MCID: DBT009
MIFTS: 68

Diabetes Mellitus malady

Endocrine category

Summaries for Diabetes Mellitus

Sources:
34MedlinePlus, 3CDC, 46Novus Biologicals, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. glucose comes from the foods you eat. insulin is a hormone that helps the glucose get into your cells to give them energy. with type 1 diabetes, your body does not make insulin. with type 2 diabetes, the more common type, your body does not make or use insulin well. without enough insulin, the glucose stays in your blood. over time, having too much glucose in your blood can cause serious problems. it can damage your eyes, kidneys, and nerves. diabetes can also cause heart disease, stroke and even the need to remove a limb. pregnant women can also get diabetes, called gestational diabetes. a blood test can show if you have diabetes. exercise, weight control and sticking to your meal plan can help control your diabetes. you should also monitor your glucose level and take medicine if prescribed. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diabetes Mellitus, also known as diabetes, is related to gestational diabetes and insulin resistance. An important gene associated with Diabetes Mellitus is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Type II diabetes mellitus and Regulation of beta-cell development. The drug chromium picolinate and the compounds glucose and arginine have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and mortality/aging.

CDC:3 CDC's Division of Diabetes Translation translates diabetes research into daily practice to understand the impact of the disease, influence health outcomes, and improve access to quality health care.

Novus Biologicals:46 Diabetes is a disease in which the body does not produce or properly use insulin. There are four major types of diabetes: Type 1, Type 2, Gestational and Pre-Diabetes. Type 1 diabetes, previously known as juvenile diabetes, is an autoimmune disease resulting when one's own immune system destroys insulin-producing beta cells in the pancreas. This causes the pancreas to produce little or no insulin. In type 2 diabetes, the body either does not produce enough insulin or beta cells ignore insulin. Gestational diabetes refers to high glucose levels caused by pregnancy. Pre-diabetes is a condition in which blood glucose levels are high, but not high enough for the diagnosis of type 2 diabetes.

Wikipedia:64 Diabetes mellitus, or simply diabetes, is a group of metabolic diseases in which a person has high blood... more...

Description from OMIM:47 222100

Aliases & Classifications for Diabetes Mellitus

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 47OMIM, 34MedlinePlus, 40NCIt, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine
ICD10: 25



Aliases & Descriptions:

diabetes mellitus 8 10 45 61
diabetes 8 47 34 61
diabetes nos 8


Related Diseases for Diabetes Mellitus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the type 2 diabetes mellitus family:

type 1 diabetes mellitus diabetes mellitus

Diseases related to Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1437)
idRelated DiseaseScoreTop Affiliating Genes
1gestational diabetes32.0PTPRN, SLC2A4, ABCC8, LEP, IAPP, CAPN10
2insulin resistance31.7SLC2A4, ABCC8, LEP, IL6, IAPP, CAPN10
3neonatal diabetes mellitus31.7PLAGL1, ABCC8, PDX1, HNF1B, GCK, KCNJ11
4type 1 diabetes31.4PTPRN, CTLA4, GCK
5diabetes mellitus, noninsulin-dependent31.3HNF1B, NEUROD1, ABCC8, SLC2A4
6atherosclerosis31.3LEP, IL6, AKR1B1, CAPN10
7type 2 diabetes mellitus31.3SLC2A4, HNF1B
8permanent neonatal diabetes mellitus31.2ABCC8, KCNJ11
9hypoglycemia31.2AKR1B1, GCK, KCNJ11, IAPP, SLC2A2, SLC2A4
10celiac disease31.1CTLA4
11thyroiditis31.0CTLA4
12glucose intolerance31.0KCNJ11, GCK, SLC2A2, SLC2A4, ABCC8, LEP
13hypercholesterolemia30.9PDX1, CAPN10
14hypertriglyceridemia30.8LEP, SLC2A4
15polycystic ovary syndrome30.8CAPN10, LEP, SLC2A4
16hyperinsulinism30.7KCNJ11, GCK, LEP, ABCC8
17insulinoma30.7PTPRN, SLC2A2, ABCC8, IAPP, WFS1, PDX1
18morbid obesity30.6LEP
19proliferative diabetic retinopathy30.6HGF
20cystic fibrosis30.6KCNJ11, CAPN10, ABCC8
21pancreatic agenesis30.6PDX1
22acute pancreatitis30.5IAPP, IL6
23hyperandrogenism30.4LEP, CAPN10
24growth hormone deficiency30.4LEP
25hyperinsulinemic hypoglycemia30.3ABCC8, GCK, KCNJ11
26adenoma30.3PLAGL1, CTLA4
27hyperuricemia30.3GCK, HNF1B
28adenocarcinoma30.1HNF1B, HGF, PDX1, NEUROD1, IAPP, SLC2A4
29maturity-onset diabetes of the young30.1KCNJ11, GCK, HNF1B, PDX1, NEUROD1
30vitiligo30.1CTLA4
31pheochromocytoma30.0IAPP
32beckwith-wiedemann syndrome29.9ZFP57, ABCC8, PLAGL1
33blindness29.9AKR1B1
34metabolic syndrome x29.8SLC2A4, LEP
35pulmonary disease, chronic obstructive29.8IL6
36pituitary tumors29.6PLAGL1
37familial hyperinsulinism29.4KCNJ11, GCK, ABCC8
38primary hyperoxaluria29.4IL6
39nephrogenic diabetes insipidus11.0
40diabetic nephropathy10.9
41type 1 diabetes mellitus10.9
42coronary artery disease,10.9
43transient neonatal diabetes mellitus10.9
44autonomic neuropathy10.9
45coronary heart disease10.8
46n syndrome10.8
47diabetes, type 210.8
48vascular disease10.7
49diabetes, permanent neonatal10.7
50diabetic ketoacidosis10.7

Graphical network of the top 20 diseases related to Diabetes Mellitus:



Diseases related to diabetes mellitus

Clinical Features for Diabetes Mellitus

Sources:
47OMIM
See all sources

Clinical features from OMIM:

222100

Drugs & Therapeutics for Diabetes Mellitus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diabetes Mellitus

Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus

Search NIH Clinical Center for Diabetes Mellitus

Search CenterWatch for Diabetes Mellitus

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Diabetes Mellitus

Anatomical Context for Diabetes Mellitus

Animal Models for Diabetes Mellitus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Diabetes Mellitus

Sources:
51PubMed
See all sources

Articles related to Diabetes Mellitus:

(show top 50)    (show all 7775)
idTitleAuthorsYear
1
Role of insulin and adenosine in the human placenta microvascular and macrovascular endothelial cell dysfunction in gestational diabetes mellitus. (23875992)
2014
2
Screening for Gestational Diabetes Mellitus: U.S. Preventive Services Task Force Recommendation Statement. (24424622)
2014
3
Palpebral ptosis, fixed mydriasis and exophthalmos: an uncommon presentation of new diabetes mellitus. (22907808)
2013
4
Expression and DNA methylation status of microRNA-375 in patients with type 2 diabetes mellitus. (24366165)
2013
5
Association between periodontitis and gestational diabetes mellitus: a case-control study. (23106510)
2013
6
Redefinition of gestational diabetes mellitus: implications for laboratory practice in Croatia. (23457760)
2013
7
Retrogression of Nervous Fibers According to the Age of Patients with Diabetes Mellitus (DM). (24259916)
2013
8
Association of polymorphism of ser311cys paraoxonase-2 gene with type 2 diabetes mellitus in iran. (23930161)
2013
9
Ambulatory Treatment of Type 2 Diabetes Mellitus in the United States, 1997-2012. (24198301)
2013
10
Low dose spironolactone reduces blood pressure in patients with resistant hypertension and type 2 diabetes mellitus: a double blind randomized clinical trial. (24107738)
2013
11
Differences in circadian time structure of diastolic blood pressure between diabetes mellitus and essential hypertension. (23245213)
2012
12
Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus. (22591707)
2012
13
Predictors of glycemic control in children with Type 1 diabetes mellitus in Assiut-Egypt. (23087867)
2012
14
Trace elements and cell-mediated immunity in gestational and pre-gestational diabetes mellitus at third trimester of pregnancy. (23331392)
2012
15
Dehydroepiandrosterone prevents the aggregation of platelets obtained from postmenopausal women with type 2 diabetes mellitus through the activation of the PKC/eNOS/NO pathway. (22517552)
2012
16
Behaviour and metabolic control in children with Type 1 diabetes mellitus on insulin pump therapy: 2-year follow-up. (21843306)
2011
17
Opioid receptor blockade improves hypoglycemia-associated autonomic failure in type 1 diabetes mellitus. (21917871)
2011
18
Type 2 diabetes mellitus is characterized by reduced postprandial adiponectin response: a possible link with diabetic postprandial dyslipidemia. (19922965)
2010
19
Common polymorphisms of the peroxisome proliferator-activated receptor-gamma (Pro12Ala) and peroxisome proliferator-activated receptor-gamma coactivator-1 (Gly482Ser) and the response to pioglitazone in Chinese patients with type 2 diabetes mellitus. (20045142)
2010
20
Association of moderate and severe hypertriglyceridemia with obesity, diabetes mellitus and vascular disease in the Spanish working population: results of the ICARIA study. (19545869)
2009
21
Gene polymorphisms of TNF-alpha-308 (G/A), IL-10(-1082) (G/A), IL-6(-174) (G/C) and IL-1Ra (VNTR) in Egyptian cases with type 1 diabetes mellitus. (19127455)
2009
22
Comment on "Spontaneous autoimmunity sufficiently potent to induce diabetes mellitus is insufficient to protect against insulinoma". (19726765)
2009
23
Variable phenotypic spectrum of diabetes mellitus in a family carrying a novel KCNJ11 gene mutation. (18544102)
2008
24
Cardiovascular disease in type 1 diabetes mellitus]. (18438550)
2008
25
Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. (17496732)
2007
26
Dipeptidyl peptidase-4 inhibitors and the management of type 2 diabetes mellitus. (17940427)
2007
27
Modulation of cyclic nucleotides and cyclic nucleotide phosphodiesterases in pancreatic islet beta-cells and intestinal L-cells as targets for treating diabetes mellitus. (17086934)
2006
28
Management of diabetes mellitus in hospitalized patients: efficiency and effectiveness of sliding-scale insulin therapy. (16999652)
2006
29
Efficacy and safety of a mixture of two different brands of insulin products in patients with type 1 diabetes mellitus. (16323395)
2005
30
Type 2 diabetes mellitus complicated with smoldering myeloma and non-alcoholic steatohepatitis. (16157983)
2005
31
The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus. (15221640)
2004
32
The potential role of peroxisome proliferator-activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis. (12957325)
2003
33
Assessing cardiovascular autonomic neuropathy in diabetes mellitus: how many tests to use? (10925060)
2000
34
Specific activity of alpha1proteinase inhibitor and alpha2macroglobulin in human serum: application to insulin-dependent diabetes mellitus. (9837695)
1998
35
A missense mutation in hepatocyte nuclear factor-4-alpha, resulting in a reduced transactivation activity, in human late-onset non- insulin-dependent diabetes mellitus. (9449683)
1998
36
Effect of sugar-reducing therapy on renal function in patients with type II diabetes mellitus]. (9693499)
1998
37
Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group. (9435304)
1998
38
ACE inhibitors in patients with diabetes mellitus. Clinical and economic considerations. (10160252)
1996
39
The prevention of insulin-dependent diabetes mellitus]. (9254534)
1996
40
Analysis of the insulin receptor gene in noninsulin-dependent diabetes mellitus by denaturing gradient gel blots: a clinical research center study. (7775636)
1995
41
Gestational diabetes mellitus and paradoxical fetal macrosomia--a case report. (7635072)
1995
42
Lp(a) serum concentrations in diabetes mellitus]. (7869592)
1994
43
Insulin-like growth factors and binding proteins in patients with recent-onset type 1 (insulin-dependent) diabetes mellitus: influence of diabetes control and intraportal insulin infusion. (7530621)
1994
44
Effect of a sulfonylurea (gliclazide) treatment on insulin sensitivity and glucose-mediated glucose disposal in patients with non-insulin-dependent diabetes mellitus (NIDDM). (8375268)
1993
45
Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity. (1999488)
1991
46
Prevalence of thyroid autoimmunity in insulin dependent diabetes mellitus in the Bayamon region. (2043229)
1991
47
Variation in the apolipoprotein B gene and development of type 2 diabetes mellitus. (1685948)
1991
48
The determination of specific proteins in the biological fluids from pregnant women suffering from diabetes mellitus]. (1862849)
1991
49
Perforating granuloma annulare and diabetes mellitus. (2397977)
1990
50
Neurogenic arthropathy due to diabetes mellitus. (5567123)
1971

Genetic Variations for Diabetes Mellitus

Expression for genes affiliated with Diabetes Mellitus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus

Search GEO for disease gene expression data for Diabetes Mellitus.

Pathways for genes affiliated with Diabetes Mellitus

Sources:
30KEGG, 38NCBI BioSystems Database, 50PharmGKB, 54Reactome, 52QIAGEN, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9SLC2A2, KCNJ11, GCK, HNF1B, PDX1, NEUROD1
2
Hide members
11.6GCK, HNF1B, PDX1, NEUROD1, IAPP, SLC2A2
311.4KCNJ11, GCK, PDX1, ABCC8, SLC2A2
411.4KCNJ11, GCK, PDX1, ABCC8, SLC2A2
5
Hide members
11.4IAPP, NEUROD1, PDX1, HNF1B, GCK
6
Hide members
11.4HGF, IL6, SLC2A4, SLC2A2, PTPRN
7
Development Leptin signaling via PI3K-dependent pathway
Hide members
11.2KCNJ11, LEP, ABCC8, SLC2A4
811.2SLC2A2, IAPP, PDX1, HNF1B
911.2SLC2A4, WFS1, NEUROD1, PDX1
10
Hide members
11.0SLC2A2, ABCC8, KCNJ11
11
Hide members
11.0SLC2A2, SLC2A4, GCK
12
Hide members
11.0GCK, SLC2A4, SLC2A2
1310.8KCNJ11, ABCC8
1410.8SLC2A2, SLC2A4

Compounds for genes affiliated with Diabetes Mellitus

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1glucose4513.7PTPRN, GCK, KCNJ11, HNF1B, CAPN10, PDX1
2arginine4512.9KCNJ11, GCK, HNF1B, HGF, CAPN10, AKR1B1
3calcium45 50 11 2415.6KCNJ11, GCK, HGF, CAPN10, PDX1, CTLA4
4lipid4512.5GCK, HGF, CAPN10, CTLA4, IAPP, IL6
5serine4512.4GCK, HGF, PDX1, CTLA4, AKR1B1, IAPP
6testosterone45 60 11 2415.4HGF, AKR1B1, IAPP, IL6, LEP, ABCC8
7cholesterol45 29 11 2415.4GCK, HNF1B, CAPN10, CTLA4, IAPP, IL6
8glutamate4512.3KCNJ11, GCK, HGF, ICA1, CTLA4, LEP
9sulfonylurea4512.2SLC2A2, SLC2A4, ABCC8, IAPP, PDX1, GCK
10c-peptide4512.2KCNJ11, GCK, PDX1, IAPP, LEP, SLC2A2
11glycogen45 2413.2GCK, HGF, CAPN10, IAPP, ABCC8, SLC2A4
12creatinine4512.2GCK, HGF, AKR1B1, IAPP, IL6, LEP
13h2o24512.1GCK, HGF, AKR1B1, IAPP, LEP, SLC2A4
14dexamethasone45 50 29 1115.1GCK, HGF, CTLA4, IAPP, IL6, LEP
15streptozotocin4512.0GCK, PDX1, AKR1B1, IAPP, SLC2A4, SLC2A2
16metformin45 50 1114.0KCNJ11, GCK, IAPP, LEP, ABCC8, SLC2A4
17retinoic acid45 2413.0GCK, HNF1B, HGF, PDX1, NEUROD1, IL6
18indomethacin45 60 29 1115.0HGF, AKR1B1, IAPP, IL6, LEP, SLC2A4
19ly2940024512.0GCK, HGF, CTLA4, IL6, LEP, SLC2A4
20cysteine4512.0GCK, CAPN10, CTLA4, AKR1B1, IAPP, LEP
21potassium45 11 2413.9KCNJ11, GCK, HGF, CAPN10, ABCC8, SLC2A2
22cyclosporin a45 29 6013.9HGF, CTLA4, AKR1B1, IL6, LEP, PTPRN
23lactate4511.9GCK, HGF, AKR1B1, IAPP, IL6, SLC2A4
24katp4511.8KCNJ11, GCK, PDX1, ABCC8, SLC2A2
25glibenclamide45 29 50 6014.8KCNJ11, IAPP, LEP, ABCC8, SLC2A4
26pyruvate4511.7GCK, HGF, PDX1, SLC2A4, SLC2A2
27n acetylcysteine4511.7HGF, PDX1, AKR1B1, IL6, LEP
28incretin4511.6GCK, PDX1, IAPP, SLC2A2
29repaglinide45 50 1113.6ABCC8, IAPP, NEUROD1, KCNJ11
30wortmannin4511.6HGF, PDX1, CTLA4, LEP, SLC2A4
31nicotinamide45 1112.6HNF1B, HGF, PDX1, AKR1B1
32fructose45 1112.6GCK, AKR1B1, SLC2A4, SLC2A2
333-o-methylglucose4511.4GCK, SLC2A4, SLC2A2
34preproinsulin4511.4SLC2A2, PDX1, GCK
35i-app4511.4IAPP, PDX1, GCK
36fatty acid4511.4SLC2A4, ABCC8, LEP, HGF, GCK
37proglucagon4511.4SLC2A2, PDX1, GCK
38glimepiride45 50 1113.3KCNJ11, ABCC8, SLC2A4
39gliclazide45 50 1113.3SLC2A4, ABCC8, KCNJ11
40diazoxide45 60 29 1114.3ABCC8, GCK, KCNJ11
41tolbutamide45 50 29 1114.2KCNJ11, GCK, ABCC8
42cibenzoline4511.1KCNJ11, ABCC8
43aicar45 11 2413.1GCK, LEP, SLC2A4
44norepinephrine45 11 2413.1SLC2A4
45minoxidil45 29 1113.0ABCC8
46alloxan4511.0SLC2A2, GCK
47[3h]2-deoxyglucose2911.0SLC2A2, SLC2A4
48glycerol45 11 2412.9GCK, AKR1B1, LEP, SLC2A4
49forskolin45 50 1112.8SLC2A2, PDX1
50abatacept45 1111.7IL6, CTLA4

GO Terms for genes affiliated with Diabetes Mellitus

Sources:
16Gene Ontology
See all sources

Biological processes related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1endocrine pancreas developmentGO:03101812.1SLC2A2, GCK, HNF1B, PDX1, NEUROD1, IAPP
2regulation of insulin secretionGO:05079611.9KCNJ11, GCK, NEUROD1, LEP, ABCC8, SLC2A2
3positive regulation of transcription from RNA polymerase II promoterGO:04594411.8HNF1B, HGF, PDX1, NEUROD1, IL6, PLAGL1
4glucose homeostasisGO:04259311.7GCK, PDX1, NEUROD1, WFS1, SLC2A4
5carbohydrate metabolic processGO:00597511.7GCK, AKR1B1, ABCC8, SLC2A4, SLC2A2
6insulin secretionGO:03007311.5HNF1B, PDX1, NEUROD1, LEP
7energy reserve metabolic processGO:00611211.5KCNJ11, LEP, ABCC8, SLC2A2
8positive regulation of insulin secretionGO:03202411.3PDX1, CAPN10, GCK
9hexose transportGO:00864511.3GCK, SLC2A4, SLC2A2
10response to insulin stimulusGO:03286811.3PTPRN, LEP, IL6
11cellular response to insulin stimulusGO:03286911.2GCK, CAPN10, SLC2A4
12positive regulation of apoptotic processGO:04306511.2CAPN10, CTLA4, NEUROD1, IL6
13response to glucose stimulusGO:00974911.2PTPRN, NEUROD1, HNF1B
14glucose transportGO:01575811.2GCK, SLC2A4, SLC2A2
15detection of glucoseGO:05159411.1PDX1, GCK
16positive regulation of STAT protein import into nucleusGO:200036611.1LEP, IL6
17response to drugGO:04249311.1KCNJ11, PDX1, NEUROD1, IL6
18negative regulation of type B pancreatic cell apoptotic processGO:200067511.1WFS1, NEUROD1
19negative regulation of gluconeogenesisGO:04572111.0IL6, GCK
20neurological system processGO:05087710.9WFS1, KCNJ11
21nitric oxide mediated signal transductionGO:00726310.8NEUROD1, PDX1
22glucose metabolic processGO:00600610.7LEP, PDX1, KCNJ11

Molecular functions related to Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1D-glucose transmembrane transporter activityGO:05505610.8SLC2A2, SLC2A4

Products for genes affiliated with Diabetes Mellitus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetes Mellitus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet