Desmoid Disease malady

Wikipedia: Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors, which are benign,...⁴⁴ more...

MalaCards: Desmoid Disease, also known as fibromatosis, aggressive, is related to desmoid tumor and fibromatosis. An important gene associated with Desmoid Disease is APC (adenomatous polyposis coli), and among its related pathways are Endometrial cancer and Basal cell carcinoma. The compounds 1-hydroxyanthraquinone and methylazoxymethanol acetate have been mentioned in the context of this disorder. Related mouse phenotype pigmentation.

desmoid disease 7 fibromatosis, aggressive 43

Diseases related to desmoid disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 58)

id	Related Disease	Score	Top Affiliating Genes
1	desmoid tumor	28.6	APC, CTNNB1
2	fibromatosis	28.5	CTNNB1, APC
3	gardner syndrome	12.6	APC, CTNNB1
4	gastrointestinal stromal tumor	12.6	CTNNB1, APC
5	cerebellar liponeurocytoma	12.6	APC, CTNNB1
6	attenuated familial adenomatous polyposis	12.6	CTNNB1, APC
7	juvenile polyposis syndrome	12.6	CTNNB1, APC
8	pancreatoblastoma	12.6	CTNNB1, APC
9	hepatic adenoma	12.6	APC, CTNNB1
10	small intestine adenocarcinoma	12.6	APC, CTNNB1
11	breast metaplastic carcinoma	12.6	APC, CTNNB1
12	turcot syndrome	12.6	CTNNB1, APC
13	lynch syndrome	12.6	APC, CTNNB1
14	acinar cell carcinoma	12.6	CTNNB1, APC
15	colonic polyps	12.6	APC, CTNNB1
16	alveolar soft part sarcoma	12.6	CTNNB1, APC
17	childhood medulloblastoma	12.6	CTNNB1, APC
18	adrenal adenoma	12.6	APC, CTNNB1
19	angiofibroma	12.6	CTNNB1, APC
20	hepatocellular cancer	12.6	APC, CTNNB1
21	parathyroid adenoma	12.6	APC, CTNNB1
22	thyroid cancer, follicular	12.6	APC, CTNNB1
23	peutz-jeghers syndrome	12.5	CTNNB1, APC
24	colorectal adenoma and carcinoma	12.5	APC, CTNNB1
25	ovarian mucinous neoplasm	12.5	APC, CTNNB1
26	bannayan-riley-ruvalcaba syndrome	12.5	APC, CTNNB1
27	adrenocortical tumor	12.5	APC, CTNNB1
28	ependymoma	12.5	CTNNB1, APC
29	neuroendocrine carcinoma	12.5	APC, CTNNB1
30	gallbladder carcinoma	12.5	APC, CTNNB1
31	carcinoid tumors	12.5	CTNNB1, APC
32	adenomatous polyposis coli	12.5	CTNNB1, APC
33	multiple endocrine neoplasia	12.5	APC, CTNNB1
34	breast cancer	12.5	APC, CTNNB1
35	synovial sarcoma	12.5	CTNNB1, APC
36	familial adenomatous polyposis	12.5	APC, CTNNB1
37	barrett's esophagus	12.5	CTNNB1, APC
38	nonencapsulated sclerosing carcinoma	12.5	APC, CTNNB1
39	stomach carcinoma	12.5	CTNNB1, APC
40	pituitary tumor	12.4	APC, CTNNB1
41	neuroendocrine tumor	12.4	APC, CTNNB1
42	malignant mesothelioma	12.4	CTNNB1, APC
43	prostate cancer, progression of	12.4	APC, CTNNB1
44	pancreatic ductal adenocarcinoma	12.4	CTNNB1, APC
45	hepatoblastoma	12.4	APC, CTNNB1
46	esophageal carcinoma	12.4	APC, CTNNB1
47	boomerang dysplasia	12.4	APC, CTNNB1
48	noma	12.3	CTNNB1, APC
49	gastric adenocarcinoma	12.3	CTNNB1, APC
50	pancreatic ductal carcinoma	12.3	APC, CTNNB1

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to desmoid disease:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation phenotype	MP:0001186	9.1	APC, CTNNB1

Articles related to desmoid disease:

id	Title	Authors	Year	Affiliating Genes
1	Gene expression profiling in familial adenomatous pol yposis adenomas and desmoid disease. (19725988)	Bowden N.A.... Scott R.J.	2007	CTNNB1
2	Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene. (8940264)	Eccles D.M.... Fodde R.	1996	APC

Genes related to desmoid disease according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	APC	adenomatous polyposis coli	11.0	Publications
2	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications

Pathways related to desmoid disease according to GeneDecks:

(show all 16)

id	Pathway	Score	Top Affiliating Genes
1	Endometrial cancer20	9.4	APC, CTNNB1
2	Basal cell carcinoma20	9.4	APC, CTNNB1
3	Glioblastoma Multiforme36	9.4	APC, CTNNB1
4	Reelin Pathway (Cajal-Retzius cells)36	9.4	APC, CTNNB1
5	Wnt Signaling Pathway37	9.4	CTNNB1, APC
6	G12-G13 in Cellular Signaling36	9.4	APC, CTNNB1
7	Wnt / Hedgehog / Notch3	9.4	APC, CTNNB1
8	Factors Promoting Cardiogenesis in Vertebrates36	9.3	APC, CTNNB1
9	Human Embryonic Stem Cell Pluripotency36	9.3	CTNNB1, APC
10	Presenilin-Mediated Signaling36	9.3	APC, CTNNB1
11	Wnt signaling pathway20	9.2	APC, CTNNB1
12	Colorectal Cancer Metastasis36	9.2	APC, CTNNB1
13	Nanog in Mammalian ESC Pluripotency36	9.1	CTNNB1, APC
14	Pathways in cancer20	9.1	APC, CTNNB1
15	WNT Signaling36	9.0	APC, CTNNB1
16	GSK3 Signaling36	8.8	APC, CTNNB1

Compounds related to desmoid disease according to GeneDecks:

(show all 26)

id	Compound	Score	Top Affiliating Genes
1	1-hydroxyanthraquinone32	9.5	APC, CTNNB1
2	methylazoxymethanol acetate32	9.5	APC, CTNNB1
3	samp32	9.5	APC, CTNNB1
4	1,2-dimethylhydrazine32	9.5	CTNNB1, APC
5	azoxymethane32	9.5	APC, CTNNB1
6	2-amino-3-methylimidazo(4,5-f)quinoline32	9.5	APC, CTNNB1
7	exisulind32	9.5	CTNNB1, APC
8	sodium bisulfite32	9.5	APC, CTNNB1
9	phip32	9.5	APC, CTNNB1
10	crcs32	9.4	APC, CTNNB1
11	sulindac32 9 9	11.4	CTNNB1, APC
12	lithium32 34 9 18 9	13.4	APC, CTNNB1
13	celecoxib32 42 34 9 18 9	14.4	APC, CTNNB1
14	linoleic acid32 18	10.4	CTNNB1, APC
15	nocodazole32 42 9 9	12.4	APC, CTNNB1
16	curcumin32	9.4	APC, CTNNB1
17	5-aza-2deoxycytidine32	9.4	CTNNB1, APC
18	aspirin32 34 18	11.3	APC, CTNNB1
19	pyruvate32	9.3	APC, CTNNB1
20	guanine32 9 18 9	12.3	CTNNB1, APC
21	nmda32 42	10.2	APC, CTNNB1
22	vitamin d32	9.2	APC, CTNNB1
23	phospholipid32	9.1	CTNNB1, APC
24	glycogen32 18	10.1	APC, CTNNB1
25	rapamycin32 42	10.0	APC, CTNNB1
26	wortmannin32 42	9.8	APC, CTNNB1

Cellular components related to desmoid disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	APC-Axin-1-beta-catenin complex	GO:034742	9.2	APC, CTNNB1
2	Axin-APC-beta-catenin-GSK3B complex	GO:034747	9.1	APC, CTNNB1
3	centrosome	GO:005813	9.1	APC, CTNNB1
4	cell-cell adherens junction	GO:005913	9.0	CTNNB1, APC
5	lateral plasma membrane	GO:016328	8.8	APC, CTNNB1

Biological processes related to desmoid disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	skin development	GO:043588	9.2	APC, CTNNB1
2	cellular component disassembly involved in apoptotic process	GO:006921	9.2	APC, CTNNB1
3	canonical Wnt receptor signaling pathway	GO:060070	9.1	APC, CTNNB1
4	negative regulation of cell proliferation	GO:008285	9.1	APC, CTNNB1
5	positive regulation of apoptotic process	GO:043065	9.0	CTNNB1, APC
6	response to drug	GO:042493	8.8	APC, CTNNB1

Molecular functions related to desmoid disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cadherin binding	GO:045296	9.1	APC, CTNNB1