MCID: DBT005
MIFTS: 57

Diabetes Insipidus malady

Endocrine diseases category

Summaries for Diabetes Insipidus

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Diabetes insipidus (di) causes frequent urination. you become extremely thirsty, so you drink. then you urinate. this cycle can keep you from sleeping or even make you wet the bed. your body produces lots of urine that is almost all water. di is different from diabetes mellitus (dm), which involves insulin problems and high blood sugar. the symptoms can be similar. however, di is related to how your kidneys handle fluids. it's much less common than dm. urine and blood tests can show which one you have. usually, di is caused by a problem with your pituitary gland or your kidneys. treatment depends on the cause of the problem. medicines can often help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diabetes Insipidus, also known as central diabetes insipidus, is related to nephrogenic diabetes insipidus and neurogenic diabetes insipidus. An important gene associated with Diabetes Insipidus is AVPR2 (arginine vasopressin receptor 2), and among its related pathways are Vasopressin-regulated water reabsorption and Vasopressin-like receptors. The compounds forskolin and hgcl2 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, kidney and testes, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Wikipedia:63 Diabetes insipidus (DI) is a condition characterized by excessive thirst and excretion of large amounts... more...

Aliases & Classifications for Diabetes Insipidus

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

diabetes insipidus 8 10 33
central diabetes insipidus 60


External Ids:

Disease Ontology8 DOID:9409
NCIt39 C43263
MeSH34 D003919
SNOMED-CT56 15771004, 190484000
ICD9CM27 253.5
ICD1025 E23.2

Related Diseases for Diabetes Insipidus

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Diabetes Insipidus family:

Acquired Central Diabetes Insipidus Congenital Central Diabetes Insipidus

Diseases related to Diabetes Insipidus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1nephrogenic diabetes insipidus32.0AVPR2, AQP2
2neurogenic diabetes insipidus31.2AVP, AVPR2, OXT, NPTX2, UBOX5, AQP2
3panhypopituitarism31.1AVP, PRL, POMC
4diabetes mellitus31.0CASR, WFS1, POMC
5hypopituitarism31.0POMC, AVP, PRL, AQP2
6pituitary apoplexy30.6PRL, POMC
7lung cancer30.5POMC
8hypothyroidism30.5POMC, OXT, AVP, CASR, PRL
9craniopharyngioma30.5POMC, PRL, AVP
10hyperparathyroidism30.4CASR
11empty sella syndrome30.4PRL, POMC
12amenorrhea30.3POMC, PRL
13hypercalcemia30.2CASR, AVPR2
14hydrocephalus30.2L1CAM, AQP1
15sheehan syndrome30.2POMC, PRL
16pituitary cancer30.2PRL, POMC
17l1 syndrome30.0L1CAM
18hypertension30.0AVP, POMC
19pancreatitis30.0CASR
20polyhydramnios30.0SLC12A1, OXT, AQP1
21nephrolithiasis30.0CASR
22anorexia nervosa30.0POMC, PRL, OXT
23cushing's syndrome30.0PRL, POMC
24neurohypophyseal diabetes insipidus11.0
25histiocytosis10.7
26optic atrophy10.6
27langerhans-cell histiocytosis10.6
28leukemia10.6
29wolfram syndrome10.6
30acute leukemia10.6
31hydronephrosis10.5
32renal tubular acidosis10.5
33cerebritis10.5
34neuronitis10.5
35gestational diabetes10.5
36myeloid leukemia10.5
37acute myeloid leukemia10.4
38gestational diabetes insipidus10.4
39fanconi syndrome10.4
40encephalitis10.4
41thyroiditis10.4
42meningitis10.4
43erdheim-chester disease10.3
44holoprosencephaly10.3
45sarcoidosis10.3
46dipsogenic diabetes insipidus10.3
47acquired central diabetes insipidus10.3
48hellp syndrome10.3
49wegener's granulomatosis10.3
50nephrocalcinosis10.3

Graphical network of the top 20 diseases related to Diabetes Insipidus:



Diseases related to diabetes insipidus

Clinical Features for Diabetes Insipidus

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Drugs & Therapeutics for Diabetes Insipidus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Diabetes Insipidus

Drug clinical trials:

Search ClinicalTrials for Diabetes Insipidus

Search NIH Clinical Center for Diabetes Insipidus

Search CenterWatch for Diabetes Insipidus

Genetic Tests for Diabetes Insipidus

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Anatomical Context for Diabetes Insipidus

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32MalaCards
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MalaCards organs/tissues related to Diabetes Insipidus:

32
Pituitary, Kidney, Testes, Brain, Myeloid, Thyroid, Lung, Liver, Bone, Hypothalamus, Pineal, B cells, T cells, Prostate, Breast, Heart, Placenta, Skin, Monocytes, Bone marrow, Eye

Animal Models for Diabetes Insipidus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetes Insipidus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2PRL, WFS1, POMC, OXT, AQP1, AQP12A
2MP:000536710.1CASR, POMC, OXT, CLCNKA, AVPR2, AVP
3MP:000538610.0AQP2, CASR, L1CAM, NPTX2, PRL, WFS1
4MP:00053769.8OXT, POMC, WFS1, PRL, CASR, CLCNKA
5MP:00107719.8CASR, L1CAM, PRL, WFS1, POMC, OXT

Publications for Diabetes Insipidus

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Sources:
50PubMed
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Articles related to Diabetes Insipidus:

(show top 50)    (show all 1099)
idTitleAuthorsYear
1
Pulmonary thrombosis associated with antidiuretic hormone replacement therapy due to secondary diabetes insipidus after traumatic brain injury: A case report. (23131855)
2013
2
Incidence, predictors and early post-operative course of diabetes insipidus in paediatric craniopharygioma: a comparison with adults. (23386174)
2013
3
Central diabetes insipidus after staged spinal surgery. (24436879)
2013
4
Nephrogenic diabetes insipidus secondary to syphilis infection. (23609837)
2013
5
Lithium-induced nephrogenic diabetes insipidus after gastric banding. (22658328)
2013
6
Adipsia increases risk of death in patients with central diabetes insipidus. (24212879)
2013
7
Genetics and diagnosis of central diabetes insipidus. (22520736)
2012
8
Lithium induced diabetes insipidus, trauma and the shrunken brain. (23066556)
2012
9
Treatment of neurogenic diabetes insipidus. (22071315)
2011
10
A novel AVPR2 missense mutation in a Chinese boy with severe inherited nephrogenic diabetes insipidus. (22145481)
2011
11
Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus. (21768374)
2011
12
Diabetes insipidus associated with hemophagocytic lymphohistiocytosis: first case report. (21742615)
2011
13
Central diabetes insipidus after transsphenoidal surgery in dogs with Cushing's disease. (20736519)
2011
14
New autosomal recessive mutations in aquaporin-2 causing nephrogenic diabetes insipidus through deficient targeting display normal expression in Xenopus oocytes. (20403973)
2010
15
Interstitial nephritis and nephrogenic diabetes insipidus in a patient treated with pemetrexed. (20722569)
2010
16
Central diabetes insipidus induced by tuberculosis in a rheumatoid arthritis patient. (20711095)
2010
17
Transient central diabetes insipidus followed by pituitary apoplexy treated in a conservative way. (18641885)
2008
18
Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus. (18216143)
2008
19
Apoptosis of supraoptic AVP neurons is involved in the development of central diabetes insipidus after hypophysectomy in rats. (18578860)
2008
20
Gene symbol: AVP. Disease: Diabetes Insipidus, neurohypophyseal. (20960625)
2008
21
Complications of diabetes insipidus: the significance headache. (17411003)
2007
22
Transient gestational diabetes insipidus diagnosed in successive pregnancies: review of pathophysiology, diagnosis, treatment, and management of delivery. (17308961)
2007
23
Back to basics: congenital nephrogenic diabetes insipidus. (17908859)
2007
24
Inappropriate secretion of ADH and central diabetes insipidus are related to antiphospholipid antibodies in SLE--case report and review of the literature. (16935893)
2006
25
Diabetes insipidus and adrenal insufficiency in a patient with metastatic breast cancer. (16990696)
2006
26
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. (16508710)
2005
27
Infantile infection and diabetes insipidus in children with optic nerve hypoplasia. (16170115)
2005
28
Nephrolithiasis complicating treatment of diabetes insipidus. (15924254)
2005
29
Idiopathic neurohypophysial diabetes insipidus: reversibility of structural and functional renal abnormalities after treatment. (16033721)
2004
30
Five cases with central diabetes insipidus and hypogonadism as first presentation of neurosarcoidosis. (10754478)
2000
31
Identification of a novel nonsense mutation and a missense substitution in the vasopressin-neurophysin II gene in two Spanish kindreds with familial neurohypophyseal diabetes insipidus. (9580132)
1998
32
Nephrogenic diabetes insipidus and tethered cord syndrome with a lipoma of the cauda equina. (9533561)
1998
33
New mutations in the AQP2 gene in nephrogenic diabetes insipidus resulting in functional but misrouted water channels. (9048343)
1997
34
Anhidrosis: an unusual presentation of diabetes insipidus. (9409374)
1997
35
Urinary content of aquaporin 1 and 2 in nephrogenic diabetes insipidus. (8793791)
1996
36
A novel mutation in the coding region for neurophysin-II is associated with autosomal dominant neurohypophyseal diabetes insipidus. (8706292)
1996
37
A case of AlstrAPm syndrome associated with diabetes insipidus. (8556827)
1995
38
Acquired nephrogenic diabetes insipidus secondary to distal renal tubular acidosis and nephrocalcinosis associated with SjAPgren's syndrome. (7868806)
1994
39
A de novo mutation in the coding sequence for neurophysin-II (Pro24-->Leu) is associated with onset and transmission of autosomal dominant neurohypophyseal diabetes insipidus. (8045958)
1994
40
Atrial natriuretic peptide secretion was not directly affected by arginine vasopressin in diabetes insipidus. (1838565)
1991
41
Nonobstructive urinary tract dilatation in nephrogenic diabetes insipidus. (2076930)
1990
42
Syndrome of optic nerve atrophy, diabetes mellitus and diabetes insipidus]. (2084933)
1990
43
Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus. (2241462)
1990
44
Diabetes insipidus as a complication of neonatal group B streptococcal meningitis. (2235149)
1990
45
Diabetes insipidus versus syndrome of inappropriate antidiuretic hormone. (2776609)
1989
46
Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus. (2719505)
1989
47
Comparative therapeutic benefit of indomethacin, hydrochlorothiazide, and acetyl-salicylic acid in a patient with nephrogenic diabetes insipidus. (6588700)
1984
48
Coexistence of distal renal tubular acidosis and nephrogenic diabetes insipidus in two patients: implications for the pathogenesis of distal renal tubular acidosis. (757504)
1978
49
Lithium-induced nephrogenic diabetes insipidus. (949067)
1976
50
Pituitary insufficiency associated with pregnancy, panhypopituitarism, and diabetes insipidus. (13866539)
1962

Genetic Variations for Diabetes Insipidus

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Expression for genes affiliated with Diabetes Insipidus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes Insipidus

Search GEO for disease gene expression data for Diabetes Insipidus.

Pathways for genes affiliated with Diabetes Insipidus

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29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Diabetes Insipidus

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Diabetes Insipidus according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1forskolin44 49 1112.9POMC
2hgcl24410.8AQP2, AQP1, MIP
3hg2+4410.8AQP1, MIP
4oxytocin28 59 11 2413.8OXT, AVPR2, LNPEP
5mercury4410.8MIP, AQP1, AQP2
6hg2+2810.8MIP, AQP6, AQP1, AQP2
7ipsapirone44 2811.8OXT, POMC, PRL
8hexarelin44 2811.7OXT, POMC, PRL
9ammonium4410.7AQP1, SLC12A1, MIP
10atosiban28 4411.7OXT, AVPR2
11d[leu4,lys8]-vp5910.7AVPR2, AVP
12(d(ch2)51,tyr(me)2,arg8)-vasopressin5910.7AVPR2, AVP
13flesinoxan4410.7PRL, POMC
14[arg8]-vasopressin5910.7AVPR2, AVP
15pge24410.7POMC, LNPEP, SLC12A1, AQP2
16gnrh4410.7MRGPRX1
17furosemide44 49 59 28 11 2415.7AQP2, SLC12A1, POMC
18urea44 11 2412.7MIP, SLC12A1, AQP1, AQP2
19sr 4905959 2811.7AVPR2, AVP
20desmopressin44 59 28 1113.7AQP2, POMC, OXT, AVPR2, AVP, LNPEP
21glycerol44 11 2412.7POMC, MIP, AQP6, AQP1, AQP2
22nacl4410.7CASR, MIP, CLCNKA, SLC12A1, AQP1, AQP2
23pcmbs4410.7AQP1, MIP
24naloxone44 49 28 1113.7OXT, POMC, PRL
25potassium44 11 2412.7CASR, MIP, CLCNKA, AVPR2, SLC12A1, AQP1
26vasopressin28 11 2412.7LNPEP, AVPR2
27chloride4410.6CASR, MIP, CLCNKA, AVPR2, AVP, SLC12A1
28creatinine4410.6CASR, POMC, OXT, AVP, AQP1, AQP2
29cysteine4410.6CASR, MIP, AVPR2, AVP, AQP1, AQP2
30sodium44 2411.6CASR, MIP, CLCNKA, AVPR2, AVP, SLC12A1
31acth4410.6CASR, PRL, POMC, OXT, AVPR2, AVP
32nitric oxide44 11 2412.6CASR, OXT, MIP, AVP, SLC12A1, AQP1
33alanine4410.6CASR, POMC, AVPR2, AVP, LNPEP, AQP1
34dexamethasone44 49 28 1113.6PRL, POMC, MIP, AVP, AQP1, AQP2
35amastatin4410.6LNPEP, OXT
36steroid4410.6PRL, POMC, OXT, AVP, AQP1, AQP2
37acth 1-244410.6POMC, PRL
38glutamate4410.6CASR, L1CAM, NPTX2, OXT, MIP, AVPR2
39opiate4410.6PRL, POMC, OXT
40glucose4410.6CASR, PRL, POMC, MIP, AVP, LNPEP
41estradiol benzoate4410.5OXT, PRL
42epinephrine44 11 2412.5PRL, POMC, OXT, AQP2
43arginine4410.5CASR, ARHGAP4, PRL, POMC, OXT, MIP
44melatonin44 59 28 11 2414.5PRL, OXT, AVP
45calcium44 49 11 2413.4OXT, WFS1, NPTX2, MRGPRX1, CASR, MIP
46progestin4410.4OXT, POMC, PRL
47mifepristone44 59 28 1113.3OXT, POMC, PRL
48progesterone44 59 28 11 2414.3PRL, POMC, OXT, LNPEP, AQP2
49corticosterone44 59 2412.2PRL, POMC, OXT
50asparagine4410.1AVPR2, LNPEP, AQP1

GO Terms for genes affiliated with Diabetes Insipidus

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16Gene Ontology
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Cellular components related to Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:03014110.2AVP, OXT, POMC, PRL
2plasma membraneGO:00588610.1L1CAM, MRGPRX1, MIP, CLCNKA, AVPR2, LNPEP
3integral to plasma membraneGO:0058879.9CASR, MIP, CLCNKA, AVPR2, LNPEP, AQP6

Biological processes related to Diabetes Insipidus according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.7AQP1, AQP2
2multicellular organismal water homeostasisGO:05089110.6AQP1, AVP
3cellular response to mercury ionGO:07128810.6AQP2, AQP1
4excretionGO:00758810.6CLCNKA, AVPR2, AQP6, AQP2
5maternal aggressive behaviorGO:00212510.6OXT, AVP
6hyperosmotic salinity responseGO:04253810.6OXT, AVP
7female pregnancyGO:00756510.6AQP2, LNPEP, OXT, PRL
8water transportGO:00683310.6AQP2, MIP, AVPR2, AVP, AQP6, AQP1
9negative regulation of urine volumeGO:03581110.5OXT, AVPR2
10glycerol transportGO:01579310.5AQP1, AQP2
11cellular response to copper ionGO:07128010.5AQP2, AQP1
12transmembrane transportGO:05508510.5MIP, CLCNKA, AVPR2, AVP, SLC12A1, AQP6
13positive regulation of systemic arterial blood pressureGO:00308410.4AVPR2, AVP
14grooming behaviorGO:00762510.4AVP, OXT
15maternal behaviorGO:04271110.3AVP, OXT
16cell volume homeostasisGO:00688410.1AQP2, AQP1

Molecular functions related to Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water transmembrane transporter activityGO:00537210.4AQP2, AQP1
2water channel activityGO:01525010.3AQP1, AQP6, MIP
3neurohypophyseal hormone activityGO:00518510.3AVP, OXT
4glycerol transmembrane transporter activityGO:01516810.1AQP2, AQP1

Products for genes affiliated with Diabetes Insipidus

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Sources for Diabetes Insipidus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet