MCID: DTR001
MIFTS: 21

Detrusor Sphincter Dyssynergia malady

Aliases & Classifications for Detrusor Sphincter Dyssynergia

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Aliases & Descriptions for Detrusor Sphincter Dyssynergia:

Name: Detrusor Sphincter Dyssynergia 11 13
 
Detrusor and Sphincter Dyssynergia 68

External Ids:

Disease Ontology11 DOID:12145
SNOMED-CT62 236655005
ICD9CM32 596.55

Summaries for Detrusor Sphincter Dyssynergia

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MalaCards based summary: Detrusor Sphincter Dyssynergia, also known as detrusor and sphincter dyssynergia, is related to spinal cord injury and urethritis. An important gene associated with Detrusor Sphincter Dyssynergia is RPS24 (Ribosomal Protein S24). Affiliated tissues include spinal cord.

Related Diseases for Detrusor Sphincter Dyssynergia

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Diseases related to Detrusor Sphincter Dyssynergia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1spinal cord injury10.7
2urethritis10.6
3spinal cord disease10.2
4herpes simplex10.2
5multiple system atrophy10.0
6mucositis10.0
7hydronephrosis10.0
8neurogenic bladder10.0
9hinman syndrome10.0
10chronic recurrent multifocal osteomyelitis10.0NEXN, PCLO
11arachnoiditis8.9ATP2B3, LMAN2L, NEXN, PCLO, RPS24, SLC25A19

Comorbidity relations with Detrusor Sphincter Dyssynergia via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of diseases related to Detrusor Sphincter Dyssynergia:



Diseases related to detrusor sphincter dyssynergia

Symptoms & Phenotypes for Detrusor Sphincter Dyssynergia

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Drugs & Therapeutics for Detrusor Sphincter Dyssynergia

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Drugs for Detrusor Sphincter Dyssynergia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Darifenacinapproved, investigationalPhase 222133099-04-4444031
Synonyms:
(S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
(S)-1-(2-(2,3-dihydro-5-Benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
133099-04-4
2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide
2-{(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide
AC-302
AC1L9FKY
CHEBI:391960
CHEMBL1346
CID444031
D03654
 
DB00496
Darifenacin
Darifenacin (USAN/INN)
Darifenacina
Darifenacinum
Darifénacine
Emselex
Enablex
LS-187359
MolPort-005-943-011
NCGC00168775-01
STOCK6S-73577
darifenacin
2
AcetylcholineapprovedPhase 280551-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
3incobotulinumtoxinAPhase 2662
4Neuromuscular AgentsPhase 21180
5onabotulinumtoxinAPhase 2652
6Peripheral Nervous System AgentsPhase 223689
7Botulinum Toxins, Type APhase 2657
8Botulinum ToxinsPhase 2697
9Muscarinic AntagonistsPhase 21166
10Neurotransmitter AgentsPhase 218340
11abobotulinumtoxinAPhase 2652
12Cholinergic AgentsPhase 23992
13Cholinergic AntagonistsPhase 21706

Interventional clinical trials:

idNameStatusNCT IDPhase
1Transcutaneous Tibial Nerve Stimulation for Treating Neurogenic Lower Urinary Tract DysfunctionRecruitingNCT02859844Phase 3
2Clinical Interest of the Temporary Urethral Stent Allium " Bulbar Urethral Stent " in the Treatment of Detrusor Sphincter DyssynergiaCompletedNCT02323243Phase 1, Phase 2
3Study of Darifenacin in Patients Suffering From Multiple Sclerosis and Neurogenic Detrusor OveractivityTerminatedNCT00845338Phase 2
4Botox-A Injection to Improve Bladder Function in Early Spinal Cord Injury (#H-20344)TerminatedNCT00711087Phase 2
5Neuro-urological Outcome After Spinal Cord InjuryCompletedNCT01297660
6The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord InjuryRecruitingNCT02573402

Search NIH Clinical Center for Detrusor Sphincter Dyssynergia

Genetic Tests for Detrusor Sphincter Dyssynergia

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Anatomical Context for Detrusor Sphincter Dyssynergia

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MalaCards organs/tissues related to Detrusor Sphincter Dyssynergia:

36
Spinal cord

Publications for Detrusor Sphincter Dyssynergia

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Articles related to Detrusor Sphincter Dyssynergia:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Predictors of outcome for urethral injection of botulinum toxin to treat detrusor sphincter dyssynergia in men with spinal cord injury. (27256824)
2016
2
Improvement in detrusor-sphincter dyssynergia by bladder-wall injection of replication-defective herpes simplex virus vector-mediated gene delivery of kynurenine aminotransferase II in spinal cord injury rats. (27995942)
2016
3
Effects of botulinum toxin A injections in spinal cord injury patients with detrusor overactivity and detrusor sphincter dyssynergia. (27563834)
2016
4
Detrusor sphincter dyssynergia: a review of physiology, diagnosis, and treatment strategies. (26904418)
2016
5
Predictors of outcome for urethral injection of botulinum toxin to treat detrusor sphincter dyssynergia in men with spinal cord injury. (26712037)
2015
6
Quick note on tissue engineering-based surgical measures to treat patients with neurogenic bladder-due detrusor/sphincter dyssynergia. (26042661)
2015
7
Long-term outcome of intravesical oxybutynin in children with detrusor-sphincter dyssynergia: With special reference to age-dependent parameters. (24436114)
2014
8
Therapeutic outcome and quality of life between urethral and detrusor botulinum toxin treatment for patients with spinal cord lesions and detrusor sphincter dyssynergia. (24073977)
2013
9
Diagnosing detrusor sphincter dyssynergia in the neurological patient. (22458490)
2012
10
Do Sacral/Peripheral Lesions Contribute to Detrusor-Sphincter Dyssynergia? (26676618)
2012
11
Therapeutic effects of detrusor botulinum toxin A injection on neurogenic detrusor overactivity in patients with different levels of spinal cord injury and types of detrusor sphincter dyssynergia. (21243000)
2011
12
Urodynamic analysis in multiple system atrophy: characterisation of detrusor-sphincter dyssynergia. (20683607)
2010
13
Olfactory mucosal transplantation after spinal cord injury improves voiding efficiency by suppressing detrusor-sphincter dyssynergia in rats. (20639055)
2010
14
Suppression of detrusor-sphincter dyssynergia by herpes simplex virus vector mediated gene delivery of glutamic acid decarboxylase in spinal cord injured rats. (20663524)
2010
15
Transperineal injection of botulinum toxin A for treatment of detrusor sphincter dyssynergia: localization with combined fluoroscopic and electromyographic guidance. (19406304)
2009
16
Therapeutic satisfaction and dissatisfaction in patients with spinal cord lesions and detrusor sphincter dyssynergia who received detrusor botulinum toxin a injection. (18533231)
2008
17
Outcome after treatment of detrusor-sphincter dyssynergia by temporary stent. (17471293)
2008
18
Urodynamic responses to anal stretch in patients with detrusor sphincter dyssynergia. (18760159)
2008
19
Satisfaction with urethral injection of botulinum toxin A for detrusor sphincter dyssynergia in patients with spinal cord lesion. (18508331)
2008
20
Memokath stents for the treatment of detrusor sphincter dyssynergia (DSD) in men with spinal cord injury: the Princess Royal Spinal Injuries Unit 10-year experience. (16520816)
2007
21
Long-term follow-up study of intraurethral stents in spinal cord injured patients with detrusor-sphincter dyssynergia. (17211463)
2007
22
Memokath stents for the treatment of detrusor sphincter dyssynergia (DSD) in men with spinal cord injury: the Princess Royal Spinal Injuries Unit 10-year experience. (16044169)
2006
23
Treatment of detrusor sphincter dyssynergia with baclofen and doxazosin. (17124622)
2006
24
Detrusor-sphincter dyssynergia. (17169006)
2006
25
Understanding detrusor sphincter dyssynergia--significance of chronology. (16230135)
2005
26
Can neurologic examination predict type of detrusor sphincter-dyssynergia in patients with spinal cord injury? (15708030)
2005
27
Placebo controlled, randomised, double blind study of the effects of botulinum A toxin on detrusor sphincter dyssynergia in multiple sclerosis patients. (16291892)
2005
28
Urethral stents for detrusor sphincter dyssynergia. (15679792)
2005
29
Oral nitric oxide donors: a new pharmacological approach to detrusor-sphincter dyssynergia in spinal cord injured patients? (15041118)
2004
30
Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats. (14665959)
2004
31
Urethral stent for the treatment of detrusor-sphincter dyssynergia: evaluation of the clinical, urodynamic, endoscopic and radiological efficacy after more than 1 year. (15247742)
2004
32
The use of the Memokath stent in the treatment of detrusor sphincter dyssynergia in spinal cord injury patients: a single-centre seven-year experience. (12706000)
2003
33
Sphincterotomy and the treatment of detrusor-sphincter dyssynergia: current status, future prospects. (12494314)
2003
34
Treatment of detrusor-sphincter dyssynergia by pudendal nerve block in patients with spinal cord injury. (11994813)
2002
35
Botulinum a toxin and detrusor sphincter dyssynergia: a double-blind lidocaine-controlled study in 13 patients with spinal cord disease. (12121731)
2002
36
A modified biofeedback program for children with detrusor-sphincter dyssynergia: 5-year experience. (11547115)
2001
37
Clinical significance of detrusor sphincter dyssynergia type in patients with post-traumatic spinal cord injury. (11018603)
2000
38
Biofeedback successfully cures detrusor-sphincter dyssynergia in pediatric patients. (10799231)
2000
39
Removal of UroLume endoprosthesis: experience of the North American Study Group for detrusor-sphincter dyssynergia application. (10687974)
2000
40
Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia. (10210393)
1999
41
Pediatric case of the day. Hinman syndrome (nonneurogenic bladder [NNNB], detrusor-sphincter dyssynergia). (9460133)
1998
42
Bladder leak point pressure: the measure for sphincterotomy success in spinal cord injured patients with external detrusor-sphincter dyssynergia. (9649270)
1998
43
Botulinum A toxin treatment for detrusor-sphincter dyssynergia in spinal cord disease. (9494997)
1998
44
Treatment of detrusor sphincter dyssynergia by transperineal injection of botulinum toxin. (9630155)
1998
45
Detrusor-sphincter dyssynergia and vesico urethral reflux: management. (9471129)
1998
46
Use of the Memokath for detrusor-sphincter dyssynergia after spinal cord injury--a cautionary tale. (9471137)
1998
47
Detrusor-sphincter dyssynergia induced by cold stimulation of the urinary bladder of rats. (9140030)
1997
48
Balloon dilatation of the external urethral sphincter in the treatment of detrusor-sphincter dyssynergia. (9044516)
1997
49
Use of Memokath temporary urethral stent in treatment of detrusor-sphincter dyssynergia. (9440862)
1997
50
Botulinum A toxin as a treatment of detrusor-sphincter dyssynergia in patients with spinal cord injury: MRI controlled transperineal injections. (9343126)
1997

Variations for Detrusor Sphincter Dyssynergia

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Expression for genes affiliated with Detrusor Sphincter Dyssynergia

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Search GEO for disease gene expression data for Detrusor Sphincter Dyssynergia.

Pathways for genes affiliated with Detrusor Sphincter Dyssynergia

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GO Terms for genes affiliated with Detrusor Sphincter Dyssynergia

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Sources for Detrusor Sphincter Dyssynergia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet