Diabetes Insipidus malady

MedlinePlus: Diabetes insipidus (di) causes frequent urination. you become extremely thirsty, so you drink. then you urinate. this cycle can keep you from sleeping or even make you wet the bed. your body produces big volumes of urine that are almost all water. di is different from diabetes mellitus (dm), which involves insulin problems and high blood sugar. the symptoms can be similar; however, di is related to how your kidneys handle fluids. it's much less common than dm. urine and blood tests can show which one you have. usually, di is caused by a problem with your pituitary gland or your kidneys. treatment depends on the cause of the problem. medicines can often help.²³

MalaCards: Diabetes Insipidus, also known as diabetes insipidus (disorder), is related to nephrogenic diabetes insipidus and neurogenic diabetes insipidus. An important gene associated with Diabetes Insipidus is AVPR2 (arginine vasopressin receptor 2), and among its related pathways are Vasopressin-regulated water reabsorption and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The compounds methimazole and desmopressin have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and myeloid, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Wikipedia: Diabetes insipidus (DI) is a condition characterized by excessive thirst and excretion of large amounts...⁴⁴ more...

Aliases & Descriptions:

diabetes insipidus 6 7 17 8 23 diabetes insipidus (disorder) 6

central diabetes insipidus 43

Diseases related to diabetes insipidus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 594)

id	Related Disease	Score	Top Affiliating Genes
1	nephrogenic diabetes insipidus	40.1	AVPR2, AQP2
2	neurogenic diabetes insipidus	37.1	LNPEP, AVP, AVPR2, AQP2, GNRH1, OXT
3	wolfram syndrome	33.4	SCG5, CISD2, INS, WFS1
4	enuresis	31.4	REN, AVP, AVPR2, AQP2, NPPA
5	panhypopituitarism	30.9	S100B, AVP, IGF1, CALCA, PRL, POMC
6	germinoma	30.5	CGA, CGB, AVP, CYP21A2, PRL, AFP
7	gestational diabetes	30.3	INS, ACP1, OXT, GAD1
8	cushing's syndrome	30.0	SCG5, CRH, POMC
9	sheehan syndrome	29.3	LNPEP, INS, IGF1, CRH, PRL, POMC
10	pituitary tumor	28.9	SCG5, IGF1, GNRH1, GHRH, TRH, CRH
11	hypoadrenalism	28.6	INS, CALCA, PTHLH, CRH, TG, POMC
12	anovulation	28.2	CGA, INS, IGF1, GNRH1, TRH, CYP21A2
13	amenorrhea	27.6	CGA, INS, IGF1, GNRH1, CALCA, TRH
14	acute myelomonocytic leukemia	27.3	MPO, MECOM, CSF3
15	wilms tumor	27.3	REN, VWF, AVPR2, AQP2, IGF1, F8
16	hydrocephalus	27.2	L1CAM, AVPR2, MRGPRX1, INS, AQP1, AQP4
17	histiocytosis	27.1	S100B, CD1A, INS, IGF1, TRH, CRH
18	hypercalcemia	27.0	AVP, AVPR2, IGF1, CASR, CALCA, PTHLH
19	encephalitis	26.3	S100B, AVP, AQP4, TPO, CRP, ACP1
20	aldosteronism	25.6	REN, CLCNKB, CGA, AVP, AVPR1A, AVPR2
21	hyperthyroidism	22.2	REN, VWF, CGA, CGB, MPO, INS
22	diabetes mellitus	20.7	REN, VWF, LNPEP, CISD2, CGA, AVP
23	leukemia	18.9	REN, VWF, SCG5, CGA, CGB, MPO
24	neuronitis	18.6	REN, VWF, LNPEP, SCG5, UCN, S100B
25	endolymphatic hydrops	13.9	AVP, AVPR2, MIP, AQP2, AQP7
26	inappropriate adh syndrome	13.9	AVP, AVPR2, AQP2, POMC, NPPA
27	pituitary-dependent cushing's disease	13.8	CRH, PRL, POMC
28	obstructive hydrocephalus	13.8	L1CAM, IGF1, PRL
29	bartter syndrome type 4	13.8	BSND, CLCNKB, CLCNKA
30	nelson syndrome	13.8	CRH, PRL, POMC
31	lymphocytic hypophysitis	13.8	IGF1, PRL, POMC
32	menieres disease	13.7	MIP, AQP1, AQP2, AQP4, AQP6, AQP7
33	conn's syndrome	13.7	REN, POMC, NPPA
34	bartter syndrome type 3	13.7	REN, CLCNKB, SLC12A1
35	familial hyperaldosteronism	13.7	REN, AGTR1, POMC
36	type 3 von willebrand disease	13.7	VWF, F8, PLAT
37	prolactin producing pituitary tumor	13.7	TRH, PRL, POMC
38	gonadal disease	13.7	IGF1, GNRH1, CRH, POMC
39	dent disease	13.7	REN, CLCNKB, CLCNKA, SLC12A1
40	adrenocorticotropic hormone deficiency	13.7	GHRH, CRH, POMC
41	isolated acth deficiency	13.6	TRH, CRH, PRL, POMC
42	pituitary carcinoma	13.6	GHRH, CRH, PRL, POMC
43	myoma	13.6	GNRH1, CALCA, OXT, OXTR
44	acth deficiency	13.6	TRH, CRH, PRL, POMC
45	pseudohypoparathyroidism type ia	13.6	IGF1, TRH, PRL
46	pituitary gland disease	13.6	CGA, IGF1, PRL
47	melancholia	13.6	AVPR1B, TRH, CRH, PRL, POMC
48	bartter syndrome type 4b	13.6	CLCNKB, CLCNKA
49	central retinal vein occlusion	13.6	VWF, F8, PLAT
50	glucocorticoid resistance	13.6	REN, CRH, PRL, POMC

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to diabetes insipidus:

²²

MGI Mouse Phenotypes related to diabetes insipidus:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.0	SCG5, CISD2, AVPR1B, AQP1, AQP12A, AQP7
2	hematopoietic system phenotype	MP:0005397	8.9	SLC12A1, CSF3, TG, PTHLH, CASR, AQP1
3	hearing/vestibular/ear phenotype	MP:0005377	8.4	IGF1, CALCA, PLAT, TSHR, SOD1, AQP4
4	renal/urinary system phenotype	MP:0005367	8.4	CISD2, AVP, AVPR2, ARHGAP1, INS, AQP1
5	skeleton phenotype	MP:0005390	8.4	SLC12A1, PLAT, PTHLH, CALCA, CASR, GNRH1
6	reproductive system phenotype	MP:0005389	8.3	GHRH, TSHR, OXT, OXTR, PRL, SLC12A1
7	integument phenotype	MP:0010771	8.3	CRH, OXT, OXTR, PRL, CSF3, POMC
8	digestive/alimentary phenotype	MP:0005381	8.1	CASR, PTHLH, PLAT, OXT, GAD1, GNRH1
9	adipose tissue phenotype	MP:0005375	8.1	POMC, ACE, PTHLH, IGF1, GPBAR1, AQP7
10	immune system phenotype	MP:0005387	8.1	PTHLH, CRH, PLAT, ACP1, AGTR1, TSHR
11	mortality/aging	MP:0010768	6.9	PLAT, TPO, CASR, CANX, F8, ACE
12	behavior/neurological phenotype	MP:0005386	6.5	AVPR1B, INS, AQP1, AQP3, AQP4, CANX
13	nervous system phenotype	MP:0003631	6.1	GNRH1, CANX, GHRH, TRH, PTHLH, CRH
14	cardiovascular system phenotype	MP:0005385	5.5	CALCA, PTHLH, CRP, PLAT, ACE, AGTR1
15	growth/size phenotype	MP:0005378	5.0	PLAT, ACE, ACP1, AGTR1, TSHR, TG
16	homeostasis/metabolism phenotype	MP:0005376	2.3	REN, AQP2, AQP3, AQP4, AQP7, AQP8

Articles related to diabetes insipidus:

(show top 50)    (show all 257)

id	Title	Authors	Year	Affiliating Genes
1	Familial neurohypophyseal diabetes insipidus due to a novel mutation in the arginine vasopressin-neurophysin II gene. (21498630)	de Fost M.... Fliers E.	2011	AVP
2	Functional characterization of vasopressin type 2 rec eptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and n ephrogenic syndrome of inappropriate antidiuresis: implications for treatments. (20159941)	Rochdi M.D.... Bouvier M.	2010	AVPR2
3	Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus. (19297548)	Hayashi M.... Oiso Y.	2009	AVP, NPTX2
4	Diverse vasopressin V2 receptor functionality underly ing partial congenital nephrogenic diabetes insipidus. (19812297)	Faerch M.... Corydon T.J.	2009	AVPR2
5	Autosomal dominant neurohypophyseal diabetes insipidus in two families. Molecular analysis of the vasopressin-neurophysin II gene and functional studies of three missense mutations. (19129716)	Hedrich C.M.... Huebner A.	2009	AVP
6	Characterization of D150E and G196D aquaporin-2 mutat ions responsible for nephrogenic diabetes insipidus: importance of a mild pheno type. (19458121)	Guyon C.... Bichet D.G.	2009	AQP2
7	Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation. (18854434)	Yang B.... Verkman A.S.	2009	AQP2
8	Characterization of V71M mutation in the aquaporin-2 gene causing nephrogenic diabetes insipidus. (19147915)	Bougacha-Elleuch N.... Ayadi H.	2008	AQP2
9	Transient gestational diabetes insipidus diagnosed in successive pregnancies: review of pathophysiology, diagnosis, treatment, and m anagement of delivery. (17308961)	Kalelioglu I.... Has R.	2007	LNPEP
10	A case of nephrogenic diabetes insipidus with a novel missense mutation in the AVPR2 gene. (17216256)	Ashida A.... Tamai H.	2007	AVPR2
11	Nephrogenic diabetes insipidus. (16580609)	Bichet D.G.	2006	AVPR2, AQP2
12	Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus. (16159898)	Nielsen J.... Nielsen S.	2006	AQP2
13	Novel vasopressin type 2 (AVPR2) gene mutations in Brazilian nephrogenic diabetes insipidus patients. (17020465)	Boson W.L.... De Marco L.	2006	AVPR2
14	Diabetes insipidus in mice with a mutation in aquaporin-2. (16121255)	Lloyd D.J.... Gekakis N.	2005	AVPR2, AQP2
15	Nephrogenic diabetes insipidus caused by mutation of Tyr205: a key residue of V2 vasopressin receptor function. (15841479)	Sangkuhl K.... Schoneberg T.	2005	AVPR2
16	Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus. (11754100)	Demura M.... Mabuchi H.	2002	AVPR2, ARHGAP4
17	Identification of a novel mutation in the arginine vasopressin- neurophysin II gene in familial central diabetes insipidus. (12012274)	Bullmann C.... Muller-Wieland D.	2002	AVP
18	Two novel aquaporin-2 mutations responsible for congenital nephrogenic diabetes insipidus in Chinese families. (12050236)	Lin S.H.... Lin Y.-F.	2002	AQP2
19	The property of a novel V2 receptor mutant in a patient with nephrogenic diabetes insipidus. (11232028)	Inaba S.... Miyamori I.	2001	AVPR2
20	Familial neurohypophysial diabetes insipidus in a large Dutch kindred: effect of the onset of diabetes on growth in children and cell biological defects of the mutant vasopressin prohormone. (11443218)	Nijenhuis M.... Burbach J.P.H.	2001	AVP
21	Hypertrophic pachymeningitis with anti-neutrophil cytoplasmic antibody (p-ANCA), and diabetes insipidus. (11903097)	Takuma H.... Nishizawa Y.	2001	MPO
22	Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. (11035038)	Yang B.... Verkman A.S.	2001	AQP2
23	Central diabetes insipidus as the first manifestation of neurosarcoidosis in a 10-year-old girl. (11251374)	Konrad D.... Schoenle E.J.	2000	ACE
24	Molecular analyses of the vasopressin type 2 receptor and aquaporin-2 genes in Brazilian kindreds with nephrogenic diabetes insipidus. (10477431)	Rocha J.L.... De Marco L.	1999	AVPR2
25	A novel mutation (R97C) in the neurophysin moiety of prepro-vasopressin-neurophysin II associated with autosomal-dominant neurohypop hyseal diabetes insipidus. (10329029)	Rutishauser J.... Robertson G.L.	1999	AVP
26	C112R, W323S, N317K mutations in the vasopressin V2 receptor gene in patients with nephrogenic diabetes insipidus. (10694923)	Szalai C.... Czinner A.	1998	AVPR2
27	Molecular biological studies on patients with nephrogenic diabetes insipidus (9579101)	Szalai C.... Czinner A.	1998	AVPR2
28	Heterogeneity in clinical manifestation of autosomal dominant neurohypophyseal diabetes insipidus caused by a mutation encoding Ala-1-->Val in the signal peptide of the arginine vasopressin/neurophysin II/copeptin precursor. (8989232)	Repaske D.R.... Phillips J.A.	1997	AVP
29	Primary intrasellar mixed germ-cell tumor with precocious puberty and diabetes insipidus. (9083701)	Cho D.Y.... Ho W.L.	1997	CGA, AFP, CGB
30	Manifestation of subclinical diabetes insipidus due to pituitary tumor during pregnancy. (8980900)	Hashimoto M.... Kudo N.	1996	LNPEP
31	Urinary content of aquaporin 1 and 2 in nephrogenic diabetes insipidus. (8793791)	Deen P.M.... Van Os C.H.	1996	AVPR2, AQP1, AQP2
32	Recurrent mutations in the vasopressin-neurophysin II gene cause autosomal dominant neurohypophyseal diabetes insipidus. (8964872)	Repaske D.R.... Phillips J.A.	1996	AVP
33	Vasopressin V2 receptor mutants that cause X-linked nephrogenic diabetes insipidus: analysis of expression, processing, and function. (8863826)	Oksche A.... Rosenthal W.	1996	AVPR2
34	A new type of familial central diabetes insipidus caused by a single base substitution in the neurophysin II coding region of the vasopressin gene. (8626836)	Ueta Y.... Shigemasa C.	1996	AVP
35	Binding-, intracellular transport-, and biosynthesis-defective mutants of vasopressin type 2 receptor in patients with X-linked nephrogenic diabetes insipidus. (7560098)	Tsukaguchi H.... Inada M.	1995	AVPR2
36	Congenital nephrogenic diabetes insipidus (7939338)	Thibonnier M.	1994	AVPR2
37	Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus. (7987330)	Wenkert D.... Spiegel A.M.	1994	AVPR2
38	Detection of vasopressin cell antibodies in some patients with autoimmune endocrine diseases without overt diabetes insipidus. (8137514)	De Bellis A.... Bellastella A.	1994	INS
39	Novel mutations in the V2 vasopressin receptor gene in two pedigrees with congenital nephrogenic diabetes insipidus. (8045948)	Yuasa H.... Saito H.	1994	AVPR2
40	Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus. (8037205)	Bichet D.G.... Morgan K.	1994	AVPR2
41	Possible involvement of inefficient cleavage of preprovasopressin by signal peptidase as a cause for familial central diabetes insipidus. (8514868)	Ito M.... Lively M.O.	1993	AVP
42	A Null mutation in the vasopressin V2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus in the Hopewell kindred. (8401502)	Holtzman E.J.... Ausiello D.A.	1993	AVPR2
43	A molecular defect in the vasopressin V2-receptor gene causing nephrogenic diabetes insipidus. (8479490)	Holtzman E.J.... Ausiello D.A.	1993	AVPR2
44	Anterior pituitary function and computed tomography/magnetic resonance imaging in patients with Langerhans cell histiocytosis and diabetes insipidus. (8412998)	Broadbent V.... Kendall B.	1993	INS
45	Mutations in the vasopressin type 2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus. (1303271)	van den Ouweland A.M.W.... van Oost B.A.	1992	AVPR2
46	A missense mutation in the vasopressin-neurophysin precursor gene cosegregates with human autosomal dominant neurohypophyseal diabetes insipidus. (1740104)	Bahnsen U.... Schmale H.	1992	AVP
47	Mutations in the V2 vasopressin receptor gene are associated with X- linked nephrogenic diabetes insipidus. (1303257)	Pan Y.... Gitschier J.	1992	AVPR2
48	Atrial natriuretic peptide secretion was not directly affected by arginine vasopressin in diabetes insipidus. (1838565)	Shimizu H.... Shimomura Y.	1991	NPPA
49	Syndrome of optic nerve atrophy, diabetes mellitus a nd diabetes insipidus (2084933)	KolomoA-skaia M.B.	1990	INS
50	Derivatives of somatic cell hybrids which carry the h uman gene locus for nephrogenic diabetes insipidus (NDI) express functional vas opressin renal V2-type receptors. (2168411)	Jans D.A.... Fahrenholz F.	1990	CALCA

Genes related to diabetes insipidus according to GeneCards:

(show top 50)    (show all 71)

id	Symbol	Description	Score	GeneCards Section Context
1	AVPR2	arginine vasopressin receptor 2	11.1	Publications, Orthologs, Summaries
2	AVP	arginine vasopressin	11.1	Summaries, Publications
3	AQP2	aquaporin 2 (collecting duct)	11.1	Publications, Summaries
4	ARHGAP4	Rho GTPase activating protein 4	11.1	Publications, Summaries
5	WFS1	Wolfram syndrome 1 (wolframin)	11.1	Publications, Summaries
6	LNPEP	leucyl/cystinyl aminopeptidase	11.0	Publications
7	OXT	oxytocin, prepropeptide	11.0
8	CLCNKA	chloride channel, voltage-sensitive Ka	11.0	Publications, Functions
9	MIP	major intrinsic protein of lens fiber	11.0	Publications
10	L1CAM	L1 cell adhesion molecule	11.0	Publications
11	AQP1	aquaporin 1 (Colton blood group)	11.0	Publications
12	SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	11.0	Publications
13	CASR	calcium-sensing receptor	11.0	Publications
14	POMC	proopiomelanocortin	11.0	Publications
15	PRL	prolactin	11.0	Publications
16	AQP12A	aquaporin 12A	11.0
17	NPTX2	neuronal pentraxin II	11.0	Publications
18	BSND	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	11.0	Publications
19	AQP8	aquaporin 8	11.0
20	AVPR1B	arginine vasopressin receptor 1B	11.0	Orthologs
21	AQP11	aquaporin 11	11.0
22	AQP6	aquaporin 6, kidney specific	11.0
23	MRGPRX1	MAS-related GPR, member X1	11.0	Publications
24	GPBAR1	G protein-coupled bile acid receptor 1	11.0	Publications
25	AVPR1A	arginine vasopressin receptor 1A	11.0	Orthologs
26	ARHGAP1	Rho GTPase activating protein 1	11.0	Publications
27	AQP7	aquaporin 7	11.0
28	AQP3	aquaporin 3 (Gill blood group)	11.0
29	AQP4	aquaporin 4	11.0
30	OXER1	oxoeicosanoid (OXE) receptor 1	11.0
31	OXTR	oxytocin receptor	11.0	Orthologs
32	CANX	calnexin	11.0	Publications
33	NPPA	natriuretic peptide A	11.0	Publications
34	CRH	corticotropin releasing hormone	11.0	Publications
35	REN	renin	11.0	Publications
36	PLAT	plasminogen activator, tissue	11.0	Publications
37	VWF	von Willebrand factor	11.0	Publications
38	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
39	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
40	AGTR1	angiotensin II receptor, type 1	11.0	Publications
41	F8	coagulation factor VIII, procoagulant component	11.0	Publications
42	ADCY2	adenylate cyclase 2 (brain)	11.0
43	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
44	CISD2	CDGSH iron sulfur domain 2	11.0
45	UBOX5	U-box domain containing 5	11.0	Disorders
46	CLCNKB	chloride channel, voltage-sensitive Kb	11.0	Publications
47	AQP10	aquaporin 10	11.0
48	UCN	urocortin	11.0	Publications
49	CD1A	CD1a molecule	11.0
50	DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2	11.0

Pathways related to diabetes insipidus according to GeneDecks:

(show all 13)

id	Pathway	Score	Top Affiliating Genes
1	Vasopressin-regulated water reabsorption20	10.4	AQP4, AQP3, AQP2, AVPR2, AVP
2	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics34	10.3	UCN, CRH, POMC
3	G alpha (s) signalling events38	10.1	POMC, AVPR2, AVP, CGA
4	Adenylate cyclase-activating neuropeptides10	10.1	UCN, AVPR2, CALCA, ADCY2
5	Passive Transport by Aquaporins38	10.1	MIP, AQP8, AQP7, AQP6, AQP4, AQP3
6	G alpha (q) signalling events38	10.0	OXTR, OXT, AGTR1, TRH, GNRH1, AVPR1B
7	Renin-angiotensin system20	9.9	AGTR1, ACE, LNPEP, REN
8	Class B/2 (Secretin family receptors)38	9.8	CRH, PTHLH, GHRH, CALCA
9	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	9.8	OXTR, AGTR1, AVPR2, AVPR1B, AVPR1A
10	Neuroactive ligand-receptor interaction20	9.6	PRL, OXTR, TSHR, AGTR1, AVPR2, AVPR1B
11	eNOS Signaling36	9.4	AQP8, IGF1, GNRH1, GHRH, ADCY2, AQP7
12	Autoimmune thyroid disease20	9.3	CGA, TPO, TSHR, TG
13	Renin-Angiotensin Pathway36	9.0	ADCY2, AGTR1, ACE, GHRH, GNRH1, IGF1

Compounds related to diabetes insipidus according to GeneDecks:

(show top 50)    (show all 287)

id	Compound	Score	Top Affiliating Genes
1	methimazole32 9 9	11.9	TSHR, TRH, IGF1, VWF, POMC
2	desmopressin32 42 9 9	12.8	NPPA, POMC, VWF, REN, LNPEP, AVP
3	furosemide32 42 34 9 18 9	14.4	REN, BSND, AQP2, CALCA, ACE, AGTR1
4	pge232	9.4	CRH, OXTR, OXT, SLC12A1, ACP1, CASR
5	glucose32	9.4	UCN, S100B, CGB, AVP, MIP, AQP1
6	sodium nitroprusside32	9.3	CRH, REN, VWF, NPPA, AGTR1, ACP1
7	sodium32 18	10.1	TG, TSHR, AGTR1, TPO, CASR, AQP4
8	chloride32	9.0	SLC12A1, NPPA, TPO, CLCNKA, CLCNKB, BSND
9	quinapril32 9 9	10.9	AGTR1, NPPA, PLAT, CRP, ACE, REN
10	glycerol32 9 18 9	11.9	AQP2, AQP1, INS, MIP, VWF, NPPA
11	nacl32	8.8	CASR, F8, AQP2, AQP1, MIP, CLCNKA
12	spironolactone32 42 34 9 9	12.8	GNRH1, CYP21A2, POMC, AGTR1, ACE, NPPA
13	prostaglandin f2alpha32	8.8	IGF1, CRH, CRP, ACP1, OXT, OXTR
14	aspartate32	8.8	GHRH, F8, S100B, CGA, AVPR2, GNRH1
15	dehydroepiandrosterone sulfate32	8.7	POMC, GNRH1, OXTR, CRH, CYP21A2, UCN
16	clomiphene citrate32	8.6	AFP, PRL, CRH, CYP21A2, GNRH1, IGF1
17	gnrh32	8.6	CGB, MRGPRX1, INS, GPBAR1, IGF1, GHRH
18	cysteine32	8.5	MIP, AQP4, CGB, AVP, AVPR1A, AQP1
19	dopamine32 9 18 9	11.4	GNRH1, GPBAR1, CGA, S100B, UCN, REN
20	cyclic amp32 18	9.3	NPPA, ADCY2, MIP, TSHR, PTHLH, GPBAR1
21	hydrocortisone32 9 9	10.3	CALCA, IGF1, AQP2, INS, REN, POMC
22	glutamate32	8.3	SCG5, L1CAM, MIP, INS, AQP4, GNRH1
23	ribonucleic acid32	8.2	GNRH1, GHRH, CASR, CYP21A2, IGF1, CGA
24	estradiol32 9 18 9	11.1	PRL, OXTR, OXT, TSHR, AGTR1, PLAT
25	epinephrine32 9 18 9	10.9	REN, CGA, INS, AQP2, F8, GNRH1
26	octreotide32 42 9 9	10.9	ACP1, CRH, PTHLH, TRH, GHRH, CALCA
27	potassium32 9 18 9	10.9	CLCNKB, BSND, REN, TPO, CASR, AQP4
28	cyclosporin a32 42	8.8	F8, S100B, VWF, PLAT, ACP1, AGTR1
29	testosterone32 9 18 9	10.7	TPO, PRL, AFP, OXTR, OXT, SCG5
30	steroid32	7.6	OXT, CYP21A2, S100B, PTHLH, CGA, REN
31	progesterone32 42 9 18 9	11.6	OXT, TSHR, PLAT, CRH, CYP21A2, PTHLH
32	acth32	7.5	TPO, TRH, GHRH, CASR, GNRH1, IGF1
33	prednisolone32 9 9	9.4	CSF3, VWF, PTHLH, F8, MPO, TG
34	forskolin32 42 9 9	10.4	AQP2, AQP1, CGA, S100B, UCN, LNPEP
35	adenylate32	7.3	TG, TSHR, ACP1, PLAT, CRH, PTHLH
36	dexamethasone32 42 34 9 9	11.1	AGTR1, ACP1, CRH, CYP21A2, PTHLH, TRH
37	acetylcholine32 9 18 9	10.0	GAD1, POMC, TG, AGTR1, ACP1, CRP
38	nitric oxide32 9 18 9	10.0	TPO, PTHLH, ACE, AGTR1, OXT, OXTR
39	thyroxine32 18	7.6	CGA, VWF, REN, CYP21A2, PTHLH, TPO
40	creatinine32	6.2	PTHLH, TPO, CASR, F8, IGF1, AQP3
41	calcium32 9 18 9	9.1	CLCNKA, TRH, TPO, PTHLH, CYP21A2, AGTR1
42	vegf32	6.0	AGTR1, CALCA, F8, IGF1, AQP1, MIP
43	lactate32	5.9	CGB, CGA, OXT, S100B, VWF, TG
44	estrogen32	5.8	VWF, TSHR, TG, OXT, OXTR, PRL
45	norepinephrine32 9 18 9	8.6	NPPA, POMC, PRL, OXT, TG, AGTR1
46	serine32	5.6	TG, TSHR, AGTR1, AFP, OXER1, OXT
47	arginine32	5.6	GAD1, POMC, SOD1, PRL, OXTR, OXT
48	alanine32	5.5	VWF, SCG5, S100B, CGA, SOD1, POMC
49	tyrosine32	5.5	TG, AFP, GAD1, CSF3, OXTR, OXER1
50	lipid32	5.0	OXTR, F8, GPBAR1, AQP1, MIP, S100B

Cellular components related to diabetes insipidus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intracellular canaliculus	GO:046691	10.4	MIP, AQP8
2	secretory granule	GO:030141	8.6	POMC, OXT, PLAT, TRH, INS, MPO
3	integral to plasma membrane	GO:005887	8.5	AQP6, AQP7, AQP8, CASR, TPO, AGTR1
4	plasma membrane	GO:005886	6.5	ACE, TPO, TRH, CASR, F8, AGTR1
5	extracellular space	GO:005615	5.5	CRP, PLAT, ACE, OXT, SOD1, CSF3
6	extracellular region	GO:005576	5.3	NPTX2, TRH, PTHLH, CRH, CRP, PLAT

Biological processes related to diabetes insipidus according to GeneDecks:

(show all 33)

id	Name	GO ID	Score	Top Affiliating Genes
1	multicellular organismal water homeostasis	GO:050891	10.7	AVP, AQP1, AQP4
2	maternal aggressive behavior	GO:002125	10.7	OXT, AVPR1A, AVP
3	positive regulation of cellular pH reduction	GO:032849	10.6	AVPR1B, AVPR1A, AVP
4	positive regulation of systemic arterial blood pressure	GO:003084	10.6	AVPR2, AVPR1A, AVP
5	glycerol transport	GO:015793	10.6	AQP7, AQP2, AQP11, AQP1
6	hyperosmotic salinity response	GO:042538	10.6	OXT, AVPR1B, AVP
7	maternal behavior	GO:042711	10.6	OXTR, OXT, AVPR1A, AVP
8	sperm ejaculation	GO:042713	10.6	OXTR, OXT, AVPR1A
9	positive regulation of glutamate secretion	GO:014049	10.6	AVP, AVPR1A, AVPR1B
10	renal water absorption	GO:070295	10.5	AQP7, AQP4, AQP3
11	drinking behavior	GO:042756	10.5	OXT, UCN, REN
12	grooming behavior	GO:007625	10.4	AVP, AVPR1A, OXT
13	social behavior	GO:035176	10.4	AVP, AVPR1A, OXT, OXTR
14	renal water transport	GO:003097	10.3	AQP1, AQP2
15	excretion	GO:007588	10.3	AQP7, AQP6, AQP4, AQP3, AQP2, AVPR2
16	telencephalon development	GO:021537	10.3	OXTR, AVPR2, AVPR1A
17	generation of precursor metabolites and energy	GO:006091	10.2	AVP, AVPR1A, AQP7, POMC
18	positive regulation of cAMP biosynthetic process	GO:030819	10.2	PTHLH, GHRH, CALCA, AVP
19	peptide hormone processing	GO:016486	10.1	POMC, CGB, CGA, SCG5
20	cellular response to water deprivation	GO:042631	10.1	AVPR1A, AQP2
21	elevation of cytosolic calcium ion concentration	GO:007204	10.1	OXTR, OXT, AGTR1, GHRH, CALCA, AVPR1B
22	transmembrane transport	GO:055085	9.9	AQP6, AQP7, AQP8, SLC12A1, ADCY2, AQP4
23	female pregnancy	GO:007565	9.9	NPPA, PRL, OXTR, OXT, CRH, PTHLH
24	water transport	GO:006833	9.9	AVP, ADCY2, AQP8, AQP7, AQP6, AQP4
25	transport	GO:006810	9.9	AFP, SLC12A1, AQP8, AQP6, AQP4, AQP3
26	adenylate cyclase-activating G-protein coupled receptor signaling pathway	GO:007189	9.9	ADCY2, TSHR, PTHLH, GHRH, CALCA
27	kidney development	GO:001822	9.8	WFS1, AGTR1, ACE, AQP11, REN
28	regulation of blood pressure	GO:008217	9.5	NPPA, POMC, SOD1, ACE, CALCA, REN
29	positive regulation of vasodilation	GO:045909	9.4	UCN, INS, CALCA
30	G-protein coupled receptor signaling pathway	GO:007186	9.0	OXER1, TSHR, AGTR1, CASR, INS, AVPR1B
31	acute-phase response	GO:006953	9.0	CRP, F8, INS, MRGPRX1
32	cell-cell signaling	GO:007267	8.2	GHRH, TRH, PTHLH, TSHR, POMC, CALCA
33	positive regulation of cell proliferation	GO:008284	8.0	CSF3, DNAJA2, TSHR, PTHLH, GHRH, IGF1

Molecular functions related to diabetes insipidus according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	water transmembrane transporter activity	GO:005372	10.5	AQP1, AQP2, AQP4
2	vasopressin receptor activity	GO:005000	10.4	AVPR1A, AVPR1B, AVPR2, OXTR
3	neurohypophyseal hormone activity	GO:005185	10.4	AVP, OXT
4	V1A vasopressin receptor binding	GO:031894	10.4	AVP, AVPR1A
5	water channel activity	GO:015250	10.3	AQP8, AQP7, AQP6, AQP3, AQP1, MIP
6	glycerol transmembrane transporter activity	GO:015168	10.3	AQP1, AQP2
7	transporter activity	GO:005215	10.1	WFS1, AQP3, AQP12A, AQP11, AQP10, MIP
8	neuropeptide hormone activity	GO:005184	10.1	CRH, TRH, AVP, UCN
9	bradykinin receptor binding	GO:031711	9.5	ACE, AGTR1
10	insulin-like growth factor receptor binding	GO:005159	9.5	IGF1, INS, REN
11	hormone activity	GO:005179	8.2	CGA, NPPA, POMC, PRL, TG, CRH