TNDM
MCID: DBT013
MIFTS: 28

Diabetes Mellitus, 6q24-Related Transient Neonatal (TNDM) malady

Endocrine category

Summaries for Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
21Genetics Home Reference, 47OMIM, 19GeneReviews, 33MalaCards
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Genetics Home Reference:21 6q24-related transient neonatal diabetes mellitus is a type of diabetes that occurs in infants. This form of diabetes is characterized by high blood sugar levels (hyperglycemia) resulting from a shortage of the hormone insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy.

MalaCards: Diabetes Mellitus, 6q24-Related Transient Neonatal, also known as diabetes mellitus, transient neonatal, 1, is related to neonatal diabetes mellitus and permanent neonatal diabetes mellitus. An important gene associated with Diabetes Mellitus, 6q24-Related Transient Neonatal is ZFP57 (ZFP57 zinc finger protein), and among its related pathways are Regulation of Insulin Secretion and Potassium Channels. The compounds cibenzoline and nicorandil have been mentioned in the context of this disorder. Related mouse phenotype no phenotypic analysis.

Description from OMIM:47 601410,610374,610582

GeneReviews summary for dmtn

Aliases & Classifications for Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
19GeneReviews, 20GeneTests, 21Genetics Home Reference, 47OMIM, 49Orphanet, 61UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

diabetes mellitus, 6q24-related transient neonatal 19 20
diabetes mellitus, transient neonatal, 1 47 61
tndm 19 49
chromosome 6-associated transient diabetes mellitus 19
6q24-related transient neonatal diabetes mellitus 21
transient neonatal diabetes mellitus 1 21
transient neonatal diabetes mellitus 49
tndm type 1 21
6q24-tndm 21


External Ids:

ICD10 via Orphanet26 P70.2

Related Diseases for Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Diabetes Mellitus, 6q24-Related Transient Neonatal:



Diseases related to diabetes mellitus, 6q24-related transient neonatal

Clinical Features for Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
47OMIM
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Clinical features from OMIM:

601410,610374,610582

Clinical synopsis from OMIM:

601410

Drugs & Therapeutics for Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Diabetes Mellitus, 6q24-Related Transient Neonatal

Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus, 6q24-Related Transient Neonatal

Search NIH Clinical Center for Diabetes Mellitus, 6q24-Related Transient Neonatal

Search CenterWatch for Diabetes Mellitus, 6q24-Related Transient Neonatal

Genetic Tests for Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
20GeneTests
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Genetic tests related to Diabetes Mellitus, 6q24-Related Transient Neonatal:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, 6q24-related Transient Neonatal20 ZFP57

Anatomical Context for Diabetes Mellitus, 6q24-Related Transient Neonatal

Animal Models for Diabetes Mellitus, 6q24-Related Transient Neonatal or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Diabetes Mellitus, 6q24-Related Transient Neonatal:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8PLAGL1, ABCC8, KCNJ11

Publications for Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
51PubMed
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Articles related to Diabetes Mellitus, 6q24-Related Transient Neonatal:

idTitleAuthorsYear
1
Diabetes Mellitus, 6q24-Related Transient Neonatal (20301706)
1993

Genetic Variations for Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
63UniProtKB/Swiss-Prot
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Genetic disease variations for Diabetes Mellitus, 6q24-Related Transient Neonatal:

63
id Symbol AA change Variation SNP ID
1ZFP57p.Arg166HisVAR_054771
2ZFP57p.His193AsnVAR_054772
3ZFP57p.His374AspVAR_054773

Expression for genes affiliated with Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus, 6q24-Related Transient Neonatal

Search GEO for disease gene expression data for Diabetes Mellitus, 6q24-Related Transient Neonatal.

Pathways for genes affiliated with Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
54Reactome, 30KEGG, 50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Diabetes Mellitus, 6q24-Related Transient Neonatal according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1cibenzoline459.6ABCC8, KCNJ11
2nicorandil45 2910.6ABCC8, KCNJ11
3mgadp459.6ABCC8, KCNJ11
4cromakalim45 2910.6ABCC8, KCNJ11
5minoxidil45 29 1111.6KCNJ11, ABCC8
6repaglinide45 50 1111.6ABCC8, KCNJ11
7glimepiride45 50 1111.6ABCC8, KCNJ11
8gliclazide45 50 1111.5ABCC8, KCNJ11
9Glyburide119.5KCNJ11, ABCC8
10sulfonylurea459.5ABCC8, KCNJ11
11katp459.4ABCC8, KCNJ11
12diazoxide45 60 29 1112.4ABCC8, KCNJ11
13tolbutamide45 50 29 1112.3KCNJ11, ABCC8
14pip2459.3ABCC8, KCNJ11
15glibenclamide45 29 50 6012.2ABCC8, KCNJ11
16metformin45 50 1111.0ABCC8, KCNJ11

GO Terms for genes affiliated with Diabetes Mellitus, 6q24-Related Transient Neonatal

Sources:
16Gene Ontology
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Cellular components related to Diabetes Mellitus, 6q24-Related Transient Neonatal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel complexGO:0080769.3ABCC8, KCNJ11

Biological processes related to Diabetes Mellitus, 6q24-Related Transient Neonatal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1energy reserve metabolic processGO:0061129.3ABCC8, KCNJ11
2potassium ion transmembrane transportGO:0718059.2ABCC8, KCNJ11
3regulation of insulin secretionGO:0507969.0ABCC8, KCNJ11

Molecular functions related to Diabetes Mellitus, 6q24-Related Transient Neonatal according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion channel bindingGO:0443259.3ABCC8, KCNJ11

Products for genes affiliated with Diabetes Mellitus, 6q24-Related Transient Neonatal

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetes Mellitus, 6q24-Related Transient Neonatal

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet