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Diabetes Mellitus malady
1 drug, 910 genes, 38 tissues, 1259 related diseases, 29 phenotypes, 4554 articles, clinical trials.

Summaries for Diabetes Mellitus

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23MedlinePlus, 2CDC, 44Wikipedia, 22MalaCards
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MedlinePlus: Diabetes is a disease in which your blood glucose, or sugar, levels are too high. glucose comes from the foods you eat. insulin is a hormone that helps the glucose get into your cells to give them energy. with type 1 diabetes, your body does not make insulin. with type 2 diabetes, the more common type, your body does not make or use insulin well. without enough insulin, the glucose stays in your blood. over time, having too much glucose in your blood can cause serious problems. it can damage your eyes, kidneys, and nerves. diabetes can also cause heart disease, stroke and even the need to remove a limb. pregnant women can also get diabetes, called gestational diabetes. a blood test can show if you have diabetes. exercise, weight control and sticking to your meal plan can help control your diabetes. you should also monitor your glucose level and take medicine if prescribed. nih: national institute of diabetes and digestive and kidney diseases23

MalaCards: Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and carcinoma. An important gene associated with Diabetes Mellitus is TNDM (diabetes mellitus, transient neonatal), and among its related pathways are cAMP Pathway and Molecular Mechanisms of Cancer. The drug chromium picolinate and the compounds estrogen and serine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are hearing/vestibular/ear and growth/size.

CDC: CDC's Division of Diabetes Translation translates diabetes research into daily practice to understand the impact of the disease, influence health outcomes, and improve access to quality health care.2

Wikipedia: Diabetes mellitus, or simply diabetes, is a group of metabolic diseases in which a person has high blood...44 more...

Aliases & Descriptions for Diabetes Mellitus

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2CDC, 6Disease Ontology, 7diseasecard, 8DISEASES, 32Novoseek , 43UMLS, 17Genetics Home Reference, 23MedlinePlus, 40SNOMED-CT, 24MeSH, 19ICD9CM, 27NCIt
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Aliases & Descriptions:

diabetes mellitus 6 7 8 32 43
diabetes 6 7 17 23 43
diabetes mellitus (disorder) 6
diabetes nos 6

External Ids:

ICD9CM19 250
SNOMED-CT40 191044006, 267467004, 154671004 73211009, more
NCIt27 C2985

Related Diseases for Diabetes Mellitus

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13GeneCards, 14GeneDecks
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Disease types for type 1 diabetes mellitus family:

diabetes mellitus type 2 diabetes mellitus

Diseases related to diabetes mellitus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1255)
idRelated DiseaseScoreTop Affiliating Genes
1type 2 diabetes mellitus135.6PIK3R1, PIK3C2A, LRP5, LRP6, COG2, PDE3B
2carcinoma125.8ZNF673, PIK3R1, PIK3C2A, PIK3CG, LRP5, LRP6
3pancreatitis121.0PIK3R1, PIK3C2A, PIK3CG, LRP5, PDCD1LG2, PDE3B
4obesity118.2PIK3R1, PIK3C2A, PIK3CG, WDPCP, LRP5, COG2
5prostatitis110.3ZNF673, PIK3R1, PIK3C2A, PIK3CG, LRP5, PDCD1
6hypertension106.6PIK3R1, PIK3C2A, PIK3CG, WDPCP, LRP5, LRP6
7cholesterol105.4PIK3R1, PIK3C2A, PIK3CG, LRP5, LRP6, COG2
8thyroiditis103.7PIK3R1, PIK3C2A, PIK3CG, COG2, RECK, REN
9leukemia103.4ZNF673, PIK3R1, PIK3C2A, PIK3CG, LRP5, LRP6
10insulin resistance103.3PIK3R1, PIK3CG, COG2, PDE3B, REN, RETN
11atherosclerosis103.2ZNF673, PIK3C2A, PIK3CG, LRP5, LRP6, COG2
12neuronitis102.5PIK3R1, PIK3C2A, PIK3CG, LRP6, PDE3B, RECK
13arthritis99.1PIK3CG, LRP5, SH2B3, PDCD1, PDCD1LG2, RECK
14nephropathy97.3COG2, PDCD1, REG1A, REN, RETN, CNDP1
15rheumatoid arthritis93.6PIK3CG, LRP5, SH2B3, PDCD1, PDCD1LG2, RECK
16myocardial infarction91.7PIK3C2A, PIK3CG, SH2B3, COG2, PDCD1, RECK
17alzheimer's disease89.3PIK3R1, PIK3CG, LRP6, COG2, RECK, REG1A
18cerebritis88.3PIK3R1, PIK3C2A, PIK3CG, LRP6, COG2, REG1A
19hepatocellular carcinoma88.1PIK3R1, PIK3CG, PDCD1, PDCD1LG2, RECK, REG1A
20fibrosis87.1PIK3CG, RECK, REG1A, REN, RETN, CNR1
21ischemia82.8PIK3C2A, PIK3CG, COG2, REN, RETN, CNR1
22coronary heart disease82.7PIK3C2A, LRP5, COG2, RETN, CNDP1, VWF
23hyperglycemia81.0PIK3R1, PIK3C2A, PIK3CG, SH2B3, COG2, RETN
24ovarian cancer78.6ZNF673, PIK3R1, PIK3CG, PDCD1, RECK, VWF
25retinitis78.1PIK3C2A, PIK3CG, LRP5, PDE3B, CNR1, CNR2
26lupus erythematosus78.0PIK3C2A, PIK3CG, SH2B3, COG2, PDCD1, PDCD1LG2
27hypoxia75.5PIK3R1, PIK3C2A, PIK3CG, LRP5, RECK, REN
28type 1 diabetes mellitus75.1PIK3CG, LRP5, PDCD1, RETN, KIR3DL1, GCK
29blindness74.1PIK3C2A, PIK3CG, LRP5, COG2, REN, CNR1
30schizophrenia74.0PIK3R1, PIK3CG, RET, CNDP1, CNR1, CNR2
31anemia72.4PDCD1, REN, VWF, GCLC, SELE, SELL
32tuberculosis72.3PIK3CG, PDCD1, PDCD1LG2, PDE3B, CNDP1, CNDP2
33peritonitis71.2PIK3C2A, COG2, PDE3B, REG1A, REN, RET
34acute myocardial infarction70.3PIK3C2A, PIK3CG, COG2, REN, RETN, VWF
35adenoma70.1RECK, REG1A, REG1B, REN, RET, RETN
36colon cancer69.6PIK3R1, PIK3CG, LRP6, RECK, REG1A, RETN
37inflammatory bowel disease69.3RETN, VWF, GCG, GC, RBP4, SELE
38essential hypertension69.2COG2, REN, RETN, VWF, GCK, GCGR
39cystic fibrosis69.0PIK3CG, RECK, REG1A, REN, VWF, GCLC
40dementia67.1PIK3C2A, PIK3CG, VWF, GCKR, SELP, SERPINC1
41neuropathy66.3ZNF673, PIK3C2A, PDE3B, REN, RETN, CNR1
42psoriasis66.0RETN, CNR1, KIR2DS5, KIR3DS1, KIR3DL1, KIR2DS2
43myeloma65.7PIK3R1, PIK3CG, LRP5, LRP6, RECK, KIR3DS1
44homocysteine65.3PIK3R1, PIK3C2A, COG2, REN, RETN, VWF
45diabetic retinopathy64.8PIK3CG, CNR1, VWF, RBP4, SELE, SELL
46pulmonary disease64.7PIK3CG, LRP5, LRP6, REN, RET, RETN
47pneumonia64.6PIK3C2A, COG2, CNDP1, CNDP2, RBP4, SELE
48twinning64.5PIK3R1, COG2, REN, RETN, VWF, RDH5
49hypercholesterolemia62.3PIK3C2A, COG2, RETN, VWF, GCG, RBP4
50graves' disease61.5PDCD1, PDCD1LG2, RETN, KIR2DS5, KIR3DS1, KIR3DL1

Graphical network of the top 20 diseases related to diabetes mellitus:



Graphical network of diseases related to diabetes mellitus

Clinical Features for Diabetes Mellitus

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Drugs & Therapeutics for Diabetes Mellitus

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for diabetes mellitus

Drug clinical trials:

Search ClinicalTrials for diabetes mellitus

Search NIH Clinical Center for diabetes mellitus

Search CenterWatch for diabetes mellitus

Inferred drug relations via UMLS/NDF-RT:

43 28 chromium picolinate

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for diabetes mellitus:
Bone marrow derived adult mesenchymal stem cells for the treatment of type I diabetes
Umbilical cord derived mesenchymal stem cells for treatment of type I diabetes

Genetic Tests for Diabetes Mellitus

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Anatomical Context for Diabetes Mellitus

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22MalaCards
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MalaCards organs/tissues related to diabetes mellitus:

22
Bone marrow, Whole blood, Lymph node, Spleen, Thymus, Brain, Retina, Spinal cord, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Kidney, Liver, Lung, Pancreas, Thyroid, Breast, Skin, Ovary, Placenta, Prostate, Testis, Monocytes, T cells, B cells, Endothelial, Fetal brain, Hypothalamus, Pons, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Pituitary, Testis leydig

Phenotypes for genes affiliated with Diabetes Mellitus

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25MGI
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MGI Mouse Phenotypes related to diabetes mellitus:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hearing/vestibular/ear phenotypeMP:0005377INFLRP6, NAGLU, VDR, , MYO5A, BMP2
2growth/size phenotypeMP:0005378INFPIK3R1, PIK3C2A, PIK3CG, LRP6, PDE3B, RECK
3limbs/digits/tail phenotypeMP:0005371INFLRP5, LRP6, RECK, RET, , VEGFA
4other phenotypeMP:0005395INFSH2B3, RECK, CNR1, CLU, ZFP57, PBX1
5hematopoietic system phenotypeMP:0005397INFSH2B3, PDCD1, PDCD1LG2, PCSK1, BTLA, BSCL2
6homeostasis/metabolism phenotypeMP:0005376INFPIK3R1, PIK3C2A, PIK3CG, LRP5, LRP6, PDCD1LG2
7renal/urinary system phenotypeMP:0005367INFLRP6, PDCD1, REN, RET, PCBD1, GCK
8craniofacial phenotypeMP:0005382INFLRP5, LRP6, NAGLU, , MYO5A, BMP4
9behavior/neurological phenotypeMP:0005386INFLRP5, LRP6, REG1B, REN, CNR1, PCSK1
10endocrine/exocrine gland phenotypeMP:0005379INFLRP5, REG1A, RET, PCSK1, SELL, SEL1L
11reproductive system phenotypeMP:0005389INFLRP6, REG1A, REN, RET, PCSK1, GCGR
12respiratory system phenotypeMP:0005388INFLRP6, RET, SELL, SELP, LPL,
13no phenotypic analysisMP:0003012INFPIK3R1, LRP6, PDCD1LG2, RET, CNR1,
14normal phenotypeMP:0002873INFPIK3R1, LRP5, LRP6, REN, RET, PCK1
15adipose tissue phenotypeMP:0005375INFPIK3R1, PIK3C2A, LRP6, PDE3B, RETN, CNR1
16integument phenotypeMP:0010771INFPIK3CG, LRP6, PDE3B, RECK, CNR1, CNR2
17embryogenesis phenotypeMP:0005380INFLRP5, LRP6, RECK, RET, , GCLC
18digestive/alimentary phenotypeMP:0005381INFLRP6, RET, VWF, PCSK1, GCG, BSCL2
19mortality/agingMP:0010768INFPIK3C2A, LRP5, LRP6, PDCD1, PDCD1LG2, RECK
20immune system phenotypeMP:0005387INFLRP5, REN, CNR2, VWF, PCSK1, BTLA
21vision/eye phenotypeMP:0005391INFLRP5, LRP6, PDCD1, , RDH5, PCBD1
22cellular phenotypeMP:0005384INFPIK3R1, PIK3CG, LRP5, LRP6, SH2B3, PDCD1
23tumorigenesisMP:0002006INFPIK3R1, PDCD1LG2, RET, SELL, SERPINE1, PAX6
24nervous system phenotypeMP:0003631INFLRP5, LRP6, PDCD1, RECK, REG1B, REN
25cardiovascular system phenotypeMP:0005385INFPIK3R1, PIK3CG, LRP5, PDCD1, RECK, REN
26liver/biliary system phenotypeMP:0005370INFLRP5, LRP6, RECK, REG1B, RETN, PCK1
27muscle phenotypeMP:0005369INFPIK3R1, PIK3CG, PDCD1, REN, RET, PCSK1
28pigmentation phenotypeMP:0001186INFLRP5, PDE3B, PCBD1, BTD, SERPINC1, NAGLU
29skeleton phenotypeMP:0005390INFPIK3CG, LRP6, RECK, CNR1, , GC

Publications for genes affiliated with Diabetes Mellitus

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35PubMed
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Articles related to diabetes mellitus:

(show top 50)    (show all 4554)
idTitleAuthorsYearAffiliating Genes
1The presence of the peptides apelin, ghrelin and nesf atin-1 in the human breast milk, and the lowering of their levels in patients w ith gestational diabetes mellitus. (20813143)Aydin S.2010GHRL, NUCB2, APLN
2Retinol-binding protein-4 is associated with endothelial dysfunction in adults with newly diagnosed type 2 diabetes mellitus. (18838136)Park S.E.... Cha B.S.2009RBP4
3Multiple drug resistance associated with function of ABC-transporters in diabetes mellitus: molecular mechanism and clinical relevance. (18537706)Koehn J.... Krapfenbauer K.2008ABCA1
4A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients. (17934151)Kang E.S.... Lee H.C.2008TCF7L2
5Liraglutide: a once-daily GLP-1 analogue for the treatment of type 2 diabetes mellitus. (17243943)VilsbA... ll T.2007GLP1R, GCG
6HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children. (17341285)Rodriguez-Ventura A.L.... Granados J.2007HLA-DRB1
7Progressive glycosylation of albumin and its effect on the binding of homocysteine may be a key step in the pathogenesis of vascular damage in diabetes mellitus. (17224246)Mathai M.... Holland P.2007ALB
8Childhood diabetes mellitus: recent advances & future prospects. (17496353)Dejkhamron P.... Sperling M.A.2007INS
9Hepatic safety profile and glycemic control of pioglitazone in more than 20,000 patients with type 2 diabetes mellitus: postmarketing surveillance study in Japan. (17109986)Kawamori R.... Akanuma Y.2007GPT
10Autoimmune diabetes mellitus with adult onset and type 1 diabetes mellitus in children have different genetic predispositions. (17911429)Cerna M.... Andel M.2007INS
11Time course of C-reactive protein reduction with simvastatin therapy in patients with type 2 diabetes mellitus. (17145229)Hernandez T.L.... Eckel R.H.2006CRP
12Variation of mitochondrial gene and the association with type 2 diabetes mellitus in a Chinese population. (16414144)Tang D.L.... Liu F.2006MT-ND1, MT-TL1, MT-RNR1
13The Arg121Trp variant in PAX4 gene is associated with beta-cell dysfunction in Japanese subjects with type 2 diabetes mellitus. (16423628)Tokuyama Y.... Kanatsuka A.2006PAX4
14Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children. (16390391)Ohtsu S.... Matsuura N.2005HLA-DQA1, HLA-DQB1, HLA-DRB1
15Genetic polymorphisms in peroxisome proliferator-activated receptor gamma are associated with Type 2 diabetes mellitus and obesity in the Korean population. (16108843)Moon M.K.... Shin H.D.2005PPARG
16A role of vitamin D in low-intensity chronic inflammation and insulin resistance in type 2 diabetes mellitus? (19079903)Flores M.2005TNF, IL6, INS
17PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction. (15654230)Li J.... Xu X.2005PON1
18Diabetes mellitus in elderly: geroprotective and ant idiabetic properties of delta-sleep induced peptide (15754961)Odin V.I.... Barr N.A.2004INS
19Anti-GAD-positive patients with type 1 diabetes mellitus have higher prevalence of autoimmune thyroiditis than anti-GAD-negative patients with type 1 and type 2 diabetes mellitus. (15209535)BA!rovA! H.... Masek Z.2004TPO
20Effect of long-term antihypertensive therapy on vaso -regulating function of the brachial artery in patients with arterial hypertens ion associated with type 2 diabetes mellitus (14708444)Karpov R.S.... Makarova E.V.2003ACE
21Increased plasma urotensin II levels in patients with diabetes mellitus. (12519081)Totsune K.... Murakami O.2003UTS2
22Transient neonatal diabetes mellitus, type 4, type 1 diabetes mellitus, or MODY: which disease is it, anyway? (12014522)AvRuskin T.W.... Juan C.S.2002TPO
23Identification of a novel mutation in the GLUT2 gene in a patient with Fanconi-Bickel syndrome presenting with neonatal diabetes mellitus and galactosaemia. (12029458)Yoo H.W.... Kim G.H.2002F2, SLC2A2
24Autoantibodies to tissue transglutaminase in patients from eastern India with malnutrition-modulated diabetes mellitus, insulin-dependent diabetes mellitus, and non-insulin-dependent diabetes mellitus. (12021113)Kanungo A.... Sanjeevi C.B.2002INS, PTPN3
25Evidence for mechanistic alterations of Ca2+ homeosta sis in Type 2 diabetes mellitus. (11467418)Balasubramanyam M.... Mohan V.2001DNAH8
26Treatment of type 2 diabetes mellitus in children and adolescents. (11202216)Silverstein J.H.... Rosenbloom A.L.2000INS
27Relative hypoleptinaemia in women with mild gestational diabetes mellitus. (10477210)Festa A.... Haffner S.M.1999LEP
28Changes in superoxide dismutase activities and concentrations and myeloperoxidase activities in leukocytes from patients with diabetes mellitus. (10765000)Uchimura K.... Itoh M.1999SOD1, MPO
29Tumor necrosis factor-alpha: a continuum of liability between insulin-dependent diabetes mellitus, non-insulin-dependent diabetes mellitus and carcinoma (review). (10465670)Holden R.J.... Mooney P.A.1999ACP1, INS
30Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY. (10588527)Ng M.C.Y.... Chan J.C.N.1999GCK, HNF1A
31The impact of a family history of Type II (non-insulin-dependent) diabetes mellitus on the risk of diabetic nephropathy in patients with Type I (insulin-dependent) diabetes mellitus. (10333042)Fagerudd J.A.... Groop P.H.1999INS
32Gestational diabetes mellitus and subsequent development of overt diabetes mellitus. (9850811)Damm P.1998INS
33Bone turnover and insulin-like growth factor I levels increase after improved glycemic control in noninsulin-dependent diabetes mellitus. (9685513)Rosato M.T.... Shapses S.A.1998IGF1
34Interleukin-1 beta induced transient diabetes mellitus in rats. A model of the initial events in the pathogenesis of insulin-dependent diabetes mellitus? (9587701)Reimers J.I.1998IL1B
35Insulin receptor substrate-1 gene variants in lipoatrophic diabetes mellitus and non-insulin-dependent diabetes mellitus: a study of South African black and white subjects. (9385382)Panz V.R.... Joffe B.I.1997IRS1
36Do non-insulin-dependent diabetes mellitus (NIDDM) an d insulin-dependent diabetes mellitus (IDDM) share genetic susceptibility loci? An analysis of putative IDDM susceptibility regions in familial NIDDM. (9005968)Elbein S.C.... Hasstedt S.1997INS
37Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. (9169397)Malmberg K.1997INS
38Increased circulating leptin concentrations in insulin-resistant first-degree relatives of patients with non-insulin-dependent diabetes mellitus: relationship to body composition and insulin sensitivity but not to family history of non-insulin-dependent diabetes mellitus. (9116912)Nyholm B.... Schmitz O.1997LEP, INS, LSL
39Altered circadian blood pressure rhythm and progression of diabetic nephropathy in non-insulin dependent diabetes mellitus subjects: an average three year follow-up study. (8763975)Nakano S.... Morimoto S.1996NPPA
40Plasma lipoprotein composition and cholesteryl ester transfer from high density lipoproteins to very low density and low density lipoproteins in patients with non-insulin-dependent diabetes mellitus. (8641118)Bhatnagar D.... Boulton A.J.1996LCAT
41Insulin response to oral glucose load is consistently decreased in established non-insulin-dependent diabetes mellitus: the usefulness of decreased early insulin response as a predictor of non-insulin-dependent diabetes mellitus. (8894494)Kosaka K.... Yoshinaga H.1996INS
42Glucose transport in cultured human skeletal muscle cells. Regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects. (8675652)Ciaraldi T.P.... Henry R.R.1995SLC2A1, SLC2A4, INS
43Relationship between insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus: beta-cell function, islet cell antibody, and haptoglobin in parents of IDDM patients. (7616845)Kajio H.... Kosaka K.1995HP
44Characterization of insulin-like growth factor-binding proteins produced by cultured fibroblasts from patients with noninsulin-dependent diabetes mellitus, insulin-dependent diabetes mellitus, or obesity. (7527414)Giannini S.... Fujita-Yamaguichi Y.1994IGFBP3
45Immunoenzymometric analysis for plasma von Willebrand factor degradation in diabetes mellitus using monoclonal antibodies recognizing protease-sensitive sites. (8070070)Katayama M.... Titani K.1994VWF
46Effects of contraceptive steroids on cardiovascular risk factors in women with insulin-dependent diabetes mellitus. (8059818)Petersen K.R.... Jespersen J.1994INS
47Risk of radiocontrast nephropathy in patients with an d without diabetes mellitus. (8127017)Weisberg L.S.... Kurnik B.R.1994NPPA
48Growth hormone and diabetes mellitus. A review of sixty-three years of medical research and a glimpse into the future? (8300053)SAPnksen P.H.... Jones R.H.1993IGF1
49Delayed activation of D-glucose transport in type II diabetes mellitus. (1490687)Zeuzem S.... Caspary W.F.1992INSR
50Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. (1570017)Vionnet N.... Passa P.1992GCK, MAP4K2

Expression for genes affiliated with Diabetes Mellitus

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus

Pathways for genes affiliated with Diabetes Mellitus

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36QIAGEN, 20KEGG, 10EMD Millipore, 41Thomson Reuters, 3Cell Signaling Technology, 38Reactome
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Pathways related to diabetes mellitus according to GeneDecks:

(show top 50)    (show all 149)
idPathwayScoreTop Affiliating Genes
1cAMP Pathway36INFPIK3R1, PDE3B, GCG, GCGR, BTC, BMP2
2Molecular Mechanisms of Cancer36INFPIK3R1, PIK3CG, LRP5, LRP6, BMP2, BMP4
3TGF-Beta Pathway36INFPIK3R1, BTC, BMP2, BMP4, BMP6, BMP7
4Influenza A20INFPIK3R1, PIK3CG, VDAC1, CIITA, IL12A, IL12B
5Tec Kinases Signaling36INFPIK3R1, BTC, BMP2, BMP4, BMP6, BMP7
6DHA Signaling36INFPIK3R1, BTC, BMP2, BMP4, BMP6, BMP7
7NFAT in Immune Response36INFPIK3R1, BTC, BMP2, BMP4, BMP6, BMP7
8Measles20INFPIK3R1, PIK3CG, CD28, CD3D, CDK4, IRAK1
9MAPK Family Pathway36INFPIK3R1, BTC, BMP2, BMP4, BMP6, BMP7
10p38 Signaling36INFBTC, BMP2, BMP4, BMP6, BMP7, UTS2
11Phagosome2015.3SCARB1, MPO, CD36, CD14, ITGA2, ITGAM
12Rheumatoid arthritis2014.8VEGFA, CD28, CD86, CD80, ITGAL, ITGB2
13MIF Mediated Glucocorticoid Regulation3614.3BMP2, BMP4, BMP6, BMP7, BCL2, BAX
14PEDF Induced Signaling3614.1BMP2, BMP4, BMP6, BMP7, BDNF, BCL2
15MIF Regulation of Innate Immune Cells3614.0BMP2, BMP4, BMP6, BMP7, BCL2, BAX
16Hematopoietic cell lineage2013.5CD36, CD3D, CD14, CD4, CD38, ITGA2
17Selected targets of GCR-alpha1013.4LPIN1, LEP, CHAT, UCP3, CGA, INS
18Intestinal immune network for IgA production2013.2CD28, CD86, CD40LG, CD80, CD40, IL10
19CDC42 Pathway3613.1MUSK, AXL, CD3D, ITGA2, ITGA2B, ITGAL
20Type II diabetes mellitus2012.8PIK3R1, GCK, KCNJ11, IRS1, IRS2, IRS4
21Transcription Role of VDR in regulation of genes involved in osteoporosis1012.8VDR, BGLAP, CGA, CDKN1C, AR, IL1A
22Transcription_Role of VDR in regulation of genes involved in osteoporosis4112.7VDR, BGLAP, CGA, CDKN1C, AR, IL1A
23RAR-Gamma-RXR-Alpha Degradation3612.7BMP2, BMP4, BMP7, CD80, IL12A, IL15
24Graft-versus-host disease2012.5KIR3DL1, KIR2DL2, CD28, CD86, CD80, IL1A
25Immune response IL-22 signaling pathway1012.2BCL2, CD28, CD86, CD4, IL12A, IL12B
26CTL Mediated Apoptosis3612.1CD3D, GZMB, CASP9, HLA-A, HLA-B, HLA-C
27Immune response_IL-22 signaling pathway4112.0BCL2, CD28, CD86, CD4, IL12A, IL12B
28Insulin signaling pathway20INFPIK3R1, PDE3B, PCK2, PCK1, GCK, LIPE
29Renin-Angiotensin Pathway36INFPIK3R1, REN, BTC, VCAM1, BMP2, BMP4
30NF-KappaB Family Pathway36INFPIK3R1, BTC, BMP2, BMP4, BMP6, BMP7
31Mitochondrial Apoptosis36INFPIK3R1, BTC, VDAC1, BMP2, BMP4, BMP6
32NF-KappaB (p50-p65) Pathway36INFPIK3R1, BTC, BMP2, BMP4, BMP6, BMP7
33Activation of PKA through GPCR36INFPDE3B, GCG, GCGR, BTC, BMP2, BMP4
34PAK Pathway36INFPIK3R1, BTC, MYO5A, BMP2, BMP4, BMP6
35Nanog in Mammalian ESC Pluripotency36INFBTC, BMP2, BMP4, BMP6, BMP7, UTS2
36Activation of cAMP-Dependent PKA36INFPDE3B, GCG, GCGR, BTC, BMP2, BMP4
37Telomerase Components in Cell Signaling36INFBTC, BMP2, BMP4, BMP6, BMP7, UTS2
38Chagas disease (American trypanosomiasis)20INFPIK3R1, PIK3CG, SERPINE1, BDKRB2, CD3D, IRAK1
39JAK-STAT Pathway36INFPIK3R1, BTC, BMP2, BMP4, BMP6, BMP7
40Phospholipase-C Pathway36INFBTC, BMP2, BMP4, BMP6, BMP7, UTS2
41Cellular Apoptosis Pathway36INFPIK3R1, BTC, VDAC1, BMP2, BMP4, BMP6
42CD28 Signaling in T-Helper Cell36INFPIK3R1, PIK3C2A, CD28, CD3D, CD86, CD4
43Glucose / Energy Metabolism3INFPCK2, GCG, LPIN1, LNPEP, LIPE, SCD
44Toxoplasmosis20INFPIK3R1, PIK3CG, BCL2, CIITA, LDLR, CD40LG
45Glucocorticoid Receptor Signaling36INFBMP2, BMP4, BMP6, BMP7, BCL2, BAX
46CREB Pathway36INFPIK3R1, BTC, BMP2, BMP4, BMP6, BMP7
47Immune System38INFPDCD1, PDCD1LG2, KIR2DS5, KIR3DS1, KIR3DL1, KIR2DS2
48Metabolic pathways20INFPIK3C2A, CNDP1, PC, PCK2, PCK1, GCK
49TCR Signaling36INFPIK3R1, CD28, CD3D, CD86, CD4, CD80
50mTOR Pathway36INFPIK3R1, BTC, BMP2, BMP4, BMP6, BMP7

Compounds for genes affiliated with Diabetes Mellitus

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
See all sources

Compounds related to diabetes mellitus according to GeneDecks:

(show top 50)    (show all 551)
idCompoundScoreTop Affiliating Genes
1estrogen32 INFZNF673, PIK3R1, LRP5, COG2, RETN, VWF
2serine32 INFPIK3R1, PIK3CG, PDE3B, RECK, REG1A, RET
3nifedipine32 9 9 INFPIK3CG, REN, GCG, SELE, SERPINE1, NAGLU
4ribonucleic acid32 INFRET, PCSK1, RBP4, SERPINA7, NAMPT, BMP2
5ly29400232 INFPIK3R1, PIK3C2A, PIK3CG, RET, RETN, GCK
6agarose32 INFVWF, SERPINA7, SERPINA1, LPA, BMP7, CLU
7acth32 INFPIK3C2A, PDE3B, REN, PCSK1, SERPINA7, SERPINA1
8arginine32 INFPIK3C2A, COG2, RECK, REN, RET, CNR1
9ascorbic acid32 18 INFPIK3CG, RBP4, NAT1, LPO, VDR, BMP2
10dbc-amp32 INFPDE3B, NAGLU, BMP4, BMP6, LIPE, BDNF
11fatty acid32 INFPIK3C2A, COG2, PDE3B, RECK, RETN, PC
12metformin32 34 9 9 21.3PIK3CG, COG2, RETN, CNR1, VWF, GCK
13polyacrylamide32 18.3RECK, PC, PCSK1, GC, RBP4, SERPINA7
14sb 20358032 42 19.1GCG, SELE, VEGFA, VDR, VCAM1, BMP2
15carbon32 17.3CNR1, CNR2, VWF, PC, NAGA, LPL
16copper32 18 17.2RBP4, SERPINA1, NAGLU, LPA, MT1E, MT2A
17fluvastatin32 34 9 9 18.5PIK3C2A, COG2, VWF, SELP, SERPINE1, LPL
18etoposide32 42 9 9 18.2PIK3R1, PIK3CG, RECK, SELE, CLU, PARP1
19chloroquine32 34 9 9 17.6SERPINC1, BMP6, CIITA, LDLR, B2M, CFTR
20isoproterenol32 9 9 16.2PIK3R1, PDE3B, GCG, SELL, LIPE, KCNQ1
21niacin32 9 9 16.2COG2, SERPINA7, NAMPT, LPA, LPL, LIPE
22glucosamine32 9 18 9 17.0GCK, SELL, SERPINC1, LPL, CD36, CD40
23rosuvastatin32 34 9 9 16.6COG2, LDLR, CETP, INS, IL6, APOA1
24enalapril32 9 9 15.6REN, SERPINE1, NAGLU, BMP6, BMP7, IL10
25fluticasone propionate32 42 9 9 16.4SELE, VCAM1, BGLAP, MPO, MMP9, IL1B
26doxycycline32 9 9 14.7GCK, CD79A, CDKN2B, CDKN2A, CD40LG, CDKN1C
27lactose32 9 9 14.6SELE, SELL, CLEC4A, CFTR, CD40LG, MIF
28thymidylate32 12.6VEGFA, VDR, BCL2, UGT1A1, BAX, MTHFR
29rolipram32 42 13.6PDE3B, SELE, SELL, ITGAM, ITGB2, IL10
30ag 147832 12.5PIK3CG, BTC, SERPINE1, ITGA2, MMP14, MMP2
31poly(i-c)32 12.5VCAM1, CD69, IL12B, IL15, IL18, IL1B
32hirudin32 12.4SELL, SERPINC1, SERPINF2, FGA, FGB, F5
33parthenolide32 12.2PIK3CG, MMP9, IL6, IL8, FASLG, MAPK8
34il-1232 11.9CD86, CD40LG, IL10, IL12B, IL15, IL18
35nitroglycerin32 9 9 13.9COG2, B2M, ALDH2, GNB3, TNFRSF11B, PTGIS
36biotin32 9 18 9 INFVWF, PC, PCK2, GCK, BTD, SELL
37heparin32 9 18 9 INFPIK3C2A, PIK3CG, COG2, RECK, VWF, GCG
38endotoxin32 INFRECK, RETN, PCK2, GC, SELL, SERPINF2
39dexamethasone32 42 34 9 9 INFPIK3R1, REN, RETN, VWF, PC, PCK2
40125i32 INFRECK, SERPINA7, LPO, LMOD1, LIPC, SCARB1
41rapamycin32 42 INFPIK3CG, PCK2, GCG, SELL, VEGFA, BMP2
42succinate32 INFRET, SELE, VDAC1, LMOD1, SDHB, UCP2
43creatinine32 INFREN, RETN, VWF, PCBD1, GCK, GCG
44sialic acid32 INFRECK, RBP4, SELL, SERPINA7, SERPINF2, SERPINA3
45potassium32 9 18 9 INFPIK3C2A, COG2, PDE3B, REN, KIR3DL1, GCK
46pge232 INFPDE3B, REN, SELE, VCAM1, LNPEP, BMP2
47phosphatidylcholine32 INFCNR1, SELE, LPA, LPL, VDAC1, VCAM1
48salbutamol32 34 9 18 9 INFPDE3B, VCAM1, UCP3, CD79A, ITGB2, IL10
49clozapine32 34 9 9 INFSCD, LEP, MPO, IL10, , IL1R1
50phenylephrine32 9 18 9 INFLPL, UTS2, KCNMA1, LEP, CGA, AR

GO Terms for genes affiliated with Diabetes Mellitus

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Sources:
12Gene Ontology
See all sources

Cellular components related to diabetes mellitus according to GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:005576INFPDCD1LG2, REG1A, REG1B, RETN, CNDP1, VWF
2integral to plasma membraneGO:005887INFRET, CNR1, CNR2, KIR2DS5, KIR3DS1, KIR3DL1
3external side of plasma membraneGO:00989715.3VWF, BTLA, SELL, SELP, VCAM1, KCNJ5
4secretory granuleGO:03014113.9PCSK1, GCK, GCG, VEGFA, CHGA, AVP
5platelet alpha granule lumenGO:03109312.9VWF, SERPINF2, SERPINA1, SERPINE1, VEGFA, CLU
6MHC class II protein complexGO:04261312.1HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1
7ER to Golgi transport vesicle membraneGO:01250712.0B2M, HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1
8integral to lumenal side of endoplasmic reticulum membraneGO:07155611.6CALR, HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1
9cytosolGO:005829INFPIK3R1, PIK3C2A, PIK3CG, SH2B3, PDE3B, CNDP2
10extracellular spaceGO:005615INFREN, PCSK1, GCG, GC, BTC, BTD
11plasma membraneGO:005886INFPIK3R1, PIK3C2A, PIK3CG, , LRP5, LRP6
12cell surfaceGO:009986INFLRP6, VEGFA, LPL, VCAM1, BMP2, SCARB1

Biological processes related to diabetes mellitus according to GeneDecks:

(show top 50)    (show all 51)
idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:007267INFPCSK1, NAMPT, LNPEP, BMP2, CGA, AVP
2positive regulation of cell proliferationGO:008284INFLRP5, REG1A, BTC, NAMPT, VEGFA, LEP
3positive regulation of transcription, DNA-dependentGO:045893INFLRP5, LRP6, RET, BMP2, BMP4, BMP7
4negative regulation of apoptotic processGO:043066INFPIK3CG, GCG, BTC, SERPINE1, VEGFA, BMP4
5response to hypoxiaGO:00166617.3SERPINA1, VEGFA, VCAM1, BMP2, UTS2, BCL2
6inflammatory responseGO:00695417.2PIK3CG, CNR2, SELE, SELP, SERPINA3, VNN1
7platelet activationGO:03016816.2PIK3R1, PIK3CG, VWF, SELP, SERPINF2, SERPINA1
8anti-apoptosisGO:00691615.6GCLC, VNN1, VIMP, BDNF, BCL2, MPO
9response to glucocorticoid stimulusGO:05138415.5PCK2, PCSK1, SERPINE1, BGLAP, BCHE, UCP3
10response to lipopolysaccharideGO:03249615.2CNR1, CNR2, PCSK1, SELE, SELP, SERPINA1
11glucose homeostasisGO:04259315.0PDE3B, PCK1, GCK, RBP4, SERPINE1, PAX6
12platelet degranulationGO:00257614.4VWF, SELP, SERPINF2, SERPINA1, SERPINE1, VEGFA
13agingGO:00756814.3CNR1, SERPINA7, VDR, VCAM1, UCP3, IL15
14regulation of insulin secretionGO:05079614.2CNR1, PCSK1, GCK, GCG, KCNJ11, LEP
15female pregnancyGO:00756514.2GC, LNPEP, LIPE, PAPPA, BCL2, LEP
16response to organic cyclic compoundGO:01407014.0SELP, SERPINA1, BMP4, UGT1A1, FXN, IL1A
17cholesterol homeostasisGO:04263213.9LRP5, LIPG, LIPC, SCARB1, LDLR, LCAT
18response to ethanolGO:04547113.9CNR1, RBP4, BGLAP, BCL2, CHAT, S100A8
19response to glucose stimulusGO:00974913.7PCSK1, VIMP, GYS2, IRS2, ARG2, INSR
20response to insulin stimulusGO:03286813.7PCK1, RBP4, BCL2, LEP, UCP3, FOXA2
21response to estradiol stimulusGO:03235513.4GC, SERPINA1, VDR, BMP4, MMP9, INSR
22endocrine pancreas developmentGO:03101813.4PDE3B, GCK, PAX4, FOXA2, INS, IL6
23xenobiotic metabolic processGO:00680513.2CNDP2, GCLC, NAT1, NAT2, PAOX, UGT1A1
24energy reserve metabolic processGO:00611213.2PCSK1, GCG, GCGR, KCNJ11, LEP, LEPR
25regulation of blood pressureGO:00821713.0LRP5, REN, GCGR, UTS2, LEP, CHGA
26T cell costimulationGO:03129513.0PIK3R1, PDCD1, PDCD1LG2, BTLA, CD28, CD3D
27cholesterol metabolic processGO:00820313.0LIPE, LIPC, LEP, LEPR, LDLR, LCAT
28reverse cholesterol transportGO:04369112.7LIPG, LIPC, CLU, SCARB1, LCAT, CETP
29positive regulation of peptidyl-tyrosine phosphorylationGO:05073112.6VEGFA, CD36, CD4, CD80, ITGB3, MIF
30organ regenerationGO:03110012.5UGT1A1, MED1, APOA2, APOA5, APOH, ANGPT2
31positive regulation of protein kinase B signaling cascadeGO:05189712.4PIK3CG, AXL, INS, INSR, ANGPT1, CCL3
32cellular response to lipopolysaccharideGO:07122211.9SERPINE1, VIMP, AXL, CD36, CD14, ARG2
33positive regulation of transcription from RNA polymerase II promoterGO:045944INFLRP5, LRP6, SERPINF2, SERPINE1, VEGFA, VDR
34interferon-gamma-mediated signaling pathwayGO:060333INFVCAM1, CIITA, MT2A, B2M, IFNG, ICAM1
35response to drugGO:042493INFREN, PCSK1, SERPINA7, LPL, UTS2, UTS2R
36small molecule metabolic processGO:044281INFPIK3R1, PIK3C2A, PIK3CG, CNDP2, PC, PCBD1
37positive regulation of apoptotic processGO:043065INFLRP6, CNR1, BMP2, BMP4, CLU, KCNMA1
38positive regulation of angiogenesisGO:045766INFSERPINE1, VEGFA, UTS2, UTS2R, MMP9, FLT1
39cellular response to insulin stimulusGO:032869INFPDE3B, GCK, VIMP, PARP1, IRS1, IRS2
40negative regulation of cell proliferationGO:008285INFVDR, BMP2, BMP4, BDKRB2, UMOD, FTH1
41cytokine-mediated signaling pathwayGO:019221INFVCAM1, CIITA, MT2A, B2M, FLNB, IL1A
42blood coagulationGO:007596INFPIK3R1, PIK3CG, SH2B3, PDE3B, VWF, SELL
43lipid metabolic processGO:006629INFPC, LPA, LPL, LIPG, LIPE, CLU
44positive regulation of cell migrationGO:030335INFRET, VEGFA, BMP2, CGA, MMP14, IRS1
45signal transductionGO:007165INFPDCD1, RET, GCG, NAMPT, LPXN, VDR
46glucose metabolic processGO:006006INFPC, PCK2, PCK1, SERPINA12, KCNJ11, LEP
47lipoprotein metabolic processGO:042157INFLPA, LPL, SDC1, SCARB1, LDLR, LCAT
48carbohydrate metabolic processGO:005975INFPC, PCK2, PCK1, GCKR, GCK, NAGLU
49response to estrogen stimulusGO:043627INFSERPINE1, BGLAP, BCL2, MSTN, APOA2, FAS
50immune responseGO:006955INFPDCD1LG2, CNR2, KIR2DS5, KIR3DS1, KIR3DL1, KIR2DS2

Molecular functions related to diabetes mellitus according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510216.3UTS2, RARRES2, BMP2, LPL, SERPINE1, GCG
2hormone activityGO:00517914.8NPPA, POMC, PRL, TG, TTR, AGT
3cytokine activityGO:00512514.1GDF15, ADIPOQ, CSF2, CSF1, TGFB2, EDN1
4heparin bindingGO:00820113.7CTGF, PTPRC, HRG, CCL5, CCL2, APP
5protein heterodimerization activityGO:04698213.7TLR2, AGTR1, HEXB, ABCG1, EGFR, PDGFB
6growth factor activityGO:00808313.7HGF, CTGF, GH1, F2, IGF1, IGF2
7heme bindingGO:02003713.2PTGS1, LPO, MPO, PTGS2, PTGIS, TPO
8protease bindingGO:00202012.5POLG, INSL3, INS, CD28, BCL2, BDKRB2
9enzyme bindingGO:01989911.8CYP2C19, CYP3A4, PTPN1, PTGS2, PTEN, TP53
10protein bindingGO:005515INFGATA3, GAD2, GAPDH, , GAD1, EPO
11protein homodimerization activityGO:042803INFADRB3, ADD1, ADRA2C, ADRB2, WRN, CPQ

Sources for Diabetes Mellitus

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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