MCID: DTR001
MIFTS: 20

Detrusor Sphincter Dyssynergia malady

Aliases & Classifications for Detrusor Sphincter Dyssynergia

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Aliases & Descriptions for Detrusor Sphincter Dyssynergia:

Name: Detrusor Sphincter Dyssynergia 10 12
 
Detrusor and Sphincter Dyssynergia 10 65


External Ids:

Disease Ontology10 DOID:12145
SNOMED-CT59 236655005
ICD9CM29 596.55

Summaries for Detrusor Sphincter Dyssynergia

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MalaCards based summary: Detrusor Sphincter Dyssynergia, also known as detrusor and sphincter dyssynergia, is related to neurogenic bladder and spinal cord injury. An important gene associated with Detrusor Sphincter Dyssynergia is RPS24 (Ribosomal Protein S24). Affiliated tissues include spinal cord.

Related Diseases for Detrusor Sphincter Dyssynergia

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Diseases related to Detrusor Sphincter Dyssynergia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
idRelated DiseaseScoreTop Affiliating Genes
1neurogenic bladder29.4COL6A1, NEXN, P4HB, RPS24, SLC25A19
2spinal cord injury11.0
3urethritis10.9
4spinal cord disease10.6
5greenberg skeletal dysplasia10.4
6multiple system atrophy10.4
7spinal stenosis10.4
8hydronephrosis10.4
9urethral syndrome10.4
10adjustment disorder10.4
11acute cystitis10.4
12herpes simplex10.4
13urethral stricture10.4
14hinman syndrome10.4

Graphical network of diseases related to Detrusor Sphincter Dyssynergia:



Diseases related to detrusor sphincter dyssynergia

Symptoms for Detrusor Sphincter Dyssynergia

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Drugs & Therapeutics for Detrusor Sphincter Dyssynergia

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Drugs for Detrusor Sphincter Dyssynergia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Darifenacinapproved, investigationalPhase 222133099-04-4444031
Synonyms:
(S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
(S)-1-(2-(2,3-dihydro-5-Benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
133099-04-4
2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide
2-{(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide
AC-302
AC1L9FKY
CHEBI:391960
CHEMBL1346
CID444031
D03654
DB00496
 
Darifenacin
Darifenacin (USAN/INN)
Darifenacin Hydrobromide
Darifenacina
Darifenacinum
Darifénacine
Emselex
Enablex
LS-187359
MolPort-005-943-011
NCGC00168775-01
STOCK6S-73577
darifenacin
2Botulinum Toxins, Type APhase 2561
3Botulinum ToxinsPhase 2590

Interventional clinical trials:

idNameStatusNCT IDPhase
1Clinical Interest of the Temporary Urethral Stent Allium " Bulbar Urethral Stent " in the Treatment of Detrusor Sphincter DyssynergiaRecruitingNCT02323243Phase 1, Phase 2
2Study of Darifenacin in Patients Suffering From Multiple Sclerosis and Neurogenic Detrusor OveractivityTerminatedNCT00845338Phase 2
3Botox-A Injection to Improve Bladder Function in Early Spinal Cord Injury (#H-20344)TerminatedNCT00711087Phase 2
4Neuro-urological Outcome After Spinal Cord InjuryCompletedNCT01297660
5The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord InjuryNot yet recruitingNCT02573402

Search NIH Clinical Center for Detrusor Sphincter Dyssynergia

Genetic Tests for Detrusor Sphincter Dyssynergia

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Anatomical Context for Detrusor Sphincter Dyssynergia

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MalaCards organs/tissues related to Detrusor Sphincter Dyssynergia:

33
Spinal cord

Animal Models for Detrusor Sphincter Dyssynergia or affiliated genes

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Publications for Detrusor Sphincter Dyssynergia

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Articles related to Detrusor Sphincter Dyssynergia:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Quick note on tissue engineering-based surgical measures to treat patients with neurogenic bladder-due detrusor/sphincter dyssynergia. (26042661)
2015
2
Therapeutic outcome and quality of life between urethral and detrusor botulinum toxin treatment for patients with spinal cord lesions and detrusor sphincter dyssynergia. (24073977)
2013
3
Diagnosing detrusor sphincter dyssynergia in the neurological patient. (22458490)
2012
4
Therapeutic effects of detrusor botulinum toxin A injection on neurogenic detrusor overactivity in patients with different levels of spinal cord injury and types of detrusor sphincter dyssynergia. (21243000)
2011
5
Urodynamic analysis in multiple system atrophy: characterisation of detrusor-sphincter dyssynergia. (20683607)
2010
6
Transperineal injection of botulinum toxin A for treatment of detrusor sphincter dyssynergia: localization with combined fluoroscopic and electromyographic guidance. (19406304)
2009
7
Outcome after treatment of detrusor-sphincter dyssynergia by temporary stent. (17471293)
2008
8
Urodynamic responses to anal stretch in patients with detrusor sphincter dyssynergia. (18760159)
2008
9
Satisfaction with urethral injection of botulinum toxin A for detrusor sphincter dyssynergia in patients with spinal cord lesion. (18508331)
2008
10
Therapeutic satisfaction and dissatisfaction in patients with spinal cord lesions and detrusor sphincter dyssynergia who received detrusor botulinum toxin a injection. (18533231)
2008
11
Long-term follow-up study of intraurethral stents in spinal cord injured patients with detrusor-sphincter dyssynergia. (17211463)
2007
12
Treatment of detrusor sphincter dyssynergia with baclofen and doxazosin. (17124622)
2006
13
Can neurologic examination predict type of detrusor sphincter-dyssynergia in patients with spinal cord injury? (15708030)
2005
14
Urethral stents for detrusor sphincter dyssynergia. (15679792)
2005
15
Oral nitric oxide donors: a new pharmacological approach to detrusor-sphincter dyssynergia in spinal cord injured patients? (15041118)
2004
16
Sphincterotomy and the treatment of detrusor-sphincter dyssynergia: current status, future prospects. (12494314)
2003
17
Treatment of detrusor-sphincter dyssynergia by pudendal nerve block in patients with spinal cord injury. (11994813)
2002
18
Botulinum a toxin and detrusor sphincter dyssynergia: a double-blind lidocaine-controlled study in 13 patients with spinal cord disease. (12121731)
2002
19
A modified biofeedback program for children with detrusor-sphincter dyssynergia: 5-year experience. (11547115)
2001
20
Removal of UroLume endoprosthesis: experience of the North American Study Group for detrusor-sphincter dyssynergia application. (10687974)
2000
21
Biofeedback successfully cures detrusor-sphincter dyssynergia in pediatric patients. (10799231)
2000
22
Clinical significance of detrusor sphincter dyssynergia type in patients with post-traumatic spinal cord injury. (11018603)
2000
23
Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia. (10210393)
1999
24
Treatment of detrusor sphincter dyssynergia by transperineal injection of botulinum toxin. (9630155)
1998
25
Bladder leak point pressure: the measure for sphincterotomy success in spinal cord injured patients with external detrusor-sphincter dyssynergia. (9649270)
1998
26
Use of the Memokath for detrusor-sphincter dyssynergia after spinal cord injury--a cautionary tale. (9471137)
1998
27
Botulinum A toxin as a treatment of detrusor-sphincter dyssynergia in patients with spinal cord injury: MRI controlled transperineal injections. (9343126)
1997
28
Detrusor-sphincter dyssynergia induced by cold stimulation of the urinary bladder of rats. (9140030)
1997
29
Balloon dilatation of the external urethral sphincter in the treatment of detrusor-sphincter dyssynergia. (9044516)
1997
30
Use of Memokath temporary urethral stent in treatment of detrusor-sphincter dyssynergia. (9440862)
1997
31
Detrusor-sphincter dyssynergia. (8711868)
1996
32
Long-term outcome of permanent urethral stents in the treatment of detrusor-sphincter dyssynergia. (8976768)
1996
33
Botulinum-A toxin as a treatment of detrusor-sphincter dyssynergia: a prospective study in 24 spinal cord injury patients. (8583552)
1996
34
Contact neodymium:yttrium-aluminum-garnet laser ablation of the external sphincter in spinal cord injured men with detrusor sphincter dyssynergia. (7771003)
1995
35
Wallstents in patients with detrusor-sphincter dyssynergia. (7609116)
1995
36
Urolume urethral wallstent in the treatment of detrusor sphincter dyssynergia. (7997341)
1994
37
Reduction of detrusor-sphincter dyssynergia during ventral sacral root stimulation: anatomical and electrophysiological experiments. (7719296)
1994
38
Endourethral prosthesis for treatment of detrusor sphincter dyssynergia: impact on quality of life for persons with spinal cord injury. (7777845)
1994
39
Permanent urethral stents for detrusor sphincter dyssynergia. (2021818)
1991
40
Treatment of detrusor-sphincter dyssynergia with botulinum A toxin: a double-blind study. (2297305)
1990
41
Combined transrectal ultrasonography and urodynamics in the evaluation of detrusor-sphincter dyssynergia. (3056566)
1988
42
Neuropeptide Y- and vasoactive intestinal polypeptide-containing nerves in the intrinsic external urethral sphincter in the areflexic bladder compared to detrusor-sphincter dyssynergia in patients with spinal cord injury. (3656550)
1987
43
Vesico-ureteral reflux in children with spina bifida and detrusor-sphincter dyssynergia. (6744873)
1984
44
Neurologic aspects of detrusor-sphincter dyssynergia, with reference to the guarding reflex. (7086999)
1982
45
Idiopathic detrusor sphincter dyssynergia in neurologically normal patients with voiding abnormalities. (7060614)
1982
46
Biomechanical basis for recommendation of transurethral sphincterotomy in spinal-cord-injury patients with detrusor-sphincter dyssynergia. (7278408)
1981
47
Baclofen in the treatment of detrusor-sphincter dyssynergia in spinal cord injury patients. (7411729)
1980
48
Pressor response during cystomanometry in spinal injury patients complicated with detrusor-sphincter dyssynergia. (37349)
1979
49
Detrusor-sphincter dyssynergia. (458950)
1979
50
A treatment of detrusor-sphincter dyssynergia: pudendal nerve block by phenolglycerin under the guide of direct nerve stimulation. (494454)
1979

Variations for Detrusor Sphincter Dyssynergia

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Expression for genes affiliated with Detrusor Sphincter Dyssynergia

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Search GEO for disease gene expression data for Detrusor Sphincter Dyssynergia.

Pathways for genes affiliated with Detrusor Sphincter Dyssynergia

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GO Terms for genes affiliated with Detrusor Sphincter Dyssynergia

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Cellular components related to Detrusor Sphincter Dyssynergia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum lumenGO:00057889.1COL6A1, P4HB

Biological processes related to Detrusor Sphincter Dyssynergia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:00301989.1COL6A1, P4HB

Sources for Detrusor Sphincter Dyssynergia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet