Developmental Disabilities malady

MedlinePlus: Developmental disabilities are birth defects that cause lifelong problems with how a body part or system works. they include nervous system disabilities affecting how the brain, spinal cord and nervous system function. they cause mental retardation, including down syndrome and fragile x syndrome. they also cause learning and behavioral disorders, such as autism sensory-related disabilities, which can cause vision, hearing and sight problems metabolic disorders such as phenylketonuria, which affect how your body processes the materials it needs to function degenerative disorders such as rett syndrome, which might only become apparent when children are older and can cause physical and mental problems most developmental disabilities have no cure, but you can often treat the symptoms. physical, speech and occupational therapy might help. special education classes and psychological counseling can also help. nih: national institute of child health and human development²³

MalaCards: Developmental Disabilities is related to blindness and iris hypoplasia. An important gene associated with Developmental Disabilities is WHCR (Wolf-Hirschhorn syndrome chromosome region), and among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Development FGF-family signaling. The compounds phenylalanine and hpaii have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord, and related mouse phenotypes are liver/biliary system and respiratory system.

Wikipedia: Developmental disability is a term used in the United States and Canada to describe lifelong...⁴⁴ more...

developmental disabilities 44 17 32 23 43

Diseases related to developmental disabilities by text searches and GeneDecks gene sharing:

(show top 50)    (show all 213)

id	Related Disease	Score	Top Affiliating Genes
1	blindness	26.5	PAFAH1B1, PAX6, SCT, UBE3A, FOXC1, MAOA
2	iris hypoplasia	13.7	PAX6, FOXC1, PITX2
3	axenfeld-rieger syndrome	13.7	PAX6, FOXC1, PITX2
4	renal coloboma syndrome	13.7	PAX2, PITX2
5	cataract-glaucoma	13.6	PAX6, FOXC1, GJA1, PITX2
6	opitz g/bbb syndrome	13.6	MID1, MID2
7	glaucoma, congenital	13.6	PAX6, FOXC1, TYR
8	subcortical laminar heterotopia	13.6	PAFAH1B1, DCX
9	bladder cancer, somatic	13.6	FGFR3, HRAS
10	waardenburg syndrome type 2	13.5	EDNRB, TYR, SOX10
11	cystic kidney	13.5	PAX2, SCT, HNF1B, TSC1
12	ventricular septal defect	13.5	JAG1, GLI1, TBX5, HIRA
13	jackson-weiss syndrome	13.5	FGFR1, FGFR2, FGFR3
14	pulmonary valve stenosis	13.5	JAG1, PTPN11, ELN, HIRA
15	fgfr-related craniosynostosis syndromes	13.5	FGFR1, FGFR2, FGFR3
16	growth disorders	13.5	FGFR3, MECP2, DHCR7
17	osteoglophonic dysplasia	13.5	FGFR1, FGFR2, FGFR3
18	coloboma	13.5	PAX6, PAX2, TBX5, PITX2, SOX10
19	muenke syndrome	13.5	FGFR1, FGFR2, FGFR3
20	osteochondroma	13.5	FGFR1, FGFR3, PTPN11
21	plagiocephaly	13.5	FGFR1, FGFR2, FGFR3
22	shah-waardenburg syndrome	13.5	RET, EDNRB, SOX10
23	crouzonodermoskeletal syndrome	13.4	FGFR2, FGFR3
24	thanatophoric dysplasia	13.4	FGFR2, FGFR3
25	peters anomaly	13.4	PAX6, FOXC1, FOXP2, PITX2
26	crouzon syndrome	13.4	FGFR1, FGFR2, FGFR3
27	acrocephalosyndactylia	13.4	FGFR1, FGFR2, FGFR3
28	lacrimal duct obstruction	13.4	PAX2, SCT, GJA1, EDNRB, ELN
29	hypochondroplasia	13.4	FGFR1, FGFR2, FGFR3
30	colonic aganglionosis	13.4	RET, EDNRB, SOX10
31	disorders of sex development	13.4	FOXL2, NR0B1, SOX10
32	chst3-related skeletal dysplasia	13.4	FGFR1, FGFR2, FGFR3, RMRP
33	craniofacial anomalies	13.4	FOXC1, FGFR2, GJA1, TBX5, DHCR7
34	infantile epileptic encephalopathy	13.4	PAFAH1B1, MECP2, TSC1
35	radioulnar synostosis	13.4	FGFR1, FGFR2, FGFR3
36	cardiofaciocutaneous syndrome	13.4	BRAF, HRAS, PTPN11
37	infectious mononucleosis	13.4	FGFR1, FGFR2, FGFR3
38	pulmonary hypertension	13.4	RHOD, EDNRB, ELN, G6PC
39	craniosynostosis, syndromic	13.4	FGFR1, FGFR2, FGFR3
40	cockayne syndrome	13.3	FGFR1, FGFR2, FGFR3, MECP2
41	polycystic kidney disease	13.3	BRAF, PAX2, HNF1B, TSC1
42	synostosis	13.3	FGFR1, FGFR2, FGFR3, GLI3
43	renal agenesis	13.3	RET, PAX2, SALL1, FGFR1, DHCR7
44	cholestasis	13.3	SCT, JAG1, HNF1B, HNF4A, DHCR7, HADHA
45	x inactivation	13.3	FMR1, MID1, MECP2, HPRT1, NR0B1
46	hyperinsulinism	13.3	LMNA, SCT, HNF1B, HNF4A, G6PC
47	polydactyly	13.3	SALL1, FGFR2, GLI1, GLI3, OFD1, DHCR7
48	hypospadias	13.3	SALL1, FMR1, MID1, MID2, FGFR2
49	aniridia	13.3	PAX6, PAX2, BDNF, FOXC1, HRAS, PITX2
50	costello syndrome	13.3	BRAF, HRAS, PTPN11, ELN

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to developmental disabilities:

²²

MGI Mouse Phenotypes related to developmental disabilities:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	8.9	HNF1B, HADHA, FOXC1, HPRT1, GK, DHCR7
2	respiratory system phenotype	MP:0005388	8.6	PAX6, BDNF, FOXC1, FOXP2, MECP2, GLI3
3	endocrine/exocrine gland phenotype	MP:0005379	8.4	RET, PAFAH1B1, SOX10, TYR, PAX2, FOXL2
4	pigmentation phenotype	MP:0001186	8.4	SOX10, PAX6, BRAF, LMNA, TYR, EDNRB
5	tumorigenesis	MP:0002006	8.1	RET, BRAF, PAX6, GLI1, HRAS, HPRT1
6	limbs/digits/tail phenotype	MP:0005371	7.9	FOXC1, FGFR1, FGFR2, FGFR3, GLI1, GLI3
7	hearing/vestibular/ear phenotype	MP:0005377	7.5	EDNRB, BDNF, PAX2, PAX6, LMNA, SALL1
8	renal/urinary system phenotype	MP:0005367	7.2	HADHA, DHCR7, FGFR2, FGFR1, TSC1, TYR
9	skeleton phenotype	MP:0005390	6.9	FGFR2, FGFR1, FOXC1, JAG1, MECP2, BRAF
10	digestive/alimentary phenotype	MP:0005381	6.7	BRAF, LMNA, RET, PAX6, PTPN11, TPP1
11	vision/eye phenotype	MP:0005391	6.4	RAF1, LMNA, BRAF, FOXC1, PAX6, PAX2
12	integument phenotype	MP:0010771	6.2	GLI3, HRAS, HPRT1, GJA1, TPP1, PTPN11
13	craniofacial phenotype	MP:0005382	6.0	HRAS, HPRT1, GJA1, TPP1, PTPN11, OFD1
14	normal phenotype	MP:0002873	5.9	RET, TBX5, CREBBP, PITX2, G6PC, TYR
15	embryogenesis phenotype	MP:0005380	5.7	RET, BRAF, RAF1, PAX6, PAX2, SALL1
16	behavior/neurological phenotype	MP:0005386	4.3	BRAF, LMNA, PAFAH1B1, PAX6, HRAS, HPRT1
17	nervous system phenotype	MP:0003631	3.5	BRAF, LMNA, RAF1, PAFAH1B1, PAX6, PAX2
18	homeostasis/metabolism phenotype	MP:0005376	INF	RET, BRAF, FGFR2, FGFR3, MECP2, MAOA
19	muscle phenotype	MP:0005369	INF	GJA1, HNF1B, PTPN11, TBX5, CREBBP, PITX2
20	cellular phenotype	MP:0005384	INF	FMR1, PITX2, , EDNRB, TYR, TSC1
21	reproductive system phenotype	MP:0005389	INF	PAX2, PAX6, PAFAH1B1, LMNA, RET, BDNF
22	cardiovascular system phenotype	MP:0005385	INF	RET, BRAF, LMNA, RAF1, PAX6, PAX2
23	mortality/aging	MP:0010768	INF	HTR1A, , EDNRB, G6PC, HIRA, TYR
24	no phenotypic analysis	MP:0003012	INF	GLI1, MECP2, FGFR3, FGFR1, FOXP2, JAG1
25	growth/size phenotype	MP:0005378	INF	FOXP2, NIPBL, PITX2, , EDNRB, G6PC
26	immune system phenotype	MP:0005387	INF	FGFR2, FGFR3, RAF1, BRAF, PAX6, FOXP2

Articles related to developmental disabilities:

id	Title	Authors	Year	Affiliating Genes
1	Monoamine oxidase a promoter gene associated with pro blem behavior in adults with intellectual/developmental disabilities. (19642709)	May M.E.... Kennedy C.H.	2009	MAOA
2	Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities. (18060736)	Griggs B.L.... Srivastava A.K.	2008	DOCK8
3	Secretin is an ineffective treatment for pervasive developmental disabilities: a review of 15 double-blind randomized controlled trials. (15590241)	Sturmey P.	2005	SCT
4	The Colorado mental retardation and developmental disabilities research center. (12175865)	Crnic L.S.	2002	GK, ETFDH
5	Distribution of FMR1 and FMR2 alleles in Javanese individuals with developmental disability and confirmation of a specific AGG-interruption pattern in Asian populations. (11427173)	Faradz S.M.... Holden J.J.	2001	FMR1
6	Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: a case example in developmental disabilities. (10638050)	Faulkner M.S.	1999	HADHA
7	Trinucleotide repeat expansion in the FRAXE locus is not common among institutionalized individuals with non-specific developmental disabilities. (8844096)	Holden J.J.... White B.N.	1996	FMR1

Genes related to developmental disabilities according to GeneCards:

(show top 50)    (show all 58)

id	Symbol	Description	Score	GeneCards Section Context
1	WHCR	Wolf-Hirschhorn syndrome chromosome region	11.0	Summaries
2	RMRP	RNA component of mitochondrial RNA processing endoribonuclease	11.0
3	INPP5J	inositol polyphosphate-5-phosphatase J	11.0
4	FGD1	FYVE, RhoGEF and PH domain containing 1	11.0
5	SALL1	sal-like 1 (Drosophila)	11.0
6	NR0B1	nuclear receptor subfamily 0, group B, member 1	11.0
7	TPP1	tripeptidyl peptidase I	11.0
8	SOX10	SRY (sex determining region Y)-box 10	11.0
9	DHCR7	7-dehydrocholesterol reductase	11.0
10	FOXC1	forkhead box C1	11.0
11	FOXL2	forkhead box L2	11.0
12	OFD1	oral-facial-digital syndrome 1	11.0
13	MID2	midline 2	11.0
14	FMR1	fragile X mental retardation 1	11.0	Publications
15	PAX6	paired box 6	11.0
16	GLI1	GLI family zinc finger 1	11.0
17	PAX2	paired box 2	11.0
18	HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	11.0	Publications
19	G6PC	glucose-6-phosphatase, catalytic subunit	11.0
20	HNF1B	HNF1 homeobox B	11.0
21	PITX2	paired-like homeodomain 2	11.0
22	DCX	doublecortin	11.0
23	JAG1	jagged 1	11.0
24	SCT	secretin	11.0	Publications
25	TBX5	T-box 5	11.0
26	MID1	midline 1 (Opitz/BBB syndrome)	11.0
27	NIPBL	Nipped-B homolog (Drosophila)	11.0
28	PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	11.0
29	PTPN11	protein tyrosine phosphatase, non-receptor type 11	11.0
30	RHOD	ras homolog family member D	11.0
31	ELN	elastin	11.0
32	TSC1	tuberous sclerosis 1	11.0
33	TYR	tyrosinase (oculocutaneous albinism IA)	11.0
34	UBE3A	ubiquitin protein ligase E3A	11.0
35	MECP2	methyl CpG binding protein 2 (Rett syndrome)	11.0
36	HIRA	HIR histone cell cycle regulation defective homolog A (S. cerevisiae)	11.0
37	FGFR1	fibroblast growth factor receptor 1	11.0
38	EDNRB	endothelin receptor type B	11.0
39	GLI3	GLI family zinc finger 3	11.0
40	HNF4A	hepatocyte nuclear factor 4, alpha	11.0
41	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0
42	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0
43	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	11.0
44	LMNA	lamin A/C	11.0
45	FGFR3	fibroblast growth factor receptor 3	11.0
46	GJA1	gap junction protein, alpha 1, 43kDa	11.0
47	FGFR2	fibroblast growth factor receptor 2	11.0
48	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0
49	CREBBP	CREB binding protein	11.0
50	BDNF	brain-derived neurotrophic factor	11.0

Pathways related to developmental disabilities according to GeneDecks:

(show top 50)    (show all 54)

id	Pathway	Score	Top Affiliating Genes
1	Transcriptional Regulatory Network in Embryonic Stem Cell36	10.4	PAX6, HNF4A, SALL1, FOXC1
2	Development FGF-family signaling10	9.9	HRAS, FGFR1, FGFR3, FGFR2, PTPN11
3	Angiogenesis3	9.8	CREBBP, FGFR3, FGFR1, JAG1, FGFR2
4	Development FGFR signaling pathway10	9.8	FGFR1, RAF1, HRAS, PTPN11
5	Development_FGFR signaling pathway41	9.7	RAF1, FGFR1, HRAS, PTPN11
6	Bladder cancer20	9.7	HRAS, FGFR3, RAF1, BRAF
7	Sorafenib Pharmacodynamics34	9.6	RET, BRAF, RAF1, HRAS
8	Development_Prolactin receptor signaling41	9.6	RAF1, CREBBP, HRAS, PTPN11
9	JNK Pathway36	9.6	HRAS, FGFR1, FGFR2, RAF1, FGFR3
10	Development_Neurotrophin family signaling41	9.6	BRAF, RAF1, BDNF, PTPN11, HRAS
11	Development Neurotrophin family signaling10	9.5	BRAF, PTPN11, HRAS, BDNF, RAF1
12	Renal cell carcinoma20	9.5	RAF1, CREBBP, BRAF, PTPN11, HRAS
13	FGF Pathway36	9.5	RAF1, HRAS, FGFR3, FGFR2, FGFR1
14	Melanogenesis20	9.5	TYR, CREBBP, HRAS, EDNRB, RAF1
15	Development Prolactin receptor signaling10	9.5	PTPN11, HRAS, RAF1, CREBBP
16	PPAR Pathway36	9.5	FGFR3, FGFR2, CREBBP, FGFR1, RAF1
17	Activation of cAMP-Dependent PKA36	9.5	FGFR1, FGFR2, RAF1, BDNF
18	Development_FGF-family signaling41	9.5	FGFR1, FGFR2, FGFR3, HRAS, PTPN11, RAF1
19	Pathway_PA16595942534	9.5	HRAS, RET, BRAF, RAF1, FGFR1
20	TGF-beta Signaling Pathways37	9.4	CREBBP, BRAF, HNF4A, GLI3, RAF1
21	Neurotrophin signaling pathway20	9.4	PTPN11, BRAF, RAF1, BDNF, HRAS
22	Pathway_PA16598005034	9.3	FGFR3, FGFR2, FGFR1, RAF1, BRAF, HRAS
23	Insulin signaling pathway20	9.3	BRAF, G6PC, RAF1, HRAS, TSC1
24	Pathways in cancer20	9.3	FGFR1, CREBBP, GLI3, GLI1, FGFR3, RET
25	P2Y Receptor Signaling36	9.3	BRAF, RAF1, FGFR2, FGFR1, FGFR3, HRAS
26	Molecular Mechanisms of Cancer36	9.3	HRAS, SOX10, TSC1, FGFR2, FGFR1, BDNF
27	Prostate cancer20	9.3	FGFR1, CREBBP, HRAS, FGFR2, BRAF, RAF1
28	14-3-3 Induced Intracellular Signaling36	9.2	HRAS, FGFR3, FGFR2, BDNF, TSC1, RAF1
29	Regulation of actin cytoskeleton20	9.2	FGFR2, HRAS, FGFR3, FGFR1, RAF1, BRAF
30	Ras Pathway36	9.2	BRAF, RAF1, FGFR1, FGFR2, FGFR3, HRAS
31	Prolactin Signaling36	9.2	BRAF, CREBBP, HRAS, RAF1
32	Endothelin-1 Signaling Pathway36	9.1	FGFR1, RAF1, BRAF, HRAS, FGFR3, FGFR2
33	Signaling Involved in Cardiac Hypertrophy36	9.0	HRAS, FGFR2, FGFR3, FGFR1, CREBBP, BRAF
34	eIF2 Pathway36	9.0	BDNF, RAF1, BRAF, FGFR1, FGFR2, FGFR3
35	Nanog in Mammalian ESC Pluripotency36	9.0	FGFR2, FGFR1, FGFR3, HRAS, BRAF, BDNF
36	TRKA Signaling36	9.0	BRAF, CREBBP, HRAS, RAF1
37	p70S6K Signaling36	8.9	BDNF, RAF1, CREBBP, HRAS, FGFR3, FGFR1
38	Rap1 Pathway36	8.9	FGFR1, RAF1, HRAS, FGFR3, BRAF, FGFR2
39	Rac1 Pathway36	8.9	HRAS, FGFR3, FGFR2, FGFR1, BDNF, RAF1
40	MAPK signaling pathway20	8.9	HRAS, BRAF, RAF1, BDNF, FGFR1, FGFR2
41	CREB Pathway36	8.9	BDNF, CREBBP, RAF1, FGFR1, FGFR2, FGFR3
42	PTEN Pathway36	8.8	FGFR1, FGFR2, FGFR3, RAF1, BDNF, BRAF
43	GPCR Pathway36	8.8	BRAF, BDNF, RAF1, FGFR2, FGFR3, FGFR1
44	MAPK Family Pathway36	8.8	HRAS, FGFR3, FGFR2, FGFR1, BDNF, RAF1
45	Phospholipase-C Pathway36	8.7	FGFR3, FGFR1, RAF1, BDNF, FGFR2, HRAS
46	ERK Signaling36	8.6	FGFR3, FGFR2, RAF1, BRAF, PAX6, BDNF
47	MAPK Signaling36	8.6	BRAF, RAF1, BDNF, FGFR2, HNF4A, HRAS
48	Activation of PKA through GPCR36	8.6	BDNF, HRAS, BRAF, RAF1, CREBBP, FGFR1
49	JAK-STAT Pathway36	8.6	FGFR1, CREBBP, HRAS, FGFR3, FGFR2, RAF1
50	Estrogen Pathway36	8.5	FGFR1, BRAF, BDNF, UBE3A, RAF1, FGFR2

Compounds related to developmental disabilities according to GeneDecks:

(show top 50)    (show all 80)

id	Compound	Score	Top Affiliating Genes
1	phenylalanine32	10.3	BDNF, FGFR3
2	hpaii32	10.2	MECP2, NR0B1, HPRT1, FMR1
3	lysine32	10.0	EDNRB, HNF4A, SCT, UBE3A, FGFR3
4	pd 16157042	10.0	FGFR2, FGFR1, FGFR3
5	su540232	9.8	FGFR1, FGFR2, FGFR3
6	su 540242	9.5	FGFR3, FGFR2, FGFR1
7	glucose32	9.3	PITX2, FGFR1, HADHA, GLI1, FGFR2, TSC1
8	bromodeoxyuridine32	9.3	PAX6, BDNF, FGFR1, GJA1, HRAS, FGFR2
9	threonine32	9.1	HNF4A, PAX2, RAF1, FGFR1, RET, FGFR3
10	rapamycin32 42	9.9	BRAF, RAF1, FMR1, HRAS, RHOD, ELN
11	methionine32	8.8	GJA1, HRAS, MECP2, FGFR1, PTPN11, BDNF
12	guanine32 9 18 9	11.7	RAF1, SCT, FGFR3, HRAS, HPRT1, RHOD
13	aspartate32	8.6	RET, TYR, RAF1, G6PC, BRAF, ELN
14	phosphoinositide32	8.6	INPP5J, BRAF, RAF1, BDNF, FOXP2, HADHA
15	phosphotyrosine32	8.6	RET, PTPN11, GJA1, HRAS, FGFR3, FGFR1
16	valine32	8.6	HPRT1, HRAS, BDNF, RAF1, BRAF, ELN
17	steroid32	8.6	EDNRB, G6PC, DHCR7, CREBBP, NR0B1, HNF4A
18	adenylate32	8.6	BDNF, SCT, FGFR1, FGFR2, EDNRB, G6PC
19	paraffin32	8.5	FGFR2, TSC1, HRAS, FGFR3, GJA1, ELN
20	zinc32 18	9.5	BDNF, CREBBP, NR0B1, SCT, HNF4A, GLI3
21	thymidine32 18	9.4	BDNF, RAF1, FGFR2, HRAS, HPRT1, GJA1
22	paclitaxel32 34 9 9	11.3	BRAF, FGFR2, FGFR1, BDNF, RAF1, TYR
23	doxorubicin32 34 9 9	11.3	TYR, GJA1, RAF1, BDNF, UBE3A, FGFR2
24	genistein32 9 18 9	11.3	RAF1, TYR, RHOD, FGFR1, FGFR2, GJA1
25	cisplatin32 34 9 9	11.2	TYR, FGFR2, HRAS, GJA1, PTPN11, BDNF
26	agar32	8.2	BDNF, TYR, ELN, PTPN11, GJA1, HRAS
27	cysteine32	8.1	PAFAH1B1, HRAS, TYR, EDNRB, RHOD, PITX2
28	ly29400232	8.1	GJA1, TYR, BRAF, RAF1, BDNF, FOXP2
29	arginine32	8.0	CREBBP, PITX2, RHOD, EDNRB, ELN, TYR
30	oligonucleotide32	8.0	FMR1, PTPN11, HNF4A, RAF1, BRAF, RET
31	oxygen32 18	8.9	GJA1, HRAS, CREBBP, MAOA, FOXP2, TYR
32	dopamine32 9 18 9	10.8	RHOD, TYR, SCT, HPRT1, RET, RAF1
33	dexamethasone32 42 34 9 9	11.8	TYR, RAF1, PTPN11, HNF4A, G6PC, HPRT1
34	pd 98,05932	7.6	RET, CREBBP, FGFR1, FGFR2, BRAF, SCT
35	calcium32 9 18 9	10.4	LMNA, PAFAH1B1, BDNF, BRAF, PTPN11, SCT
36	glutamate32	7.2	GJA1, HPRT1, MAOA, MECP2, FGFR3, FGFR2
37	alanine32	7.1	UBE3A, PTPN11, HADHA, TSC1, TYR, G6PC
38	retinoic acid32 42 18	9.0	RET, GJA1, HNF4A, SCT, BDNF, TBX5
39	atp32	7.0	FGFR2, BRAF, LMNA, BDNF, SCT, UBE3A
40	h2o232	6.9	EDNRB, ELN, FGFR1, FGFR2, MAOA, HRAS
41	testosterone32 9 18 9	9.9	RET, RAF1, BDNF, SCT, FMR1, FGFR1
42	lipid32	6.8	GJA1, HNF4A, BDNF, BRAF, GK, PITX2
43	phosphatidylinositol32	6.8	GLI1, FGFR2, FOXP2, INPP5J, GJA1, HRAS
44	estrogen32	6.7	HRAS, MAOA, GJA1, HNF4A, CREBBP, ELN
45	vegf32	6.7	PAX6, RAF1, BRAF, RET, BDNF, FOXP2
46	serine32	6.2	CREBBP, PITX2, RHOD, EDNRB, TYR, TSC1
47	tyrosine32	6.2	PITX2, RHOD, EDNRB, G6PC, TYR, TSC1
48	forskolin32 42 9 9	INF	FGFR1, BDNF, RAF1, HADHA, FMR1, SCT
49	isoproterenol32 9 9	INF	RAF1, TYR, , CREBBP, GJA1, SCT
50	cyclic amp32 18	INF	RET, GJA1, HRAS, FMR1, SCT, BDNF

Cellular components related to developmental disabilities according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	6.2	FOXL2, FOXP2, FGD1, FGFR1, FGFR2, FOXC1
2	cytoplasm	GO:005737	5.3	HNF4A, GK, HPRT1, HRAS, GLI3, GLI1
3	cytosol	GO:005829	INF	DCX, GLI1, MECP2, FGFR1, FGD1, INPP5J

Biological processes related to developmental disabilities according to GeneDecks:

(show all 32)

id	Name	GO ID	Score	Top Affiliating Genes
1	pituitary gland development	GO:021983	10.5	NR0B1, GLI1, PAX6, SALL1
2	forelimb morphogenesis	GO:035136	10.5	SALL1, TBX5, NIPBL
3	cell fate determination	GO:001709	10.4	JAG1, PAX2, PAX6
4	positive regulation of neuroblast proliferation	GO:002052	10.3	PAX6, SOX10, GLI3
5	regulation of cell migration	GO:030334	10.2	PITX2, LMNA, PAX6, JAG1
6	melanocyte differentiation	GO:030318	10.2	SOX10, EDNRB, GLI3
7	positive regulation of phospholipase activity	GO:010518	10.1	FGFR3, FGFR1, FGFR2
8	enteric nervous system development	GO:048484	10.1	RET, EDNRB, SOX10
9	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	GO:035607	10.1	FGFR1, FGFR2
10	embryonic digestive tract morphogenesis	GO:048557	10.1	FGFR2, GLI3, HNF1B, NIPBL, PITX2
11	lung development	GO:030324	10.1	DHCR7, FGFR2, TBX5, GLI3, GLI1
12	regulation of smoothened signaling pathway	GO:008589	10.1	CREBBP, GLI1, FGFR2
13	positive regulation of cardiac muscle cell proliferation	GO:060045	10.1	FGFR1, TBX5, FGFR2
14	neuron migration	GO:001764	10.0	PAFAH1B1, PAX6, FGFR1, GJA1, DCX, PITX2
15	posterior midgut development	GO:007497	9.9	RET, EDNRB
16	organ morphogenesis	GO:009887	9.8	HRAS, BRAF, FGFR2, ELN, PAX6, FGD1
17	in utero embryonic development	GO:001701	9.7	FGFR2, GLI3, PITX2, SOX10, GJA1, FOXC1
18	heart development	GO:007507	9.7	GLI3, RAF1, SALL1, FOXC1, TBX5, GJA1
19	glucose homeostasis	GO:042593	9.7	PAX6, HNF4A, PTPN11, G6PC
20	ureteric bud development	GO:001657	9.7	SALL1, FGFR2, RET, BDNF, FGFR1
21	negative regulation of transcription, DNA-dependent	GO:045892	9.6	NR0B1, FOXP2, NIPBL, MECP2, PAX2, SALL1
22	positive regulation of MAPK cascade	GO:043410	9.5	FGFR1, HRAS, FGFR3, FGFR2
23	negative regulation of apoptotic process	GO:043066	9.4	PAX2, BRAF, HNF1B, SOX10, RAF1, FGFR1
24	MAPK cascade	GO:000165	9.4	FGFR1, RET, RAF1, FGFR3, HRAS
25	insulin receptor signaling pathway	GO:008286	9.3	FGFR3, RAF1, FGFR1, FGFR2, TSC1, PTPN11
26	axon guidance	GO:007411	9.2	PAX6, FGFR1, PTPN11, RAF1, GLI3, BDNF
27	fibroblast growth factor receptor signaling pathway	GO:008543	9.1	FGFR1, RAF1, FGFR2, FGFR3, HRAS, PTPN11
28	positive regulation of cell proliferation	GO:008284	9.1	FGFR1, FGFR2, MECP2, HTR1A, GLI1, HRAS
29	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.1	SALL1, EDNRB, HNF1B, GLI3, FGFR2, FGFR1
30	negative regulation of cell proliferation	GO:008285	9.0	HRAS, GLI3, FGFR2, GJA1, RAF1, TBX5
31	positive regulation of transcription, DNA-dependent	GO:045893	9.0	PAX6, PAX2, SALL1, TBX5, FOXC1, FOXL2
32	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.7	SOX10, SALL1, FOXC1, FGFR2, GLI1, GLI3

Molecular functions related to developmental disabilities according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	GO:003705	9.9	HNF1B, SOX10, HNF4A, GLI1
2	fibroblast growth factor-activated receptor activity	GO:005007	9.9	FGFR2, FGFR1, FGFR3
3	transcription factor binding	GO:008134	9.6	PITX2, CREBBP, PAX6, FOXC1, MECP2, TBX5
4	fibroblast growth factor binding	GO:017134	9.5	FGFR1, FGFR3, FGFR2
5	sequence-specific DNA binding	GO:043565	9.3	TBX5, HNF4A, HNF1B, GLI3, FOXP2, FOXL2
6	protein homodimerization activity	GO:042803	8.8	PAFAH1B1, FOXP2, FGFR1, FGFR2, HPRT1, HNF1B
7	sequence-specific DNA binding transcription factor activity	GO:003700	8.7	CREBBP, PAX6, SALL1, FOXC1, FOXL2, FOXP2
8	protein binding	GO:005515	3.7	RET, SALL1, UBE3A, PAX2, PAX6, PAFAH1B1