MCID: DBT009
MIFTS: 80

Diabetes Mellitus malady

Endocrine diseases category

Summaries for Diabetes Mellitus

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33MedlinePlus, 3CDC, 45Novus Biologicals, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. glucose comes from the foods you eat. insulin is a hormone that helps the glucose get into your cells to give them energy. with type 1 diabetes, your body does not make insulin. with type 2 diabetes, the more common type, your body does not make or use insulin well. without enough insulin, the glucose stays in your blood. over time, having too much glucose in your blood can cause serious problems. it can damage your eyes, kidneys, and nerves. diabetes can also cause heart disease, stroke and even the need to remove a limb. pregnant women can also get diabetes, called gestational diabetes. a blood test can show if you have diabetes. exercise, weight control and sticking to your meal plan can help control your diabetes. you should also monitor your glucose level and take medicine if prescribed. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes. An important gene associated with Diabetes Mellitus is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Type II diabetes mellitus and Regulation of beta-cell development. The drug chromium picolinate and the compounds glucose and arginine have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

CDC:3 CDC's Division of Diabetes Translation translates diabetes research into daily practice to understand the impact of the disease, influence health outcomes, and improve access to quality health care.

Novus Biologicals:45 Diabetes is a disease in which the body does not produce or properly use insulin. There are four major types of diabetes: Type 1, Type 2, Gestational and Pre-Diabetes. Type 1 diabetes, previously known as juvenile diabetes, is an autoimmune disease resulting when one's own immune system destroys insulin-producing beta cells in the pancreas. This causes the pancreas to produce little or no insulin. In type 2 diabetes, the body either does not produce enough insulin or beta cells ignore insulin. Gestational diabetes refers to high glucose levels caused by pregnancy. Pre-diabetes is a condition in which blood glucose levels are high, but not high enough for the diagnosis of type 2 diabetes.

Wikipedia:63 Diabetes mellitus (DM) or simply diabetes, is a group of metabolic diseases in which a person has high... more...

Description from OMIM:46 222100

Aliases & Classifications for Diabetes Mellitus

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 46OMIM, 33MedlinePlus, 39NCIt, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases
ICD10: 25



Aliases & Descriptions:

diabetes mellitus 8 10 44 60
diabetes 8 46 33 60
diabetes nos 8


Related Diseases for Diabetes Mellitus

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Type 2 Diabetes Mellitus family:

Type 1 Diabetes Mellitus diabetes mellitus

Diseases related to Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1415)
idRelated DiseaseScoreTop Affiliating Genes
1type 2 diabetes mellitus32.4SLC2A4, HNF1B
2gestational diabetes31.9PTPRN, SLC2A4, ABCC8, LEP, IAPP, CAPN10
3obesity31.7SLC2A4, ABCC8, LEP, IL6, IAPP, AKR1B1
4neonatal diabetes mellitus31.6PLAGL1, ABCC8, PDX1, HNF1B, GCK, KCNJ11
5hypertension31.6LEP
6neuropathy31.5AKR1B1
7pancreatitis31.5IL6
8diabetic retinopathy31.4AKR1B1
9atherosclerosis31.3LEP, IL6, AKR1B1, CAPN10
10hepatitis31.2CTLA4, HGF
11hyperglycemia31.2PTPRN, SLC2A2, SLC2A4, ABCC8, LEP, IAPP
12permanent neonatal diabetes mellitus31.2ABCC8, KCNJ11
13thyroiditis31.2CTLA4
14hypoglycemia31.2AKR1B1, GCK, KCNJ11, IAPP, SLC2A2, SLC2A4
15type 1 diabetes31.1PTPRN, CTLA4, GCK
16myocardial infarction31.1AKR1B1, PDX1
17celiac disease31.1CTLA4
18glucose intolerance31.0KCNJ11, GCK, SLC2A2, SLC2A4, ABCC8, LEP
19periodontal disease30.9IL6
20ischemia30.8GCK, HGF, AKR1B1, ABCC8, SLC2A4
21essential hypertension30.8LEP, IAPP
22hypothyroidism30.8LEP, CTLA4
23polycystic ovary syndrome30.7CAPN10, LEP, SLC2A4
24maturity-onset diabetes of the young30.7KCNJ11, GCK, HNF1B, PDX1, NEUROD1
25proliferative diabetic retinopathy30.7HGF
26hyperinsulinism30.7KCNJ11, GCK, LEP, ABCC8
27insulinoma30.7PTPRN, SLC2A2, ABCC8, IAPP, WFS1, PDX1
28liver cirrhosis30.6SLC2A4, LEP, HGF, GCK
29morbid obesity30.6LEP
30cystic fibrosis30.6KCNJ11, CAPN10, ABCC8
31cataract30.6AKR1B1, CAPN10
32hyperandrogenism30.5LEP, CAPN10
33pancreatic cancer30.5HGF, PDX1, IAPP, SLC2A4
34hyperthyroidism30.5CTLA4, LEP
35acute pancreatitis30.5IAPP, IL6
36prostate cancer30.4HNF1B, HGF, CTLA4, IL6
37myopathy30.4SLC2A4
38galactosemia30.3HNF1B, HGF, CTLA4, LEP
39diabetes mellitus, noninsulin-dependent30.2HNF1B, NEUROD1, ABCC8, SLC2A4
40hyperinsulinemic hypoglycemia30.2ABCC8, GCK, KCNJ11
41adenoma30.2PLAGL1, CTLA4
42hyperuricemia30.2GCK, HNF1B
43adenocarcinoma30.1HNF1B, HGF, PDX1, NEUROD1, IAPP, SLC2A4
44metabolic syndrome x30.1SLC2A4, LEP
45vitiligo30.1CTLA4
46myeloma30.1IL6, HGF
47pheochromocytoma30.0IAPP
48chronic kidney failure29.9HNF1B, HGF, AKR1B1, IL6, LEP
49pituitary adenoma29.9ABCC8, LEP, NEUROD1
50beckwith-wiedemann syndrome29.9ZFP57, ABCC8, PLAGL1

Graphical network of the top 20 diseases related to Diabetes Mellitus:



Diseases related to diabetes mellitus

Clinical Features for Diabetes Mellitus

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46OMIM
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Clinical features from OMIM:

222100

Drugs & Therapeutics for Diabetes Mellitus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetes Mellitus

Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus

Search NIH Clinical Center for Diabetes Mellitus

Search CenterWatch for Diabetes Mellitus

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Diabetes Mellitus

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Anatomical Context for Diabetes Mellitus

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32MalaCards
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MalaCards organs/tissues related to Diabetes Mellitus:

32
Heart, Endothelial, Kidney, Testes, Pancreas, Liver, Thyroid, Bone, Eye, Skeletal muscle, Monocytes, Brain, Pancreatic islet, T cells, Ovary, Skin, Placenta, Pituitary, Adipocyte, Lung, Breast, B cells, Prostate, Colon, Smooth muscle, Retina, Pons, Myeloid, Bone marrow, Small intestine, Whole blood, Tongue, Hypothalamus, Spleen, Spinal cord, Thymus, Cortex, Testis

Animal Models for Diabetes Mellitus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetes Mellitus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537614.0PDX1, ABCC8, SLC2A4, PTPRN, AKR1B1, SLC2A2
2MP:001076813.5LEP, PDX1, ICA1, CTLA4, AKR1B1, NEUROD1
3MP:000537813.4CAPN10, SLC2A4, PLAGL1, LEP, IL6, IAPP
4MP:000537913.2ABCC8, KCNJ11, GCK, HNF1B, PTPRN, CAPN10
5MP:000538712.3HNF1B, IL6, PTPRN, LEP, IAPP, CTLA4
6MP:000537012.2SLC2A4, LEP, IL6, CTLA4, PDX1, CAPN10
7MP:000536712.0LEP, CAPN10, IL6, NEUROD1, GCK, HNF1B
8MP:000538511.8LEP, PLAGL1, SLC2A4, KCNJ11, HGF, CAPN10
9MP:001077111.5PLAGL1, LEP, WFS1, CTLA4, PDX1, KCNJ11
10MP:000537511.4SLC2A4, LEP, IL6, CAPN10, KCNJ11

Publications for Diabetes Mellitus

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50PubMed
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Articles related to Diabetes Mellitus:

(show top 50)    (show all 7777)
idTitleAuthorsYear
1
Computer-based programmed instruction did not improve the knowledge retention of medication instructions of individuals with type 2 diabetes mellitus. (24168837)
2014
2
Prophylactic Add-on Antiplatelet Therapy in Chronic Kidney Disease With Type 2 Diabetes Mellitus: Comparison Between Clopidogrel and Low-dose Aspirin. (24049616)
2013
3
The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus. (23206673)
2013
4
Osteoprotegerin, leptin and IL-6: association with silent myocardial ischemia in type 2 diabetes mellitus. (22496403)
2013
5
Predictors of diabetic foot and leg ulcers in a developing country with a rapid increase in the prevalence of diabetes mellitus. (24223231)
2013
6
Evolution of Wernicke-Korsakoff syndrome in self-neglecting alcoholics: preliminary results of relation with Wernicke-delirium and diabetes mellitus. (22332852)
2012
7
Slowly progressive insulin-dependent diabetes mellitus associated with pernicious anemia. (20075581)
2010
8
An intriguing association between congestive heart failure and diabetes mellitus. (20368079)
2010
9
Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus. (19837930)
2009
10
New treatments for type 2 diabetes mellitus: combined therapy with sitagliptin. (18518780)
2008
11
Retinol-binding protein 4 responses during an oral glucose tolerance testing in women with gestational diabetes mellitus. (18328819)
2008
12
Variation in associations between allelic variants of the vitamin D receptor gene and onset of type 1 diabetes mellitus by ambient winter ultraviolet radiation levels: a meta-regression analysis. (18552362)
2008
13
Antioxidant status in type II diabetes mellitus patients with or without microvascular complications]. (17642450)
2007
14
Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus. (17596103)
2007
15
The effects of visceral fat accumulation by diabetes mellitus on bone metabolism]. (16883042)
2006
16
Effects of gestational diabetes mellitus on proteins implicated in insulin signaling in human placenta. (17071539)
2006
17
Beta2-adrenergic receptor and UCP3 variants modulate the relationship between age and type 2 diabetes mellitus. (17150099)
2006
18
Metformin monotherapy for type 2 diabetes mellitus. (16034881)
2005
19
Analysis of small dense LDL in patients with type 2 diabetic mellitus by the modified Krauss method using an internal standard]. (16235834)
2005
20
Insulin Resistance and Diabetes Mellitus in HIV-Infected Patients Receiving Antiretroviral Therapy. (18370693)
2004
21
Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. (14715842)
2004
22
Polymorphisms in the von Willebrand factor gene are not associated with proliferative retinopathy in non-insulin-dependent diabetes mellitus. (12381897)
2002
23
Effect of oxidative stress on glutathione pathway in red blood cells from patients with insulin-dependent diabetes mellitus. (12370859)
2002
24
Angiotensin II type-1 receptor antagonists and diabetes mellitus]. (11450165)
2001
25
Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus. (11444416)
2001
26
Adrenomedullin and diabetes mellitus. (11747138)
2001
27
Combined metformin and insulin therapy for patients with type 2 diabetes mellitus. (10929918)
2000
28
Inefficiency of insulin therapy to correct apolipoprotein A-I metabolic abnormalities in non-insulin-dependent diabetes mellitus. (10996359)
2000
29
The significance of A1 and A2 antibodies against beta-casein in type-1 diabetes mellitus]. (10633778)
1999
30
Tumor necrosis factor-alpha; a possible pathogenic factor in obesity in insulin resistant and non-insulin-dependent diabetes mellitus?]. (9685802)
1998
31
Effect of adding a sulfonylurea in patients with non-insulin-dependent diabetes mellitus previously well controlled with insulin. (15251771)
1997
32
Insulin resistance implications for type II diabetes mellitus and coronary heart disease. (9274899)
1997
33
Growth parameters, growth hormone (GH) response to clonidine and circulating insulin-like growth factor-I (IGF-I), free thyroxine (FT4) and cortisol concentrations in relation to glycaemic control in children with insulin-dependent diabetes mellitus. (8816035)
1996
34
The prognostic value of albuminuria for the development of cardiovascular disease and retinopathy: a 5-year follow-up of 451 patients with type 2 diabetes mellitus. (8803480)
1996
35
Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men. MRFIT Research Group. Multiple Risk Factor Intervention Trial. (8610702)
1996
36
Urinary enzymes in insulin-dependent diabetes mellitus]. (8999662)
1996
37
Resistance to insulin-mediated glucose disposal in patients with noninsulin-dependent diabetes mellitus in the absence of obesity or microalbuminuria--a Clinical Research Center study. (8772592)
1996
38
Plasma semicarbazide-sensitive amine oxidase activity is elevated in diabetes mellitus and correlates with glycosylated haemoglobin. (7634751)
1995
39
More uniform diurnal blood glucose control and a reduction in daily insulin dosage on addition of glibenclamide to insulin in type 1 diabetes mellitus: role of enhanced insulin sensitivity. (8846678)
1995
40
Hypertension, diabetes mellitus, atherosclerosis: clinical manifestations of metabolic syndrome X. Prospects of pharmacological treatment]. (7626978)
1995
41
A four-year follow-up study on the incidence of diabetic retinopathy in older onset diabetes mellitus. (8033526)
1994
42
Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence. (7871524)
1994
43
Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus. (8170965)
1994
44
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. (8423228)
1993
45
Diabetes mellitus and its complications in Japan. Polyol pathway and diabetic neuropathy: selective preventive effect of aldose reductase inhibitor on the experimental diabetic neuropathy]. (1837043)
1991
46
Urinary growth hormone excretion during puberty in type 1 (insulin-dependent) diabetes mellitus. (1828739)
1991
47
Amylin, islet amyloid and diabetes mellitus type II]. (2226190)
1990
48
The activity of the renin-angiotensin-aldosterone system before and during submaximal bicycle exercise in relation to circulatory catecholamines in patients with type 1 (insulin-dependent) diabetes mellitus. (2184065)
1990
49
Diabetes mellitus, sarcoidosis,?necrobiosis lipoidica. (5818027)
1969
50
DIABETES MELLITUS, ADDISON'S DISEASE AND MYXEDEMA--REPORT OF TWO CASES. (14264246)
1965

Genetic Variations for Diabetes Mellitus

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Expression for genes affiliated with Diabetes Mellitus

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus

Search GEO for disease gene expression data for Diabetes Mellitus.

Pathways for genes affiliated with Diabetes Mellitus

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Sources:
29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.9SLC2A2, KCNJ11, GCK, HNF1B, PDX1, NEUROD1
2
Hide members
11.6GCK, HNF1B, PDX1, NEUROD1, IAPP, SLC2A2
311.4KCNJ11, GCK, PDX1, ABCC8, SLC2A2
411.4KCNJ11, GCK, PDX1, ABCC8, SLC2A2
5
Hide members
11.4IAPP, NEUROD1, PDX1, HNF1B, GCK
6
Hide members
11.4HGF, IL6, SLC2A4, SLC2A2, PTPRN
7
Development Leptin signaling via PI3K-dependent pathway
Hide members
11.2KCNJ11, LEP, ABCC8, SLC2A4
811.2SLC2A2, IAPP, PDX1, HNF1B
911.2SLC2A4, WFS1, NEUROD1, PDX1
10
Hide members
11.0SLC2A2, ABCC8, KCNJ11
11
Hide members
11.0SLC2A2, SLC2A4, GCK
12
Hide members
11.0GCK, SLC2A4, SLC2A2
1310.8KCNJ11, ABCC8
1410.8SLC2A2, SLC2A4

Compounds for genes affiliated with Diabetes Mellitus

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1glucose4413.7IAPP, ABCC8, SLC2A4, SLC2A2, PTPRN, LEP
2arginine4412.9KCNJ11, PTPRN, GCK, HNF1B, HGF, ABCC8
3calcium44 49 11 2415.6WFS1, CTLA4, NEUROD1, CAPN10, HGF, ABCC8
4lipid4412.5CTLA4, CAPN10, IAPP, GCK, IL6, ABCC8
5serine4412.4LEP, PDX1, CTLA4, AKR1B1, IAPP, ABCC8
6testosterone44 59 11 2415.4PLAGL1, IAPP, SLC2A4, LEP, ABCC8, HGF
7cholesterol44 28 11 2415.4LEP, HNF1B, CTLA4, ABCC8, IL6, CAPN10
8glutamate4412.3ICA1, GCK, KCNJ11, HGF, LEP, ABCC8
9sulfonylurea4412.2KCNJ11, GCK, PDX1, IAPP, ABCC8, SLC2A4
10c-peptide4412.2IAPP, GCK, KCNJ11, PTPRN, SLC2A2, LEP
11glycogen44 2413.2SLC2A4, IAPP, CAPN10, HGF, ABCC8, GCK
12creatinine4412.2SLC2A4, AKR1B1, IL6, LEP, HGF, GCK
13h2o24412.1GCK, HGF, AKR1B1, LEP, SLC2A4, IAPP
14dexamethasone44 49 28 1115.1SLC2A4, LEP, IL6, IAPP, CTLA4, HGF
15streptozotocin4412.0SLC2A4, SLC2A2, AKR1B1, IAPP, PDX1, GCK
16metformin44 49 1114.0KCNJ11, GCK, IAPP, LEP, SLC2A4, ABCC8
17retinoic acid44 2413.0SLC2A4, IL6, GCK, NEUROD1, PDX1, HGF
18indomethacin44 59 28 1115.0LEP, AKR1B1, IL6, HGF, SLC2A4, IAPP
19ly2940024412.0GCK, SLC2A4, LEP, IL6, CTLA4, HGF
20cysteine4412.0CTLA4, LEP, AKR1B1, CAPN10, IAPP, ABCC8
21potassium44 11 2413.9HGF, SLC2A2, ABCC8, CAPN10, KCNJ11, GCK
22cyclosporin a44 28 5913.9IL6, LEP, CTLA4, HGF, PTPRN, AKR1B1
23lactate4411.9GCK, HGF, SLC2A4, AKR1B1, IL6, IAPP
24katp4411.8PDX1, KCNJ11, SLC2A2, ABCC8, GCK
25glibenclamide44 28 49 5914.8IAPP, LEP, ABCC8, SLC2A4, KCNJ11
26pyruvate4411.7HGF, PDX1, GCK, SLC2A4, SLC2A2
27n acetylcysteine4411.7AKR1B1, PDX1, LEP, IL6, HGF
28incretin4411.6IAPP, GCK, PDX1, SLC2A2
29repaglinide44 49 1113.6ABCC8, KCNJ11, IAPP, NEUROD1
30wortmannin4411.6PDX1, CTLA4, LEP, SLC2A4, HGF
31nicotinamide44 1112.6PDX1, AKR1B1, HNF1B, HGF
32fructose44 1112.6GCK, AKR1B1, SLC2A2, SLC2A4
333-o-methylglucose4411.4GCK, SLC2A4, SLC2A2
34preproinsulin4411.4SLC2A2, PDX1, GCK
35i-app4411.4IAPP, PDX1, GCK
36fatty acid4411.4SLC2A4, ABCC8, LEP, GCK, HGF
37proglucagon4411.4PDX1, SLC2A2, GCK
38glimepiride44 49 1113.3ABCC8, KCNJ11, SLC2A4
39gliclazide44 49 1113.3SLC2A4, KCNJ11, ABCC8
40diazoxide44 59 28 1114.3GCK, KCNJ11, ABCC8
41tolbutamide44 49 28 1114.2ABCC8, GCK, KCNJ11
42cibenzoline4411.1ABCC8, KCNJ11
43aicar44 11 2413.1LEP, GCK, SLC2A4
44norepinephrine44 11 2413.1SLC2A4
45minoxidil44 28 1113.0ABCC8
46[3h]2-deoxyglucose2811.0SLC2A2, SLC2A4
47alloxan4411.0GCK, SLC2A2
48glycerol44 11 2412.9GCK, AKR1B1, LEP, SLC2A4
49forskolin44 49 1112.8PDX1, SLC2A2
50abatacept44 1111.7IL6, CTLA4

GO Terms for genes affiliated with Diabetes Mellitus

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16Gene Ontology
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Biological processes related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1endocrine pancreas developmentGO:03101812.1IAPP, HNF1B, GCK, NEUROD1, PDX1, SLC2A2
2regulation of insulin secretionGO:05079611.9GCK, KCNJ11, SLC2A2, ABCC8, NEUROD1, LEP
3positive regulation of transcription from RNA polymerase II promoterGO:04594411.8PLAGL1, PDX1, HGF, HNF1B, NEUROD1, IL6
4glucose homeostasisGO:04259311.7GCK, SLC2A4, NEUROD1, PDX1, WFS1
5carbohydrate metabolic processGO:00597511.7SLC2A2, ABCC8, AKR1B1, GCK, SLC2A4
6insulin secretionGO:03007311.5PDX1, NEUROD1, LEP, HNF1B
7energy reserve metabolic processGO:00611211.5ABCC8, KCNJ11, LEP, SLC2A2
8positive regulation of insulin secretionGO:03202411.3PDX1, CAPN10, GCK
9hexose transportGO:00864511.3SLC2A2, SLC2A4, GCK
10response to insulin stimulusGO:03286811.3LEP, PTPRN, IL6
11cellular response to insulin stimulusGO:03286911.2GCK, CAPN10, SLC2A4
12positive regulation of apoptotic processGO:04306511.2CTLA4, CAPN10, NEUROD1, IL6
13response to glucose stimulusGO:00974911.2PTPRN, HNF1B, NEUROD1
14glucose transportGO:01575811.2SLC2A2, SLC2A4, GCK
15detection of glucoseGO:05159411.1PDX1, GCK
16positive regulation of STAT protein import into nucleusGO:200036611.1LEP, IL6
17response to drugGO:04249311.1NEUROD1, IL6, KCNJ11, PDX1
18negative regulation of type B pancreatic cell apoptotic processGO:200067511.1NEUROD1, WFS1
19negative regulation of gluconeogenesisGO:04572111.0IL6, GCK
20neurological system processGO:05087710.9WFS1, KCNJ11
21nitric oxide mediated signal transductionGO:00726310.8PDX1, NEUROD1
22glucose metabolic processGO:00600610.7LEP, PDX1, KCNJ11

Molecular functions related to Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1D-glucose transmembrane transporter activityGO:05505610.8SLC2A2, SLC2A4

Products for genes affiliated with Diabetes Mellitus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetes Mellitus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet