MCID: DBT009
MIFTS: 78

Diabetes Mellitus malady

Genetic diseases, Endocrine diseases, Rare diseases categories

Summaries for Diabetes Mellitus

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35MedlinePlus, 4CDC, 47Novus Biologicals, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. glucose comes from the foods you eat. insulin is a hormone that helps the glucose get into your cells to give them energy. with type 1 diabetes, your body does not make insulin. with type 2 diabetes, the more common type, your body does not make or use insulin well. without enough insulin, the glucose stays in your blood. you can also have prediabetes. this means that your blood sugar is higher than normal but not high enough to be called diabetes. having prediabetes puts you at a higher risk of getting type 2 diabetes. over time, having too much glucose in your blood can cause serious problems. it can damage your eyes, kidneys, and nerves. diabetes can also cause heart disease, stroke and even the need to remove a limb. pregnant women can also get diabetes, called gestational diabetes. a blood test can show if you have diabetes. exercise, weight control and sticking to your meal plan can help control your diabetes. you should also monitor your glucose level and take medicine if prescribed. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and type 1 diabetes mellitus. An important gene associated with Diabetes Mellitus is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Adipogenesis and FoxO signaling pathway. The drug chromium picolinate and the compounds 3-o-methylglucose and minoxidil have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related mouse phenotypes are muscle and renal/urinary system.

CDC:4 CDC's Division of Diabetes Translation translates diabetes research into daily practice to understand the impact of the disease, influence health outcomes, and improve access to quality health care.

Novus Biologicals:47 Diabetes is a disease in which the body does not produce or properly use insulin. There are four major types of diabetes: Type 1, Type 2, Gestational and Pre-Diabetes. Type 1 diabetes, previously known as juvenile diabetes, is an autoimmune disease resulting when one's own immune system destroys insulin-producing beta cells in the pancreas. This causes the pancreas to produce little or no insulin. In type 2 diabetes, the body either does not produce enough insulin or beta cells ignore insulin. Gestational diabetes refers to high glucose levels caused by pregnancy. Pre-diabetes is a condition in which blood glucose levels are high, but not high enough for the diagnosis of type 2 diabetes.

Wikipedia:66 Diabetes mellitus (DM) also known as simply diabetes, is a group of metabolic diseases in which there... more...

Description from OMIM:48 222100

Aliases & Classifications for Diabetes Mellitus

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Sources:
9Disease Ontology, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 36MeSH, 28ICD9CM, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases
ICD10: 26



Aliases & Descriptions:

diabetes mellitus 9 11 46 63
diabetes 9 48 35 63
diabetes nos 9


Related Diseases for Diabetes Mellitus

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Type 1 Diabetes Mellitus family:

diabetes mellitus Type 2 Diabetes Mellitus

Diseases related to Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1591)
idRelated DiseaseScoreTop Affiliating Genes
1type 2 diabetes mellitus32.7KCNJ11, TNDM
2type 1 diabetes mellitus32.4INS, PTPRN, HNF4A, GCK, CTLA4
3gestational diabetes32.1ABCC8, KCNJ11, INS, PTPRN, HNF4A, SLC2A4
4insulin resistance31.8INS, ABCC8, IAPP, IL6, SLC2A4, GCK
5obesity31.8SLC2A2, SLC2A4, GCK, HNF4A, IL6, IAPP
6neonatal diabetes mellitus31.8SLC2A2, GCK, PDX1, HNF1B, ABCC8, KCNJ11
7diabetic nephropathy31.6IAPP, INS, HNF1B
8permanent neonatal diabetes mellitus31.5INS, KCNJ11, ABCC8
9hypoglycemia31.4SLC2A2, ABCC8, INS, KCNJ11, GCK, HNF4A
10hepatitis31.3HGF, CTLA4, HNF4A
11hyperglycemia31.3HNF1B, ABCC8, KCNJ11, INS, SLC2A2, SLC2A4
12diabetic ketoacidosis31.3CTLA4, INS
13glucose intolerance31.1GCK, PDX1, SLC2A4, IAPP, INS
14ischemia30.9ABCC8, GCK, SLC2A4, HGF
15hyperinsulinism30.9GCK, KCNJ11, INS, ABCC8
16maturity-onset diabetes of the young30.9KCNJ11, INS, NEUROD1, HNF1B, HNF4A, PDX1
17pancreatic agenesis30.8PDX1
18insulinoma30.8ABCC8, KCNJ11, INS, PTPRN, IAPP, ICA1
19liver cirrhosis30.6SLC2A4, HNF4A, HGF
20pancreatic cancer30.6INS, HGF, IAPP, SLC2A4, PDX1, HNF4A
21hyperinsulinemic hypoglycemia30.5ABCC8, INS
22hyperuricemia30.5INS, HNF1B, GCK
23prostate cancer30.5HNF4A, CTLA4, HNF1B, IL6, HGF
24kidney cancer30.5HNF4A, HGF, SLC2A4, CTLA4, HNF1B
25galactosemia30.4HGF, INS, CTLA4, HNF4A, HNF1B
26diabetes mellitus, noninsulin-dependent30.4ABCC8, NEUROD1, HNF1B, HNF4A, SLC2A4, SLC2A2
27breast cancer30.4SLC2A4, SLC2A2, INS, IAPP, PLAGL1, CTLA4
28adenoma30.4HNF4A, INS, PLAGL1, CTLA4
29diabetes mellitus, permanent neonatal, with neurologic features30.4TNDM, KCNJ11
30diabetes mellitus, transient neonatal, 330.4TNDM, KCNJ11
31metabolic syndrome x30.3SLC2A4, INS
32hepatocellular carcinoma30.3IL6, HGF, SLC2A2, INS, CTLA4, HNF1B
33adenocarcinoma30.2HNF4A, PDX1, SLC2A4, IAPP, NEUROD1, HGF
34diabetes, permanent neonatal30.2TNDM, KCNJ11
35beckwith-wiedemann syndrome30.1ABCC8, PLAGL1, ZFP57
36ovarian cancer30.1HNF1B, HNF4A, PLAGL1, SLC2A4
37chronic kidney failure30.0HGF, IL6, INS, HNF1B
38endometriosis29.7HGF, HNF1B, IL6
39primary hyperoxaluria29.5HNF1B, HGF, IL6, CTLA4, INS, IAPP
40hypertension11.1
41endotheliitis11.0
42neuropathy11.0
43pancreatitis11.0
44nephrogenic diabetes insipidus11.0
45artery disease10.9
46coronary artery disease10.9
47atherosclerosis10.9
48autonomic neuropathy10.9
49transient neonatal diabetes mellitus10.9
50thyroiditis10.9

Graphical network of the top 20 diseases related to Diabetes Mellitus:



Diseases related to diabetes mellitus

Symptoms for Diabetes Mellitus

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Sources:
48OMIM
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Clinical features from OMIM:

222100

Drugs & Therapeutics for Diabetes Mellitus

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Diabetes Mellitus

Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus

Search NIH Clinical Center for Diabetes Mellitus

Search CenterWatch for Diabetes Mellitus

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Diabetes Mellitus

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Anatomical Context for Diabetes Mellitus

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34MalaCards
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MalaCards organs/tissues related to Diabetes Mellitus:

34
Heart, Endothelial, Kidney, Testes, Pancreas, Liver, Thyroid, Bone, Eye, Skeletal muscle, Monocytes, Brain, Pancreatic islet, T cells, Skin, Ovary, Placenta, Adipocyte, Pituitary, Lung, Breast, B cells, Prostate, Colon, Smooth muscle, Retina, Pons, Myeloid, Bone marrow, Small intestine, Whole blood, Tongue, Hypothalamus, Spleen, Spinal cord, Thymus, Cortex, Testis

Animal Models for Diabetes Mellitus or affiliated genes

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38MGI
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Publications for Diabetes Mellitus

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53PubMed
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Articles related to Diabetes Mellitus:

(show top 50)    (show all 7698)
idTitleAuthorsYear
1
Mutilating fingertip ulcers in uncontrolled type 1 diabetes mellitus. (23887501)
2014
2
Nephron filtration rate and proximal tubular fluid reabsorption in the Akita mouse model of type I diabetes mellitus. (24358878)
2013
3
Albuminuria and management of type 2 diabetes mellitus. (23880799)
2013
4
Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: a clinical study. (23678391)
2013
5
Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial. (24169612)
2013
6
Type 2 diabetes mellitus and invokana: an FDA approved drug. (24160357)
2013
7
Glycated albumin versus glycated hemoglobin as glycemic indicator in hemodialysis patients with diabetes mellitus: variables that influence. (23538348)
2013
8
The prevalence of orthostatic hypotension in type 2 diabetes mellitus patients in a diabetic clinic in Enugu South-East Nigeria. (24180143)
2013
9
Insulin pump: A popular device for management of type 1 diabetes mellitus. (24381902)
2013
10
Preliminary results of pinpoint plantar long-wavelength infrared light irradiation on blood glucose, insulin and stress hormones in patients with type 2 diabetes mellitus. (24204095)
2013
11
Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta. (23954530)
2013
12
Lipids and lipoprotein ratios: contribution to carotid intima media thickness in adolescents and young adults with type 2 diabetes mellitus. (24079285)
2013
13
Circadian clock gene expression is impaired in gestational diabetes mellitus. (23323702)
2013
14
Factors related to nephrotic-range proteinuria in late-stage chronic kidney disease patients with diabetes mellitus. (23355027)
2013
15
An association between gestational diabetes mellitus and long-term maternal cardiovascular morbidity. (23749791)
2013
16
Plasma adrenomedullin and subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus. (22971508)
2012
17
Clinical profiles and long-term outcomes of patients with pancreatic ductal adenocarcinoma and diabetes mellitus. (22423386)
2012
18
Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. (22119899)
2012
19
Association of interleukin-4 promoter polymorphisms in Taiwanese patients with type 2 diabetes mellitus. (20580039)
2010
20
Pathophysiology of diabetes mellitus in Cushing's syndrome. (20829623)
2010
21
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
22
Exercise training ameliorates the effects of rosiglitazone on traditional and novel cardiovascular risk factors in patients with type 2 diabetes mellitus. (19922961)
2010
23
Customized cell-based treatment options to combat autoimmunity and restore beta-cell function in type 1 diabetes mellitus: current protocols and future perspectives. (20217518)
2010
24
Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management. (20107300)
2010
25
Idiopathic sudden sensorineural hearing loss: evolution in the presence of hypertension, diabetes mellitus and dyslipidemias. (20658017)
2010
26
Pleiotropic effects of mitiglinide in type 2 diabetes mellitus. (20146890)
2009
27
Long-term pioglitazone therapy improves arterial stiffness in patients with type 2 diabetes mellitus. (19446110)
2009
28
Is there a need for dietary measures to further reduce LDL cholesterol in patients with type II diabetes mellitus on statin therapy? (18684421)
2008
29
Miglitol increases the adiponectin level and decreases urinary albumin excretion in patients with type 2 diabetes mellitus. (17950094)
2007
30
The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. (17578587)
2007
31
Effects of carvedilol versus metoprolol on endothelial function and oxidative stress in patients with type 2 diabetes mellitus. (17586413)
2007
32
Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus. (16513827)
2006
33
Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults. (16061833)
2005
34
Superior segmental optic nerve hypoplasia and diabetes mellitus. (15866063)
2005
35
Long-term treatment with nifedipine modulates procoagulant marker and C-C chemokine in hypertensive patients with type 2 diabetes mellitus. (15668187)
2005
36
High serum interleukin-18 concentrations in patients with coronary artery disease and type 2 diabetes mellitus. (16266856)
2005
37
Adiponectin and risk of new-onset diabetes mellitus after kidney transplantation. (15257035)
2004
38
Enhanced leukocyte-platelet cross-talk in Type 1 diabetes mellitus: relationship to microangiopathy. (14717967)
2004
39
Olanzapine-induced diabetes mellitus]. (12224043)
2002
40
Analysis of slc19a2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in pima indians. (11286512)
2001
41
Prediction of insulin-dependent diabetes mellitus in children of first-degree relatives of diabetic patients]. (11678027)
2001
42
Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization. (10333057)
1999
43
Clinical efficacy of acarbose in diabetes mellitus: a critical review of controlled trials. (9805641)
1998
44
The association between retinopathy, nephropathy, cardiovascular disease and long-term metabolic control in type 1 diabetes mellitus: a 5 year follow-up study of 442 adult patients in routine care. (9179466)
1997
45
Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. (9056694)
1997
46
Drug treatment of non-insulin-dependent diabetes mellitus in the 1990s. Achievements and future developments. (9279500)
1997
47
Salivary peroxidase activity in whole saliva of patients with insulin-dependent (type-1) diabetes mellitus. (8891941)
1996
48
Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus. (7853952)
1995
49
Population analysis of protection by HLA-DR and DQ genes from insulin-dependent diabetes mellitus in Swedish children with insulin-dependent diabetes and controls. (8597561)
1995
50
Islet amyloid polypeptide (IAPP) secretion from islet cells and its plasma concentration in patients with non-insulin-dependent diabetes mellitus. (1541240)
1992

Variations for Diabetes Mellitus

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Diabetes Mellitus:

1
id Gene Name Type Significance SNP ID Assembly Location
1HNF1ANM_000545.5(HNF1A): c.872dupC (p.Gly292Argfs)duplicationPathogenic/card/diabetes_mellitusGRCh37Chr 12, 121432125: 121432125

Expression for genes affiliated with Diabetes Mellitus

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus

Search GEO for disease gene expression data for Diabetes Mellitus.

Pathways for genes affiliated with Diabetes Mellitus

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 55R&D Systems, 61Thomson Reuters, 54QIAGEN, 56Reactome, 13EMD Millipore, 5Cell Signaling Technology, 52PharmGKB
See all sources

Pathways related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2SLC2A4, IL6, INS
2
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
10.2INS, IL6, SLC2A4
3
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
10.2INS, IL6, SLC2A4
410.2ABCC8, KCNJ11, SLC2A4
510.2GCK, IL6, NEUROD1
6
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
10.2SLC2A2, GCK, INS
7
Show member pathways
10.2GCK, SLC2A4, SLC2A2
8
Show member pathways
glycolysis39
gluconeogenesis39
Glycolysis and Gluconeogenesis39
10.2GCK, SLC2A4, SLC2A2
910.2SLC2A2, SLC2A4, HNF4A
10
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
10.1SLC2A4, GCK, HGF, INS
11
Show member pathways
10.1ABCC8, KCNJ11, INS, SLC2A2
12
Show member pathways
10.0INS, NEUROD1, HNF4A, GCK, SLC2A2
13
Show member pathways
10.0CTLA4, IL6, ICA1, PTPRN, INS
1410.0INS, IAPP, HNF1B, PDX1, SLC2A2
15
Show member pathways
9.9ABCC8, KCNJ11, INS, PDX1, GCK, SLC2A2
16
Show member pathways
9.9PTPRN, IL6, HGF, HNF4A, SLC2A4, SLC2A2
179.9INS, NEUROD1, WFS1, HNF4A, PDX1, SLC2A4
189.8ABCC8, KCNJ11, INS, HNF4A, PDX1, GCK
19
Show member pathways
9.7INS, NEUROD1, IAPP, HNF1B, HNF4A, PDX1
20
Show member pathways
9.5INS, NEUROD1, IAPP, HNF1B, HNF4A, PDX1
21
Show member pathways
9.5SLC2A2, ABCC8, KCNJ11, SLC2A4, GCK, PDX1

Compounds for genes affiliated with Diabetes Mellitus

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB
See all sources

Compounds related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
13-o-methylglucose4610.5GCK, SLC2A4, SLC2A2
2minoxidil46 30 1212.5ABCC8, KCNJ11, HGF
3gliclazide46 52 1212.5SLC2A4, KCNJ11, ABCC8, INS
4preproinsulin4610.5INS, SLC2A2, PDX1, GCK
5tolbutamide46 30 52 1213.5KCNJ11, GCK, INS, ABCC8
6glimepiride46 52 1212.5INS, SLC2A4, ABCC8, KCNJ11
7i-app4610.5PDX1, IAPP, INS, GCK
8nicotinamide46 1211.5HGF, HNF1B, INS, PDX1
9cibenzoline4610.5KCNJ11, ABCC8
10proglucagon4610.4SLC2A2, PDX1, GCK
11diazoxide46 62 30 1213.4TNDM, KCNJ11, INS, GCK, ABCC8
12repaglinide52 46 1212.4NEUROD1, INS, IAPP, KCNJ11, ABCC8
13phosphoenolpyruvate46 1211.4SLC2A2, SLC2A4, GCK, HNF4A
142-deoxyglucose46 1211.4INS, GCK, SLC2A4, SLC2A2
15incretin4610.4GCK, PDX1, IAPP, SLC2A2, INS
16katp4610.4ABCC8, KCNJ11, INS, GCK, SLC2A2, PDX1
17metformin46 52 1212.3GCK, IAPP, ABCC8, SLC2A4, INS, KCNJ11
18ly2940024610.3GCK, HGF, SLC2A4, CTLA4, IL6, INS
19glibenclamide46 30 52 6213.3TNDM, ABCC8, IAPP, SLC2A4, INS, KCNJ11
20pyruvate4610.3HNF4A, GCK, HGF, SLC2A4, PDX1, SLC2A2
21fatty acid4610.3HGF, SLC2A4, HNF4A, GCK, INS, ABCC8
22lactate4610.2HGF, IAPP, GCK, IL6, INS, SLC2A4
23indomethacin46 30 62 1213.2SLC2A4, HNF4A, HGF, IL6, IAPP
24streptozotocin4610.2HGF, INS, PDX1, SLC2A4, SLC2A2, GCK
25thymidine46 2511.2HGF, PDX1, HNF4A, IL6, IAPP, CTLA4
26wortmannin4610.2PDX1, SLC2A4, CTLA4, HGF, INS
27norepinephrine46 25 1212.2SLC2A4, HGF, IL6, INS, IAPP
28creatinine4610.2IL6, SLC2A4, INS, HGF, IAPP, GCK
29sulfonylurea4610.1ABCC8, INS, IAPP, PDX1, GCK, SLC2A4
30cholesterol46 30 25 1213.1IAPP, CTLA4, GCK, HNF4A, HNF1B, IL6
31alanine4610.1CTLA4, SLC2A4, GCK, INS, IL6, HGF
32testosterone46 62 25 1213.1ABCC8, IL6, HNF4A, PLAGL1, INS, IAPP
33dexamethasone46 52 30 1213.1CTLA4, SLC2A4, HNF4A, HGF, IL6, INS
34glycogen46 2511.1HGF, IAPP, HNF4A, SLC2A4, ABCC8, SLC2A2
35ibmx46 62 3012.1SLC2A4, SLC2A2, IAPP, INS
36c-peptide4610.1PDX1, IAPP, PTPRN, INS, KCNJ11, HNF4A
37retinoic acid46 2511.1HGF, SLC2A4, PDX1, GCK, NEUROD1, IL6
38sterol4610.1HNF4A, SLC2A2, SLC2A4, GCK
39lipid4610.0CTLA4, SLC2A4, GCK, HNF4A, IL6, IAPP
40potassium46 25 1212.0ABCC8, SLC2A2, GCK, HGF, KCNJ11
41atp46 3011.0ABCC8, KCNJ11, SLC2A2, GCK, HGF, IAPP
42glutamate4610.0PTPRN, GCK, CTLA4, HNF4A, HGF, ICA1
43serine4610.0PDX1, ABCC8, SLC2A4, CTLA4, GCK, HNF4A
44oligonucleotide4610.0SLC2A2, GCK, PDX1, HNF4A, HNF1B, IAPP
45arginine469.9GCK, HNF1B, IAPP, ABCC8, SLC2A2, KCNJ11
46tyrosine469.9PTPRN, CTLA4, HNF4A, IL6, HGF, ICA1
47calcium46 52 25 1212.9GCK, CTLA4, PDX1, HNF4A, HGF, WFS1
48forskolin46 52 1211.8SLC2A4, GCK, PDX1, IAPP, SLC2A2
49phosphatidylinositol469.6SLC2A4, CTLA4, PDX1, HNF4A, HGF, INS
50glucose469.5HNF4A, NEUROD1, HNF1B, IL6, IAPP, PTPRN

GO Terms for genes affiliated with Diabetes Mellitus

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Sources:
17Gene Ontology
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Biological processes related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1detection of glucoseGO:05159410.6GCK, PDX1
2negative regulation of gluconeogenesisGO:04572110.6INS, IL6, GCK
3neurological system processGO:05087710.5WFS1, KCNJ11
4negative regulation of type B pancreatic cell apoptotic processGO:200067510.5WFS1, NEUROD1
5positive regulation of glycolytic processGO:04582110.5GCK, INS
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5INS, IL6, HGF
7insulin secretionGO:03007310.5NEUROD1, HNF1B, PDX1
8positive regulation of glycogen biosynthetic processGO:04572510.4GCK, INS
9hexose transportGO:00864510.4SLC2A2, SLC2A4, GCK
10energy reserve metabolic processGO:00611210.4SLC2A2, INS, KCNJ11, ABCC8
11glucose transportGO:01575810.4INS, GCK, SLC2A4, SLC2A2
12response to glucoseGO:00974910.4HNF4A, HNF1B, NEUROD1, PTPRN
13nitric oxide mediated signal transductionGO:00726310.3PDX1, NEUROD1
14response to drugGO:04249310.3KCNJ11, NEUROD1, IL6, PDX1
15glucose metabolic processGO:00600610.3KCNJ11, INS, PDX1
16positive regulation of cell differentiationGO:04559710.3NEUROD1, INS
17carbohydrate metabolic processGO:00597510.3ABCC8, GCK, SLC2A4, SLC2A2
18signal transduction involved in regulation of gene expressionGO:02301910.2HNF4A, NEUROD1
19regulation of insulin secretionGO:05079610.2GCK, HNF4A, NEUROD1, INS, KCNJ11, ABCC8
20positive regulation of transcription from RNA polymerase II promoterGO:04594410.1NEUROD1, IL6, PLAGL1, HGF, HNF1B, HNF4A
21glucose homeostasisGO:04259310.1INS, NEUROD1, WFS1, HNF4A, PDX1, GCK
22endocrine pancreas developmentGO:0310189.9SLC2A2, INS, NEUROD1, IAPP, IL6, HNF1B
23small molecule metabolic processGO:0442819.9ABCC8, KCNJ11, INS, GCK, SLC2A4, SLC2A2
24positive regulation of transcription, DNA-templatedGO:0458939.8NEUROD1, IL6, HNF1B, HNF4A

Molecular functions related to Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:04698210.1PDX1, HNF1B, HGF, NEUROD1
2D-glucose transmembrane transporter activityGO:05505610.0SLC2A2, SLC2A4

Products for genes affiliated with Diabetes Mellitus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetes Mellitus

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet