MCID: DXT001
MIFTS: 45

Dextrocardia malady

Cardiovascular, Fetal categories

Summaries for Dextrocardia

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Dextrocardia is a condition in which the heart is located in the right side of the chest instead of the left. it is usually present from birth (congenital). there are several types of dextrocardia.  the simplest type occurs when the shape and structure of the heart is a mirror image of a normal heart.  other types of dextrocardia may involve defects of the walls of the heart, nearby blood vessels, or other organs in the abdomen. last updated: 8/4/2011

MalaCards: Dextrocardia, also known as heart predominantly in right hemithorax, is related to situs inversus and ventricular septal defect. An important gene associated with Dextrocardia is ZIC3 (Zic family member 3), and among its related pathways are Axon guidance and Signaling by NODAL. Affiliated tissues include liver, kidney and lung, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Wikipedia:64 Dextrocardia is a congenital defect in which the heart is situated on the right side of the body. There... more...

Aliases & Classifications for Dextrocardia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 57SNOMED-CT, 40NCIt, 35MeSH, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Cardiovascular


Aliases & Descriptions:

dextrocardia 8 43 10 49
heart predominantly in right hemithorax 8


External Ids:

Disease Ontology8 DOID:9565
NCIt40 C84669
MeSH35 D003914
MESH via Orphanet36 D003914
SNOMED-CT57 27637000, 156925007
ICD10 via Orphanet26 Q24.0
SNOMED-CT via Orphanet58 27637000, 74034002
UMLS via Orphanet62 C0011813, C0265863

Related Diseases for Dextrocardia

Sources:
17GeneCards, 18GeneDecks
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Diseases in the dextrocardia with situs inversus family:

dextrocardia dextrocardia with unusual facies and microphthalmia

Diseases related to Dextrocardia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1situs inversus31.3ZIC3, MEGF8, DNAI1, DNAH11, DNAH5, INVS
2ventricular septal defect30.5TBX1, SLC35B2
3bronchiectasis30.3DNAI1
4kartagener syndrome30.2DNAI1, DNAH5
5poland syndrome10.4
6acute myocardial infarction10.4
7short stature wormian bones dextrocardia10.3
8dextrocardia with situs inversus10.2
9coronary artery disease,10.2
10atrioventricular septal defect10.2
11lung agenesis10.2
12image syndrome10.2
13sinusitis10.2
14pagod syndrome10.1
15dextrocardia with unusual facies and microphthalmia10.1
16tricuspid atresia10.1
17levocardia10.1
18marfan syndrome10.0
19wolff-parkinson-white syndrome10.0
20discrete subaortic stenosis10.0
21cleft palate10.0
22scimitar syndrome10.0
23diaphragmatic eventration10.0
24inferior myocardial infarction10.0
25sick sinus syndrome10.0
26thoraco abdominal enteric duplication10.0
27pulmonary function10.0
28rheumatic disease10.0
29carpenter syndrome10.0RAB23
30imperforate anus10.0TEF
31vacterl association10.0TEF
32congenital heart defect10.0TBX1, ZIC3
33asphyxiating thoracic dystrophy10.0INVS
34nephronophthisis 110.0INVS, NPHP4
35cystic kidney10.0INVS, NPHP4
36primary ciliary dyskinesia10.0RSPH9, DNAH5, DNAH11, DNAI1
37rhyns syndrome10.0NPHP4, DNAI1, DNAH5, INVS
38angina pectoris9.9
39johanson-blizzard syndrome9.9
40ebstein anomaly9.9
41congenital heart block9.9
42rheumatic fever9.9
43duodenal ulcer9.9
44mitral valve stenosis9.9
45lutembacher's syndrome9.9
46tracheal stenosis9.9
47mobius syndrome9.9
48ellis-van creveld syndrome9.9
49systemic lupus erythematosus9.9
50spondylocostal dysostosis9.9

Graphical network of the top 20 diseases related to Dextrocardia:



Diseases related to dextrocardia

Clinical Features for Dextrocardia

Drugs & Therapeutics for Dextrocardia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Dextrocardia

Drug clinical trials:

Search ClinicalTrials for Dextrocardia

Search NIH Clinical Center for Dextrocardia

Search CenterWatch for Dextrocardia

Genetic Tests for Dextrocardia

Anatomical Context for Dextrocardia

Sources:
33MalaCards
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MalaCards organs/tissues related to Dextrocardia:

33
Liver, Kidney, Lung, Spleen, Heart, Testis, Fetal liver, Fetal lung

Animal Models for Dextrocardia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Dextrocardia

Sources:
51PubMed
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Articles related to Dextrocardia:

(show top 50)    (show all 484)
idTitleAuthorsYear
1
Left-sided gallbladder discovered during laparoscopic cholecystectomy in a patient with dextrocardia. (23542707)
2012
2
Multimodality imaging of Poland syndrome with dextrocardia and limb anomalies. (22785521)
2012
3
Catheter ablation of persistent atrial fibrillation in a patient with dextrocardia. (22800910)
2012
4
Catheter ablation of atrial fibrillation in a patient with dextrocardia: what is the challenge? (21034570)
2010
5
A rare congenital finding in an elderly lady--scimitar syndrome with dextrocardia in a 79 year old. (20412495)
2010
6
Dextrocardia associated with left-sided Poland syndrome. (19169181)
2009
7
Staged approach for congenitally corrected transposition of the great arteries associated with dextrocardia and nonconfluent pulmonary artery. (19438783)
2009
8
Anatomically left-sided septal slow pathway ablation in dextrocardia and situs inversus totalis. (18556684)
2008
9
Successful catheter ablation of atrial fibrillation in a patient with dextrocardia. (18565975)
2008
10
Approach to dextrocardia in adults: review. (17515336)
2007
11
Prehospital thrombolysis of acute myocardial infarction in dextrocardia. (17901281)
2007
12
Coronary artery bypass grafting in a patient with situs inversus totalis and dextrocardia. (18157421)
2007
13
ECG of the month. Reversal of the arm leads or situs inversus with mirror-image dextrocardia? Reversal of the limb leads and of the precordial leads. (17539489)
2007
14
Transcatheter closure of a perimembranous ventricular septal defect in isolated dextrocardia. (17891519)
2007
15
Mechanical reperfusion during acute myocardial infarction in a patient with dextrocardia. (16446526)
2006
16
Radiofrequency catheter ablation of a coronary sinus-ventricular accessory connection in dextrocardia with complete situs inversus and an anomalous inferior vena cava. (15679649)
2005
17
Thallium-201 myocardial SPECT in a patient with mirror-image dextrocardia and left bundle branch block. (14575388)
2003
18
A case of dextrocardia, radial ray malformation and renal anomaly. (14564222)
2003
19
The versatility of the Amplatzer Septal Occluder for the management of multiple atrial septal defects in a patient with dextrocardia and situs inversus. (12042629)
2002
20
Balloon mitral valvotomy using Inoue technique in a patient of isolated dextrocardia with rheumatic mitral stenosis. (10624074)
1999
21
Covered and duplicate exstrophy with duplication of bladder, urethra, vagina and dextrocardia: a case report. (7747356)
1995
22
Warfarin embryopathy with dextrocardia and situs inversus. (8025399)
1994
23
Successful directional coronary atherectomy in a patient with dextrocardia and situs inversus. (8495472)
1993
24
Poland syndrome with dextrocardia. (1286890)
1992
25
The very low birthweight neonate with an interrupted aortic arch and dextrocardia. (1442034)
1992
26
Surgical repair of dextrocardia with tetralogy of Fallot--a case report. (3447965)
1987
27
Perforated duodenal ulcer with dextrocardia with situs inversus. (3746712)
1986
28
The Mustard procedure in transposition of the great arteries associated with juxtaposition of the atrial appendages with and without dextrocardia. (6827853)
1983
29
Electrocardiograms of the month. Regular sinus rhythm diagnosed as dextrocardia. (6952103)
1982
30
Myocardial infarction with dextrocardia and situs inversus. A rare case report. (7409849)
1980
31
Long-time observations on the Blalock-Taussig operation X. Dextrocardia. (886678)
1977
32
Unusual occurrence of dextrocardia with situs inversus in succeeding generations of a family. (839497)
1977
33
Dextrocardia, anteroseptal infarction, and fascicular block. (1080097)
1975
34
Letter: Dextrocardia associated with Poland's syndrome. (163109)
1975
35
Idiopathic hypertrophic subaortic stenosis in a patient with mirror-image dextrocardia. (1242008)
1975
36
Ventricular aneurysm, arrhythmia and open heart operation in a patient with dextrocardia. (4440953)
1974
37
Mirror-image dextrocardia with situs inversus and coarctation of the aorta. (4423031)
1974
38
Dextrocardia: angiocardiographic study and classificiation. (4757237)
1973
39
Systematization and clinical study of dextroversion, mirror-image dextrocardia, and laevoversion. (4635344)
1972
40
"Isolated atrial inversion". Visceral situs solitus, visceroatrial discordance, discordant ventricular d loop without transposition, dextrocardia: diagnosis and surgical correction. (5033730)
1972
41
Bronchial compression from enlarged, hypertensive right pulmonary artery with corrected transposition of great arteries, dextrocardia, and ventricular septal defect. Diagnosis and surgical treatment. (5451066)
1970
42
Pathologic anatomy of dextrocardia and its clinical implications. (5653057)
1968
43
Congenital dextrocardia with anterior wall myocardial infarction. (4952731)
1967
44
Isolated congenital dextrocardia. (14398627)
1955
45
Dextrocardia secondary to foreign body in left bronchus; report of two cases. (14892966)
1952
46
Cyanosis in an infant with dextrocardia, situs inversus, and tricuspid atresia. (15427245)
1950
47
Congenital dextrocardia with situs inversus complicated by hypertensive heart disease; reversal of hypertensive changes following thoracolumbar sympathectomy. (18119902)
1949
48
Dextrocardia in association with a short P-R interval with prolongation of the QRS complex. (21012951)
1946
49
CHEST LEADS IN CONGENITAL AND ACQUIRED DEXTROCARDIA. (18609895)
1942
50
ISOLATED DEXTROCARDIA. (20777353)
1933

Genetic Variations for Dextrocardia

Expression for genes affiliated with Dextrocardia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dextrocardia

Search GEO for disease gene expression data for Dextrocardia.

Pathways for genes affiliated with Dextrocardia

Sources:
54Reactome, 12EMD Millipore
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Pathways related to Dextrocardia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9ACVR2B, NODAL
2
Hide members
9.9ACVR2B, NODAL
3
Hide members
9.0DNAH5, DNAH11, DNAI1

Compounds for genes affiliated with Dextrocardia

GO Terms for genes affiliated with Dextrocardia

Sources:
16Gene Ontology
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Cellular components related to Dextrocardia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonemal dynein complexGO:0058589.3DNAH5, DNAH11
2ciliumGO:0059299.0INVS, DNAI1, NPHP4
3cilium axonemeGO:0350858.8RSPH9, DNAH5, DNAH11, DNAI1
4microtubuleGO:0058748.5DNAI1, DNAH11, DNAH5, INVS

Biological processes related to Dextrocardia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetryGO:190016410.3CITED2, NODAL
2determination of digestive tract left/right asymmetryGO:07190710.2ZIC3, MEGF8
3embryonic process involved in female pregnancyGO:06013610.2NODAL, CITED2
4positive regulation of activin receptor signaling pathwayGO:03292710.2NODAL, ACVR2B
5positive regulation of cell-cell adhesionGO:02240910.2NODAL, CITED2
6embryonic heart tube left/right pattern formationGO:06097110.1CITED2, INVS
7embryonic placenta developmentGO:00189210.1CITED2, NODAL
8embryonic cranial skeleton morphogenesisGO:04870110.0NODAL, TBX1
9heart loopingGO:00194710.0NODAL, CITED2, ZIC3
10thymus developmentGO:0485389.9TBX1, CITED2
11pancreas developmentGO:0310169.9ACVR2B, INVS
12anterior/posterior pattern specificationGO:0099529.9ZIC3, TBX1, ACVR2B
13mesoderm developmentGO:0074989.9ACVR2B, TBX1
14blood vessel remodelingGO:0019749.8TBX1, ACVR2B
15outflow tract morphogenesisGO:0031519.6TBX1, CITED2
16heart developmentGO:0075079.5CITED2, TBX1, ACVR2B, BCOR
17ciliary or bacterial-type flagellar motilityGO:0015399.5DNAH5, DNAH11
18positive regulation of transcription from RNA polymerase II promoterGO:0459449.1ZIC3, CITED2, TBX1, NODAL, TEF
19determination of left/right symmetryGO:0073689.0ACVR2B, DNAH11, TBX1, CITED2, ZIC3

Products for genes affiliated with Dextrocardia

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Sources for Dextrocardia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet