Desmoid Tumor malady

NIH Rare Diseases: A desmoid tumor is the abnormal growth of cells in connective tissues, which are tissues that help to maintain the structure of the body and include the tissues covering muscle (fascia), cartilage and fat.  Though these tumors have a tendency to invade surrounding tissues and organs (be aggressive), they rarely spread to more distant parts of the body (metastasize).  Desmoid tumors occur in 2-5 people per million and are most often found in the muscles of the shoulder or abdominal wall, though they can occur in other parts of the body as well.  The first signs that a desmoid tumor is growing include a growing mass or lump; if the mass presses on other parts of the body, it could cause moderate pain, numbness, tingling, or limit the movement of limbs.  A desmoid tumor is usually diagnosed by magnetic resonance imaging (MRI) followed by a biopsy.  Treatment consists of surgery to remove as much of the tumor as possible; radiation therapy, chemotherapy, or hormone therapy may also be used to reduce the chance that the tumor might regrow following surgery.  The cause of desmoid tumors is not completely clear;  however, approximately 5% of these tumors are associated with an inherited colon cancer syndrome known as familial adenomatous polyposis (FAP).³⁰

MalaCards: Desmoid Tumor, also known as fibromatosis, aggressive, is related to desmoid disease and attenuated familial adenomatous polyposis. An important gene associated with Desmoid Tumor is CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa), and among its related pathways are Breast Cancer Regulation by Stathmin1 and Human Embryonic Stem Cell Pluripotency. The compounds egcg and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and b cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors, which are benign,...⁴⁴ more...

desmoid tumor 30 32 fibromatosis, aggressive 43

aggressive fibromatosis 30

Diseases related to desmoid tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 592)

id	Related Disease	Score	Top Affiliating Genes
1	desmoid disease	31.4	APC, CTNNB1
2	attenuated familial adenomatous polyposis	29.3	APC, PTGS2, CTNNB1
3	familial adenomatous polyposis	29.2	PCNA, RB1, SERPINE1, CDH2, MMP7, APC
4	fibromatosis	27.4	KIT, PCNA, RB1, SERPINE1, S100A1, CDH2
5	adenomatous polyposis coli	26.9	CDH2, AR, APC, CCND1, ESR1, PTGS2
6	malignant fibrous histiocytoma	26.7	PCNA, RB1, S100A1, CDKN2A, MKI67, PTGS2
7	fibrous histiocytoma	26.5	PCNA, RB1, S100A1, CDKN2A, MKI67, PTGS2
8	histiocytoma	26.5	PCNA, RB1, S100A1, CDKN2A, MKI67, PTGS2
9	polyposis	25.1	PCNA, RB1, SERPINE1, CDH2, CDKN1B, CDKN2A
10	wilms tumor	24.0	PCNA, CDKN2A, AR, CCND1, ESR1, TNF
11	carcinoma	17.2	KIT, PCNA, RB1, SERPINE1, S100A1, CDH2
12	gastrointestinal stromal tumor, somatic	13.7	KIT, PDGFRA
13	pseudosarcomatous fibromatosis	13.7	CTNNB1, ACTC1, DES
14	cutaneous leiomyosarcoma	13.7	KIT, ACTC1, DES
15	epithelioid leiomyosarcoma	13.7	ACTC1, DES
16	glomangiomyoma	13.7	ACTC1, DES
17	infantile myofibromatosis	13.7	ACTC1, DES
18	malignant giant cell tumor of soft parts	13.7	ACTC1, DES
19	glomangioma	13.7	S100A1, ACTC1, DES
20	retroperitoneal leiomyosarcoma	13.6	KIT, S100A1, DES
21	ossifying fibromyxoid tumor	13.6	S100A1, ACTC1, DES
22	spindle cell lipoma	13.6	S100A1, ACTC1, DES
23	sm-ahnmd	13.6	KIT, PDGFRA, PDGFRB
24	ossifying fibroma	13.6	S100A1, ACTC1, DES
25	myoma	13.6	DES, PGR
26	gardner syndrome	13.6	APC, CTNNB1
27	perineurioma	13.6	KIT, PDGFRA, DES
28	carney triad	13.6	KIT, PDGFRA, ACTC1, DES
29	glomus tumor	13.6	S100A1, ACTC1, DES
30	myofibroma	13.6	ACTC1, DES
31	chondroma	13.6	KIT, S100A1, PDGFRA
32	gastric leiomyosarcoma	13.6	PDGFRA, DES, PGR
33	breast metaplastic carcinoma	13.6	S100A1, APC, CTNNB1, DES
34	rectum sarcomatoid carcinoma	13.6	ACTC1, DES, PGR
35	chronic myelomonocytic leukemia	13.6	KIT, PDGFRA, PDGFRB
36	cutaneous fibrous histiocytoma	13.5	S100A1, PDGFB, ACTC1, DES
37	embryonal sarcoma	13.5	KIT, MKI67, DES
38	rosai-dorfman disease	13.5	S100A1, CTSD, PDGFRA
39	cavernous hemangioma of face	13.5	MKI67, ACTC1, DES
40	langerhans-cell histiocytosis	13.5	S100A1, PDGFB
41	eosinophilic myeloproliferative disorder	13.5	PDGFRA, PDGFRB
42	botryoid rhabdomyosarcoma	13.5	WT1, ACTC1, DES
43	pulmonary vein stenosis	13.5	MKI67, PDGFRA, ACTC1, DES
44	childhood mediastinal neurogenic tumor	13.5	WT1, DES
45	rhabdoid tumors	13.5	WT1, ACTC1, DES
46	endometrial stromal tumor	13.4	CCND1, CTNNB1, DES
47	chronic cystitis	13.4	KIT, PTGS1
48	endometrial stromal nodule	13.4	DES, PGR
49	synovial sarcoma	13.4	KIT, MKI67, CTNNB1, DES
50	orbit embryonal rhabdomyosarcoma	13.4	WT1, ACTC1, DES

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to desmoid tumor:

²²

MGI Mouse Phenotypes related to desmoid tumor:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.6	PDGFB
2	endocrine/exocrine gland phenotype	MP:0005379	9.9	CDKN1B, GNRH1, CTNNA1, WT1
3	liver/biliary system phenotype	MP:0005370	9.8	ESR2, AR, KIT
4	craniofacial phenotype	MP:0005382	9.8	PDGFRB, KIT, CTNNBIP1, PDGFRA
5	embryogenesis phenotype	MP:0005380	9.4	CDH2, PDGFRA, PGR, CTNNBIP1, KIT, APC
6	hematopoietic system phenotype	MP:0005397	9.2	KIT, PCNA, APC, CCND1, PDGFB, PDGFRA
7	normal phenotype	MP:0002873	9.0	AR, GNRH1, ESR2, PDGFRA, WT1, PGR
8	pigmentation phenotype	MP:0001186	8.9	PDGFRA, PDGFB, CTNNB1, APC, KIT, RB1
9	other phenotype	MP:0005395	8.7	CTNNA1, PTGS1, PTGS2, ESR2, CDKN2A, PDGFRA
10	integument phenotype	MP:0010771	8.5	RB1, CDKN1B, APC, CCND1, GNRH1, PTGS1
11	behavior/neurological phenotype	MP:0005386	8.3	KIT, PTGS1, PGR, RB1, S100A1, CTSD
12	limbs/digits/tail phenotype	MP:0005371	8.2	KIT, ESR1, PDGFRA, CTNNB1, CTNNA1, ESR2
13	nervous system phenotype	MP:0003631	8.2	CTNNA1, CTSD, PDGFRA, CTNNBIP1, CDH2, RB1
14	immune system phenotype	MP:0005387	8.1	PDGFRA, CDKN1B, MMP7, CCND1, GNRH1, TNF
15	mortality/aging	MP:0010768	8.0	RB1, APC, PDGFRB, DES, PDGFRA, CTNNBIP1
16	no phenotypic analysis	MP:0003012	7.5	PCNA, RB1, CDKN1B, APC, ESR1, ESR2
17	reproductive system phenotype	MP:0005389	7.5	PTGS1, WT1, PTGS2, ESR2, GNRH1, CCND1
18	vision/eye phenotype	MP:0005391	7.1	TNF, CTNNBIP1, CTNNB1, CTSD, PTGS2, PDGFRB
19	digestive/alimentary phenotype	MP:0005381	7.0	PDGFRB, PDGFRA, CTNNBIP1, CTNNB1, MMP7, KIT
20	growth/size phenotype	MP:0005378	6.9	PDGFB, RB1, SERPINE1, CDH2, CDKN1B, MMP7
21	adipose tissue phenotype	MP:0005375	6.9	RB1, ESR2, PTGS2, PDGFRB, ESR1, APC
22	skeleton phenotype	MP:0005390	6.6	ESR1, APC, CCND1, ESR2, PTGS2, CTNNA1
23	renal/urinary system phenotype	MP:0005367	6.5	PDGFRA, KIT, PDGFB, GNRH1, ESR1, CTNNBIP1
24	muscle phenotype	MP:0005369	5.2	RB1, PTGS1, CTNNB1, PDGFB, PDGFRA, PTGS2
25	tumorigenesis	MP:0002006	5.1	APC, KIT, AR, CDKN2A, CDKN1B, SERPINE1
26	cardiovascular system phenotype	MP:0005385	4.8	PGR, DES, ACTC1, WT1, PDGFRB, APC
27	homeostasis/metabolism phenotype	MP:0005376	4.1	CTNNB1, CTSD, PTGS1, KIT, TNF, RB1
28	cellular phenotype	MP:0005384	3.7	PDGFRB, KIT, PCNA, RB1, CDH2, CDKN1B

Articles related to desmoid tumor:

(show all 45)

id	Title	Authors	Year	Affiliating Genes
1	Family history, surgery, and APC mutation are risk fa ctors for desmoid tumors in familial adenomatous polyposis: an international co hort study. (21904137)	Nieuwenhuis M.H.... Vasen H.F.	2011	APC
2	Evaluation of estrogen receptor alpha, estrogen recep tor beta, progesterone receptor, and cKIT expression in desmoids tumors and the ir role in determining treatment options. (20305341)	Santos G.A.... Lopes A.	2010	KIT, PGR, ESR1
3	Molecular characterization by array comparative genom ic hybridization and DNA sequencing of 194 desmoid tumors. (20232483)	Salas S.... Coindre J.M.	2010	APC, CTNNB1
4	Successful treatment with meloxicam, a cyclooxygenase -2 inhibitor, of patients with extra-abdominal desmoid tumors: a pilot study. (20026797)	Nishida Y.... Yamada Y.	2010	PTGS2
5	Identification of somatic APC mutations in recurrent desmoid tumors in a patient with familial adenomatous polyposis to determine actual recurrence of the original tumor or de novo occurrence. (18704758)	Iwama T.... Ishida H.	2009	APC
6	Analysis of pRb, p16INK4A proteins and proliferating antigens: PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor). (19130399)	Stalinska L.... Ferenc T.	2009	RB1, PCNA, CDKN2A
7	The role of APC and beta-catenin in the aetiology of aggressive fibromatosis (desmoid tumors). (18722078)	Lips D.J.... Hennipman A.	2009	CTNNB1
8	Desmoid tumor: from surgical extirpation to molecular dissection. (19436199)	Lazar A.J.... Lev D.	2009	CTNNB1
9	Analysis of APC, alpha-, beta-catenins, and N-cadherin protein expression in aggressive fibromatosis (desmoid tumor). (19124205)	Ferenc T.... Sygut J.	2009	APC, CTNNB1, CDH2
10	Sporadic desmoid tumor in an Ashkenazi patient homozygous for the APC*I1307K gene mutation. (18770064)	Zauber P.... Bishop T.	2008	APC
11	Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors. (18715618)	Matono H.... Tsuneyoshi M.	2008	MMP7, CTNNB1, CTNNBIP1
12	Desmoid tumor: a disease opportune for molecular insights. (17952864)	Kotiligam D.... Lev D.	2008	APC, CTNNB1
13	Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors. (18832571)	Lazar A.J.... Lev D.	2008	CTNNB1
14	The role of imatinib mesylate in adjuvant therapy of extra-abdominal desmoid tumors. (17465254)	Ioannou M.... Kottakis S.	2007	PDGFRA, PDGFRB
15	An association between the 4G polymorphism in the PAI-1 promoter and the development of aggressive fibromatosis (desmoid tumor) in familial adenomatous polyposis patients. (17160433)	Li C.F.... Alman B.A.	2007	SERPINE1, CTNNB1
16	Clinical and molecular studies of the effect of imatinib on advanced aggressive fibromatosis (desmoid tumor). (16505440)	Heinrich M.C.... Fletcher J.A.	2006	PDGFRA, PDGFRB, KIT
17	A comparison of methods for the analysis of low abund ance proteins in desmoid tumor cells. (16729958)	Picariello L.... Tonelli F.	2006	PTGS1, PTGS2
18	Pleuropulmonary desmoid tumors: immunohistochemical comparison with solitary fibrous tumors and assessment of beta-catenin and cyclin D1 expression. (17090192)	Andino L.... Zander D.S.	2006	CCND1, CTNNB1, DES
19	Intrathoracic sporadic desmoid tumor with the beta-catenin gene mutation in exon 3 and activated cyclin D1. (16131791)	Tajima S.... Sugiyama Y.	2006	CCND1, CTNNB1
20	Expression profiles of sex steroid receptors in desmoid tumors. (17077595)	Ishizuka M.... Kokubun S.	2006	AR, PGR
21	Analysis of p27KIP1 protein and Ki-67 expression in aggressive fibromatosis (desmoid tumor). (17285761)	Ferenc T.... Stalinska L.	2006	CDKN1B, MKI67
22	Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor). (15674349)	Fen Li C.... Alman B.A.	2005	SERPINE1
23	Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma. (15793634)	Brueckl W.M.... Wein A.	2005	APC
24	Upregulation of Wilms' tumor gene 1 (WT1) in desmoid tumors. (15540161)	Amini Nik S.... Tejpar S.	2005	CTNNB1, WT1
25	Analysis of Wnt/Beta catenin signalling in desmoid tumors. (15832580)	Tejpar S.... Cassiman J.J.	2005	APC
26	Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors. (14737101)	Denys H.... Tejpar S.	2004	CTNNB1, IGFBP6
27	Comprehensive genetic and endoscopic evaluation may be necessary to distinguish sporadic versus familial adenomatous polyposis-associated abdominal desmoid tumors. (15179376)	Bandipalliam P.... Syngal S.	2004	APC
28	Response of extraabdominal desmoid tumors to therapy with imatinib mesylate. (12436445)	Mace J.... Baker L.	2002	PDGFRA, PDGFRB, KIT
29	Possible association between higher beta-catenin mRNA expression and mutated beta-catenin in sporadic desmoid tumors: real-time semiquantitative assay by TaqMan polymerase chain reaction. (11796830)	Saito T.... Tsuneyoshi M.	2002	CTNNB1
30	Desmoid tumors in three patients (11816139)	Mohos E.... Nagy A.	2001	APC
31	Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). (11313976)	Poon R.... Alman B.A.	2001	APC, CTNNB1, COX5A
32	Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis. (11241320)	Bertario L.... Radice P.	2001	APC
33	Primary fibromatosis of the breast in a patient with multiple desmoid tumors--report of a case with evaluation of estrogen and progesterone receptors. (11770022)	Reis-Filho J.S.... Schmitt F.C.	2001	PGR
34	Treatment of extra-abdominal desmoid tumors with inte rferon-alpha with or without tretinoin. (10649274)	Leithner A.... Zielinski C.C.	2000	IFNA1
35	A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor. (10782927)	Couture J.... Bapat B.	2000	APC, CTNNB1
36	Limb desmoid tumors: a possible role for isolated lim b perfusion with tumor necrosis factor-alpha and melphalan. (10568198)	Lev-Chelouche D.... Gutman M.	1999	TNF
37	An aggressive desmoid tumor in a patient with familial adenomatous polyposis: immunohistochemical findings. (10022664)	Arai N.... Okayasu I.	1999	CTSD
38	Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor). (10597266)	Tejpar S.... Alman B.A.	1999	CTNNB1
39	Desmoid tumors of the pleura: a clinicopathologic mimic of localized fibrous tumor. (9950156)	Wilson R.W.... Moran C.A.	1999	S100A1
40	Frequent mutations in the beta-catenin gene in desmoid tumors from patients without familial adenomatous polyposis. (10367940)	Miyoshi Y.... Nakamura Y.	1998	CTNNB1
41	Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor). (9736021)	Li C.... Alman B.A.	1998	CTNNB1
42	Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). (9250146)	Alman B.A.... Wolfe H.J.	1997	CTNNB1, CDH2
43	Cranial desmoid tumor associated with homozygous inactivation of the adenomatous polyposis coli gene in a 2-year-old girl with familial adenomatous polyposis. (8608492)	de Silva D.C.... Dunlop M.G.	1996	APC
44	Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis. (8221638)	Miyaki M.... Iwama T.	1993	APC
45	Treatment and course of desmoid tumors in 5 patients with familial adenomatous polyposis (8386328)	van Dam J.H.... Kok T.C.	1993	GNRH1

Genes related to desmoid tumor according to GeneCards:

(show all 34)

id	Symbol	Description	Score	GeneCards Section Context
1	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Functions, Publications
2	APC	adenomatous polyposis coli	11.0	Publications
3	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
4	DES	desmin	11.0	Publications
5	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
6	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
7	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
8	PDGFB	platelet-derived growth factor beta polypeptide	11.0
9	IGFBP6	insulin-like growth factor binding protein 6	11.0	Publications
10	MCM5	minichromosome maintenance complex component 5	11.0	Publications
11	CTNNBIP1	catenin, beta interacting protein 1	11.0	Publications
12	S100A1	S100 calcium binding protein A1	11.0	Publications
13	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
14	CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	11.0	Publications
15	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	11.0	Publications
16	CTSD	cathepsin D	11.0	Publications
17	COX5A	cytochrome c oxidase subunit Va	11.0	Publications
18	WT1	Wilms tumor 1	11.0	Publications
19	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
20	PGR	progesterone receptor	11.0	Publications
21	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
22	RB1	retinoblastoma 1	11.0	Publications
23	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
24	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	11.0	Publications
25	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
26	ESR2	estrogen receptor 2 (ER beta)	11.0	Publications
27	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
28	IFNA1	interferon, alpha 1	11.0	Publications
29	CCND1	cyclin D1	11.0	Publications
30	AR	androgen receptor	11.0	Publications
31	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
32	PCNA	proliferating cell nuclear antigen	11.0	Publications
33	ESR1	estrogen receptor 1	11.0	Publications
34	TNF	tumor necrosis factor	11.0	Publications

Pathways related to desmoid tumor according to GeneDecks:

(show top 50)    (show all 71)

id	Pathway	Score	Top Affiliating Genes
1	Breast Cancer Regulation by Stathmin136	10.7	PDGFB
2	Human Embryonic Stem Cell Pluripotency36	10.3	PDGFRA, APC, PDGFRB, PDGFB
3	CDO in myogenesis38	10.2	CDH2, CTNNA1, CTNNB1
4	Cell adhesion Cadherin-mediated cell adhesion10	10.2	CTNNA1, ACTC1, CDH2, CTNNB1
5	Cell adhesion_Cadherin-mediated cell adhesion41	10.2	ACTC1, CDH2, CTNNA1, CTNNB1
6	Endometrial cancer20	10.0	CTNNA1, APC, CCND1, CTNNB1
7	S-1P Stimulated Signaling36	9.9	CDH2, PDGFRB, PDGFB, PDGFRA
8	Arrhythmogenic right ventricular cardiomyopathy (ARVC)20	9.9	CTNNB1, CTNNA1, CDH2, DES
9	Glioblastoma Multiforme36	9.9	PDGFB, CDKN1B, PDGFRA, APC, PDGFRB, RB1
10	Nanog in Mammalian ESC Pluripotency36	9.8	CTNNB1, GNRH1, PDGFB, APC, KIT, PDGFRA
11	p53 Mediated Apoptosis36	9.8	PDGFRB, PDGFRA, PDGFB, GNRH1, KIT
12	Telomerase Components in Cell Signaling36	9.8	PDGFB, GNRH1, KIT, RB1, PDGFRB, PDGFRA
13	PPAR Pathway36	9.8	PDGFRB, PDGFRA, PDGFB, TNF, KIT
14	TOB in T-Cell Signaling36	9.7	CDKN1B, CCND1, RB1
15	Wnt signaling pathway20	9.7	APC, CTNNBIP1, CCND1, CTNNB1, MMP7
16	Mitochondrial Apoptosis36	9.7	CDKN2A, GNRH1, PDGFB, PDGFRA, PDGFRB, KIT
17	GSK3 Signaling36	9.7	KIT, APC, GNRH1, PDGFRA, PDGFB, PDGFRB
18	Angiogenesis3	9.6	PTGS2, MMP7, PDGFRB, PDGFRA
19	Celecoxib Pathway, Pharmacodynamics34	9.6	PTGS1, PTGS2, CDKN1B, CTNNB1
20	14-3-3 Induced Intracellular Signaling36	9.6	PDGFRB, TNF, PDGFB, GNRH1, PDGFRA
21	Apoptotic Pathways in Synovial Fibroblasts36	9.5	PDGFRA, GNRH1, TNF, KIT, PDGFRB, PDGFB
22	G1-S Phase Transition36	9.5	CDKN2A, CDKN1B, CCND1, RB1
23	Glioma20	9.5	PDGFRB, RB1, CDKN2A, CCND1, PDGFRA, PDGFB
24	Melanoma20	9.5	CCND1, PDGFB, PDGFRA, PDGFRB, CDKN2A, RB1
25	JAK-STAT Pathway36	9.5	PDGFRA, PDGFRB, KIT, MCM5, IFNA1, GNRH1
26	Renin-Angiotensin Pathway36	9.4	PTGS2, PDGFRB, PDGFRA, KIT, PDGFB, GNRH1
27	Akt Signaling36	9.4	PDGFRB, PDGFRA, PDGFB, TNF, CCND1, KIT
28	Cyclins and Cell Cycle Regulation36	9.4	RB1, CDKN2A, CCND1, CDKN1B
29	ILK Signaling36	9.3	CTNNB1, PDGFRB, PDGFRA, PTGS2, PDGFB, KIT
30	Cytokine-cytokine receptor interaction20	9.3	PDGFRB, KIT, IFNA1, PDGFB, PDGFRA, TNF
31	Cellular Apoptosis Pathway36	9.2	PDGFB, KIT, CDKN2A, GNRH1, TNF, PDGFRA
32	Rho Family GTPases36	9.2	GNRH1, PDGFB, PDGFRA, PDGFRB, DES, TNF
33	WNT Signaling36	9.2	MMP7, CTNNB1, CTNNA1, CDH2, PTGS2, APC
34	Pathways in cancer20	9.1	RB1, AR, CTNNB1, CDKN1B, CCND1, CTNNA1
35	Cell cycle ESR1 regulation of G1/S transition10	9.1	CDKN1B, RB1, CCND1, ESR1
36	Endothelin-1 Signaling Pathway36	9.1	PDGFRB, TNF, KIT, PTGS2, PTGS1, PDGFRA
37	Chronic myeloid leukemia20	9.1	CDKN2A, CCND1, RB1, CDKN1B
38	Cell cycle_ESR1 regulation of G1/S transition41	9.1	RB1, ESR1, CCND1, CDKN1B
39	MNAR-PELP1 and Estrogen Receptor Interaction36	9.1	RB1, ESR1, ESR2, CCND1
40	Colorectal Cancer Metastasis36	9.0	CCND1, TNF, APC, CTNNB1, PTGS2, MMP7
41	Prostate cancer20	9.0	RB1, PDGFRB, CDKN1B, PDGFRA, AR, CCND1
42	eNOS Signaling36	8.9	ESR2, KIT, ESR1, GNRH1, PDGFRB, PDGFRA
43	Cell Cycle, Mitotic38	8.9	MCM5, CDKN2A, PCNA, CDKN1B, RB1
44	PAK Pathway36	8.8	PDGFRB, PDGFRA, PDGFB, TNF, GNRH1, KIT
45	Cell cycle20	8.8	PCNA, RB1, CDKN2A, CCND1, CDKN1B, MCM5
46	Estrogen-mediated S-Phase Entry36	8.8	ESR2, ESR1, CDKN1B, CCND1, RB1
47	Molecular Mechanisms of Cancer36	8.7	CCND1, GNRH1, RB1, CDKN1B, CDKN2A, APC
48	Estrogen Pathway36	8.5	PDGFB, KIT, CCND1, GNRH1, ESR1, ESR2
49	ERK Signaling36	8.3	ESR1, ESR2, GNRH1, PDGFB, PDGFRB, KIT
50	Pancreatic Adenocarcinoma36	8.1	KIT, CDKN1B, GNRH1, MMP7, PTGS2, PDGFRA

Compounds related to desmoid tumor according to GeneDecks:

(show top 50)    (show all 289)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.5	PTGS1, PDGFRB
2	h2o232	10.2	PDGFRB, ESR2, DES
3	rofecoxib32 9 9	11.9	CCND1, COX5A
4	rapamycin32 42	10.6	AR, PDGFRA, KIT, RB1, PDGFRB
5	progestin32	9.1	AR, CCND1, GNRH1, ESR2, CTSD, DES
6	ns 39832 42	9.9	COX5A, PTGS1, CDKN1B, PCNA, TNF
7	aspartate32	8.8	CTNNB1, GNRH1, CDKN2A, PCNA, PGR
8	ag 147832	8.6	CCND1, SERPINE1, CDKN1B, MMP7, GNRH1, PTGS2
9	ly29400232	8.6	PTGS1, PTGS2, CCND1, TNF, CDKN1B
10	adriamycin32	8.5	CTSD, IFNA1, CCND1, CDKN2A, PGR, COX5A
11	agar32	8.5	PGR, RB1, CDKN2A, CCND1, PTGS1, CTSD
12	sulindac32 9 9	10.5	CTNNB1, PTGS1, APC, PCNA, CCND1, PTGS2
13	imatinib32 34 9 9	11.5	CTNNB1, PDGFB, PDGFRA, PDGFRB, WT1, ACTC1
14	tgf beta132	8.4	CCND1, SERPINE1, CDKN1B, PDGFB, MKI67, TNF
15	glycogen32 18	9.3	ACTC1, CTNNB1, CCND1, APC, MKI67, CDKN1B
16	bromodeoxyuridine32	8.3	CDKN1B, CCND1, DES, RB1, MKI67, CTNNB1
17	ribonucleic acid32	8.3	PGR, ESR2, PDGFRB, ACTC1, WT1, PDGFB
18	dihydrotestosterone32 9 18 9	11.2	GNRH1, ESR1, DES, PGR, AR, SERPINE1
19	steroidal32	8.1	PGR, PTGS1, GNRH1, ESR2, CTSD, ESR1
20	cysteine32	8.1	PTGS1, ESR2, CTSD, CDKN2A, CTNNB1, COX5A
21	formaldehyde32 18	9.1	KIT, ACTC1, RB1, CDKN1B, DES, PCNA
22	celecoxib32 42 34 9 18 9	13.0	PCNA, CDKN1B, CTNNB1, PTGS2, MKI67, APC
23	gefitinib32 34 9 9	11.0	CCND1, ESR1, CDKN1B, PDGFRB, CTNNB1, PTGS2
24	curcumin32	7.7	WT1, COX5A, CTNNB1, AR, PTGS1, APC
25	mifepristone32 42 9 9	10.5	PGR, PTGS2, CTNNB1, ESR1, AR, ESR2
26	oligonucleotide32	7.4	APC, MMP7, CCND1, CTNNA1, CTNNB1, PDGFB
27	5-aza-2deoxycytidine32	7.1	IFNA1, APC, AR, PCNA, CDH2, CTNNB1
28	tyrosine32	7.1	RB1, PDGFB, CTNNB1, CTNNA1, IFNA1, CCND1
29	doxorubicin32 34 9 9	9.9	KIT, CDKN1B, MMP7, PGR, MKI67, AR
30	thymidine32 18	7.9	KIT, PCNA, RB1, CDKN1B, MKI67, CCND1
31	methotrexate32 34 42 9 9	10.9	COX5A, SERPINE1, CDKN1B, CDKN2A, MKI67, TNF
32	cisplatin32 34 9 9	9.9	MKI67, CCND1, IFNA1, GNRH1, PTGS2, CTSD
33	paclitaxel32 34 9 9	9.9	KIT, PCNA, RB1, CDKN1B, CDKN2A, MKI67
34	5fluorouracil32	6.8	MKI67, IFNA1, GNRH1, ESR1, CTSD, CTNNB1
35	nitric oxide32 9 18 9	9.8	PDGFB, CTSD, COX5A, SERPINE1, PTGS1, PTGS2
36	estradiol32 9 18 9	9.5	PCNA, RB1, SERPINE1, CDKN1B, MKI67, AR
37	steroid32	6.5	CTSD, PGR, DES, ACTC1, WT1, CDKN2A
38	resveratrol32 9 18 9	9.4	CTNNB1, COX5A, PGR, PTGS1, PTGS2, ESR2
39	tamoxifen32 34 9 9	9.4	IGFBP6, IFNA1, GNRH1, ESR1, ESR2, CTSD
40	actinomycin d32	6.0	CDKN2A, AR, IFNA1, GNRH1, ESR1, ESR2
41	estrogen32	5.7	PCNA, IGFBP6, GNRH1, ESR1, ESR2, PTGS1
42	serine32	5.4	KIT, RB1, SERPINE1, CDH2, CDKN1B, CDKN2A
43	dexamethasone32 42 34 9 9	9.3	RB1, COX5A, PDGFB, ACTC1, PGR, CTNNB1
44	retinoic acid32 42 18	7.0	PGR, IFNA1, GNRH1, ESR1, ESR2, TNF
45	testosterone32 9 18 9	8.0	CDKN1B, CDKN2A, MKI67, AR, APC, CCND1
46	cycloheximide32	5.0	TNF, ESR2, ESR1, IFNA1, IGFBP6, CCND1
47	vegf32	4.8	COX5A, PDGFB, PDGFRA, PDGFRB, WT1, ACTC1
48	genistein32 9 18 9	7.8	RB1, AR, PCNA, SERPINE1, CDH2, PGR
49	paraffin32	4.5	S100A1, CTNNB1, PDGFB, PDGFRA, PDGFRB, WT1
50	progesterone32 42 9 18 9	8.2	CDH2, CDKN1B, CDKN2A, MMP7, MKI67, AR

Cellular components related to desmoid tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intrinsic to plasma membrane	GO:031226	10.2	PDGFRA, PDGFRB
2	Axin-APC-beta-catenin-GSK3B complex	GO:034747	10.2	CTNNB1, APC, CTNNBIP1
3	APC-Axin-1-beta-catenin complex	GO:034742	10.1	CTNNB1, APC
4	catenin complex	GO:016342	10.1	CDH2, CTNNA1, CTNNB1
5	cell-cell adherens junction	GO:005913	9.8	APC, CTNNB1, CDH2
6	nucleoplasm	GO:005654	6.5	CDKN2A, PCNA, RB1, CDKN1B, PGR, AR
7	cytoplasm	GO:005737	6.0	ACTC1, PGR, WT1, PDGFRB, PDGFRA, PDGFB
8	nucleus	GO:005634	4.5	PDGFRB, WT1, PGR, AR, PDGFRA, CTNNBIP1

Biological processes related to desmoid tumor according to GeneDecks:

(show all 46)

id	Name	GO ID	Score	Top Affiliating Genes
1	metanephric glomerular mesangial cell proliferation involved in metanephros development	GO:072262	10.5	PDGFB, PDGFRB
2	cardiac myofibril assembly	GO:055003	10.5	ACTC1, PDGFRB, PDGFRA
3	positive regulation of phospholipase C activity	GO:010863	10.5	PDGFRA, KIT, PDGFRB
4	metanephric glomerular capillary formation	GO:072277	10.5	PDGFRB, PDGFRA
5	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	10.4	PDGFRB, PDGFRA
6	platelet-derived growth factor receptor signaling pathway	GO:048008	10.4	PDGFRA, PDGFRB, PDGFB
7	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	GO:035793	10.4	PDGFRB, PDGFB
8	cell chemotaxis	GO:060326	10.4	KIT, PDGFB, PDGFRA, PDGFRB
9	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	10.4	KIT, PDGFRA, PDGFRB, PDGFB
10	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.3	PDGFB, PDGFRA, PDGFRB, KIT
11	peptidyl-tyrosine phosphorylation	GO:018108	10.3	KIT, PDGFB, PDGFRB, PDGFRA
12	positive regulation of muscle cell differentiation	GO:051149	10.3	CTNNA1, CTNNB1, CDH2
13	muscle cell differentiation	GO:042692	10.1	CDH2, CTNNB1, CTNNA1
14	negative regulation of cyclin-dependent protein kinase activity	GO:045736	10.1	CDKN2A, APC, CDKN1B
15	regulation of myelination	GO:031641	10.1	CTNNB1, CDH2
16	cyclooxygenase pathway	GO:019371	10.1	PTGS2, PTGS1
17	regulation of cell proliferation	GO:042127	10.0	PTGS1, MMP7, KIT, SERPINE1
18	positive regulation of cell migration	GO:030335	9.9	APC, PDGFRB, PDGFRA, PDGFB
19	positive regulation of MAPK cascade	GO:043410	9.9	PDGFB, KIT, AR, CDH2
20	positive regulation of mitosis	GO:045840	9.9	PDGFB, TNF, PDGFRB
21	male gonad development	GO:008584	9.9	AR, CTNNA1, WT1, KIT
22	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.9	PDGFRB, PDGFB, PDGFRA, TNF
23	positive regulation of MAP kinase activity	GO:043406	9.7	PDGFRB, PDGFB, TNF
24	phosphatidylinositol-mediated signaling	GO:048015	9.7	CDKN1B, PCNA, PDGFRB, PDGFRA
25	cellular response to organic cyclic compound	GO:071407	9.7	CDKN1B, TNF, CTNNB1
26	G1 phase of mitotic cell cycle	GO:000080	9.6	CDKN1B, RB1, CCND1, CDKN2A
27	positive regulation of smooth muscle cell proliferation	GO:048661	9.6	PDGFRB, TNF, PTGS2, PDGFB
28	response to organic cyclic compound	GO:014070	9.5	PDGFB, CTNNA1, PTGS2, CCND1
29	positive regulation of cell proliferation	GO:008284	9.5	PDGFB, PDGFRB, PDGFRA, AR, KIT, CDKN1B
30	negative regulation of cell growth	GO:030308	9.5	CDKN1B, WT1, ESR2, RB1, CDKN2A
31	response to organic nitrogen	GO:010243	9.4	CCND1, PTGS1, PTGS2
32	response to estrogen stimulus	GO:043627	9.2	ESR1, CCND1, CTNNA1, SERPINE1
33	response to estradiol stimulus	GO:032355	9.2	PDGFB, PTGS2, CTNNB1, ESR1
34	positive regulation of apoptotic process	GO:043065	9.2	ESR2, APC, CTNNB1, PTGS2, TNF
35	S phase of mitotic cell cycle	GO:000084	9.2	CDKN1B, MCM5, RB1, PCNA, CCND1
36	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.0	TNF, ESR1, ESR2, KIT
37	negative regulation of transcription, DNA-dependent	GO:045892	9.0	CDKN2A, TNF, CTNNB1, CDKN1B, RB1, WT1
38	negative regulation of apoptotic process	GO:043066	8.9	TNF, CDKN1B, WT1, CTNNA1, SERPINE1, AR
39	G1/S transition of mitotic cell cycle	GO:000082	8.8	PCNA, CCND1, CDKN1B, CDKN2A, MCM5, RB1
40	positive regulation of transcription, DNA-dependent	GO:045893	8.8	PDGFB, CDKN2A, CTNNB1, TNF, AR, RB1
41	positive regulation of nitric oxide biosynthetic process	GO:045429	8.8	PTGS2, TNF, ESR1
42	response to drug	GO:042493	8.8	PDGFB, TNF, ACTC1, CTNNB1, CCND1, APC
43	mitotic cell cycle	GO:000278	8.7	CDKN1B, CCND1, MCM5, CDKN2A, RB1, PCNA
44	transcription initiation from RNA polymerase II promoter	GO:006367	8.7	AR, ESR1, PGR, ESR2, SERPINE1
45	negative regulation of cell proliferation	GO:008285	8.4	GNRH1, TNF, APC, CDKN1B, CDKN2A, IGFBP6
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.4	CTNNB1, ESR1, AR, CDKN2A, RB1, SERPINE1

Molecular functions related to desmoid tumor according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet-derived growth factor binding	GO:048407	10.3	PDGFB, PDGFRA, PDGFRB
2	platelet-derived growth factor receptor binding	GO:005161	10.2	PDGFRB, PDGFRA, PDGFB
3	vascular endothelial growth factor binding	GO:038085	10.2	PDGFRB, PDGFRA
4	gamma-catenin binding	GO:045295	10.2	CTNNA1, APC, CDH2
5	cadherin binding	GO:045296	10.2	CTNNA1, CTNNB1, APC
6	prostaglandin-endoperoxide synthase activity	GO:004666	9.9	PTGS1, PTGS2
7	estrogen response element binding	GO:034056	9.2	ESR2, ESR1
8	steroid binding	GO:005496	9.2	ESR2, PGR, ESR1
9	estrogen receptor activity	GO:030284	9.0	ESR1, ESR2
10	beta-catenin binding	GO:008013	8.8	AR, APC, ESR1, CTNNA1, CTNNBIP1, CDH2
11	enzyme binding	GO:019899	7.8	CTNNB1, PGR, PTGS2, ESR2, ESR1, AR
12	sequence-specific DNA binding transcription factor activity	GO:003700	7.7	ESR1, ESR2, RB1, WT1, PGR, AR
13	protein binding	GO:005515	4.2	KIT, CDKN1B, CDKN2A, MKI67, AR, APC