MCID: DBT088
MIFTS: 60

Diabetes Insipidus, Nephrogenic malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases

Aliases & Classifications for Diabetes Insipidus, Nephrogenic

About this section
Sources:
49OMIM, 11diseasecard, 23Genetics Home Reference, 36MeSH, 10Disease Ontology, 21GeneReviews, 45NIH Rare Diseases, 22GeneTests, 12DISEASES, 51Orphanet, 65UMLS, 47Novoseek, 24GTR, 67UniProtKB/Swiss-Prot, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet, 34MedGen, 61The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Diabetes Insipidus, Nephrogenic:

Name: Diabetes Insipidus, Nephrogenic 49 11 23 36
Nephrogenic Diabetes Insipidus 10 21 45 22 23 12 51 65
Vasopressin-Resistant Diabetes Insipidus 10 45 23
Diabetes Insipidus Nephrogenic 45 47 24
Diabetes Insipidus, Nephrogenic, Autosomal 67 24
Congenital Nephrogenic Diabetes Insipidus 23 65
Diabetes Insipidus, Nephrogenic, X-Linked 67 24
Diabetes Insipidus Nephrogenic Type 1 45 67
Adh-Resistant Diabetes Insipidus 23 65
Ndi 22 23
Nephrogenic Diabetes Insipidus, Autosomal 22
 
Nephrogenic Diabetes Insipidus, X-Linked 22
Diabetes Insipidus Nephrogenic X-Linked 45
Nephrogenic Diabetes Insipidus, Type I 65
Diabetes Insipidus Nephrogenic Type 2 67
Adh Resistant Diabetes Insipidus 45
Diabetes Insipidus Renalis 23
Ndi, Autosomal 22
Ndi, X-Linked 22
Xndi 67
Andi 67

Characteristics:

Orphanet epidemiological data:

51
nephrogenic diabetes insipidus:
Inheritance: Autosomal dominant,Autosomal recessive,X-linked recessive; Prevalence: 1-9/1000000 (Europe); Age of onset: Infancy,Neonatal

HPO:

61


Classifications:

Orphanet: 51 
Rare renal diseases


External Ids:

Disease Ontology10 DOID:12387
ICD1027 N25.1
ICD9CM29 588.1
MeSH36 D018500
NCIt42 C84919
Orphanet51 223
UMLS via Orphanet66 C0162283
ICD10 via Orphanet28 N25.1
MESH via Orphanet37 D018500
UMLS65 C0162283, C0677501, C3542500 C1563705, more

Summaries for Diabetes Insipidus, Nephrogenic

About this section
NIH Rare Diseases:45 Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. nephrogenic diabetes insipidus occurs when the kidney tubules, which allow water to be removed from the body or reabsorbed, do not respond to a chemical in the body called antidiuretic hormone (adh) or vasopressin. adh normally tells the kidneys to make the urine more concentrated. as a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine.nephrogenic diabetes insipidus can be either acquired or hereditary. the acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. the hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life. last updated: 7/31/2011

MalaCards based summary: Diabetes Insipidus, Nephrogenic, also known as nephrogenic diabetes insipidus, is related to diabetes insipidus nephrogenic mental retardation and intracerebral calcification and nephrogenic diabetes insipidus-intracranial calcification syndrome, and has symptoms including feeding difficulties in infancy, short stature and hypernatremia. An important gene associated with Diabetes Insipidus, Nephrogenic is AVPR2 (Arginine Vasopressin Receptor 2), and among its related pathways are Diuretics Pathway, Pharmacodynamics and Vasopressin-regulated water reabsorption. Affiliated tissues include heart, kidney and liver, and related mouse phenotypes are behavior/neurological and mortality/aging.

Disease Ontology:10 An impaired renal function disease characterized by a complete or partial resistance of the kidneys to vasopressin (ADH).

Genetics Home Reference:23 Nephrogenic diabetes insipidus is a disorder of water balance. The body normally balances fluid intake with the excretion of fluid in urine. However, people with nephrogenic diabetes insipidus produce too much urine (polyuria), which causes them to be excessively thirsty (polydipsia). Affected individuals can quickly become dehydrated if they do not drink enough water, especially in hot weather or when they are sick.

OMIM:49 Nephrogenic diabetes insipidus is caused by the inability of the renal collecting ducts to absorb water in response to... (125800) more...

UniProtKB/Swiss-Prot:67 Diabetes insipidus, nephrogenic, autosomal: A disorder caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. Characterized by excessive water drinking (polydipsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive. Diabetes insipidus, nephrogenic, X-linked: A disorder caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. Characterized by excessive water drinking (polydipsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia.

Wikipedia:68 Nephrogenic diabetes insipidus is a form of diabetes insipidus primarily due to pathology of the kidney.... more...

Description from OMIM:49 304800

GeneReviews summary for NBK1177

Related Diseases for Diabetes Insipidus, Nephrogenic

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Diseases related to Diabetes Insipidus, Nephrogenic via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus nephrogenic mental retardation and intracerebral calcification12.2
2nephrogenic diabetes insipidus-intracranial calcification syndrome12.2
3diabetes insipidus, neurohypophyseal11.3
4diabetes insipidus10.7
5left-right axis malformations10.6AQP2, AVP
6corpus callosum, partial agenesis of10.6AVPR2, L1CAM
7idiopathic hypersomnia10.6AQP1, AQP2
8inner ear disease10.6AQP1, AVP
9mental retardation, x-linked, syndromic 3210.5AVP, AVPR2, FGF23
10syngap1-related non-syndromic intellectual disability10.5AQP2, AVP, AVPR2
11gastric leiomyosarcoma10.5AQP1, AQP3
12meniere's disease10.4AQP1, AQP2, AVP
13dysgraphia10.4AQP1, AQP2, AVP
14specific bursitis often of occupational origin10.4AQP1, AQP3
15subpulmonary stenosis10.4AQP1, AQP4
16b-cell lymphomas10.4CLCNKA, SLC12A1
17dystonia/parkinsonism, hypermanganesemia, polycythemia, and chronic liver disease10.3AQP1, AQP4
18lateral sclerosis10.3AQP1, SLC12A1
19immature cataract10.3AQP1, AQP4
20rheumatoid lung disease10.2AQP1, AQP3, SLC12A1
21malignant histiocytic disease10.2AQP1, C2
22acral lentiginous melanoma10.2AQP1, AQP4, AVP
23vasomotor rhinitis10.1AQP1, AQP4, MIP
24autonomic nervous system disease10.1AQP1, AQP4, AVP
25leukodystrophy10.1ATP6V0A4, FGF23
26neutropenia10.1AQP1, AQP4
27chromophobe adenocarcinoma10.1ATP6V0A4, SLC12A1
28psychologic dyspareunia10.0AQP2, SLC12A1
29histiocytosis10.0AQP2, AVP, AVPR2, C2
30african tick-bite fever9.9ATP6V0A4, FGF23
31ossifying fibroma9.9AQP2, ATP6V0A4, AVP, FGF23
32retinitis pigmentosa 469.6AQP2, AVP, AVPR2, C2, LNPEP
33allergic asthma9.5AQP2, ARHGAP4, AVP, AVPR2, CLCNKA, SLC12A1
34gonadal dysgenesis9.3AQP1, AQP3, AQP4, AQP7
35diabetic angiopathy9.3AQP1, AQP2, AQP3, AVP, AVPR2, CLCNKA
36lingual-facial-buccal dyskinesia9.2AQP1, AQP2, AQP4, AQP7, MIP
37palmoplantar keratoderma, bothnian type5.3AQP1, AQP2, AQP3, AQP4, AQP7, ARHGAP4

Comorbidity relations with Diabetes Insipidus, Nephrogenic via Phenotypic Disease Network (PDN):


Bipolar DisorderAcute Cystitis
Diabetes Insipidus

Graphical network of the top 20 diseases related to Diabetes Insipidus, Nephrogenic:



Diseases related to diabetes insipidus, nephrogenic

Symptoms for Diabetes Insipidus, Nephrogenic

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Symptoms by clinical synopsis from OMIM:

125800

Clinical features from OMIM:

125800,304800

HPO human phenotypes related to Diabetes Insipidus, Nephrogenic:

(show all 16)
id Description Frequency HPO Source Accession
1 feeding difficulties in infancy HP:0008872
2 short stature HP:0004322
3 hypernatremia HP:0003228
4 constipation HP:0002019
5 vomiting HP:0002013
6 hypertonic dehydration HP:0001986
7 polydipsia HP:0001959
8 unexplained fevers HP:0001955
9 failure to thrive HP:0001508
10 seizures HP:0001250
11 intellectual disability HP:0001249
12 diabetes insipidus HP:0000873
13 irritability HP:0000737
14 polyuria HP:0000103
15 megacystis HP:0000021
16 nephrogenic diabetes insipidus HP:0009806

UMLS symptoms related to Diabetes Insipidus, Nephrogenic:


polydipsia, vomiting, seizures, polyuria, constipation

Drugs & Therapeutics for Diabetes Insipidus, Nephrogenic

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Drugs for Diabetes Insipidus, Nephrogenic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 71)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
FurosemideapprovedPhase 4, Phase 3, Phase 2, Phase 117154-31-93440
Synonyms:
2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid
4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid
4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid
4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
41733-55-5 (mono-hydrochloride salt)
5-18-09-00555 (Beilstein Handbook Reference)
54-31-9
AB00052001
AC-11067
AC1L1FXW
AC1Q557O
AKOS000266625
ARONIS24304
Acetic acid potassium salt
Aisemide
Aldalix
Aldic
Aluzine
Anfuramaide
Apo-Frusemide
Apo-Furosemide
Aquarid
Aquasin
Arasemide
BIDD:GT0139
BPBio1_000443
BRD-K78010432-001-05-8
BRN 0840915
BSPBio_000401
BSPBio_002054
Beronald
Bio-0044
Bioretic
Bristab
Bristurin
C12H11ClN2O5S
CAS-54-31-9
CCRIS 1951
CHEBI:47426
CHEMBL35
CID3440
CPD000058202
Cetasix
Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure
Chlor-N-(2-furylmethyl)-5-sulfamylanthranilsaeure [German]
D00331
D005665
DB00695
DB07799
Depix
Desal
Desdemin
Di-Ademil
Dihydroflumethiazide
Dirine
Disal
Discoid
Disemide
Diucardin
Diumide-K
Diural
Diurapid
Diuretic Salt
Diuretic salt
Diurin
Diurolasa
Diusemide
Diusil
Diuzol
DivK1c_000575
Dranex
Dryptal
Durafurid
EINECS 200-203-6
Edemid
Edenol
Eliur
Elodrine
Endural
Errolon
Eutensin
F0182
F4381_SIGMA
FUN
FUROSEMIDE USP
Farsix
Finuret
Fluidrol
Fluss
Franyl
Frumex
Frumide
Frumil
Frusedan
Frusema
Frusemid
Frusemide
Frusemin
Frusenex
Frusetic
Frusid
Fu sid
Fulsix
Fuluvamide
Fuluvamine
Furanthril
Furanthryl
Furantral
Furantril
Furanturil
Furesis
Furetic
Furex
Furfan
Furix
Furmid
Furo-Basan
Furo-Puren
Furo-puren
Furobeta
Furocot
Furodiurol
Furodrix
Furomen
Furomex
Furomide M.D
Furomide M.D.
Furorese
Furosan
Furose
Furosedon
Furosemid
Furosemida
Furosemida [INN-Spanish]
Furosemide
Furosemide "mita"
Furosemide (JP15/USP/INN)
Furosemide Monohydrochloride
Furosemide Monosodium Salt
Furosemide [USAN:INN:JAN]
Furosemidu
Furosemidu [Polish]
Furosemidum
Furosemidum [INN-Latin]
Furosemix
Furoside
Furosifar
Furosix
Furoter
Furovite
Fursemid
Fursemida
Fursemide
Fursol
Fusid
Fusidic acid
 
Golan
HMS1569E03
HMS1920B03
HMS2090K06
HMS2091H05
HMS501M17
HSDB 3086
Hissuflux
Hoe-058A
Hydol
Hydrenox
Hydrex
Hydro
Hydro-Rapid
Hydro-rapid
Hydroled
I04-0179
IDI1_000575
Impugan
Jenafusid
KBio1_000575
KBio2_001580
KBio2_004148
KBio2_006716
KBio3_001274
KBioGR_001259
KBioSS_001580
Katlex
Kofuzon
Kolkin
Kutrix
LB 502
LB-502
LS-204
Lasemid
Lasex
Lasiletten
Lasilix
Lasix
Lasix (TN)
Lasix (tn)
Lasix Retard
Lasix Special
Lasix, Frusemide, Furosemide
Laxur
Lazix
Leodrine
Less Diur
Liside
Logirene
Lowpston
Lowpstron
Luscek
MLS001066374
MLS001306403
Macasirool
Marsemide
Metflorylthiazidine
Methforylthiazidine
Mirfat
Mita
Moilarorin
MolPort-001-641-065
Myrosemide
NCGC00016241-01
NCGC00090893-01
NCGC00090893-02
NCGC00090893-03
NCGC00090893-05
NCGC00090893-06
NCI-C55936
NINDS_000575
NSC 269420
NSC269420
Nadis
Nelsix
Neo-Renal
Neo-renal
Nephron
Nicorol
Novosemide
Octan Draselny
Octan draselny
Odemase
Odemex
Oedemex
Olmagran
Oprea1_667724
Osyrol
Polysquall A
Prefemin
Prestwick0_000341
Prestwick1_000341
Prestwick2_000341
Prestwick3_000341
Prestwick_752
Profemin
Promedes
Promide
Protargen
Puresis
Radisemide
Radonna
Radouna
Retep
Rodiuran
Rontyl
Rosemide
Rosis
Rusyde
S1603_Selleck
SAM002264614
SMP1_000129
SMR000058202
SPBio_001129
SPBio_002322
SPECTRUM1500310
STK177334
Sal Diureticum
Sal diureticum
Salinex
Salix
Salix (brand of furosemide)
Salurex
Salurid
Saluron
Seguril
Selectofur
Sigasalur
Sisuril
Spectrum2_001005
Spectrum3_000437
Spectrum4_000560
Spectrum5_000744
Spectrum_001100
Spirofur
Synephron
TL8003563
Transit
Trofurit
UNII-7LXU5N7ZO5
UPCMLD-DP022
UPCMLD-DP022:001
Uremide
Uresix
Urex
Urex-M
Urian
Uridon
Uritol
Urosemide
Vergonil
Vesix
WLN: T5OJ B1MR CG FVQ DSZW
Yidoli
Zafimida
fulvamide
furosemide
furosemide ''mita''
less Diur
2
ChlorothiazideapprovedPhase 4758-94-62720
Synonyms:
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
58-94-6
6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-chloro-7-Sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
AC-18732
AC1L1EBB
Aldoclor
Alurene
BIDD:GT0635
BPBio1_000070
BRD-K88682005-001-05-9
BSPBio_000062
BSPBio_002003
C 4911
C07461
C2259
C4911_SIGMA
C7H6ClN3O4S2
CAS-58-94-6
CCRIS 5999
CHEBI:3640
CHEMBL842
CID2720
CPD000058429
Chloriazid
Chlorosal
Chlorothiazid
Chlorothiazide
Chlorothiazide (JAN/USP/INN)
Chlorothiazide Sodium
Chlorothiazide [USAN:INN:BAN]
Chlorothiazidum
Chlorothiazidum [INN-Latin]
Chlorthiazid
Chlorthiazide
Chlorthiazidum
Chlortiazid
Chlorurit
Chlotride
Chlrosal
Clorotiazida
Clorotiazida [INN-Spanish]
Clorotiazide
Clorotiazide [DCIT]
Clotride
D002740
D00519
DB00880
Diupres
Diuresal
Diuril
Diuril (TN)
Diuril Boluses
Diuril Boluses, Veterinary
Diuril, Chlotride, Chlorothiazide
Diurilix
Diurite
Diutrid
DivK1c_000675
EINECS 200-404-9
EU-0100254
Flumen
 
HMS1568D04
HMS1920K15
HMS2091C18
HMS502B17
HSDB 3030
I06-2278
IDI1_000675
KBio1_000675
KBio2_000594
KBio2_003162
KBio2_005730
KBio3_001223
KBioGR_000780
KBioSS_000594
LS-244
Lopac-C-4911
Lopac0_000254
MLS000028398
Mechlozid
Minzil
MolPort-003-666-143
MolPort-003-845-912
NCGC00015242-01
NCGC00015242-02
NCGC00015242-03
NCGC00015242-05
NCGC00015242-09
NCGC00091042-01
NCGC00091042-02
NCGC00091042-03
NCGC00091042-04
NCGC00091042-05
NINDS_000675
NSC 25693
NSC25693
Neo-Dema
Prestwick0_000251
Prestwick1_000251
Prestwick2_000251
Prestwick3_000251
Prestwick_56
S1641_Selleck
SAM002554891
SMR000058429
SPBio_000288
SPBio_002281
SPECTRUM1500180
Salisan
Salunil
Saluretil
Saluric
Sk-chlorothiazide
Spectrum2_000154
Spectrum3_000342
Spectrum4_000280
Spectrum5_001446
Spectrum_000134
Thiazide
UNII-77W477J15H
Urinex
Uroflux
WLN: T66 BSWM ENJ HG ISZW
Warduzide
Yadalan
chlorothiazide
chlorotiazida
component of Aldoclor
3
TolvaptanapprovedPhase 4, Phase 3, Phase 2, Phase 184150683-30-0216237, 443894
Synonyms:
( -)-4'-((7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-o-tolu-m-toluidide
150683-30-0
7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
AC1L50C9
C116664
CHEBI:327437
CHEMBL344159
CID216237
 
L001628
N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
OPC 41061
OPC-41061
PDSP1_001738
PDSP2_001721
Samsca
Tolvaptan
UNII-21G72T1950
benzazepine derivative, 32
4
Conivaptanapproved, investigationalPhase 4, Phase 3, Phase 2, Phase 120210101-16-9151171
Synonyms:
210101-16-9
4'-((4,5-dihydro-2-Methylimidazo(4,5-D)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide
4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilide
AC1L45SX
CHEBI:681850
CHEMBL1755
CID151171
Conivaptan
Conivaptan (INN)
Conivaptan [INN]
Conivaptan hydrochloride
D07748
DB00872
 
I14-8805
L001073
L001531
LS-187117
MolPort-005-940-873
N-[4-(2-methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide
N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide
PDSP1_001735
PDSP2_001718
UNII-0NJ98Y462X
YM 087
YM-087
YM087
ZINC12503187
5
MetolazoneapprovedPhase 4, Phase 11417560-51-94170
Synonyms:
17560-51-9
2-Methyl-3-O-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
5-25-09-00212 (Beilstein Handbook Reference)
7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-O-tolyl-6-quinazolinesulfonamide
7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide
7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide
AB00052055
AC1L1HKJ
BPBio1_000138
BRD-A61793559-001-05-7
BRN 0965506
BSPBio_000124
BSPBio_002422
CHEMBL878
CID4170
D00431
DB00524
Diulo
DivK1c_000275
EINECS 241-539-3
HMS1568G06
HMS1922L16
HMS2093P14
HMS500N17
HSDB 3367
IDI1_000275
KBio1_000275
KBio2_000936
KBio2_003504
KBio2_006072
KBioGR_000897
KBioSS_000936
LS-140226
M1195_SIGMA
MLS002153316
MLS002154200
Metalazone
Metalozone
Metenix
 
Metolazon
Metolazona
Metolazona [INN-Spanish]
Metolazone
Metolazone (JAN/USP/INN)
Metolazone [USAN:BAN:INN:JAN]
Metolazonum
Metolazonum [INN-Latin]
Microx
MolPort-003-666-780
Mykrox
Mykrox, Zaroxolyn, Diulo, Metolazone
Métolazone
NCGC00093985-01
NCGC00093985-02
NCGC00093985-03
NCGC00093985-04
NCGC00093985-05
NCGC00093985-06
NCGC00093985-08
NINDS_000275
Oldren
Prestwick0_000112
Prestwick1_000112
Prestwick2_000112
Prestwick3_000112
Prestwick_333
S1610_Selleck
SMR001230730
SPBio_001842
SPBio_002063
SPECTRUM2300325
SR 720-22
SR-720-22
Spectrum2_001741
Spectrum4_000229
Spectrum5_001237
Spectrum_000456
UNII-TZ7V40X7VX
Xuret
Zaroxolyn
Zaroxolyn (TN)
metolazone
6Antihypertensive AgentsPhase 4, Phase 13618
7Liver ExtractsPhase 4, Phase 3, Phase 2, Phase 13572
8diureticsPhase 4, Phase 3, Phase 2, Phase 11194
9Contraceptives, OralPhase 4, Phase 3, Phase 13734
10HormonesPhase 4, Phase 3, Phase 2, Phase 111748
11Vasoconstrictor AgentsPhase 4, Phase 3, Phase 2, Phase 11303
12Arginine VasopressinPhase 4, Phase 3, Phase 2, Phase 1264
13VasopressinsPhase 4, Phase 3, Phase 2, Phase 1260
14CoagulantsPhase 4, Phase 3, Phase 2, Phase 11042
15Sodium Chloride Symporter InhibitorsPhase 4, Phase 1399
16HemostaticsPhase 4, Phase 3, Phase 2, Phase 11082
17Natriuretic AgentsPhase 4, Phase 3, Phase 2, Phase 11403
18Pharmaceutical SolutionsPhase 47004
19TorsemidePhase 421
20Sodium Potassium Chloride Symporter InhibitorsPhase 4, Phase 1130
21arginineNutraceuticalPhase 4, Phase 3, Phase 2, Phase 1364
22
SpironolactoneapprovedPhase 2, Phase 31591952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
23
MidodrineapprovedPhase 2, Phase 340133163-28-74195
Synonyms:
( -)-Midodrin hydrochloride
( -)-Midodrine hydrochloride
()-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol
(+-)-1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride
(+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide monohydrochloride
(+-)-2-amino-N-(beta-Hydroxy-2,5-dimethoxyphenethyl)acetamide
(+-)-Midodrine hydrochloride
(+/-)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol
(RS)-N'-(beta-Hydroxy-2,5-dimethoxy-phenethyl)glycinamid
1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol
1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride
2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamid
2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethyl)acetamide
2-Amino-N-(2,5-dimethoxy-beta-hydroxyphenethylacetamide
2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide monohydrochloride
2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hyyroxyethyl)acetamide monohydrochloride
2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide hydrochloride
3092-17-9
3092-17-9 (mono-hydrochloride)
42794-76-3
42794-76-3 (Parent)
43218-56-0
97476-58-9
A 4020 Linz
A-4020 Linz
AB00053715
AC1L1HMJ
AC1L2BU9
Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-, monohydrochloride
Acetamide, 2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)-, hydrochloride
Alphamine
Amatine
BPBio1_000157
BRD-A79981887-003-05-7
BSPBio_000141
BSPBio_003150
C07890
C12H18N2O4
C12H18N2O4.HCl
CHEBI:31847
CHEBI:6933
CHEMBL1200461
CID18340
CID4195
CPD000058833
D01307
D08220
DB00211
DL-N1-(beta-Hydroxy-2,5-dimethoxyphenethyl)glycinamid
DivK1c_000955
EINECS 255-945-3
EINECS 256-148-3
Gutron
HMS1568H03
HMS1922O03
Hipertan
I06-0865
IDI1_000955
KBio1_000955
KBio2_002121
KBio2_004689
KBio2_007257
KBio3_002650
 
KBioGR_000763
KBioSS_002121
LS-174957
LS-8042
LS-8052
M8277_FLUKA
M8277_SIGMA
MIDODRINE HYDROCHLORIDE
MLS001332567
MLS001332568
MLS002154233
Metligene
Midamine
Midodrin
Midodrina
Midodrina [INN-Spanish]
Midodrine
Midodrine (INN)
Midodrine HCL
Midodrine Hydrochloride
Midodrine Monohydrochloride
Midodrine [BAN:INN]
Midodrine [INN:BAN]
Midodrine hydrochloride
Midodrine hydrochloride (JAN/USAN)
Midodrine hydrochloride [USAN:JAN]
Midodrine hydrochloride [USAN]
Midodrinum
Midodrinum [INN-Latin]
MolPort-003-666-473
MolPort-003-849-221
N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]glycinamide
N-{2-[2,5-bis(methyloxy)phenyl]-2-hydroxyethyl}glycinamide
NCGC00095311-01
NCGC00178238-01
NCGC00178238-02
NINDS_000955
Prestwick0_000191
Prestwick1_000191
Prestwick2_000191
Prestwick3_000191
Prestwick_625
Pro-Amatine
Pro-Amatine (TN)
ProAmatine
Proamatine
SAM002564219
SBB066174
SMR000058833
SPBio_001390
SPBio_002062
SPECTRUM1503257
ST-1085
Spectrum2_001545
Spectrum3_001585
Spectrum4_000192
Spectrum5_000962
Spectrum_001641
St 1085
St. Peter 224
TL8002369
TS 701
UNII-59JV96YTXV
UNII-6YE7PBM15H
[+/-]-1-[2,5-Dimethoxyphenyl]-2-glycinamidoethanol
midodrine
24
SatavaptanPhase 3, Phase 211185913-78-47029
Synonyms:
308145-17-7
Aquilda
Benzamide, N-(1,1-dimethylethyl)-4-((cis-5'-ethoxy-4-(2-(4-morpholinyl)ethoxy)-2'-oxospiro(cyclohexane-1,3'-(3H)indol)-1'(2'H)-yl)sulfonyl)-3-methoxy-, phosphate (1:1)
CID9810773
 
SR-121463
SR-121463A
SR-121463B
SR-121463F
Satavaptan
25Peripheral Nervous System AgentsPhase 2, Phase 318510
26Neurotransmitter AgentsPhase 2, Phase 314795
27Diuretics, Potassium SparingPhase 2, Phase 31445
28Hormone AntagonistsPhase 2, Phase 310002
29Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 2, Phase 39988
30Adrenergic AgonistsPhase 2, Phase 32331
31Adrenergic alpha-AgonistsPhase 2, Phase 31300
32Adrenergic AgentsPhase 2, Phase 34204
33Mineralocorticoid Receptor AntagonistsPhase 2, Phase 3284
34MineralocorticoidsPhase 2, Phase 3301
35
Nitric OxideapprovedPhase 256410102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
Inomax
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
36
Phentermineapproved, illicitPhase 240122-09-84771
Synonyms:
(alpha,alpha)-Dimethylphenethylamine
1,1-Dimethyl-2-phenylethylamine
1-(2-Methylphenyl)-2-propylamin
1-(2-Tolyl)-2-propylamine
1197-21-3 (hydrochloride)
122-09-8
12674-13-4
2-Amino-2-methyl-1-phenylpropane
2-Methyl-1-phenyl-2-propanamine
2-Phenyl-tert-butylamine
2-methyl-1-phenylpropan-2-amine
35373-71-8
9008-94-0
AC1L1IX2
AKOS004123261
Adipex-P
Adipex-p
AmbkkkkK744
BRN 0970319
C07438
CHEBI:8080
CHEMBL1574
CID4771
D05458
DB00191
DEA No. 1640
Duromine
EINECS 204-522-1
Fastin
Fentermina
Fentermina [INN-Spanish]
HMS2093B16
HSDB 3158
InChI=1/C10H15N/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8,11H2,1-2H
Inoamin
Ionamin
Ionamine
LS-103327
Linyl
Lipopill
Lonamin
 
Mirapront
MolPort-002-043-208
Normephentermine
Obenix
Obermine
Oby-Trim
Omnibex
Ona Mast
Ortetamin
Ortetamina
Ortetamine [INN]
Ortetaminum
Phentercot
Phentermine (USAN/INN)
Phentermine HCl
Phentermine Hydrochloride
Phentermine Resin 30
Phentermine [USAN:INN:BAN]
Phentermine resin complex
Phenterminum
Phenterminum [INN-Latin]
Phentride
Phentrol
Phentrol 2
Phentrol 3
Phentrol 4
Phenyl-tert-butylamine
Phenyl-tertiary-butylamine
Pro-Fast
RCRA waste no. P046
RCRA waste number P046
Suprenza
UNII-C045TQL4WP
UNII-VF4N11KKKR
Wilpo
Zantryl
alpha,alpha-Dimethyl-beta-phenylethylamine
alpha,alpha-Dimethylbenzeneethanamine
alpha,alpha-Dimethylphenethylamine
alpha-Benzylisopropylamine
alpha.,.alpha.-dimethyl-Benzeneethanamine
phentermine
37Protective AgentsPhase 25651
38SRX246Phase 1, Phase 25
39Respiratory System AgentsPhase 23931
40Vasodilator AgentsPhase 22926
41AntioxidantsPhase 22442
42Anti-Asthmatic AgentsPhase 22796
43Bronchodilator AgentsPhase 22377
44Endothelium-Dependent Relaxing FactorsPhase 2225
45Omega-N-MethylargininePhase 254
46
MetforminapprovedPhase 11645657-24-9, 1115-70-414219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMBG
DMGG
Diabefagos
Diabetosan
Diabex
Diaformin
Dianben
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Meguan
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin Hydrochloride
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
Obimet
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
47Calcium, DietaryPhase 14678
48Hypoglycemic AgentsPhase 14503
49
Hydrochlorothiazideapproved38758-93-53639
Synonyms:
125727-50-6
3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothi
3,4-Dihydrochlorothiazide
58-93-5
6-Chloro-7-sulfamoyl-3, 4-dihy
8049-49-8
AB00052012
AC-11072
AC1L1GDT
AC1Q55FM
AF-614/30832002
AKOS000121373
ARONIS24316
Acesistem
Acuilix
Acuretic
Aldactazide
Aldactazide 25/25
Aldazida
Aldectazide 50/50
Aldoril
Ambap58-93-5
Apo-Hydro
Apresazide
Aquarills
Aquarius
Aquazide H
Aquazide-H
BAS 00371709
BIDD:GT0153
BPBio1_000019
BRD-K13078532-001-05-2
BRN 0625101
BSPBio_000017
BSPBio_002132
Bio-0714
Bremil
Briazide
C7H8ClN3O4S2
CAS-58-93-5
CCRIS 2082
CHEMBL435
CID3639
CPD000035778
Caplaril
Capozide
Carozide
Catiazida
Chlorizide
Chlorosulthiadil
Chlorothiazide
Chlorsulfonamidodihydrobenzothiadiazine dioxide
Chlorzide
Chlothia
Cidrex
Clorana
Component of Butizide Prestabs
Concor Plus
Condiuren
D00340
D006852
DB00999
Diaqua
Dichlorosal
Dichlorotride
Dichlothiazide
Dichlotiazid
Dichlotride
Diclotride
Dicyclotride
Didral
Dihydran
Dihydrochlorothiazid
Dihydrochlorothiazide
Dihydrochlorothiazidum
Dihydrochlorurit
Dihydrochlorurite
Dihydroxychlorothiazidum
Direma
Disalunil
Disothiazid
Diu 25 Vigt
Diu-Melusin
Diu-melusin
Diuril
Diurogen
DivK1c_000289
Dixidrasi
Drenol
Dyazide
EINECS 200-403-3
EU-0100614
Esidrex
Esidrix
Esidrix (TN)
Esimil
Esoidrina
FT-0082750
Fluvin
H 4759
H1274
H2910_SIAL
H4759_SIAL
HCT
HCT-Isis
HCTZ
HCZ
HMS1568A19
HMS1920D19
HMS2091L05
HMS500O11
HMS553N04
HSDB 3096
Hidril
Hidro-Niagrin
Hidrochlortiazid
Hidroclorotiazida
Hidroclorotiazida [INN-Spanish]
Hidroronol
Hidrosaluretil
Hidrotiazida
Hyclosid
Hydrex-semi
Hydril
Hydro Par
Hydro-Aquil
Hydro-D
Hydro-Diuril
Hydro-Saluric
Hydro-T
Hydro-chlor
HydroDIURIL
Hydrochlorat
Hydrochloro Thiazide
Hydrochlorot
Hydrochlorothiazid
Hydrochlorothiazide
Hydrochlorothiazide (JP15/USP/INN)
Hydrochlorothiazide Intensol
Hydrochlorothiazide [INN:BAN:JAN]
 
Hydrochlorothiazidum
Hydrochlorothiazidum [INN-Latin]
Hydrochlorthiazide
Hydrochlorthiazidum
Hydrocot
Hydrodiuretic
Hydrodiuril
Hydropres
Hydrosaluric
Hydrothide
Hydrozide
Hydrozide Injection, Veterinary
Hypothiazid
Hypothiazide
Hytrid
Hyzaar
I09-0531
IDI1_000289
Idroclorotiazide
Idroclorotiazide [DCIT]
Idrotiazide
Inderide
Inderide 80/25
Indroclor
Ivaugan
Jen-Diril
KBio1_000289
KBio2_001357
KBio2_003925
KBio2_006493
KBio3_001352
KBioGR_000351
KBioSS_001357
LS-243
Lopac-H-4759
Lopac0_000614
Lopressor HCT
Lotensin HCT
Lotensin Hct
MLS000069619
Manuril
Maschitt
Maxzide
Maybridge Compound 10
Maybridge1_004336
Mazide 25 mg
Medozide
Megadiuril
Microzide
Microzide (TN)
Mictrin
Mikorten
Modurcen
Moduretic
MolPort-000-144-465
NCGC00015508-01
NCGC00015508-02
NCGC00015508-03
NCGC00015508-07
NCGC00015508-12
NCGC00021906-03
NCGC00021906-04
NCGC00021906-05
NCGC00021906-06
NCGC00021906-07
NCGC00021906-08
NCI-C55925
NCI60_004317
NINDS_000289
NSC 53477
NSC53477
Natrinax
Nefrix
Nefrol
Neo-Codema
Neo-Flumen
Neo-Minzil
Neo-codema
Neoflumen
Newtolide
Novodiurex
Oprea1_357174
Oretic
Pantemon
Panurin
Prestwick0_000009
Prestwick1_000009
Prestwick2_000009
Prestwick3_000009
Prestwick_263
Prinzide
Raunova Plus
Ro-Hydrazide
Ro-hydrazide
Roxane
S1708_Selleck
SAM002554901
SMR000035778
SPBio_001259
SPBio_001938
SPECTRUM1500335
STK315354
Saldiuril
Sectrazide
Selozide
Ser-Ap-Es
Servithiazid
Spectrum2_001040
Spectrum3_000456
Spectrum4_000006
Spectrum5_000824
Spectrum_000877
Spironazide
Su 5879
Tandiur
Thiaretic
Thiuretic
Thlaretic
Timolide
UNII-0J48LPH2TH
Unazid
Unipres
Urodiazin
Urozide
Vaseretic
Vetidrex
WLN: T66 BSWM EM DHJ HG ISZW
ZINC00896569
Ziac
Zide
adiazine-1,1-dioxide
component of Aldactazide
component of Aldoril
component of Caplaril
component of Cyclex
component of Dyazide
component of Esimil
diclot ride
dro-2H-1,2,4-benzothiadiazine 1,1-dioxide
hydrochlorothiazide
panurin dichloride
50
Amilorideapproved452016-88-816231
Synonyms:
17440-83-4 (hydrochloride)
1f5l
2016-88-8 (anhydrous hydrochloride)
2609-46-3
3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide
3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
AB00053415
AC-13631
AC1L27IZ
AC1Q3POC
AMILORIDE
AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8))
Amiclaran
Amiclaran (TN)
Amikal (Hydrochloride dihydrate)
Amilorid
Amilorida
Amilorida [INN-Spanish]
Amiloride
Amiloride (INN)
Amiloride HCL
Amiloride Hydrochloride
Amiloride [INN:BAN]
Amiloride hydrochloride hydrate
Amiloridum
Amiloridum [INN-Latin]
Amipramidin
Amipramidine
Amipramizid
Amipramizide
Amiprazidine
Amyloride
BCBcMAP01_000101
BIDD:GT0466
BPBio1_000015
BRD-K97181089-003-02-3
BRD-K97181089-310-03-0
BSPBio_000013
BSPBio_001572
BSPBio_001826
Bio1_000359
Bio1_000848
Bio1_001337
Bio2_000292
Bio2_000772
C06821
C6H8ClN7O
CCRIS 6545
CHEBI:2639
CHEMBL945
CID16231
CPD-10324
D07447
DB00594
Diurex
DivK1c_000182
 
EINECS 220-024-7
Guanamprazin
Guanamprazine
HMS1791O14
HMS1989O14
HMS2089H05
IDI1_000182
IDI1_034042
KBio1_000182
KBio2_000292
KBio2_000394
KBio2_002860
KBio2_002962
KBio2_005428
KBio2_005530
KBio3_000583
KBio3_000584
KBio3_001326
KBioGR_000292
KBioGR_000544
KBioSS_000292
KBioSS_000394
LS-1094
Lopac-A-7410
Lopac0_000111
MK-870 (Hydrochloride dihydrate)
MLS000758249
MLS001060798
Midamor
Midamor (Hydrochloride dihydrate)
MolPort-005-934-472
MolPort-005-937-651
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide
N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid
NCGC00015089-01
NCGC00015089-02
NCGC00015089-12
NCGC00024443-02
NCGC00024443-05
NCGC00024443-06
NCGC00024443-07
NCGC00024443-09
NINDS_000182
Prestwick0_000007
Prestwick1_000007
Prestwick2_000007
Prestwick3_000007
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride
SMR000449325
SMR000486264
SPBio_000136
SPBio_001934
ST079279
Spectrum2_000118
Spectrum3_000293
Spectrum4_000132
Spectrum5_000776
Spectrum_000034
Tocris-0890
UNII-7DZO8EB0Z3
ZINC04340269

Interventional clinical trials:

(show top 50)    (show all 123)
idNameStatusNCT IDPhase
1Tolvaptan/Ultrafiltration in the Treatment of Acute Heart FailureCompletedNCT01863511Phase 4
2Effects on Exercise Hemodynamics of Vasopressin Blockade by Conivaptan Infusion in Heart Failure PatientsCompletedNCT01752543Phase 4
3Effect of Tolvaptan on Mid- to Long-term Prognosis of Heart Failure PatientsCompletedNCT01439009Phase 4
4Pilot Study of Using Copeptin to Predict Response to TolvaptanCompletedNCT01346072Phase 4
5Tolvaptan for Ascites in Cirrhotic PatientsCompletedNCT01292304Phase 4
6Tolvaptan in Hyponatremic Cancer PatientsCompletedNCT01199198Phase 4
7A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic HyponatremiaCompletedNCT00435591Phase 4
8The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves ReplacementRecruitingNCT02644616Phase 4
9Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart FailureRecruitingNCT02606253Phase 4
10Outcome and Treatment Quality Study of Tolvaptan to Treat Hyponatremia in Patients With Heart FailureRecruitingNCT02352285Phase 4
11Aquaresis Utility for Hyponatremic Acute Heart Failure StudyRecruitingNCT02183792Phase 4
12Effects of Tolvaptan in Healthy AdultsRecruitingNCT01973140Phase 4
13Effect of Samsca on Control of Hyponatremia and Extracellular Fluid in Cirrhotic Patients With AscitesRecruitingNCT01552590Phase 4
14Regional Tolvaptan RegistryNot yet recruitingNCT02666651Phase 4
15Tolvaptan For Worsening Outpatient Heart Failure: Role of Copeptin In Identifying RespondersNot yet recruitingNCT02476409Phase 4
16Tolvaptan for Hyponatremia in Cirrhotic Patients With AscitesNot yet recruitingNCT01716611Phase 4
17Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and HyponatremiaTerminatedNCT01890694Phase 4
18Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU PatientsTerminatedNCT00727090Phase 4
19The Use of Tolvaptan to Prevent Renal Dysfunction in High Risk Patients With Heart Failure-Pilot StudyWithdrawnNCT01663662Phase 4
20Diuretic and Renal Effects of Vaprisol When Administered Along With Furosemide and Nesiritide Continuous InfusionWithdrawnNCT00806910Phase 4
21DILIPO (DILutIonal HyPOnatremia)CompletedNCT00274326Phase 3
22International, Multicenter, Study of One-year, Open-label, Titrated Oral Tolvaptan Tablet Administration in Patients With Chronic HyponatremiaCompletedNCT02449044Phase 3
23Efficacy and Safety of Tolvaptan in Cirrhotic Patients With HyponatremiaCompletedNCT01850940Phase 3
24Efficacy and Safety Study of Tolvaptan to Treat Patients With Cardiac EdemaCompletedNCT01651156Phase 3
25Targeting Acute Congestion With Tolvaptan in Congestive Heart FailureCompletedNCT01644331Phase 3
26Efficacy and Safety of Tolvaptan in the Treatment of Cardiac-Induced Edema in Patients With Heart FailureCompletedNCT01618448Phase 3
27Effect of Tolvaptan on Cognitive Function in CirrhosisCompletedNCT01556646Phase 3
28Phase III Study of Tolvaptan Tablet to Treat Cirrhosis AscitesCompletedNCT01349348Phase 3
29A Study to Investigate the Long-term Safety and Efficacy of Tolvaptan in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) [Extension of Trial 156-04-251 in Japan]CompletedNCT01280721Phase 3
30Open-Label Tolvaptan Study in Subjects With ADPKDCompletedNCT01214421Phase 3
31A Study to Investigate Pharmacodynamics and Pharmacokinetics of OPC-41061 in Patients With Hepatic EdemaCompletedNCT01114828Phase 3
32A Trial to Investigate the Efficacy of OPC-41061 Administered at a Dose of 7.5 mg in Patients With Hepatic EdemaCompletedNCT01050530Phase 3
33A Trial of OPC-41061 in Patients With Hepatic Edema - Investigation of the Safety of Treatment at 7.5 mg Beyond 7 Days and of the Effect of Dose Escalation to 15 mgCompletedNCT01048788Phase 3
34A Long-term Administration Study of OPC-41061 in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) (2) [Extension of Study 156-05-002]CompletedNCT01022424Phase 3
35Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic PatientsCompletedNCT00550459Phase 3
36A Study of OPC-41061 in Subjects With Cardiac-induced Edema (Congestive Heart Failure)CompletedNCT00544869Phase 3
37A Clinical Pharmacological Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure)CompletedNCT00525265Phase 3
38Study of Efficacy & Safety for 3 Infusion Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic HyponatremiaCompletedNCT00478192Phase 3
39A Double-blind, Placebo-controlled Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure)CompletedNCT00462670Phase 3
40Tolvaptan Phase 3 Efficacy and Safety Study in ADPKDCompletedNCT00428948Phase 3
41Study of IV YM087 to Assess Efficacy and Safety in Patients With Euvolemic or Hypervolemic HyponatremiaCompletedNCT00380575Phase 3
42An Open-Label Study of YM087 (Conivaptan) in Patients With Euvolemic or Hypervolemic HyponatremiaCompletedNCT00379847Phase 3
43Cirrhotic Ascites Treatment With Satavaptan in Patients With Ascites Due to Cirrhosis of the Liver (CATS)CompletedNCT00358878Phase 3
44Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone SecretionCompletedNCT00264927Phase 3
45Safety and Efficacy of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone SecretionCompletedNCT00264914Phase 3
46"SALT-2 Trial" Study of Ascending Levels of Tolvaptan in HyponatremiaCompletedNCT00201994Phase 3
47“SALT Trial” Study of Ascending Levels of Tolvaptan in HyponatremiaCompletedNCT00072683Phase 3
48EVEREST: Efficacy of Vasopressin Antagonism in hEart failuRE: Outcome Study With TolvaptanCompletedNCT00071331Phase 3
49A Trial of Tolvaptan in Children and Adolescent Subjects With Euvolemic and Hypervolemic HyponatremiaRecruitingNCT02442674Phase 3
50An Extension Follow-up Trial to Evaluate the Long-term Safety of Children and Adolescent Subjects With Euvolemic or Hypervolemic HyponatremiaRecruitingNCT02020278Phase 3

Search NIH Clinical Center for Diabetes Insipidus, Nephrogenic


Cochrane evidence based reviews: diabetes insipidus, nephrogenic

Genetic Tests for Diabetes Insipidus, Nephrogenic

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Genetic tests related to Diabetes Insipidus, Nephrogenic:

id Genetic test Affiliating Genes
1 Nephrogenic Diabetes Insipidus22 AVPR2
2 Nephrogenic Diabetes Insipidus, Autosomal22 AQP2
3 Nephrogenic Diabetes Insipidus, X-Linked22 AVPR2

Anatomical Context for Diabetes Insipidus, Nephrogenic

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MalaCards organs/tissues related to Diabetes Insipidus, Nephrogenic:

33
Heart, Kidney, Liver, Brain, Bone, Monocytes, Endothelial

Animal Models for Diabetes Insipidus, Nephrogenic or affiliated genes

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MGI Mouse Phenotypes related to Diabetes Insipidus, Nephrogenic:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.1AQP1, AQP2, AQP3, AQP4, ATP6V0A4, AVP
2MP:00107686.8AQP1, AQP2, AQP3, AQP4, ATP6V0A4, AVP
3MP:00053676.7AQP1, AQP2, AQP3, AQP4, AQP7, ATP6V0A4
4MP:00053786.5AQP1, AQP2, AQP3, AQP4, AQP7, ATP6V0A4
5MP:00053766.0AQP1, AQP2, AQP3, AQP4, AQP7, ATP6V0A4

Publications for Diabetes Insipidus, Nephrogenic

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Articles related to Diabetes Insipidus, Nephrogenic:

idTitleAuthorsYear
1
Diabetes insipidus, nephrogenic type, complicating pregnancy: a case report. (5529923)
1970

Variations for Diabetes Insipidus, Nephrogenic

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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Insipidus, Nephrogenic:

67 (show all 109)
id Symbol AA change Variation ID SNP ID
1AQP2p.Gly64ArgVAR_004401
2AQP2p.Arg187CysVAR_004402
3AQP2p.Ser216ProVAR_004403
4AQP2p.Leu22ValVAR_015239
5AQP2p.Leu28ProVAR_015240
6AQP2p.Ala47ValVAR_015241
7AQP2p.Asn68SerVAR_015242
8AQP2p.Val71MetVAR_015243
9AQP2p.Thr125MetVAR_015244rs104894333
10AQP2p.Thr126MetVAR_015245rs104894330
11AQP2p.Ala147ThrVAR_015246
12AQP2p.Val168MetVAR_015247
13AQP2p.Gly175ArgVAR_015248
14AQP2p.Cys181TrpVAR_015249
15AQP2p.Pro185AlaVAR_015250
16AQP2p.Ala190ThrVAR_015251
17AQP2p.Trp202CysVAR_015253
18AQP2p.Glu258LysVAR_015254
19AQP2p.Pro262LeuVAR_015255
20AQP2p.Gln57ProVAR_015256rs28931580
21AQP2p.Gly100ValVAR_015257rs28929477
22AQP2p.Ala70AspVAR_062585
23AQP2p.Gly100ArgVAR_062586
24AQP2p.Gly180SerVAR_062587
25AQP2p.Arg187HisVAR_062588
26AQP2p.Arg254LeuVAR_062589
27AQP2p.Arg254GlnVAR_062590
28AQP2p.Thr108MetVAR_071370
29AVPR2p.Leu44ProVAR_003517
30AVPR2p.His80ArgVAR_003520
31AVPR2p.Val88MetVAR_003521
32AVPR2p.Arg106CysVAR_003522
33AVPR2p.Cys112ArgVAR_003523
34AVPR2p.Arg113TrpVAR_003524rs28935496
35AVPR2p.Ser126PheVAR_003525
36AVPR2p.Tyr128SerVAR_003526
37AVPR2p.Ala132AspVAR_003527
38AVPR2p.Arg137HisVAR_003528
39AVPR2p.Arg143ProVAR_003529
40AVPR2p.Trp164SerVAR_003531
41AVPR2p.Ser167LeuVAR_003532
42AVPR2p.Ser167ThrVAR_003533
43AVPR2p.Arg181CysVAR_003534
44AVPR2p.Gly185CysVAR_003535
45AVPR2p.Arg202CysVAR_003536
46AVPR2p.Arg203CysVAR_003537
47AVPR2p.Tyr205CysVAR_003538
48AVPR2p.Tyr280CysVAR_003541
49AVPR2p.Pro286LeuVAR_003543
50AVPR2p.Pro286ArgVAR_003544
51AVPR2p.Leu292ProVAR_003545
52AVPR2p.Leu309ProVAR_003546
53AVPR2p.Asn317LysVAR_003547
54AVPR2p.Trp323SerVAR_003548
55AVPR2p.Leu43ProVAR_015297
56AVPR2p.Ile46LysVAR_015298
57AVPR2p.Leu53ArgVAR_015299
58AVPR2p.Asn55AspVAR_015300
59AVPR2p.Asn55HisVAR_015301
60AVPR2p.Leu59ProVAR_015302
61AVPR2p.Leu62ProVAR_015304
62AVPR2p.Leu81PheVAR_015305
63AVPR2p.Leu83ProVAR_015306
64AVPR2p.Leu83GlnVAR_015307
65AVPR2p.Ala84AspVAR_015308
66AVPR2p.Asp85AsnVAR_015309
67AVPR2p.Gln92ArgVAR_015310
68AVPR2p.Leu94GlnVAR_015311
69AVPR2p.Pro95LeuVAR_015312
70AVPR2p.Trp99ArgVAR_015313
71AVPR2p.Arg104CysVAR_015314
72AVPR2p.Phe105ValVAR_015315
73AVPR2p.Gly107GluVAR_015316
74AVPR2p.Cys112TyrVAR_015317
75AVPR2p.Gly122ArgVAR_015318
76AVPR2p.Met123LysVAR_015319
77AVPR2p.Ser127PheVAR_015320
78AVPR2p.Ile130PheVAR_015321
79AVPR2p.Leu135ProVAR_015322
80AVPR2p.Ala163ProVAR_015324
81AVPR2p.Pro173SerVAR_015325
82AVPR2p.Gln174LeuVAR_015326
83AVPR2p.Asp191GlyVAR_015327
84AVPR2p.Gly201AspVAR_015328
85AVPR2p.Thr204AsnVAR_015329
86AVPR2p.Val206AspVAR_015330
87AVPR2p.Thr207AsnVAR_015331
88AVPR2p.Ile209PheVAR_015332
89AVPR2p.Phe214SerVAR_015333
90AVPR2p.Pro217ThrVAR_015335
91AVPR2p.Leu219ProVAR_015336
92AVPR2p.Leu219ArgVAR_015337
93AVPR2p.Met272LysVAR_015339
94AVPR2p.Val277AlaVAR_015340
95AVPR2p.Leu282ProVAR_015341
96AVPR2p.Pro286SerVAR_015342
97AVPR2p.Phe287LeuVAR_015343
98AVPR2p.Leu289ProVAR_015344
99AVPR2p.Ala294ProVAR_015345
100AVPR2p.Leu309ArgVAR_015346
101AVPR2p.Ser315ArgVAR_015347
102AVPR2p.Cys319ArgVAR_015349
103AVPR2p.Asn321AspVAR_015350
104AVPR2p.Asn321LysVAR_015351
105AVPR2p.Asn321TyrVAR_015352
106AVPR2p.Pro322HisVAR_015353
107AVPR2p.Pro322SerVAR_015354
108AVPR2p.Trp323ArgVAR_015355
109AVPR2p.Gly122AspVAR_062591

Clinvar genetic disease variations for Diabetes Insipidus, Nephrogenic:

5 (show all 20)
id Gene Variation Type Significance SNP ID Assembly Location
1AVPR2AVPR2, 1-BP DEL, 733GdeletionPathogenic
2AVPR2NM_000054.4(AVPR2): c.395C> A (p.Ala132Asp)single nucleotide variantPathogenicrs104894747GRCh37Chr X, 153171355: 153171355
3AVPR2NM_000054.4(AVPR2): c.553G> T (p.Gly185Cys)single nucleotide variantPathogenicrs104894748GRCh37Chr X, 153171513: 153171513
4AVPR2NM_000054.4(AVPR2): c.614A> G (p.Tyr205Cys)single nucleotide variantPathogenicrs104894749GRCh37Chr X, 153171574: 153171574
5AVPR2NM_000054.4(AVPR2): c.607C> T (p.Arg203Cys)single nucleotide variantPathogenicrs104894750GRCh37Chr X, 153171567: 153171567
6AVPR2NM_000054.4(AVPR2): c.337C> T (p.Arg113Trp)single nucleotide variantPathogenicrs28935496GRCh37Chr X, 153171297: 153171297
7AVPR2AVPR2, 1-BP INSinsertionPathogenic
8AVPR2NM_000054.4(AVPR2): c.213G> A (p.Trp71Ter)single nucleotide variantPathogenicrs104894751GRCh37Chr X, 153171173: 153171173
9AVPR2NM_000054.4(AVPR2): c.839A> G (p.Tyr280Cys)single nucleotide variantPathogenicrs104894752GRCh37Chr X, 153171799: 153171799
10AVPR2NM_000054.4(AVPR2): c.1009C> T (p.Arg337Ter)single nucleotide variantPathogenicrs104894753GRCh37Chr X, 153172075: 153172075
11AVPR2NM_000054.4(AVPR2): c.253G> A (p.Asp85Asn)single nucleotide variantPathogenicrs104894754GRCh37Chr X, 153171213: 153171213
12AVPR2NM_000054.4(AVPR2): c.602G> A (p.Gly201Asp)single nucleotide variantPathogenicrs104894755GRCh37Chr X, 153171562: 153171562
13AVPR2AVPR2, 1-BP INS, 804GinsertionPathogenic
14AVPR2AVPR2, 1-BP DEL, 102GdeletionPathogenic
15AVPR2NM_000054.4(AVPR2): c.410G> A (p.Arg137His)single nucleotide variantPathogenicrs104894756GRCh37Chr X, 153171370: 153171370
16AVPR2NM_000054.4(AVPR2): c.541C> T (p.Arg181Cys)single nucleotide variantPathogenicrs104894757GRCh37Chr X, 153171501: 153171501
17AVPR2NM_000054.4(AVPR2): c.313T> G (p.Phe105Val)single nucleotide variantPathogenicrs104894758GRCh37Chr X, 153171273: 153171273
18AVPR2NM_000054.4(AVPR2): c.137T> A (p.Ile46Lys)single nucleotide variantPathogenicrs104894759GRCh37Chr X, 153171097: 153171097
19AVPR2NM_000054.4(AVPR2): c.310C> T (p.Arg104Cys)single nucleotide variantPathogenicrs104894760GRCh37Chr X, 153171270: 153171270
20AVPR2NM_000054.4(AVPR2): c.388A> T (p.Ile130Phe)single nucleotide variantPathogenicrs796052096GRCh37Chr X, 153171348: 153171348

Expression for genes affiliated with Diabetes Insipidus, Nephrogenic

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Search GEO for disease gene expression data for Diabetes Insipidus, Nephrogenic.

Pathways for genes affiliated with Diabetes Insipidus, Nephrogenic

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Pathways related to Diabetes Insipidus, Nephrogenic according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8CLCNKA, SLC12A1
28.9AQP2, AQP3, AQP4, AVP, AVPR2
38.8AQP1, AQP4, AQP7
4
Show member pathways
8.0AQP1, AQP2, AQP3, AQP4, AQP7, FGF23
5
Show member pathways
7.5AQP1, AQP2, AQP3, AQP4, AQP7, AVP
6
Show member pathways
6.2AQP1, AQP2, AQP3, AQP4, AQP7, ATP6V0A4

GO Terms for genes affiliated with Diabetes Insipidus, Nephrogenic

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Cellular components related to Diabetes Insipidus, Nephrogenic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:00160207.9AQP1, AQP2, AQP3, AQP7, CLCNKA, LNPEP

Biological processes related to Diabetes Insipidus, Nephrogenic according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of systemic arterial blood pressureGO:000308410.6AVP, AVPR2
2cellular water homeostasisGO:000999210.6AQP1, AQP2
3cellular response to mercury ionGO:007128810.5AQP1, AQP2
4positive regulation of vasoconstrictionGO:004590710.3AVP, AVPR2
5odontogenesisGO:004247610.2AQP1, AQP3
6excretionGO:000758810.1ATP6V0A4, AVPR2
7water transportGO:00068339.9AQP1, AQP3, AVP
8renal water homeostasisGO:00030919.8AQP1, AQP3, AVP, AVPR2
9transportGO:00068108.8AQP1, AQP3, CLCNKA, SLC12A1
10glycerol transportGO:00157938.4AQP1, AQP2, AQP3, AQP4, AQP7, MIP
11ion transmembrane transportGO:00342208.1AQP2, AQP4, ATP6V0A4, CLCNKA, MIP, SLC12A1
12transmembrane transportGO:00550856.8AQP1, AQP2, AQP3, AQP4, AQP7, ATP6V0A4

Molecular functions related to Diabetes Insipidus, Nephrogenic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transporter activityGO:00052159.1AQP2, AQP3, AQP4, MIP

Sources for Diabetes Insipidus, Nephrogenic

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet