MCID: DBT005
MIFTS: 52

Diabetes Insipidus malady

Endocrine diseases, Rare diseases, Neuronal diseases categories

Summaries for Diabetes Insipidus

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MedlinePlus:32 Diabetes insipidus (di) causes frequent urination. you become extremely thirsty, so you drink. then you urinate. this cycle can keep you from sleeping or even make you wet the bed. your body produces lots of urine that is almost all water. di is different from diabetes mellitus (dm), which involves insulin problems and high blood sugar. the symptoms can be similar. however, di is related to how your kidneys handle fluids. it's much less common than dm. urine and blood tests can show which one you have. usually, di is caused by a problem with your pituitary gland or your kidneys. treatment depends on the cause of the problem. medicines can often help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Diabetes Insipidus, also known as central diabetes insipidus, is related to diabetes insipidus, nephrogenic and diabetes insipidus, neurohypophyseal. An important gene associated with Diabetes Insipidus is AVPR2 (arginine vasopressin receptor 2), and among its related pathways are Vasopressin-regulated water reabsorption and Diuretics Pathway, Pharmacodynamics. The drugs desmopressin and desmopressin acetate and the compounds d[leu4,lys8]-vp and (d(ch2)51,tyr(me)2,arg8)-vasopressin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, kidney and testes, and related mouse phenotypes are renal/urinary system and integument.

Wikipedia:63 Diabetes insipidus (DI) is a condition characterized by excessive thirst and excretion of large amounts... more...

Aliases & Classifications for Diabetes Insipidus

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Diabetes Insipidus, Aliases & Descriptions:

Name: Diabetes Insipidus 9 11 32 60
 
Central Diabetes Insipidus 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases, Neuronal diseases


External Ids:

Disease Ontology9 DOID:9409
MeSH33 D003919
ICD9CM27 253.5
SNOMED-CT55 15771004, 190484000
NCIt38 C43263
ICD1025 E23.2

Related Diseases for Diabetes Insipidus

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Diseases in the Diabetes Insipidus family:

Hereditary Central Diabetes Insipidus Acquired Central Diabetes Insipidus

Diseases related to Diabetes Insipidus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 264)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus, nephrogenic31.9AVPR2, AQP2
2diabetes insipidus, neurohypophyseal31.6AQP2, AVP, AVPR2
3hypopituitarism31.4AQP2, AVP
4syndrome of inappropriate antidiuretic hormone31.0AVPR2, AVP, AQP2
5nephrogenic syndrome of inappropriate antidiuresis30.8AVPR2
6hydrocephalus30.4AQP1, L1CAM
7polyhydramnios30.1SLC12A1, AQP1
8cystic fibrosis29.9AQP2, AQP1, MIP
9neurogenic diabetes insipidus10.9
10langerhans-cell histiocytosis10.7
11histiocytosis10.7
12wolfram syndrome10.7
13leukemia10.7
14gestational diabetes insipidus10.7
15lymphocytic hypophysitis10.6
16renal tubular acidosis10.6
17germinoma10.6
18cerebritis10.6
19myeloid leukemia10.5
20brain injury10.5
21traumatic brain injury10.5
22fanconi syndrome10.5
23neuronitis10.5
24acquired central diabetes insipidus10.5
25pituitary apoplexy10.5
26hydronephrosis10.5
27dipsogenic diabetes insipidus10.5
28hereditary central diabetes insipidus10.5
29encephalitis10.5
30neurosarcoidosis10.5
31holoprosencephaly10.4
32erdheim-chester disease10.4
33craniopharyngioma10.4
34hypothyroidism10.4
35meningitis10.4
36thyroiditis10.4
37lung cancer10.4
38congenital toxoplasmosis10.4
39hellp syndrome10.4
40toxoplasmosis10.4
41diabetes insipidus nephrogenic mental retardation and intracerebral calcification10.4
42meniere's disease10.4MIP
43optic nerve hypoplasia10.3
44rickets10.3
45nephrocalcinosis10.3
46empty sella syndrome10.3
47hyperparathyroidism10.3
48hypogonadism10.3
49xanthoma disseminatum10.3
50masa syndrome10.3L1CAM

Graphical network of the top 20 diseases related to Diabetes Insipidus:



Diseases related to diabetes insipidus

Symptoms for Diabetes Insipidus

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Drugs & Therapeutics for Diabetes Insipidus

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Drug clinical trials:

Search ClinicalTrials for Diabetes Insipidus

Search NIH Clinical Center for Diabetes Insipidus

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Diabetes Insipidus

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Anatomical Context for Diabetes Insipidus

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MalaCards organs/tissues related to Diabetes Insipidus:

31
Pituitary, Kidney, Testes, Brain, Myeloid, Liver, Lung, Thyroid, Bone, Hypothalamus, Pineal, Heart, Breast, Prostate, T cells, B cells, Bone marrow, Eye, Skin, Placenta, Monocytes, Neutrophil

Animal Models for Diabetes Insipidus or affiliated genes

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MGI Mouse Phenotypes related to Diabetes Insipidus:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.7SLC12A1, AQP1, AQP2, CLCNKA, AVP, AVPR2
2MP:00107717.6AVPR2, L1CAM, AQP2, WFS1, SLC12A1
3MP:00053787.4SLC12A1, WFS1, AQP1, AQP2, L1CAM, AVPR2
4MP:00053767.2AVPR2, AVP, CLCNKA, AQP2, AQP1, WFS1
5MP:00053867.1AVPR2, AVP, L1CAM, AQP2, AQP1, WFS1
6MP:00107687.0AVPR2, AVP, L1CAM, AQP2, AQP1, WFS1

Publications for Diabetes Insipidus

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Articles related to Diabetes Insipidus:

(show top 50)    (show all 1138)
idTitleAuthorsYear
1
Acute fatty liver of pregnancy with hypoglycaemia, diabetes insipidus and pancreatitis, preceded by intrahepatic cholestasis of pregnancy. (25878236)
2015
2
Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration". (24944199)
2014
3
Combination of secretin and fluvastatin ameliorates the polyuria associated with X-linked nephrogenic diabetes insipidus in mice. (24522493)
2014
4
From cerebral salt wasting to diabetes insipidus with adipsia: case report of a child with craniopharyngioma. (25210759)
2014
5
Diabetes Insipidus in Pediatric Patients. (25371144)
2014
6
Pulmonary thrombosis associated with antidiuretic hormone replacement therapy due to secondary diabetes insipidus after traumatic brain injury: A case report. (23131855)
2013
7
Pheochromocytoma presenting as diabetes insipidus. (24382904)
2013
8
Central diabetes insipidus in pediatric severe traumatic brain injury. (23314181)
2013
9
Incidence, predictors and early post-operative course of diabetes insipidus in paediatric craniopharygioma: a comparison with adults. (23386174)
2013
10
Nephrogenic diabetes insipidus with intracranial calcification in a child with thalassemia minor. (24053747)
2013
11
Hypernatremia-associated coma caused by glucocorticoid replacement for adrenal crisis in an unrecognized central diabetes insipidus patient. (24018158)
2013
12
Hypopituitarism and central diabetes insipidus: perioperative diagnosis and management. (23040752)
2012
13
Remarkable cystic expansion of microprolactinoma causing diabetes insipidus during pregnancy. (22593591)
2012
14
Metastatic prostate adenocarcinoma presenting central diabetes insipidus. (22474455)
2012
15
Panhypopituitarism and diabetes insipidus in a patient with primary central nervous system lymphoma. (22563813)
2012
16
Central diabetes insipidus and hypothalamic type of hypopituitarism associated with atypical location of Rathke's cleft cyst. (22246489)
2012
17
Management of diabetes insipidus in children. (22029022)
2011
18
Central diabetes insipidus in association with neonatal brain abscess. (20480721)
2010
19
Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by (1)H-NMR-based metabonomics. (19923409)
2010
20
Septo-optic dysplasia plus: a patient with diabetes insipidus. (20682211)
2010
21
Hypothalamic obesity complicated by adipsic central diabetes insipidus following surgical resection of a craniopharyngioma. (19817945)
2009
22
Permanent central diabetes insipidus after mild traumatic brain injury. (19891534)
2009
23
Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus. (19367330)
2009
24
Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus. (19729439)
2009
25
Central diabetes insipidus misdiagnosed as acute gastroenteritis in a pediatric patient. (18826743)
2008
26
Diabetes insipidus caused by pituitary gland metastasis accompanied by iris metastasis of small cell lung cancer: case presentation and review of the literature. (19112958)
2008
27
Identification of two novel aquaporin-2 mutations in a Thai girl with congenital nephrogenic diabetes insipidus. (18473191)
2008
28
Adipsic diabetes insipidus following pituitary surgery for a macroprolactinoma. (16703410)
2006
29
Gene symbol: AVP. Disease: Diabetes insipidus, neurohypophyseal. Accession #Hm0560. (17297716)
2006
30
Wegener's granulomatosis presenting as diabetes insipidus. (17115352)
2006
31
Minor disturbances in central nervous system function in familial neurohypophysial diabetes insipidus. (16125866)
2006
32
The value of urine specific gravity in detecting diabetes insipidus in a patient with uncontrolled diabetes mellitus: urine specific gravity in differential diagnosis. (17026722)
2006
33
Serial T1-weighted magnetic resonance imaging changes in a patient with central diabetes insipidus, possibly due to lymphocytic infundibuloneurohypophysitis. (16322406)
2005
34
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. (16508710)
2005
35
Methotrexate-induced nephrogenic diabetes insipidus: first case report. (11886979)
2002
36
Lithium-induced nephrogenic diabetes insipidus in older people. (11509315)
2001
37
Lithium-induced nephrogenic diabetes insipidus. (11246113)
2001
38
Misfolded vasopressin V2 receptors caused by extracellular point mutations entail congenital nephrogenic diabetes insipidus. (11026555)
2000
39
Familial neurohypophyseal diabetes insipidus associated with a novel mutation in the vasopressin-neurophysin II gene. (10677561)
2000
40
Evolution of childhood central diabetes insipidus into panhypopituitarism with a large hypothalamic mass: is 'lymphocytic infundibuloneurohypophysitis' in children a different entity? (9916870)
1998
41
Autosomal dominant neurohypophyseal diabetes insipidus associated with a missense mutation encoding Gly23-->Val in neurophysin II. (9360520)
1997
42
Congenital microgastria, growth hormone deficiency and diabetes insipidus. (9007489)
1997
43
Heterologous expression of human vasopressin-neurophysin precursors in a pituitary cell line: defective transport of a mutant protein from patients with familial diabetes insipidus. (8945633)
1996
44
Nephrogenic diabetes insipidus secondary to lithium therapy in the postoperative patient: a case report. (7978676)
1994
45
Optic atrophy, diabetes mellitus and diabetes insipidus. (3723871)
1986
46
Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus. (3970081)
1985
47
Nephrogenic diabetes insipidus associated with Dyazide (triamterene-hydrochlorothiazide). (6794799)
1981
48
Post-obstructive diuresis in nephrogenic diabetes insipidus associated with bladder neck obstruction. (423345)
1979
49
Primary empty sella syndrome with panhypopituitarism, diabetes insipidus, and visual field defects. (707005)
1978
50
Diabetes insipidus and panhypopituitarism after pituitary infarction in a case of acromegaly. (890301)
1977

Variations for Diabetes Insipidus

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Expression for genes affiliated with Diabetes Insipidus

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Search GEO for disease gene expression data for Diabetes Insipidus.

Pathways for genes affiliated with Diabetes Insipidus

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Pathways related to Diabetes Insipidus according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4AQP2, AVP, AVPR2
29.2SLC12A1, CLCNKA
3
Show member pathways
8.4AVPR2, AVP, AQP2, AQP1, MIP
4
Show member pathways
7.1SLC12A1, MIP, AQP1, AQP2, CLCNKA, AVP

Compounds for genes affiliated with Diabetes Insipidus

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Compounds related to Diabetes Insipidus according to GeneCards Suite gene sharing:

(show all 39)
idCompoundScoreTop Affiliating Genes
1d[leu4,lys8]-vp5910.2AVPR2, AVP
2(d(ch2)51,tyr(me)2,arg8)-vasopressin5910.2AVPR2, AVP
3[arg8]-vasopressin5910.2AVPR2, AVP
4sr 4905959 2811.2AVP, AVPR2
5vas-a4310.0AQP1, AVPR2
6abscisic acid439.9AVP, MIP
7desmopressin43 59 28 1212.8AVPR2, AVP, AQP2
8hg2+439.8MIP, AQP1
9dids43 2810.8AQP1, CLCNKA
10pcmbs439.8MIP, AQP1
11tetraethylammonium43 28 1211.6AQP1, MIP
12histidine439.5AQP1, AVP, AVPR2
13furosemide43 59 28 49 24 1214.5SLC12A1, AQP2
14bicarbonate439.5MIP, AQP1
15hgcl2439.5AQP2, AQP1, MIP
16hg2+289.5MIP, AQP1, AQP2
17mercury439.5MIP, AQP1, AQP2
18glycerol43 24 1211.4AQP2, AQP1, MIP
19creatinine439.3AQP1, AQP2, AVP
20asparagine439.3AQP1, AVPR2
21silver439.3MIP, AQP1
22cyclic amp43 2410.3AVPR2, AQP2, MIP
23hydrogen43 2410.2AQP2, AQP1, MIP
24alanine439.2AVPR2, AVP, AQP2, AQP1
25dexamethasone43 49 28 1212.0MIP, AQP1, AQP2, AVP
26ammonium439.0SLC12A1, MIP, AQP1
27glucose439.0AVP, AQP2, AQP1, MIP
28glutamate438.9MIP, L1CAM, AVP, AVPR2
29forskolin43 49 1210.9SLC12A1, AQP1, AQP2
30magnesium43 24 1210.8SLC12A1, AQP2, CLCNKA
31arginine438.8AVPR2, AVP, AQP2, AQP1, MIP
32cysteine438.7AVPR2, AVP, AQP2, AQP1, MIP
33urea43 24 1210.6AQP2, AQP1, MIP, SLC12A1
34nitric oxide43 24 1210.3AVP, AQP2, AQP1, MIP, SLC12A1
35nacl438.2CLCNKA, AQP2, AQP1, MIP, SLC12A1
36potassium43 24 129.9AVPR2, CLCNKA, AQP2, AQP1, MIP, SLC12A1
37chloride437.5SLC12A1, AVPR2, AVP, CLCNKA, AQP2, AQP1
38sodium43 248.5AVPR2, AVP, CLCNKA, AQP2, AQP1, MIP
39calcium43 49 24 1210.1AVPR2, AVP, CLCNKA, AQP2, AQP1, MIP

GO Terms for genes affiliated with Diabetes Insipidus

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Cellular components related to Diabetes Insipidus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.7MIP, AQP1, CLCNKA, AVPR2
2plasma membraneGO:00058866.5SLC12A1, AVPR2, L1CAM, CLCNKA, AQP2, AQP1

Biological processes related to Diabetes Insipidus according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of systemic arterial blood pressureGO:00030849.9AVPR2, AVP
2renal water transportGO:00030979.8AQP1, AQP2
3cellular response to mercury ionGO:00712889.8AQP2, AQP1
4glycerol transportGO:00157939.8AQP1, AQP2
5cellular response to copper ionGO:00712809.8AQP1, AQP2
6multicellular organismal water homeostasisGO:00508919.8AVP, AQP1
7positive regulation of calcium ion transportGO:00519289.7WFS1, AQP2
8cell volume homeostasisGO:00068849.6AQP2, AQP1
9positive regulation of protein ubiquitinationGO:00313989.6WFS1, AVPR2
10excretionGO:00075889.6AQP2, CLCNKA, AVPR2
11negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.3AQP1, AVP
12potassium ion transportGO:00068139.1SLC12A1, AQP1
13water transportGO:00068338.7MIP, AQP1, AQP2, AVP, AVPR2
14transmembrane transportGO:00550857.4AVPR2, AVP, CLCNKA, AQP2, AQP1, MIP

Molecular functions related to Diabetes Insipidus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycerol transmembrane transporter activityGO:00151689.5AQP1, AQP2
2water channel activityGO:00152509.4MIP, AQP1
3water transmembrane transporter activityGO:00053729.3AQP1, AQP2

Products for genes affiliated with Diabetes Insipidus

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Sources for Diabetes Insipidus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet