MCID: DBT009
MIFTS: 74

Diabetes Mellitus malady

Genetic diseases, Metabolic diseases, Rare diseases, Endocrine diseases categories
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Summaries for Diabetes Mellitus

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MedlinePlus:33 Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. glucose comes from the foods you eat. insulin is a hormone that helps the glucose get into your cells to give them energy. with type 1 diabetes, your body does not make insulin. with type 2 diabetes, the more common type, your body does not make or use insulin well. without enough insulin, the glucose stays in your blood. you can also have prediabetes. this means that your blood sugar is higher than normal but not high enough to be called diabetes. having prediabetes puts you at a higher risk of getting type 2 diabetes. over time, having too much glucose in your blood can cause serious problems. it can damage your eyes, kidneys, and nerves. diabetes can also cause heart disease, stroke and even the need to remove a limb. pregnant women can also get diabetes, called gestational diabetes. a blood test can show if you have diabetes. exercise, weight control and sticking to your meal plan can help control your diabetes. you should also monitor your glucose level and take medicine if prescribed. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and type 1 diabetes mellitus. An important gene associated with Diabetes Mellitus is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Dichloroethylene metabolism and Insulin-mediated glucose transport. The drug chromium picolinate and the compounds preproinsulin and incretin have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Novus Biologicals:45 Diabetes is a disease in which the body does not produce or properly use insulin. There are four major types of diabetes: Type 1, Type 2, Gestational and Pre-Diabetes. Type 1 diabetes, previously known as juvenile diabetes, is an autoimmune disease resulting when one's own immune system destroys insulin-producing beta cells in the pancreas. This causes the pancreas to produce little or no insulin. In type 2 diabetes, the body either does not produce enough insulin or beta cells ignore insulin. Gestational diabetes refers to high glucose levels caused by pregnancy. Pre-diabetes is a condition in which blood glucose levels are high, but not high enough for the diagnosis of type 2 diabetes.

Wikipedia:65 Diabetes mellitus (DM), also known as simply diabetes, is a group of metabolic diseases in which there... more...

Description from OMIM:46 222100

Aliases & Classifications for Diabetes Mellitus

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Related Diseases for Diabetes Mellitus

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Diseases in the Type 1 Diabetes Mellitus family:

diabetes mellitus Type 2 Diabetes Mellitus

Diseases related to Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1614)
idRelated DiseaseScoreTop Affiliating Genes
1type 2 diabetes mellitus33.3KCNJ11, TNDM
2type 1 diabetes mellitus32.5INS, PTPRN, HNF1A, HNF4A, GCK, CTLA4
3neonatal diabetes mellitus32.3SLC2A2, GCK, PDX1, HNF1B, PLAGL1, INS
4permanent neonatal diabetes mellitus32.2KCNJ11, TNDM
5gestational diabetes32.2SLC2A4, GCK, HNF4A, HNF1A, PTPRN, INS
6hypoglycemia31.9ABCC8, KCNJ11, INS, HNF4A, GCK, SLC2A4
7diabetic ketoacidosis31.9INS, CTLA4
8insulin resistance31.8ABCC8, INS, IL6, HNF1B, HNF1A, HNF4A
9obesity31.8ABCC8, KCNJ11, INS, IL6, HNF1A, HNF4A
10glucose intolerance31.8INS, PDX1, GCK, SLC2A4
11diabetes mellitus, 6q24-related transient neonatal31.7PLAGL1, HYMAI
12hepatitis31.6CTLA4, HNF4A, HGF
13hyperinsulinism31.6ABCC8, KCNJ11, INS, GCK
14pancreatic agenesis31.5PDX1
15diabetes mellitus, transient neonatal, 331.4TNDM, KCNJ11
16hyperglycemia31.2SLC2A2, SLC2A4, GCK, PDX1, HNF4A, HNF1A
17ischemia31.2SLC2A4, GCK, HGF, ABCC8
18hyperuricemia31.1GCK, HNF1B, INS
19hyperinsulinemic hypoglycemia31.1ABCC8, INS
20diabetes mellitus, permanent neonatal, with neurologic features31.1TNDM, KCNJ11
21diabetes mellitus, noninsulin-dependent31.0SLC2A2, SLC2A4, HNF4A, HNF1B, NEUROD1, ABCC8
22pancreatic cancer31.0INS, HGF, HNF4A, PDX1, SLC2A4
23maturity-onset diabetes of the young31.0HNF4A, HNF1A, HNF1B, NEUROD1, INS, KCNJ11
24metabolic syndrome x30.9INS, SLC2A4
25galactosemia30.8INS, HGF, HNF1B, HNF4A, CTLA4
26liver cirrhosis30.8HGF, HNF4A, SLC2A4
27insulinoma30.8ICA1, PTPRN, INS, KCNJ11, ABCC8, HNF1A
28beckwith-wiedemann syndrome30.7PLAGL1, ZFP57, ABCC8
29ovarian cancer30.6SLC2A4, HNF4A, HNF1B, PLAGL1
30adenocarcinoma30.5NEUROD1, HGF, HNF1B, HNF4A, PDX1, SLC2A4
31adenoma30.5INS, PLAGL1, HNF1A, HNF4A, CTLA4
32prostate cancer30.4IL6, HGF, HNF1B, HNF4A, CTLA4
33chronic kidney failure30.3HNF1B, HGF, IL6, INS
34kidney cancer30.3HGF, HNF1B, HNF1A, HNF4A, CTLA4, SLC2A4
35breast cancer30.2INS, PLAGL1, HGF, HNF1A, HNF4A, CTLA4
36endometriosis30.0IL6, HGF, HNF1B
37stomach cancer29.7SLC2A4, HNF4A, HNF1A, HGF
38liver cancer29.5INS, IL6, HGF, HNF1B, HNF1A, HNF4A
39hepatoblastoma29.4HGF, HNF1A, HNF4A
40primary hyperoxaluria29.3INS, IL6, HGF, HNF1B, HNF1A, HNF4A
41hypertension11.1
42endotheliitis11.1
43neuropathy11.0
44pancreatitis11.0
45nephrogenic diabetes insipidus11.0
46diabetic nephropathy11.0
47artery disease11.0
48diabetic polyneuropathy10.9
49transient neonatal diabetes mellitus10.9
50atherosclerosis10.9

Graphical network of the top 20 diseases related to Diabetes Mellitus:



Diseases related to diabetes mellitus

Symptoms for Diabetes Mellitus

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Clinical features from OMIM:

222100

Drugs & Therapeutics for Diabetes Mellitus

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Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus

Search NIH Clinical Center for Diabetes Mellitus

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Diabetes Mellitus

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Anatomical Context for Diabetes Mellitus

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MalaCards organs/tissues related to Diabetes Mellitus:

32
Heart, Endothelial, Kidney, Testes, Pancreas, Thyroid, Liver, Bone, Eye, Skeletal muscle, Monocytes, Brain, Pancreatic islet, T cells, Placenta, Skin, Ovary, Pituitary, Adipocyte, Neutrophil, Lung, Breast, Prostate, B cells, Colon, Retina, Smooth muscle, Bone marrow, Small intestine, Myeloid, Pons, Whole blood, Spleen, Thymus, Cortex, Spinal cord, Testis, Nk cells, Hypothalamus, Tongue

Animal Models for Diabetes Mellitus or affiliated genes

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Publications for Diabetes Mellitus

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Articles related to Diabetes Mellitus:

(show top 50)    (show all 7873)
idTitleAuthorsYear
1
Mutilating fingertip ulcers in uncontrolled type 1 diabetes mellitus. (23887501)
2014
2
Nephron filtration rate and proximal tubular fluid reabsorption in the Akita mouse model of type I diabetes mellitus. (24358878)
2013
3
Albuminuria and management of type 2 diabetes mellitus. (23880799)
2013
4
Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: a clinical study. (23678391)
2013
5
Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial. (24169612)
2013
6
Type 2 diabetes mellitus and invokana: an FDA approved drug. (24160357)
2013
7
Glycated albumin versus glycated hemoglobin as glycemic indicator in hemodialysis patients with diabetes mellitus: variables that influence. (23538348)
2013
8
The prevalence of orthostatic hypotension in type 2 diabetes mellitus patients in a diabetic clinic in Enugu South-East Nigeria. (24180143)
2013
9
Insulin pump: A popular device for management of type 1 diabetes mellitus. (24381902)
2013
10
Preliminary results of pinpoint plantar long-wavelength infrared light irradiation on blood glucose, insulin and stress hormones in patients with type 2 diabetes mellitus. (24204095)
2013
11
Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta. (23954530)
2013
12
Lipids and lipoprotein ratios: contribution to carotid intima media thickness in adolescents and young adults with type 2 diabetes mellitus. (24079285)
2013
13
Circadian clock gene expression is impaired in gestational diabetes mellitus. (23323702)
2013
14
Factors related to nephrotic-range proteinuria in late-stage chronic kidney disease patients with diabetes mellitus. (23355027)
2013
15
An association between gestational diabetes mellitus and long-term maternal cardiovascular morbidity. (23749791)
2013
16
Plasma adrenomedullin and subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus. (22971508)
2012
17
Clinical profiles and long-term outcomes of patients with pancreatic ductal adenocarcinoma and diabetes mellitus. (22423386)
2012
18
Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. (22119899)
2012
19
Association of interleukin-4 promoter polymorphisms in Taiwanese patients with type 2 diabetes mellitus. (20580039)
2010
20
Pathophysiology of diabetes mellitus in Cushing's syndrome. (20829623)
2010
21
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
22
Exercise training ameliorates the effects of rosiglitazone on traditional and novel cardiovascular risk factors in patients with type 2 diabetes mellitus. (19922961)
2010
23
Customized cell-based treatment options to combat autoimmunity and restore beta-cell function in type 1 diabetes mellitus: current protocols and future perspectives. (20217518)
2010
24
Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management. (20107300)
2010
25
Idiopathic sudden sensorineural hearing loss: evolution in the presence of hypertension, diabetes mellitus and dyslipidemias. (20658017)
2010
26
Pleiotropic effects of mitiglinide in type 2 diabetes mellitus. (20146890)
2009
27
Long-term pioglitazone therapy improves arterial stiffness in patients with type 2 diabetes mellitus. (19446110)
2009
28
Is there a need for dietary measures to further reduce LDL cholesterol in patients with type II diabetes mellitus on statin therapy? (18684421)
2008
29
Miglitol increases the adiponectin level and decreases urinary albumin excretion in patients with type 2 diabetes mellitus. (17950094)
2007
30
The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. (17578587)
2007
31
Effects of carvedilol versus metoprolol on endothelial function and oxidative stress in patients with type 2 diabetes mellitus. (17586413)
2007
32
Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus. (16513827)
2006
33
Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults. (16061833)
2005
34
Superior segmental optic nerve hypoplasia and diabetes mellitus. (15866063)
2005
35
Long-term treatment with nifedipine modulates procoagulant marker and C-C chemokine in hypertensive patients with type 2 diabetes mellitus. (15668187)
2005
36
High serum interleukin-18 concentrations in patients with coronary artery disease and type 2 diabetes mellitus. (16266856)
2005
37
Adiponectin and risk of new-onset diabetes mellitus after kidney transplantation. (15257035)
2004
38
Enhanced leukocyte-platelet cross-talk in Type 1 diabetes mellitus: relationship to microangiopathy. (14717967)
2004
39
Olanzapine-induced diabetes mellitus]. (12224043)
2002
40
Analysis of slc19a2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in pima indians. (11286512)
2001
41
Prediction of insulin-dependent diabetes mellitus in children of first-degree relatives of diabetic patients]. (11678027)
2001
42
Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization. (10333057)
1999
43
Clinical efficacy of acarbose in diabetes mellitus: a critical review of controlled trials. (9805641)
1998
44
The association between retinopathy, nephropathy, cardiovascular disease and long-term metabolic control in type 1 diabetes mellitus: a 5 year follow-up study of 442 adult patients in routine care. (9179466)
1997
45
Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. (9056694)
1997
46
Drug treatment of non-insulin-dependent diabetes mellitus in the 1990s. Achievements and future developments. (9279500)
1997
47
Salivary peroxidase activity in whole saliva of patients with insulin-dependent (type-1) diabetes mellitus. (8891941)
1996
48
Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus. (7853952)
1995
49
Population analysis of protection by HLA-DR and DQ genes from insulin-dependent diabetes mellitus in Swedish children with insulin-dependent diabetes and controls. (8597561)
1995
50
Islet amyloid polypeptide (IAPP) secretion from islet cells and its plasma concentration in patients with non-insulin-dependent diabetes mellitus. (1541240)
1992

Variations for Diabetes Mellitus

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Clinvar genetic disease variations for Diabetes Mellitus:

6
id Gene Name Type Significance SNP ID Assembly Location
1HNF1ANM_000545.5(HNF1A): c.608G> A (p.Arg203His)single nucleotide variantLikely pathogenicGRCh37Chr 12, 121431404: 121431404
2HNF1ANM_000545.5(HNF1A): c.872dupC (p.Gly292Argfs)duplicationPathogenicGRCh37Chr 12, 121432125: 121432125

Expression for genes affiliated with Diabetes Mellitus

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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus

Search GEO for disease gene expression data for Diabetes Mellitus.

Pathways for genes affiliated with Diabetes Mellitus

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Pathways related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3HNF4A, HNF1A
210.3SLC2A4, INS
3
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
10.3INS, IL6, SLC2A4
4
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
10.3INS, IL6, SLC2A4
510.3SLC2A4, KCNJ11, ABCC8
610.3GCK, IL6, NEUROD1
7
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
10.3SLC2A2, GCK, INS
8
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
10.2SLC2A2, SLC2A4, GCK
9
Show member pathways
10.2SLC2A2, SLC2A4, GCK
1010.2HNF4A, SLC2A4, SLC2A2
1110.2INS, IL6, HNF1A, SLC2A4
12
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
10.2INS, HGF, GCK, SLC2A4
13
Show member pathways
10.2ABCC8, KCNJ11, INS, SLC2A2
1410.1INS, HNF1B, HNF1A, PDX1, SLC2A2
15
Show member pathways
10.1CTLA4, IL6, ICA1, PTPRN, INS
16
Show member pathways
10.1INS, NEUROD1, HNF4A, GCK, SLC2A2
17
Show member pathways
10.1ABCC8, KCNJ11, INS, PDX1, GCK, SLC2A2
1810.0INS, NEUROD1, HNF1A, HNF4A, PDX1, SLC2A4
19
Show member pathways
10.0PTPRN, IL6, HGF, HNF4A, SLC2A4, SLC2A2
209.9SLC2A2, GCK, PDX1, HNF4A, HNF1A, INS
21
Show member pathways
9.9HNF1A, HNF1B, NEUROD1, INS, HNF4A, PDX1
22
Show member pathways
9.8INS, NEUROD1, HNF1B, HNF1A, HNF4A, PDX1
23
Show member pathways
9.7SLC2A2, SLC2A4, GCK, PDX1, HNF4A, HNF1A

Compounds for genes affiliated with Diabetes Mellitus

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Compounds related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1preproinsulin4410.6GCK, SLC2A2, PDX1, INS
2incretin4410.6SLC2A2, GCK, PDX1, INS
3repaglinide50 44 1112.6ABCC8, KCNJ11, INS, NEUROD1
43-o-methylglucose4410.6SLC2A4, GCK, SLC2A2
5minoxidil44 28 1112.6ABCC8, HGF, KCNJ11
6gliclazide44 50 1112.6ABCC8, KCNJ11, INS, SLC2A4
7i-app4410.6INS, PDX1, GCK
8tolbutamide44 28 50 1113.6INS, KCNJ11, HNF1A, ABCC8, GCK
9glimepiride44 50 1112.6SLC2A4, ABCC8, KCNJ11, INS
10diazoxide44 61 28 1113.6TNDM, GCK, KCNJ11, ABCC8, INS
11nicotinamide44 1111.6INS, HNF1B, PDX1, HGF
12metformin44 50 1112.6GCK, INS, KCNJ11, ABCC8, SLC2A4
13glibenclamide44 28 50 6113.5KCNJ11, ABCC8, SLC2A4, INS, TNDM
14phosphoenolpyruvate44 1111.5SLC2A2, SLC2A4, HNF4A, HNF1A, GCK
15cibenzoline4410.5ABCC8, KCNJ11
16katp4410.5INS, KCNJ11, ABCC8, SLC2A2, PDX1, GCK
17proglucagon4410.5SLC2A2, PDX1, GCK
182-deoxyglucose44 1111.5SLC2A2, INS, SLC2A4, GCK
19streptozotocin4410.5GCK, PDX1, HGF, SLC2A2, SLC2A4, INS
20nnmt4410.5HNF1B, HNF1A
21ly2940024410.5SLC2A4, INS, IL6, HGF, GCK, CTLA4
22sterol4410.5SLC2A2, HNF4A, HNF1A, SLC2A4, GCK
23potassium44 24 1112.4SLC2A2, GCK, HNF1A, HGF, KCNJ11, ABCC8
24pyruvate4410.4HGF, GCK, SLC2A4, PDX1, HNF1A, HNF4A
25thymidine44 2411.4HNF4A, PDX1, HNF1A, HGF, IL6, CTLA4
26glycogen44 2411.4HGF, ABCC8, SLC2A2, HNF4A, GCK, SLC2A4
27fatty acid4410.4GCK, HNF4A, HNF1A, HGF, INS, ABCC8
28indomethacin44 28 61 1113.4IL6, SLC2A4, HNF4A, HNF1A, HGF
29sulfonylurea4410.4SLC2A4, GCK, PDX1, HNF1A, INS, SLC2A2
30creatinine4410.4HGF, INS, HNF1A, SLC2A4, IL6, GCK
31testosterone44 61 24 1113.4HNF4A, ABCC8, HGF, PLAGL1, IL6, INS
32cholesterol44 28 24 1113.4HNF1B, IL6, INS, ABCC8, HNF4A, CTLA4
33dexamethasone44 50 28 1113.4IL6, INS, CTLA4, GCK, HNF1A, HNF4A
34c-peptide4410.4INS, PTPRN, HNF1A, PDX1, GCK, KCNJ11
35wortmannin4410.4HGF, PDX1, CTLA4, SLC2A4, INS
36leucine4410.3HNF4A, SLC2A2, GCK, HNF1A, KCNJ11, ABCC8
37alanine4410.3IL6, HGF, SLC2A4, INS, CTLA4, GCK
38lipid4410.3HGF, ABCC8, INS, IL6, SLC2A4, GCK
39arginine4410.3GCK, ABCC8, KCNJ11, SLC2A2, INS, PTPRN
40retinoic acid44 2411.3NEUROD1, IL6, HGF, HNF1B, HNF1A, HNF4A
41glutamate4410.3ICA1, INS, KCNJ11, ABCC8, PTPRN, HNF4A
42oligonucleotide4410.2HNF4A, GCK, SLC2A2, HNF1B, PDX1, HNF1A
43glycerol44 24 1112.2SLC2A4, GCK, INS, HNF4A
44serine4410.2SLC2A4, CTLA4, GCK, INS, ABCC8, HGF
45glutamine4410.2KCNJ11, GCK, HNF4A, HNF1A, HGF
46aicar44 24 1112.2SLC2A4, GCK, INS
47tyrosine4410.2HNF1A, INS, SLC2A4, ABCC8, PTPRN, ICA1
48phosphatidylinositol4410.1CTLA4, HNF4A, PDX1, INS, SLC2A4, HGF
49glucose449.9SLC2A4, ABCC8, KCNJ11, GCK, PDX1, HNF4A
50lactate449.9INS, GCK, HGF, SLC2A4, IL6

GO Terms for genes affiliated with Diabetes Mellitus

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Biological processes related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of pronephros sizeGO:03556510.7HNF1A, HNF1B
2detection of glucoseGO:05159410.6GCK, PDX1
3negative regulation of gluconeogenesisGO:04572110.6GCK, IL6, INS
4glucose importGO:04632310.6SLC2A4, HNF1A
5positive regulation of transcription initiation from RNA polymerase II promoterGO:06026110.6HNF1B, HNF1A
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5HGF, IL6, INS
7insulin secretionGO:03007310.5NEUROD1, HNF1B, HNF1A, PDX1
8hexose transportGO:00864510.5SLC2A2, SLC2A4, GCK
9positive regulation of glycolytic processGO:04582110.5INS, GCK
10energy reserve metabolic processGO:00611210.5KCNJ11, ABCC8, SLC2A2, INS
11glucose transportGO:01575810.5SLC2A4, GCK, INS, SLC2A2
12response to glucoseGO:00974910.5NEUROD1, HNF4A, HNF1B, PTPRN
13positive regulation of glycogen biosynthetic processGO:04572510.5GCK, INS
14response to drugGO:04249310.4PDX1, IL6, NEUROD1, KCNJ11
15positive regulation of transcription, DNA-templatedGO:04589310.4HNF1A, HNF1B, HNF4A, IL6, NEUROD1
16glucose metabolic processGO:00600610.3INS, KCNJ11, PDX1
17glucose homeostasisGO:04259310.3HNF1A, PDX1, GCK, SLC2A4, NEUROD1, INS
18regulation of insulin secretionGO:05079610.3HNF4A, ABCC8, KCNJ11, INS, NEUROD1, SLC2A2
19carbohydrate metabolic processGO:00597510.3SLC2A4, GCK, ABCC8, SLC2A2
20positive regulation of cell differentiationGO:04559710.3INS, NEUROD1
21nitric oxide mediated signal transductionGO:00726310.3PDX1, NEUROD1
22positive regulation of transcription from RNA polymerase II promoterGO:04594410.3PDX1, NEUROD1, IL6, PLAGL1, HGF, HNF1B
23endocrine pancreas developmentGO:03101810.3SLC2A2, GCK, NEUROD1, INS, IL6, PDX1
24signal transduction involved in regulation of gene expressionGO:02301910.0HNF4A, NEUROD1
25small molecule metabolic processGO:04428110.0SLC2A2, GCK, INS, SLC2A4, KCNJ11, ABCC8

Molecular functions related to Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1D-glucose transmembrane transporter activityGO:05505610.4SLC2A4, SLC2A2
2protein heterodimerization activityGO:04698210.3PDX1, HNF1A, HNF1B, HGF, NEUROD1
3sequence-specific DNA bindingGO:04356510.2HNF4A, HNF1A, HNF1B, NEUROD1
4transcription regulatory region DNA bindingGO:04421210.2HNF1B, HNF1A, HNF4A
5sequence-specific DNA binding transcription factor activityGO:0037009.8NEUROD1, HNF1B, HNF1A, HNF4A, PDX1
6protein bindingGO:0055159.7INS, PTPRN, NEUROD1, IL6, HGF, HNF1B

Products for genes affiliated with Diabetes Mellitus

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  • Antibodies
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  • Lysates

Sources for Diabetes Mellitus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet