MCID: DRM003
MIFTS: 31

Dermatosis Papulosa Nigra malady

Skin diseases category

Summaries for Dermatosis Papulosa Nigra

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Sources:
66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Dermatosis papulosa nigra (DPN) is a condition of many small, benign skin lesions on the face, a... more...

MalaCards: Dermatosis Papulosa Nigra is related to keratosis and blindness. An important gene associated with Dermatosis Papulosa Nigra is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Ras signaling pathway and MicroRNAs in cancer. The compounds imatinib and phosphotyrosine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotype tumorigenesis.

Description from OMIM:48 125600

Aliases & Classifications for Dermatosis Papulosa Nigra

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Sources:
9Disease Ontology, 63UMLS, 41NCIt, 59SNOMED-CT, 48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

dermatosis papulosa nigra 9 63


External Ids:

Disease Ontology9 DOID:4400
NCIt41 C2984
OMIM48 125600

Related Diseases for Dermatosis Papulosa Nigra

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of diseases related to Dermatosis Papulosa Nigra:



Diseases related to dermatosis papulosa nigra

Symptoms for Dermatosis Papulosa Nigra

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48OMIM
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Clinical features from OMIM:

125600

Drugs & Therapeutics for Dermatosis Papulosa Nigra

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Dermatosis Papulosa Nigra

Drug clinical trials:

Search ClinicalTrials for Dermatosis Papulosa Nigra

Search NIH Clinical Center for Dermatosis Papulosa Nigra

Search CenterWatch for Dermatosis Papulosa Nigra

Genetic Tests for Dermatosis Papulosa Nigra

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Anatomical Context for Dermatosis Papulosa Nigra

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34MalaCards
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MalaCards organs/tissues related to Dermatosis Papulosa Nigra:

34
Skin

Animal Models for Dermatosis Papulosa Nigra or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Dermatosis Papulosa Nigra:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1FGFR3, PIK3CA

Publications for Dermatosis Papulosa Nigra

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53PubMed
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Articles related to Dermatosis Papulosa Nigra:

(show all 18)
idTitleAuthorsYear
1
Dermatosis Papulosa Nigra and 10,600-nm CO2 laser, a good choice. (24131098)
2013
2
Postprocedural wound-healing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: a comparison of a skin protectant ointment and a topical antibiotic. (21247663)
2011
3
Clinical features and treatment of dermatosis papulosa nigra in migrants to Italy. (21137605)
2010
4
FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. (19845664)
2010
5
Treatment of dermatosis papulosa nigra in 10 patients: a comparison trial of electrodesiccation, pulsed dye laser, and curettage. (21040130)
2010
6
Comparison of electrodesiccation and potassium-titanyl-phosphate laser for treatment of dermatosis papulosa nigra. (19469798)
2009
7
Dermatosis papulosa nigra treatment with fractional photothermolysis. (19796255)
2009
8
Treatment of dermatosis papulosa nigra with a 1064 nm Nd:YAG laser: report of two cases. (18569266)
2008
9
Dermatosis papulosa nigra in Dakar, Senegal. (17919208)
2007
10
Eruptive dermatosis papulosa nigra as a possible sign of internal malignancy. (17269973)
2007
11
A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra. (16393591)
2006
12
Dermatosis papulosa nigra in a young child. (8302739)
1993
13
A surgical approach for dermatosis papulosa nigra. (6229500)
1983
14
Dermatosis papulosa nigra. (6226495)
1983
15
Dermatosis papulosa nigra and seborrheic keratoses: clinical aspects. (7386792)
1980
16
Dermatosis papulosa nigra. (5662294)
1968
17
DERMATOSIS PAPULOSA NIGRA. (14122095)
1964
18
A case for diagnosis [dermatosis papulosa nigra?]. (18101154)
1948

Variations for Dermatosis Papulosa Nigra

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Expression for genes affiliated with Dermatosis Papulosa Nigra

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dermatosis Papulosa Nigra

Search GEO for disease gene expression data for Dermatosis Papulosa Nigra.

Pathways for genes affiliated with Dermatosis Papulosa Nigra

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Sources:
51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 62Tocris Bioscience, 61Thomson Reuters
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Pathways related to Dermatosis Papulosa Nigra according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1FGFR3, PIK3CA
29.1FGFR3, PIK3CA
39.1PIK3CA, FGFR3
49.1FGFR3, PIK3CA
5
Show member pathways
9.1FGFR3, PIK3CA
6
Show member pathways
9.1FGFR3, PIK3CA
7
Show member pathways
9.1FGFR3, PIK3CA
8
Show member pathways
9.1PIK3CA, FGFR3
9
Show member pathways
9.1FGFR3, PIK3CA
10
Show member pathways
9.1FGFR3, PIK3CA
11
Show member pathways
9.1PIK3CA, FGFR3
12
Show member pathways
9.1FGFR3, PIK3CA
13
Show member pathways
9.1FGFR3, PIK3CA
14
Show member pathways
Signaling Pathways in Glioblastoma39
9.1FGFR3, PIK3CA
15
Show member pathways
9.1FGFR3, PIK3CA

Compounds for genes affiliated with Dermatosis Papulosa Nigra

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB
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Compounds related to Dermatosis Papulosa Nigra according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1imatinib46 52 1211.4FGFR3, PIK3CA
2phosphotyrosine469.3FGFR3, PIK3CA
3doxorubicin46 52 1211.3PIK3CA, FGFR3
4dexamethasone46 52 30 1212.3FGFR3, PIK3CA
5vegf469.2FGFR3, PIK3CA
6arginine469.2PIK3CA, FGFR3
7threonine469.1FGFR3, PIK3CA
8Adenosine triphosphate25 1210.1FGFR3, PIK3CA
9glutamate469.0FGFR3, PIK3CA
10adp46 30 2510.8FGFR3, PIK3CA

GO Terms for genes affiliated with Dermatosis Papulosa Nigra

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Sources:
17Gene Ontology
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Biological processes related to Dermatosis Papulosa Nigra according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-mediated signalingGO:0480159.3FGFR3, PIK3CA
2insulin receptor signaling pathwayGO:0082869.2FGFR3, PIK3CA
3fibroblast growth factor receptor signaling pathwayGO:0085439.2FGFR3, PIK3CA
4Fc-epsilon receptor signaling pathwayGO:0380959.1PIK3CA, FGFR3
5innate immune responseGO:0450879.1FGFR3, PIK3CA
6epidermal growth factor receptor signaling pathwayGO:0071739.0FGFR3, PIK3CA
7neurotrophin TRK receptor signaling pathwayGO:0480118.8FGFR3, PIK3CA

Products for genes affiliated with Dermatosis Papulosa Nigra

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  • Antibodies
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Sources for Dermatosis Papulosa Nigra

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet