MCID: DBT005
MIFTS: 57

Diabetes Insipidus malady

Endocrine diseases, Nephrological diseases, Rare diseases, Neuronal diseases categories

Summaries for Diabetes Insipidus

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35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Diabetes insipidus (di) causes frequent urination. you become extremely thirsty, so you drink. then you urinate. this cycle can keep you from sleeping or even make you wet the bed. your body produces lots of urine that is almost all water. di is different from diabetes mellitus (dm), which involves insulin problems and high blood sugar. the symptoms can be similar. however, di is related to how your kidneys handle fluids. it's much less common than dm. urine and blood tests can show which one you have. usually, di is caused by a problem with your pituitary gland or your kidneys. treatment depends on the cause of the problem. medicines can often help. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diabetes Insipidus, also known as central diabetes insipidus, is related to nephrogenic diabetes insipidus and neurogenic diabetes insipidus. An important gene associated with Diabetes Insipidus is AVPR2 (arginine vasopressin receptor 2), and among its related pathways are Vasopressin-regulated water reabsorption and Diuretics Pathway, Pharmacodynamics. The compounds d[leu4,lys8]-vp and (d(ch2)51,tyr(me)2,arg8)-vasopressin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, kidney and testes, and related mouse phenotypes are renal/urinary system and integument.

Wikipedia:66 Diabetes insipidus (DI) is a condition characterized by excessive thirst and excretion of large amounts... more...

Aliases & Classifications for Diabetes Insipidus

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9Disease Ontology, 11DISEASES, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt, 26ICD10
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Classifications:



Aliases & Descriptions:

diabetes insipidus 9 11 35
central diabetes insipidus 63


External Ids:

Disease Ontology9 DOID:9409
ICD9CM28 253.5
MeSH36 D003919
SNOMED-CT59 15771004, 190484000
NCIt41 C43263
ICD1026 E23.2

Related Diseases for Diabetes Insipidus

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Diabetes Insipidus family:

Acquired Central Diabetes Insipidus Congenital Central Diabetes Insipidus

Diseases related to Diabetes Insipidus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 274)
idRelated DiseaseScoreTop Affiliating Genes
1nephrogenic diabetes insipidus32.2AQP2, AVPR2
2neurogenic diabetes insipidus31.5AQP2, AVPR2, AVP
3hypopituitarism31.1AQP2, AVP
4syndrome of inappropriate antidiuretic hormone30.7AVPR2, AVP, AQP2
5hydrocephalus30.3AQP1, L1CAM
6nephrogenic syndrome of inappropriate antidiuresis30.2AVPR2
7l1 syndrome30.2L1CAM
8polyhydramnios30.0AQP1, SLC12A1
9cystic fibrosis30.0AQP1, MIP, AQP2
10neurohypophyseal diabetes insipidus11.0
11panhypopituitarism10.7
12diabetes mellitus10.7
13histiocytosis10.7
14langerhans-cell histiocytosis10.7
15leukemia10.7
16optic atrophy10.7
17gestational diabetes insipidus10.6
18lymphocytic hypophysitis10.6
19wolfram syndrome10.6
20germinoma10.5
21renal tubular acidosis10.5
22neuronitis10.5
23gestational diabetes10.5
24cerebritis10.5
25myeloid leukemia10.5
26brain injury10.5
27traumatic brain injury10.5
28pituitary apoplexy10.5
29hydronephrosis10.5
30acute myeloid leukemia10.5
31fanconi syndrome10.5
32encephalitis10.5
33thyroiditis10.5
34dipsogenic diabetes insipidus10.5
35acquired central diabetes insipidus10.5
36meningitis10.4
37neurosarcoidosis10.4
38holoprosencephaly10.4
39erdheim-chester disease10.4
40craniopharyngioma10.4
41hypothyroidism10.4
42lung cancer10.4
43sarcoidosis10.4
44septo-optic dysplasia10.4
45congenital central diabetes insipidus10.4
46nephrocalcinosis10.3
47wegener's granulomatosis10.3
48empty sella syndrome10.3
49congenital toxoplasmosis10.3
50hellp syndrome10.3

Graphical network of the top 20 diseases related to Diabetes Insipidus:



Diseases related to diabetes insipidus

Symptoms for Diabetes Insipidus

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Drugs & Therapeutics for Diabetes Insipidus

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Diabetes Insipidus

Drug clinical trials:

Search ClinicalTrials for Diabetes Insipidus

Search NIH Clinical Center for Diabetes Insipidus

Search CenterWatch for Diabetes Insipidus

Genetic Tests for Diabetes Insipidus

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Anatomical Context for Diabetes Insipidus

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34MalaCards
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MalaCards organs/tissues related to Diabetes Insipidus:

34
Pituitary, Kidney, Testes, Brain, Myeloid, Thyroid, Liver, Lung, Bone, Pineal, Hypothalamus, Breast, Prostate, B cells, T cells, Heart, Monocytes, Placenta, Bone marrow, Eye, Skin

Animal Models for Diabetes Insipidus or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Diabetes Insipidus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.7SLC12A1, AQP1, AQP2, CLCNKA, AVP, AVPR2
2MP:00107717.6AVPR2, L1CAM, AQP2, WFS1, SLC12A1
3MP:00053787.4SLC12A1, WFS1, AQP1, AQP2, L1CAM, AVPR2
4MP:00053767.2AVPR2, AVP, CLCNKA, AQP2, AQP1, WFS1
5MP:00053867.1AVPR2, AVP, L1CAM, AQP2, AQP1, WFS1
6MP:00107687.0AVPR2, AVP, L1CAM, AQP2, AQP1, WFS1

Publications for Diabetes Insipidus

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53PubMed
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Articles related to Diabetes Insipidus:

(show top 50)    (show all 1084)
idTitleAuthorsYear
1
Pulmonary thrombosis associated with antidiuretic hormone replacement therapy due to secondary diabetes insipidus after traumatic brain injury: A case report. (23131855)
2013
2
Pheochromocytoma presenting as diabetes insipidus. (24382904)
2013
3
Central diabetes insipidus in pediatric severe traumatic brain injury. (23314181)
2013
4
Incidence, predictors and early post-operative course of diabetes insipidus in paediatric craniopharygioma: a comparison with adults. (23386174)
2013
5
Nephrogenic diabetes insipidus with intracranial calcification in a child with thalassemia minor. (24053747)
2013
6
Hypernatremia-associated coma caused by glucocorticoid replacement for adrenal crisis in an unrecognized central diabetes insipidus patient. (24018158)
2013
7
Hypopituitarism and central diabetes insipidus: perioperative diagnosis and management. (23040752)
2012
8
Remarkable cystic expansion of microprolactinoma causing diabetes insipidus during pregnancy. (22593591)
2012
9
Metastatic prostate adenocarcinoma presenting central diabetes insipidus. (22474455)
2012
10
Panhypopituitarism and diabetes insipidus in a patient with primary central nervous system lymphoma. (22563813)
2012
11
Central diabetes insipidus and hypothalamic type of hypopituitarism associated with atypical location of Rathke's cleft cyst. (22246489)
2012
12
Novel compound aquaporin 2 mutations in nephrogenic diabetes insipidus. (22249485)
2012
13
Management of diabetes insipidus in children. (22029022)
2011
14
Central diabetes insipidus in association with neonatal brain abscess. (20480721)
2010
15
Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by (1)H-NMR-based metabonomics. (19923409)
2010
16
Septo-optic dysplasia plus: a patient with diabetes insipidus. (20682211)
2010
17
Hypothalamic obesity complicated by adipsic central diabetes insipidus following surgical resection of a craniopharyngioma. (19817945)
2009
18
Permanent central diabetes insipidus after mild traumatic brain injury. (19891534)
2009
19
Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus. (19367330)
2009
20
Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus. (19729439)
2009
21
Central diabetes insipidus misdiagnosed as acute gastroenteritis in a pediatric patient. (18826743)
2008
22
Diabetes insipidus caused by pituitary gland metastasis accompanied by iris metastasis of small cell lung cancer: case presentation and review of the literature. (19112958)
2008
23
Identification of two novel aquaporin-2 mutations in a Thai girl with congenital nephrogenic diabetes insipidus. (18473191)
2008
24
Microvascular diabetes complications in Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness [DIDMOAD]): an age- and duration-matched comparison with common type 1 diabetes. (17536072)
2007
25
Adipsic diabetes insipidus following pituitary surgery for a macroprolactinoma. (16703410)
2006
26
Gene symbol: AVP. Disease: Diabetes insipidus, neurohypophyseal. Accession #Hm0560. (17297716)
2006
27
Wegener's granulomatosis presenting as diabetes insipidus. (17115352)
2006
28
Minor disturbances in central nervous system function in familial neurohypophysial diabetes insipidus. (16125866)
2006
29
The value of urine specific gravity in detecting diabetes insipidus in a patient with uncontrolled diabetes mellitus: urine specific gravity in differential diagnosis. (17026722)
2006
30
Serial T1-weighted magnetic resonance imaging changes in a patient with central diabetes insipidus, possibly due to lymphocytic infundibuloneurohypophysitis. (16322406)
2005
31
Diabetes insipidus, secondary hypoadrenalism and hypothyroidism after traumatic brain injury: clinical implications. (16508710)
2005
32
Methotrexate-induced nephrogenic diabetes insipidus: first case report. (11886979)
2002
33
Water intake and 24-hour blood pressure monitoring in a patient with nephrogenic diabetes insipidus caused by a novel mutation of the vasopressin V2R gene. (11868598)
2002
34
Lithium-induced nephrogenic diabetes insipidus in older people. (11509315)
2001
35
Lithium-induced nephrogenic diabetes insipidus. (11246113)
2001
36
Misfolded vasopressin V2 receptors caused by extracellular point mutations entail congenital nephrogenic diabetes insipidus. (11026555)
2000
37
Familial neurohypophyseal diabetes insipidus associated with a novel mutation in the vasopressin-neurophysin II gene. (10677561)
2000
38
Evolution of childhood central diabetes insipidus into panhypopituitarism with a large hypothalamic mass: is 'lymphocytic infundibuloneurohypophysitis' in children a different entity? (9916870)
1998
39
Identification of mutations of the arginine vasopressin-neurophysin II gene in two kindreds with familial central diabetes insipidus. (9467595)
1998
40
Autosomal dominant neurohypophyseal diabetes insipidus associated with a missense mutation encoding Gly23-->Val in neurophysin II. (9360520)
1997
41
Congenital microgastria, growth hormone deficiency and diabetes insipidus. (9007489)
1997
42
Heterologous expression of human vasopressin-neurophysin precursors in a pituitary cell line: defective transport of a mutant protein from patients with familial diabetes insipidus. (8945633)
1996
43
Nephrogenic diabetes insipidus secondary to lithium therapy in the postoperative patient: a case report. (7978676)
1994
44
Optic atrophy, diabetes mellitus and diabetes insipidus. (3723871)
1986
45
Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus. (3970081)
1985
46
Nephrogenic diabetes insipidus associated with Dyazide (triamterene-hydrochlorothiazide). (6794799)
1981
47
Post-obstructive diuresis in nephrogenic diabetes insipidus associated with bladder neck obstruction. (423345)
1979
48
Primary empty sella syndrome with panhypopituitarism, diabetes insipidus, and visual field defects. (707005)
1978
49
Nephrogenic diabetes insipidus and Werdnig-Hoffmann disease in a child: an unusual association. (671487)
1978
50
Diabetes insipidus and panhypopituitarism after pituitary infarction in a case of acromegaly. (890301)
1977

Variations for Diabetes Insipidus

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Expression for genes affiliated with Diabetes Insipidus

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes Insipidus

Search GEO for disease gene expression data for Diabetes Insipidus.

Pathways for genes affiliated with Diabetes Insipidus

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Sources:
51PathCards, 31KEGG, 52PharmGKB, 56Reactome, 61Thomson Reuters
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Pathways related to Diabetes Insipidus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4AVPR2, AQP2, AVP
29.2CLCNKA, SLC12A1
3
Show member pathways
8.4AVP, AQP2, AQP1, MIP, AVPR2
4
Show member pathways
7.1SLC12A1, AVPR2, AVP, CLCNKA, AQP2, AQP1

Compounds for genes affiliated with Diabetes Insipidus

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Sources:
62Tocris Bioscience, 30IUPHAR, 46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Diabetes Insipidus according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1d[leu4,lys8]-vp6210.2AVPR2, AVP
2(d(ch2)51,tyr(me)2,arg8)-vasopressin6210.2AVPR2, AVP
3[arg8]-vasopressin6210.2AVPR2, AVP
4sr 4905962 3011.2AVP, AVPR2
5vas-a4610.0AQP1, AVPR2
6abscisic acid469.9AVP, MIP
7desmopressin46 62 30 1212.8AVPR2, AVP, AQP2
8hg2+469.8MIP, AQP1
9dids46 3010.8AQP1, CLCNKA
10pcmbs469.8MIP, AQP1
11tetraethylammonium46 30 1211.6AQP1, MIP
12histidine469.5AQP1, AVP, AVPR2
13furosemide46 62 30 52 25 1214.5SLC12A1, AQP2
14bicarbonate469.5MIP, AQP1
15hgcl2469.5AQP2, AQP1, MIP
16hg2+309.5MIP, AQP1, AQP2
17mercury469.5MIP, AQP1, AQP2
18glycerol46 25 1211.4AQP2, AQP1, MIP
19creatinine469.3AQP1, AQP2, AVP
20asparagine469.3AQP1, AVPR2
21silver469.3MIP, AQP1
22cyclic amp46 2510.3AVPR2, AQP2, MIP
23hydrogen46 2510.2AQP2, AQP1, MIP
24alanine469.2AVPR2, AVP, AQP2, AQP1
25dexamethasone46 52 30 1212.0MIP, AQP1, AQP2, AVP
26ammonium469.0SLC12A1, MIP, AQP1
27glucose469.0AVP, AQP2, AQP1, MIP
28glutamate468.9MIP, L1CAM, AVP, AVPR2
29forskolin46 52 1210.9SLC12A1, AQP1, AQP2
30magnesium46 25 1210.8SLC12A1, AQP2, CLCNKA
31arginine468.8AVPR2, AVP, AQP2, AQP1, MIP
32cysteine468.7AVPR2, AVP, AQP2, AQP1, MIP
33urea46 25 1210.6AQP2, AQP1, MIP, SLC12A1
34nitric oxide46 25 1210.3AVP, AQP2, AQP1, MIP, SLC12A1
35nacl468.2CLCNKA, AQP2, AQP1, MIP, SLC12A1
36potassium46 25 129.9AVPR2, CLCNKA, AQP2, AQP1, MIP, SLC12A1
37chloride467.5SLC12A1, AVPR2, AVP, CLCNKA, AQP2, AQP1
38sodium46 258.5AVPR2, AVP, CLCNKA, AQP2, AQP1, MIP
39calcium46 52 25 1210.1AVPR2, AVP, CLCNKA, AQP2, AQP1, MIP

GO Terms for genes affiliated with Diabetes Insipidus

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17Gene Ontology
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Cellular components related to Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7MIP, AQP1, CLCNKA, AVPR2
2plasma membraneGO:0058866.5SLC12A1, AVPR2, L1CAM, CLCNKA, AQP2, AQP1

Biological processes related to Diabetes Insipidus according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of systemic arterial blood pressureGO:0030849.9AVPR2, AVP
2renal water transportGO:0030979.8AQP1, AQP2
3cellular response to mercury ionGO:0712889.8AQP2, AQP1
4glycerol transportGO:0157939.8AQP1, AQP2
5cellular response to copper ionGO:0712809.8AQP1, AQP2
6multicellular organismal water homeostasisGO:0508919.8AVP, AQP1
7positive regulation of calcium ion transportGO:0519289.7WFS1, AQP2
8cell volume homeostasisGO:0068849.6AQP2, AQP1
9positive regulation of protein ubiquitinationGO:0313989.6WFS1, AVPR2
10excretionGO:0075889.6AQP2, CLCNKA, AVPR2
11negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0431549.3AQP1, AVP
12potassium ion transportGO:0068139.1SLC12A1, AQP1
13water transportGO:0068338.7MIP, AQP1, AQP2, AVP, AVPR2
14transmembrane transportGO:0550857.4AVPR2, AVP, CLCNKA, AQP2, AQP1, MIP

Molecular functions related to Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycerol transmembrane transporter activityGO:0151689.5AQP1, AQP2
2water channel activityGO:0152509.4MIP, AQP1
3water transmembrane transporter activityGO:0053729.3AQP1, AQP2

Products for genes affiliated with Diabetes Insipidus

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  • Antibodies
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Sources for Diabetes Insipidus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet