MCID: DRM003
MIFTS: 32

Dermatosis Papulosa Nigra malady

Category: Skin diseases

Aliases & Classifications for Dermatosis Papulosa Nigra

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Aliases & Descriptions for Dermatosis Papulosa Nigra:

Name: Dermatosis Papulosa Nigra 11 13 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:4400
ICD1028 L82
MeSH37 C562379
NCIt43 C2984

Summaries for Dermatosis Papulosa Nigra

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Wikipedia:69 Dermatosis papulosa nigra (DPN) is a condition of many small, benign skin lesions on the face, a... more...

MalaCards based summary: Dermatosis Papulosa Nigra is related to keratosis and pancreatitis, pediatric, and has symptoms including abnormality of the skin An important gene associated with Dermatosis Papulosa Nigra is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways are MAPK Signaling: Mitogen Stimulation Pathway and Regulation of cholesterol biosynthesis by SREBP (SREBF). Affiliated tissues include skin, and related mouse phenotype no phenotypic analysis.

Related Diseases for Dermatosis Papulosa Nigra

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Graphical network of diseases related to Dermatosis Papulosa Nigra:



Diseases related to dermatosis papulosa nigra

Symptoms for Dermatosis Papulosa Nigra

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HPO human phenotypes related to Dermatosis Papulosa Nigra:

id Description Frequency HPO Source Accession
1 abnormality of the skin HP:0000951

Drugs & Therapeutics for Dermatosis Papulosa Nigra

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Drugs for Dermatosis Papulosa Nigra (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Lidocaine1168137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
2
Epinephrine88651-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dermatosis Papulosa NigraCompletedNCT00710203

Search NIH Clinical Center for Dermatosis Papulosa Nigra


Cochrane evidence based reviews: dermatosis papulosa nigra

Genetic Tests for Dermatosis Papulosa Nigra

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Anatomical Context for Dermatosis Papulosa Nigra

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MalaCards organs/tissues related to Dermatosis Papulosa Nigra:

34
Skin

Animal Models for Dermatosis Papulosa Nigra or affiliated genes

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MGI Mouse Phenotypes related to Dermatosis Papulosa Nigra:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8FGFR3, MTOR, PIK3CA

Publications for Dermatosis Papulosa Nigra

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Articles related to Dermatosis Papulosa Nigra:

(show all 21)
idTitleAuthorsYear
1
Carbon dioxide laser ablation of dermatosis papulosa nigra: high satisfaction and few complications in patients with pigmented skin. (26868030)
2016
2
Early-onset dermatosis papulosa nigra. (26639606)
2016
3
Effectiveness of the Pulse Dye Laser Treatment in a Caucasian Women With Dermatosis Papulosa Nigra. (26120179)
2015
4
Dermatosis Papulosa Nigra and 10,600-nm CO2 laser, a good choice. (24131098)
2013
5
Postprocedural wound-healing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: a comparison of a skin protectant ointment and a topical antibiotic. (21247663)
2011
6
FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. (19845664)
2010
7
Clinical features and treatment of dermatosis papulosa nigra in migrants to Italy. (21137605)
2010
8
Treatment of dermatosis papulosa nigra in 10 patients: a comparison trial of electrodesiccation, pulsed dye laser, and curettage. (21040130)
2010
9
Comparison of electrodesiccation and potassium-titanyl-phosphate laser for treatment of dermatosis papulosa nigra. (19469798)
2009
10
Dermatosis papulosa nigra treatment with fractional photothermolysis. (19796255)
2009
11
Treatment of dermatosis papulosa nigra with a 1064 nm Nd:YAG laser: report of two cases. (18569266)
2008
12
Eruptive dermatosis papulosa nigra as a possible sign of internal malignancy. (17269973)
2007
13
Dermatosis papulosa nigra in Dakar, Senegal. (17919208)
2007
14
A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra. (16393591)
2006
15
Dermatosis papulosa nigra in a young child. (8302739)
1993
16
A surgical approach for dermatosis papulosa nigra. (6229500)
1983
17
Dermatosis papulosa nigra. (6226495)
1983
18
Dermatosis papulosa nigra and seborrheic keratoses: clinical aspects. (7386792)
1980
19
Dermatosis papulosa nigra. (5662294)
1968
20
DERMATOSIS PAPULOSA NIGRA. (14122095)
1964
21
A case for diagnosis [dermatosis papulosa nigra?]. (18101154)
1948

Variations for Dermatosis Papulosa Nigra

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Expression for genes affiliated with Dermatosis Papulosa Nigra

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Search GEO for disease gene expression data for Dermatosis Papulosa Nigra.

Pathways for genes affiliated with Dermatosis Papulosa Nigra

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Pathways related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

(show all 42)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.3FGFR3, MTOR
2
Show member pathways
9.1MTOR, PIK3CA
39.1MTOR, PIK3CA
4
Show member pathways
9.1MTOR, PIK3CA
5
Show member pathways
9.1MTOR, PIK3CA
69.1MTOR, PIK3CA
7
Show member pathways
9.1MTOR, PIK3CA
8
Show member pathways
9.1MTOR, PIK3CA
9
Show member pathways
9.1MTOR, PIK3CA
10
Show member pathways
9.1MTOR, PIK3CA
11
Show member pathways
9.1MTOR, PIK3CA
12
Show member pathways
9.1MTOR, PIK3CA
13
Show member pathways
9.1MTOR, PIK3CA
14
Show member pathways
9.1MTOR, PIK3CA
159.1MTOR, PIK3CA
16
Show member pathways
9.1MTOR, PIK3CA
17
Show member pathways
9.1MTOR, PIK3CA
189.1MTOR, PIK3CA
199.1MTOR, PIK3CA
209.1MTOR, PIK3CA
219.1MTOR, PIK3CA
229.1MTOR, PIK3CA
239.1MTOR, PIK3CA
24
Show member pathways
9.1MTOR, PIK3CA
259.1MTOR, PIK3CA
26
Show member pathways
9.1MTOR, PIK3CA
27
Show member pathways
9.1MTOR, PIK3CA
289.1MTOR, PIK3CA
29
Show member pathways
9.0FGFR3, PIK3CA
309.0FGFR3, PIK3CA
31
Show member pathways
9.0FGFR3, PIK3CA
328.5FGFR3, MTOR, PIK3CA
33
Show member pathways
8.5FGFR3, MTOR, PIK3CA
34
Show member pathways
8.5FGFR3, MTOR, PIK3CA
35
Show member pathways
8.5FGFR3, MTOR, PIK3CA
368.5FGFR3, MTOR, PIK3CA
37
Show member pathways
8.5FGFR3, MTOR, PIK3CA
388.5FGFR3, MTOR, PIK3CA
39
Show member pathways
8.5FGFR3, MTOR, PIK3CA
408.5FGFR3, MTOR, PIK3CA
41
Show member pathways
8.5FGFR3, MTOR, PIK3CA
42
Show member pathways
8.5FGFR3, MTOR, PIK3CA

GO Terms for genes affiliated with Dermatosis Papulosa Nigra

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Cellular components related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol 3-kinase complexGO:00059429.1MTOR, PIK3CA

Biological processes related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-3-phosphate biosynthetic processGO:00360929.5FGFR3, PIK3CA
2phosphatidylinositol phosphorylationGO:00468549.4FGFR3, PIK3CA
3regulation of phosphatidylinositol 3-kinase signalingGO:00140669.4FGFR3, PIK3CA
4protein autophosphorylationGO:00467779.2FGFR3, MTOR
5T cell costimulationGO:00312959.1MTOR, PIK3CA
6cardiac muscle contractionGO:00600488.8MTOR, PIK3CA
7phosphatidylinositol-mediated signalingGO:00480158.8FGFR3, MTOR, PIK3CA

Molecular functions related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
11-phosphatidylinositol-3-kinase activityGO:00163039.7FGFR3, PIK3CA
2kinase activityGO:00163019.6MTOR, PIK3CA
3phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.6FGFR3, PIK3CA
4ATP bindingGO:00055248.5FGFR3, MTOR, PIK3CA

Sources for Dermatosis Papulosa Nigra

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet