MCID: DXT001
MIFTS: 43

Dextrocardia malady

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Dextrocardia

Aliases & Descriptions for Dextrocardia:

Name: Dextrocardia 12 50 56 29 42 14
Heart Predominantly in Right Hemithorax 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9565
ICD10 33 Q24.0
MeSH 42 D003914
NCIt 47 C84669
SNOMED-CT 64 156925007 27637000
Orphanet 56 ORPHA1666
UMLS via Orphanet 70 C0011813 C0265863
ICD10 via Orphanet 34 Q24.0
MESH via Orphanet 43 D003914
UMLS 69 C0011813

Summaries for Dextrocardia

NIH Rare Diseases : 50 dextrocardia is a condition in which the heart is located in the right side of the chest instead of the left. it is usually present from birth (congenital). there are several types of dextrocardia.  the simplest type occurs when the shape and structure of the heart is a mirror image of a normal heart.  other types of dextrocardia may involve defects of the walls of the heart, nearby blood vessels, or other organs in the abdomen. chest x-raxys and echocardiograms can be used to determine which type of dextrocardia is present.  last updated: 1/14/2016

MalaCards based summary : Dextrocardia, also known as heart predominantly in right hemithorax, is related to dextrocardia with situs inversus and short stature wormian bones dextrocardia. An important gene associated with Dextrocardia is HES7 (Hes Family BHLH Transcription Factor 7), and among its related pathways/superpathways are Mesodermal Commitment Pathway and TGF-beta signaling pathway (KEGG). The drugs Spironolactone and diuretics have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and liver.

Wikipedia : 71 Dextrocardia (from Latin dexter, meaning \"right,\" and Greek kardia, meaning \"heart\") is a rare... more...

Related Diseases for Dextrocardia

Diseases related to Dextrocardia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
id Related Disease Score Top Affiliating Genes
1 dextrocardia with situs inversus 12.2
2 short stature wormian bones dextrocardia 12.0
3 dextrocardia with unusual facies and microphthalmia 11.8
4 kartagener syndrome 11.5
5 ciliary dyskinesia, primary, 1, with or without situs inversus 11.3
6 heterotaxy, visceral, 1, x-linked 11.3
7 levocardia 11.1
8 pagod syndrome 11.0
9 heterotaxy, visceral, 4, autosomal 10.8
10 heterotaxy, visceral, 5 10.8
11 stratton-parker syndrome 10.7
12 van allen myhre syndrome 10.7
13 situs inversus 10.6
14 myocardial infarction 10.2
15 transposition of the great arteries 10.1
16 poland syndrome 10.0
17 ventricular septal defect 10.0
18 acute myocardial infarction 10.0
19 malignant pineal area germ cell neoplasm 10.0 MYH7 NODAL
20 diaphragmatic hernia upper limb defects 10.0 CFAP53 HES7 NODAL
21 mosaic trisomy 1 10.0 MYH7 TNNT2
22 lymphoepithelioma-like thymic carcinoma 10.0 CFAP53 HES7 NODAL
23 retinitis pigmentosa 18 9.9 MYH7 TNNT2
24 heart disease 9.9
25 congenitally corrected transposition of the great arteries 9.9
26 atrial fibrillation 9.9
27 ostertagiasis 9.9 MYH7 TNNT2
28 primary cutaneous gamma/delta-positive t-cell lymphoma 9.9 MYH7 TNNT2
29 straddling and/or overriding mitral valve 9.9 ACVR2B CFAP53
30 bronchiectasis 9.9
31 tetralogy of fallot 9.9
32 pervasive developmental disorder 9.8 MYH7 TNNT2
33 pollen allergy 9.8 MT-ND1 MYH7 TNNT2
34 hirschsprung microcephaly cleft palate 9.8 ACVR2B CFAP53 NODAL
35 tricuspid atresia 9.8
36 sinusitis 9.8
37 artery disease 9.8
38 coronary artery disease 9.8
39 aneurysm 9.8
40 jmp syndrome 9.7 ACVR2B CFAP53 HES7 NODAL
41 lipoma 9.6
42 total anomalous pulmonary venous return 9.6
43 juxtaposition of the atrial appendages 9.6
44 lung agenesis 9.6
45 atrioventricular septal defect 9.6
46 right bundle branch block 9.6
47 rheumatic heart disease 9.6
48 inferior myocardial infarction 9.6
49 sick sinus syndrome 9.6
50 cardiomyopathy 9.6

Graphical network of the top 20 diseases related to Dextrocardia:



Diseases related to Dextrocardia

Symptoms & Phenotypes for Dextrocardia

Drugs & Therapeutics for Dextrocardia

Drugs for Dextrocardia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2 diuretics Phase 4
3 Natriuretic Agents Phase 4,Phase 3
4 Sodium Channel Blockers Phase 4
5 Hormone Antagonists Phase 4
6 Hormones Phase 4
7 Diuretics, Potassium Sparing Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9 Mineralocorticoid Receptor Antagonists Phase 4
10 Mineralocorticoids Phase 4
11
Nitroglycerin Approved, Investigational Phase 3 55-63-0 4510
12 Vasodilator Agents Phase 3
13 Natriuretic Peptide, Brain Phase 3
14 Pharmaceutical Solutions Phase 2
15
Nitric Oxide Approved 10102-43-9 145068
16
Carvedilol Approved, Investigational 72956-09-3 2585
17
Menthol Approved 2216-51-5 16666
18 Neurotransmitter Agents
19 Peripheral Nervous System Agents
20 Endothelium-Dependent Relaxing Factors
21 Anti-Asthmatic Agents
22 Protective Agents
23 Respiratory System Agents
24 Autonomic Agents
25 Bronchodilator Agents
26 Antioxidants
27 Adrenergic Agents
28 Adrenergic Antagonists
29 Adrenergic alpha-1 Receptor Antagonists
30 Adrenergic alpha-Antagonists
31 Adrenergic beta-Antagonists
32 Antihypertensive Agents
33 Liver Extracts

Interventional clinical trials:

(show all 33)
id Name Status NCT ID Phase
1 Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension Unknown status NCT01468571 Phase 4
2 Water Immersion in Right-Sided Heart Failure: A Pilot Study Completed NCT00654264 Phase 4
3 A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure. Completed NCT00270374 Phase 3
4 Ambrisentan in Single Ventricle Recruiting NCT02080637 Phase 2
5 Ketones in Heart Failure - Effects on Cardiac Efficiency Recruiting NCT03073356 Phase 2
6 Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia Recruiting NCT02871778 Phase 2
7 Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart Unknown status NCT01444222
8 Chest Physiotherapy and Lung Function in Primary Ciliary Dyskinesia Unknown status NCT01929356
9 Early Detection and Characterization of Primary Ciliary Dyskinesia Unknown status NCT01070914
10 Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide Unknown status NCT00739817
11 Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO) Unknown status NCT00686309
12 Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure Completed NCT00777725
13 PAHTCH (Carvedilol) Completed NCT01586156
14 Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients Completed NCT02658006
15 NIOX VERO Nasal Application in Primary Ciliary Dyskinesia Completed NCT02622061
16 Otolith Function in Patients With Primary Ciliary Dyskinesia Completed NCT01246258
17 Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia Completed NCT01155115
18 Diagnosis of Primary Ciliary Dyskinesia Completed NCT00783887
19 Dyskinesia, Heterotaxy and Congenital Heart Disease Completed NCT00608556
20 Genetic Study of Patients With Primary Ciliary Dyskinesia Completed NCT00005650
21 Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves Recruiting NCT02119442
22 Open Lung Strategy in Critically Ill Morbid Obese Patients Recruiting NCT02503241
23 Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery Recruiting NCT02831907
24 Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Recruiting NCT02432079
25 Global Congestive Heart Failure Registry Recruiting NCT03078166
26 International Prospective Patient Registry for Primary Ciliary Dyskinesia (PCD) Recruiting NCT02419365
27 Genetics of Primary Ciliary Dyskinesia Recruiting NCT02389049
28 Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease Recruiting NCT00807482
29 Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease Active, not recruiting NCT00722878
30 Evaluating Progression of and Diagnostic Tools for Primary Ciliary Dyskinesia in Children and Adolescents Active, not recruiting NCT00450918
31 Rare Genetic Disorders of the Breathing Airways Active, not recruiting NCT00323167
32 Registry Study on Primary Ciliary Dyskinesia in Chinese Children Not yet recruiting NCT02704455
33 In Vivo Measurements of Nasal Ciliary Beat Frequency by Using Interferometry Not yet recruiting NCT02699177

Search NIH Clinical Center for Dextrocardia

Cochrane evidence based reviews: dextrocardia

Genetic Tests for Dextrocardia

Genetic tests related to Dextrocardia:

id Genetic test Affiliating Genes
1 Dextrocardia 29

Anatomical Context for Dextrocardia

MalaCards organs/tissues related to Dextrocardia:

39
Heart, Lung, Liver, Spleen, Kidney, Testes, Testis

Publications for Dextrocardia

Articles related to Dextrocardia:

(show top 50) (show all 553)
id Title Authors Year
1
An unusual cause of 'dextrocardia'. ( 28087601 )
2017
2
ST-Elevation Myocardial Infarction in Situs Inversus Dextrocardia: A Case Report. ( 28042584 )
2016
3
Eventration of the diaphragm in a 4-year-old child diagnosed with dextrocardia. ( 27362414 )
2016
4
Percutaneous Left Main Coronary Artery Intervention in a Case of Dextrocardia. ( 27127445 )
2016
5
PERFORATED DUODENAL ULCER ASSOCIATED WITH SITUS INVERSUS AND DEXTROCARDIA. ( 27323596 )
2016
6
Robotic atrial septal defect closure and tricuspid annuloplasty in a case of situs inversus totalis with dextrocardia. ( 27344445 )
2016
7
cTGA with infundibular pulmonary stenosis with subaortic VSD with dextrocardia, situs solitus presenting with atypical atrioventricular nodal reentrant tachycardia. ( 27728044 )
2016
8
Mitral Valve Operation in Dextrocardia. ( 27106466 )
2016
9
Status asthmaticus with pseudo-dextrocardia, complicated by iatrogenic tension pneumothorax. ( 27583095 )
2016
10
HeartWare ventricular assist device as a bridge to heart transplantation in a patient with congenitally corrected transposition of the great arteries and dextrocardia. ( 27521176 )
2016
11
Transcatheter aortic valve replacement for severe aortic stenosis in dextrocardia with situs inversus: First reported case in the United States. ( 26889599 )
2016
12
Hemiretinal Artery Occlusion in an 11-Year-Old Child with Dextrocardia. ( 28050295 )
2016
13
Triple vessel percutaneous coronary intervention in a patient with situs inversus dextrocardia using a transradial approach. ( 27751321 )
2016
14
Creating a Fontan fenestration in a child with dextrocardia and interrupted inferior vena cava. ( 27212858 )
2016
15
Repair of Posterior Infarct Ventricular Septal Defect in a Patient with Dextrocardia and Situs Inversus. ( 26785697 )
2016
16
Myocardial Perfusion SPECT Imaging in Dextrocardia with Situs Inversus: A Case Report. ( 27408900 )
2016
17
Emergent percutaneous coronary intervention for acute myocardial infarction in patients with mirror dextrocardia: case reports and brief review. ( 27280091 )
2016
18
Successful Percutaneous Coronary Intervention for Chronic Total Occlusion of Left Anterior Descending Coronary Artery in a Patient with Dextrocardia. ( 28031659 )
2016
19
Valve sparing surgery in an adult patient with dextrocardia and annuloaortic ectasia. ( 27212978 )
2016
20
Fontan's circulation with dextrocardia, recent pulmonary embolism, and inferior vena cava filter: Anesthetic challenges for urgent hysterectomy. ( 26750698 )
2016
21
Dextrocardia with varied presentations. ( 27727982 )
2016
22
Successful cryoballoon pulmonary vein isolation in a patient with situs inversus and dextrocardia. ( 27920836 )
2016
23
Successful Obstetric Outcome in Dextrocardia with Situs Inversus and Moderate Pulmonary Hypertension- Rare Case. ( 27891408 )
2016
24
Implantable cardioverter-defibrillator in a patient with dextrocardia situs inversus. ( 27999649 )
2016
25
Working in the Mirror: Left Atrial Appendage Closure in a Patient With Dextrocardia. ( 27262859 )
2016
26
Criss-cross heart with dextrocardia and transposition of the great arteries: a rare pathology. ( 26875142 )
2016
27
Giant Heart of Classical Infantile-Onset Pompe Disease With Mirror Image Dextrocardia. ( 26286728 )
2015
28
Successful radiofrequency catheter ablation of atrioventricular nodal reentrant tachycardia in a patient with dextrocardia due to unilateral pulmonary agenesis: a case report. ( 25674017 )
2015
29
Perioperative implications and management of dextrocardia. ( 25957984 )
2015
30
Modified Senning Procedure for Correction of Atrioventricular Discordance With Total Anomalous Pulmonary Venous Return, Atrial Situs Inversus, Dextrocardia, and Bilateral Superior Venae Cavae. ( 26434442 )
2015
31
Unlilateral microtia, dextrocardia and situs inversus totalis: a possible new association. ( 25455296 )
2015
32
Left chest wall deformity, dextrocardia, and diaphragmatic hernia: a variant of Poland or new syndrome? ( 25968588 )
2015
33
Colon in the chest: an incidental dextrocardia: a case report study. ( 25674744 )
2015
34
An adult case of polysplenia syndrome associated with sinus node dysfunction, dextrocardia, and systemic venous anomalies. ( 25948350 )
2015
35
Long-term course of a patient with congenital corrected transposition of the great arteries and dextrocardia - The Fisher King. ( 26547729 )
2015
36
Dextrocardia and symmetric hypertrophic cardiomyopathy with multiple mutations of genes encoding the sarcomere proteins. ( 25863306 )
2015
37
Successful transradial percutaneous coronary intervention in a patient with dextrocardia and situs inversus. ( 25738020 )
2015
38
Ventricular tachycardia originating from the right ventricular outflow tract in a patient with dextrocardia. ( 26498717 )
2015
39
Dextrocardia in Adults with Congenital Heart Disease. ( 26541676 )
2015
40
Successful catheter ablation of idiopathic premature ventricular contractions originating from the "right" ventricular outflow tract in a patient with dextrocardia and situs inversus viscerum. ( 26151713 )
2015
41
Subpulmonary Obstruction from Aneurysmal Ventricular Septum in a Child with Dextrocardia and Congenitally Corrected Transposition of the Great Arteries. ( 26664321 )
2015
42
Determination of a new mutation in MT-ND1 gene of a patient with dextrocardia, ventriculoarterial discordance, and tricuspid atresia. ( 25626582 )
2015
43
Clinical diagnostic approach to congenital agenesis of right lung with dextrocardia: a case report with review of literature. ( 25689299 )
2015
44
Orthotropic heart transplantation for adult congenital heart disease: a case with heterotaxy and dextrocardia. ( 26162269 )
2015
45
The role of electrocardiogram in the diagnosis of dextrocardia with mirror image atrial arrangement and ventricular position in a young adult Nigerian in Ile-Ife: a case report. ( 26411880 )
2015
46
An Anteroseptal Accessory Pathway in a Patient with Dextrocardia and Situs Inversus. ( 25588496 )
2015
47
Off-pump coronary artery bypass grafting in patients with mirror-imaging dextrocardia. ( 26059016 )
2015
48
A twist of fate: situs inversus totalis with dextrocardia. ( 25681761 )
2015
49
CLINICAL CASE OF THE MONTH: A Review of Situs Inversus and Dextrocardia. ( 25978051 )
2015
50
A Temporal Correlation Between Electrocardiogram and Computed Tomography in Acquired Postpneumonectomy Dextrocardia. ( 26731881 )
2015

Variations for Dextrocardia

Expression for Dextrocardia

Search GEO for disease gene expression data for Dextrocardia.

Pathways for Dextrocardia

Pathways related to Dextrocardia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.28 ACVR2B HES7 NODAL
2 11.25 ACVR2B NODAL
3 11.15 MYH7 TNNT2
4 10.88 NODAL TNNT2
5
Show member pathways
10.65 ACVR2B NODAL

GO Terms for Dextrocardia

Cellular components related to Dextrocardia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sarcomere GO:0030017 8.96 MYH7 TNNT2
2 myofibril GO:0030016 8.62 MYH7 TNNT2

Biological processes related to Dextrocardia according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 9.51 MYH7 TNNT2
2 lung development GO:0030324 9.49 ACVR2B NODAL
3 anterior/posterior pattern specification GO:0009952 9.48 ACVR2B NODAL
4 BMP signaling pathway GO:0030509 9.46 ACVR2B NODAL
5 cardiac muscle contraction GO:0060048 9.43 MYH7 TNNT2
6 regulation of signal transduction GO:0009966 9.4 ACVR2B NODAL
7 muscle filament sliding GO:0030049 9.37 MYH7 TNNT2
8 mesoderm development GO:0007498 9.32 ACVR2B HES7
9 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.26 MYH7 TNNT2
10 gastrulation with mouth forming second GO:0001702 9.16 ACVR2B NODAL
11 positive regulation of activin receptor signaling pathway GO:0032927 8.96 ACVR2B NODAL
12 determination of left/right symmetry GO:0007368 8.8 ACVR2B CFAP53 NODAL

Sources for Dextrocardia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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