production	GO:032760	10.0	TLR9, TLR4, TLR2, IFNG, CCL19, CCL3
16	positive regulation of interleukin-12 production	GO:032735	10.0	TLR9, TLR4, TLR2, HSPD1, IFNG, CCL19
17	response to virus	GO:009615	9.9	TNF, IFNG, IFNB1, IFIT3, IFIH1, CCL19
18	positive regulation of NF-kappaB import into nucleus	GO:042346	9.9	TLR9, TLR4, TLR2, TNF, CCL19, IL23A
19	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.9	TLR9, TLR4, TNFSF11, TNF, CCL19, CCR7
20	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.9	TLR4, TNF, CCL19, CCR7, CCL21, CCL3
21	response to organic cyclic compound	GO:014070	9.8	PTGS2, ICAM1, CCL19, IL4, IL1RN, IL1A
22	response to lipopolysaccharide	GO:032496	9.8	CXCL10, THBD, TLR4, PTGS2, CCR7, FAS
23	lipopolysaccharide-mediated signaling pathway	GO:031663	9.6	TLR4, TLR2, TNF, CCL3, CCL2, IL1B
24	acute-phase response	GO:006953	9.6	CRP, MBL2, IL6, IL1RN, INS, CD163
25	negative regulation of growth of symbiont in host	GO:044130	9.5	TLR2, IL10, MBL2, IFNG, TNF
26	virus-host interaction	GO:019048	9.5	HSPD1, HLA-B, TP53, KRT19, HDAC1, HSPA8
27	positive regulation of chemokine production	GO:032722	9.5	IL6, TNF, TLR2, TLR4, TLR9
28	monocyte chemotaxis	GO:002548	9.5	TNFSF11, CALCA, CCL3, CCL2, IL6
29	response to organic nitrogen	GO:010243	9.4	SIN3A, PTGS1, PTGS2, IL1RN, IL1B, IL1A
30	aging	GO:007568	9.3	SIN3A, PTGS1, HMGCR, CALCA, CCL2, FAS
31	immune response	GO:006955	9.3	CXCL9, CCL8, IL4, IL2RA, IL1RN, IL1A
32	defense response to virus	GO:051607	9.3	CXCL9, CXCL10, IFNG, IFNB1, IL6, MICA
33	humoral immune response	GO:006959	9.2	TNF, IFNG, IFNB1, CCL2, IL6, CD83
34	positive regulation of nitric oxide biosynthetic process	GO:045429	9.1	TLR4, TLR2, PTGS2, TNF, HSP90AB1, HSP90AA1
35	cell-cell signaling	GO:007267	9.1	CCL3, CCL21, CALCA, PTHLH, SST, CXCL10
36	cellular response to lipopolysaccharide	GO:071222	9.1	TLR4, TNFRSF1B, ICAM1, IFNG, CCR5, CCL2
37	positive regulation of interleukin-6 production	GO:032755	9.1	TLR9, TLR4, TLR2, TNF, HSPD1, IL6
38	positive regulation of interleukin-8 production	GO:032757	9.0	TLR9, TLR4, TLR2, CALCA, IL1B
39	cell surface receptor signaling pathway	GO:007166	9.0	CXCL10, SST, IFNG, IFNB1, CCR5, CCL2
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.9	TNFSF11, TLR2, TLR4, TLR9, TNF, CAT
41	response to hypoxia	GO:001666	8.7	CAT, TNF, CRP, TLR4, THBS1, CCL2
42	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.6	HGF, THBS4, TLR4, TP53, IL6, INS
43	positive regulation of T cell proliferation	GO:042102	8.6	IFNG, CCL19, IL6, IL4, IL23A, IL1B
44	anti-apoptosis	GO:006916	8.6	TNF, THBS1, PRNP, SQSTM1, HDAC1, HGF
45	cytokine-mediated signaling pathway	GO:019221	8.6	ICAM1, HLA-B, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
46	response to drug	GO:042493	8.1	ICAM1, TNF, TNFRSF11B, PTGS2, SST, THBS1
47	response to glucocorticoid stimulus	GO:051384	8.1	PTGS2, TNF, HMGB1, CCL2, FAS, IL6
48	negative regulation of apoptotic process	GO:043066	8.0	TNF, THBS1, SOD2, SIN3A, HDAC1, HDAC2
49	inflammatory response	GO:006954	7.0	CXCL9, CXCL11, CXCL10, IL23A, IL1B, IL1A
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.6	HMGB1, TP53, TNF, TNFSF11, TLR2, TLR4

Molecular functions related to dermatomyositis according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	integrin binding	GO:005178	10.4	THBS4, THBS1, DMP1, ICAM1, VCAM1, VTN
2	MHC class II receptor activity	GO:032395	10.3	HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1
3	chemokine activity	GO:008009	10.2	CXCL9, CXCL11, CXCL10, CCL19, CCL21, CCL3
4	coreceptor activity	GO:015026	10.1	CCR5, CD4, CD8A, CD86, CD28
5	interleukin-1 receptor binding	GO:005149	9.5	TLR9, IL1RN, IL1B, IL1A
6	cytokine activity	GO:005125	6.7	IL23A, IL4, IL6, IFNB1, IFNG, HMGB1
7	protein binding	GO:005515	6.1	HSP90AA1, TMEM11, DMD, CTSL1, CRP, KRT19