Aliases & Classifications for Dermatosis Papulosa Nigra

MalaCards integrated aliases for Dermatosis Papulosa Nigra:

Name: Dermatosis Papulosa Nigra 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4400
ICD10 33 L82
MeSH 42 C562379
NCIt 47 C2984
SNOMED-CT via HPO 65 199879009 95320005
UMLS 69 C0011645

Summaries for Dermatosis Papulosa Nigra

MalaCards based summary : Dermatosis Papulosa Nigra is related to keratosis and papular mucinosis, and has symptoms including abnormality of the skin An important gene associated with Dermatosis Papulosa Nigra is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and NFAT and Cardiac Hypertrophy. The drugs Pharmaceutical Solutions and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and no phenotypic analysis

Wikipedia : 72 Dermatosis papulosa nigra (DPN) is a condition of many small, benign skin lesions on the face, a... more...

Related Diseases for Dermatosis Papulosa Nigra

Graphical network of the top 20 diseases related to Dermatosis Papulosa Nigra:



Diseases related to Dermatosis Papulosa Nigra

Symptoms & Phenotypes for Dermatosis Papulosa Nigra

Human phenotypes related to Dermatosis Papulosa Nigra:

32
id Description HPO Frequency HPO Source Accession
1 abnormality of the skin 32 HP:0000951

GenomeRNAi Phenotypes related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.65 FGFR3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.65 PIK3CA
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.65 MTOR
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.65 PIK3CA
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.65 MTOR PIK3CA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.65 FGFR3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.65 FGFR3 MTOR PIK3CA
8 Decreased viability GR00055-A-2 9.64 MTOR PIK3CA
9 Decreased viability GR00221-A-1 9.64 FGFR3 MTOR PIK3CA
10 Decreased viability GR00221-A-2 9.64 FGFR3 PIK3CA
11 Decreased viability GR00221-A-3 9.64 FGFR3
12 Decreased viability GR00221-A-4 9.64 MTOR PIK3CA
13 Decreased viability GR00342-S-1 9.64 MTOR
14 Decreased viability GR00342-S-2 9.64 MTOR
15 Decreased cell migration GR00055-A-1 9.33 FGFR3 MTOR PIK3CA

MGI Mouse Phenotypes related to Dermatosis Papulosa Nigra:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.8 FGFR3 MTOR PIK3CA

Drugs & Therapeutics for Dermatosis Papulosa Nigra

Drugs for Dermatosis Papulosa Nigra (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2
2
Epinephrine Approved, Vet_approved 51-43-4 5816
3
Lidocaine Approved, Vet_approved 137-58-6 3676
4 Racepinephrine Approved
5 Anesthetics
6 Epinephryl borate

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Study of A-101 Topical Solution in Subjects With Dermatosis Papulosa Nigra Recruiting NCT03224598 Phase 2 A-101 Topical Solution 40%
2 Dermatosis Papulosa Nigra Completed NCT00710203

Search NIH Clinical Center for Dermatosis Papulosa Nigra

Cochrane evidence based reviews: dermatosis papulosa nigra

Genetic Tests for Dermatosis Papulosa Nigra

Anatomical Context for Dermatosis Papulosa Nigra

MalaCards organs/tissues related to Dermatosis Papulosa Nigra:

39
Skin

Publications for Dermatosis Papulosa Nigra

Articles related to Dermatosis Papulosa Nigra:

(show all 24)
id Title Authors Year
1
A clinical, dermoscopic, and histopathological study of Dermatosis Papulosa Nigra (DPN) - An Indian perspective. ( 28485013 )
2017
2
Dermatosis papulosa nigra: a clinically and histopathologically distinct entity. ( 28916031 )
2017
3
First case of dermatosis papulosa nigra in a white child. ( 28846142 )
2017
4
Carbon dioxide laser ablation of dermatosis papulosa nigra: high satisfaction and few complications in patients with pigmented skin. ( 26868030 )
2016
5
Early-onset dermatosis papulosa nigra. ( 26639606 )
2016
6
Effectiveness of the Pulse Dye Laser Treatment in a Caucasian Women With Dermatosis Papulosa Nigra. ( 26120179 )
2015
7
Dermatosis Papulosa Nigra and 10,600-nm CO2 laser, a good choice. ( 24131098 )
2013
8
Postprocedural wound-healing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: a comparison of a skin protectant ointment and a topical antibiotic. ( 21247663 )
2011
9
FGFR3 and PIK3CA mutations in stucco keratosis and dermatosis papulosa nigra. ( 19845664 )
2010
10
Clinical features and treatment of dermatosis papulosa nigra in migrants to Italy. ( 21137605 )
2010
11
Treatment of dermatosis papulosa nigra in 10 patients: a comparison trial of electrodesiccation, pulsed dye laser, and curettage. ( 21040130 )
2010
12
Dermatosis papulosa nigra treatment with fractional photothermolysis. ( 19796255 )
2009
13
Comparison of electrodesiccation and potassium-titanyl-phosphate laser for treatment of dermatosis papulosa nigra. ( 19469798 )
2009
14
Treatment of dermatosis papulosa nigra with a 1064 nm Nd:YAG laser: report of two cases. ( 18569266 )
2008
15
Eruptive dermatosis papulosa nigra as a possible sign of internal malignancy. ( 17269973 )
2007
16
Dermatosis papulosa nigra in Dakar, Senegal. ( 17919208 )
2007
17
A randomized, double-blind comparison of two topical anesthetic formulations prior to electrodesiccation of dermatosis papulosa nigra. ( 16393591 )
2006
18
Dermatosis papulosa nigra in a young child. ( 8302739 )
1993
19
A surgical approach for dermatosis papulosa nigra. ( 6229500 )
1983
20
Dermatosis papulosa nigra. ( 6226495 )
1983
21
Dermatosis papulosa nigra and seborrheic keratoses: clinical aspects. ( 7386792 )
1980
22
Dermatosis papulosa nigra. ( 5662294 )
1968
23
DERMATOSIS PAPULOSA NIGRA. ( 14122095 )
1964
24
A case for diagnosis [dermatosis papulosa nigra?]. ( 18101154 )
1948

Variations for Dermatosis Papulosa Nigra

Expression for Dermatosis Papulosa Nigra

Search GEO for disease gene expression data for Dermatosis Papulosa Nigra.

Pathways for Dermatosis Papulosa Nigra

Pathways related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

(show all 42)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 FGFR3 MTOR PIK3CA
2
Show member pathways
12.43 FGFR3 MTOR PIK3CA
3
Show member pathways
12.29 FGFR3 MTOR PIK3CA
4 12.25 FGFR3 MTOR PIK3CA
5 12.18 FGFR3 MTOR PIK3CA
6
Show member pathways
12.14 FGFR3 MTOR PIK3CA
7
Show member pathways
12.04 MTOR PIK3CA
8 12.02 FGFR3 MTOR PIK3CA
9
Show member pathways
12.01 MTOR PIK3CA
10
Show member pathways
12 MTOR PIK3CA
11 11.98 MTOR PIK3CA
12
Show member pathways
11.96 FGFR3 PIK3CA
13
Show member pathways
11.95 MTOR PIK3CA
14
Show member pathways
11.9 MTOR PIK3CA
15
Show member pathways
11.9 MTOR PIK3CA
16
Show member pathways
11.9 FGFR3 MTOR PIK3CA
17
Show member pathways
11.87 MTOR PIK3CA
18
Show member pathways
11.86 MTOR PIK3CA
19
Show member pathways
11.85 FGFR3 PIK3CA
20
Show member pathways
11.82 MTOR PIK3CA
21
Show member pathways
11.82 MTOR PIK3CA
22
Show member pathways
11.8 MTOR PIK3CA
23 11.77 FGFR3 PIK3CA
24
Show member pathways
11.75 FGFR3 MTOR PIK3CA
25 11.73 MTOR PIK3CA
26
Show member pathways
11.71 FGFR3 MTOR PIK3CA
27 11.68 MTOR PIK3CA
28
Show member pathways
11.65 MTOR PIK3CA
29 11.61 MTOR PIK3CA
30 11.59 MTOR PIK3CA
31 11.58 MTOR PIK3CA
32
Show member pathways
11.57 MTOR PIK3CA
33
Show member pathways
11.53 FGFR3 MTOR PIK3CA
34
Show member pathways
11.51 MTOR PIK3CA
35 11.46 MTOR PIK3CA
36 11.43 MTOR PIK3CA
37 11.39 MTOR PIK3CA
38
Show member pathways
11.37 MTOR PIK3CA
39 11.32 MTOR PIK3CA
40 10.99 MTOR PIK3CA
41 10.91 MTOR PIK3CA
42 10.61 FGFR3 MTOR PIK3CA

GO Terms for Dermatosis Papulosa Nigra

Cellular components related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase complex GO:0005942 8.62 MTOR PIK3CA

Biological processes related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.58 FGFR3 MTOR PIK3CA
2 protein phosphorylation GO:0006468 9.54 FGFR3 MTOR PIK3CA
3 protein autophosphorylation GO:0046777 9.49 FGFR3 MTOR
4 phosphatidylinositol phosphorylation GO:0046854 9.48 FGFR3 PIK3CA
5 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.46 FGFR3 PIK3CA
6 T cell costimulation GO:0031295 9.43 MTOR PIK3CA
7 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.32 FGFR3 PIK3CA
8 cardiac muscle contraction GO:0060048 9.26 MTOR PIK3CA
9 negative regulation of macroautophagy GO:0016242 9.16 MTOR PIK3CA
10 anoikis GO:0043276 8.96 MTOR PIK3CA
11 phosphatidylinositol-mediated signaling GO:0048015 8.8 FGFR3 MTOR PIK3CA

Molecular functions related to Dermatosis Papulosa Nigra according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.43 FGFR3 MTOR PIK3CA
2 kinase activity GO:0016301 9.33 FGFR3 MTOR PIK3CA
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.96 FGFR3 PIK3CA
4 1-phosphatidylinositol-3-kinase activity GO:0016303 8.62 FGFR3 PIK3CA

Sources for Dermatosis Papulosa Nigra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....