MCID: DTR001
MIFTS: 20

Detrusor Sphincter Dyssynergia malady

Aliases & Classifications for Detrusor Sphincter Dyssynergia

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Aliases & Descriptions for Detrusor Sphincter Dyssynergia:

Name: Detrusor Sphincter Dyssynergia 11 13
 
Detrusor and Sphincter Dyssynergia 66

External Ids:

Disease Ontology11 DOID:12145
SNOMED-CT60 236655005
ICD9CM30 596.55

Summaries for Detrusor Sphincter Dyssynergia

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MalaCards based summary: Detrusor Sphincter Dyssynergia, also known as detrusor and sphincter dyssynergia, is related to spinal cord injury and urethritis. An important gene associated with Detrusor Sphincter Dyssynergia is RPS24 (Ribosomal Protein S24). Affiliated tissues include spinal cord.

Related Diseases for Detrusor Sphincter Dyssynergia

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Diseases related to Detrusor Sphincter Dyssynergia via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1spinal cord injury10.8
2urethritis10.7
3spinal cord disease10.3
4multiple system atrophy10.2
5hydronephrosis10.2
6neurogenic bladder10.2
7herpes simplex10.2
8hinman syndrome10.2
9lymphocytic choriomeningitis8.0ATP2B3, LMAN2L, NEXN, RPS24, SLC25A19

Comorbidity relations with Detrusor Sphincter Dyssynergia via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of diseases related to Detrusor Sphincter Dyssynergia:



Diseases related to detrusor sphincter dyssynergia

Symptoms for Detrusor Sphincter Dyssynergia

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Drugs & Therapeutics for Detrusor Sphincter Dyssynergia

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Drugs for Detrusor Sphincter Dyssynergia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholinePhase 275251-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2
DarifenacinPhase 222133099-04-4444031
Synonyms:
(S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
(S)-1-(2-(2,3-dihydro-5-Benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
133099-04-4
2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide
2-{(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide
AC-302
AC1L9FKY
CHEBI:391960
CHEMBL1346
CID444031
D03654
 
DB00496
Darifenacin
Darifenacin (USAN/INN)
Darifenacina
Darifenacinum
Darifénacine
Emselex
Enablex
LS-187359
MolPort-005-943-011
NCGC00168775-01
STOCK6S-73577
darifenacin

Interventional clinical trials:

idNameStatusNCT IDPhase
1Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract DysfunctionNot yet recruitingNCT02859844Phase 3
2Clinical Interest of the Temporary Urethral Stent Allium " Bulbar Urethral Stent " in the Treatment of Detrusor Sphincter DyssynergiaRecruitingNCT02323243Phase 1, Phase 2
3Study of Darifenacin in Patients Suffering From Multiple Sclerosis and Neurogenic Detrusor OveractivityTerminatedNCT00845338Phase 2
4Botox-A Injection to Improve Bladder Function in Early Spinal Cord Injury (#H-20344)TerminatedNCT00711087Phase 2
5Neuro-urological Outcome After Spinal Cord InjuryCompletedNCT01297660
6The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord InjuryNot yet recruitingNCT02573402

Search NIH Clinical Center for Detrusor Sphincter Dyssynergia

Genetic Tests for Detrusor Sphincter Dyssynergia

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Anatomical Context for Detrusor Sphincter Dyssynergia

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MalaCards organs/tissues related to Detrusor Sphincter Dyssynergia:

34
Spinal cord

Animal Models for Detrusor Sphincter Dyssynergia or affiliated genes

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Publications for Detrusor Sphincter Dyssynergia

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Articles related to Detrusor Sphincter Dyssynergia:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Predictors of outcome for urethral injection of botulinum toxin to treat detrusor sphincter dyssynergia in men with spinal cord injury. (27256824)
2016
2
Effects of botulinum toxin A injections in spinal cord injury patients with detrusor overactivity and detrusor sphincter dyssynergia. (27563834)
2016
3
Quick note on tissue engineering-based surgical measures to treat patients with neurogenic bladder-due detrusor/sphincter dyssynergia. (26042661)
2015
4
Therapeutic outcome and quality of life between urethral and detrusor botulinum toxin treatment for patients with spinal cord lesions and detrusor sphincter dyssynergia. (24073977)
2013
5
Diagnosing detrusor sphincter dyssynergia in the neurological patient. (22458490)
2012
6
Transperineal injection of botulinum toxin A for treatment of detrusor sphincter dyssynergia: localization with combined fluoroscopic and electromyographic guidance. (19406304)
2009
7
Urodynamic responses to anal stretch in patients with detrusor sphincter dyssynergia. (18760159)
2008
8
Therapeutic satisfaction and dissatisfaction in patients with spinal cord lesions and detrusor sphincter dyssynergia who received detrusor botulinum toxin a injection. (18533231)
2008
9
Outcome after treatment of detrusor-sphincter dyssynergia by temporary stent. (17471293)
2008
10
Memokath stents for the treatment of detrusor sphincter dyssynergia (DSD) in men with spinal cord injury: the Princess Royal Spinal Injuries Unit 10-year experience. (16520816)
2007
11
Long-term follow-up study of intraurethral stents in spinal cord injured patients with detrusor-sphincter dyssynergia. (17211463)
2007
12
Can neurologic examination predict type of detrusor sphincter-dyssynergia in patients with spinal cord injury? (15708030)
2005
13
Urethral stents for detrusor sphincter dyssynergia. (15679792)
2005
14
Understanding detrusor sphincter dyssynergia--significance of chronology. (16230135)
2005
15
Oral nitric oxide donors: a new pharmacological approach to detrusor-sphincter dyssynergia in spinal cord injured patients? (15041118)
2004
16
Sphincterotomy and the treatment of detrusor-sphincter dyssynergia: current status, future prospects. (12494314)
2003
17
The use of the Memokath stent in the treatment of detrusor sphincter dyssynergia in spinal cord injury patients: a single-centre seven-year experience. (12706000)
2003
18
Treatment of detrusor-sphincter dyssynergia by pudendal nerve block in patients with spinal cord injury. (11994813)
2002
19
Botulinum a toxin and detrusor sphincter dyssynergia: a double-blind lidocaine-controlled study in 13 patients with spinal cord disease. (12121731)
2002
20
A modified biofeedback program for children with detrusor-sphincter dyssynergia: 5-year experience. (11547115)
2001
21
Removal of UroLume endoprosthesis: experience of the North American Study Group for detrusor-sphincter dyssynergia application. (10687974)
2000
22
Biofeedback successfully cures detrusor-sphincter dyssynergia in pediatric patients. (10799231)
2000
23
Clinical significance of detrusor sphincter dyssynergia type in patients with post-traumatic spinal cord injury. (11018603)
2000
24
Bladder leak point pressure: the measure for sphincterotomy success in spinal cord injured patients with external detrusor-sphincter dyssynergia. (9649270)
1998
25
Pediatric case of the day. Hinman syndrome (nonneurogenic bladder [NNNB], detrusor-sphincter dyssynergia). (9460133)
1998
26
Detrusor-sphincter dyssynergia and vesico urethral reflux: management. (9471129)
1998
27
Botulinum A toxin treatment for detrusor-sphincter dyssynergia in spinal cord disease. (9494997)
1998
28
Treatment of detrusor sphincter dyssynergia by transperineal injection of botulinum toxin. (9630155)
1998
29
Balloon dilatation of the external urethral sphincter in the treatment of detrusor-sphincter dyssynergia. (9044516)
1997
30
Use of Memokath temporary urethral stent in treatment of detrusor-sphincter dyssynergia. (9440862)
1997
31
Autonomic dysreflexia and detrusor-sphincter dyssynergia in spinal cord injury patients. (9261785)
1997
32
Botulinum A toxin as a treatment of detrusor-sphincter dyssynergia in patients with spinal cord injury: MRI controlled transperineal injections. (9343126)
1997
33
Detrusor-sphincter dyssynergia induced by cold stimulation of the urinary bladder of rats. (9140030)
1997
34
Detrusor-sphincter dyssynergia. (8711868)
1996
35
Long-term outcome of permanent urethral stents in the treatment of detrusor-sphincter dyssynergia. (8976768)
1996
36
Botulinum-A toxin as a treatment of detrusor-sphincter dyssynergia: a prospective study in 24 spinal cord injury patients. (8583552)
1996
37
Contact neodymium:yttrium-aluminum-garnet laser ablation of the external sphincter in spinal cord injured men with detrusor sphincter dyssynergia. (7771003)
1995
38
Urolume urethral wallstent in the treatment of detrusor sphincter dyssynergia. (7997341)
1994
39
Reduction of detrusor-sphincter dyssynergia during ventral sacral root stimulation: anatomical and electrophysiological experiments. (7719296)
1994
40
Endourethral prosthesis for treatment of detrusor sphincter dyssynergia: impact on quality of life for persons with spinal cord injury. (7777845)
1994
41
Permanent urethral stents for detrusor sphincter dyssynergia. (2021818)
1991
42
Combined transrectal ultrasonography and urodynamics in the evaluation of detrusor-sphincter dyssynergia. (3056566)
1988
43
Effects of botulinum A toxin on detrusor-sphincter dyssynergia in spinal cord injury patients. (3361663)
1988
44
Neuropeptide Y- and vasoactive intestinal polypeptide-containing nerves in the intrinsic external urethral sphincter in the areflexic bladder compared to detrusor-sphincter dyssynergia in patients with spinal cord injury. (3656550)
1987
45
Vesico-ureteral reflux in children with spina bifida and detrusor-sphincter dyssynergia. (6744873)
1984
46
Neurologic aspects of detrusor-sphincter dyssynergia, with reference to the guarding reflex. (7086999)
1982
47
Biomechanical basis for recommendation of transurethral sphincterotomy in spinal-cord-injury patients with detrusor-sphincter dyssynergia. (7278408)
1981
48
Pressor response during cystomanometry in spinal injury patients complicated with detrusor-sphincter dyssynergia. (37349)
1979
49
Detrusor-sphincter dyssynergia. (458950)
1979
50
Anal sphincter stretch: a technique to overcome detrusor-sphincter dyssynergia. (880007)
1977

Variations for Detrusor Sphincter Dyssynergia

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Expression for genes affiliated with Detrusor Sphincter Dyssynergia

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Search GEO for disease gene expression data for Detrusor Sphincter Dyssynergia.

Pathways for genes affiliated with Detrusor Sphincter Dyssynergia

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GO Terms for genes affiliated with Detrusor Sphincter Dyssynergia

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Biological processes related to Detrusor Sphincter Dyssynergia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1translationGO:00064129.2RPS24, SLC25A19

Molecular functions related to Detrusor Sphincter Dyssynergia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of ribosomeGO:00037359.2RPS24, SLC25A19

Sources for Detrusor Sphincter Dyssynergia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet