MCID: DBT005
MIFTS: 56

Diabetes Insipidus malady

Endocrine category

Summaries for Diabetes Insipidus

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Diabetes insipidus (di) causes frequent urination. you become extremely thirsty, so you drink. then you urinate. this cycle can keep you from sleeping or even make you wet the bed. your body produces lots of urine that is almost all water. di is different from diabetes mellitus (dm), which involves insulin problems and high blood sugar. the symptoms can be similar. however, di is related to how your kidneys handle fluids. it's much less common than dm. urine and blood tests can show which one you have. usually, di is caused by a problem with your pituitary gland or your kidneys. treatment depends on the cause of the problem. medicines can often help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diabetes Insipidus, also known as central diabetes insipidus, is related to nephrogenic diabetes insipidus and neurogenic diabetes insipidus. An important gene associated with Diabetes Insipidus is AVPR2 (arginine vasopressin receptor 2), and among its related pathways are Vasopressin-regulated water reabsorption and Vasopressin-like receptors. The compounds forskolin and hgcl2 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Wikipedia:64 Diabetes insipidus (DI) is a condition characterized by excessive thirst and excretion of large amounts... more...

Aliases & Classifications for Diabetes Insipidus

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

diabetes insipidus 8 10 34
central diabetes insipidus 61


External Ids:

Disease Ontology8 DOID:9409
NCIt40 C43263
MeSH35 D003919
SNOMED-CT57 15771004, 190484000
ICD9CM27 253.5
ICD1025 E23.2

Related Diseases for Diabetes Insipidus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Diabetes Insipidus family:

acquired central diabetes insipidus congenital central diabetes insipidus

Diseases related to Diabetes Insipidus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 249)
idRelated DiseaseScoreTop Affiliating Genes
1nephrogenic diabetes insipidus32.1AVPR2, AQP2
2neurogenic diabetes insipidus31.3AVPR2, AVP, AQP2, OXT, POMC, UBOX5
3panhypopituitarism31.1AVP, POMC, PRL
4pituitary apoplexy30.7PRL, POMC
5sheehan syndrome30.5PRL, POMC
6empty sella syndrome30.4PRL, POMC
7amenorrhea30.4POMC, PRL
8hypercalcemia30.2AVPR2, CASR
9l1 syndrome30.0L1CAM
10polyhydramnios30.0OXT, SLC12A1, AQP1
11pituitary tumors30.0POMC, PRL
12nephrolithiasis30.0CASR
13anorexia nervosa30.0OXT, POMC, PRL
14cushing's syndrome30.0POMC, PRL
15neurohypophyseal diabetes insipidus11.0
16n syndrome10.7
17wolfram syndrome10.6
18lymphocytic hypophysitis10.6
19gestational diabetes insipidus10.6
20acute leukemia10.6
21nephrogenic diabetes insipidus - intracranial calcification10.6
22nephrogenic diabetes insipidus, autosomal10.6
23germinoma10.5
24hydronephrosis10.5
25fanconi syndrome10.5
26renal tubular acidosis10.5
27gestational diabetes10.5
28brain injury10.5
29traumatic brain injury10.5
30congenital central diabetes insipidus10.5
31acute myeloid leukemia10.5
32dipsogenic diabetes insipidus10.4
33acquired central diabetes insipidus10.4
34neurosarcoidosis10.4
35erdheim-chester disease10.4
36holoprosencephaly10.4
37thyroiditis10.4
38septo-optic dysplasia10.4
39hellp syndrome10.3
40nephrocalcinosis10.3
41congenital toxoplasmosis10.3
42toxoplasmosis10.3
43optic nerve hypoplasia10.3
44rickets10.3
45acquired immunodeficiency syndrome10.3
46thyrotoxicosis10.3
47neonatal meningitis10.3
48renal tubular acidosis, distal10.3
49ataxia10.3
50nephritis10.3

Graphical network of the top 20 diseases related to Diabetes Insipidus:



Diseases related to diabetes insipidus

Clinical Features for Diabetes Insipidus

Drugs & Therapeutics for Diabetes Insipidus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Diabetes Insipidus

Drug clinical trials:

Search ClinicalTrials for Diabetes Insipidus

Search NIH Clinical Center for Diabetes Insipidus

Search CenterWatch for Diabetes Insipidus

Genetic Tests for Diabetes Insipidus

Anatomical Context for Diabetes Insipidus

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Diabetes Insipidus:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lung, Bone marrow, Heart, Small intestine, Thyroid, Adrenal gland, Breast, Placenta, Prostate, Myeloid, Monocytes, T cells, B cells, Fetal brain, Hypothalamus, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Pineal, Pituitary

Animal Models for Diabetes Insipidus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Diabetes Insipidus

Sources:
51PubMed
See all sources

Articles related to Diabetes Insipidus:

(show top 50)    (show all 1099)
idTitleAuthorsYear
1
Novel AQP2 mutation causing congenital nephrogenic diabetes insipidus: challenges in management during infancy. (23950570)
2014
2
Inherited secondary nephrogenic diabetes insipidus: concentrating on humans. (23364801)
2013
3
Diabetes insipidus, bone lesions, and new-onset red-brown papules in a 42-year-old man. (23466246)
2013
4
Acute myeloid leukemia with monosomy 20 and diabetes insipidus: a possible novel association. (23121069)
2013
5
Development of central diabetes insipidus following electroconvulsive therapy: results of a prospective pilot study. (23703232)
2013
6
Hereditary nephrogenic diabetes insipidus in Japanese patients: analysis of 78 families and report of 22 new mutations in AVPR2 and AQP2. (23150186)
2013
7
Diabetes insipidus. (23837197)
2013
8
Lamotrigine-induced SIADH in a child with central diabetes insipidus. (21977103)
2011
9
Central diabetes insipidus in children with acute brain insult. (22114999)
2011
10
A case of central diabetes insipidus following probable type A/H1N1 influenza infection. (21828935)
2011
11
Secondary nephrogenic diabetes insipidus as a complication of inherited renal diseases. (20733335)
2010
12
Recurrent pregnancy-induced diabetes insipidus in a woman with hemochromatosis. (20953066)
2010
13
A p1 aneurysm and diabetes insipidus caused by traumatic brain injury. (24148729)
2010
14
Combined central diabetes insipidus and cerebral salt wasting syndrome in children. (19135619)
2009
15
Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus. (19297548)
2009
16
Can a high platelet count be responsible for diabetes insipidus in acute myelogenous leukemia with monosomy 7 and inversion 3 (q21q26)? (19669858)
2009
17
Diabetes insipidus caused by pituitary gland metastasis accompanied by iris metastasis of small cell lung cancer: case presentation and review of the literature. (19112958)
2008
18
Central diabetes insipidus associated with primary focal B cell lymphoma in a dog. (18223271)
2008
19
Autosomal dominant familial neurohypophyseal diabetes insipidus caused by a novel mutation in arginine-vasopressin gene in a Brazilian family. (19169480)
2008
20
Utility of AVP gene testing in familial neurohypophyseal diabetes insipidus. (18494865)
2008
21
Gene symbol: AVP. Disease: Diabetes insipidus, neurohypophyseal. Accession #Hm0560. (17297716)
2006
22
Nephrogenic diabetes insipidus]. (17081961)
2006
23
Nephrogenic diabetes insipidus. (16461963)
2006
24
Loss of calcineurin Aalpha results in altered trafficking of AQP2 and in nephrogenic diabetes insipidus. (16735444)
2006
25
Idiopathic central diabetes insipidus in children and young adults is commonly associated with vasopressin-cell antibodies and markers of autoimmunity. (16984239)
2006
26
Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus. (16014574)
2005
27
Functional rescue of the nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutants G185C and R202C by a second site suppressor mutation. (11116139)
2001
28
Ovulation induction with pulsatile gonadotropin-releasing hormone (GnRH) or gonadotropins in a case of hypothalamic amenorrhea and diabetes insipidus. (11826765)
2001
29
A case of SjAPgren's syndrome complicated by nephrogenic diabetes insipidus and renal tubular acidosis. (24383598)
2000
30
A case of lymphocytic infundibuloneurohypophysitis showing diabetes insipidus followed by anterior hypopituitarism associated with thrombasthenia. (11036872)
2000
31
Identification of two distinct mutations at the same nucleotide position, concomitantly with a novel polymorphism in the vasopressin- neurophysin II gene (AVP-NP II) in two Dutch families with familial neurohypophyseal diabetes insipidus. (11017955)
2000
32
Study on the antidiuretic efficacy and mechanism of indapamide in central diabetes insipidus]. (12016800)
1999
33
Vasopressin processing defects in the Brattleboro rat: implications for hereditary central diabetes insipidus in humans? (9756087)
1998
34
Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus. (8882880)
1996
35
Nephrogenic diabetes insipidus secondary to lithium therapy in the postoperative patient: a case report. (7978676)
1994
36
A Null mutation in the vasopressin V2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus in the Hopewell kindred. (8401502)
1993
37
Familial neurohypophyseal diabetes insipidus associated with a signal peptide mutation. (8370682)
1993
38
Evidence for intact V1-vasopressin receptors in congenital nephrogenic diabetes insipidus. (1396896)
1992
39
Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD syndrome). A clinical study in two Sudanese families. (1872184)
1991
40
Hereditary nephrogenic diabetes insipidus. (2063710)
1991
41
A family case of nephrogenic diabetes insipidus. (2097813)
1990
42
Three-point linkage analysis using multiple DNA polymorphic markers in families with X-linked nephrogenic diabetes insipidus. (2714800)
1989
43
Hypernatraemia due to a reset osmostat for vasopressin release and thirst, complicated by nephrogenic diabetes insipidus. (3451225)
1987
44
Nephrogenic diabetes insipidus in a female infant with hydrocephalus. (3766477)
1986
45
Vasopressin and ethanol preference. II. Altered preference in two strains of diabetes insipidus rats and nephrogenic diabetes insipidus mice. (4070023)
1985
46
Congenital nephrogenic diabetes insipidus with bilateral hydronephrosis: indomethacin in treatment of nephrogenic diabetes insipidus. (7314648)
1980
47
Renal prostaglandin E2 in nephrogenic diabetes insipidus: effects of inhibition of prostaglandin synthesis by indomethacin. (6251193)
1980
48
Nephrogenic diabetes insipidus in transplacental lithium intoxication. (423043)
1979
49
Persistent nephrogenic diabetes insipidus after lithium carbonate. (848808)
1977
50
Pinealomatous teratoma with varied interesting clinical symptoms 1) diabetes insipidus, 2) panhypopituitarism, 3) hypernatremia and hyperchloremia, 4) pseudo-Argyll-Robertson pupil, 5) Parslnaud's syndrome; a case report. (13574271)
1958

Genetic Variations for Diabetes Insipidus

Expression for genes affiliated with Diabetes Insipidus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetes Insipidus

Search GEO for disease gene expression data for Diabetes Insipidus.

Pathways for genes affiliated with Diabetes Insipidus

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Diabetes Insipidus

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Diabetes Insipidus according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1forskolin45 50 1112.9POMC
2hgcl24510.8AQP2, AQP1, MIP
3hg2+4510.8AQP1, MIP
4oxytocin29 60 11 2413.8OXT, AVPR2, LNPEP
5mercury4510.8MIP, AQP1, AQP2
6hg2+2910.8MIP, AQP6, AQP1, AQP2
7ipsapirone45 2911.8OXT, POMC, PRL
8hexarelin45 2911.7OXT, POMC, PRL
9ammonium4510.7AQP1, SLC12A1, MIP
10atosiban29 4511.7OXT, AVPR2
11d[leu4,lys8]-vp6010.7AVPR2, AVP
12(d(ch2)51,tyr(me)2,arg8)-vasopressin6010.7AVPR2, AVP
13flesinoxan4510.7PRL, POMC
14[arg8]-vasopressin6010.7AVPR2, AVP
15pge24510.7POMC, LNPEP, SLC12A1, AQP2
16gnrh4510.7MRGPRX1
17furosemide45 50 60 29 11 2415.7AQP2, SLC12A1, POMC
18urea45 11 2412.7MIP, SLC12A1, AQP1, AQP2
19sr 4905960 2911.7AVPR2, AVP
20desmopressin45 60 29 1113.7AQP2, POMC, OXT, AVPR2, AVP, LNPEP
21glycerol45 11 2412.7POMC, MIP, AQP6, AQP1, AQP2
22nacl4510.7CASR, MIP, CLCNKA, SLC12A1, AQP1, AQP2
23pcmbs4510.7AQP1, MIP
24naloxone45 50 29 1113.7OXT, POMC, PRL
25potassium45 11 2412.7CASR, MIP, CLCNKA, AVPR2, SLC12A1, AQP1
26vasopressin29 11 2412.7LNPEP, AVPR2
27chloride4510.6CASR, MIP, CLCNKA, AVPR2, AVP, SLC12A1
28creatinine4510.6CASR, POMC, OXT, AVP, AQP1, AQP2
29cysteine4510.6CASR, MIP, AVPR2, AVP, AQP1, AQP2
30sodium45 2411.6CASR, MIP, CLCNKA, AVPR2, AVP, SLC12A1
31acth4510.6CASR, PRL, POMC, OXT, AVPR2, AVP
32nitric oxide45 11 2412.6CASR, OXT, MIP, AVP, SLC12A1, AQP1
33alanine4510.6CASR, POMC, AVPR2, AVP, LNPEP, AQP1
34dexamethasone45 50 29 1113.6PRL, POMC, MIP, AVP, AQP1, AQP2
35amastatin4510.6LNPEP, OXT
36steroid4510.6PRL, POMC, OXT, AVP, AQP1, AQP2
37acth 1-244510.6POMC, PRL
38glutamate4510.6CASR, L1CAM, NPTX2, OXT, MIP, AVPR2
39opiate4510.6PRL, POMC, OXT
40glucose4510.6CASR, PRL, POMC, MIP, AVP, LNPEP
41estradiol benzoate4510.5OXT, PRL
42epinephrine45 11 2412.5PRL, POMC, OXT, AQP2
43arginine4510.5CASR, ARHGAP4, PRL, POMC, OXT, MIP
44melatonin45 60 29 11 2414.5PRL, OXT, AVP
45calcium45 50 11 2413.4OXT, WFS1, NPTX2, MRGPRX1, CASR, MIP
46progestin4510.4OXT, POMC, PRL
47mifepristone45 60 29 1113.3OXT, POMC, PRL
48progesterone45 60 29 11 2414.3PRL, POMC, OXT, LNPEP, AQP2
49corticosterone45 60 2412.2PRL, POMC, OXT
50asparagine4510.1AVPR2, LNPEP, AQP1

GO Terms for genes affiliated with Diabetes Insipidus

Sources:
16Gene Ontology
See all sources

Cellular components related to Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:03014110.2AVP, OXT, POMC, PRL
2plasma membraneGO:00588610.1L1CAM, MRGPRX1, MIP, CLCNKA, AVPR2, LNPEP
3integral to plasma membraneGO:0058879.9CASR, MIP, CLCNKA, AVPR2, LNPEP, AQP6

Biological processes related to Diabetes Insipidus according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.7AQP1, AQP2
2multicellular organismal water homeostasisGO:05089110.6AQP1, AVP
3cellular response to mercury ionGO:07128810.6AQP2, AQP1
4excretionGO:00758810.6CLCNKA, AVPR2, AQP6, AQP2
5maternal aggressive behaviorGO:00212510.6OXT, AVP
6hyperosmotic salinity responseGO:04253810.6OXT, AVP
7female pregnancyGO:00756510.6AQP2, LNPEP, OXT, PRL
8water transportGO:00683310.6AQP2, MIP, AVPR2, AVP, AQP6, AQP1
9negative regulation of urine volumeGO:03581110.5OXT, AVPR2
10glycerol transportGO:01579310.5AQP1, AQP2
11cellular response to copper ionGO:07128010.5AQP2, AQP1
12transmembrane transportGO:05508510.5MIP, CLCNKA, AVPR2, AVP, SLC12A1, AQP6
13positive regulation of systemic arterial blood pressureGO:00308410.4AVPR2, AVP
14grooming behaviorGO:00762510.4AVP, OXT
15maternal behaviorGO:04271110.3AVP, OXT
16cell volume homeostasisGO:00688410.1AQP2, AQP1

Molecular functions related to Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water transmembrane transporter activityGO:00537210.4AQP2, AQP1
2water channel activityGO:01525010.3AQP1, AQP6, MIP
3neurohypophyseal hormone activityGO:00518510.3AVP, OXT
4glycerol transmembrane transporter activityGO:01516810.1AQP2, AQP1

Products for genes affiliated with Diabetes Insipidus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetes Insipidus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet