MCID: DXT001
MIFTS: 43

Dextrocardia

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Dextrocardia

MalaCards integrated aliases for Dextrocardia:

Name: Dextrocardia 12 50 56 29 42 14
Heart Predominantly in Right Hemithorax 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9565
ICD10 33 Q24.0
MeSH 42 D003914
NCIt 47 C84669
SNOMED-CT 64 156925007 27637000
Orphanet 56 ORPHA1666
MESH via Orphanet 43 D003914
UMLS via Orphanet 70 C0011813 C0265863
ICD10 via Orphanet 34 Q24.0
UMLS 69 C0011813

Summaries for Dextrocardia

NIH Rare Diseases : 50 dextrocardia is a condition in which the heart is located in the right side of the chest instead of the left. it is usually present from birth (congenital). there are several types of dextrocardia.  the simplest type occurs when the shape and structure of the heart is a mirror image of a normal heart.  other types of dextrocardia may involve defects of the walls of the heart, nearby blood vessels, or other organs in the abdomen. chest x-raxys and echocardiograms can be used to determine which type of dextrocardia is present.  last updated: 1/14/2016

MalaCards based summary : Dextrocardia, also known as heart predominantly in right hemithorax, is related to dextrocardia with situs inversus and short stature wormian bones dextrocardia. An important gene associated with Dextrocardia is NODAL (Nodal Growth Differentiation Factor), and among its related pathways/superpathways are Mesodermal Commitment Pathway and TGF-beta signaling pathway (KEGG). The drugs Spironolactone and diuretics have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and liver, and related phenotype is growth/size/body region.

Wikipedia : 72 Dextrocardia (from Latin dexter, meaning \"right,\" and Greek kardia, meaning \"heart\") is a rare... more...

Related Diseases for Dextrocardia

Diseases related to Dextrocardia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
id Related Disease Score Top Affiliating Genes
1 dextrocardia with situs inversus 12.2
2 short stature wormian bones dextrocardia 12.0
3 dextrocardia with unusual facies and microphthalmia 11.8
4 kartagener syndrome 11.5
5 ciliary dyskinesia, primary, 1, with or without situs inversus 11.3
6 heterotaxy, visceral, 1, x-linked 11.3
7 levocardia 11.1
8 pagod syndrome 11.0
9 heterotaxy, visceral, 4, autosomal 10.8
10 heterotaxy, visceral, 5 10.8
11 stratton-parker syndrome 10.7
12 van allen myhre syndrome 10.7
13 situs inversus 10.6
14 hing torack dowston syndrome 10.3 ACVR2B NODAL
15 dhdds-cdg 10.3 HES7 NODAL
16 myocardial infarction 10.2
17 subglottis squamous cell carcinoma 10.2 DNAI1 NODAL
18 transposition of the great arteries 10.1
19 poland syndrome 10.0
20 ventricular septal defect 10.0
21 acute myocardial infarction 10.0
22 malignant pineal area germ cell neoplasm 10.0 MYH7 NODAL
23 x-linked sideroblastic anemia with ataxia 10.0 ACVR2B DNAI1 NODAL
24 atrial fibrillation 10.0
25 heart disease 10.0
26 congenitally corrected transposition of the great arteries 9.9
27 tetralogy of fallot 9.9
28 bronchiectasis 9.9
29 keratoconus 9.8 DNAI1 NODAL
30 coronary artery disease 9.8
31 tricuspid atresia 9.8
32 sinusitis 9.8
33 artery disease 9.8
34 aneurysm 9.8
35 sick sinus syndrome 9.7
36 hemorrhagic disease due to alpha-1-antitrypsin pittsburgh mutation 9.7 ACTC1 MYH7
37 oesophagostomiasis 9.7 ACTC1 MYH7
38 wolff-parkinson-white syndrome 9.6
39 lung agenesis 9.6
40 pulmonary hypertension 9.6
41 atrioventricular septal defect 9.6
42 rheumatic heart disease 9.6
43 diaphragmatic eventration 9.6
44 esophageal atresia 9.6
45 esophagitis 9.6
46 right bundle branch block 9.6
47 pneumothorax 9.6
48 duodenal ulcer 9.6
49 inferior myocardial infarction 9.6
50 mediastinitis 9.6

Graphical network of the top 20 diseases related to Dextrocardia:



Diseases related to Dextrocardia

Symptoms & Phenotypes for Dextrocardia

MGI Mouse Phenotypes related to Dextrocardia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.1 ACTC1 ACVR2B CTC1 DNAI1 HES7 NODAL

Drugs & Therapeutics for Dextrocardia

Drugs for Dextrocardia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
2 diuretics Phase 4
3 Diuretics, Potassium Sparing Phase 4
4 Hormone Antagonists Phase 4
5 Hormones Phase 4
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
7 Mineralocorticoid Receptor Antagonists Phase 4
8 Mineralocorticoids Phase 4
9 Natriuretic Agents Phase 4,Phase 3
10 Sodium Channel Blockers Phase 4
11
Nitroglycerin Approved, Investigational Phase 3 55-63-0 4510
12 Vasodilator Agents Phase 3
13 Natriuretic Peptide, Brain Phase 3
14 Pharmaceutical Solutions Phase 2
15
Nitric Oxide Approved 10102-43-9 145068
16
Carvedilol Approved, Investigational 72956-09-3 2585
17
Menthol Approved 2216-51-5 16666
18 Anti-Asthmatic Agents
19 Antioxidants
20 Autonomic Agents
21 Bronchodilator Agents
22 Endothelium-Dependent Relaxing Factors
23 Neurotransmitter Agents
24 Peripheral Nervous System Agents
25 Protective Agents
26 Respiratory System Agents
27 Liver Extracts
28 Adrenergic Agents
29 Adrenergic alpha-1 Receptor Antagonists
30 Adrenergic alpha-Antagonists
31 Adrenergic Antagonists
32 Adrenergic beta-Antagonists
33 Antihypertensive Agents

Interventional clinical trials:

(show all 37)

id Name Status NCT ID Phase Drugs
1 Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension Unknown status NCT01468571 Phase 4 Spironolactone;Placebo
2 Water Immersion in Right-Sided Heart Failure: A Pilot Study Completed NCT00654264 Phase 4
3 A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure. Completed NCT00270374 Phase 3 nesiritide
4 Ambrisentan in Single Ventricle Recruiting NCT02080637 Phase 2 Ambrisentan
5 Ketones in Heart Failure - Effects on Cardiac Efficiency Recruiting NCT03073356 Phase 2
6 Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia Recruiting NCT02871778 Phase 2 VX-371;Hypertonic Saline;Placebo (0.17% saline);Ivacaftor
7 Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart Unknown status NCT01444222
8 Chest Physiotherapy and Lung Function in Primary Ciliary Dyskinesia Unknown status NCT01929356
9 Early Detection and Characterization of Primary Ciliary Dyskinesia Unknown status NCT01070914
10 Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide Unknown status NCT00739817
11 Comparison of On-line and Off-line Measurements of Exhaled Nitric Oxide (NO) Unknown status NCT00686309
12 Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure Completed NCT00777725
13 PAHTCH (Carvedilol) Completed NCT01586156 Carvedilol;Carvedilol placebo
14 Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients Completed NCT02658006
15 Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery Completed NCT02831907
16 NIOX VERO Nasal Application in Primary Ciliary Dyskinesia Completed NCT02622061
17 Otolith Function in Patients With Primary Ciliary Dyskinesia Completed NCT01246258
18 Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia Completed NCT01155115
19 Diagnosis of Primary Ciliary Dyskinesia Completed NCT00783887
20 Dyskinesia, Heterotaxy and Congenital Heart Disease Completed NCT00608556
21 Genetic Study of Patients With Primary Ciliary Dyskinesia Completed NCT00005650
22 Transcatheter Valve Implantation in Patients With Dysfunctional Left and Right Sided Heart Valves Recruiting NCT02119442
23 Molecular Genetics of Heterotaxy and Related Congenital Heart Defects Recruiting NCT02432079
24 Global Congestive Heart Failure Registry Recruiting NCT03078166
25 Multiple Breath Washout, a Clinimetric Dataset Recruiting NCT03320382
26 MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia Recruiting NCT03279965
27 Registry for Primary Ciliary Dyskinesia Recruiting NCT03271840
28 High Resolution Micro OCT Imaging Recruiting NCT03256773
29 International Prospective Patient Registry for Primary Ciliary Dyskinesia (PCD) Recruiting NCT02419365
30 Genetics of Primary Ciliary Dyskinesia Recruiting NCT02389049
31 Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease Recruiting NCT00807482
32 Open Lung Strategy in Critically Ill Morbid Obese Patients Active, not recruiting NCT02503241
33 Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease Active, not recruiting NCT00722878
34 Evaluating Progression of and Diagnostic Tools for Primary Ciliary Dyskinesia in Children and Adolescents Active, not recruiting NCT00450918
35 Rare Genetic Disorders of the Breathing Airways Active, not recruiting NCT00323167
36 Registry Study on Primary Ciliary Dyskinesia in Chinese Children Not yet recruiting NCT02704455
37 In Vivo Measurements of Nasal Ciliary Beat Frequency by Using Interferometry Not yet recruiting NCT02699177

Search NIH Clinical Center for Dextrocardia

Cochrane evidence based reviews: dextrocardia

Genetic Tests for Dextrocardia

Genetic tests related to Dextrocardia:

id Genetic test Affiliating Genes
1 Dextrocardia 29

Anatomical Context for Dextrocardia

MalaCards organs/tissues related to Dextrocardia:

39
Heart, Lung, Liver, Kidney, Brain, Spleen, Testes

Publications for Dextrocardia

Articles related to Dextrocardia:

(show top 50) (show all 568)
id Title Authors Year
1
Unexpected mirror-image dextrocardia in a patient with ST elevation myocardial infarction. ( 28891179 )
2017
2
Review of surgical and anesthetic management for esophageal atresia with tracheoesophageal fistula, unilateral pulmonary agenesis and dextrocardia. ( 28417152 )
2017
3
Prenatal Diagnosis of Dextrocardia with Complex Congenital Heart Disease Using Fetal Intelligent Navigation Echocardiography (FINE) and a Literature Review. ( 28641300 )
2017
4
Severe aortic stenosis in dextrocardia with situs invertus and anomalous single coronary ostium treated with transcatheter aortic valve replacement. ( 28578896 )
2017
5
Successful left transradial coronary angiography in an elderly patient with dextrocardia and severe aortic stenosis. ( 28529182 )
2017
6
Dextrocardia With Situs Inversus and Levo-Transposition of Great Vessels. ( 28641729 )
2017
7
Case 4/2017 - Double-Chambered Right Ventricle with Dextrocardia and Hypoxemia Due to Atrial Shunt in a 4-Year-Old Girl. ( 28699979 )
2017
8
An unusual combination of mirror-image dextrocardia with familial medulloblastoma : Is there a histogenetic relationship? ( 28844926 )
2017
9
An unusual cause of 'dextrocardia'. ( 28087601 )
2017
10
Goldenhar Syndrome with Dextrocardia and Right Pulmonary Hypoplasia: An Unusual Association. ( 28377826 )
2017
11
Aeroembolism in left atrium during catheter ablation of atrial fibrillation in a patient with dextrocardia: a case report and review of the literature. ( 28577360 )
2017
12
Implantation of VVI pacemaker in a patient with dextrocardia, persistent left superior vena cava, and sick sinus syndrome: A case report. ( 28151908 )
2017
13
Image Diagnosis: Multivessel Percutaneous Coronary Intervention in Dextrocardia: Success with Usual Techniques in a Case of Mirror-Image Heart. ( 28633731 )
2017
14
Radiofrequency Pulmonary Vein Isolation in a Patient with Dextrocardia With Situs Inversus Totalis. ( 28462889 )
2017
15
Valve sparing surgery in an adult patient with dextrocardia and annuloaortic ectasia. ( 27212978 )
2016
16
Successful cryoballoon pulmonary vein isolation in a patient with situs inversus and dextrocardia. ( 27920836 )
2016
17
Implantable cardioverter-defibrillator in a patient with dextrocardia situs inversus. ( 27999649 )
2016
18
Eventration of the diaphragm in a 4-year-old child diagnosed with dextrocardia. ( 27362414 )
2016
19
Percutaneous Left Main Coronary Artery Intervention in a Case of Dextrocardia. ( 27127445 )
2016
20
Transcatheter aortic valve replacement for severe aortic stenosis in dextrocardia with situs inversus: First reported case in the United States. ( 26889599 )
2016
21
Successful Obstetric Outcome in Dextrocardia with Situs Inversus and Moderate Pulmonary Hypertension- Rare Case. ( 27891408 )
2016
22
cTGA with infundibular pulmonary stenosis with subaortic VSD with dextrocardia, situs solitus presenting with atypical atrioventricular nodal reentrant tachycardia. ( 27728044 )
2016
23
Robotic atrial septal defect closure and tricuspid annuloplasty in a case of situs inversus totalis with dextrocardia. ( 27344445 )
2016
24
ST-Elevation Myocardial Infarction in Situs Inversus Dextrocardia: A Case Report. ( 28042584 )
2016
25
Aortic Valve Replacement in Dextrocardia and Anomalous Origin of the Coronary Artery. ( 28238249 )
2016
26
Criss-cross heart with dextrocardia and transposition of the great arteries: a rare pathology. ( 26875142 )
2016
27
Creating a Fontan fenestration in a child with dextrocardia and interrupted inferior vena cava. ( 27212858 )
2016
28
Mitral Valve Operation in Dextrocardia. ( 27106466 )
2016
29
Status asthmaticus with pseudo-dextrocardia, complicated by iatrogenic tension pneumothorax. ( 27583095 )
2016
30
Working in the Mirror: Left Atrial Appendage Closure in a Patient With Dextrocardia. ( 27262859 )
2016
31
Fontan's circulation with dextrocardia, recent pulmonary embolism, and inferior vena cava filter: Anesthetic challenges for urgent hysterectomy. ( 26750698 )
2016
32
Emergent percutaneous coronary intervention for acute myocardial infarction in patients with mirror dextrocardia: case reports and brief review. ( 27280091 )
2016
33
Dextrocardia with varied presentations. ( 27727982 )
2016
34
Repair of Posterior Infarct Ventricular Septal Defect in a Patient with Dextrocardia and Situs Inversus. ( 26785697 )
2016
35
Myocardial Perfusion SPECT Imaging in Dextrocardia with Situs Inversus: A Case Report. ( 27408900 )
2016
36
Triple vessel percutaneous coronary intervention in a patient with situs inversus dextrocardia using a transradial approach. ( 27751321 )
2016
37
Successful transradial coronary angioplasty in a patient with dextrocardia and acute myocardial infarction. ( 28190738 )
2016
38
Hemiretinal Artery Occlusion in an 11-Year-Old Child with Dextrocardia. ( 28050295 )
2016
39
HeartWare ventricular assist device as a bridge to heart transplantation in a patient with congenitally corrected transposition of the great arteries and dextrocardia. ( 27521176 )
2016
40
Successful Percutaneous Coronary Intervention for Chronic Total Occlusion of Left Anterior Descending Coronary Artery in a Patient with Dextrocardia. ( 28031659 )
2016
41
PERFORATED DUODENAL ULCER ASSOCIATED WITH SITUS INVERSUS AND DEXTROCARDIA. ( 27323596 )
2016
42
Long-term course of a patient with congenital corrected transposition of the great arteries and dextrocardia - The Fisher King. ( 26547729 )
2015
43
A twist of fate: situs inversus totalis with dextrocardia. ( 25681761 )
2015
44
Unlilateral microtia, dextrocardia and situs inversus totalis: a possible new association. ( 25455296 )
2015
45
Dextrocardia in Adults with Congenital Heart Disease. ( 26541676 )
2015
46
Left chest wall deformity, dextrocardia, and diaphragmatic hernia: a variant of Poland or new syndrome? ( 25968588 )
2015
47
Successful catheter ablation of idiopathic premature ventricular contractions originating from the "right" ventricular outflow tract in a patient with dextrocardia and situs inversus viscerum. ( 26151713 )
2015
48
Off-pump coronary artery bypass grafting in patients with mirror-imaging dextrocardia. ( 26059016 )
2015
49
CLINICAL CASE OF THE MONTH: A Review of Situs Inversus and Dextrocardia. ( 25978051 )
2015
50
Giant Heart of Classical Infantile-Onset Pompe Disease With Mirror Image Dextrocardia. ( 26286728 )
2015

Variations for Dextrocardia

Expression for Dextrocardia

Search GEO for disease gene expression data for Dextrocardia.

Pathways for Dextrocardia

Pathways related to Dextrocardia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.28 ACVR2B HES7 NODAL
2 11.25 ACVR2B NODAL
3 11.15 ACTC1 MYH7
4 10.88 ACTC1 NODAL
5
Show member pathways
10.65 ACVR2B NODAL

GO Terms for Dextrocardia

Cellular components related to Dextrocardia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sarcomere GO:0030017 8.62 ACTC1 MYH7

Biological processes related to Dextrocardia according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 9.49 ACVR2B NODAL
2 lung development GO:0030324 9.48 ACVR2B NODAL
3 BMP signaling pathway GO:0030509 9.46 ACVR2B NODAL
4 cardiac muscle contraction GO:0060048 9.43 ACTC1 MYH7
5 heart development GO:0007507 9.43 ACVR2B DNAI1 NODAL
6 regulation of signal transduction GO:0009966 9.4 ACVR2B NODAL
7 muscle filament sliding GO:0030049 9.37 ACTC1 MYH7
8 mesoderm development GO:0007498 9.32 ACVR2B HES7
9 gastrulation with mouth forming second GO:0001702 9.16 ACVR2B NODAL
10 positive regulation of activin receptor signaling pathway GO:0032927 8.96 ACVR2B NODAL
11 determination of left/right symmetry GO:0007368 8.8 ACVR2B DNAI1 NODAL

Sources for Dextrocardia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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