MCID: DRM003
MIFTS: 25

Dermatosis Papulosa Nigra malady

Summaries for Dermatosis Papulosa Nigra

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Sources:
63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Dermatosis papulosa nigra (DPN) is a condition of many small, benign skin lesions on the face, a... more...

MalaCards: Dermatosis Papulosa Nigra is related to keratosis and endometrial carcinoma. An important gene associated with Dermatosis Papulosa Nigra is FGFR3 (fibroblast growth factor receptor 3), and among its related pathways are Regulation of Actin Cytoskeleton and Fc epsilon receptor (FCERI) signaling. The compounds doxorubicin and imatinib have been mentioned in the context of this disorder. Affiliated tissues include skin.

Description from OMIM:46 125600

Aliases & Classifications for Dermatosis Papulosa Nigra

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 46OMIM
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Aliases & Descriptions:

dermatosis papulosa nigra 8 60


External Ids:

Disease Ontology8 DOID:4400
NCIt39 C2984
OMIM46 125600

Related Diseases for Dermatosis Papulosa Nigra

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17GeneCards, 18GeneDecks
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Diseases related to Dermatosis Papulosa Nigra via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1keratosis10.4
2endometrial carcinoma10.0PIK3CA
3bladder carcinoma10.0FGFR3
4seborrheic keratosis10.0FGFR3, PIK3CA
5colorectal cancer, somatic10.0FGFR3, PIK3CA
6thyroid cancer10.0FGFR3, PIK3CA
7cervical cancer10.0FGFR3, PIK3CA
8hypertrophy of breast10.0FGFR3, PIK3CA
9colorectal cancer10.0PIK3CA, FGFR3

Graphical network of diseases related to Dermatosis Papulosa Nigra:



Diseases related to dermatosis papulosa nigra

Clinical Features for Dermatosis Papulosa Nigra

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46OMIM
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Clinical features from OMIM:

125600

Drugs & Therapeutics for Dermatosis Papulosa Nigra

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Dermatosis Papulosa Nigra

Drug clinical trials:

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Search NIH Clinical Center for Dermatosis Papulosa Nigra

Search CenterWatch for Dermatosis Papulosa Nigra

Genetic Tests for Dermatosis Papulosa Nigra

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Anatomical Context for Dermatosis Papulosa Nigra

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32MalaCards
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MalaCards organs/tissues related to Dermatosis Papulosa Nigra:

32
Skin

Animal Models for Dermatosis Papulosa Nigra or affiliated genes

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Publications for Dermatosis Papulosa Nigra

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50PubMed
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Articles related to Dermatosis Papulosa Nigra:

(show all 18)
idTitleAuthorsYear
1
Dermatosis Papulosa Nigra and 10,600-nm CO2 laser, a good choice. (24131098)
2013
2
Postprocedural wound-healing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: a comparison of a skin protectant ointment and a topical antibiotic. (21247663)
2011
3
Clinical features and treatment of dermatosis papulosa nigra in migrants to Italy. (21137605)
2010
4
FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. (19845664)
2010
5
Treatment of dermatosis papulosa nigra in 10 patients: a comparison trial of electrodesiccation, pulsed dye laser, and curettage. (21040130)
2010
6
Comparison of electrodesiccation and potassium-titanyl-phosphate laser for treatment of dermatosis papulosa nigra. (19469798)
2009
7
Dermatosis papulosa nigra treatment with fractional photothermolysis. (19796255)
2009
8
Treatment of dermatosis papulosa nigra with a 1064 nm Nd:YAG laser: report of two cases. (18569266)
2008
9
Dermatosis papulosa nigra in Dakar, Senegal. (17919208)
2007
10
Eruptive dermatosis papulosa nigra as a possible sign of internal malignancy. (17269973)
2007
11
A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra. (16393591)
2006
12
Dermatosis papulosa nigra in a young child. (8302739)
1993
13
A surgical approach for dermatosis papulosa nigra. (6229500)
1983
14
Dermatosis papulosa nigra. (6226495)
1983
15
Dermatosis papulosa nigra and seborrheic keratoses: clinical aspects. (7386792)
1980
16
Dermatosis papulosa nigra. (5662294)
1968
17
DERMATOSIS PAPULOSA NIGRA. (14122095)
1964
18
A case for diagnosis [dermatosis papulosa nigra?]. (18101154)
1948

Genetic Variations for Dermatosis Papulosa Nigra

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Expression for genes affiliated with Dermatosis Papulosa Nigra

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dermatosis Papulosa Nigra

Search GEO for disease gene expression data for Dermatosis Papulosa Nigra.

Pathways for genes affiliated with Dermatosis Papulosa Nigra

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 49PharmGKB, 59Tocris Bioscience, 51QIAGEN, 12EMD Millipore
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Pathways related to Dermatosis Papulosa Nigra according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1FGFR3, PIK3CA
2
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9.1FGFR3, PIK3CA
39.1PIK3CA, FGFR3
49.1FGFR3, PIK3CA
5
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9.1FGFR3, PIK3CA
69.1FGFR3, PIK3CA
7
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9.1PIK3CA, FGFR3
8
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9.1FGFR3, PIK3CA
9
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9.1FGFR3, PIK3CA
10
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9.1FGFR3, PIK3CA
11
Development FGF-family signaling
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9.1PIK3CA, FGFR3
12
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9.1FGFR3, PIK3CA
13
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9.1FGFR3, PIK3CA
14
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9.1FGFR3, PIK3CA

Compounds for genes affiliated with Dermatosis Papulosa Nigra

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Dermatosis Papulosa Nigra according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1doxorubicin44 49 1111.1FGFR3, PIK3CA
2imatinib44 49 1111.0FGFR3, PIK3CA
3phosphotyrosine448.8FGFR3, PIK3CA

GO Terms for genes affiliated with Dermatosis Papulosa Nigra

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16Gene Ontology
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Biological processes related to Dermatosis Papulosa Nigra according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-mediated signalingGO:0480159.3FGFR3, PIK3CA
2insulin receptor signaling pathwayGO:0082869.2FGFR3, PIK3CA
3fibroblast growth factor receptor signaling pathwayGO:0085439.2FGFR3, PIK3CA
4Fc-epsilon receptor signaling pathwayGO:0380959.1PIK3CA, FGFR3
5innate immune responseGO:0450879.1FGFR3, PIK3CA
6epidermal growth factor receptor signaling pathwayGO:0071739.0FGFR3, PIK3CA
7neurotrophin TRK receptor signaling pathwayGO:0480118.8FGFR3, PIK3CA

Products for genes affiliated with Dermatosis Papulosa Nigra

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dermatosis Papulosa Nigra

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet