MCID: DVL002
MIFTS: 42

Developmental Disabilities malady

Summaries for Developmental Disabilities

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Developmental disabilities are severe, long-term problems. they may be physical, such as blindness. they may affect mental ability, such as learning disorders. or the problem can be both physical and mental, such as down syndrome. the problems are usually life-long, and can affect everyday living. there are many causes of developmental disabilities, including genetic or chromosome abnormalities. these cause conditions such as down syndrome and rett syndrome. prenatal exposure to substances. drinking alcohol when pregnant can cause fetal alcohol spectrum disorders. certain viral infections during pregnancy preterm birth often there is no cure, but treatment can help the symptoms. treatments include physical, speech, and occupational therapy. special education classes and psychological counseling can also help. nih: national institute of child health and human development

MalaCards: Developmental Disabilities is related to mental retardation and microcephaly. An important gene associated with Developmental Disabilities is RMRP (RNA component of mitochondrial RNA processing endoribonuclease), and among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Wnt / Hedgehog / Notch. The compounds hpaii and ay 9944 dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and breast, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Wikipedia:64 Developmental disability is a diverse group of severe chronic conditions that are due to mental and/or... more...

Aliases & Classifications for Developmental Disabilities

Sources:
64Wikipedia, 45Novoseek, 34MedlinePlus, 61UMLS
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Aliases & Descriptions:

developmental disabilities 64 45 34 61


Related Diseases for Developmental Disabilities

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Developmental Disabilities via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1mental retardation30.2DCX, NR0B1, FOXC1, FMR1, DHCR7, PAX6
2microcephaly30.1PAX6
3autistic disorder29.9FMR1
4autism spectrum disorder10.5
5coffin-siris syndrome10.1
6hepatitis d10.1
7substance abuse10.1
8iris hypoplasia and glaucoma10.0FOXC1
9peters plus syndrome10.0PAX6, FOXC1
10moebius syndrome10.0FOXL2
11syndactyly10.0DHCR7
12microphthalmia10.0PAX6, SALL1
13hypospadias10.0MID2
14glaucoma 3, primary congenital, d10.0FOXC1, PAX6
15coloboma10.0PAX6
16eye disease10.0PITX2, FOXC1, PAX6
17aniridia10.0FOXC1, PITX2, PAX6
18polydactyly10.0DHCR7, GLI1, OFD1, SALL1
19congenital heart defect10.0SALL1, PITX2, JAG1, FOXC1
20intellectual disability10.0PAX6, DHCR7, FMR1, DCX
21short stature10.0FGD1, NR0B1, FMR1, RMRP
22blindness10.0FOXC1
23axenfeld-rieger syndrome10.0FOXC1, PITX2
24ovarian disease10.0FMR1, FOXL2
25breast cancer10.0GLI1, FOXC1, PITX2, JAG1, NR0B1
26astrocytoma10.0PAX6
27intrahepatic cholestasis10.0SCT, JAG1
28malignant glioma10.0PITX2, DCX, SOX10, GLI1, PAX6, G6PC
29metaphyseal dysplasia10.0RMRP, NR0B1
30premature ovarian failure10.0FMR1, FOXL2
31attention deficit hyperactivity disorder9.9
32speech and communication disorders9.9
33bone fracture9.9
34smith-lemli-opitz syndrome9.9
35neurofibromatosis9.9
36rett syndrome9.9
37bruxism9.9
38hepatitis c9.9
39williams-beuren syndrome9.9
40angelman syndrome9.9
41hepatitis e9.9
42costello syndrome9.9
43creatine transporter deficiency9.9
44developmental coordination disorder9.9
45blepharophimosis9.9
46congenital nystagmus9.9
47fragile x syndrome9.9
48n syndrome9.9
49osteoporosis9.9
50anxiety disorder9.9

Graphical network of the top 20 diseases related to Developmental Disabilities:



Diseases related to developmental disabilities

Clinical Features for Developmental Disabilities

Drugs & Therapeutics for Developmental Disabilities

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Developmental Disabilities

Drug clinical trials:

Search ClinicalTrials for Developmental Disabilities

Search NIH Clinical Center for Developmental Disabilities

Search CenterWatch for Developmental Disabilities

Genetic Tests for Developmental Disabilities

Anatomical Context for Developmental Disabilities

Sources:
33MalaCards
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MalaCards organs/tissues related to Developmental Disabilities:

33
Skin, Brain, Breast, Fetal brain

Animal Models for Developmental Disabilities or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Developmental Disabilities:

37 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.2DHCR7, SOX10, SALL1, FOXC1, PITX2, OFD1
2MP:000536710.1SALL1, FOXC1, G6PC, JAG1, OFD1, PAX6
3MP:000538110.1SALL1, GLI1, OFD1, PAX6, JAG1, DHCR7
4MP:000537910.1SOX10, FOXC1, PAX6, GLI1, NR0B1, PITX2
5MP:000538010.1GLI1, PAX6, SALL1, FOXC1, JAG1, PITX2
6MP:000287310.0GLI1, PAX6, PITX2, RMRP, JAG1, G6PC
7MP:000539110.0FOXL2, FOXC1, JAG1, PITX2, PAX6, FMR1
8MP:000538210.0PITX2, JAG1, PAX6, DHCR7, FOXC1, OFD1
9MP:000539010.0OFD1, PAX6, PITX2, JAG1, G6PC, FOXC1
10MP:000538910.0FOXL2, PAX6, GLI1, NR0B1, DCX, PITX2
11MP:00053869.9G6PC, PAX6, DHCR7, JAG1, SCT, SALL1
12MP:00053889.9PAX6, GLI1, OFD1, PITX2, FOXC1, DHCR7
13MP:00053849.9FMR1, OFD1, GLI1, PAX6, SOX10, FOXL2
14MP:00011869.9SOX10, PAX6, PITX2, FOXC1
15MP:00036319.8SOX10, GLI1, DCX, OFD1, PITX2, JAG1
16MP:00053789.8FMR1, PITX2, PAX6, DHCR7, GLI1, DCX
17MP:00107689.8SOX10, PAX6, RMRP, SALL1, DHCR7, GLI1

Publications for Developmental Disabilities

Sources:
51PubMed
See all sources

Articles related to Developmental Disabilities:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Utilization patterns of conventional and complementary/alternative treatments in children with autism spectrum disorders and developmental disabilities in a population-based study. (24399100)
2014
2
Brief Report: "Quick and (not so) Dirty" Assessment of Change in Autism: Cross-Cultural Reliability of the Developmental Disabilities CGAS and the OSU Autism CGI. (24379174)
2013
3
The state of the science of employment and economic self-sufficiency for people with intellectual and developmental disabilities. (24303824)
2013
4
Maternal stress, well-being, and impaired sleep in mothers of children with developmental disabilities: a literature review. (24080069)
2013
5
Evaluation of a parent led curriculum in developmental disabilities for pediatric and medicine/pediatric residents. (22987012)
2013
6
Unintentional injuries among youth with developmental disabilities in the United States, 2006-2007. (22757768)
2013
7
Initiatives to reduce the use of seclusion and restraints on people with developmental disabilities: a systematic review and quantitative synthesis. (24025440)
2013
8
Transformation through health teaching for adults with intellectual and developmental disabilities: a qualitative study. (22642967)
2012
9
Demystifying moderators and mediators in intellectual and developmental disabilities research: a primer and review of the literature. (22283834)
2012
10
Growing health disparities for persons who are aging with intellectual and developmental disabilities: the social work linchpin. (22324333)
2012
11
Deprivation, ethnicity and the prevalence of intellectual and developmental disabilities. (20889590)
2012
12
Communication-based assessment of developmental age for young children with developmental disabilities. (22223885)
2012
13
Predicting mental health among mothers of school-aged children with developmental disabilities: the relative contribution of child, maternal and environmental factors. (22699247)
2012
14
A model for pain behavior in individuals with intellectual and developmental disabilities. (22750353)
2012
15
Results from the 2009 Pediatric Rehabilitation Practice survey of the AAPM&R Pediatric Rehabilitation/Developmental Disabilities Council. (21257133)
2011
16
Replications and extensions in arousal assessment for sex offenders with developmental disabilities. (21709795)
2011
17
Neurological and developmental disabilities in ELBW and VLBW: follow-up at 2 years of age. (20634795)
2011
18
Utility of endtidal carbon dioxide monitoring in detection of hypoxia during sedation for brain magnetic resonance imaging in children with developmental disabilities. (21824212)
2011
19
Evidence-based practices in the field of intellectual and developmental disabilities: an international consensus approach. (21167602)
2011
20
Changes in residential arrangements of persons with intellectual and developmental disabilities in the decade following the Olmstead Decision of 1999. (21338314)
2011
21
Adults with intellectual and developmental disabilities and participation in decision making: ethical considerations for professional-client practice. (20597745)
2010
22
Uncovering health care inequalities among adults with intellectual and developmental disabilities. (21171535)
2010
23
Quality of diabetes care for adults with developmental disabilities. (21122783)
2010
24
Low dimensional temporal organization of spontaneous eye blinks in adults with developmental disabilities and stereotyped movement disorder. (19819672)
2010
25
The Drooling Impact Scale: a measure of the impact of drooling in children with developmental disabilities. (19843155)
2010
26
The effects of self-monitoring on the procedural integrity of a behavioral intervention for young children with developmental disabilities. (21119907)
2010
27
Polysomnographic assessment of sleep disturbances in children with developmental disabilities and seizures. (20506030)
2010
28
Increasing the vocal responses of children with autism and developmental disabilities using manual sign mand training and prompt delay. (21541153)
2010
29
Treatment of epilepsy in children with developmental disabilities. (20981762)
2010
30
Assisting people with developmental disabilities improve their collaborative pointing efficiency with a Multiple Cursor Automatic Pointing Assistive Program. (20080383)
2010
31
Oral self-injurious behaviors in patients with developmental disabilities. (19269402)
2009
32
Conceptualizing community: a comparison of neighborhood characteristics of supportive housing for persons with psychiatric and developmental disabilities. (19251346)
2009
33
College: an option for people with intellectual or developmental disabilities. (20198843)
2009
34
Coping strategy use, personality, and adjustment of parents rearing children with developmental disabilities. (19845826)
2009
35
Investigating the acquisition, generalization, and emergence of untrained verbal operants for mands acquired using the picture exchange communication system in adults with severe developmental disabilities. (22477401)
2008
36
Well-being of mid- and later-life mothers of children with developmental disabilities. (18581704)
2008
37
Developmental disabilities, Part II. Preface. (19041455)
2008
38
Effects of ordinary and adaptive toys on pre-school children with developmental disabilities. (17936580)
2008
39
Overweight and obesity among children with developmental disabilities. (18300166)
2008
40
Contriving establishing operations: responses of individuals with developmental disabilities during a learning task. (17420114)
2008
41
Autism: one face of the child with developmental disabilities. (17874667)
2007
42
Evaluation of a methodology for a collaborative multiple source surveillance network for autism spectrum disorders--Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2002. (17287716)
2007
43
Prokinetic therapy reduces aspiration pneumonia in tube-fed patients with severe developmental disabilities. (17963438)
2007
44
Recognizing the role of parents in developmental outcomes: a systems approach to evaluating the child with developmental disabilities. (17979203)
2007
45
Carer reports of health status among adults with intellectual/developmental disabilities in Taiwan living at home and in institutions. (17300413)
2007
46
Prevalence of autism spectrum disorders--autism and developmental disabilities monitoring network, 14 sites, United States, 2002. (17287715)
2007
47
In-home toxic chemical exposures and children with intellectual and developmental disabilities. (17256300)
2006
48
Fine motor deficiencies in children with developmental coordination disorder and learning disabilities: an underlying open-loop control deficit. (14624830)
2003
49
Tardive dyskinesia associated with metoclopramide in persons with developmental disabilities. (12102590)
2002
50
Developmental disabilities associated with congenital nystagmus. (1719034)
1991

Genetic Variations for Developmental Disabilities

Expression for genes affiliated with Developmental Disabilities

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Developmental Disabilities

Search GEO for disease gene expression data for Developmental Disabilities.

Pathways for genes affiliated with Developmental Disabilities

Sources:
52QIAGEN, 4Cell Signaling Technology
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Pathways related to Developmental Disabilities according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PAX6, FOXC1, SALL1
210.3GLI1, JAG1, FOXC1

Compounds for genes affiliated with Developmental Disabilities

Sources:
45Novoseek, 60Tocris Bioscience
See all sources

Compounds related to Developmental Disabilities according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hpaii4510.4NR0B1, FMR1
2ay 9944 dihydrochloride6010.2DHCR7, GLI1
3arginine459.7FMR1, SALL1, SCT, G6PC, PITX2, PAX6

GO Terms for genes affiliated with Developmental Disabilities

Sources:
16Gene Ontology
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Cellular components related to Developmental Disabilities according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polysomal ribosomeGO:04278810.1NR0B1, FMR1
2cytoplasmGO:0057379.7SALL1, FOXC1, PITX2, NR0B1, MID2, GLI1

Biological processes related to Developmental Disabilities according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1extraocular skeletal muscle developmentGO:00207410.6PITX2, FOXL2
2lacrimal gland developmentGO:03280810.6FOXC1, PAX6
3iris morphogenesisGO:06107210.6PAX6, PITX2
4neuronal stem cell maintenanceGO:09715010.5JAG1, SCT
5pituitary gland developmentGO:02198310.5PAX6, GLI1, NR0B1, SALL1
6regulation of cell migrationGO:03033410.5PAX6, PITX2, JAG1
7cell fate determinationGO:00170910.5PAX6, JAG1
8adrenal gland developmentGO:03032510.4NR0B1, SALL1
9positive regulation of transcription, DNA-dependentGO:04589310.4SALL1, FOXL2, FOXC1, GLI1, PAX6
10neuron migrationGO:00176410.3PITX2, DCX, PAX6
11negative regulation of transcription from RNA polymerase II promoterGO:00012210.3SALL1, FOXL2, FOXC1, PITX2, NR0B1
12digestive tract morphogenesisGO:04854610.3GLI1, SOX10
13central nervous system developmentGO:00741710.3PAX6, DCX, FMR1
14positive regulation of neuroblast proliferationGO:00205210.2SOX10, PAX6
15positive regulation of transcription from RNA polymerase II promoterGO:04594410.2SOX10, SALL1, FOXL2, FOXC1, JAG1, PITX2
16eye developmentGO:00165410.0PAX6, FOXC1

Molecular functions related to Developmental Disabilities according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:03149010.3PITX2, FOXC1
2RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.1SOX10, FOXL2, FOXC1, GLI1
3transcription factor bindingGO:00813410.1PAX6, NR0B1, PITX2, FOXC1, FOXL2, SOX10
4double-stranded DNA bindingGO:00369010.0PAX6, FOXC1, FOXL2

Products for genes affiliated with Developmental Disabilities

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  • Antibodies

Sources for Developmental Disabilities

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet