MCID: DSM004
MIFTS: 58

Desmoid Tumor malady

Cancer diseases, Muscle diseases, Genetic diseases categories

Summaries for Desmoid Tumor

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42NIH Rare Diseases, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 A desmoid tumor is the abnormal growth of cells in connective tissues, which are tissues that help to maintain the structure of the body and include the tissues covering muscle (fascia), cartilage and fat.  though these tumors have a tendency to invade surrounding tissues and organs (be aggressive), they rarely spread to more distant parts of the body (metastasize).  desmoid tumors occur in 2-5 people per million and are most often found in the muscles of the shoulder or abdominal wall, though they can occur in other parts of the body as well.  the first signs that a desmoid tumor is growing include a growing mass or lump; if the mass presses on other parts of the body, it could cause moderate pain, numbness, tingling, or limit the movement of limbs.  a desmoid tumor is usually diagnosed by magnetic resonance imaging (mri) followed by a biopsy.  treatment consists of surgery to remove as much of the tumor as possible; radiation therapy, chemotherapy, or hormone therapy may also be used to reduce the chance that the tumor might regrow following surgery.  the cause of desmoid tumors is not completely clear;  however, approximately 5% of these tumors are associated with an inherited colon cancer syndrome known as familial adenomatous polyposis (fap). last updated: 10/27/2011

MalaCards: Desmoid Tumor, also known as aggressive fibromatosis, is related to familial adenomatous polyposis and gastrointestinal stromal tumor, and has symptoms including polyposis of the bowel/colon/intestine, fibromatosis/bone fibroma and muscle anomalies. An important gene associated with Desmoid Tumor is APC (adenomatous polyposis coli), and among its related pathways are TGF-Beta Pathway and Cardiac Progenitor Differentiation. The compounds cycloheximide and dmpq dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include bone, colon and skin, and related mouse phenotypes are renal/urinary system and vision/eye.

Genetics Home Reference:21 A desmoid tumor is an abnormal growth that arises from connective tissue, which is the tissue that provides strength and flexibility to structures such as bones, ligaments, and muscles. Typically, a single tumor develops, although some people have multiple tumors. The tumors can occur anywhere in the body. Tumors that form in the abdominal wall are called abdominal desmoid tumors; those that arise from the tissue that connects the abdominal organs are called intra-abdominal desmoid tumors; and tumors found in other regions of the body are called extra-abdominal desmoid tumors. Extra-abdominal tumors occur most often in the shoulders, upper arms, and upper legs.

Wikipedia:63 Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors, which are benign,... more...

Description from OMIM:46 135290

Aliases & Classifications for Desmoid Tumor

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42NIH Rare Diseases, 21Genetics Home Reference, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases
Anatomical: Muscle diseases


Characteristics (Orphanet epidemiological data):

48
desmoid tumor:
Inheritance: Sporadic; Age of onset: Adolescence / Young adulthood; Age of death: Normal


Aliases & Descriptions:

desmoid tumor 42 21 44 48
aggressive fibromatosis 42 21 48
desmoid disease, hereditary 46 60
familial infiltrative fibromatosis 21
musculoaponeurotic fibromatosis 21
hereditary desmoid disease 21
desmoid type fibromatosis 48
fibromatosis, aggressive 60
desmoid fibromatosis 21
deep fibromatosis 21


External Ids:

OMIM46 135290
ICD10 via Orphanet26 D48.1

Related Diseases for Desmoid Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Desmoid Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1familial adenomatous polyposis31.1PTGS1, MMP7, CDH2, CTNNB1, APC, COX5A
2gastrointestinal stromal tumor30.5KIT, PDGFRA
3fibrosarcoma30.4ACTC1, CDH2, DES, PDGFRA, PDGFRB
4colon cancer30.4PTGS1, MMP7, CDKN1B, CDH2, CTSD, CTNNB1
5cholangiocarcinoma30.3MMP7, CDKN1B
6lung cancer30.3MMP7, PDGFRA, PDGFRB, PDGFB
7fibrous histiocytoma30.2ACTC1, DES
8sarcoma30.2ACTC1, KIT, MMP7, MKI67, DES, WT1
9hepatitis30.0PDGFB
10neurofibromatosis30.0PDGFRA
11pheochromocytoma30.0CDH2, IGFBP6
12seminoma30.0KIT, PDGFRA
13cutaneous fibrous histiocytoma30.0ACTC1, DES, PDGFB, S100A1
14papillary thyroid carcinoma30.0MMP7, CTNNB1, APC, S100A1
15breast cancer30.0CDKN1B, CTSD, CTNNB1, APC
16chondrosarcoma30.0MMP7, DES, PDGFRA, PDGFRB, S100A1
17papillary carcinoma30.0ACTC1, CDKN1B, MKI67, S100A1
18meningioma30.0MKI67, CTSD, PDGFRB, PDGFB, S100A1
19endometriosis30.0ACTC1, MMP7, CDH2, PDGFRA, COX5A
20leiomyosarcoma30.0ACTC1, KIT, DES, WT1, PDGFRA, PDGFRB
21astrocytoma30.0CDKN1B, CDH2, MKI67, PDGFRA, PDGFRB, PDGFB
22leiomyoma30.0ACTC1, KIT, CDH2, MKI67, DES, PDGFRA
23paraganglioma30.0KIT, S100A1
24prostate cancer30.0PTGS1, MMP7, CDKN1B, CDH2, MKI67, CTSD
25desmoid disease, hereditary10.4
26pancreatitis10.4
27mediastinitis10.3
28breast reconstruction10.2
29ureteral obstruction10.2
30cervicitis10.2
31histiocytoma10.2
32parametritis10.1
33ossifying fibroma10.1
34panhypopituitarism10.1
35diabetes insipidus10.1
36intussusception10.1
37gingivitis10.1
38eosinophilia-myalgia syndrome10.0
39short bowel syndrome10.0
40melorheostosis10.0
41trichinosis10.0
42duodenitis10.0
43hepatitis a10.0
44calcinosis10.0
45duodenal obstruction10.0
46eosinophilia10.0
47foramen magnum meningioma10.0
48lipomatosis10.0
49lymph node cancer10.0
50muscular dystrophy10.0

Graphical network of the top 20 diseases related to Desmoid Tumor:



Diseases related to desmoid tumor

Clinical Features for Desmoid Tumor

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46OMIM, 48Orphanet
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Clinical features from OMIM:

135290

Clinical synopsis from OMIM:

135290

Symptoms:

48 (show all 21)
  • polyposis of the bowel/colon/intestine
  • fibromatosis/bone fibroma
  • muscle anomalies
  • skin tumors/lumps/epidermal cysts
  • sepsis severe/septicemia
  • bladder and ureter anomalies
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • anomalies of the abdominal wall
  • megaureter/hydronephrosis/pyeloureteral junction syndrome
  • intestinal obstruction/ileus
  • malabsorption/chronic diarrhea/steatorrhea
  • restricted joint mobility/joint stiffness/ankylosis
  • retinitis pigmentosa/retinal pigmentary changes
  • articular/joint pain/arthralgia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • thoracic/chest pain
  • myalgia/muscular pain
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • osteolysis/osteoclasia/bone destruction/erosions
  • early death/lethality

Drugs & Therapeutics for Desmoid Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Desmoid Tumor

Search NIH Clinical Center for Desmoid Tumor

Search CenterWatch for Desmoid Tumor

Genetic Tests for Desmoid Tumor

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Anatomical Context for Desmoid Tumor

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32MalaCards
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MalaCards organs/tissues related to Desmoid Tumor:

32
Bone, Colon, Skin

Animal Models for Desmoid Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Desmoid Tumor:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.4PDGFB, APC, PTGS1
2MP:000539110.2PDGFB, APC, CTSD, MMP7
3MP:000538010.1PDGFB, APC, CTNNBIP1, CDH2
4MP:000538810.0PDGFRA, CTNNBIP1, CTNNB1, CDKN1B, PTGS1
5MP:00107719.9PDGFB, PDGFRA, APC, CTNNB1, CDKN1B
6MP:00053699.8ACTC1, PDGFB, PDGFRB, PDGFRA, APC, WT1
7MP:00053899.8PDGFRA, APC, WT1, CTNNB1, CDKN1B, PTGS1
8MP:00053909.7PDGFRA, APC, CTNNBIP1
9MP:00053799.7PDGFRB, PDGFRA, WT1, CTSD, CDKN1B, KIT
10MP:00020069.7PDGFRA, APC, CTNNB1, CDKN1B, MMP7, KIT
11MP:00053829.7PDGFRB, PDGFRA, APC, CTNNBIP1, CTNNB1, CDKN1B
12MP:00053709.6KIT, CDKN1B, CTNNB1, WT1, APC, PDGFB
13MP:00053769.6PDGFB, PDGFRB, PDGFRA, CTSD, DES, CDH2
14MP:00036319.6PDGFB, APC, CTNNBIP1, CTSD, CDH2, KIT
15MP:00030129.6PDGFB, PDGFRA, APC, WT1, CTNNB1, CDKN1B
16MP:00028739.4S100A1, PDGFRB, PDGFRA, APC, WT1, CTNNB1
17MP:00053819.4PDGFRB, PDGFRA, APC, CTNNBIP1, CTNNB1, CTSD
18MP:00053979.3PDGFB, PDGFRB, PDGFRA, APC, WT1, CTNNB1
19MP:00053879.2PDGFB, PDGFRB, PDGFRA, APC, WT1, CTNNB1
20MP:00053869.1S100A1, PDGFRA, APC, CTNNB1, CTSD, DES
21MP:00053788.9WT1, APC, PDGFRA, PDGFRB, PDGFB, CTNNB1
22MP:00053848.9CTNNBIP1, WT1, APC, PDGFRA, PDGFRB, CTNNB1
23MP:00053858.8WT1, APC, PDGFRA, PDGFRB, PDGFB, S100A1
24MP:00107688.6PDGFB, PDGFRB, PDGFRA, APC, WT1, CTNNBIP1

Publications for Desmoid Tumor

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Genetic Variations for Desmoid Tumor

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Expression for genes affiliated with Desmoid Tumor

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Desmoid Tumor

Search GEO for disease gene expression data for Desmoid Tumor.

Pathways for genes affiliated with Desmoid Tumor

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore, 4Cell Signaling Technology, 52R&D Systems, 29KEGG, 53Reactome
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Pathways related to Desmoid Tumor according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2MCM5, PDGFB
210.1PDGFRA, KIT, ACTC1
3
Hide members
10.1KIT, PDGFRA, PDGFRB
4
Cytoskeleton remodeling Role of PDGFs in cell migration
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10.1PDGFRA, PDGFRB, PDGFB
510.1PDGFB, PDGFRB, PDGFRA
610.1MMP7, PDGFRA, PDGFRB
7
Hide members
10.1MMP7, PDGFRA, PDGFB
810.1PDGFRB, PDGFRA, CDKN1B
910.1APC, CTNNBIP1, CTNNB1
1010.0PTGS1, CDKN1B, CTNNB1
1110.0ACTC1, CDH2, CTNNB1
12
Hide members
10.0PDGFB, PDGFRB, PDGFRA, APC
13
Hide members
10.0CTNNB1, PDGFRA, PDGFRB, PDGFB
14
Hide members
9.9APC, CTNNB1, CDKN1B, MMP7
15
Hide members
9.9APC, CTNNBIP1, CTNNB1, MMP7
169.9MMP7, CDH2, CTNNB1, APC
17
Hide members
9.9CTNNB1, DES, CDH2, ACTC1
18
Hide members
9.9PDGFB, PDGFRB, CDKN1B, PTGS1
199.9PDGFB, PDGFRB, PDGFRA, CDH2
20
Hide members
9.9CTNNB1, APC, PDGFRA, PDGFRB, PDGFB
219.9PDGFB, PDGFRB, PDGFRA, APC, CTNNB1
22
Hide members
9.9PDGFB, PDGFRB, PDGFRA, APC, CTNNB1
23
Hide members
9.8PDGFB, PDGFRB, PDGFRA, CTNNB1, KIT
249.8PDGFB, PDGFRB, PDGFRA, APC, CDKN1B
25
Hide members
9.8CDKN1B, CTNNB1, PDGFRA, PDGFRB, PDGFB
26
Hide members
9.8PDGFB, PDGFRB, PDGFRA, CTNNB1, CDKN1B
27
Hide members
9.8KIT, CDKN1B, PDGFRA, PDGFRB, PDGFB
28
Hide members
9.8KIT, CDKN1B, PDGFRA, PDGFRB, PDGFB
29
Hide members
9.8PDGFB, PDGFRB, PDGFRA, CDKN1B, KIT
309.8PDGFB, PDGFRB, PDGFRA, CDKN1B, KIT
31
Hide members
9.8PDGFB, PDGFRB, PDGFRA, CDKN1B, KIT
329.8CDKN1B, CTNNB1, WT1, APC, PDGFRA
339.7CDKN1B, CTNNB1, APC, PDGFRA, PDGFRB, PDGFB
34
Hide members
9.7PDGFB, PDGFRB, PDGFRA, CTNNB1, CTSD, CDKN1B
35
Hide members
9.6PDGFB, PDGFRB, PDGFRA, CTNNB1, CDH2, KIT
369.6PDGFB, PDGFRB, PDGFRA, APC, CTNNB1, CDKN1B
37
Hide members
9.5PDGFB, PDGFRB, PDGFRA, APC, CTNNB1, CDH2
38
Hide members
9.2PDGFB, PDGFRB, PDGFRA, APC, CTNNB1, DES

Compounds for genes affiliated with Desmoid Tumor

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Desmoid Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7PDGFB
2dmpq dihydrochloride5910.4PDGFRB, PDGFRA, PDGFB
3sunitinib malate5910.4PDGFRA, PDGFB, PDGFRB
4su 16f5910.4PDGFB, PDGFRB, PDGFRA
5su 66685910.3PDGFB, PDGFRA, PDGFRB
6azoxymethane4410.3CTNNB1, CDKN1B, APC, COX5A
7dexamethasone44 49 28 1113.1CDKN1B, PDGFB, CTNNB1, CDH2
8b 7234410.0ACTC1, CDH2, DES, WT1, S100A1
9hematoxylin4410.0ACTC1, KIT, MKI67, DES, S100A1
10sulindac44 1111.0COX5A, APC, PTGS1, CTNNB1
11paclitaxel44 49 1112.0CDKN1B, PDGFRB, CTNNB1, CTSD
12pkc 4124410.0PDGFRB, PDGFRA, KIT
13silver4410.0MKI67, DES, CTSD, PDGFB, S100A1
14tgf beta14410.0CTNNB1, CDKN1B, PDGFRA, MKI67, PDGFRB, PDGFB
15p0024410.0KIT, MMP7, MKI67, DES, CTSD, CTNNB1
16bromodeoxyuridine4410.0CDKN1B, DES, CTNNB1, PDGFRB, PDGFB, MKI67
17agar449.9PDGFRB, CTNNB1, CTSD, CDKN1B, PTGS1, PDGFB
18biotin44 11 2411.9S100A1, CTNNB1, DES, MKI67, ACTC1
19formaldehyde44 2410.9CTSD, DES, MKI67, ACTC1, KIT, CDKN1B
20celecoxib44 59 28 49 11 2414.9PTGS1, COX5A, APC, CTNNB1, CDKN1B, MKI67
21trastuzumab44 49 1111.9CDKN1B, KIT, CTNNB1, CTSD
225fluorouracil449.9CDKN1B, MKI67, CTSD, CTNNB1, KIT, PDGFRB
23glucose449.9CDH2, APC, MMP7, PDGFRB, ACTC1, CTSD
24ribonucleic acid449.9PDGFRB, WT1, IGFBP6, MMP7, ACTC1, PDGFB
25phosphotyrosine449.9PDGFB, KIT, CDH2, CTNNB1, PDGFRB, PDGFRA
26methionine449.8CTSD, APC, PDGFRB, DES, KIT, CDKN1B
27oxygen44 2410.8PTGS1, MKI67, DES, CTSD, COX5A, CDKN1B
28rapamycin449.8APC, CTNNB1, PDGFRB, CDKN1B, KIT, PDGFRA
29curcumin449.7COX5A, APC, WT1, PTGS1, CTNNB1
30genistein44 28 59 2 11 2414.7PDGFRB, COX5A, CTSD, CTNNB1, CDKN1B, PTGS1
31h2o2449.6PTGS1, COX5A, CTNNB1, CTSD, DES, CDKN1B
32lysine449.6CTSD, CDKN1B, CDH2, MKI67, DES, CTNNB1
33phosphatidylinositol449.6PDGFRA, PDGFRB, KIT, CDKN1B, MMP7, CDH2
34imatinib44 49 1111.5PDGFB, PDGFRB, PDGFRA, WT1, CTNNB1, DES
35glycogen44 2410.5DES, KIT, S100A1, ACTC1, APC, CDKN1B
36threonine449.5KIT, WT1, CDKN1B, PDGFRB, APC, CTNNB1
37doxorubicin44 49 1111.5KIT, CTNNB1, COX5A, MMP7, DES, MKI67
38oligonucleotide449.5KIT, APC, PDGFRB, PDGFRA, WT1, CTNNB1
39serine449.4COX5A, PDGFB, APC, WT1, DES, MKI67
40thymidine44 2410.4WT1, PDGFB, IGFBP6, DES, CTSD, CTNNB1
41testosterone44 59 11 2412.2CTSD, KIT, PDGFRB, CDKN1B, CDH2, MKI67
42cysteine449.1CTSD, DES, CDH2, KIT, CTNNB1, WT1
43nitric oxide44 11 2411.1S100A1, COX5A, PTGS1, KIT, CDKN1B, MMP7
44calcium44 49 11 2412.0S100A1, MKI67, IGFBP6, DES, ACTC1, CTSD
45atp44 289.9PDGFRA, KIT, COX5A, PDGFRB, CTNNB1, CTSD
46tyrosine448.6DES, MKI67, ACTC1, PDGFRB, PDGFRA, APC
47vegf448.6PDGFB, COX5A, MMP7, WT1, CTSD, DES
48paraffin448.5CTNNB1, CTSD, DES, MKI67, CDH2, CDKN1B
49retinoic acid44 249.4MKI67, CDKN1B, KIT, MMP7, IGFBP6, CDH2
50progesterone44 59 28 11 2412.4CTNNB1, WT1, PDGFRB, PDGFB, S100A1, COX5A

GO Terms for genes affiliated with Desmoid Tumor

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16Gene Ontology
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Cellular components related to Desmoid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.2APC, CTNNBIP1, CTNNB1
2intrinsic to plasma membraneGO:03122610.1PDGFRA, PDGFRB
3fascia adherensGO:00591610.1CDH2, DES, CTNNB1
4cell-cell adherens junctionGO:00591310.1APC, CTNNB1, CDH2
5catenin complexGO:0163429.9CTNNB1, CDH2
6cytoplasmGO:0057378.7CTNNB1, PDGFRB, WT1, CTNNBIP1, APC, MKI67
7nucleusGO:0056348.6KIT, MCM5, CDKN1B, MKI67, CTNNB1, CTNNBIP1

Biological processes related to Desmoid Tumor according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular mesangial cell proliferation involved in metanephros developmentGO:07226210.6PDGFRB, PDGFB
2metanephric glomerular capillary formationGO:07227710.6PDGFRB, PDGFRA
3positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.6PDGFRB, PDGFRA
4positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayGO:03579310.6PDGFB, PDGFRB
5positive regulation of phospholipase C activityGO:01086310.5PDGFRB, PDGFRA, KIT
6cardiac myofibril assemblyGO:05500310.5PDGFRB, PDGFRA, ACTC1
7positive regulation of fibroblast growth factor receptor signaling pathwayGO:04574310.5CTNNB1, PDGFB
8metanephric S-shaped body morphogenesisGO:07228410.5WT1, PDGFRB
9retina vasculature development in camera-type eyeGO:06129810.5PDGFRA, PDGFRB
10platelet-derived growth factor receptor signaling pathwayGO:04800810.5PDGFRA, PDGFRB, PDGFB
11negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:06077010.5CDKN1B, APC
12male genitalia developmentGO:03053910.4CTNNB1, WT1, PDGFRA
13positive regulation of DNA biosynthetic processGO:200057310.4PDGFB, PDGFRB
14adrenal gland developmentGO:03032510.4PDGFRB, PDGFRA, WT1
15negative regulation of platelet activationGO:01054410.4PDGFRA, PDGFB
16cell chemotaxisGO:06032610.4KIT, PDGFRA, PDGFRB, PDGFB
17metanephric mesenchyme developmentGO:07207510.4PDGFRB, WT1
18positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.4KIT, PDGFRA, PDGFRB, PDGFB
19response to estradiol stimulusGO:03235510.4PDGFB, PDGFRB, CTNNB1
20positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.4PDGFB, PDGFRB, PDGFRA, KIT
21positive regulation of chemotaxisGO:05092110.4PDGFRB, PDGFB
22peptidyl-tyrosine phosphorylationGO:01810810.4KIT, PDGFRA, PDGFRB, PDGFB
23positive regulation of cell migrationGO:03033510.3PDGFB, PDGFRB, PDGFRA, APC
24positive regulation of calcium ion importGO:09028010.3PDGFRB, PDGFB
25branching involved in ureteric bud morphogenesisGO:00165810.3CTNNB1, CTNNBIP1, WT1
26positive regulation of MAPK cascadeGO:04341010.3PDGFB, CTNNB1, CDH2, KIT
27positive regulation of microtubule polymerizationGO:03111610.3APC, CDKN1B
28positive regulation of smooth muscle cell migrationGO:01491110.2PDGFRB, PDGFB
29phosphatidylinositol-mediated signalingGO:04801510.2KIT, CDKN1B, PDGFRA, PDGFRB, PDGFB
30fibroblast growth factor receptor signaling pathwayGO:00854310.2KIT, CDKN1B, PDGFRA, PDGFRB, PDGFB
31Fc-epsilon receptor signaling pathwayGO:03809510.2KIT, CDKN1B, PDGFRA, PDGFRB, PDGFB
32epidermal growth factor receptor signaling pathwayGO:00717310.2PDGFB, PDGFRB, PDGFRA, CDKN1B, KIT
33neurotrophin TRK receptor signaling pathwayGO:04801110.2PDGFB, PDGFRB, PDGFRA, CDKN1B, KIT
34positive regulation of ERK1 and ERK2 cascadeGO:07037410.1PDGFRA, PDGFRB, PDGFB
35positive regulation of cell proliferationGO:00828410.1PDGFB, PDGFRB, PDGFRA, CDKN1B, KIT
36negative regulation of cell proliferationGO:00828510.0APC, WT1, CTNNB1, IGFBP6, CDKN1B
37innate immune responseGO:04508710.0PDGFB, PDGFRB, PDGFRA, CTNNB1, CDKN1B, KIT
38extracellular matrix organizationGO:0301989.8MMP7, CTSD, PDGFRA, PDGFB
39response to drugGO:0424939.7PDGFB, CTNNB1, MMP7, ACTC1

Molecular functions related to Desmoid Tumor according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:03808510.3PDGFRB, PDGFRA
2platelet-derived growth factor bindingGO:04840710.3PDGFB, PDGFRB, PDGFRA
3platelet-derived growth factor receptor bindingGO:00516110.2PDGFRB, PDGFB, PDGFRA
4gamma-catenin bindingGO:04529510.2CDH2, APC
5protein phosphatase bindingGO:01990310.0CDKN1B, CDH2, CTNNB1
6beta-catenin bindingGO:0080139.9APC, CTNNBIP1, CDH2
7alpha-catenin bindingGO:0452949.9CDH2, CTNNB1
8protein bindingGO:0055158.3WT1, APC, PDGFRA, PDGFRB, PDGFB, S100A1

Products for genes affiliated with Desmoid Tumor

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  • Antibodies
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Sources for Desmoid Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet