MCID: DSM004
MIFTS: 63

Desmoid Tumor malady

Cancer, Muscle, Genetic categories

Summaries for Desmoid Tumor

Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 A desmoid tumor is the abnormal growth of cells in connective tissues, which are tissues that help to maintain the structure of the body and include the tissues covering muscle (fascia), cartilage and fat.  though these tumors have a tendency to invade surrounding tissues and organs (be aggressive), they rarely spread to more distant parts of the body (metastasize).  desmoid tumors occur in 2-5 people per million and are most often found in the muscles of the shoulder or abdominal wall, though they can occur in other parts of the body as well.  the first signs that a desmoid tumor is growing include a growing mass or lump; if the mass presses on other parts of the body, it could cause moderate pain, numbness, tingling, or limit the movement of limbs.  a desmoid tumor is usually diagnosed by magnetic resonance imaging (mri) followed by a biopsy.  treatment consists of surgery to remove as much of the tumor as possible; radiation therapy, chemotherapy, or hormone therapy may also be used to reduce the chance that the tumor might regrow following surgery.  the cause of desmoid tumors is not completely clear;  however, approximately 5% of these tumors are associated with an inherited colon cancer syndrome known as familial adenomatous polyposis (fap). last updated: 10/27/2011

MalaCards: Desmoid Tumor, also known as aggressive fibromatosis, is related to fibromatosis and familial adenomatous polyposis, and has symptoms including early death/lethality, malabsorption/chronic diarrhea/steatorrhea and restricted joint mobility/joint stiffness/ankylosis. An important gene associated with Desmoid Tumor is APC (adenomatous polyposis coli), and among its related pathways are TGF-Beta Pathway and Cardiac Progenitor Differentiation. The compounds cycloheximide and dmpq dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include liver, tongue and lymph node, and related mouse phenotypes are renal/urinary system and vision/eye.

Genetics Home Reference:21 A desmoid tumor is an abnormal growth that arises from connective tissue, which is the tissue that provides strength and flexibility to structures such as bones, ligaments, and muscles. Typically, a single tumor develops, although some people have multiple tumors. The tumors can occur anywhere in the body. Tumors that form in the abdominal wall are called abdominal desmoid tumors; those that arise from the tissue that connects the abdominal organs are called intra-abdominal desmoid tumors; and tumors found in other regions of the body are called extra-abdominal desmoid tumors. Extra-abdominal tumors occur most often in the shoulders, upper arms, and upper legs.

Wikipedia:64 Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors, which are benign,... more...

Description from OMIM:47 135290

Aliases & Classifications for Desmoid Tumor

Sources:
43NIH Rare Diseases, 21Genetics Home Reference, 47OMIM, 45Novoseek, 49Orphanet, 61UMLS, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic
Anatomical: Muscle


Characteristics (Orphanet epidemiological data):

49
desmoid tumor:
Inheritance: Sporadic; Age of onset: Adolescence / Young adulthood; Age of death: Normal


Aliases & Descriptions:

desmoid tumor 43 21 45 49
aggressive fibromatosis 43 21 49
desmoid disease, hereditary 47 61
familial infiltrative fibromatosis 21
musculoaponeurotic fibromatosis 21
hereditary desmoid disease 21
desmoid type fibromatosis 49
fibromatosis, aggressive 61
desmoid fibromatosis 21
deep fibromatosis 21


External Ids:

OMIM47 135290
ICD10 via Orphanet26 D48.1

Related Diseases for Desmoid Tumor

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Desmoid Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1fibromatosis31.3ACTC1, KIT, DES, CTNNB1, APC, PDGFRB
2familial adenomatous polyposis31.2PTGS1, MMP7, CDH2, CTNNB1, APC, COX5A
3adenoma31.2PTGS1, ACTC1, MMP7, CDKN1B, CDH2, MKI67
4gardner syndrome31.0CTNNB1, APC
5gastrointestinal stromal tumor30.5KIT, PDGFRA
6fibrous histiocytoma30.3ACTC1, DES
7neurofibromatosis30.1PDGFRA
8pheochromocytoma30.1CDH2, IGFBP6
9cutaneous fibrous histiocytoma30.1ACTC1, DES, PDGFB, S100A1
10phyllode tumor30.1KIT, MKI67
11wilms tumor30.1ACTC1, DES, CTNNB1, WT1
12papillary carcinoma30.0ACTC1, CDKN1B, MKI67, S100A1
13astrocytoma30.0CDKN1B, CDH2, MKI67, PDGFRA, PDGFRB, PDGFB
14paraganglioma30.0KIT, S100A1
15back pain10.2
16breast reconstruction10.2
17n syndrome10.2
18abdominal wall defect10.2
19desmoid disease, hereditary10.2
20ossifying fibroma10.1
21panhypopituitarism10.1
22diabetes insipidus10.1
23intussusception10.1
24fibromatosis, gingival10.1
25ureteral obstruction10.1
26eosinophilia-myalgia syndrome10.1
27short bowel syndrome10.1
28melorheostosis10.1
29trichinosis10.1
30testicular cancer10.1
31turner syndrome10.1
32attenuated familial adenomatous polyposis10.1
33short syndrome10.1
34sprengel deformity10.1
35enchondroma10.1
36mycobacterium fortuitum10.1
37pleomorphic malignant fibrous histiocytoma10.1
38soft tissue sarcoma10.1
39chronic pain10.1
40insulin resistance10.1
41testicular germ cell tumor10.1
42solitary fibrous tumor10.1
43pleomorphic undifferentiated sarcoma10.1
44craniopharyngioma10.0CTNNB1
45uterine carcinosarcoma10.0KIT
46dermatofibrosarcoma10.0PDGFB
47hepatitis10.0PDGFB
48leydig cell tumor10.0PDGFRB
49germ cell tumors10.0KIT
50pilocytic astrocytoma10.0PDGFRB

Graphical network of the top 20 diseases related to Desmoid Tumor:



Diseases related to desmoid tumor

Clinical Features for Desmoid Tumor

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

135290

Clinical synopsis from OMIM:

135290

Symptoms:

49 (show all 21)
  • early death/lethality
  • malabsorption/chronic diarrhea/steatorrhea
  • restricted joint mobility/joint stiffness/ankylosis
  • retinitis pigmentosa/retinal pigmentary changes
  • articular/joint pain/arthralgia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • thoracic/chest pain
  • myalgia/muscular pain
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • osteolysis/osteoclasia/bone destruction/erosions
  • intestinal obstruction/ileus
  • megaureter/hydronephrosis/pyeloureteral junction syndrome
  • polyposis of the bowel/colon/intestine
  • fibromatosis/bone fibroma
  • muscle anomalies
  • skin tumors/lumps/epidermal cysts
  • sepsis severe/septicemia
  • bladder and ureter anomalies
  • soft tissue sarcoma/cancer/tumor/liposarcoma/myosarcoma
  • anomalies of the abdominal wall

Drugs & Therapeutics for Desmoid Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Desmoid Tumor

Drug clinical trials:

Search ClinicalTrials for Desmoid Tumor

Search NIH Clinical Center for Desmoid Tumor

Search CenterWatch for Desmoid Tumor

Genetic Tests for Desmoid Tumor

Anatomical Context for Desmoid Tumor

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Desmoid Tumor:

33
Liver, Tongue, Lymph node, Lung, Colon, Pancreas, Thyroid, Breast, Prostate, Testis, Testis germ

Animal Models for Desmoid Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Desmoid Tumor:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.4PDGFB, APC, PTGS1
2MP:000539110.2MMP7, APC, CTSD, PDGFB
3MP:000538010.1PDGFB, CTNNBIP1, APC, CDH2
4MP:000538810.0CTNNBIP1, CTNNB1, CDKN1B, PTGS1, PDGFRA
5MP:00107719.9CDKN1B, CTNNB1, APC, PDGFRA, PDGFB
6MP:00053699.8PDGFB, ACTC1, CDH2, WT1, APC, PDGFRA
7MP:00053899.8WT1, APC, PDGFRA, CDKN1B, PTGS1, CTNNB1
8MP:00053909.7CTNNBIP1, PDGFRA, APC
9MP:00053799.7PDGFRB, PDGFRA, WT1, CDKN1B, KIT, PTGS1
10MP:00020069.7PTGS1, CTNNB1, PDGFRA, APC, CDKN1B, MMP7
11MP:00053829.7PDGFRB, KIT, CDKN1B, CTNNB1, CTNNBIP1, APC
12MP:00053709.6PDGFB, APC, WT1, CTNNB1, CDKN1B, KIT
13MP:00053769.6CTSD, CDH2, ACTC1, PTGS1, PDGFRA, PDGFRB
14MP:00036319.6CTSD, CTNNBIP1, APC, PDGFB, KIT, PTGS1
15MP:00030129.6WT1, PDGFRA, APC, CTNNB1, CDKN1B, KIT
16MP:00028739.4S100A1, PDGFRB, PDGFRA, APC, CTNNB1, WT1
17MP:00053819.4CTSD, PTGS1, MMP7, CDKN1B, PDGFRB, KIT
18MP:00053979.3PDGFRB, KIT, CTSD, PDGFB, PTGS1, CDKN1B
19MP:00053879.2PDGFB, PTGS1, MMP7, CDKN1B, CTSD, CTNNB1
20MP:00053869.1DES, KIT, PTGS1, APC, S100A1, PDGFRA
21MP:00053788.9PTGS1, CDKN1B, MMP7, KIT, ACTC1, CDH2
22MP:00053848.9CTSD, CDH2, CDKN1B, MMP7, KIT, ACTC1
23MP:00053858.8PTGS1, S100A1, PDGFB, PDGFRB, PDGFRA, DES
24MP:00107688.6PDGFB, PTGS1, ACTC1, KIT, MMP7, CDKN1B

Publications for Desmoid Tumor

Sources:
51PubMed
See all sources

Articles related to Desmoid Tumor:

(show top 50)    (show all 404)
idTitleAuthorsYear
1
A rare presentation of a large extra-abdominal desmoid tumor of the posterior neck and back. (24035615)
2013
2
Abdominoplasty access for desmoid tumor resection in the rectus abdominis muscle. (23898447)
2013
3
Extra-abdominal periosteal desmoid tumor of the third toe. (24025015)
2013
4
Dramatic and delayed response to Doxorubicin-dacarbazine chemotherapy of a giant desmoid tumor: case report and literature review. (23569447)
2013
5
Desmoid Tumor arising from Omohyoid Muscle: The First Report for Unusual Complication after Trans-axillary Robotic Thyroidectomy. (24115367)
2013
6
Pancreatic solid cystic desmoid tumor: Case report and literature review. (24379602)
2013
7
Immunohistochemical and molecular analysis of tyrosine kinase activity in desmoid tumors. (21195420)
2012
8
Extra-abdominal desmoid tumor with osseous involvement. (22210528)
2012
9
Immunoreactivity for calretinin and keratins in desmoid fibromatosis and other myofibroblastic tumors: a diagnostic pitfall. (22531174)
2012
10
Can combined 18F-FDG-PET and dynamic contrast-enhanced MRI predict behavior of desmoid tumors in patients with familial adenomatous polyposis? (22965401)
2012
11
Successful treatment of an intra-abdominal desmoid tumor with irinotecan, fluorouracil, and leucovorin plus bevacizumab in a patient with familial adenomatous polyposis. (21533592)
2012
12
Desmoid tumor of the anterior abdominal wall in female patients: comparison with endometriosis. (22778752)
2012
13
Reporting an unusual case of mesenteric desmoid tumor. (23198461)
2012
14
Successful combined treatment for giant mesenteric desmoid tumor: case report and review of the literature. (22703821)
2012
15
Activity of Sorafenib against desmoid tumor/deep fibromatosis. (21447727)
2011
16
Familial adenomatous polyposis and desmoid tumors. (22012061)
2011
17
A Case of Gardner's Syndrome Associated with Desmoid Tumor. (21165211)
2010
18
An unusual case of chest wall desmoid tumor. (23133290)
2010
19
A case of mesenteric desmoid tumor of the jejunum. (19942588)
2009
20
Desmoid tumor of the chest wall in an elderly woman. (19830521)
2009
21
Desmoid tumor in the pediatric population: a report of two cases. (19322113)
2009
22
Fibromatosis (desmoid tumor) in the urogenital system. (17900580)
2007
23
Development and rapid growth of a desmoid tumor in the surgical corridor after suboccipital craniotomy for recurrent low-grade astrocytoma. (16645711)
2006
24
Soft-tissue malignant fibrous histiocytoma (high-grade undifferentiated pleomorphic sarcoma) arising in a desmoid tumor in a patient with Milroy's disease. (16437208)
2006
25
Fibromatosis (desmoid tumor) of the breast mimicking a case of ipsilateral metachronous breast cancer. (16925827)
2006
26
Intrathoracic sporadic desmoid tumor with the beta-catenin gene mutation in exon 3 and activated cyclin D1. (16131791)
2006
27
Primary desmoid tumor (extraabdominal fibromatosis) of the breast. (16037525)
2005
28
Response of extraabdominal desmoid tumors to therapy with imatinib mesylate. (12436445)
2002
29
Abdominal wall and foot reconstruction after extensive desmoid tumor resection with free tissue transfer. (11914936)
2002
30
Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). (11313976)
2001
31
Primary fibromatosis of the breast in a patient with multiple desmoid tumors--report of a case with evaluation of estrogen and progesterone receptors. (11770022)
2001
32
Transperitoneal drainage for a large cystic degeneration after regression of an intra-abdominal desmoid tumor. (10826437)
2000
33
Intrathoracic desmoid tumor of the posterior mediastinum with transdiaphragmatic extension. Report of a case. (11218194)
2000
34
Desmoid tumor of the larynx complicating pregnancy: a case report. (10203678)
1999
35
Recurrence of desmoid tumor in a multivisceral transplant patient with Gardner's syndrome. (10232576)
1999
36
Intramuscular desmoid tumor (musculoaponeurotic fibromatosis) in two horses. (10490218)
1999
37
Primary desmoid tumor of the posterior mediastinum. (9930504)
1998
38
Desmoid tumor (fibromatosis) of the breast. A clinician's dilemma--a case report and review. (9108769)
1997
39
Recurring desmoid tumor of the foot: a case study. (8696499)
1996
40
Regression of large pelvic desmoid tumor by tamoxifen and sulindac. (8650880)
1996
41
Desmoid tumor of the breast. (7824633)
1995
42
Case report 771: Melorheostosis in association with desmoid tumor. (8316873)
1993
43
A recurrent pelvic desmoid tumor successfully treated with tamoxifen. (1991311)
1991
44
Graft pseudoaneurysm simulating desmoid tumor recurrence. (2207779)
1990
45
Desmoid tumor complicating remobilization treatment for a chronic pain syndrome. (4004525)
1985
46
Desmoid tumor--review and follow-up of ten cases. (3968891)
1985
47
The desmoid tumor. I. Incidence, sex-, age- and anatomical distribution in the Finnish population. (7091046)
1982
48
Reconstruction of sternal and abdominal wall defects in a case of desmoid tumor. (141547)
1977
49
Desmoid tumor associated with cystosarcoma phyllodes of the breast. (175220)
1976
50
Desmoid tumor of right internal oblique muscle in a patient with trichinosis. (13455361)
1957

Genetic Variations for Desmoid Tumor

Expression for genes affiliated with Desmoid Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Desmoid Tumor

Search GEO for disease gene expression data for Desmoid Tumor.

Pathways for genes affiliated with Desmoid Tumor

Sources:
52QIAGEN, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore, 4Cell Signaling Technology, 53R&D Systems, 30KEGG, 54Reactome
See all sources

Pathways related to Desmoid Tumor according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2MCM5, PDGFB
210.1ACTC1, KIT, PDGFRA
3
Hide members
10.1PDGFRA, KIT, PDGFRB
4
Cytoskeleton remodeling Role of PDGFs in cell migration
Hide members
10.1PDGFRB, PDGFRA, PDGFB
510.1PDGFRA, PDGFB, PDGFRB
610.1PDGFRB, MMP7, PDGFRA
7
Hide members
10.1MMP7, PDGFB, PDGFRA
810.1PDGFRB, CDKN1B, PDGFRA
910.1APC, CTNNB1, CTNNBIP1
1010.0PTGS1, CDKN1B, CTNNB1
1110.0CTNNB1, ACTC1, CDH2
12
Hide members
10.0PDGFB, PDGFRB, APC, PDGFRA
13
Hide members
10.0CTNNB1, PDGFRA, PDGFB, PDGFRB
14
Hide members
9.9APC, CDKN1B, MMP7, CTNNB1
15
Hide members
9.9MMP7, APC, CTNNBIP1, CTNNB1
169.9CTNNB1, APC, MMP7, CDH2
17
Hide members
9.9CDH2, CTNNB1, DES, ACTC1
18
Hide members
9.9PDGFB, PTGS1, PDGFRB, CDKN1B
199.9CDH2, PDGFB, PDGFRB, PDGFRA
20
Hide members
9.9CTNNB1, PDGFRA, PDGFRB, APC, PDGFB
21
Hide members
9.9APC, PDGFRA, CTNNB1, PDGFRB, PDGFB
229.9CTNNB1, PDGFB, PDGFRB, PDGFRA, APC
23
Hide members
9.8PDGFRA, PDGFB, PDGFRB, CTNNB1, KIT
249.8PDGFB, PDGFRB, PDGFRA, APC, CDKN1B
25
Hide members
9.8CTNNB1, PDGFRA, PDGFRB, PDGFB, CDKN1B
26
Hide members
9.8PDGFB, PDGFRB, PDGFRA, CDKN1B, CTNNB1
27
Hide members
9.8KIT, CDKN1B, PDGFRA, PDGFRB, PDGFB
28
Hide members
9.8PDGFRA, KIT, PDGFRB, CDKN1B, PDGFB
29
Hide members
9.8PDGFB, PDGFRB, PDGFRA, CDKN1B, KIT
30
Hide members
9.8PDGFRA, PDGFRB, KIT, PDGFB, CDKN1B
319.8CDKN1B, PDGFRB, PDGFB, PDGFRA, KIT
329.8APC, PDGFRA, CTNNB1, CDKN1B, WT1
339.7CTNNB1, PDGFB, PDGFRA, PDGFRB, APC, CDKN1B
34
Hide members
9.7CTNNB1, CDKN1B, PDGFRA, PDGFRB, CTSD, PDGFB
35
Hide members
9.6PDGFRB, KIT, CDH2, PDGFB, CTNNB1, PDGFRA
369.6CTNNB1, APC, PDGFRA, PDGFRB, CDKN1B, PDGFB
37
Hide members
9.5PDGFB, PDGFRA, APC, KIT, CDH2, CTNNB1
38
Hide members
9.2CDKN1B, APC, PDGFRA, DES, PDGFRB, CDH2

Compounds for genes affiliated with Desmoid Tumor

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Desmoid Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7PDGFB
2dmpq dihydrochloride6010.4PDGFRB, PDGFRA, PDGFB
3sunitinib malate6010.4PDGFRA, PDGFB, PDGFRB
4su 16f6010.4PDGFB, PDGFRB, PDGFRA
5su 66686010.3PDGFB, PDGFRA, PDGFRB
6azoxymethane4510.3CTNNB1, CDKN1B, APC, COX5A
7dexamethasone45 50 29 1113.1CDKN1B, PDGFB, CTNNB1, CDH2
8b 7234510.0ACTC1, CDH2, DES, WT1, S100A1
9hematoxylin4510.0ACTC1, KIT, MKI67, DES, S100A1
10sulindac45 1111.0COX5A, APC, PTGS1, CTNNB1
11paclitaxel45 50 1112.0CDKN1B, PDGFRB, CTNNB1, CTSD
12pkc 4124510.0PDGFRB, PDGFRA, KIT
13silver4510.0MKI67, DES, CTSD, PDGFB, S100A1
14tgf beta14510.0CTNNB1, CDKN1B, PDGFRA, MKI67, PDGFRB, PDGFB
15p0024510.0KIT, MMP7, MKI67, DES, CTSD, CTNNB1
16bromodeoxyuridine4510.0CDKN1B, DES, CTNNB1, PDGFRB, PDGFB, MKI67
17agar459.9PDGFRB, CTNNB1, CTSD, CDKN1B, PTGS1, PDGFB
18biotin45 11 2411.9S100A1, CTNNB1, DES, MKI67, ACTC1
19formaldehyde45 2410.9CTSD, DES, MKI67, ACTC1, KIT, CDKN1B
20celecoxib45 60 29 50 11 2414.9PTGS1, COX5A, APC, CTNNB1, CDKN1B, MKI67
21trastuzumab45 50 1111.9CDKN1B, KIT, CTNNB1, CTSD
225fluorouracil459.9CDKN1B, MKI67, CTSD, CTNNB1, KIT, PDGFRB
23glucose459.9CDH2, APC, MMP7, PDGFRB, ACTC1, CTSD
24ribonucleic acid459.9PDGFRB, WT1, IGFBP6, MMP7, ACTC1, PDGFB
25phosphotyrosine459.9PDGFB, KIT, CDH2, CTNNB1, PDGFRB, PDGFRA
26methionine459.8CTSD, APC, PDGFRB, DES, KIT, CDKN1B
27oxygen45 2410.8PTGS1, MKI67, DES, CTSD, COX5A, CDKN1B
28rapamycin459.8APC, CTNNB1, PDGFRB, CDKN1B, KIT, PDGFRA
29curcumin459.7COX5A, APC, WT1, PTGS1, CTNNB1
30genistein45 29 60 2 11 2414.7PDGFRB, COX5A, CTSD, CTNNB1, CDKN1B, PTGS1
31h2o2459.6PTGS1, COX5A, CTNNB1, CTSD, DES, CDKN1B
32lysine459.6CTSD, CDKN1B, CDH2, MKI67, DES, CTNNB1
33phosphatidylinositol459.6PDGFRA, PDGFRB, KIT, CDKN1B, MMP7, CDH2
34imatinib45 50 1111.5PDGFB, PDGFRB, PDGFRA, WT1, CTNNB1, DES
35glycogen45 2410.5DES, KIT, S100A1, ACTC1, APC, CDKN1B
36threonine459.5KIT, WT1, CDKN1B, PDGFRB, APC, CTNNB1
37doxorubicin45 50 1111.5KIT, CTNNB1, COX5A, MMP7, DES, MKI67
38oligonucleotide459.5KIT, APC, PDGFRB, PDGFRA, WT1, CTNNB1
39serine459.4COX5A, PDGFB, APC, WT1, DES, MKI67
40thymidine45 2410.4WT1, PDGFB, IGFBP6, DES, CTSD, CTNNB1
41testosterone45 60 11 2412.2CTSD, KIT, PDGFRB, CDKN1B, CDH2, MKI67
42cysteine459.1CTSD, DES, CDH2, KIT, CTNNB1, WT1
43nitric oxide45 11 2411.1S100A1, COX5A, PTGS1, KIT, CDKN1B, MMP7
44calcium45 50 11 2412.0S100A1, MKI67, IGFBP6, DES, ACTC1, CTSD
45atp45 299.9PDGFRA, KIT, COX5A, PDGFRB, CTNNB1, CTSD
46tyrosine458.6DES, MKI67, ACTC1, PDGFRB, PDGFRA, APC
47vegf458.6PDGFB, COX5A, MMP7, WT1, CTSD, DES
48paraffin458.5CTNNB1, CTSD, DES, MKI67, CDH2, CDKN1B
49retinoic acid45 249.4MKI67, CDKN1B, KIT, MMP7, IGFBP6, CDH2
50progesterone45 60 29 11 2412.4CTNNB1, WT1, PDGFRB, PDGFB, S100A1, COX5A

GO Terms for genes affiliated with Desmoid Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Desmoid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.2APC, CTNNBIP1, CTNNB1
2intrinsic to plasma membraneGO:03122610.1PDGFRA, PDGFRB
3fascia adherensGO:00591610.1CDH2, DES, CTNNB1
4cell-cell adherens junctionGO:00591310.1APC, CTNNB1, CDH2
5catenin complexGO:0163429.9CTNNB1, CDH2
6cytoplasmGO:0057378.7CTNNB1, PDGFRB, WT1, CTNNBIP1, APC, MKI67
7nucleusGO:0056348.6KIT, MCM5, CDKN1B, MKI67, CTNNB1, CTNNBIP1

Biological processes related to Desmoid Tumor according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular mesangial cell proliferation involved in metanephros developmentGO:07226210.6PDGFRB, PDGFB
2metanephric glomerular capillary formationGO:07227710.6PDGFRA, PDGFRB
3positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathwayGO:03809110.6PDGFRB, PDGFRA
4positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayGO:03579310.6PDGFB, PDGFRB
5positive regulation of phospholipase C activityGO:01086310.5KIT, PDGFRA, PDGFRB
6cardiac myofibril assemblyGO:05500310.5ACTC1, PDGFRA, PDGFRB
7positive regulation of fibroblast growth factor receptor signaling pathwayGO:04574310.5PDGFB, CTNNB1
8metanephric S-shaped body morphogenesisGO:07228410.5WT1, PDGFRB
9retina vasculature development in camera-type eyeGO:06129810.5PDGFRA, PDGFRB
10platelet-derived growth factor receptor signaling pathwayGO:04800810.5PDGFB, PDGFRB, PDGFRA
11negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:06077010.5APC, CDKN1B
12male genitalia developmentGO:03053910.4PDGFRA, WT1, CTNNB1
13positive regulation of DNA biosynthetic processGO:200057310.4PDGFRB, PDGFB
14adrenal gland developmentGO:03032510.4PDGFRB, WT1, PDGFRA
15positive regulation of chemotaxisGO:05092110.4PDGFB, PDGFRB
16cell chemotaxisGO:06032610.4PDGFB, KIT, PDGFRA, PDGFRB
17metanephric mesenchyme developmentGO:07207510.4WT1, PDGFRB
18positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.4PDGFB, PDGFRA, KIT, PDGFRB
19response to estradiol stimulusGO:03235510.4CTNNB1, PDGFRB, PDGFB
20positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.4KIT, PDGFRA, PDGFB, PDGFRB
21peptidyl-tyrosine phosphorylationGO:01810810.4PDGFB, PDGFRB, PDGFRA, KIT
22negative regulation of platelet activationGO:01054410.4PDGFRA, PDGFB
23positive regulation of cell migrationGO:03033510.3PDGFRB, PDGFRA, APC, PDGFB
24positive regulation of calcium ion importGO:09028010.3PDGFRB, PDGFB
25branching involved in ureteric bud morphogenesisGO:00165810.3CTNNBIP1, CTNNB1, WT1
26positive regulation of MAPK cascadeGO:04341010.3KIT, CDH2, CTNNB1, PDGFB
27positive regulation of microtubule polymerizationGO:03111610.3APC, CDKN1B
28positive regulation of smooth muscle cell migrationGO:01491110.2PDGFRB, PDGFB
29phosphatidylinositol-mediated signalingGO:04801510.2PDGFB, PDGFRB, CDKN1B, KIT, PDGFRA
30fibroblast growth factor receptor signaling pathwayGO:00854310.2CDKN1B, PDGFRA, KIT, PDGFRB, PDGFB
31Fc-epsilon receptor signaling pathwayGO:03809510.2KIT, CDKN1B, PDGFRB, PDGFB, PDGFRA
32epidermal growth factor receptor signaling pathwayGO:00717310.2PDGFB, PDGFRB, PDGFRA, CDKN1B, KIT
33neurotrophin TRK receptor signaling pathwayGO:04801110.2PDGFB, PDGFRA, PDGFRB, KIT, CDKN1B
34positive regulation of ERK1 and ERK2 cascadeGO:07037410.1PDGFRB, PDGFRA, PDGFB
35positive regulation of cell proliferationGO:00828410.1PDGFRB, KIT, CDKN1B, PDGFB, PDGFRA
36negative regulation of cell proliferationGO:00828510.0CDKN1B, WT1, APC, CTNNB1, IGFBP6
37innate immune responseGO:04508710.0KIT, CTNNB1, PDGFRA, PDGFRB, PDGFB, CDKN1B
38extracellular matrix organizationGO:0301989.8PDGFB, PDGFRA, CTSD, MMP7
39response to drugGO:0424939.7PDGFB, CTNNB1, MMP7, ACTC1

Molecular functions related to Desmoid Tumor according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:03808510.3PDGFRB, PDGFRA
2platelet-derived growth factor bindingGO:04840710.3PDGFB, PDGFRB, PDGFRA
3platelet-derived growth factor receptor bindingGO:00516110.2PDGFRB, PDGFB, PDGFRA
4gamma-catenin bindingGO:04529510.2CDH2, APC
5protein phosphatase bindingGO:01990310.0CDKN1B, CDH2, CTNNB1
6beta-catenin bindingGO:0080139.9APC, CTNNBIP1, CDH2
7alpha-catenin bindingGO:0452949.9CDH2, CTNNB1
8protein bindingGO:0055158.3WT1, APC, PDGFRA, PDGFRB, PDGFB, S100A1

Products for genes affiliated with Desmoid Tumor

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Desmoid Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet