MCID: DFN063
MIFTS: 21

Dfnb 1 Nonsyndromic Hearing Loss and Deafness malady

Genetic diseases (common), Ear diseases categories

Summaries for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section
Sources:
34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Dfnb 1 Nonsyndromic Hearing Loss and Deafness is related to gjb6-related dfnb 1 nonsyndromic hearing loss and deafness and gjb2-related dfnb 1 nonsyndromic hearing loss and deafness. An important gene associated with Dfnb 1 Nonsyndromic Hearing Loss and Deafness is GJB6 (gap junction protein, beta 6, 30kDa), and among its related pathways are Myometrial Relaxation and Contraction Pathways and Clathrin derived vesicle budding. The compounds 10panx and scrambled 10panx have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and hearing/vestibular/ear.

Aliases & Classifications for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section
Sources:
21GeneTests
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Ear diseases


Aliases & Descriptions:

dfnb 1 nonsyndromic hearing loss and deafness 21


Related Diseases for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of diseases related to Dfnb 1 Nonsyndromic Hearing Loss and Deafness:



Diseases related to dfnb 1 nonsyndromic hearing loss and deafness

Symptoms for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section

Drugs & Therapeutics for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

Drug clinical trials:

Search ClinicalTrials for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

Search NIH Clinical Center for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

Search CenterWatch for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

Genetic Tests for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section
Sources:
21GeneTests
See all sources

Genetic tests related to Dfnb 1 Nonsyndromic Hearing Loss and Deafness:

id Genetic test Affiliating Genes
1 Dfnb 1 Nonsyndromic Hearing Loss and Deafness21 GJB6

Anatomical Context for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section

Animal Models for Dfnb 1 Nonsyndromic Hearing Loss and Deafness or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Dfnb 1 Nonsyndromic Hearing Loss and Deafness:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.1GJB2, GJB6
2MP:00053778.8GJB2, GJB6

Publications for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section

Variations for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section

Expression for genes affiliated with Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dfnb 1 Nonsyndromic Hearing Loss and Deafness

Search GEO for disease gene expression data for Dfnb 1 Nonsyndromic Hearing Loss and Deafness.

Pathways for genes affiliated with Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 31KEGG
See all sources

Compounds for genes affiliated with Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section
Sources:
62Tocris Bioscience, 30IUPHAR, 25HMDB, 46Novoseek, 3BitterDB, 12DrugBank
See all sources

Compounds related to Dfnb 1 Nonsyndromic Hearing Loss and Deafness according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
110panx629.3GJB2, GJB6
2scrambled 10panx629.3GJB2, GJB6
3carbenoxolone disodium629.2GJB2, GJB6
4gap 27629.2GJB2, GJB6
5octanol30 2510.1GJB6, GJB2
6flufenamic acid30 46 3 1212.1GJB2, GJB6
7carbenoxolone46 30 1211.0GJB2, GJB6
8ca2+308.8GJB2, GJB6

GO Terms for genes affiliated with Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Dfnb 1 Nonsyndromic Hearing Loss and Deafness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:0059229.1GJB2, GJB6

Biological processes related to Dfnb 1 Nonsyndromic Hearing Loss and Deafness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perception of soundGO:0076059.1GJB2, GJB6

Products for genes affiliated with Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dfnb 1 Nonsyndromic Hearing Loss and Deafness

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet