MCID: DXT001
MIFTS: 48

Dextrocardia malady

Cardiovascular diseases, Fetal diseases categories

Summaries for Dextrocardia

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Dextrocardia is a condition in which the heart is located in the right side of the chest instead of the left. it is usually present from birth (congenital). there are several types of dextrocardia.  the simplest type occurs when the shape and structure of the heart is a mirror image of a normal heart.  other types of dextrocardia may involve defects of the walls of the heart, nearby blood vessels, or other organs in the abdomen. last updated: 8/4/2011

MalaCards: Dextrocardia, also known as heart predominantly in right hemithorax, is related to situs inversus and ventricular septal defect. An important gene associated with Dextrocardia is ZIC3 (Zic family member 3), and among its related pathways are Axon guidance and Signaling by NODAL. Affiliated tissues include heart, liver and lung, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Wikipedia:63 Dextrocardia is a congenital defect in which the apex of the heart is situated on the right side of the... more...

Aliases & Classifications for Dextrocardia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 56SNOMED-CT, 39NCIt, 34MeSH, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

dextrocardia 8 42 10 48
heart predominantly in right hemithorax 8


External Ids:

Disease Ontology8 DOID:9565
NCIt39 C84669
MeSH34 D003914
MESH via Orphanet35 D003914
SNOMED-CT56 27637000, 156925007
ICD10 via Orphanet26 Q24.0
SNOMED-CT via Orphanet57 27637000, 74034002
UMLS via Orphanet61 C0011813, C0265863

Related Diseases for Dextrocardia

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17GeneCards, 18GeneDecks
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Diseases related to Dextrocardia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1situs inversus31.3INVS, DNAH5, DNAH11, DNAI1, MEGF8, ZIC3
2ventricular septal defect30.5SLC35B2, TBX1
3bronchiectasis30.3DNAI1
4congenital heart defect29.9TBX1, ZIC3
5kartagener syndrome29.7DNAH5, DNAI1
6myocardial infarction10.6
7poland syndrome10.4
8acute myocardial infarction10.4
9double outlet right ventricle10.3
10short stature wormian bones dextrocardia10.3
11tetralogy of fallot10.2
12hypertension10.2
13image syndrome10.2
14dextrocardia with situs inversus10.2
15coronary artery disease10.1
16atrioventricular septal defect10.1
17pagod syndrome10.1
18dextrocardia with unusual facies and microphthalmia10.1
19right bundle branch block10.0
20wolff-parkinson-white syndrome10.0
21discrete subaortic stenosis10.0
22cleft palate10.0
23scimitar syndrome10.0
24diaphragmatic eventration10.0
25inferior myocardial infarction10.0
26sick sinus syndrome10.0
27lipoma10.0
28mediastinitis10.0
29carpenter syndrome10.0RAB23
30vacterl association10.0TEF
31imperforate anus10.0TEF
32asphyxiating thoracic dystrophy10.0INVS
33nephronophthisis 110.0NPHP4, INVS
34cystic kidney10.0NPHP4, INVS
35primary ciliary dyskinesia10.0RSPH9, DNAH5, DNAH11, DNAI1
36rhyns syndrome10.0INVS, DNAH5, NPHP4, DNAI1
37angina pectoris9.8
38johanson-blizzard syndrome9.8
39ebstein anomaly9.8
40congenital heart block9.8
41rheumatic fever9.8
42duodenal ulcer9.8
43mitral valve stenosis9.8
44tracheal stenosis9.8
45mobius syndrome9.8
46ellis-van creveld syndrome9.8
47cerebritis9.8
48systemic lupus erythematosus9.8
49spondylocostal dysostosis9.8
50retinitis pigmentosa9.8

Graphical network of the top 20 diseases related to Dextrocardia:



Diseases related to dextrocardia

Clinical Features for Dextrocardia

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Drugs & Therapeutics for Dextrocardia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Dextrocardia

Search CenterWatch for Dextrocardia

Genetic Tests for Dextrocardia

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Anatomical Context for Dextrocardia

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32MalaCards
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MalaCards organs/tissues related to Dextrocardia:

32
Heart, Liver, Lung, Spleen, Kidney, Bone, Testis, Testes

Animal Models for Dextrocardia or affiliated genes

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36MGI
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Publications for Dextrocardia

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50PubMed
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Articles related to Dextrocardia:

(show top 50)    (show all 483)
idTitleAuthorsYear
1
Slow pathway ablation using electro-anatomical mapping in a patient with corrected transposition of the great arteries, dextrocardia, and atrioventricular nodal reentrant tachycardia. (22764200)
2013
2
Giant pericardial cyst mimicking dextrocardia on chest X-ray. (23237843)
2013
3
Transhepatic approach to create stent fenestration in the extracardiac Fontan conduit in a child with dextrocardia and interrupted inferior vena cava with azygos continuation. (22777721)
2013
4
Symptomatic sick sinus syndrome requiring permanent pacemaker implantation in a patient uwith mirror image dextrocardia with situs inversus and infertility. (24000510)
2013
5
Left bundle branch block tachycardia in a case of dextrocardia: what is the mechanism? (24102917)
2013
6
Successful percutaneous coronary intervention for chronic total occlusion of right coronary artery in patient with dextrocardia. (23456428)
2013
7
Where are the leads? Pacemaker implantation in dextrocardia. (23194695)
2013
8
A technique for repair of atrioventricular canal defect in dextrocardia. (22328627)
2012
9
Primary percutaneous intervention: for acute myocardial infarction in a patient with dextrocardia and situs inversus. (22412251)
2012
10
Myocardial perfusion scintigraphy in a case of dextrocardia: Doing it "right". (24019657)
2012
11
Transradial rotablation in a patient with dextrocardia and acute ST-elevation myocardial infarction. (24265880)
2012
12
Combined spontaneous contralateral pneumothorax and post-pneumonectomy mediastinal shift-associated dextrocardia. (21243579)
2011
13
Coronary bypass grafting without use of cardiopulmonary bypass for dextrocardia. (21534456)
2011
14
Late right pulmonary artery stenosis after arterial switch operation in mirror image dextrocardia and situs inversus totalis. (22006611)
2011
15
Off-pump coronary artery bypass in poland syndrome with dextrocardia: case report. (21592399)
2011
16
Resynchronization therapy transvenous approach in dextrocardia and congenitally corrected transposition of great arteries. (20865682)
2010
17
Dextrocardia: practical clinical points and comments on terminology. (19727926)
2010
18
A case with de novo inv dup del(8p) associated with dextrocardia and corpus callosum agenesis. (20880309)
2010
19
Aortic translocation for the management of double-outlet right ventricle and pulmonary stenosis with dextrocardia: technique to avoid coronary insufficiency. (20103367)
2010
20
Coronary artery anatomy in complete transposition with situs solitus and dextrocardia. (20217063)
2010
21
Cardiac resynchronization therapy upgrade in a patient with dextrocardia and situs inversus. (19740907)
2009
22
Percutaneous drug-eluting stent implantation in a patient with dextrocardia and situs inversus. (17716754)
2008
23
Situs inversus with dextrocardia in the nuclear lab. (18256560)
2008
24
Acquired post-pneumonectomy dextrocardia. (17670169)
2004
25
Transcatheter closure of perimembranous ventricular septal defect in a patient with situs inversus and dextrocardia. (14560936)
2003
26
Dextrocardia: technical aspects of reoperative aortic and tricuspid valve replacement. (12220069)
2002
27
Myocardial infarction during sleep deprivation in a patient with dextrocardia--a case report. (11205938)
2001
28
Fetal diagnosis of atrioventricular septal defect with dextrocardia in trisomy 18. (11125933)
2000
29
Balloon Mitral and Aortic Valvuloplasty in Mirror-Image Dextrocardia. (10785698)
1996
30
Transesophageal echocardiography combined with magnetic resonance imaging for detecting venous anomalies in dextrocardia. A case report. (7785797)
1995
31
ECG in dextrocardia. (7978231)
1994
32
Dextrocardia, microphthalmia, cleft palate, choreoathetosis, and mental retardation in an infant born to consanguineous parents. (1609828)
1992
33
ECG of the month. VoilA ! Dextrocardia. (2002271)
1991
34
A case of dextrocardia with normal situs. (1801519)
1991
35
Systemic lupus erythematosus and dextrocardia. (2379347)
1990
36
Clinical anophthalmia, dextrocardia, and skeletal anomalies in an infant born to consanguineous parents. (2248283)
1990
37
On coronary angioplasty in a patient with dextrocardia. (2605636)
1989
38
Coronary bypass in dextrocardia. (6609052)
1984
39
Successful repair of double-outlet right ventricle, complete atrioventricular canal, and atrioventricular discordance associated with dextrocardia and pulmonary stenosis. (703376)
1978
40
Double primary cancers in 2 young sibs, leukemia in another, and dextrocardia in a fourth. (194673)
1977
41
Sick sinus syndrome requiring permanent pacemaker implantation in a patient with mirror-image dextrocardia. (1261330)
1976
42
Large diaphragmatic hernia simulating dextrocardia. (1055891)
1975
43
Isolated dextrocardia with right ventricular dominance. (4234070)
1968
44
New concepts in dextrocardia. Angiocardiographic considerations. (5944193)
1966
45
ANATOMIC TYPES OF CONGENITAL DEXTROCARDIA: DIAGNOSTIC AND EMBRYOLOGIC IMPLICATIONS. (14136294)
1964
46
RADIOISOTOPE SCANNING OF THE LIVER AND SPLEEN IN DEXTROCARDIA AND IN SITUS INVERSUS WITH LEVOCARDIA. (14119388)
1964
47
Dextrocardia, tetralogy of Fallot, and situs inversus; report of a case. (13028787)
1952
48
Multiple cardiac anomalies with dextrocardia and situs inversus. (15412944)
1950
49
Dextrocardia and bronchiectasis, a review of the literature and a report of two cases. (20996259)
1946
50
CONGENITAL HEART BLOCK WITH DEXTROCARDIA. (18609923)
1943

Genetic Variations for Dextrocardia

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Expression for genes affiliated with Dextrocardia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dextrocardia

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Pathways for genes affiliated with Dextrocardia

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53Reactome, 12EMD Millipore
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Pathways related to Dextrocardia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9ACVR2B, NODAL
2
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9.9ACVR2B, NODAL
3
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9.0DNAH5, DNAH11, DNAI1

Compounds for genes affiliated with Dextrocardia

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GO Terms for genes affiliated with Dextrocardia

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16Gene Ontology
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Cellular components related to Dextrocardia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonemal dynein complexGO:0058589.3DNAH5, DNAH11
2ciliumGO:0059299.0INVS, DNAI1, NPHP4
3cilium axonemeGO:0350858.8RSPH9, DNAH5, DNAH11, DNAI1
4microtubuleGO:0058748.5DNAI1, DNAH11, DNAH5, INVS

Biological processes related to Dextrocardia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetryGO:190016410.3CITED2, NODAL
2determination of digestive tract left/right asymmetryGO:07190710.2ZIC3, MEGF8
3embryonic process involved in female pregnancyGO:06013610.2NODAL, CITED2
4positive regulation of activin receptor signaling pathwayGO:03292710.2NODAL, ACVR2B
5positive regulation of cell-cell adhesionGO:02240910.2NODAL, CITED2
6embryonic heart tube left/right pattern formationGO:06097110.1CITED2, INVS
7embryonic placenta developmentGO:00189210.1CITED2, NODAL
8embryonic cranial skeleton morphogenesisGO:04870110.0NODAL, TBX1
9heart loopingGO:00194710.0NODAL, CITED2, ZIC3
10thymus developmentGO:0485389.9TBX1, CITED2
11pancreas developmentGO:0310169.9ACVR2B, INVS
12anterior/posterior pattern specificationGO:0099529.9ZIC3, TBX1, ACVR2B
13mesoderm developmentGO:0074989.9ACVR2B, TBX1
14blood vessel remodelingGO:0019749.8TBX1, ACVR2B
15outflow tract morphogenesisGO:0031519.6TBX1, CITED2
16heart developmentGO:0075079.5CITED2, TBX1, ACVR2B, BCOR
17ciliary or bacterial-type flagellar motilityGO:0015399.5DNAH5, DNAH11
18positive regulation of transcription from RNA polymerase II promoterGO:0459449.1ZIC3, CITED2, TBX1, NODAL, TEF
19determination of left/right symmetryGO:0073689.0ACVR2B, DNAH11, TBX1, CITED2, ZIC3

Products for genes affiliated with Dextrocardia

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Sources for Dextrocardia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet