MCID: DVL002
MIFTS: 44

Developmental Disabilities malady

Summaries for Developmental Disabilities

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Developmental disabilities are severe, long-term problems. they may be physical, such as blindness. they may affect mental ability, such as learning disorders. or the problem can be both physical and mental, such as down syndrome. the problems are usually life-long, and can affect everyday living. there are many causes of developmental disabilities, including genetic or chromosome abnormalities. these cause conditions such as down syndrome and rett syndrome. prenatal exposure to substances. drinking alcohol when pregnant can cause fetal alcohol spectrum disorders. certain viral infections during pregnancy preterm birth often there is no cure, but treatment can help the symptoms. treatments include physical, speech, and occupational therapy. special education classes and psychological counseling can also help. nih: national institute of child health and human development

MalaCards: Developmental Disabilities is related to intellectual disability and microcephaly. An important gene associated with Developmental Disabilities is RMRP (RNA component of mitochondrial RNA processing endoribonuclease), and among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Wnt / Hedgehog / Notch. The compounds hpaii and ay 9944 dihydrochloride have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and bone, and related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Wikipedia:63 Developmental disability is a diverse group of severe chronic conditions that are due to mental and/or... more...

Aliases & Classifications for Developmental Disabilities

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63Wikipedia, 44Novoseek, 33MedlinePlus, 60UMLS
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Aliases & Descriptions:

developmental disabilities 63 44 33 60


Related Diseases for Developmental Disabilities

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17GeneCards, 18GeneDecks
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Diseases related to Developmental Disabilities via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1intellectual disability31.4FMR1, DCX, DHCR7, PAX6
2microcephaly30.1PAX6
3breast cancer30.1FOXC1, JAG1, PITX2, NR0B1, GLI1
4autistic disorder29.8FMR1
5autism spectrum disorder10.5
6cerebritis10.3
7cerebral palsy10.3
8learning disability10.2
9obesity10.2
10cervical cancer10.2
11cervicitis10.2
12coffin-siris syndrome10.1
13hepatitis d10.1
14hepatitis10.1
15mood disorder10.1
16substance abuse10.1
17iris hypoplasia and glaucoma10.0FOXC1
18peters plus syndrome10.0PAX6, FOXC1
19moebius syndrome10.0FOXL2
20syndactyly10.0DHCR7
21microphthalmia10.0PAX6, SALL1
22hypospadias10.0MID2
23glaucoma 3, primary congenital, d10.0PAX6, FOXC1
24coloboma10.0PAX6
25eye disease10.0PAX6, PITX2, FOXC1
26aniridia10.0FOXC1, PITX2, PAX6
27polydactyly10.0SALL1, OFD1, GLI1, DHCR7
28congenital heart defect10.0PITX2, JAG1, FOXC1, SALL1
29short stature10.0NR0B1, FGD1, RMRP, FMR1
30blindness10.0FOXC1
31axenfeld-rieger syndrome10.0PITX2, FOXC1
32ovarian disease10.0FMR1, FOXL2
33astrocytoma10.0PAX6
34mental retardation10.0FMR1, FOXC1, DCX, NR0B1, FGD1, DHCR7
35intrahepatic cholestasis10.0JAG1, SCT
36malignant glioma10.0SOX10, G6PC, PITX2, DCX, GLI1, PAX6
37metaphyseal dysplasia10.0RMRP, NR0B1
38premature ovarian failure10.0FOXL2, FMR1
39attention deficit hyperactivity disorder9.9
40speech and communication disorders9.9
41bone fracture9.9
42smith-lemli-opitz syndrome9.9
43neurofibromatosis9.9
44rett syndrome9.9
45bruxism9.9
46williams-beuren syndrome9.9
47angelman syndrome9.9
48costello syndrome9.9
49stereotypic movement disorder9.9
50creatine transporter deficiency9.9

Graphical network of the top 20 diseases related to Developmental Disabilities:



Diseases related to developmental disabilities

Clinical Features for Developmental Disabilities

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Drugs & Therapeutics for Developmental Disabilities

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Developmental Disabilities

Drug clinical trials:

Search ClinicalTrials for Developmental Disabilities

Search NIH Clinical Center for Developmental Disabilities

Search CenterWatch for Developmental Disabilities

Genetic Tests for Developmental Disabilities

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Anatomical Context for Developmental Disabilities

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32MalaCards
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MalaCards organs/tissues related to Developmental Disabilities:

32
Eye, Testes, Bone, Brain, Breast, Skin

Animal Models for Developmental Disabilities or affiliated genes

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36MGI
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Publications for Developmental Disabilities

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50PubMed
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Articles related to Developmental Disabilities:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
The effectiveness of aripiprazole in the management of problem behaviour in people with intellectual disabilities, developmental disabilities and/or autistic spectrum disorder - A systematic review. (24405794)
2014
2
The state of the science of employment and economic self-sufficiency for people with intellectual and developmental disabilities. (24303824)
2013
3
An evaluation of the EQUIP treatment programme with men who have intellectual or other developmental disabilities. (23281218)
2013
4
The role of community rehabilitation providers in employment for persons with intellectual and developmental disabilities: results of the 2010-2011 National Survey. (23909583)
2013
5
Photo-assisted recall increases estimates of energy and macronutrient intake in adults with intellectual and developmental disabilities. (24095784)
2013
6
Current perspective regarding adults with intellectual and developmental disabilities accessing computer technology. (23078291)
2013
7
Descriptive analysis of a staff injury-reduction intervention in a human services setting for children and youth with intellectual and developmental disabilities. (23682008)
2013
8
A systematic review of mindfulness intervention for individuals with developmental disabilities: long-term practice and long lasting effects. (22989576)
2013
9
Staff perspectives on the provision of end-of-life care in a community residence for older adults with developmental disabilities. (23659460)
2013
10
Healthcare transition in patients with rare genetic disorders with and without developmental disability: neurofibromatosis 1 and Williams-Beuren syndrome. (23696535)
2013
11
A wireless object location detector enabling people with developmental disabilities to control environmental stimulation through simple occupational activities with Nintendo Wii Balance Boards. (22502821)
2012
12
Psychometrics and utility of Psycho-Educational Profile-Revised as a developmental quotient measure among children with the dual disability of intellectual disability and autism. (22833108)
2012
13
Developmental disabilities and intracranial abnormalities in children with symptomatic cytomegalovirus and cochlear implants. (23762614)
2012
14
Maternal smoking during pregnancy and the prevalence of autism spectrum disorders, using data from the autism and developmental disabilities monitoring network. (22534110)
2012
15
Nutrition and food skills education for adults with developmental disabilities. (21382225)
2011
16
Do children with developmental disabilities and mental health conditions have greater difficulty using health services than children with physical disorders? (20364366)
2011
17
Midlife and aging parents of adults with intellectual and developmental disabilities: impacts of lifelong parenting. (22126660)
2011
18
Personal factors and perceived barriers to participation in leisure activities for young and adults with developmental disabilities. (21985988)
2011
19
Pediatric patients with cerebral palsy or other developmental disabilities. (22036482)
2011
20
Are adults with developmental disabilities more likely to visit EDs? (21316180)
2011
21
Long-term care of the aging population with intellectual and developmental disabilities. (21641512)
2011
22
De novo duplication 11p13 involving the PAX6 gene in a patient with neonatal seizures, hypotonia, microcephaly, developmental disability and minor ocular manifestations. (21271670)
2011
23
Mobile social network services for families with children with developmental disabilities. (21606040)
2011
24
Primary care of adults with developmental disabilities: Canadian consensus guidelines. (21571716)
2011
25
Twenty years of communication intervention research with individuals who have severe intellectual and developmental disabilities. (20687822)
2010
26
Sexual abuse prevention: a training program for developmental disabilities service providers. (20390782)
2010
27
Safety assessment of a home-based telecare system for adults with developmental disabilities in Indiana: a multi-stakeholder perspective. (20501628)
2010
28
Self-injury among a community cohort of young children at risk for intellectual and developmental disabilities. (20630541)
2010
29
Leadership development of individuals with developmental disabilities in the self-advocacy movement. (20731755)
2010
30
Early childhood predictors of mothers' and fathers' relationships with adolescents with developmental disabilities. (20367745)
2010
31
Case managers' and independent living counselors' perspectives on health promotion activities for individuals with physical and developmental disabilities. (21104516)
2010
32
Developmental disabilities across the lifespan. (20515667)
2010
33
Developmental disabilities: challenges for research practices and policies in the 21st century. (19563583)
2009
34
Menstrual suppression for adolescents with developmental disabilities. (19539199)
2009
35
The 10th anniversary of olmstead (1999): has it made a difference for people with developmental disabilities? (19842745)
2009
36
Using a Time Timer to increase appropriate waiting behavior in a child with developmental disabilities. (18926663)
2009
37
The nature and treatment of compulsions, obsessions, and rituals in people with developmental disabilities. (19013755)
2009
38
Parental caregivers of children with developmental disabilities mount a poor antibody response to pneumococcal vaccination. (18595654)
2009
39
Well-being of mid- and later-life mothers of children with developmental disabilities. (18581704)
2008
40
Diagnosis and treatment of mood disorders in adults with developmental disabilities. (18726158)
2008
41
The well-being of mothers of adolescents with developmental disabilities in relation to medical care utilization and satisfaction with health care. (17267176)
2008
42
The diagnosis and treatment of individuals with mental illness and developmental disabilities: an overview. (18766442)
2008
43
Introduction: survivors of childhood cancer: the new face of developmental disabilities. (18924153)
2008
44
Adults with developmental disabilities. Guidance for quality clinical care. (19998931)
2007
45
Factors that impact resuscitation preferences for young people with severe developmental disabilities. (17428144)
2007
46
Prevalence of autism spectrum disorders--autism and developmental disabilities monitoring network, six sites, United States, 2000. (17287714)
2007
47
Residential supports for persons with intellectual and developmental disabilities. (17563892)
2007
48
Developmental Disabilities (21290643)
2006
49
The natural history of hepatitis D virus infection in Illinois state facilities for the developmentally disabled. (11232702)
2001
50
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: a case example in developmental disabilities. (10638050)
1999

Genetic Variations for Developmental Disabilities

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Expression for genes affiliated with Developmental Disabilities

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Developmental Disabilities

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Pathways for genes affiliated with Developmental Disabilities

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51QIAGEN, 4Cell Signaling Technology
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Pathways related to Developmental Disabilities according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PAX6, FOXC1, SALL1
210.3GLI1, JAG1, FOXC1

Compounds for genes affiliated with Developmental Disabilities

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44Novoseek, 59Tocris Bioscience
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Compounds related to Developmental Disabilities according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hpaii4410.4NR0B1, FMR1
2ay 9944 dihydrochloride5910.2DHCR7, GLI1
3arginine449.7FMR1, SALL1, SCT, G6PC, PITX2, PAX6

GO Terms for genes affiliated with Developmental Disabilities

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16Gene Ontology
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Cellular components related to Developmental Disabilities according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polysomal ribosomeGO:04278810.1NR0B1, FMR1
2cytoplasmGO:0057379.7SALL1, FOXC1, PITX2, NR0B1, MID2, GLI1

Biological processes related to Developmental Disabilities according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1extraocular skeletal muscle developmentGO:00207410.6PITX2, FOXL2
2lacrimal gland developmentGO:03280810.6FOXC1, PAX6
3iris morphogenesisGO:06107210.6PAX6, PITX2
4neuronal stem cell maintenanceGO:09715010.5JAG1, SCT
5pituitary gland developmentGO:02198310.5PAX6, GLI1, NR0B1, SALL1
6regulation of cell migrationGO:03033410.5PAX6, PITX2, JAG1
7cell fate determinationGO:00170910.5PAX6, JAG1
8adrenal gland developmentGO:03032510.4NR0B1, SALL1
9positive regulation of transcription, DNA-dependentGO:04589310.4SALL1, FOXL2, FOXC1, GLI1, PAX6
10neuron migrationGO:00176410.3PITX2, DCX, PAX6
11negative regulation of transcription from RNA polymerase II promoterGO:00012210.3SALL1, FOXL2, FOXC1, PITX2, NR0B1
12digestive tract morphogenesisGO:04854610.3GLI1, SOX10
13central nervous system developmentGO:00741710.3PAX6, DCX, FMR1
14positive regulation of neuroblast proliferationGO:00205210.2SOX10, PAX6
15positive regulation of transcription from RNA polymerase II promoterGO:04594410.2SOX10, SALL1, FOXL2, FOXC1, JAG1, PITX2
16eye developmentGO:00165410.0PAX6, FOXC1

Molecular functions related to Developmental Disabilities according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:03149010.3PITX2, FOXC1
2RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.1SOX10, FOXL2, FOXC1, GLI1
3transcription factor bindingGO:00813410.1PAX6, NR0B1, PITX2, FOXC1, FOXL2, SOX10
4double-stranded DNA bindingGO:00369010.0PAX6, FOXC1, FOXL2

Products for genes affiliated with Developmental Disabilities

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Sources for Developmental Disabilities

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet