MCID: DBT019
MIFTS: 17

Diabetes and Hearing Loss malady

Categories: Genetic diseases (common), Ear diseases

Aliases & Classifications for Diabetes and Hearing Loss

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Aliases & Descriptions for Diabetes and Hearing Loss:

Name: Diabetes and Hearing Loss 22
 
Diabetes-Deafness Syndrome, Maternally Transmitted 22

Classifications:



Summaries for Diabetes and Hearing Loss

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MalaCards based summary: Diabetes and Hearing Loss, also known as diabetes-deafness syndrome, maternally transmitted, is related to maternally inherited diabetes and deafness and mertk-related retinitis pigmentosa. An important gene associated with Diabetes and Hearing Loss is MT-TL1 (Mitochondrially Encoded TRNA Leucine 1 (UUA/G)), and among its related pathways is tRNA Aminoacylation. Affiliated tissues include liver.

Related Diseases for Diabetes and Hearing Loss

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Graphical network of diseases related to Diabetes and Hearing Loss:



Diseases related to diabetes and hearing loss

Symptoms for Diabetes and Hearing Loss

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Drugs & Therapeutics for Diabetes and Hearing Loss

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Drugs for Diabetes and Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
BezafibrateapprovedPhase 21241859-67-039042
Synonyms:
2-(4-{2-[(4-chlorobenzoyl)amino]ethyl}phenoxy)-2-methylpropanoic acid
2-(P-(2-(P-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid
2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid
2-[4-(2-[4-Chlorobenzamido]ethyl)- phenoxy]-2-methylpropanoic acid
2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid
2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]isobutyric Acid
2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid
41859-67-0
AB00052265
AB1004588
AC-6817
AC1L20XS
AC1Q5E4V
AKOS005107743
Azufibrat
Azupharma Brand of Bezafibrate
B3346
B7273_SIGMA
BF-759
BM 15.075
BM 15075
BM-15.075
BM-15075
BM15.075
BPBio1_000589
BRD-K46018455-001-06-0
BRN 4267656
BSPBio_000535
BSPBio_001314
BSPBio_003119
Bayer Brand of Bezafibrate
Befibrat
Befizal
Berlin Chemie Brand of Bezafibrate
Berlin-Chemie Brand of Bezafibrate
Betapharm Brand of Bezafibrate
Beza Lande
Beza Puren
Beza-Lande
Beza-Puren
BezaLande
BezaPuren
Bezabeta
Bezacur
Bezafibrat
Bezafibrat PB
Bezafibrate (JP15/USAN/INN)
Bezafibrate Azupharma Brand
Bezafibrate Bayer Brand
Bezafibrate Berlin-Chemie Brand
Bezafibrate Betapharm Brand
Bezafibrate Cryopharma Brand
Bezafibrate Elfar Brand
Bezafibrate Hennig Brand
Bezafibrate Hexal Brand
Bezafibrate Isis Brand
Bezafibrate Lakeside Brand
Bezafibrate Merckle Brand
Bezafibrate Roche Brand
Bezafibrate Synthelabo Brand
Bezafibrate TAD Brand
Bezafibrate Teva Brand
Bezafibrate [USAN:BAN:INN:JAN]
Bezafibrato
Bezafibrato [INN-Spanish]
Bezafibrato [Spanish]
Bezafibrato [inn-spanish]
Bezafibratum
Bezafibratum [INN-Latin]
Bezafibratum [inn-latin]
Bezafisal
Bezalip
Bezalip Retard
Bezamerck
Bezatol
Bezatol SR
Bezatol SR (TN)
Bezatol sr (tn)
Bio2_000034
Bio2_000514
Boehringer Mannheim Brand of Bezafibrate
C19H20ClNO4
CAS-41859-67-0
CCRIS 9085
CHEBI:47612
 
CHEMBL264374
CID39042
Cedur
Cryopharma Brand of Bezafibrate
D001629
D01366
DB01393
DB08380
Difaterol
DivK1c_000092
EINECS 255-567-9
Elfar Brand of Bezafibrate
Eulitop
HMS1361B16
HMS1569K17
HMS1791B16
HMS1921H16
HMS1989B16
HMS2089F04
HMS2092B12
HMS500E14
Hennig Brand of Bezafibrate
Hexal Brand of Bezafibrate
I06-1311
IDI1_000092
IDI1_033784
Isis Brand of Bezafibrate
KBio1_000092
KBio2_000034
KBio2_001923
KBio2_002602
KBio2_004491
KBio2_005170
KBio2_007059
KBio3_000067
KBio3_000068
KBio3_002619
KBioGR_000034
KBioGR_000669
KBioSS_000034
KBioSS_001923
LO 44
LS-124535
Lakeside Brand of Bezafibrate
Lipox
MLS000028533
MLS001148205
Merckle Brand of Bezafibrate
MolPort-001-738-424
NCGC00016850-01
NCGC00016850-02
NCGC00016850-11
NCGC00023317-03
NCGC00023317-04
NCGC00023317-05
NCGC00023317-06
NCGC00023317-07
NCGC00023317-08
NINDS_000092
PB, Bezafibrat
Prestwick0_000378
Prestwick1_000378
Prestwick2_000378
Prestwick3_000378
Prestwick_724
Reducterol
Regadrin B
Roche Brand of Bezafibrate
SMR000058298
SPBio_000824
SPBio_002456
SPECTRUM1502046
ST51014927
Sklerofibrat
Solibay
Spectrum2_000922
Spectrum3_001500
Spectrum4_000325
Spectrum5_001079
Spectrum5_001967
Spectrum_001443
Synthelabo Brand of Bezafibrate
TAD Brand of Bezafibrate
Teva Brand of Bezafibrate
a-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyric acid
bezafibrate
durabezur
2AntimetabolitesPhase 29454
3Hypolipidemic AgentsPhase 22228
4
Exenatideapproved, investigational269141758-74-915991534
Synonyms:
141732-76-5
141758-74-9
286014-72-0
335149-21-8
AC 2993
AC 2993 LAR
AC 2993A
AC-2993
AC002993
AC2993
AC2993a
Bydureon
Byetta
 
C074031
CHEBI:490990
CHEMBL414357
Ex4 peptide
Exenatide
Exenatide Synthetic
Exenatide synthetic
Exendin 4
Exendin 4 (Heloderma suspectum)
Exendin-4
Extendin-4
LY2148568
Synthetic exendin-4
UNII-9P1872D4OL
5Bile Acids and Salts86
6Protein C Inhibitor85
7Liver Extracts3572
8Alpha 1-Antitrypsin87
9insulin4278
10Insulin, Globin Zinc4278
11Hypoglycemic Agents4503
12Incretins1326
13Hormones, Hormone Substitutes, and Hormone Antagonists9988
14Hormone Antagonists10002
15Glucagon-Like Peptide 1620
16Hormones11748

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1A Study of Bezafibrate in Mitochondrial MyopathyRecruitingNCT02398201Phase 2
2Epidemiology of Hearing Loss in Diabetic and Non-Diabetic VeteransCompletedNCT00018486
3Turner Syndrome: Genotype and PhenotypeCompletedNCT00006334
4Integrative Health Care Model for Climacteric Stage WomenCompletedNCT01272115
5Transitional Life Events in Patients With Friedreich's Ataxia: Implications for Genetic CounselingCompletedNCT00056186
6Mitochondrial nt3243 A>G Mutation in TaiwanRecruitingNCT02114554
7Assessment of Age-related Hearing Loss in HIV-1 PatientsRecruitingNCT02154971
8Tracking Neurodegeneration in Early Wolfram SyndromeRecruitingNCT02455414
9Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC)RecruitingNCT00571272
10North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)RecruitingNCT01694940
11Natural History Study of GATA2 Deficiency and Related DisordersRecruitingNCT01905826
12Diabetes Prevention Among Post-partum Women With History of Gestational DiabetesRecruitingNCT02240420
13GLP Analogs for Diabetes in Wolfram Syndrome PatientsNot yet recruitingNCT01302327

Search NIH Clinical Center for Diabetes and Hearing Loss

Genetic Tests for Diabetes and Hearing Loss

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Genetic tests related to Diabetes and Hearing Loss:

id Genetic test Affiliating Genes
1 Diabetes and Hearing Loss22 MT-TL1

Anatomical Context for Diabetes and Hearing Loss

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MalaCards organs/tissues related to Diabetes and Hearing Loss:

33
Liver

Animal Models for Diabetes and Hearing Loss or affiliated genes

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Publications for Diabetes and Hearing Loss

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Variations for Diabetes and Hearing Loss

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Clinvar genetic disease variations for Diabetes and Hearing Loss:

5
id Gene Variation Type Significance SNP ID Assembly Location
1MT-TKm.8296A> Gsingle nucleotide variantPathogenicrs118192102GRCh37Chr MT, 8296: 8296
2MT-TL1m.3243A> Gsingle nucleotide variantPathogenicrs199474657GRCh37Chr MT, 3243: 3243
3MT-TEm.14709T> Csingle nucleotide variantPathogenicrs121434453GRCh37Chr MT, 14709: 14709

Expression for genes affiliated with Diabetes and Hearing Loss

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Search GEO for disease gene expression data for Diabetes and Hearing Loss.

Pathways for genes affiliated with Diabetes and Hearing Loss

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Pathways related to Diabetes and Hearing Loss according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.5MT-TE, MT-TK, MT-TL1

GO Terms for genes affiliated with Diabetes and Hearing Loss

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Sources for Diabetes and Hearing Loss

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet