MCID: DRM003
MIFTS: 31

Dermatosis Papulosa Nigra malady

Skin diseases category
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Summaries for Dermatosis Papulosa Nigra

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Sources:
65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Dermatosis papulosa nigra (DPN) is a condition of many small, benign skin lesions on the face, a... more...

MalaCards: Dermatosis Papulosa Nigra is related to keratosis and blindness. An important gene associated with Dermatosis Papulosa Nigra is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Ras signaling pathway and MicroRNAs in cancer. The compounds imatinib and phosphotyrosine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotype tumorigenesis.

Description from OMIM:47 125600

Aliases & Classifications for Dermatosis Papulosa Nigra

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Sources:
8Disease Ontology, 62UMLS, 40NCIt, 58SNOMED-CT, 47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

dermatosis papulosa nigra 8 62


External Ids:

Disease Ontology8 DOID:4400
NCIt40 C2984
OMIM47 125600

Related Diseases for Dermatosis Papulosa Nigra

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Dermatosis Papulosa Nigra:



Diseases related to dermatosis papulosa nigra

Symptoms for Dermatosis Papulosa Nigra

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47OMIM
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Clinical features from OMIM:

125600

Drugs & Therapeutics for Dermatosis Papulosa Nigra

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Dermatosis Papulosa Nigra

Search NIH Clinical Center for Dermatosis Papulosa Nigra

Genetic Tests for Dermatosis Papulosa Nigra

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Anatomical Context for Dermatosis Papulosa Nigra

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33MalaCards
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MalaCards organs/tissues related to Dermatosis Papulosa Nigra:

33
Skin

Animal Models for Dermatosis Papulosa Nigra or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Dermatosis Papulosa Nigra:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1FGFR3, PIK3CA

Publications for Dermatosis Papulosa Nigra

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52PubMed
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Articles related to Dermatosis Papulosa Nigra:

(show all 18)
idTitleAuthorsYear
1
Dermatosis Papulosa Nigra and 10,600-nm CO2 laser, a good choice. (24131098)
2013
2
Postprocedural wound-healing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: a comparison of a skin protectant ointment and a topical antibiotic. (21247663)
2011
3
Clinical features and treatment of dermatosis papulosa nigra in migrants to Italy. (21137605)
2010
4
FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. (19845664)
2010
5
Treatment of dermatosis papulosa nigra in 10 patients: a comparison trial of electrodesiccation, pulsed dye laser, and curettage. (21040130)
2010
6
Comparison of electrodesiccation and potassium-titanyl-phosphate laser for treatment of dermatosis papulosa nigra. (19469798)
2009
7
Dermatosis papulosa nigra treatment with fractional photothermolysis. (19796255)
2009
8
Treatment of dermatosis papulosa nigra with a 1064 nm Nd:YAG laser: report of two cases. (18569266)
2008
9
Dermatosis papulosa nigra in Dakar, Senegal. (17919208)
2007
10
Eruptive dermatosis papulosa nigra as a possible sign of internal malignancy. (17269973)
2007
11
A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra. (16393591)
2006
12
Dermatosis papulosa nigra in a young child. (8302739)
1993
13
A surgical approach for dermatosis papulosa nigra. (6229500)
1983
14
Dermatosis papulosa nigra. (6226495)
1983
15
Dermatosis papulosa nigra and seborrheic keratoses: clinical aspects. (7386792)
1980
16
Dermatosis papulosa nigra. (5662294)
1968
17
DERMATOSIS PAPULOSA NIGRA. (14122095)
1964
18
A case for diagnosis [dermatosis papulosa nigra?]. (18101154)
1948

Variations for Dermatosis Papulosa Nigra

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Expression for genes affiliated with Dermatosis Papulosa Nigra

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dermatosis Papulosa Nigra

Search GEO for disease gene expression data for Dermatosis Papulosa Nigra.

Pathways for genes affiliated with Dermatosis Papulosa Nigra

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Sources:
50PathCards, 30KEGG, 55Reactome, 38NCBI BioSystems Database, 51PharmGKB, 61Tocris Bioscience, 60Thomson Reuters
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Pathways related to Dermatosis Papulosa Nigra according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1FGFR3, PIK3CA
29.1FGFR3, PIK3CA
39.1PIK3CA, FGFR3
49.1FGFR3, PIK3CA
5
Show member pathways
9.1FGFR3, PIK3CA
6
Show member pathways
9.1FGFR3, PIK3CA
7
Show member pathways
9.1FGFR3, PIK3CA
8
Show member pathways
9.1PIK3CA, FGFR3
9
Show member pathways
9.1FGFR3, PIK3CA
10
Show member pathways
9.1FGFR3, PIK3CA
11
Show member pathways
9.1PIK3CA, FGFR3
12
Show member pathways
9.1FGFR3, PIK3CA
13
Show member pathways
9.1FGFR3, PIK3CA
14
Show member pathways
Signaling Pathways in Glioblastoma38
9.1FGFR3, PIK3CA
15
Show member pathways
9.1FGFR3, PIK3CA

Compounds for genes affiliated with Dermatosis Papulosa Nigra

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Dermatosis Papulosa Nigra according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1imatinib45 51 1111.4FGFR3, PIK3CA
2phosphotyrosine459.3FGFR3, PIK3CA
3doxorubicin45 51 1111.3PIK3CA, FGFR3
4dexamethasone45 51 29 1112.3FGFR3, PIK3CA
5vegf459.2FGFR3, PIK3CA
6arginine459.2PIK3CA, FGFR3
7threonine459.1FGFR3, PIK3CA
8Adenosine triphosphate24 1110.1FGFR3, PIK3CA
9glutamate459.0FGFR3, PIK3CA
10adp45 29 2410.8FGFR3, PIK3CA

GO Terms for genes affiliated with Dermatosis Papulosa Nigra

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16Gene Ontology
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Biological processes related to Dermatosis Papulosa Nigra according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-mediated signalingGO:0480159.3FGFR3, PIK3CA
2insulin receptor signaling pathwayGO:0082869.2FGFR3, PIK3CA
3fibroblast growth factor receptor signaling pathwayGO:0085439.2FGFR3, PIK3CA
4Fc-epsilon receptor signaling pathwayGO:0380959.1PIK3CA, FGFR3
5innate immune responseGO:0450879.1FGFR3, PIK3CA
6epidermal growth factor receptor signaling pathwayGO:0071739.0FGFR3, PIK3CA
7neurotrophin TRK receptor signaling pathwayGO:0480118.8FGFR3, PIK3CA

Products for genes affiliated with Dermatosis Papulosa Nigra

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  • Antibodies
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Sources for Dermatosis Papulosa Nigra

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet