MCID: DBT009
MIFTS: 78

Diabetes Mellitus malady

Genetic diseases, Endocrine diseases, Rare diseases categories
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Summaries for Diabetes Mellitus

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Sources:
34MedlinePlus, 4CDC, 46Novus Biologicals, 65Wikipedia, 47OMIM, 33MalaCards
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Fully expand this MalaCard
MedlinePlus:34 Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. glucose comes from the foods you eat. insulin is a hormone that helps the glucose get into your cells to give them energy. with type 1 diabetes, your body does not make insulin. with type 2 diabetes, the more common type, your body does not make or use insulin well. without enough insulin, the glucose stays in your blood. you can also have prediabetes. this means that your blood sugar is higher than normal but not high enough to be called diabetes. having prediabetes puts you at a higher risk of getting type 2 diabetes. over time, having too much glucose in your blood can cause serious problems. it can damage your eyes, kidneys, and nerves. diabetes can also cause heart disease, stroke and even the need to remove a limb. pregnant women can also get diabetes, called gestational diabetes. a blood test can show if you have diabetes. exercise, weight control and sticking to your meal plan can help control your diabetes. you should also monitor your glucose level and take medicine if prescribed. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and type 1 diabetes mellitus. An important gene associated with Diabetes Mellitus is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Adipogenesis and FoxO signaling pathway. The drug chromium picolinate and the compounds 3-o-methylglucose and minoxidil have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related mouse phenotypes are muscle and renal/urinary system.

CDC:4 CDC's Division of Diabetes Translation translates diabetes research into daily practice to understand the impact of the disease, influence health outcomes, and improve access to quality health care.

Novus Biologicals:46 Diabetes is a disease in which the body does not produce or properly use insulin. There are four major types of diabetes: Type 1, Type 2, Gestational and Pre-Diabetes. Type 1 diabetes, previously known as juvenile diabetes, is an autoimmune disease resulting when one's own immune system destroys insulin-producing beta cells in the pancreas. This causes the pancreas to produce little or no insulin. In type 2 diabetes, the body either does not produce enough insulin or beta cells ignore insulin. Gestational diabetes refers to high glucose levels caused by pregnancy. Pre-diabetes is a condition in which blood glucose levels are high, but not high enough for the diagnosis of type 2 diabetes.

Wikipedia:65 Diabetes mellitus (DM) also known as simply diabetes, is a group of metabolic diseases in which there... more...

Description from OMIM:47 222100

Aliases & Classifications for Diabetes Mellitus

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8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 35MeSH, 27ICD9CM, 58SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases
ICD10: 25



Aliases & Descriptions:

diabetes mellitus 8 10 45 62
diabetes 8 47 34 62
diabetes nos 8


Related Diseases for Diabetes Mellitus

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Type 1 Diabetes Mellitus family:

diabetes mellitus Type 2 Diabetes Mellitus

Diseases related to Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1591)
idRelated DiseaseScoreTop Affiliating Genes
1type 2 diabetes mellitus32.7KCNJ11, TNDM
2type 1 diabetes mellitus32.4INS, PTPRN, HNF4A, GCK, CTLA4
3gestational diabetes32.1ABCC8, KCNJ11, INS, PTPRN, HNF4A, SLC2A4
4insulin resistance31.8INS, ABCC8, IAPP, IL6, SLC2A4, GCK
5obesity31.8SLC2A2, SLC2A4, GCK, HNF4A, IL6, IAPP
6neonatal diabetes mellitus31.8SLC2A2, GCK, PDX1, HNF1B, ABCC8, KCNJ11
7diabetic nephropathy31.6IAPP, INS, HNF1B
8permanent neonatal diabetes mellitus31.5INS, KCNJ11, ABCC8
9hypoglycemia31.4SLC2A2, ABCC8, INS, KCNJ11, GCK, HNF4A
10hepatitis31.3HGF, CTLA4, HNF4A
11hyperglycemia31.3HNF1B, ABCC8, KCNJ11, INS, SLC2A2, SLC2A4
12diabetic ketoacidosis31.3CTLA4, INS
13glucose intolerance31.1GCK, PDX1, SLC2A4, IAPP, INS
14ischemia30.9ABCC8, GCK, SLC2A4, HGF
15hyperinsulinism30.9GCK, KCNJ11, INS, ABCC8
16maturity-onset diabetes of the young30.9KCNJ11, INS, NEUROD1, HNF1B, HNF4A, PDX1
17pancreatic agenesis30.8PDX1
18insulinoma30.8ABCC8, KCNJ11, INS, PTPRN, IAPP, ICA1
19liver cirrhosis30.6SLC2A4, HNF4A, HGF
20pancreatic cancer30.6INS, HGF, IAPP, SLC2A4, PDX1, HNF4A
21hyperinsulinemic hypoglycemia30.5ABCC8, INS
22hyperuricemia30.5INS, HNF1B, GCK
23prostate cancer30.5HNF4A, CTLA4, HNF1B, IL6, HGF
24kidney cancer30.5HNF4A, HGF, SLC2A4, CTLA4, HNF1B
25galactosemia30.4HGF, INS, CTLA4, HNF4A, HNF1B
26diabetes mellitus, noninsulin-dependent30.4ABCC8, NEUROD1, HNF1B, HNF4A, SLC2A4, SLC2A2
27breast cancer30.4SLC2A4, SLC2A2, INS, IAPP, PLAGL1, CTLA4
28adenoma30.4HNF4A, INS, PLAGL1, CTLA4
29diabetes mellitus, permanent neonatal, with neurologic features30.4TNDM, KCNJ11
30diabetes mellitus, transient neonatal, 330.4TNDM, KCNJ11
31metabolic syndrome x30.3SLC2A4, INS
32hepatocellular carcinoma30.3IL6, HGF, SLC2A2, INS, CTLA4, HNF1B
33adenocarcinoma30.2HNF4A, PDX1, SLC2A4, IAPP, NEUROD1, HGF
34diabetes, permanent neonatal30.2TNDM, KCNJ11
35beckwith-wiedemann syndrome30.1ABCC8, PLAGL1, ZFP57
36ovarian cancer30.1HNF1B, HNF4A, PLAGL1, SLC2A4
37chronic kidney failure30.0HGF, IL6, INS, HNF1B
38endometriosis29.7HGF, HNF1B, IL6
39primary hyperoxaluria29.5HNF1B, HGF, IL6, CTLA4, INS, IAPP
40hypertension11.1
41endotheliitis11.0
42neuropathy11.0
43pancreatitis11.0
44nephrogenic diabetes insipidus11.0
45artery disease10.9
46coronary artery disease10.9
47atherosclerosis10.9
48autonomic neuropathy10.9
49transient neonatal diabetes mellitus10.9
50thyroiditis10.9

Graphical network of the top 20 diseases related to Diabetes Mellitus:



Diseases related to diabetes mellitus

Symptoms for Diabetes Mellitus

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47OMIM
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Clinical features from OMIM:

222100

Drugs & Therapeutics for Diabetes Mellitus

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus

Search NIH Clinical Center for Diabetes Mellitus

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Diabetes Mellitus

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Anatomical Context for Diabetes Mellitus

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33MalaCards
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MalaCards organs/tissues related to Diabetes Mellitus:

33
Heart, Endothelial, Kidney, Testes, Pancreas, Liver, Thyroid, Bone, Eye, Skeletal muscle, Monocytes, Brain, Pancreatic islet, T cells, Skin, Ovary, Placenta, Adipocyte, Pituitary, Lung, Breast, B cells, Prostate, Colon, Smooth muscle, Retina, Pons, Myeloid, Bone marrow, Small intestine, Whole blood, Tongue, Hypothalamus, Spleen, Spinal cord, Thymus, Cortex, Testis

Animal Models for Diabetes Mellitus or affiliated genes

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37MGI
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Publications for Diabetes Mellitus

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52PubMed
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Articles related to Diabetes Mellitus:

(show top 50)    (show all 7698)
idTitleAuthorsYear
1
Mutilating fingertip ulcers in uncontrolled type 1 diabetes mellitus. (23887501)
2014
2
Nephron filtration rate and proximal tubular fluid reabsorption in the Akita mouse model of type I diabetes mellitus. (24358878)
2013
3
Albuminuria and management of type 2 diabetes mellitus. (23880799)
2013
4
Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: a clinical study. (23678391)
2013
5
Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial. (24169612)
2013
6
Type 2 diabetes mellitus and invokana: an FDA approved drug. (24160357)
2013
7
Glycated albumin versus glycated hemoglobin as glycemic indicator in hemodialysis patients with diabetes mellitus: variables that influence. (23538348)
2013
8
The prevalence of orthostatic hypotension in type 2 diabetes mellitus patients in a diabetic clinic in Enugu South-East Nigeria. (24180143)
2013
9
Insulin pump: A popular device for management of type 1 diabetes mellitus. (24381902)
2013
10
Preliminary results of pinpoint plantar long-wavelength infrared light irradiation on blood glucose, insulin and stress hormones in patients with type 2 diabetes mellitus. (24204095)
2013
11
Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta. (23954530)
2013
12
Lipids and lipoprotein ratios: contribution to carotid intima media thickness in adolescents and young adults with type 2 diabetes mellitus. (24079285)
2013
13
Circadian clock gene expression is impaired in gestational diabetes mellitus. (23323702)
2013
14
Factors related to nephrotic-range proteinuria in late-stage chronic kidney disease patients with diabetes mellitus. (23355027)
2013
15
An association between gestational diabetes mellitus and long-term maternal cardiovascular morbidity. (23749791)
2013
16
Plasma adrenomedullin and subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus. (22971508)
2012
17
Clinical profiles and long-term outcomes of patients with pancreatic ductal adenocarcinoma and diabetes mellitus. (22423386)
2012
18
Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. (22119899)
2012
19
Association of interleukin-4 promoter polymorphisms in Taiwanese patients with type 2 diabetes mellitus. (20580039)
2010
20
Pathophysiology of diabetes mellitus in Cushing's syndrome. (20829623)
2010
21
The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease. (21058922)
2010
22
Exercise training ameliorates the effects of rosiglitazone on traditional and novel cardiovascular risk factors in patients with type 2 diabetes mellitus. (19922961)
2010
23
Customized cell-based treatment options to combat autoimmunity and restore beta-cell function in type 1 diabetes mellitus: current protocols and future perspectives. (20217518)
2010
24
Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management. (20107300)
2010
25
Idiopathic sudden sensorineural hearing loss: evolution in the presence of hypertension, diabetes mellitus and dyslipidemias. (20658017)
2010
26
Pleiotropic effects of mitiglinide in type 2 diabetes mellitus. (20146890)
2009
27
Long-term pioglitazone therapy improves arterial stiffness in patients with type 2 diabetes mellitus. (19446110)
2009
28
Is there a need for dietary measures to further reduce LDL cholesterol in patients with type II diabetes mellitus on statin therapy? (18684421)
2008
29
Miglitol increases the adiponectin level and decreases urinary albumin excretion in patients with type 2 diabetes mellitus. (17950094)
2007
30
The interactive role of type 2 diabetes mellitus and E-selectin S128R mutation on susceptibility to coronary heart disease. (17578587)
2007
31
Effects of carvedilol versus metoprolol on endothelial function and oxidative stress in patients with type 2 diabetes mellitus. (17586413)
2007
32
Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus. (16513827)
2006
33
Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults. (16061833)
2005
34
Superior segmental optic nerve hypoplasia and diabetes mellitus. (15866063)
2005
35
Long-term treatment with nifedipine modulates procoagulant marker and C-C chemokine in hypertensive patients with type 2 diabetes mellitus. (15668187)
2005
36
High serum interleukin-18 concentrations in patients with coronary artery disease and type 2 diabetes mellitus. (16266856)
2005
37
Adiponectin and risk of new-onset diabetes mellitus after kidney transplantation. (15257035)
2004
38
Enhanced leukocyte-platelet cross-talk in Type 1 diabetes mellitus: relationship to microangiopathy. (14717967)
2004
39
Olanzapine-induced diabetes mellitus]. (12224043)
2002
40
Analysis of slc19a2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in pima indians. (11286512)
2001
41
Prediction of insulin-dependent diabetes mellitus in children of first-degree relatives of diabetic patients]. (11678027)
2001
42
Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization. (10333057)
1999
43
Clinical efficacy of acarbose in diabetes mellitus: a critical review of controlled trials. (9805641)
1998
44
The association between retinopathy, nephropathy, cardiovascular disease and long-term metabolic control in type 1 diabetes mellitus: a 5 year follow-up study of 442 adult patients in routine care. (9179466)
1997
45
Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. (9056694)
1997
46
Drug treatment of non-insulin-dependent diabetes mellitus in the 1990s. Achievements and future developments. (9279500)
1997
47
Salivary peroxidase activity in whole saliva of patients with insulin-dependent (type-1) diabetes mellitus. (8891941)
1996
48
Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus. (7853952)
1995
49
Population analysis of protection by HLA-DR and DQ genes from insulin-dependent diabetes mellitus in Swedish children with insulin-dependent diabetes and controls. (8597561)
1995
50
Islet amyloid polypeptide (IAPP) secretion from islet cells and its plasma concentration in patients with non-insulin-dependent diabetes mellitus. (1541240)
1992

Variations for Diabetes Mellitus

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Sources:
1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Diabetes Mellitus:

1
id Gene Name Type Significance SNP ID Assembly Location
1HNF1ANM_000545.5(HNF1A): c.872dupC (p.Gly292Argfs)duplicationPathogenic/card/diabetes_mellitusGRCh37Chr 12, 121432125: 121432125

Expression for genes affiliated with Diabetes Mellitus

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus

Search GEO for disease gene expression data for Diabetes Mellitus.

Pathways for genes affiliated with Diabetes Mellitus

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 54R&D Systems, 60Thomson Reuters, 53QIAGEN, 55Reactome, 12EMD Millipore, 5Cell Signaling Technology, 51PharmGKB
See all sources

Pathways related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2SLC2A4, IL6, INS
2
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
10.2INS, IL6, SLC2A4
3
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
10.2INS, IL6, SLC2A4
410.2ABCC8, KCNJ11, SLC2A4
510.2GCK, IL6, NEUROD1
6
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
10.2SLC2A2, GCK, INS
7
Show member pathways
10.2GCK, SLC2A4, SLC2A2
8
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
10.2GCK, SLC2A4, SLC2A2
910.2SLC2A2, SLC2A4, HNF4A
10
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
10.1SLC2A4, GCK, HGF, INS
11
Show member pathways
10.1ABCC8, KCNJ11, INS, SLC2A2
12
Show member pathways
10.0INS, NEUROD1, HNF4A, GCK, SLC2A2
13
Show member pathways
10.0CTLA4, IL6, ICA1, PTPRN, INS
1410.0INS, IAPP, HNF1B, PDX1, SLC2A2
15
Show member pathways
9.9ABCC8, KCNJ11, INS, PDX1, GCK, SLC2A2
16
Show member pathways
9.9PTPRN, IL6, HGF, HNF4A, SLC2A4, SLC2A2
179.9INS, NEUROD1, WFS1, HNF4A, PDX1, SLC2A4
189.8ABCC8, KCNJ11, INS, HNF4A, PDX1, GCK
19
Show member pathways
9.7INS, NEUROD1, IAPP, HNF1B, HNF4A, PDX1
20
Show member pathways
9.5INS, NEUROD1, IAPP, HNF1B, HNF4A, PDX1
21
Show member pathways
9.5SLC2A2, ABCC8, KCNJ11, SLC2A4, GCK, PDX1

Compounds for genes affiliated with Diabetes Mellitus

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB
See all sources

Compounds related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
13-o-methylglucose4510.5GCK, SLC2A4, SLC2A2
2minoxidil45 29 1112.5ABCC8, KCNJ11, HGF
3gliclazide45 51 1112.5SLC2A4, KCNJ11, ABCC8, INS
4preproinsulin4510.5INS, SLC2A2, PDX1, GCK
5tolbutamide45 29 51 1113.5KCNJ11, GCK, INS, ABCC8
6glimepiride45 51 1112.5INS, SLC2A4, ABCC8, KCNJ11
7i-app4510.5PDX1, IAPP, INS, GCK
8nicotinamide45 1111.5HGF, HNF1B, INS, PDX1
9cibenzoline4510.5KCNJ11, ABCC8
10proglucagon4510.4SLC2A2, PDX1, GCK
11diazoxide45 61 29 1113.4TNDM, KCNJ11, INS, GCK, ABCC8
12repaglinide51 45 1112.4NEUROD1, INS, IAPP, KCNJ11, ABCC8
13phosphoenolpyruvate45 1111.4SLC2A2, SLC2A4, GCK, HNF4A
142-deoxyglucose45 1111.4INS, GCK, SLC2A4, SLC2A2
15incretin4510.4GCK, PDX1, IAPP, SLC2A2, INS
16katp4510.4ABCC8, KCNJ11, INS, GCK, SLC2A2, PDX1
17metformin45 51 1112.3GCK, IAPP, ABCC8, SLC2A4, INS, KCNJ11
18ly2940024510.3GCK, HGF, SLC2A4, CTLA4, IL6, INS
19glibenclamide45 29 51 6113.3TNDM, ABCC8, IAPP, SLC2A4, INS, KCNJ11
20pyruvate4510.3HNF4A, GCK, HGF, SLC2A4, PDX1, SLC2A2
21fatty acid4510.3HGF, SLC2A4, HNF4A, GCK, INS, ABCC8
22lactate4510.2HGF, IAPP, GCK, IL6, INS, SLC2A4
23indomethacin45 29 61 1113.2SLC2A4, HNF4A, HGF, IL6, IAPP
24streptozotocin4510.2HGF, INS, PDX1, SLC2A4, SLC2A2, GCK
25thymidine45 2411.2HGF, PDX1, HNF4A, IL6, IAPP, CTLA4
26wortmannin4510.2PDX1, SLC2A4, CTLA4, HGF, INS
27norepinephrine45 24 1112.2SLC2A4, HGF, IL6, INS, IAPP
28creatinine4510.2IL6, SLC2A4, INS, HGF, IAPP, GCK
29sulfonylurea4510.1ABCC8, INS, IAPP, PDX1, GCK, SLC2A4
30cholesterol45 29 24 1113.1IAPP, CTLA4, GCK, HNF4A, HNF1B, IL6
31alanine4510.1CTLA4, SLC2A4, GCK, INS, IL6, HGF
32testosterone45 61 24 1113.1ABCC8, IL6, HNF4A, PLAGL1, INS, IAPP
33dexamethasone45 51 29 1113.1CTLA4, SLC2A4, HNF4A, HGF, IL6, INS
34glycogen45 2411.1HGF, IAPP, HNF4A, SLC2A4, ABCC8, SLC2A2
35ibmx45 61 2912.1SLC2A4, SLC2A2, IAPP, INS
36c-peptide4510.1PDX1, IAPP, PTPRN, INS, KCNJ11, HNF4A
37retinoic acid45 2411.1HGF, SLC2A4, PDX1, GCK, NEUROD1, IL6
38sterol4510.1HNF4A, SLC2A2, SLC2A4, GCK
39lipid4510.0CTLA4, SLC2A4, GCK, HNF4A, IL6, IAPP
40potassium45 24 1112.0ABCC8, SLC2A2, GCK, HGF, KCNJ11
41atp45 2911.0ABCC8, KCNJ11, SLC2A2, GCK, HGF, IAPP
42glutamate4510.0PTPRN, GCK, CTLA4, HNF4A, HGF, ICA1
43serine4510.0PDX1, ABCC8, SLC2A4, CTLA4, GCK, HNF4A
44oligonucleotide4510.0SLC2A2, GCK, PDX1, HNF4A, HNF1B, IAPP
45arginine459.9GCK, HNF1B, IAPP, ABCC8, SLC2A2, KCNJ11
46tyrosine459.9PTPRN, CTLA4, HNF4A, IL6, HGF, ICA1
47calcium45 51 24 1112.9GCK, CTLA4, PDX1, HNF4A, HGF, WFS1
48forskolin45 51 1111.8SLC2A4, GCK, PDX1, IAPP, SLC2A2
49phosphatidylinositol459.6SLC2A4, CTLA4, PDX1, HNF4A, HGF, INS
50glucose459.5HNF4A, NEUROD1, HNF1B, IL6, IAPP, PTPRN

GO Terms for genes affiliated with Diabetes Mellitus

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Sources:
16Gene Ontology
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Biological processes related to Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1detection of glucoseGO:05159410.6GCK, PDX1
2negative regulation of gluconeogenesisGO:04572110.6INS, IL6, GCK
3neurological system processGO:05087710.5WFS1, KCNJ11
4negative regulation of type B pancreatic cell apoptotic processGO:200067510.5WFS1, NEUROD1
5positive regulation of glycolytic processGO:04582110.5GCK, INS
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.5INS, IL6, HGF
7insulin secretionGO:03007310.5NEUROD1, HNF1B, PDX1
8positive regulation of glycogen biosynthetic processGO:04572510.4GCK, INS
9hexose transportGO:00864510.4SLC2A2, SLC2A4, GCK
10energy reserve metabolic processGO:00611210.4SLC2A2, INS, KCNJ11, ABCC8
11glucose transportGO:01575810.4INS, GCK, SLC2A4, SLC2A2
12response to glucoseGO:00974910.4HNF4A, HNF1B, NEUROD1, PTPRN
13nitric oxide mediated signal transductionGO:00726310.3PDX1, NEUROD1
14response to drugGO:04249310.3KCNJ11, NEUROD1, IL6, PDX1
15glucose metabolic processGO:00600610.3KCNJ11, INS, PDX1
16positive regulation of cell differentiationGO:04559710.3NEUROD1, INS
17carbohydrate metabolic processGO:00597510.3ABCC8, GCK, SLC2A4, SLC2A2
18signal transduction involved in regulation of gene expressionGO:02301910.2HNF4A, NEUROD1
19regulation of insulin secretionGO:05079610.2GCK, HNF4A, NEUROD1, INS, KCNJ11, ABCC8
20positive regulation of transcription from RNA polymerase II promoterGO:04594410.1NEUROD1, IL6, PLAGL1, HGF, HNF1B, HNF4A
21glucose homeostasisGO:04259310.1INS, NEUROD1, WFS1, HNF4A, PDX1, GCK
22endocrine pancreas developmentGO:0310189.9SLC2A2, INS, NEUROD1, IAPP, IL6, HNF1B
23small molecule metabolic processGO:0442819.9ABCC8, KCNJ11, INS, GCK, SLC2A4, SLC2A2
24positive regulation of transcription, DNA-templatedGO:0458939.8NEUROD1, IL6, HNF1B, HNF4A

Molecular functions related to Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:04698210.1PDX1, HNF1B, HGF, NEUROD1
2D-glucose transmembrane transporter activityGO:05505610.0SLC2A2, SLC2A4

Products for genes affiliated with Diabetes Mellitus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetes Mellitus

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet