MCID: DFN042
MIFTS: 19

Dfna 3 Nonsyndromic Hearing Loss and Deafness malady

Ear diseases category

Summaries for Dfna 3 Nonsyndromic Hearing Loss and Deafness

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32MalaCards
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MalaCards: Dfna 3 Nonsyndromic Hearing Loss and Deafness is related to gjb6-related dfna 3 nonsyndromic hearing loss and deafness and gjb2-related dfna 3 nonsyndromic hearing loss and deafness. An important gene associated with Dfna 3 Nonsyndromic Hearing Loss and Deafness is GJB6 (gap junction protein, beta 6, 30kDa), and among its related pathways are Calcium Regulation in the Cardiac Cell and Membrane Trafficking. The compounds 10panx and scrambled 10panx have been mentioned in the context of this disorder. Related mouse phenotype hearing/vestibular/ear.

Aliases & Classifications for Dfna 3 Nonsyndromic Hearing Loss and Deafness

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20GeneTests, 22GTR
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

dfna 3 nonsyndromic hearing loss and deafness 20 22


Related Diseases for Dfna 3 Nonsyndromic Hearing Loss and Deafness

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Dfna 3 Nonsyndromic Hearing Loss and Deafness:



Diseases related to dfna 3 nonsyndromic hearing loss and deafness

Clinical Features for Dfna 3 Nonsyndromic Hearing Loss and Deafness

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Drugs & Therapeutics for Dfna 3 Nonsyndromic Hearing Loss and Deafness

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Dfna 3 Nonsyndromic Hearing Loss and Deafness

Search CenterWatch for Dfna 3 Nonsyndromic Hearing Loss and Deafness

Genetic Tests for Dfna 3 Nonsyndromic Hearing Loss and Deafness

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20GeneTests, 22GTR
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Genetic tests related to Dfna 3 Nonsyndromic Hearing Loss and Deafness:

id Genetic test Affiliating Genes
1 Dfna 3 Nonsyndromic Hearing Loss and Deafness20 22 GJB6

Anatomical Context for Dfna 3 Nonsyndromic Hearing Loss and Deafness

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Animal Models for Dfna 3 Nonsyndromic Hearing Loss and Deafness or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dfna 3 Nonsyndromic Hearing Loss and Deafness:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1GJB2, GJB6

Publications for Dfna 3 Nonsyndromic Hearing Loss and Deafness

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Genetic Variations for Dfna 3 Nonsyndromic Hearing Loss and Deafness

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Expression for genes affiliated with Dfna 3 Nonsyndromic Hearing Loss and Deafness

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dfna 3 Nonsyndromic Hearing Loss and Deafness

Search GEO for disease gene expression data for Dfna 3 Nonsyndromic Hearing Loss and Deafness.

Pathways for genes affiliated with Dfna 3 Nonsyndromic Hearing Loss and Deafness

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Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN
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Pathways related to Dfna 3 Nonsyndromic Hearing Loss and Deafness according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1GJB2, GJB6
29.1GJB2, GJB6
39.1GJB2, GJB6
4
Hide members
9.1GJB2, GJB6

Compounds for genes affiliated with Dfna 3 Nonsyndromic Hearing Loss and Deafness

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Sources:
59Tocris Bioscience, 28IUPHAR, 24HMDB, 44Novoseek, 2BitterDB, 11DrugBank
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Compounds related to Dfna 3 Nonsyndromic Hearing Loss and Deafness according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
110panx599.3GJB2, GJB6
2scrambled 10panx599.3GJB2, GJB6
3carbenoxolone disodium599.2GJB2, GJB6
4gap 27599.2GJB2, GJB6
5octanol28 2410.1GJB6, GJB2
6flufenamic acid44 28 2 1112.1GJB2, GJB6
7carbenoxolone28 44 1111.0GJB2, GJB6
8ca2+288.8GJB2, GJB6

GO Terms for genes affiliated with Dfna 3 Nonsyndromic Hearing Loss and Deafness

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16Gene Ontology
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Cellular components related to Dfna 3 Nonsyndromic Hearing Loss and Deafness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:0059229.1GJB2, GJB6

Biological processes related to Dfna 3 Nonsyndromic Hearing Loss and Deafness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perception of soundGO:0076059.1GJB2, GJB6

Products for genes affiliated with Dfna 3 Nonsyndromic Hearing Loss and Deafness

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dfna 3 Nonsyndromic Hearing Loss and Deafness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet