DM
MCID: DRM010
MIFTS: 68

Dermatomyositis (DM) malady

Rare diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Skin diseases, Muscle diseases categories
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Summaries for Dermatomyositis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Dermatomyositis is one of a group of acquired muscle diseases called inflammatory myopathies (disorder of muscle tissue or muscles), which are characterized by chronic muscle inflammation accompanied by muscle weakness. the cardinal symptom is a skin rash that precedes or accompanies progressive muscle weakness. dermatomyositis may occur at any age, but is most common in adults in their late 40s to early 60s, or children between 5 and 15 years of age. there is no cure for dermatomyositis, but the symptoms can be treated. options include medication, physical therapy, exercise, heat therapy (including microwave and ultrasound), orthotics and assistive devices, and rest. the cause of dermatomyositis is unknown. last updated: 8/26/2013

MalaCards: Dermatomyositis, also known as polymyositis with skin involvement, is related to polymyositis and interstitial lung disease, and has symptoms including cardiac rhythm disorder/arrhythmia, angor pectoris/myocardial infarction and vascularitis/vasculitides/arteritis. An important gene associated with Dermatomyositis is IFIH1 (interferon induced with helicase C domain 1), and among its related pathways are Malaria and Thromboxane A2 receptor signaling. The compounds anticodon and tetramethylpyrazine have been mentioned in the context of this disorder. Affiliated tissues include muscle or, skin and lung.

Disease Ontology:8 A myositis that results in inflammation located in muscle or located in skin where a skin rash is often seen prior to the onset of muscle weakness. the disease may result from either a viral infection or an autoimmune reaction.

NINDS:44 Dermatomyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness.

Wikipedia:65 Dermatomyositis (DM) is a connective-tissue disease related to polymyositis (PM) that is characterized... more...

Aliases & Classifications for Dermatomyositis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

49
dermatomyositis:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

dermatomyositis 8 43 44 10 45 49
polymyositis with skin involvement 8
dermatopolymyositis, unspecified 8
adult type dermatomyositis 62
dermatopolymyositis 8
dm 49


External Ids:

Disease Ontology8 DOID:10223
ICD9CM27 710.3
NCIt40 C26744
SNOMED-CT via Orphanet59 396230008, 402425006, 396229003
UMLS via Orphanet63 C0011633
MESH via Orphanet36 D003882
ICD10 via Orphanet26 M33.0, M33.1
ICD1025 M33, M33.9

Related Diseases for Dermatomyositis

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17GeneCards, 18GeneDecks
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Diseases in the Dermatomyositis family:

Adult Dermatomyositis

Diseases related to Dermatomyositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 290)
idRelated DiseaseScoreTop Affiliating Genes
1polymyositis31.3HARS, SFTPD, VCAM1, CHKB, ICAM1, CCR7
2interstitial lung disease31.2SFTPD, HARS
3myositis31.0HARS, VCAM1, CHKB, ICAM1, GARS
4inclusion body myositis30.8VCAM1, ICAM1
5myopathy30.7SDHB, CHKB, GARS
6diabetes mellitus30.7IFIH1, ICAM1, VCAM1, HLA-DQA1
7systemic lupus erythematosus30.5CCR7, ICAM1, VCAM1, HLA-DQA1
8melanoma30.5VCAM1, CHKB, ICAM1, CCR7, IFIH1
9rheumatoid arthritis30.3SFTPD, VCAM1, CHKB, ICAM1, CCR7
10dermatitis30.1ICAM1, VCAM1, HARS
11influenza30.0SFTPD, CCR7, IFIH1
12psoriasis30.0VCAM1, ICAM1, CCR7
13systemic scleroderma29.9ICAM1, VCAM1, SFTPD
14multiple sclerosis29.8HLA-DQA1, VCAM1, ICAM1, CCR7
15autoimmune thyroiditis29.8ICAM1, CHKB
16respiratory failure29.7ICAM1, SFTPD
17amyopathic dermatomyositis10.9
18adult dermatomyositis10.7
19calcinosis10.7
20lupus erythematosus10.5
21pneumonia10.5
22myotonic dystrophy10.5
23childhood type dermatomyositis10.5
24scleroderma10.4
25arthritis10.4
26panniculitis10.4
27breast cancer10.3
28adenocarcinoma10.2
29skin disease10.2
30multicentric reticulohistiocytosis10.2
31pneumatosis cystoides intestinalis10.2
32connective tissue disease10.2
33fasciitis10.2
34lipodystrophy10.2
35pityriasis rubra pilaris10.2
36nasopharyngitis10.2
37vasculitis10.2
38germ cell cancer10.2
39diabetes insipidus10.2
40maturity-onset diabetes of the young10.2
41congenital myotonic dystrophy10.2
42pemphigus10.1
43cutaneous lupus erythematosus10.1
44esophagitis10.1
45glomerulonephritis10.1
46hypertrichosis10.1
47lung cancer10.1
48purpura10.1
49testicular cancer10.1
50thyroiditis10.1

Graphical network of the top 20 diseases related to Dermatomyositis:



Diseases related to dermatomyositis

Symptoms for Dermatomyositis

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49Orphanet
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Symptoms:

49 (show all 50)
  • cardiac rhythm disorder/arrhythmia
  • angor pectoris/myocardial infarction
  • vascularitis/vasculitides/arteritis
  • gangrena/necrosis
  • elocution disorders/dysarthria/dysphonia
  • eosinophils anomalies/hypereosinophilia
  • neoplasms/tumors
  • lung/bronchopulmonary neoplasm/tumor/carcinoma/cancer
  • breast neoplasm/tumor/carcinoma/cancer
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • gastrointestinal stromal tumor
  • lymphoma
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • myocardium anomalies/myocarditis
  • lung fibrosis
  • nails anomalies
  • hypotrichosis/atrichia/atrichiasis/scalp hairlessness
  • telangiectasic erythema/poikiloderma
  • pruritus/itching
  • follicular/erythematous/edematous papules/milium
  • chronic skin infection/ulcerations/ulcers/cancrum
  • dry/squaly skin/exfoliation
  • autoimmunity/autoimmune reaction/autoantibodies
  • abnormal emg/electromyogram/electropmyography
  • myalgia/muscular pain
  • muscle weakness/flaccidity
  • cutaneous edema
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • palpebral edema/periorbital edema
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • abnormal cry/voice/phonation disorder/nasal speech
  • pulmonary hypertension
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • telangiectasiae of the skin
  • skin photosensitivity
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • skin hypoplasia/aplasia/atrophy
  • asthenia/fatigue/weakness
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • periarticular tissue anomaly/extraarticular calcifications
  • arthritis/synovitis/synovial proliferation
  • articular/joint pain/arthralgia
  • hypotonia
  • acrocyanosis/raynaud's phenomenon/vasomotor disorders
  • repeat respiratory infections
  • anomalies of eyelids, eyelashes and lacrimal system

Drugs & Therapeutics for Dermatomyositis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Dermatomyositis

Search NIH Clinical Center for Dermatomyositis

Genetic Tests for Dermatomyositis

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Anatomical Context for Dermatomyositis

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Dermatomyositis:

33
Skin, Lung, Heart, Breast, T cells, Bone, Ovary, Testes, Thyroid, Monocytes, B cells, Endothelial, Tongue, Colon, Skeletal muscle, Prostate, Appendix, Brain, Liver, Myeloid

FMA organs/tissues related to Dermatomyositis:

14
Muscle or

Animal Models for Dermatomyositis or affiliated genes

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Publications for Dermatomyositis

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Sources:
52PubMed
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Articles related to Dermatomyositis:

(show top 50)    (show all 1007)
idTitleAuthorsYear
1
Anti-CADM-140/MDA5 autoantibody titer correlates with disease activity and predicts disease outcome in patients with dermatomyositis and rapidly progressive interstitial lung disease. (22644102)
2013
2
Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebo-phase trial. (23124935)
2013
3
Gemcitabine-induced radiation recall myositis in a patient with dermatomyositis. (24283707)
2013
4
Molecular profiling to diagnose a case of atypical dermatomyositis. (23732751)
2013
5
Low prevalence of anti-DFS70/LEDGF antibodies in patients with dermatomyositis and other systemic autoimmune rheumatic diseases. (23280167)
2013
6
Marked increase in serum KL-6 and surfactant proteinA D levels during the first 4A weeks after treatment predicts poor prognosis in patients with active interstitial pneumonia associated with polymyositis/dermatomyositis. (22983659)
2013
7
Mycophenolate mofetil therapy for rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis. (23615839)
2013
8
Age at onset and gender distribution of systemic lupus erythematosus, polymyositis/dermatomyositis, and systemic sclerosis in Japan. (22903259)
2013
9
Hydroxyurea-induced dermatomyositis: true amyopathic dermatomyositis or dermatomyositis-like eruption? (22515579)
2012
10
Design of the muscles in motion study: a randomized controlled trial to evaluate the efficacy and feasibility of an individually tailored home-based exercise training program for children and adolescents with juvenile dermatomyositis. (22721424)
2012
11
Anti-TIF1I^ antibodies (anti-p155) in adult patients with dermatomyositis: comparison of different diagnostic assays. (22294626)
2012
12
Pneumomediastinum and massive subcutaneous emphysema associated with dermatomyositis. (23257541)
2012
13
Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. (22284862)
2012
14
Is dermatomyositis in patients with rheumatoid arthritis induced by anti-TNF-I+ therapy? (21221687)
2011
15
Cytomegalovirus-associated gastric ulcers in a patient with dermatomyositis treated with steroid and cyclophosphamide pulse therapy. (21915824)
2011
16
Comparison of clinical features and drug therapies among European and Latin American patients with juvenile dermatomyositis. (21345298)
2011
17
Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis. (21947177)
2011
18
The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody. (20015976)
2010
19
Reversed halo sign associated with dermatomyositis. (20686316)
2010
20
Juvenile-onset clinically amyopathic dermatomyositis: an overview of recent progress in diagnosis and management. (20034339)
2010
21
Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis. (18821695)
2008
22
Fine-needle aspiration biopsy cytology of cutaneous calcinosis in a 74-year-old woman with dermatomyositis on methotrexate therapy: a case report. (18702364)
2008
23
Bone mineral apparent density in juvenile dermatomyositis: the role of lean body mass and glucocorticoid use. (18189194)
2008
24
Disease-specific quality indicators, outcome measures and guidelines in polymyositis and dermatomyositis. (18021522)
2007
25
Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis. (17469160)
2007
26
Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis. (17938031)
2007
27
Dermatomyositis, lobar panniculitis and inflammatory myopathy with abundant macrophages. (16809038)
2006
28
Genetically determined imbalance between serum levels of tumour necrosis factor (TNF) and interleukin (IL)-10 is associated with anti-Jo-1 and anti-Ro52 autoantibodies in patients with poly- and dermatomyositis. (16895750)
2006
29
Increased Fas and Bcl-2 expression on peripheral blood T and B lymphocytes from juvenile-onset systemic lupus erythematosus, but not from juvenile rheumatoid arthritis and juvenile dermatomyositis. (17162369)
2006
30
Identification of autoantibodies elicited in a patient with prostate cancer presenting as dermatomyositis. (16643611)
2006
31
Use of etanercept in the treatment of dermatomyositis: a case series. (16960940)
2006
32
Diagnostic significance of membrane attack complex and vitronectin in childhood dermatomyositis. (16159528)
2005
33
Intravenous cyclophosphamide pulse therapy in juvenile dermatomyositis. A review of efficacy and safety. (14722349)
2004
34
Update on juvenile dermatomyositis: new advances in understanding its etiopathogenesis. (12960487)
2003
35
Juvenile dermatomyositis associated with lipodystrophy. (17642934)
2003
36
Parathyroid hormone-related protein production by adenocarcinoma in Barrett's esophagus patient with dermatomyositis. (11478513)
2001
37
Amyopathic dermatomyositis in children: a diagnostic and therapeutic dilemma. (17039128)
2001
38
Aerobic capacity in adult dermatomyositis/polymyositis patients and healthy controls. (10638867)
2000
39
Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. (11055823)
2000
40
Dystrophic calcification in adult dermatomyositis: neuroimage. (11146618)
2000
41
Pneumatosis cystoides intestinalis in a patient with dermatomyositis. (10615280)
1999
42
Benefit of 6 months long-term physical training in polymyositis/dermatomyositis patients. (9973161)
1998
43
Germ cell cancer and dermatomyositis. (9543617)
1998
44
Low-dose methotrexate as an adjunctive therapy with surgery for ectropion complicating dermatomyositis. (8829501)
1996
45
Amyopathic dermatomyositis. (7492141)
1995
46
Hypertrichosis in juvenile dermatomyositis. (8034810)
1994
47
Relationship of cancer to inflammatory muscle diseases. Dermatomyositis, polymyositis, and inclusion body myositis. (7855330)
1994
48
Severe secondary amyloidosis in a dog with dermatomyositis. (2474585)
1989
49
Early ultrastructural alterations in adult dermatomyositis. Capillary abnormalities precede other structural changes in muscle. (2614466)
1989
50
Membranous glomerulonephritis, dermatomyositis, and bronchial carcinoma. (227526)
1979

Variations for Dermatomyositis

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Expression for genes affiliated with Dermatomyositis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dermatomyositis

Search GEO for disease gene expression data for Dermatomyositis.

Pathways for genes affiliated with Dermatomyositis

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 60Thomson Reuters, 55Reactome
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Compounds for genes affiliated with Dermatomyositis

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Dermatomyositis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1anticodon4510.2KARS, GARS
2tetramethylpyrazine4510.1ICAM1, CHKB
3sodium cromoglycate4510.1ICAM1, VCAM1
4loratadine45 24 1112.1ICAM1, VCAM1
58 methoxypsoralen4510.1ICAM1, VCAM1
6aminoacyl-trna4510.0KARS, IARS, GARS
7sele4510.0VCAM1, ICAM1
8trna4510.0GARS, IARS, KARS
9helenalin4510.0ICAM1, VCAM1
10hcec4510.0VCAM1, ICAM1
11gliclazide45 51 1112.0VCAM1, ICAM1
12cuprophan4510.0ICAM1, VCAM1
13slex459.9VCAM1, ICAM1
14mycophenolic acid45 51 1111.9ICAM1, VCAM1
15apocynin45 6110.9ICAM1, VCAM1
16hydroxylysine459.9CHKB, SFTPD
17polymyxin b459.9VCAM1, ICAM1
18fluvastatin45 51 29 1112.8ICAM1, CHKB, VCAM1
19Adenosine monophosphate24 1110.8HARS, KARS, IARS, GARS
20phosphoric acid45 2410.8HARS, KARS, IARS, GARS
21pyrophosphate45 2410.8HARS, KARS, IARS, GARS
22pravastatin45 51 29 24 1113.8VCAM1, CHKB, ICAM1
23atorvastatin45 51 29 24 1113.7VCAM1, CHKB, ICAM1
24thenoyltrifluoroacetone45 1110.7SDHB, VCAM1
25okt3459.7ICAM1, VCAM1
26simvastatin45 51 61 29 24 1114.7VCAM1, CHKB, ICAM1
27beta-hydroxybutyrate459.7SDHB, CHKB
28groalpha459.6ICAM1, VCAM1
29triptolide459.5CCR7, ICAM1
30prednisolone45 29 1111.5SFTPD, VCAM1, CHKB
31budesonide45 51 1111.5ICAM1, VCAM1, SFTPD
32gssg459.5SDHB, CHKB
33Adenosine triphosphate24 1110.4HARS, KARS, CHKB, IARS, GARS
34rantes459.4VCAM1, ICAM1, CCR7
35leucine459.3SFTPD, KARS, CHKB, GARS
36matrigel459.2VCAM1, ICAM1, CCR7
37pge2459.2CCR7, ICAM1, CHKB, VCAM1
38endotoxin459.2SFTPD, VCAM1, CHKB, ICAM1
39polysaccharide459.1SFTPD, VCAM1, CHKB, ICAM1
40mannitol45 1110.0ICAM1, CHKB, VCAM1, SDHB
41norepinephrine45 24 1110.8SDHB, VCAM1, CHKB, CCR7
42aspartate458.8HLA-DQA1, SDHB, VCAM1, CHKB
43cholesterol45 29 24 1111.6CHKB, VCAM1, SDHB, SFTPD
44arginine458.6HLA-DQA1, KARS, SDHB, VCAM1, CHKB
45dexamethasone45 51 29 1111.4SFTPD, VCAM1, CHKB, ICAM1
46lactate458.3SFTPD, SDHB, VCAM1, CHKB, ICAM1
47alanine458.3KARS, SDHB, VCAM1, CHKB, CCR7, GARS
48oxygen45 249.3SFTPD, SDHB, VCAM1, CHKB, ICAM1
49cysteine458.2SFTPD, KARS, SDHB, VCAM1, CHKB, GARS
50calcium45 51 24 1110.7GARS, CCR7, CHKB, SDHB, KARS, SFTPD

GO Terms for genes affiliated with Dermatomyositis

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Sources:
16Gene Ontology
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Cellular components related to Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CCR7, ICAM1, VCAM1
2cytosolGO:0058298.7GARS, IFIH1, IARS, CHKB, KARS, HARS

Biological processes related to Dermatomyositis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1diadenosine tetraphosphate biosynthetic processGO:01596610.1GARS, KARS
2membrane to membrane dockingGO:0226149.9VCAM1, ICAM1
3leukocyte cell-cell adhesionGO:0071599.8ICAM1, VCAM1
4heterophilic cell-cell adhesionGO:0071579.8VCAM1, ICAM1
5response to ionizing radiationGO:0102129.7ICAM1, VCAM1
6cellular response to glucose stimulusGO:0713339.6ICAM1, VCAM1
7tRNA aminoacylation for protein translationGO:0064189.6GARS, IARS, KARS, HARS
8interferon-gamma-mediated signaling pathwayGO:0603339.4HLA-DQA1, VCAM1, ICAM1
9gene expressionGO:0104679.3HARS, KARS, IARS, GARS
10cytokine-mediated signaling pathwayGO:0192219.3ICAM1, VCAM1, HLA-DQA1
11positive regulation of actin filament polymerizationGO:0308389.2CCR7, ICAM1

Molecular functions related to Dermatomyositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1helicase activityGO:00438610.0IFIH1, CHD3
2ATP bindingGO:0055248.2GARS, IFIH1, IARS, CHD3, CHKB, KARS

Products for genes affiliated with Dermatomyositis

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  • Antibodies
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Sources for Dermatomyositis

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet