MCID: DRM003
MIFTS: 32

Dermatosis Papulosa Nigra malady

Categories: Skin diseases

Aliases & Classifications for Dermatosis Papulosa Nigra

Aliases & Descriptions for Dermatosis Papulosa Nigra:

Name: Dermatosis Papulosa Nigra 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4400
ICD10 33 L82
MeSH 42 C562379
NCIt 47 C2984
UMLS 69 C0011645

Summaries for Dermatosis Papulosa Nigra

MalaCards based summary : Dermatosis Papulosa Nigra is related to keratosis and melanocytic nevus syndrome, congenital, somatic, and has symptoms including abnormality of the skin An important gene associated with Dermatosis Papulosa Nigra is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are GAB1 signalosome and Glioma. The drugs Epinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Wikipedia : 71 Dermatosis papulosa nigra (DPN) is a condition of many small, benign skin lesions on the face, a... more...

Related Diseases for Dermatosis Papulosa Nigra

Graphical network of the top 20 diseases related to Dermatosis Papulosa Nigra:



Diseases related to Dermatosis Papulosa Nigra

Symptoms & Phenotypes for Dermatosis Papulosa Nigra

Human phenotypes related to Dermatosis Papulosa Nigra:

32
id Description HPO Frequency HPO Source Accession
1 abnormality of the skin 32 HP:0000951

GenomeRNAi Phenotypes related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.65 FGFR3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.65 PIK3CA
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.65 MTOR
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.65 PIK3CA
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.65 MTOR PIK3CA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.65 FGFR3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.65 FGFR3 MTOR PIK3CA
8 Decreased viability GR00055-A-2 9.64 MTOR PIK3CA
9 Decreased viability GR00221-A-1 9.64 PIK3CA MTOR FGFR3
10 Decreased viability GR00221-A-2 9.64 PIK3CA FGFR3
11 Decreased viability GR00221-A-3 9.64 FGFR3
12 Decreased viability GR00221-A-4 9.64 PIK3CA MTOR
13 Decreased viability GR00342-S-1 9.64 MTOR
14 Decreased viability GR00342-S-2 9.64 MTOR
15 Decreased cell migration GR00055-A-1 9.33 FGFR3 MTOR PIK3CA

Drugs & Therapeutics for Dermatosis Papulosa Nigra

Drugs for Dermatosis Papulosa Nigra (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2
Lidocaine Approved, Vet_approved 137-58-6 3676
3 Anesthetics
4 Epinephryl borate
5 Racepinephrine

Interventional clinical trials:


id Name Status NCT ID Phase
1 Dermatosis Papulosa Nigra Completed NCT00710203

Search NIH Clinical Center for Dermatosis Papulosa Nigra

Cochrane evidence based reviews: dermatosis papulosa nigra

Genetic Tests for Dermatosis Papulosa Nigra

Anatomical Context for Dermatosis Papulosa Nigra

MalaCards organs/tissues related to Dermatosis Papulosa Nigra:

39
Skin

Publications for Dermatosis Papulosa Nigra

Articles related to Dermatosis Papulosa Nigra:

(show all 21)
id Title Authors Year
1
Early-onset dermatosis papulosa nigra. ( 26639606 )
2016
2
Carbon dioxide laser ablation of dermatosis papulosa nigra: high satisfaction and few complications in patients with pigmented skin. ( 26868030 )
2016
3
Effectiveness of the Pulse Dye Laser Treatment in a Caucasian Women With Dermatosis Papulosa Nigra. ( 26120179 )
2015
4
Dermatosis Papulosa Nigra and 10,600-nm CO2 laser, a good choice. ( 24131098 )
2013
5
Postprocedural wound-healing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: a comparison of a skin protectant ointment and a topical antibiotic. ( 21247663 )
2011
6
Treatment of dermatosis papulosa nigra in 10 patients: a comparison trial of electrodesiccation, pulsed dye laser, and curettage. ( 21040130 )
2010
7
FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. ( 19845664 )
2010
8
Clinical features and treatment of dermatosis papulosa nigra in migrants to Italy. ( 21137605 )
2010
9
Dermatosis papulosa nigra treatment with fractional photothermolysis. ( 19796255 )
2009
10
Comparison of electrodesiccation and potassium-titanyl-phosphate laser for treatment of dermatosis papulosa nigra. ( 19469798 )
2009
11
Treatment of dermatosis papulosa nigra with a 1064 nm Nd:YAG laser: report of two cases. ( 18569266 )
2008
12
Dermatosis papulosa nigra in Dakar, Senegal. ( 17919208 )
2007
13
Eruptive dermatosis papulosa nigra as a possible sign of internal malignancy. ( 17269973 )
2007
14
A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra. ( 16393591 )
2006
15
Dermatosis papulosa nigra in a young child. ( 8302739 )
1993
16
A surgical approach for dermatosis papulosa nigra. ( 6229500 )
1983
17
Dermatosis papulosa nigra. ( 6226495 )
1983
18
Dermatosis papulosa nigra and seborrheic keratoses: clinical aspects. ( 7386792 )
1980
19
Dermatosis papulosa nigra. ( 5662294 )
1968
20
DERMATOSIS PAPULOSA NIGRA. ( 14122095 )
1964
21
A case for diagnosis [dermatosis papulosa nigra?]. ( 18101154 )
1948

Variations for Dermatosis Papulosa Nigra

Expression for Dermatosis Papulosa Nigra

Search GEO for disease gene expression data for Dermatosis Papulosa Nigra.

Pathways for Dermatosis Papulosa Nigra

Pathways related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

(show all 35)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 FGFR3 MTOR PIK3CA
2
Show member pathways
12.64 FGFR3 MTOR PIK3CA
3
Show member pathways
12.46 FGFR3 MTOR PIK3CA
4
Show member pathways
12.31 FGFR3 MTOR PIK3CA
5 12.25 FGFR3 MTOR PIK3CA
6 12.11 FGFR3 MTOR PIK3CA
7 11.97 FGFR3 MTOR PIK3CA
8
Show member pathways
11.95 MTOR PIK3CA
9
Show member pathways
11.9 FGFR3 MTOR PIK3CA
10
Show member pathways
11.88 FGFR3 MTOR
11
Show member pathways
11.87 MTOR PIK3CA
12
Show member pathways
11.86 MTOR PIK3CA
13
Show member pathways
11.85 FGFR3 PIK3CA
14
Show member pathways
11.83 MTOR PIK3CA
15
Show member pathways
11.81 MTOR PIK3CA
16 11.79 MTOR PIK3CA
17 11.78 FGFR3 PIK3CA
18
Show member pathways
11.75 FGFR3 MTOR PIK3CA
19 11.73 MTOR PIK3CA
20 11.68 MTOR PIK3CA
21
Show member pathways
11.65 MTOR PIK3CA
22 11.61 MTOR PIK3CA
23 11.59 MTOR PIK3CA
24
Show member pathways
11.57 MTOR PIK3CA
25
Show member pathways
11.53 FGFR3 MTOR PIK3CA
26 11.52 MTOR PIK3CA
27
Show member pathways
11.47 MTOR PIK3CA
28 11.45 MTOR PIK3CA
29 11.42 MTOR PIK3CA
30 11.37 MTOR PIK3CA
31
Show member pathways
11.35 MTOR PIK3CA
32 11.31 MTOR PIK3CA
33 10.96 MTOR PIK3CA
34 10.85 MTOR PIK3CA
35 10.61 FGFR3 MTOR PIK3CA

GO Terms for Dermatosis Papulosa Nigra

Cellular components related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase complex GO:0005942 8.62 MTOR PIK3CA

Biological processes related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.63 FGFR3 MTOR PIK3CA
2 protein phosphorylation GO:0006468 9.61 FGFR3 MTOR PIK3CA
3 phosphatidylinositol phosphorylation GO:0046854 9.48 FGFR3 PIK3CA
4 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.4 FGFR3 PIK3CA
5 T cell costimulation GO:0031295 9.37 MTOR PIK3CA
6 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.32 FGFR3 PIK3CA
7 cardiac muscle contraction GO:0060048 9.26 MTOR PIK3CA
8 negative regulation of macroautophagy GO:0016242 9.16 MTOR PIK3CA
9 anoikis GO:0043276 8.96 MTOR PIK3CA
10 phosphatidylinositol-mediated signaling GO:0048015 8.8 FGFR3 MTOR PIK3CA

Molecular functions related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.33 FGFR3 MTOR PIK3CA
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.96 FGFR3 PIK3CA
3 1-phosphatidylinositol-3-kinase activity GO:0016303 8.62 FGFR3 PIK3CA

Sources for Dermatosis Papulosa Nigra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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