MCID: DTR001
MIFTS: 21

Detrusor Sphincter Dyssynergia malady

Aliases & Classifications for Detrusor Sphincter Dyssynergia

Aliases & Descriptions for Detrusor Sphincter Dyssynergia:

Name: Detrusor Sphincter Dyssynergia 12 14
Detrusor and Sphincter Dyssynergia 69

External Ids:

Disease Ontology 12 DOID:12145
ICD9CM 35 596.55
SNOMED-CT 64 236655005
UMLS 69 C0341747

Summaries for Detrusor Sphincter Dyssynergia

MalaCards based summary : Detrusor Sphincter Dyssynergia, also known as detrusor and sphincter dyssynergia, is related to spinal cord injury and urethritis. An important gene associated with Detrusor Sphincter Dyssynergia is RPS24 (Ribosomal Protein S24). The drugs Acetylcholine and Darifenacin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord.

Related Diseases for Detrusor Sphincter Dyssynergia

Diseases related to Detrusor Sphincter Dyssynergia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
id Related Disease Score Top Affiliating Genes
1 spinal cord injury 10.7
2 urethritis 10.6
3 spinal cord disease 10.2
4 herpes simplex 10.2
5 multiple system atrophy 10.0
6 mucositis 10.0
7 hydronephrosis 10.0
8 neurogenic bladder 10.0
9 hinman syndrome 10.0
10 chronic recurrent multifocal osteomyelitis 10.0 NEXN PCLO
11 arachnoiditis 8.9 ATP2B3 LMAN2L NEXN PCLO RPS24 SLC25A19

Comorbidity relations with Detrusor Sphincter Dyssynergia via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Detrusor Sphincter Dyssynergia:



Diseases related to Detrusor Sphincter Dyssynergia

Symptoms & Phenotypes for Detrusor Sphincter Dyssynergia

Drugs & Therapeutics for Detrusor Sphincter Dyssynergia

Drugs for Detrusor Sphincter Dyssynergia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 2 51-84-3 187
2
Darifenacin Approved, Investigational Phase 2 133099-04-4 444031
3 Muscarinic Antagonists Phase 2
4 Cholinergic Agents Phase 2
5 Cholinergic Antagonists Phase 2
6 Neuromuscular Agents Phase 2
7 Neurotransmitter Agents Phase 2
8 Peripheral Nervous System Agents Phase 2
9 abobotulinumtoxinA Phase 2
10 incobotulinumtoxinA Phase 2
11 onabotulinumtoxinA Phase 2
12 Botulinum Toxins Phase 2
13 Botulinum Toxins, Type A Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction Recruiting NCT02859844 Phase 3
2 Clinical Interest of the Temporary Urethral Stent Allium " Bulbar Urethral Stent " in the Treatment of Detrusor Sphincter Dyssynergia Completed NCT02323243 Phase 1, Phase 2
3 Study of Darifenacin in Patients Suffering From Multiple Sclerosis and Neurogenic Detrusor Overactivity Terminated NCT00845338 Phase 2
4 Botox-A Injection to Improve Bladder Function in Early Spinal Cord Injury (#H-20344) Terminated NCT00711087 Phase 2
5 Neuro-urological Outcome After Spinal Cord Injury Completed NCT01297660
6 The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord Injury Recruiting NCT02573402

Search NIH Clinical Center for Detrusor Sphincter Dyssynergia

Genetic Tests for Detrusor Sphincter Dyssynergia

Anatomical Context for Detrusor Sphincter Dyssynergia

MalaCards organs/tissues related to Detrusor Sphincter Dyssynergia:

39
Spinal Cord

Publications for Detrusor Sphincter Dyssynergia

Articles related to Detrusor Sphincter Dyssynergia:

(show top 50) (show all 80)
id Title Authors Year
1
Predictors of outcome for urethral injection of botulinum toxin to treat detrusor sphincter dyssynergia in men with spinal cord injury. ( 27256824 )
2016
2
Improvement in detrusor-sphincter dyssynergia by bladder-wall injection of replication-defective herpes simplex virus vector-mediated gene delivery of kynurenine aminotransferase II in spinal cord injury rats. ( 27995942 )
2016
3
Effects of botulinum toxin A injections in spinal cord injury patients with detrusor overactivity and detrusor sphincter dyssynergia. ( 27563834 )
2016
4
Detrusor sphincter dyssynergia: a review of physiology, diagnosis, and treatment strategies. ( 26904418 )
2016
5
Predictors of outcome for urethral injection of botulinum toxin to treat detrusor sphincter dyssynergia in men with spinal cord injury. ( 26712037 )
2015
6
Quick note on tissue engineering-based surgical measures to treat patients with neurogenic bladder-due detrusor/sphincter dyssynergia. ( 26042661 )
2015
7
Long-term outcome of intravesical oxybutynin in children with detrusor-sphincter dyssynergia: With special reference to age-dependent parameters. ( 24436114 )
2014
8
Therapeutic outcome and quality of life between urethral and detrusor botulinum toxin treatment for patients with spinal cord lesions and detrusor sphincter dyssynergia. ( 24073977 )
2013
9
Diagnosing detrusor sphincter dyssynergia in the neurological patient. ( 22458490 )
2012
10
Do Sacral/Peripheral Lesions Contribute to Detrusor-Sphincter Dyssynergia? ( 26676618 )
2012
11
Therapeutic effects of detrusor botulinum toxin A injection on neurogenic detrusor overactivity in patients with different levels of spinal cord injury and types of detrusor sphincter dyssynergia. ( 21243000 )
2011
12
Urodynamic analysis in multiple system atrophy: characterisation of detrusor-sphincter dyssynergia. ( 20683607 )
2010
13
Olfactory mucosal transplantation after spinal cord injury improves voiding efficiency by suppressing detrusor-sphincter dyssynergia in rats. ( 20639055 )
2010
14
Suppression of detrusor-sphincter dyssynergia by herpes simplex virus vector mediated gene delivery of glutamic acid decarboxylase in spinal cord injured rats. ( 20663524 )
2010
15
Transperineal injection of botulinum toxin A for treatment of detrusor sphincter dyssynergia: localization with combined fluoroscopic and electromyographic guidance. ( 19406304 )
2009
16
Therapeutic satisfaction and dissatisfaction in patients with spinal cord lesions and detrusor sphincter dyssynergia who received detrusor botulinum toxin a injection. ( 18533231 )
2008
17
Outcome after treatment of detrusor-sphincter dyssynergia by temporary stent. ( 17471293 )
2008
18
Urodynamic responses to anal stretch in patients with detrusor sphincter dyssynergia. ( 18760159 )
2008
19
Satisfaction with urethral injection of botulinum toxin A for detrusor sphincter dyssynergia in patients with spinal cord lesion. ( 18508331 )
2008
20
Memokath stents for the treatment of detrusor sphincter dyssynergia (DSD) in men with spinal cord injury: the Princess Royal Spinal Injuries Unit 10-year experience. ( 16520816 )
2007
21
Long-term follow-up study of intraurethral stents in spinal cord injured patients with detrusor-sphincter dyssynergia. ( 17211463 )
2007
22
Memokath stents for the treatment of detrusor sphincter dyssynergia (DSD) in men with spinal cord injury: the Princess Royal Spinal Injuries Unit 10-year experience. ( 16044169 )
2006
23
Treatment of detrusor sphincter dyssynergia with baclofen and doxazosin. ( 17124622 )
2006
24
Detrusor-sphincter dyssynergia. ( 17169006 )
2006
25
Understanding detrusor sphincter dyssynergia--significance of chronology. ( 16230135 )
2005
26
Can neurologic examination predict type of detrusor sphincter-dyssynergia in patients with spinal cord injury? ( 15708030 )
2005
27
Placebo controlled, randomised, double blind study of the effects of botulinum A toxin on detrusor sphincter dyssynergia in multiple sclerosis patients. ( 16291892 )
2005
28
Urethral stents for detrusor sphincter dyssynergia. ( 15679792 )
2005
29
Oral nitric oxide donors: a new pharmacological approach to detrusor-sphincter dyssynergia in spinal cord injured patients? ( 15041118 )
2004
30
Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats. ( 14665959 )
2004
31
Urethral stent for the treatment of detrusor-sphincter dyssynergia: evaluation of the clinical, urodynamic, endoscopic and radiological efficacy after more than 1 year. ( 15247742 )
2004
32
The use of the Memokath stent in the treatment of detrusor sphincter dyssynergia in spinal cord injury patients: a single-centre seven-year experience. ( 12706000 )
2003
33
Sphincterotomy and the treatment of detrusor-sphincter dyssynergia: current status, future prospects. ( 12494314 )
2003
34
Treatment of detrusor-sphincter dyssynergia by pudendal nerve block in patients with spinal cord injury. ( 11994813 )
2002
35
Botulinum a toxin and detrusor sphincter dyssynergia: a double-blind lidocaine-controlled study in 13 patients with spinal cord disease. ( 12121731 )
2002
36
A modified biofeedback program for children with detrusor-sphincter dyssynergia: 5-year experience. ( 11547115 )
2001
37
Clinical significance of detrusor sphincter dyssynergia type in patients with post-traumatic spinal cord injury. ( 11018603 )
2000
38
Biofeedback successfully cures detrusor-sphincter dyssynergia in pediatric patients. ( 10799231 )
2000
39
Removal of UroLume endoprosthesis: experience of the North American Study Group for detrusor-sphincter dyssynergia application. ( 10687974 )
2000
40
Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia. ( 10210393 )
1999
41
Pediatric case of the day. Hinman syndrome (nonneurogenic bladder [NNNB], detrusor-sphincter dyssynergia). ( 9460133 )
1998
42
Bladder leak point pressure: the measure for sphincterotomy success in spinal cord injured patients with external detrusor-sphincter dyssynergia. ( 9649270 )
1998
43
Botulinum A toxin treatment for detrusor-sphincter dyssynergia in spinal cord disease. ( 9494997 )
1998
44
Treatment of detrusor sphincter dyssynergia by transperineal injection of botulinum toxin. ( 9630155 )
1998
45
Detrusor-sphincter dyssynergia and vesico urethral reflux: management. ( 9471129 )
1998
46
Use of the Memokath for detrusor-sphincter dyssynergia after spinal cord injury--a cautionary tale. ( 9471137 )
1998
47
Detrusor-sphincter dyssynergia induced by cold stimulation of the urinary bladder of rats. ( 9140030 )
1997
48
Balloon dilatation of the external urethral sphincter in the treatment of detrusor-sphincter dyssynergia. ( 9044516 )
1997
49
Use of Memokath temporary urethral stent in treatment of detrusor-sphincter dyssynergia. ( 9440862 )
1997
50
Botulinum A toxin as a treatment of detrusor-sphincter dyssynergia in patients with spinal cord injury: MRI controlled transperineal injections. ( 9343126 )
1997

Variations for Detrusor Sphincter Dyssynergia

Expression for Detrusor Sphincter Dyssynergia

Search GEO for disease gene expression data for Detrusor Sphincter Dyssynergia.

Pathways for Detrusor Sphincter Dyssynergia

GO Terms for Detrusor Sphincter Dyssynergia

Sources for Detrusor Sphincter Dyssynergia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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