MCID: DBT005
MIFTS: 57

Diabetes Insipidus malady

Endocrine diseases category

Summaries for Diabetes Insipidus

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Diabetes insipidus (di) causes frequent urination. you become extremely thirsty, so you drink. then you urinate. this cycle can keep you from sleeping or even make you wet the bed. your body produces lots of urine that is almost all water. di is different from diabetes mellitus (dm), which involves insulin problems and high blood sugar. the symptoms can be similar. however, di is related to how your kidneys handle fluids. it's much less common than dm. urine and blood tests can show which one you have. usually, di is caused by a problem with your pituitary gland or your kidneys. treatment depends on the cause of the problem. medicines can often help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diabetes Insipidus, also known as central diabetes insipidus, is related to nephrogenic diabetes insipidus and neurogenic diabetes insipidus. An important gene associated with Diabetes Insipidus is AVPR2 (arginine vasopressin receptor 2), and among its related pathways are Vasopressin-regulated water reabsorption and Vasopressin-like receptors. The compounds forskolin and hgcl2 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, kidney and testes, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Wikipedia:63 Diabetes insipidus (DI) is a condition characterized by excessive thirst and excretion of large amounts... more...

Aliases & Classifications for Diabetes Insipidus

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

diabetes insipidus 8 10 33
central diabetes insipidus 60


External Ids:

Disease Ontology8 DOID:9409
NCIt39 C43263
MeSH34 D003919
SNOMED-CT56 15771004, 190484000
ICD9CM27 253.5
ICD1025 E23.2

Related Diseases for Diabetes Insipidus

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Diabetes Insipidus family:

Acquired Central Diabetes Insipidus Congenital Central Diabetes Insipidus

Diseases related to Diabetes Insipidus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1nephrogenic diabetes insipidus32.0AVPR2, AQP2
2neurogenic diabetes insipidus31.2AVP, AVPR2, OXT, NPTX2, UBOX5, AQP2
3panhypopituitarism31.1AVP, PRL, POMC
4diabetes mellitus31.0CASR, WFS1, POMC
5hypopituitarism31.0POMC, AVP, PRL, AQP2
6pituitary apoplexy30.6PRL, POMC
7lung cancer30.5POMC
8hypothyroidism30.5POMC, OXT, AVP, CASR, PRL
9craniopharyngioma30.5POMC, PRL, AVP
10hyperparathyroidism30.4CASR
11empty sella syndrome30.4PRL, POMC
12amenorrhea30.3POMC, PRL
13hypercalcemia30.2CASR, AVPR2
14hydrocephalus30.2L1CAM, AQP1
15sheehan syndrome30.2POMC, PRL
16pituitary cancer30.2PRL, POMC
17l1 syndrome30.0L1CAM
18hypertension30.0AVP, POMC
19pancreatitis30.0CASR
20polyhydramnios30.0SLC12A1, OXT, AQP1
21nephrolithiasis30.0CASR
22anorexia nervosa30.0POMC, PRL, OXT
23cushing's syndrome30.0PRL, POMC
24neurohypophyseal diabetes insipidus11.0
25histiocytosis10.7
26optic atrophy10.6
27langerhans-cell histiocytosis10.6
28leukemia10.6
29wolfram syndrome10.6
30acute leukemia10.6
31hydronephrosis10.5
32renal tubular acidosis10.5
33cerebritis10.5
34neuronitis10.5
35gestational diabetes10.5
36myeloid leukemia10.5
37acute myeloid leukemia10.4
38gestational diabetes insipidus10.4
39fanconi syndrome10.4
40encephalitis10.4
41thyroiditis10.4
42meningitis10.4
43erdheim-chester disease10.3
44holoprosencephaly10.3
45sarcoidosis10.3
46dipsogenic diabetes insipidus10.3
47acquired central diabetes insipidus10.3
48hellp syndrome10.3
49wegener's granulomatosis10.3
50nephrocalcinosis10.3

Graphical network of the top 20 diseases related to Diabetes Insipidus:



Diseases related to diabetes insipidus

Clinical Features for Diabetes Insipidus

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Drugs & Therapeutics for Diabetes Insipidus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Diabetes Insipidus

Drug clinical trials:

Search ClinicalTrials for Diabetes Insipidus

Search NIH Clinical Center for Diabetes Insipidus

Search CenterWatch for Diabetes Insipidus

Genetic Tests for Diabetes Insipidus

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Anatomical Context for Diabetes Insipidus

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32MalaCards
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MalaCards organs/tissues related to Diabetes Insipidus:

32
Pituitary, Kidney, Testes, Brain, Myeloid, Thyroid, Liver, Lung, Bone, Pineal, Hypothalamus, Prostate, B cells, Breast, Heart, T cells, Monocytes, Placenta, Skin, Eye, Bone marrow

Animal Models for Diabetes Insipidus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetes Insipidus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2PRL, WFS1, POMC, OXT, AQP1, AQP12A
2MP:000536710.1CASR, POMC, OXT, CLCNKA, AVPR2, AVP
3MP:000538610.0AQP2, CASR, L1CAM, NPTX2, PRL, WFS1
4MP:00053769.8OXT, POMC, WFS1, PRL, CASR, CLCNKA
5MP:00107719.8CASR, L1CAM, PRL, WFS1, POMC, OXT

Publications for Diabetes Insipidus

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Sources:
50PubMed
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Articles related to Diabetes Insipidus:

(show top 50)    (show all 1099)
idTitleAuthorsYear
1
Treatment of nephrogenic diabetes insipidus due to hypervitaminosis D. (23756934)
2013
2
Acute diabetes insipidus mediated by vasopressinase after placental abruption. (23393172)
2013
3
Central Diabetes Insipidus in Children and Young Adults: Etiological Diagnosis and Long - Term Outcome of Idiopathic Cases. (24276447)
2013
4
Novel compound aquaporin 2 mutations in nephrogenic diabetes insipidus. (22249485)
2012
5
Profound hypernatremia due to central diabetes insipidus. (22630107)
2012
6
Nonobstructive urinary tract dilatation in children with diabetes insipidus. (22498392)
2012
7
Central diabetes insipidus presenting as an early sign of acute myeloid leukemia. (22895245)
2012
8
Diabetes insipidus as an atypical presentation of acute myeloid leukemia. (22424594)
2012
9
Sheehan syndrome presenting as central diabetes insipidus: a rare presentation of an uncommon disorder. (21041172)
2011
10
Langerhans' cell histiocytosis (LCH) in adolescence presented with central diabetes insipidus: a case report. (21717893)
2011
11
Anorexia nervosa and diabetes insipidus in pregnancy. (21073912)
2011
12
Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by (1)H-NMR-based metabonomics. (19923409)
2010
13
Neurobrucellosis associated with syndrome of inappropriate antidiuretic hormone with resultant diabetes insipidus and hypothyroidism. (20702671)
2010
14
Idiopathic central diabetes insipidus: the challenge remains. (20520953)
2010
15
Hypothalamic obesity complicated by adipsic central diabetes insipidus following surgical resection of a craniopharyngioma. (19817945)
2009
16
Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus. (19729439)
2009
17
Compound heterozygous mutation of aquaporin 2 gene in woman patient with congenital nephrogenic diabetes insipidus. (19293543)
2009
18
Diabetes insipidus followed, after 4 years, with dysarthria and mild right-sided hemiparesis--the first clinical signs of Erdheim-Chester disease. Description and depiction of a case with a review of information on the disease]. (20070034)
2009
19
A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. (19729836)
2009
20
Diabetes insipidus following HHV-6 encephalitis after cord blood transplantation in acute myeloid leukemia. (18691755)
2009
21
Diverse vasopressin V2 receptor functionality underlying partial congenital nephrogenic diabetes insipidus. (19812297)
2009
22
Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus. (19170711)
2009
23
Nephrogenic diabetes insipidus with dilatation of bilateral renal pelvis, ureter and bladder. (19037828)
2009
24
Breast cancer with diabetes insipidus. (19112432)
2008
25
Diabetes insipidus with deficient thirst: report of a patient and review of the literature. (18436097)
2008
26
Intracranial aggressive fibromatosis presenting as panhypopituitarism and diabetes insipidus. (16379037)
2005
27
A case of transient diabetes insipidus following cardiopulmonary bypass. (16438283)
2005
28
Perioperative anesthetic management for Cesarean section of a parturient with gestational diabetes insipidus. (16103388)
2005
29
Progressive decline of vasopressin secretion in familial autosomal dominant neurohypophyseal diabetes insipidus presenting a novel mutation in the vasopressin-neurophysin II gene. (14510916)
2003
30
Heteroligomerization of an aquaporin-2 mutant with wild-type aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus. (11929850)
2002
31
Xanthoma disseminatum: a case with hepatic involvement, diabetes insipidus and type IIb hyperlipidaemia. (10233626)
1998
32
Ifosfamide-induced renal Fanconi syndrome with associated nephrogenic diabetes insipidus in an adult patient. (9641191)
1998
33
Hypokalemic nephropathy and nephrogenic diabetes insipidus due to excessive consumption of a soft drink. (9824198)
1998
34
Persistent nephrogenic diabetes insipidus following lithium therapy. (9226773)
1997
35
Congenital nephrogenic diabetes insipidus. (9402099)
1997
36
Optic nerve hypoplasia: absence of posterior pituitary bright signal on magnetic resonance imaging correlates with diabetes insipidus. (8909213)
1996
37
Acute myelogenous leukemia with diabetes insipidus without desmopression administration by anti-leukemic chemotherapy]. (8587172)
1995
38
Novel mutations in the V2 vasopressin receptor gene in two pedigrees with congenital nephrogenic diabetes insipidus. (8045948)
1994
39
Lymphocytic hypophysitis presenting with diabetes insipidus: case report and literature review. (7951558)
1994
40
Congenital nephrogenic diabetes insipidus in an adult. (8507924)
1993
41
Pregnancy-associated subacute hemorrhage into a prolactinoma resulting in diabetes insipidus. (1633915)
1992
42
Central diabetes insipidus due to acute monocytic leukemia: case report and review of the literature. (1569288)
1992
43
Traumatic rupture of the urinary tract in a patient presenting nephrogenic diabetes insipidus associated with hydronephrosis and chronic renal failure: case report and review of the literature. (1424306)
1992
44
Cellular mechanism of lithium-induced nephrogenic diabetes insipidus in rats. (1716061)
1991
45
Hereditary nephrogenic diabetes insipidus type-2. (3149133)
1988
46
Fluid and electrolyte problems associated with diabetes insipidus and syndrome of inappropriate antidiuretic hormone. (3317286)
1987
47
Extensive glomerular immaturity associated with renal tubular acidosis, nephrogenic diabetes insipidus and nephrocalcinosis. (3609098)
1987
48
Treatment of nephrogenic diabetes insipidus with prostaglandin synthesis inhibitors. (3080575)
1986
49
Idiopathic neurogenic diabetes insipidus in a cat. (6639529)
1983
50
Generalized osteosclerosis associated with diabetes insipidus and neurologic symptoms. (13403543)
1957

Genetic Variations for Diabetes Insipidus

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Expression for genes affiliated with Diabetes Insipidus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes Insipidus

Search GEO for disease gene expression data for Diabetes Insipidus.

Pathways for genes affiliated with Diabetes Insipidus

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Diabetes Insipidus

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Diabetes Insipidus according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1forskolin44 49 1112.9POMC
2hgcl24410.8AQP2, MIP, AQP1
3hg2+4410.8MIP, AQP1
4oxytocin28 59 11 2413.8LNPEP, AVPR2, OXT
5mercury4410.8AQP2, AQP1, MIP
6hg2+2810.8AQP1, MIP, AQP6, AQP2
7ipsapirone44 2811.8PRL, POMC, OXT
8hexarelin44 2811.7OXT, POMC, PRL
9ammonium4410.7MIP, AQP1, SLC12A1
10atosiban28 4411.7AVPR2, OXT
11(d(ch2)51,tyr(me)2,arg8)-vasopressin5910.7AVPR2, AVP
12[arg8]-vasopressin5910.7AVP, AVPR2
13flesinoxan4410.7PRL, POMC
14d[leu4,lys8]-vp5910.7AVP, AVPR2
15pge24410.7AQP2, POMC, SLC12A1, LNPEP
16gnrh4410.7MRGPRX1
17furosemide44 49 59 28 11 2415.7SLC12A1, POMC, AQP2
18urea44 11 2412.7MIP, SLC12A1, AQP2, AQP1
19sr 4905959 2811.7AVPR2, AVP
20desmopressin44 59 28 1113.7AVP, AQP2, LNPEP, OXT, POMC, AVPR2
21glycerol44 11 2412.7MIP, POMC, AQP6, AQP1, AQP2
22nacl4410.7MIP, AQP1, AQP2, SLC12A1, CLCNKA, CASR
23vasopressin28 11 2412.7LNPEP, AVPR2
24naloxone44 49 28 1113.7OXT, POMC, PRL
25potassium44 11 2412.7AQP1, SLC12A1, AVPR2, CLCNKA, MIP, CASR
26pcmbs4410.7MIP, AQP1
27chloride4410.6MIP, CLCNKA, CASR, AVP, SLC12A1, AQP1
28creatinine4410.6OXT, AQP2, AQP1, AVP, POMC, CASR
29cysteine4410.6AVPR2, AQP2, AQP1, CASR, AVP, MIP
30sodium44 2411.6AVP, AVPR2, CLCNKA, CASR, SLC12A1, AQP1
31acth4410.6AVP, POMC, AVPR2, LNPEP, OXT, CASR
32acth 1-244410.6POMC, PRL
33nitric oxide44 11 2412.6OXT, AQP1, SLC12A1, AVP, AQP2, MIP
34alanine4410.6AQP1, LNPEP, AVP, AVPR2, POMC, CASR
35dexamethasone44 49 28 1113.6POMC, MIP, PRL, AVP, AQP1, AQP2
36steroid4410.6POMC, OXT, AVP, AQP1, AQP2, PRL
37glutamate4410.6AVPR2, MIP, NPTX2, L1CAM, CASR, AVP
38amastatin4410.6OXT, LNPEP
39opiate4410.6OXT, POMC, PRL
40glucose4410.6AQP2, AQP1, LNPEP, POMC, CASR, PRL
41estradiol benzoate4410.5PRL, OXT
42epinephrine44 11 2412.5POMC, AQP2, PRL, OXT
43arginine4410.5PRL, CASR, POMC, OXT, MIP, AVPR2
44melatonin44 59 28 11 2414.5AVP, OXT, PRL
45calcium44 49 11 2413.4AQP1, CLCNKA, AVPR2, AVP, AQP2, SLC12A1
46progestin4410.4OXT, PRL, POMC
47mifepristone44 59 28 1113.3PRL, OXT, POMC
48progesterone44 59 28 11 2414.3PRL, POMC, OXT, LNPEP, AQP2
49corticosterone44 59 2412.2POMC, PRL, OXT
50asparagine4410.1AVPR2, LNPEP, AQP1

GO Terms for genes affiliated with Diabetes Insipidus

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16Gene Ontology
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Cellular components related to Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:03014110.2AVP, OXT, POMC, PRL
2plasma membraneGO:00588610.1L1CAM, MRGPRX1, MIP, CLCNKA, AVPR2, LNPEP
3integral to plasma membraneGO:0058879.9CASR, MIP, CLCNKA, AVPR2, LNPEP, AQP6

Biological processes related to Diabetes Insipidus according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.7AQP1, AQP2
2multicellular organismal water homeostasisGO:05089110.6AQP1, AVP
3cellular response to mercury ionGO:07128810.6AQP2, AQP1
4excretionGO:00758810.6CLCNKA, AVPR2, AQP6, AQP2
5maternal aggressive behaviorGO:00212510.6OXT, AVP
6hyperosmotic salinity responseGO:04253810.6OXT, AVP
7female pregnancyGO:00756510.6AQP2, LNPEP, OXT, PRL
8water transportGO:00683310.6AQP2, MIP, AVPR2, AVP, AQP6, AQP1
9negative regulation of urine volumeGO:03581110.5OXT, AVPR2
10glycerol transportGO:01579310.5AQP1, AQP2
11cellular response to copper ionGO:07128010.5AQP2, AQP1
12transmembrane transportGO:05508510.5MIP, CLCNKA, AVPR2, AVP, SLC12A1, AQP6
13positive regulation of systemic arterial blood pressureGO:00308410.4AVPR2, AVP
14grooming behaviorGO:00762510.4AVP, OXT
15maternal behaviorGO:04271110.3AVP, OXT
16cell volume homeostasisGO:00688410.1AQP2, AQP1

Molecular functions related to Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water transmembrane transporter activityGO:00537210.4AQP2, AQP1
2water channel activityGO:01525010.3AQP1, AQP6, MIP
3neurohypophyseal hormone activityGO:00518510.3AVP, OXT
4glycerol transmembrane transporter activityGO:01516810.1AQP2, AQP1

Products for genes affiliated with Diabetes Insipidus

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  • Antibodies
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Sources for Diabetes Insipidus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet