MCID: DVL002
MIFTS: 44

Developmental Disabilities malady

Summaries for Developmental Disabilities

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Developmental disabilities are severe, long-term problems. they may be physical, such as blindness. they may affect mental ability, such as learning disorders. or the problem can be both physical and mental, such as down syndrome. the problems are usually life-long, and can affect everyday living. there are many causes of developmental disabilities, including genetic or chromosome abnormalities. these cause conditions such as down syndrome and rett syndrome. prenatal exposure to substances. drinking alcohol when pregnant can cause fetal alcohol spectrum disorders. certain viral infections during pregnancy preterm birth often there is no cure, but treatment can help the symptoms. treatments include physical, speech, and occupational therapy. special education classes and psychological counseling can also help. nih: national institute of child health and human development

MalaCards: Developmental Disabilities is related to intellectual disability and microcephaly. An important gene associated with Developmental Disabilities is RMRP (RNA component of mitochondrial RNA processing endoribonuclease), and among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Wnt / Hedgehog / Notch. The compounds hpaii and ay 9944 dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and bone, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Wikipedia:63 Developmental disability is a diverse group of severe chronic conditions that are due to mental and/or... more...

Aliases & Classifications for Developmental Disabilities

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63Wikipedia, 44Novoseek, 33MedlinePlus, 60UMLS
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Aliases & Descriptions:

developmental disabilities 63 44 33 60


Related Diseases for Developmental Disabilities

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17GeneCards, 18GeneDecks
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Diseases related to Developmental Disabilities via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1intellectual disability31.4FMR1, DCX, DHCR7, PAX6
2microcephaly30.1PAX6
3breast cancer30.1FOXC1, JAG1, PITX2, NR0B1, GLI1
4autistic disorder29.8FMR1
5autism spectrum disorder10.5
6cerebritis10.3
7cerebral palsy10.3
8learning disability10.2
9obesity10.2
10cervical cancer10.2
11cervicitis10.2
12coffin-siris syndrome10.1
13hepatitis d10.1
14hepatitis10.1
15mood disorder10.1
16substance abuse10.1
17iris hypoplasia and glaucoma10.0FOXC1
18peters plus syndrome10.0PAX6, FOXC1
19moebius syndrome10.0FOXL2
20syndactyly10.0DHCR7
21microphthalmia10.0PAX6, SALL1
22hypospadias10.0MID2
23glaucoma 3, primary congenital, d10.0PAX6, FOXC1
24coloboma10.0PAX6
25eye disease10.0PAX6, PITX2, FOXC1
26aniridia10.0FOXC1, PITX2, PAX6
27polydactyly10.0SALL1, OFD1, GLI1, DHCR7
28congenital heart defect10.0PITX2, JAG1, FOXC1, SALL1
29short stature10.0NR0B1, FGD1, RMRP, FMR1
30blindness10.0FOXC1
31axenfeld-rieger syndrome10.0PITX2, FOXC1
32ovarian disease10.0FMR1, FOXL2
33astrocytoma10.0PAX6
34mental retardation10.0FMR1, FOXC1, DCX, NR0B1, FGD1, DHCR7
35intrahepatic cholestasis10.0JAG1, SCT
36malignant glioma10.0SOX10, G6PC, PITX2, DCX, GLI1, PAX6
37metaphyseal dysplasia10.0RMRP, NR0B1
38premature ovarian failure10.0FOXL2, FMR1
39attention deficit hyperactivity disorder9.9
40speech and communication disorders9.9
41bone fracture9.9
42smith-lemli-opitz syndrome9.9
43neurofibromatosis9.9
44rett syndrome9.9
45bruxism9.9
46williams-beuren syndrome9.9
47angelman syndrome9.9
48costello syndrome9.9
49stereotypic movement disorder9.9
50creatine transporter deficiency9.9

Graphical network of the top 20 diseases related to Developmental Disabilities:



Diseases related to developmental disabilities

Clinical Features for Developmental Disabilities

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Drugs & Therapeutics for Developmental Disabilities

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Developmental Disabilities

Drug clinical trials:

Search ClinicalTrials for Developmental Disabilities

Search NIH Clinical Center for Developmental Disabilities

Search CenterWatch for Developmental Disabilities

Genetic Tests for Developmental Disabilities

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Anatomical Context for Developmental Disabilities

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32MalaCards
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MalaCards organs/tissues related to Developmental Disabilities:

32
Eye, Testes, Bone, Brain, Breast, Skin

Animal Models for Developmental Disabilities or affiliated genes

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36MGI
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Publications for Developmental Disabilities

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50PubMed
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Articles related to Developmental Disabilities:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
The Prevalence of Chromosomal Deletions Relating to Developmental Delay and/or Intellectual Disability in Human Euploid Blastocysts. (24409323)
2014
2
Psychiatric diagnostic screening of social maladaptive behaviour in children with mild intellectual disability: differentiating disordered attachment and pervasive developmental disorder behaviour. (23906477)
2013
3
Trends in menstrual concerns and suppression in adolescents with developmental disabilities. (23763962)
2013
4
Dental treatment of patients with systemic diseases compared to patients with developmental disabilities under general anesthesia. (22229595)
2012
5
Growing health disparities for persons who are aging with intellectual and developmental disabilities: the social work linchpin. (22324333)
2012
6
Enabling people with developmental disabilities to actively perform designated occupational activities according to simple instructions with a Nintendo Wii Remote Controller by controlling environmental stimulation. (22502845)
2012
7
Deprivation, ethnicity and the prevalence of intellectual and developmental disabilities. (20889590)
2012
8
Communication-based assessment of developmental age for young children with developmental disabilities. (22223885)
2012
9
A three-dimensional object orientation detector assisting people with developmental disabilities to control their environmental stimulation through simple occupational activities with a Nintendo Wii Remote Controller. (22119696)
2012
10
Colonoscopy and colorectal cancer screening in adults with intellectual and developmental disabilities: review of a series of cases and recommendations for examination. (23025640)
2012
11
Beyond the call: mothers of children with developmental disabilities responding to sexual abuse. (23194142)
2012
12
Observing signs of pain in relation to self-injurious behaviour among individuals with intellectual and developmental disabilities. (21954901)
2012
13
Children with cochlear implants and developmental disabilities: a language skills study with developmentally matched hearing peers. (21129916)
2011
14
Food preferences in young Dutch children and recommendations for feeding intervention in developmental disabilities. (21227638)
2011
15
Medicaid cuts in health care for persons with developmental disabilities in Tennessee: perspective from the field. (21338313)
2011
16
Replications and extensions in arousal assessment for sex offenders with developmental disabilities. (21709795)
2011
17
Neurological and developmental disabilities in ELBW and VLBW: follow-up at 2 years of age. (20634795)
2011
18
Identification and assessment of children with developmental disabilities in child welfare. (22308662)
2011
19
Stresses and coping strategies of Chinese families with children with autism and other developmental disabilities. (20859670)
2011
20
An object location detector enabling people with developmental disabilities to control environmental stimulation through simple occupational activities with battery-free wireless mice. (21093216)
2011
21
Uncovering health care inequalities among adults with intellectual and developmental disabilities. (21171535)
2010
22
Quality of diabetes care for adults with developmental disabilities. (21122783)
2010
23
Changes in the primary diagnosis of students with intellectual or developmental disabilities ages 6 to 21 receiving special education services 1999 to 2008. (20597736)
2010
24
The effects of multisensory therapy on behaviour of adult clients with developmental disabilities--a systematic review. (19762017)
2010
25
Hospital program for working with adult clients with intellectual and developmental disabilities. (20597748)
2010
26
Assisting people with developmental disabilities improve their collaborative pointing efficiency with a Multiple Cursor Automatic Pointing Assistive Program. (20080383)
2010
27
Conceptualizing community: a comparison of neighborhood characteristics of supportive housing for persons with psychiatric and developmental disabilities. (19251346)
2009
28
Parents' perceptions of postschool years for young adults with developmental disabilities. (19489664)
2009
29
Fostering locomotor behavior of children with developmental disabilities: An overview of studies using treadmills and walkers with microswitches. (18573637)
2009
30
Sexuality issues and gynecologic care of adolescents with developmental disabilities. (19041460)
2008
31
Persons with developmental disabilities exposed to interpersonal violence and crime: strategies and guidance for assessment. (18177273)
2008
32
Predictive factors of early mortality in children with developmental disabilities: a case-comparison analysis. (18184935)
2008
33
Essential fatty acid-deprived tube-fed adults synthesize arachidonic and docosahexaenoic acids: a pilot analysis of the fatty acid status of people with profound developmental disabilities. (18474234)
2008
34
Patient and family advocacy: working with individuals with comorbid mental illness and developmental disabilities and their families. (18726692)
2008
35
Individuals with developmental disabilities and their caregivers. (18924396)
2008
36
Disparities in service utilization and expenditures for individuals with developmental disabilities. (21122729)
2008
37
Effects of an unstable shoe construction on standing balance in children with developmental disabilities: a pilot study. (18985552)
2008
38
Patterns in primary health care utilization among individuals with intellectual and developmental disabilities in Florida. (17887908)
2007
39
Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis. (17621516)
2007
40
The direct support workforce in community supports to individuals with developmental disabilities: issues, implications, and promising practices. (17563893)
2007
41
Clinical genomic psychiatry comes of age in the evaluation and treatment of developmental disabilities: is our nation prepared to make the benefits available to all who need them? (17389114)
2007
42
Recognizing the role of parents in developmental outcomes: a systems approach to evaluating the child with developmental disabilities. (17979203)
2007
43
Primary and secondary effects of parenting and stress management interventions for parents of children with developmental disabilities: a meta-analysis. (17979202)
2007
44
Facilitating the transition of adolescents with developmental disabilities: nursing practice issues and care. (17382848)
2007
45
Further evaluation of emerging speech in children with developmental disabilities: training verbal behavior. (17970258)
2007
46
Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability. (16906163)
2006
47
A critical analysis of the emerging crisis in long-term care for people with developmental disabilities. (17892244)
2005
48
Developmental dyscalculia is a familial learning disability. (15497272)
2001
49
Gross deletions of the neurofibromatosis type 1 (NF1) gene are predominantly of maternal origin and commonly associated with a learning disability, dysmorphic features and developmental delay. (9654211)
1998
50
Trinucleotide repeat expansion in the FRAXE locus is not common among institutionalized individuals with non-specific developmental disabilities. (8844096)
1996

Genetic Variations for Developmental Disabilities

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Expression for genes affiliated with Developmental Disabilities

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Developmental Disabilities

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Pathways for genes affiliated with Developmental Disabilities

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51QIAGEN, 4Cell Signaling Technology
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Pathways related to Developmental Disabilities according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PAX6, FOXC1, SALL1
210.3GLI1, JAG1, FOXC1

Compounds for genes affiliated with Developmental Disabilities

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44Novoseek, 59Tocris Bioscience
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Compounds related to Developmental Disabilities according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hpaii4410.4NR0B1, FMR1
2ay 9944 dihydrochloride5910.2DHCR7, GLI1
3arginine449.7FMR1, SALL1, SCT, G6PC, PITX2, PAX6

GO Terms for genes affiliated with Developmental Disabilities

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16Gene Ontology
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Cellular components related to Developmental Disabilities according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polysomal ribosomeGO:04278810.1NR0B1, FMR1
2cytoplasmGO:0057379.7SALL1, FOXC1, PITX2, NR0B1, MID2, GLI1

Biological processes related to Developmental Disabilities according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1extraocular skeletal muscle developmentGO:00207410.6PITX2, FOXL2
2lacrimal gland developmentGO:03280810.6FOXC1, PAX6
3iris morphogenesisGO:06107210.6PAX6, PITX2
4neuronal stem cell maintenanceGO:09715010.5JAG1, SCT
5pituitary gland developmentGO:02198310.5PAX6, GLI1, NR0B1, SALL1
6regulation of cell migrationGO:03033410.5PAX6, PITX2, JAG1
7cell fate determinationGO:00170910.5PAX6, JAG1
8adrenal gland developmentGO:03032510.4NR0B1, SALL1
9positive regulation of transcription, DNA-dependentGO:04589310.4SALL1, FOXL2, FOXC1, GLI1, PAX6
10neuron migrationGO:00176410.3PITX2, DCX, PAX6
11negative regulation of transcription from RNA polymerase II promoterGO:00012210.3SALL1, FOXL2, FOXC1, PITX2, NR0B1
12digestive tract morphogenesisGO:04854610.3GLI1, SOX10
13central nervous system developmentGO:00741710.3PAX6, DCX, FMR1
14positive regulation of neuroblast proliferationGO:00205210.2SOX10, PAX6
15positive regulation of transcription from RNA polymerase II promoterGO:04594410.2SOX10, SALL1, FOXL2, FOXC1, JAG1, PITX2
16eye developmentGO:00165410.0PAX6, FOXC1

Molecular functions related to Developmental Disabilities according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:03149010.3PITX2, FOXC1
2RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.1SOX10, FOXL2, FOXC1, GLI1
3transcription factor bindingGO:00813410.1PAX6, NR0B1, PITX2, FOXC1, FOXL2, SOX10
4double-stranded DNA bindingGO:00369010.0PAX6, FOXC1, FOXL2

Products for genes affiliated with Developmental Disabilities

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Sources for Developmental Disabilities

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet