MCID: DBT005
MIFTS: 58

Diabetes Insipidus malady

Endocrine diseases, Nephrological diseases, Rare diseases, Neuronal diseases categories
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Summaries for Diabetes Insipidus

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MedlinePlus:33 Diabetes insipidus (di) causes frequent urination. you become extremely thirsty, so you drink. then you urinate. this cycle can keep you from sleeping or even make you wet the bed. your body produces lots of urine that is almost all water. di is different from diabetes mellitus (dm), which involves insulin problems and high blood sugar. the symptoms can be similar. however, di is related to how your kidneys handle fluids. it's much less common than dm. urine and blood tests can show which one you have. usually, di is caused by a problem with your pituitary gland or your kidneys. treatment depends on the cause of the problem. medicines can often help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Diabetes Insipidus, also known as central diabetes insipidus, is related to nephrogenic diabetes insipidus and neurogenic diabetes insipidus. An important gene associated with Diabetes Insipidus is AVPR2 (arginine vasopressin receptor 2), and among its related pathways are Vasopressin-regulated water reabsorption and Diuretics Pathway, Pharmacodynamics. The compounds d[leu4,lys8]-vp and (d(ch2)51,tyr(me)2,arg8)-vasopressin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, kidney and testes, and related mouse phenotypes are renal/urinary system and integument.

Wikipedia:65 Diabetes insipidus (DI) is a condition characterized by excessive thirst and excretion of large amounts... more...

Aliases & Classifications for Diabetes Insipidus

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Diabetes Insipidus, Aliases & Descriptions:

Name: Diabetes Insipidus 8 10 33
 
Central Diabetes Insipidus 62


Classifications:



External Ids:

Disease Ontology8 DOID:9409
ICD9CM27 253.5
NCIt39 C43263
SNOMED-CT57 15771004, 190484000
MeSH34 D003919
ICD1025 E23.2

Related Diseases for Diabetes Insipidus

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Diseases in the Diabetes Insipidus family:

Acquired Central Diabetes Insipidus

Diseases related to Diabetes Insipidus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 279)
idRelated DiseaseScoreTop Affiliating Genes
1nephrogenic diabetes insipidus32.6AVPR2, AQP2
2neurogenic diabetes insipidus31.7AQP2, AVP, AVPR2
3hypopituitarism31.4AQP2, AVP
4syndrome of inappropriate antidiuretic hormone31.1AVPR2, AVP, AQP2
5nephrogenic syndrome of inappropriate antidiuresis30.8AVPR2
6l1 syndrome30.6L1CAM
7hydrocephalus30.4AQP1, L1CAM
8polyhydramnios30.1SLC12A1, AQP1
9cystic fibrosis29.9AQP2, AQP1, MIP
10neurohypophyseal diabetes insipidus11.0
11panhypopituitarism10.8
12diabetes mellitus10.7
13histiocytosis10.7
14langerhans-cell histiocytosis10.7
15leukemia10.7
16optic atrophy10.7
17gestational diabetes insipidus10.7
18lymphocytic hypophysitis10.7
19wolfram syndrome10.6
20germinoma10.6
21renal tubular acidosis10.5
22gestational diabetes10.5
23cerebritis10.5
24myeloid leukemia10.5
25acute myeloid leukemia10.5
26brain injury10.5
27traumatic brain injury10.5
28fanconi syndrome10.5
29neuronitis10.5
30hydronephrosis10.5
31pituitary apoplexy10.5
32encephalitis10.5
33thyroiditis10.5
34dipsogenic diabetes insipidus10.5
35acquired central diabetes insipidus10.5
36craniopharyngioma10.4
37meningitis10.4
38neurosarcoidosis10.4
39meniere's disease10.4MIP
40holoprosencephaly10.4
41congenital toxoplasmosis10.4
42hellp syndrome10.4
43hypothyroidism10.4
44lung cancer10.4
45sarcoidosis10.4
46toxoplasmosis10.4
47septo-optic dysplasia10.4
48nephrocalcinosis10.3
49erdheim-chester disease10.3
50wegener's granulomatosis10.3

Graphical network of the top 20 diseases related to Diabetes Insipidus:



Diseases related to diabetes insipidus

Symptoms for Diabetes Insipidus

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Drugs & Therapeutics for Diabetes Insipidus

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Drug clinical trials:

Search ClinicalTrials for Diabetes Insipidus

Search NIH Clinical Center for Diabetes Insipidus

Genetic Tests for Diabetes Insipidus

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Anatomical Context for Diabetes Insipidus

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MalaCards organs/tissues related to Diabetes Insipidus:

32
Pituitary, Kidney, Testes, Brain, Myeloid, Thyroid, Liver, Lung, Bone, Hypothalamus, Pineal, Heart, Breast, Prostate, T cells, B cells, Bone marrow, Eye, Skin, Placenta, Monocytes, Neutrophil

Animal Models for Diabetes Insipidus or affiliated genes

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MGI Mouse Phenotypes related to Diabetes Insipidus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.7SLC12A1, AQP1, AQP2, CLCNKA, AVP, AVPR2
2MP:00107717.6AVPR2, L1CAM, AQP2, WFS1, SLC12A1
3MP:00053787.4SLC12A1, WFS1, AQP1, AQP2, L1CAM, AVPR2
4MP:00053767.2AVPR2, AVP, CLCNKA, AQP2, AQP1, WFS1
5MP:00053867.1AVPR2, AVP, L1CAM, AQP2, AQP1, WFS1
6MP:00107687.0AVPR2, AVP, L1CAM, AQP2, AQP1, WFS1

Publications for Diabetes Insipidus

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Articles related to Diabetes Insipidus:

(show top 50)    (show all 1119)
idTitleAuthorsYear
1
Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration". (24944199)
2014
2
Combination of secretin and fluvastatin ameliorates the polyuria associated with X-linked nephrogenic diabetes insipidus in mice. (24522493)
2014
3
From cerebral salt wasting to diabetes insipidus with adipsia: case report of a child with craniopharyngioma. (25210759)
2014
4
Diabetes Insipidus in Pediatric Patients. (25371144)
2014
5
Pulmonary thrombosis associated with antidiuretic hormone replacement therapy due to secondary diabetes insipidus after traumatic brain injury: A case report. (23131855)
2013
6
Pheochromocytoma presenting as diabetes insipidus. (24382904)
2013
7
Central diabetes insipidus in pediatric severe traumatic brain injury. (23314181)
2013
8
Incidence, predictors and early post-operative course of diabetes insipidus in paediatric craniopharygioma: a comparison with adults. (23386174)
2013
9
Nephrogenic diabetes insipidus with intracranial calcification in a child with thalassemia minor. (24053747)
2013
10
Hypernatremia-associated coma caused by glucocorticoid replacement for adrenal crisis in an unrecognized central diabetes insipidus patient. (24018158)
2013
11
Hypopituitarism and central diabetes insipidus: perioperative diagnosis and management. (23040752)
2012
12
Metastatic prostate adenocarcinoma presenting central diabetes insipidus. (22474455)
2012
13
Panhypopituitarism and diabetes insipidus in a patient with primary central nervous system lymphoma. (22563813)
2012
14
Central diabetes insipidus and hypothalamic type of hypopituitarism associated with atypical location of Rathke's cleft cyst. (22246489)
2012
15
Management of diabetes insipidus in children. (22029022)
2011
16
Central diabetes insipidus in association with neonatal brain abscess. (20480721)
2010
17
Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by (1)H-NMR-based metabonomics. (19923409)
2010
18
Septo-optic dysplasia plus: a patient with diabetes insipidus. (20682211)
2010
19
Hypothalamic obesity complicated by adipsic central diabetes insipidus following surgical resection of a craniopharyngioma. (19817945)
2009
20
Permanent central diabetes insipidus after mild traumatic brain injury. (19891534)
2009
21
Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus. (19367330)
2009
22
Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus. (19729439)
2009
23
Central diabetes insipidus misdiagnosed as acute gastroenteritis in a pediatric patient. (18826743)
2008
24
Diabetes insipidus caused by pituitary gland metastasis accompanied by iris metastasis of small cell lung cancer: case presentation and review of the literature. (19112958)
2008
25
Identification of two novel aquaporin-2 mutations in a Thai girl with congenital nephrogenic diabetes insipidus. (18473191)
2008
26
Microvascular diabetes complications in Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness [DIDMOAD]): an age- and duration-matched comparison with common type 1 diabetes. (17536072)
2007
27
Adipsic diabetes insipidus following pituitary surgery for a macroprolactinoma. (16703410)
2006
28
Gene symbol: AVP. Disease: Diabetes insipidus, neurohypophyseal. Accession #Hm0560. (17297716)
2006
29
Wegener's granulomatosis presenting as diabetes insipidus. (17115352)
2006
30
Minor disturbances in central nervous system function in familial neurohypophysial diabetes insipidus. (16125866)
2006
31
The value of urine specific gravity in detecting diabetes insipidus in a patient with uncontrolled diabetes mellitus: urine specific gravity in differential diagnosis. (17026722)
2006
32
Serial T1-weighted magnetic resonance imaging changes in a patient with central diabetes insipidus, possibly due to lymphocytic infundibuloneurohypophysitis. (16322406)
2005
33
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. (16508710)
2005
34
Methotrexate-induced nephrogenic diabetes insipidus: first case report. (11886979)
2002
35
Lithium-induced nephrogenic diabetes insipidus in older people. (11509315)
2001
36
Lithium-induced nephrogenic diabetes insipidus. (11246113)
2001
37
Misfolded vasopressin V2 receptors caused by extracellular point mutations entail congenital nephrogenic diabetes insipidus. (11026555)
2000
38
Familial neurohypophyseal diabetes insipidus associated with a novel mutation in the vasopressin-neurophysin II gene. (10677561)
2000
39
Evolution of childhood central diabetes insipidus into panhypopituitarism with a large hypothalamic mass: is 'lymphocytic infundibuloneurohypophysitis' in children a different entity? (9916870)
1998
40
Identification of mutations of the arginine vasopressin-neurophysin II gene in two kindreds with familial central diabetes insipidus. (9467595)
1998
41
Autosomal dominant neurohypophyseal diabetes insipidus associated with a missense mutation encoding Gly23-->Val in neurophysin II. (9360520)
1997
42
Congenital microgastria, growth hormone deficiency and diabetes insipidus. (9007489)
1997
43
Heterologous expression of human vasopressin-neurophysin precursors in a pituitary cell line: defective transport of a mutant protein from patients with familial diabetes insipidus. (8945633)
1996
44
Nephrogenic diabetes insipidus secondary to lithium therapy in the postoperative patient: a case report. (7978676)
1994
45
Optic atrophy, diabetes mellitus and diabetes insipidus. (3723871)
1986
46
Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus. (3970081)
1985
47
Nephrogenic diabetes insipidus associated with Dyazide (triamterene-hydrochlorothiazide). (6794799)
1981
48
Post-obstructive diuresis in nephrogenic diabetes insipidus associated with bladder neck obstruction. (423345)
1979
49
Primary empty sella syndrome with panhypopituitarism, diabetes insipidus, and visual field defects. (707005)
1978
50
Diabetes insipidus and panhypopituitarism after pituitary infarction in a case of acromegaly. (890301)
1977

Variations for Diabetes Insipidus

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Expression for genes affiliated with Diabetes Insipidus

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Expression patterns in normal tissues for genes affiliated with Diabetes Insipidus

Search GEO for disease gene expression data for Diabetes Insipidus.

Pathways for genes affiliated with Diabetes Insipidus

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Pathways related to Diabetes Insipidus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4AQP2, AVP, AVPR2
29.2SLC12A1, CLCNKA
3
Show member pathways
8.4AVPR2, AVP, AQP2, AQP1, MIP
4
Show member pathways
7.1SLC12A1, MIP, AQP1, AQP2, CLCNKA, AVP

Compounds for genes affiliated with Diabetes Insipidus

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Compounds related to Diabetes Insipidus according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1d[leu4,lys8]-vp6110.2AVPR2, AVP
2(d(ch2)51,tyr(me)2,arg8)-vasopressin6110.2AVPR2, AVP
3[arg8]-vasopressin6110.2AVPR2, AVP
4sr 4905961 2811.2AVP, AVPR2
5vas-a4410.0AQP1, AVPR2
6abscisic acid449.9AVP, MIP
7desmopressin44 61 28 1112.8AVPR2, AVP, AQP2
8hg2+449.8MIP, AQP1
9dids44 2810.8AQP1, CLCNKA
10pcmbs449.8MIP, AQP1
11tetraethylammonium44 28 1111.6AQP1, MIP
12histidine449.5AQP1, AVP, AVPR2
13furosemide44 61 28 50 24 1114.5SLC12A1, AQP2
14bicarbonate449.5MIP, AQP1
15hgcl2449.5AQP2, AQP1, MIP
16hg2+289.5MIP, AQP1, AQP2
17mercury449.5MIP, AQP1, AQP2
18glycerol44 24 1111.4AQP2, AQP1, MIP
19creatinine449.3AQP1, AQP2, AVP
20asparagine449.3AQP1, AVPR2
21silver449.3MIP, AQP1
22cyclic amp44 2410.3AVPR2, AQP2, MIP
23hydrogen44 2410.2AQP2, AQP1, MIP
24alanine449.2AVPR2, AVP, AQP2, AQP1
25dexamethasone44 50 28 1112.0MIP, AQP1, AQP2, AVP
26ammonium449.0SLC12A1, MIP, AQP1
27glucose449.0AVP, AQP2, AQP1, MIP
28glutamate448.9MIP, L1CAM, AVP, AVPR2
29forskolin44 50 1110.9SLC12A1, AQP1, AQP2
30magnesium44 24 1110.8SLC12A1, AQP2, CLCNKA
31arginine448.8AVPR2, AVP, AQP2, AQP1, MIP
32cysteine448.7AVPR2, AVP, AQP2, AQP1, MIP
33urea44 24 1110.6AQP2, AQP1, MIP, SLC12A1
34nitric oxide44 24 1110.3AVP, AQP2, AQP1, MIP, SLC12A1
35nacl448.2CLCNKA, AQP2, AQP1, MIP, SLC12A1
36potassium44 24 119.9AVPR2, CLCNKA, AQP2, AQP1, MIP, SLC12A1
37chloride447.5SLC12A1, AVPR2, AVP, CLCNKA, AQP2, AQP1
38sodium44 248.5AVPR2, AVP, CLCNKA, AQP2, AQP1, MIP
39calcium44 50 24 1110.1AVPR2, AVP, CLCNKA, AQP2, AQP1, MIP

GO Terms for genes affiliated with Diabetes Insipidus

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Cellular components related to Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7MIP, AQP1, CLCNKA, AVPR2
2plasma membraneGO:0058866.5SLC12A1, AVPR2, L1CAM, CLCNKA, AQP2, AQP1

Biological processes related to Diabetes Insipidus according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of systemic arterial blood pressureGO:0030849.9AVPR2, AVP
2renal water transportGO:0030979.8AQP1, AQP2
3cellular response to mercury ionGO:0712889.8AQP2, AQP1
4glycerol transportGO:0157939.8AQP1, AQP2
5cellular response to copper ionGO:0712809.8AQP1, AQP2
6multicellular organismal water homeostasisGO:0508919.8AVP, AQP1
7positive regulation of calcium ion transportGO:0519289.7WFS1, AQP2
8cell volume homeostasisGO:0068849.6AQP2, AQP1
9positive regulation of protein ubiquitinationGO:0313989.6WFS1, AVPR2
10excretionGO:0075889.6AQP2, CLCNKA, AVPR2
11negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.3AQP1, AVP
12potassium ion transportGO:0068139.1SLC12A1, AQP1
13water transportGO:0068338.7MIP, AQP1, AQP2, AVP, AVPR2
14transmembrane transportGO:0550857.4AVPR2, AVP, CLCNKA, AQP2, AQP1, MIP

Molecular functions related to Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycerol transmembrane transporter activityGO:0151689.5AQP1, AQP2
2water channel activityGO:0152509.4MIP, AQP1
3water transmembrane transporter activityGO:0053729.3AQP1, AQP2

Products for genes affiliated with Diabetes Insipidus

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Sources for Diabetes Insipidus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet