MCID: DBT013
MIFTS: 20

Diabetes Mellitus, 6q24-Related Transient Neonatal malady

Genetic diseases, Rare diseases, Endocrine diseases, Metabolic diseases, Fetal diseases categories

Aliases & Classifications for Diabetes Mellitus, 6q24-Related Transient Neonatal

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Aliases & Descriptions for Diabetes Mellitus, 6q24-Related Transient Neonatal:

Name: Diabetes Mellitus, 6q24-Related Transient Neonatal 21 22
6q24-Related Transient Neonatal Diabetes Mellitus 23 65
Transient Neonatal Diabetes Mellitus 1 23 24
6q24-Tndm 21 23
 
Chromosome 6-Associated Transient Diabetes Mellitus 22
Diabetes Mellitus, Transient Neonatal, 1 22
Tndm Type 1 23
Tndm1 22


Classifications:



Summaries for Diabetes Mellitus, 6q24-Related Transient Neonatal

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Genetics Home Reference:23 6q24-related transient neonatal diabetes mellitus is a type of diabetes that occurs in infants. This form of diabetes is characterized by high blood sugar levels (hyperglycemia) resulting from a shortage of the hormone insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy.

MalaCards based summary: Diabetes Mellitus, 6q24-Related Transient Neonatal, also known as 6q24-related transient neonatal diabetes mellitus, is related to diabetes mellitus, transient neonatal, 1 and neonatal diabetes mellitus. An important gene associated with Diabetes Mellitus, 6q24-Related Transient Neonatal is ZFP57 (ZFP57 Zinc Finger Protein). Related mouse phenotype other.

GeneReviews summary for dmtn

Related Diseases for Diabetes Mellitus, 6q24-Related Transient Neonatal

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Graphical network of diseases related to Diabetes Mellitus, 6q24-Related Transient Neonatal:



Diseases related to diabetes mellitus, 6q24-related transient neonatal

Symptoms for Diabetes Mellitus, 6q24-Related Transient Neonatal

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Drugs & Therapeutics for Diabetes Mellitus, 6q24-Related Transient Neonatal

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Drugs for Diabetes Mellitus, 6q24-Related Transient Neonatal (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Glucagon-Like Peptide 1Phase 4652
2
GlyburideapprovedPhase 210010238-21-83488
Synonyms:
1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
10238-21-8
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
5-chloro-N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
AB00051949
AC1L1G1Q
AC1Q44V7
AKOS001487495
Abbenclamide
Adiab
Apo-Glibenclamide
Azuglucon
BIDD:GT0239
BPBio1_000344
BRD-K36927236-001-06-0
BRN 2230085
BSPBio_000312
BSPBio_001351
BSPBio_003053
Bastiverit
Benclamin
Betanase
Betanese 5
Bio-0156
Bio1_000076
Bio1_000565
Bio1_001054
Bio2_000071
Bio2_000551
C07022
C23H28ClN3O5S
CAS-10238-21-8
CBiol_001790
CHEBI:5441
CHEMBL472
CID3488
CPD000058229
Calabren
Cytagon
D00336
D005905
DB01016
Daonil
Debtan
Dia-basan
Diabeta
Diabeta (TN)
Diabiphage
Dibelet
DivK1c_000481
Duraglucon
EINECS 233-570-6
EU-0100499
Euclamin
Euglucan
Euglucon
Euglucon 5
Euglucon N
Euglykon
G 0639
G0639_SIAL
G0639_SIGMA
G2539_SIAL
GBN 5
Gen-Glybe
Gewaglucon
Gilemal
Glamide
Glibadone
Gliban
Gliben
Gliben-Puren N
Glibenbeta
Glibenclamid AL
Glibenclamid Basics
Glibenclamid Fabra
Glibenclamid Genericon
Glibenclamid Heumann
Glibenclamid Riker M
Glibenclamid Riker M.
Glibenclamid-Cophar
Glibenclamid-Ratiopharm
Glibenclamida
Glibenclamida [INN-Spanish]
Glibenclamide
Glibenclamide (JP15/INN)
Glibenclamidum
Glibenclamidum [INN-Latin]
Glibenil
Glibens
Glibesyn
Glibet
Glibetic
Glibil
Gliboral
Glicem
Glidiabet
Glimel
Glimide
Glimidstata
Glisulin
Glitisol
Glubate
Gluben
Gluco-Tablimen
Glucobene
Glucohexal
Glucolon
Glucomid
Glucoremed
Glucoven
Glyben
Glybenclamide
Glybenzcyclamide
Glyburide
Glyburide (USP)
Glyburide (micronized)
Glyburide [USAN]
 
Glycolande
Glycomin
Glynase
Glynase (TN)
HB 419
HB 420
HB-419
HB-420
HB419
HB420
HMS1361D13
HMS1568P14
HMS1791D13
HMS1922L08
HMS1989D13
HMS2089L06
HMS2093P04
HMS501I03
Hemi-Daonil
Hexaglucon
Humedia
I06-0716
IDI1_000481
IDI1_033821
KBio1_000481
KBio2_000071
KBio2_000730
KBio2_002639
KBio2_003298
KBio2_005207
KBio2_005866
KBio3_000141
KBio3_000142
KBio3_002273
KBioGR_000071
KBioGR_001897
KBioSS_000071
KBioSS_000730
LS-159295
Lederglib
Libanil
Lisaglucon
Lopac-G-0639
Lopac0_000499
MLS000069721
MLS001077262
Malix
Maninil
Med-Glionil
Melix
Micronase
Micronase (TN)
Micronized glyburide
Miglucan
MolPort-000-784-850
N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)-ethyl]benzene-sulfonyl-N -cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea
NCGC00015467-01
NCGC00015467-02
NCGC00015467-06
NCGC00015467-16
NCGC00016689-01
NCGC00023447-02
NCGC00023447-04
NCGC00023447-05
NCGC00023447-06
NCGC00023447-07
NCGC00023447-08
NCGC00023447-09
NCGC00023447-10
NCGC00023447-11
NCGC00023447-12
NINDS_000481
Nadib
Neogluconin
Norglicem 5
Normoglucon
Novo-Glyburide
Oprea1_764617
Orabetic
Pira
Praeciglucon
PresTab
Prestwick0_000316
Prestwick1_000316
Prestwick2_000316
Prestwick3_000316
Prestwick_569
Probes1_000431
Probes2_000378
Prodiabet
Renabetic
S1716_Selleck
SAM002564212
SMR000058229
SPBio_001831
SPBio_002531
SPECTRUM2300229
SR-01000000196-5
STK362992
Semi-Daonil
Semi-Euglucon
Semi-Gliben-Puren N
Semi-daonil
Spectrum2_001816
Spectrum3_001327
Spectrum4_001199
Spectrum5_001631
Spectrum_000250
Sugril
Suraben
Tiabet
Tocris-0911
U 26452
U-26452
UNII-SX6K58TVWC
UPCMLD-DP006
UPCMLD-DP006:001
UR 606
Yuglucon
ZINC00537805
glibenclamide
glyburide
3Insulin, Globin ZincPhase 24069
4insulinPhase 24069

Interventional clinical trials:

idNameStatusNCT IDPhase
1Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)Enrolling by invitationNCT02624830Phase 4
2Long-Term Sulfonylurea Response in KCNJ11 Neonatal DiabetesEnrolling by invitationNCT02624817Phase 4
3Efficacy and Safety Study of Sulfonylureas in Neonatal Diabetes MellitusCompletedNCT00610038Phase 2
4Predisposition Genes in Monogenic Diabetes (DIAMONO)CompletedNCT02634229

Search NIH Clinical Center for Diabetes Mellitus, 6q24-Related Transient Neonatal

Genetic Tests for Diabetes Mellitus, 6q24-Related Transient Neonatal

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Genetic tests related to Diabetes Mellitus, 6q24-Related Transient Neonatal:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, 6q24-Related Transient Neonatal22 ZFP57
2 Transient Neonatal Diabetes Mellitus 124

Anatomical Context for Diabetes Mellitus, 6q24-Related Transient Neonatal

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Animal Models for Diabetes Mellitus, 6q24-Related Transient Neonatal or affiliated genes

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MGI Mouse Phenotypes related to Diabetes Mellitus, 6q24-Related Transient Neonatal:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.0PLAGL1, ZFP57

Publications for Diabetes Mellitus, 6q24-Related Transient Neonatal

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Articles related to Diabetes Mellitus, 6q24-Related Transient Neonatal:

idTitleAuthorsYear
1
Diabetes Mellitus, 6q24-Related Transient Neonatal (20301706)
1993

Variations for Diabetes Mellitus, 6q24-Related Transient Neonatal

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Clinvar genetic disease variations for Diabetes Mellitus, 6q24-Related Transient Neonatal:

5
id Gene Variation Type Significance SNP ID Assembly Location
1ZFP57NM_001109809.2(ZFP57): c.783C> A (p.Cys261Ter)single nucleotide variantPathogenicrs61730328GRCh37Chr 6, 29641105: 29641105
2ZFP57NM_001109809.2(ZFP57): c.317_318delAG (p.Glu106Valfs)deletionPathogenicrs606231121GRCh38Chr 6, 29675420: 29675421
3ZFP57NM_001109809.2(ZFP57): c.1383delC (p.Tyr462Ilefs)deletionPathogenicrs606231122GRCh38Chr 6, 29672728: 29672728
4ZFP57NM_001109809.2(ZFP57): c.1372C> G (p.His458Asp)single nucleotide variantPathogenicrs79020217GRCh37Chr 6, 29640516: 29640516
5ZFP57NM_001109809.2(ZFP57): c.743G> A (p.Arg248His)single nucleotide variantPathogenicrs77625743GRCh37Chr 6, 29641145: 29641145
6ZFP57NM_001109809.2(ZFP57): c.829C> A (p.His277Asn)single nucleotide variantPathogenicrs78378398GRCh37Chr 6, 29641059: 29641059
7ZFP57NM_001109809.2(ZFP57): c.898_905delACCCAGGC (p.Thr300Terfs)deletionPathogenicrs606231123GRCh38Chr 6, 29673206: 29673213

Expression for genes affiliated with Diabetes Mellitus, 6q24-Related Transient Neonatal

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Search GEO for disease gene expression data for Diabetes Mellitus, 6q24-Related Transient Neonatal.

Pathways for genes affiliated with Diabetes Mellitus, 6q24-Related Transient Neonatal

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GO Terms for genes affiliated with Diabetes Mellitus, 6q24-Related Transient Neonatal

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Sources for Diabetes Mellitus, 6q24-Related Transient Neonatal

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet