MCID: DBT019
MIFTS: 15

Diabetes and Hearing Loss malady

Categories: Genetic diseases, Ear diseases

Aliases & Classifications for Diabetes and Hearing Loss

Aliases & Descriptions for Diabetes and Hearing Loss:

Name: Diabetes and Hearing Loss 24
Diabetes-Deafness Syndrome, Maternally Transmitted 24

Classifications:



Summaries for Diabetes and Hearing Loss

MalaCards based summary : Diabetes and Hearing Loss, also known as diabetes-deafness syndrome, maternally transmitted, is related to diabetes and deafness, maternally inherited and microlissencephaly iii. An important gene associated with Diabetes and Hearing Loss is MT-TL1 (Mitochondrially Encoded TRNA Leucine 1 (UUA/G)), and among its related pathways/superpathways is tRNA Aminoacylation. The drugs Iron and Metformin have been mentioned in the context of this disorder.

Related Diseases for Diabetes and Hearing Loss

Graphical network of the top 20 diseases related to Diabetes and Hearing Loss:



Diseases related to Diabetes and Hearing Loss

Symptoms & Phenotypes for Diabetes and Hearing Loss

Drugs & Therapeutics for Diabetes and Hearing Loss

Drugs for Diabetes and Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 2, Phase 3 7439-89-6 23925
2
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
3
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
4
Acetylcysteine Approved, Investigational Phase 2, Phase 3 616-91-1 12035
5 Hormone Antagonists Phase 2, Phase 3
6 Hormones Phase 2, Phase 3
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
8 Hypoglycemic Agents Phase 2, Phase 3
9 Incretins Phase 2, Phase 3
10
protease inhibitors Phase 2, Phase 3
11 Chelating Agents Phase 2, Phase 3
12 N-monoacetylcystine Phase 2, Phase 3
13 Sitagliptin Phosphate Phase 2, Phase 3
14 HIV Protease Inhibitors Phase 2, Phase 3
15 Dipeptidyl-Peptidase IV Inhibitors Phase 2, Phase 3
16 Expectorants Phase 2, Phase 3
17 Anti-Infective Agents Phase 2, Phase 3
18 Protective Agents Phase 2, Phase 3
19 Antidotes Phase 2, Phase 3
20 Iron Chelating Agents Phase 2, Phase 3
21 Respiratory System Agents Phase 2, Phase 3
22 Antiviral Agents Phase 2, Phase 3
23 Antioxidants Phase 2, Phase 3
24
Bezafibrate Approved Phase 2 41859-67-0 39042
25
Dantrolene Approved Phase 1, Phase 2 7261-97-4 2952 6914273
26 Neuromuscular Agents Phase 1, Phase 2
27 Peripheral Nervous System Agents Phase 1, Phase 2
28 Hypolipidemic Agents Phase 2
29 Lipid Regulating Agents Phase 2
30 Antimetabolites Phase 2
31
Exenatide Approved, Investigational 141758-74-9 15991534
32 Glucagon-Like Peptide 1
33 insulin
34 Alpha 1-Antitrypsin
35 Insulin, Globin Zinc
36 Protein C Inhibitor
37 Liver Extracts
38 Bile Acids and Salts

Interventional clinical trials:

(show all 18)
id Name Status NCT ID Phase
1 Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy Not yet recruiting NCT02882477 Phase 2, Phase 3
2 A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome Recruiting NCT02829268 Phase 1, Phase 2
3 A Study of Bezafibrate in Mitochondrial Myopathy Recruiting NCT02398201 Phase 2
4 The KHENERGY Study Recruiting NCT02909400 Phase 2
5 Mitochondrial nt3243 A>G Mutation in Taiwan Unknown status NCT02114554
6 GLP Analogs for Diabetes in Wolfram Syndrome Patients Unknown status NCT01302327
7 Epidemiology of Hearing Loss in Diabetic and Non-Diabetic Veterans Completed NCT00018486
8 Turner Syndrome: Genotype and Phenotype Completed NCT00006334
9 Integrative Health Care Model for Climacteric Stage Women Completed NCT01272115
10 Transitional Life Events in Patients With Friedreich's Ataxia: Implications for Genetic Counseling Completed NCT00056186
11 Assessment of Age-related Hearing Loss in HIV-1 Patients Recruiting NCT02154971
12 Wolfram Syndrome International Registry and Clinical Study Recruiting NCT02841553
13 Tracking Neurodegeneration in Early Wolfram Syndrome Recruiting NCT02455414
14 Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC) Recruiting NCT00571272
15 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
16 Natural History Study of GATA2 Deficiency and Related Disorders Recruiting NCT01905826
17 Diabetes Prevention Among Post-partum Women With History of Gestational Diabetes Recruiting NCT02240420
18 North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) Recruiting NCT01694940

Search NIH Clinical Center for Diabetes and Hearing Loss

Genetic Tests for Diabetes and Hearing Loss

Genetic tests related to Diabetes and Hearing Loss:

id Genetic test Affiliating Genes
1 Diabetes and Hearing Loss 24 MT-TL1

Anatomical Context for Diabetes and Hearing Loss

Publications for Diabetes and Hearing Loss

Variations for Diabetes and Hearing Loss

ClinVar genetic disease variations for Diabetes and Hearing Loss:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 MT-TK m.8296A> G single nucleotide variant Pathogenic rs118192102 GRCh37 Chromosome MT, 8296: 8296
2 MT-TL1 m.3243A> G single nucleotide variant Pathogenic rs199474657 GRCh37 Chromosome MT, 3243: 3243
3 MT-TE m.14709T> C single nucleotide variant Pathogenic rs121434453 GRCh37 Chromosome MT, 14709: 14709
4 MT-TE NC_012920.1: m.14692A> G single nucleotide variant Pathogenic rs879192165 GRCh37 Chromosome MT, 14692: 14692

Expression for Diabetes and Hearing Loss

Search GEO for disease gene expression data for Diabetes and Hearing Loss.

Pathways for Diabetes and Hearing Loss

Pathways related to Diabetes and Hearing Loss according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.04 MT-TE MT-TK MT-TL1

GO Terms for Diabetes and Hearing Loss

Sources for Diabetes and Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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