MCID: DXT001
MIFTS: 48

Dextrocardia malady

Cardiovascular diseases, Fetal diseases categories

Summaries for Dextrocardia

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Dextrocardia is a condition in which the heart is located in the right side of the chest instead of the left. it is usually present from birth (congenital). there are several types of dextrocardia.  the simplest type occurs when the shape and structure of the heart is a mirror image of a normal heart.  other types of dextrocardia may involve defects of the walls of the heart, nearby blood vessels, or other organs in the abdomen. last updated: 8/4/2011

MalaCards: Dextrocardia, also known as heart predominantly in right hemithorax, is related to situs inversus and ventricular septal defect. An important gene associated with Dextrocardia is ZIC3 (Zic family member 3), and among its related pathways are Axon guidance and Signaling by NODAL. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Wikipedia:63 Dextrocardia is a congenital defect in which the apex of the heart is situated on the right side of the... more...

Aliases & Classifications for Dextrocardia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 56SNOMED-CT, 39NCIt, 34MeSH, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

dextrocardia 8 42 10 48
heart predominantly in right hemithorax 8


External Ids:

Disease Ontology8 DOID:9565
NCIt39 C84669
MeSH34 D003914
MESH via Orphanet35 D003914
SNOMED-CT56 27637000, 156925007
ICD10 via Orphanet26 Q24.0
SNOMED-CT via Orphanet57 27637000, 74034002
UMLS via Orphanet61 C0011813, C0265863

Related Diseases for Dextrocardia

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17GeneCards, 18GeneDecks
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Diseases related to Dextrocardia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1situs inversus31.3INVS, DNAH5, DNAH11, DNAI1, MEGF8, ZIC3
2ventricular septal defect30.5SLC35B2, TBX1
3bronchiectasis30.3DNAI1
4congenital heart defect29.9TBX1, ZIC3
5kartagener syndrome29.7DNAH5, DNAI1
6myocardial infarction10.6
7poland syndrome10.4
8acute myocardial infarction10.4
9double outlet right ventricle10.3
10short stature wormian bones dextrocardia10.3
11tetralogy of fallot10.2
12hypertension10.2
13image syndrome10.2
14dextrocardia with situs inversus10.2
15coronary artery disease10.1
16atrioventricular septal defect10.1
17pagod syndrome10.1
18dextrocardia with unusual facies and microphthalmia10.1
19right bundle branch block10.0
20wolff-parkinson-white syndrome10.0
21discrete subaortic stenosis10.0
22cleft palate10.0
23scimitar syndrome10.0
24diaphragmatic eventration10.0
25inferior myocardial infarction10.0
26sick sinus syndrome10.0
27lipoma10.0
28mediastinitis10.0
29carpenter syndrome10.0RAB23
30vacterl association10.0TEF
31imperforate anus10.0TEF
32asphyxiating thoracic dystrophy10.0INVS
33nephronophthisis 110.0NPHP4, INVS
34cystic kidney10.0NPHP4, INVS
35primary ciliary dyskinesia10.0RSPH9, DNAH5, DNAH11, DNAI1
36rhyns syndrome10.0INVS, DNAH5, NPHP4, DNAI1
37angina pectoris9.8
38johanson-blizzard syndrome9.8
39ebstein anomaly9.8
40congenital heart block9.8
41rheumatic fever9.8
42duodenal ulcer9.8
43mitral valve stenosis9.8
44tracheal stenosis9.8
45mobius syndrome9.8
46ellis-van creveld syndrome9.8
47cerebritis9.8
48systemic lupus erythematosus9.8
49spondylocostal dysostosis9.8
50retinitis pigmentosa9.8

Graphical network of the top 20 diseases related to Dextrocardia:



Diseases related to dextrocardia

Clinical Features for Dextrocardia

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Drugs & Therapeutics for Dextrocardia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Dextrocardia

Genetic Tests for Dextrocardia

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Anatomical Context for Dextrocardia

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32MalaCards
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MalaCards organs/tissues related to Dextrocardia:

32
Heart, Liver, Lung, Spleen, Kidney, Testes, Bone, Testis

Animal Models for Dextrocardia or affiliated genes

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36MGI
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Publications for Dextrocardia

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50PubMed
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Articles related to Dextrocardia:

(show top 50)    (show all 483)
idTitleAuthorsYear
1
A dextrocardia in a foetal Egyptian mummy? (22814111)
2013
2
What is normal in an abnormality? Central venous cannulation in a patient with Situs inversus totalis with dextrocardia and polyCystic kidney disease. (24133338)
2013
3
Aortic arch replacement in an elderly patient with dextrocardia and situs inversus. (23103732)
2013
4
A rare association of pulmonary hypertension and dextrocardia with Poland syndrome. (24054492)
2013
5
Dextrocardia with situs inversus associated with non-compaction cardiomyopathy. (24030083)
2013
6
Dextrocardia, atrial septal defect, severe developmental delay, facial anomalies, and supernumerary ribs in a child with a complex unbalanced 8;22 translocation including partial 8p duplication. (22302699)
2012
7
Hyperacute anterior myocardial infarction in a patient with dextrocardia and situs inversus. (22710589)
2012
8
First case of trans apical implantation of an aortic valve in a patient with dextrocardia. (22413741)
2012
9
Roof-dependent atrial flutter after catheter ablation for persistent atrial fibrillation in dextrocardia with situs inversus. (20226271)
2011
10
Poland syndrome associated with ipsilateral lipoma and dextrocardia. (22115239)
2011
11
Off-Pump CABG in a Patient with Dextrocardia Totalis: a Case Report. (23074624)
2011
12
Dextrocardia in patients with Poland syndrome: phenotypic characterization provides insight into the pathogenesis. (19909992)
2010
13
Repeat right transradial intervention in 9 days in a patient with dextrocardia and situs inversus. (21224962)
2010
14
Successful catheter ablation of idiopathic premature ventricular contractions originating from the mid-lateral left ventricle in a patient with dextrocardia and situs solitus. (20550611)
2010
15
Primary angioplasty and later elective multivessel stenting in a patient with dextrocardia: a case report and literature review. (20603514)
2010
16
Aortopexy for tracheomalacia with dextrocardia, pulmonary artery sling, and congenital tracheal stenosis. (19766841)
2009
17
Atrial switch operation in a patient with dextrocardia, bilateral superior vena cavae, left atrial isomerism and unroofed coronary sinus. (19463645)
2009
18
Successful pacemaker implantation in a patient with dextrocardia situs inversus totalis. (19734550)
2009
19
ECG of the month: right-axis deviation of the QRS complex with precordial R-wave regression. Situs inversus with mirror-image dextrocardia, sinus rhythm, and a long P-R interval. (19772032)
2009
20
'Two-by-two' pulmonary vein isolation in the presence of a complete situs inversus and dextrocardia: use of magnetic navigation and 3D mapping with image integration. (19531541)
2009
21
Acute myocardial infarction due to right coronary artery occlusion in dextrocardia. (17869359)
2008
22
Off-pump coronary artery bypass surgery in dextrocardia: a report of two cases. (18577901)
2008
23
Situs inversus with dextrocardia with multiple cardiac lesions in adult. (18604030)
2007
24
Repeat right transradial percutaneous coronary intervention in a patient with dextrocardia: the right approach to the right-sided heart. (17191219)
2007
25
Dextrocardia in pregnancy: 20 years' experience. (16913549)
2006
26
Diagnosis and outcome of dextrocardia diagnosed in the fetus. (15219529)
2004
27
Double-outlet right ventricle associated with discordant atrioventricular connection and dextrocardia in a cat. (12934814)
2003
28
Partial trisomy 20q in a newborn with dextrocardia. (12558114)
2002
29
Radiofrequency catheter ablation of a right free-wall accessory pathway in dextrocardia with complete situs inversus. (11877926)
2002
30
Poland sequence with dextrocardia: which comes first? (9409872)
1997
31
Mitral valve replacement in a Jehovah's Witness with dextrocardia and situs solitus. (8953447)
1996
32
Scimitar syndrome with dextrocardia and right pulmonary vascular hypoplasia seen on pulmonary imaging. (8925622)
1996
33
Percutaneous balloon valvuloplasty in mirror-image dextrocardia and rheumatic mitral stenosis. (8221866)
1993
34
Thoraco-abdominal enteric duplication with meningocele, skeletal anomalies and dextrocardia. (2226553)
1990
35
Anesthetic management of labor in a patient with dextrocardia, congenitally corrected transposition, Wolff-Parkinson-White syndrome, and congestive heart failure. (2801815)
1989
36
Dextrocardia with and without situs viscerum inversus in two sibs. (3425603)
1987
37
Anesthesia for congenital esophageal atresia and tracheoesophageal fistula combine with dextrocardia--case report. (3695840)
1987
38
Noninvasive diagnosis of mirror-image dextrocardia with thoracic-abdominal discordance. (3966322)
1985
39
Total correction of double-outlet right ventricle, atrial septal defect, pulmonic stenosis with a concordant atrioventricular relationship, dextrocardia and situs inversus. (15227112)
1983
40
Acrocephalosyndactyly with hydrocephalus and dextrocardia in a Nigerian child. (7131579)
1982
41
Dextrocardia, small right hemithorax, and abnormal pulmonary vessel. (1157541)
1975
42
Dextrocardia with situs inversus and isolated levocardia in two male siblings. (4658677)
1972
43
Tetralogy of Fallot in dextrocardia. (5030886)
1972
44
Silent myocardial infarction in mirror-image dextrocardia. (5371988)
1969
45
Vectorcardiogram in dextrocardia, dextroversion and dextroposition. (4231741)
1968
46
Diagrammatic portrayal of variations in cardiac structure. Reference to transposition, dextrocardia and the concept of four normal hearts. (4873462)
1968
47
Cardiac infarction in dextrocardia. (5906165)
1966
48
Coarctation of aorta, dextrocardia with situs inversus totalis and Kartagener's syndrome. (5294436)
1965
49
Situs inversus with dextrocardia. (13902162)
1962
50
Simulated dextrocardia associated with bronchiectasis; report of case. (20280493)
1946

Genetic Variations for Dextrocardia

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Expression for genes affiliated with Dextrocardia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dextrocardia

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Pathways for genes affiliated with Dextrocardia

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53Reactome, 12EMD Millipore
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Pathways related to Dextrocardia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9ACVR2B, NODAL
2
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9.9ACVR2B, NODAL
3
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9.0DNAH5, DNAH11, DNAI1

Compounds for genes affiliated with Dextrocardia

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GO Terms for genes affiliated with Dextrocardia

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16Gene Ontology
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Cellular components related to Dextrocardia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonemal dynein complexGO:0058589.3DNAH11, DNAH5
2ciliumGO:0059299.0NPHP4, DNAI1, INVS
3cilium axonemeGO:0350858.8DNAI1, DNAH11, DNAH5, RSPH9
4microtubuleGO:0058748.5INVS, DNAH5, DNAH11, DNAI1

Biological processes related to Dextrocardia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetryGO:190016410.3CITED2, NODAL
2determination of digestive tract left/right asymmetryGO:07190710.2ZIC3, MEGF8
3embryonic process involved in female pregnancyGO:06013610.2NODAL, CITED2
4positive regulation of activin receptor signaling pathwayGO:03292710.2NODAL, ACVR2B
5positive regulation of cell-cell adhesionGO:02240910.2NODAL, CITED2
6embryonic heart tube left/right pattern formationGO:06097110.1CITED2, INVS
7embryonic placenta developmentGO:00189210.1CITED2, NODAL
8embryonic cranial skeleton morphogenesisGO:04870110.0NODAL, TBX1
9heart loopingGO:00194710.0NODAL, CITED2, ZIC3
10thymus developmentGO:0485389.9TBX1, CITED2
11pancreas developmentGO:0310169.9ACVR2B, INVS
12anterior/posterior pattern specificationGO:0099529.9ZIC3, TBX1, ACVR2B
13mesoderm developmentGO:0074989.9ACVR2B, TBX1
14blood vessel remodelingGO:0019749.8TBX1, ACVR2B
15outflow tract morphogenesisGO:0031519.6TBX1, CITED2
16heart developmentGO:0075079.5CITED2, TBX1, ACVR2B, BCOR
17ciliary or bacterial-type flagellar motilityGO:0015399.5DNAH5, DNAH11
18positive regulation of transcription from RNA polymerase II promoterGO:0459449.1ZIC3, CITED2, TBX1, NODAL, TEF
19determination of left/right symmetryGO:0073689.0ACVR2B, DNAH11, TBX1, CITED2, ZIC3

Products for genes affiliated with Dextrocardia

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Sources for Dextrocardia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet