DIG
MCID: DSM006
MIFTS: 26

Desmoplastic Infantile Ganglioglioma (DIG) malady

Rare diseases category
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Summaries for Desmoplastic Infantile Ganglioglioma

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NIH Rare Diseases:42 Desmoplastic infantile gangliomas (digs) are rare brain tumors that are normally located in the frontal or parietal lobes of the brain. they are usually diagnosed before 18 months of age with most infants presenting with a short duration of symptoms. although seizures are not commonly observed, a bulging fontanelle, rapid head growth, vomiting, and a sunset sign are usually noted. the standard treatment for digs is surgical resection (surgical procedure in which the portion of the brain with the tumor is removed). last updated: 7/30/2013

MalaCards based summary: Desmoplastic Infantile Ganglioglioma, also known as DIG, is related to ganglioglioma and astrocytoma. An important gene associated with Desmoplastic Infantile Ganglioglioma is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog). The compounds valproic acid and agar have been mentioned in the context of this disorder. Affiliated tissues include brain and parietal lobe, and related mouse phenotypes are vision/eye and liver/biliary system.

Aliases & Classifications for Desmoplastic Infantile Ganglioglioma

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Desmoplastic Infantile Ganglioglioma, Aliases & Descriptions:

Name: Desmoplastic Infantile Ganglioglioma 42 62
 
Dig 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Desmoplastic Infantile Ganglioglioma

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Diseases related to Desmoplastic Infantile Ganglioglioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 14)
idRelated DiseaseScoreTop Affiliating Genes
1ganglioglioma11.2
2astrocytoma10.6
3pleomorphic xanthoastrocytoma10.3
4cerebritis10.3
5desmoplastic infantile astrocytoma10.3
6desmoplastic infantile astrocytoma/ganglioglioma10.3
7hepatitis10.0MYCN, CP
8factor v leiden thrombophilia9.9MYCN, CP
9brain cancer9.9MYCN, CP
10non-hodgkin lymphoma9.9MYCN, CP
11burkitt's lymphoma9.9CP, MYCN
12breast cancer9.9MYCN, CP
13colorectal cancer9.8MYCN, CP
14melanoma9.8MYCN, CP

Graphical network of diseases related to Desmoplastic Infantile Ganglioglioma:



Diseases related to desmoplastic infantile ganglioglioma

Symptoms for Desmoplastic Infantile Ganglioglioma

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Drugs & Therapeutics for Desmoplastic Infantile Ganglioglioma

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Drug clinical trials:

Search ClinicalTrials for Desmoplastic Infantile Ganglioglioma

Search NIH Clinical Center for Desmoplastic Infantile Ganglioglioma

Genetic Tests for Desmoplastic Infantile Ganglioglioma

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Anatomical Context for Desmoplastic Infantile Ganglioglioma

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MalaCards organs/tissues related to Desmoplastic Infantile Ganglioglioma:

32
Brain, Parietal lobe

Animal Models for Desmoplastic Infantile Ganglioglioma or affiliated genes

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MGI Mouse Phenotypes related to Desmoplastic Infantile Ganglioglioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.1MYCN, CP
2MP:00053708.8MYCN, CP

Publications for Desmoplastic Infantile Ganglioglioma

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Articles related to Desmoplastic Infantile Ganglioglioma:

(show all 45)
idTitleAuthorsYear
1
Malignant transformation of a desmoplastic infantile ganglioglioma in an infant carrier of a nonsynonymous TP53 mutation. (24768217)
2014
2
Desmoplastic infantile ganglioglioma: Report of an unusual case with a cranial defect. (24891905)
2014
3
Desmoplastic infantile ganglioglioma with late presentation. A clinical, radiological and histopathological analysis*. (24355183)
2013
4
Genome-wide DNA copy number analysis of desmoplastic infantile astrocytomas and desmoplastic infantile gangliogliomas. (23965740)
2013
5
Strong desmin expression in a congenital desmoplastic infantile ganglioglioma mimicking pleomorphic rhadomyosarcoma: a case report including ultrastructural and cytogenetic evaluation and review of the literature. (22899016)
2012
6
Clinical heterogeneity of desmoplastic infantile ganglioglioma: a case series and literature review. (22735886)
2012
7
Malignant transformation of a desmoplastic infantile ganglioglioma. (21763958)
2011
8
Desmoplastic infantile ganglioglioma: Report of a case and review of the literature. (21042508)
2010
9
Imaging of desmoplastic infantile ganglioglioma: a spectroscopic viewpoint. (19139903)
2009
10
Desmoplastic infantile ganglioglioma with a malignant course. (18352812)
2008
11
Desmoplastic infantile ganglioglioma: a report of 2 cases and a review of the literature. (18703892)
2008
12
Desmoplastic infantile ganglioglioma: case report. (19102059)
2008
13
Desmoplastic infantile ganglioglioma/astrocytoma with cerebrospinal metastasis. (17386372)
2007
14
Desmoplastic infantile ganglioglioma: novel aspects in clinical presentation and genetics. (17719974)
2007
15
Desmoplastic infantile ganglioglioma. (17450367)
2007
16
Desmoplastic infantile ganglioglioma with calcification. (16961068)
2006
17
Desmoplastic infantile ganglioglioma. Morphological, immunohistochemical and genetic features. (16623795)
2006
18
Desmoplastic infantile ganglioglioma with high proliferation index: report of a case. (16519002)
2005
19
Desmoplastic Infantile Ganglioglioma: cytologic findings and differential diagnosis on aspiration material. (15644137)
2005
20
Atypical MRI appearance of desmoplastic infantile ganglioglioma. (15900435)
2005
21
Case of desmoplastic infantile ganglioglioma secreting ceruloplasmin. (16417865)
2005
22
Cervico-medullary desmoplastic infantile ganglioglioma: an unusual case with diffuse leptomeningeal dissemination at diagnosis. (15702481)
2005
23
Desmoplastic infantile ganglioglioma: a questionably benign tumour. (16174188)
2005
24
Desmoplastic infantile ganglioglioma: MRI and histological findings case report. (15551129)
2004
25
Desmoplastic infantile ganglioglioma: a rare tumor with an unusual presentation. (15494934)
2004
26
Desmoplastic infantile ganglioglioma -- a case report. (15472436)
2004
27
Desmoplastic infantile ganglioglioma. (12750935)
2003
28
Therapeutic strategies and management of desmoplastic infantile ganglioglioma: two case reports and literature overview. (12783262)
2003
29
Desmoplastic infantile ganglioglioma: a potentially malignant tumor? (12409729)
2002
30
Chronological changes on magnetic resonance images in a case of desmoplastic infantile ganglioglioma. (11818743)
2002
31
Desmoplastic infantile ganglioglioma--clinicopathological and immunohistochemical study of four cases. (12382166)
2002
32
Desmoplastic infantile ganglioglioma (DIG): cranial ultrasound findings. (11436886)
2001
33
Mixed conventional and desmoplastic infantile ganglioglioma: an autopsied case with 6-year follow-up. (11455006)
2001
34
Cytologic features of desmoplastic infantile ganglioglioma: a report of two cases. (11726100)
2001
35
Image interpretation session: 1999. Desmoplastic infantile ganglioglioma. (10682792)
2000
36
Desmoplastic infantile ganglioglioma. (10508884)
1999
37
High amino acid uptake in a low-grade desmoplastic infantile ganglioglioma in a 14-year-old patient. (9584283)
1998
38
Desmoplastic infantile ganglioglioma. (9408160)
1997
39
Telomere associations in desmoplastic infantile ganglioglioma. (8956861)
1996
40
Clinical, radiological and histological findings in desmoplastic infantile ganglioglioma. (7842437)
1994
41
Pleomorphic xanthoastrocytoma and desmoplastic infantile ganglioglioma--have these neoplasms a common origin? (7889337)
1994
42
Desmoplastic infantile ganglioglioma--case report. (7692325)
1993
43
Desmoplastic infantile ganglioglioma with extraparenchymatous cyst--case report. (7683126)
1993
44
Desmoplastic infantile ganglioglioma and desmoplastic cerebral astrocytoma of infancy. (8293187)
1993
45
Desmoplastic infantile ganglioglioma: CT and MR features. (1763751)
1991

Variations for Desmoplastic Infantile Ganglioglioma

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Expression for genes affiliated with Desmoplastic Infantile Ganglioglioma

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Expression patterns in normal tissues for genes affiliated with Desmoplastic Infantile Ganglioglioma

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Pathways for genes affiliated with Desmoplastic Infantile Ganglioglioma

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Compounds for genes affiliated with Desmoplastic Infantile Ganglioglioma

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Sources:
44Novoseek, 50PharmGKB, 24HMDB, 11DrugBank, 28IUPHAR
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Compounds related to Desmoplastic Infantile Ganglioglioma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1valproic acid44 50 24 1112.3MYCN, CP
2agar449.3MYCN, CP
3iron44 2410.2MYCN, CP
4lactate449.2MYCN, CP
5dopamine44 28 24 1112.1CP, MYCN
6serine449.1MYCN, CP
7vegf449.0MYCN, CP
8retinoic acid44 249.8MYCN, CP

GO Terms for genes affiliated with Desmoplastic Infantile Ganglioglioma

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Products for genes affiliated with Desmoplastic Infantile Ganglioglioma

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Sources for Desmoplastic Infantile Ganglioglioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet