MCID: DVL002
MIFTS: 39

Developmental Disabilities malady

Mental diseases category

Summaries for Developmental Disabilities

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Developmental disabilities are severe, long-term problems. they may be physical, such as blindness. they may affect mental ability, such as learning disorders. or the problem can be both physical and mental, such as down syndrome. the problems are usually life-long, and can affect everyday living. there are many causes of developmental disabilities, including genetic or chromosome abnormalities. these cause conditions such as down syndrome and rett syndrome. prenatal exposure to substances. drinking alcohol when pregnant can cause fetal alcohol spectrum disorders. certain viral infections during pregnancy preterm birth often there is no cure, but treatment can help the symptoms. treatments include physical, speech, and occupational therapy. special education classes and psychological counseling can also help. nih: national institute of child health and human development

MalaCards: Developmental Disabilities is related to mental retardation and autism spectrum disorder. An important gene associated with Developmental Disabilities is RMRP (RNA component of mitochondrial RNA processing endoribonuclease), and among its related pathways is Transcriptional Regulatory Network in Embryonic Stem Cell. The compounds acth and zinc have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and bone, and related mouse phenotypes are normal and limbs/digits/tail.

Wikipedia:66 Developmental disability is a diverse group of severe chronic conditions that are due to mental and/or... more...

Aliases & Classifications for Developmental Disabilities

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Sources:
66Wikipedia, 46Novoseek, 35MedlinePlus, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

developmental disabilities 66 46 35 63


Related Diseases for Developmental Disabilities

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Developmental Disabilities:



Diseases related to developmental disabilities

Symptoms for Developmental Disabilities

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Drugs & Therapeutics for Developmental Disabilities

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Developmental Disabilities

Drug clinical trials:

Search ClinicalTrials for Developmental Disabilities

Search NIH Clinical Center for Developmental Disabilities

Search CenterWatch for Developmental Disabilities

Genetic Tests for Developmental Disabilities

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Anatomical Context for Developmental Disabilities

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Sources:
34MalaCards
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MalaCards organs/tissues related to Developmental Disabilities:

34
Eye, Brain, Bone, Testes, Breast, Skin

Animal Models for Developmental Disabilities or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Developmental Disabilities:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.7RMRP, FOXL2, FOXC1, SALL1
2MP:00053718.4SALL1, FOXC1, OFD1
3MP:00107688.0RMRP, OFD1, FOXL2, FOXC1, SALL1

Publications for Developmental Disabilities

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Sources:
53PubMed
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Articles related to Developmental Disabilities:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Working memory demands of aided augmentative and alternative communication for individuals with developmental disabilities. (23902430)
2013
2
Brief Report: "Quick and (not so) Dirty" Assessment of Change in Autism: Cross-Cultural Reliability of the Developmental Disabilities CGAS and the OSU Autism CGI. (24379174)
2013
3
Depression risks in mothers of children with developmental disabilities: a cross-cultural comparison of Brazil, Colombia, Malaysia and Thailand. (22408120)
2013
4
Teaching skills related to self-employment to adults with developmental disabilities: an analog analysis. (23702598)
2013
5
Use of prevention and prevention plus weight management guidelines for youth with developmental disabilities living in group homes. (23414975)
2013
6
The state of the science of employment and economic self-sufficiency for people with intellectual and developmental disabilities. (24303824)
2013
7
An evaluation of the EQUIP treatment programme with men who have intellectual or other developmental disabilities. (23281218)
2013
8
Families of individuals with intellectual and developmental disabilities: policy, funding, services, and experiences. (24303822)
2013
9
Relationships between leisure participation and quality of life of people with developmental disabilities. (23613480)
2013
10
Evaluation of an activities of daily living scale for adolescents and adults with developmental disabilities. (23260606)
2013
11
Commentary: Filling out the evidence base for treatment of attention-deficit hyperactivity disorder symptoms in children with intellectual and developmental disability: conclusions for clinicians--a response to Simonoff et al. (2013). (23692250)
2013
12
A snapshot of North Carolina's public mental health, developmental disabilities, and substance abuse service system. (22779165)
2012
13
A wireless object location detector enabling people with developmental disabilities to control environmental stimulation through simple occupational activities with Nintendo Wii Balance Boards. (22502821)
2012
14
Transformation through health teaching for adults with intellectual and developmental disabilities: a qualitative study. (22642967)
2012
15
Availing services for developmental disabilities: parental experiences from a referral center in developing country. (22180300)
2012
16
Minimizing health risks among older adults with intellectual and/or developmental disabilities: clinical considerations to promote quality of life. (22587644)
2012
17
Self-report computer-based survey of technology use by people with intellectual and developmental disabilities. (22316226)
2012
18
Nutrition and food skills education for adults with developmental disabilities. (21382225)
2011
19
Fetal and infant spontaneous general movements as predictors of developmental disabilities. (23362029)
2011
20
Jobs by 21 partnership project: impact of cross-system collaboration on employment outcomes of young adults with developmental disabilities. (21721980)
2011
21
Children with cochlear implants and developmental disabilities: a language skills study with developmentally matched hearing peers. (21129916)
2011
22
A functional analysis of gestural behaviors emitted by young children with severe developmental disabilities. (22532763)
2011
23
Food preferences in young Dutch children and recommendations for feeding intervention in developmental disabilities. (21227638)
2011
24
Trends in the prevalence of developmental disabilities in US children, 1997-2008. (21606152)
2011
25
Prevalence of developmental disabilities and receipt of special education services among children with an inborn error of metabolism. (19914633)
2010
26
Nursing perspectives on cancer screening in adults with intellectual and other developmental disabilities. (20722477)
2010
27
Maladaptive behaviors are linked with inefficient sleep in individuals with developmental disabilities. (20700513)
2010
28
Caregiving for children with developmental disabilities is associated with a poor antibody response to influenza vaccination. (19297308)
2009
29
Assisting people with developmental disabilities to improve pointing efficiency with an Automatic Pointing Assistive Program. (19447580)
2009
30
Successful transitions for people with intellectual and other developmental disabilities. (20198837)
2009
31
Developmental disabilities: challenges for research practices and policies in the 21st century. (19563583)
2009
32
Sexuality issues and gynecologic care of adolescents with developmental disabilities. (19041460)
2008
33
Investigating the acquisition, generalization, and emergence of untrained verbal operants for mands acquired using the picture exchange communication system in adults with severe developmental disabilities. (22477401)
2008
34
Abusive head trauma in infants and young children: a unique contributor to developmental disabilities. (19041457)
2008
35
How well do care providers know the children with developmental disabilities they care for? (18394106)
2008
36
Increased risk of injury in children with developmental disabilities. (17582739)
2008
37
Persons with developmental disabilities exposed to interpersonal violence and crime: strategies and guidance for assessment. (18177273)
2008
38
Well-being of mid- and later-life mothers of children with developmental disabilities. (18581704)
2008
39
Parent training for young children with developmental disabilities: randomized controlled trial. (18702556)
2008
40
Predictive factors of early mortality in children with developmental disabilities: a case-comparison analysis. (18184935)
2008
41
Early intervention and prevention of self-injurious behaviour exhibited by young children with developmental disabilities. (18173568)
2008
42
Diagnosis and treatment of mood disorders in adults with developmental disabilities. (18726158)
2008
43
Adults with developmental disabilities. Guidance for quality clinical care. (19998931)
2007
44
Federal family and disability policy: special relevance for developmental disabilities. (17563894)
2007
45
Patterns in primary health care utilization among individuals with intellectual and developmental disabilities in Florida. (17887908)
2007
46
Predictors of care-giver stress in families of preschool-aged children with developmental disabilities. (17217475)
2007
47
Therapeutic approaches to developmental disabilities in young children. (17824270)
2007
48
Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis. (17621516)
2007
49
The Colorado mental retardation and developmental disabilities research center. (12175865)
2002
50
Menstrually related mood disorder in developmentally disabled adolescents: review and current status. (3042295)
1988

Variations for Developmental Disabilities

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Expression for genes affiliated with Developmental Disabilities

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Developmental Disabilities

Search GEO for disease gene expression data for Developmental Disabilities.

Pathways for genes affiliated with Developmental Disabilities

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Sources:
51PathCards, 54QIAGEN
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Pathways related to Developmental Disabilities according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5FOXC1, SALL1

Compounds for genes affiliated with Developmental Disabilities

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46Novoseek, 25HMDB
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Compounds related to Developmental Disabilities according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1acth469.4NR0B1, SCT
2zinc46 259.6NR0B1, SALL1, SCT

GO Terms for genes affiliated with Developmental Disabilities

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Sources:
17Gene Ontology
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Biological processes related to Developmental Disabilities according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1ovarian follicle developmentGO:0015419.9FOXL2, FOXC1
2regulation of sequence-specific DNA binding transcription factor activityGO:0510909.8FOXC1, FOXL2
3pattern specification processGO:0073899.8FOXL2, FOXC1
4ureteric bud developmentGO:0016579.7FOXC1, SALL1
5adrenal gland developmentGO:0303259.6NR0B1, SALL1
6pituitary gland developmentGO:0219839.6SALL1, NR0B1
7gonad developmentGO:0084069.6SALL1, NR0B1
8heart developmentGO:0075079.5FOXC1, SALL1
9kidney developmentGO:0018229.4FOXC1, SALL1
10positive regulation of transcription, DNA-templatedGO:0458939.2SALL1, FOXC1, FOXL2
11negative regulation of transcription, DNA-templatedGO:0458929.0NR0B1, FOXL2, SALL1
12positive regulation of transcription from RNA polymerase II promoterGO:0459448.9FOXL2, FOXC1, SALL1
13negative regulation of transcription from RNA polymerase II promoterGO:0001228.8NR0B1, FOXL2, FOXC1, SALL1

Molecular functions related to Developmental Disabilities according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA binding, bendingGO:0083019.8FOXL2, FOXC1
2double-stranded DNA bindingGO:0036909.7FOXL2, FOXC1
3RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.6FOXC1, FOXL2
4transcription factor bindingGO:0081349.2NR0B1, FOXL2, FOXC1
5sequence-specific DNA bindingGO:0435659.1NR0B1, FOXL2, FOXC1
6DNA bindingGO:0036778.2NR0B1, FOXL2, FOXC1, SALL1

Products for genes affiliated with Developmental Disabilities

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  • Antibodies
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Sources for Developmental Disabilities

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet