MCID: DBT085
MIFTS: 85

Diabetes Mellitus, Insulin-Dependent malady

Genetic diseases, Rare diseases, Endocrine diseases categories

Summaries for Diabetes Mellitus, Insulin-Dependent

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NIH Rare Diseases:43 Diabetes mellitus type 1 (dm1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. dm1 can occur at any age, but usually develops by early adulthood, most often in adolescence. symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. the exact cause of dm1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. a predisposition to develop dm1 runs in families, but no known inheritance pattern exists. treatment includes blood sugar control and insulin replacement therapy. improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. if not treated, the condition can be life-threatening. over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body. last updated: 4/25/2014

MalaCards based summary: Diabetes Mellitus, Insulin-Dependent, also known as diabetes mellitus, is related to maturity-onset diabetes of the young and hyperglycemia, and has symptoms including polyuria, diabetes mellitus and heterogeneous. An important gene associated with Diabetes Mellitus, Insulin-Dependent is HNF1A (HNF1 homeobox A), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Adipogenesis. The drugs insulin and insulin, aspart, human and the compounds pha 665752 and su 11274 have been mentioned in the context of this disorder. Affiliated tissues include pancreas, eye and kidney, and related mouse phenotypes are renal/urinary system and integument.

Disease Ontology:10 A diabetes mellitus that results from the body's failure to produce insulin and has material basis in autoimmune destruction of insulin-producing beta cells of the pancreas.

Genetics Home Reference:23 Type 1 diabetes is a disorder characterized by abnormally high blood sugar levels. In this form of diabetes, specialized cells in the pancreas called beta cells stop producing insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the inability to use glucose for energy or to control the amount of sugar in the blood.

OMIM:47 The type of diabetes mellitus called IDDM is a disorder of glucose homeostasis that is characterized by susceptibility... (222100) more...

MedlinePlus:34 Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. glucose comes from the foods you eat. insulin is a hormone that helps the glucose get into your cells to give them energy. with type 1 diabetes, your body does not make insulin. with type 2 diabetes, the more common type, your body does not make or use insulin well. without enough insulin, the glucose stays in your blood. you can also have prediabetes. this means that your blood sugar is higher than normal but not high enough to be called diabetes. having prediabetes puts you at a higher risk of getting type 2 diabetes. over time, having too much glucose in your blood can cause serious problems. it can damage your eyes, kidneys, and nerves. diabetes can also cause heart disease, stroke and even the need to remove a limb. pregnant women can also get diabetes, called gestational diabetes. a blood test can show if you have diabetes. exercise, weight control and sticking to your meal plan can help control your diabetes. you should also monitor your glucose level and take medicine if prescribed. nih: national institute of diabetes and digestive and kidney diseases

Wikipedia:65 Diabetes mellitus type more...

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent

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Diabetes Mellitus, Insulin-Dependent, Aliases & Descriptions:

Name: Diabetes Mellitus, Insulin-Dependent 47 23 32
Diabetes Mellitus 32 10 12 45
Insulin-Dependent Diabetes Mellitus 10 43 23
Type 1 Diabetes Mellitus 32 10 23
Type 1 Diabetes 43 23 24
Diabetes 47 34 4
Iddm 10 43 23
Diabetes Mellitus, Type 1 47 23
Diabetes Mellitus Type 1 43 23
Juvenile-Onset Diabetes 43 23
Diabetes Mellitus, Insulin-Dependent, Susceptibility to 11
Diabetes Mellitus, Insulin Dependent 43
 
Diabetes Mellitus Insulin-Dependent 45
Juvenile-Onset Diabetes Mellitus 23
Diabetes Mellitus, Type I 47
Type I Diabetes Mellitus 10
Diabetes Autoimmune 45
Autoimmune Diabetes 23
Juvenile Diabetes 23
Diabetes, Type 1 47
Diabetes Type 1 34
T1d 23
Jod 23


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases


Related Diseases for Diabetes Mellitus, Insulin-Dependent

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Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 7
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 22 Diabetes Mellitus, Insulin-Dependent, 23
Diabetes Mellitus, Insulin-Dependent, 18 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 21 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 8 Diabetes Mellitus, Insulin-Dependent, 24
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 2
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 20
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 6

Diseases related to Diabetes Mellitus, Insulin-Dependent via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1555)
idRelated DiseaseScoreTop Affiliating Genes
1maturity-onset diabetes of the young31.4HNF1A, PAX4, INS
2hyperglycemia31.4IGFBP3, INS, PAX4, HNF1A
3coronary artery disease31.3IL6, CCR5, INS
4glucose intolerance31.0IGFBP3, INS, HNF1A
5diabetes mellitus, noninsulin-dependent30.8HNF1A, IL6, PAX4, INS, IGFBP3
6hyperinsulinism30.8PAX4, INS, IGFBP3
7insulinoma30.7INS, PAX4, HNF1A
8hypothyroidism30.7IGFBP3, INS, CTLA4
9hepatitis c30.6OAS1, CCR5, IFIH1, HNF1A
10arthritis30.6PTPN22, FOXP3, CCR5, IL6, CTLA4
11polycystic ovary syndrome30.6INS, IGFBP3
12graves' disease30.6PTPN22, CCR5, IL2RA, CTLA4
13hypopituitarism30.6INS, IGFBP3
14rheumatoid arthritis30.5PTPN22, FOXP3, CCR5, IL2RA, IL6, CTLA4
15diabetic ketoacidosis30.5CTLA4, INS
16galactosemia30.4IGFBP3, HGF, HNF1A
17asthma30.4FOXP3, CCR5, IL2RA, CTLA4
18breast cancer30.4IGFBP3, INS, PTPN3, CCR5, HGF, HNF1A
19lymphopenia30.4PTPN22, FOXP3, IL2RA, IL6
20obesity30.4HNF1A, IL6, INS, IGFBP3
21prostate cancer30.4IGFBP3, CCR5, IL6, HGF, CTLA4
22rabson-mendenhall syndrome30.4IGFBP3, INS
23growth hormone deficiency30.4INS, IGFBP3
24hyperthyroidism30.3CTLA4, PTPN22, INS
25psoriasis30.3PTPN22, IL2RA, IL6, CTLA4
26hepatitis b30.2CTLA4, IL2RA, CCR5
27hepatocellular carcinoma30.2INS, PTPN3, FOXP3, IL6, HGF, HNF1A
28adenoma30.2CTLA4, HNF1A, PTPN3, INS, IGFBP3
29uveitis30.2CCR5, IL2RA, CTLA4
30lung cancer30.1IGFBP3, PTPN3, FOXP3, HGF, HNF1A, CTLA4
31anovulation30.1IGFBP3, INS
32influenza30.1CCR5, IFIH1, HNF1A
33thyroiditis30.1CTLA4, PTPN22
34systemic lupus erythematosus30.0OAS1, PTPN22, CCR5, IL2RA, IL6, CTLA4
35chronic kidney failure30.0IGFBP3, INS, CCR5, IL6, HGF
36laron dwarfism30.0IGFBP3
37colitis30.0CTLA4, IL6, FOXP3
38inflammatory bowel disease30.0PTPN22, FOXP3, CCR5, IL6, CTLA4
39juvenile rheumatoid arthritis29.9IGFBP3, IL2RA, IL6
40kidney cancer29.9IL2RA, HGF, HNF1A, CTLA4
41melanoma29.9PTPN3, FOXP3, CCR5, IFIH1, HGF, CTLA4
42wegener granulomatosis29.8CCR5, CTLA4
43connective tissue disease29.8PTPN22, FOXP3, IL2RA, IL6, CTLA4
44systemic scleroderma29.7PTPN22, IL2RA, CTLA4
45ulcerative colitis29.7CTLA4, IL6, IL2RA, IGFBP3
46vogt-koyanagi-harada disease29.6IL2RA
47behcet's disease29.5CTLA4, IL2RA, CCR5
48hashimoto thyroiditis29.5CTLA4, IL2RA, PTPN22
49primary hyperoxaluria29.5INS, IL6, HGF, HNF1A, CTLA4
50diabetes insipidus11.2

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent:



Diseases related to diabetes mellitus, insulin-dependent

Symptoms for Diabetes Mellitus, Insulin-Dependent

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Symptoms by clinical synopsis from OMIM:

222100

Clinical features from OMIM:

222100

HPO human phenotypes related to Diabetes Mellitus, Insulin-Dependent:

(show all 8)
id Description Frequency HPO Source Accession
1 polyuria HP:0000103
2 diabetes mellitus HP:0000819
3 heterogeneous HP:0001425
4 polydipsia HP:0001959
5 ketoacidosis HP:0001993
6 polyphagia HP:0002591
7 abnormality of the immune system HP:0002715
8 hyperglycemia HP:0003074

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent

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Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus, Insulin-Dependent

Search NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent

Inferred drug relations via UMLS62/NDF-RT41:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Diabetes Mellitus, Insulin-Dependent:
Bone marrow-derived adult mesenchymal stem cells for treatment of type I diabetes
Dendritic cells for type I diabetes
DIABECELL
Endothelial progenitor cell and islet cotransplantation for diabetes
Hematopoietic stem cell transplantation for new-onset type 1 diabetes
Hematopoietic stem cells for early-onset type I diabetes mellitus
Hematopoietic stem cells for treatment of early-onset type I diabetes mellitus
Hematopoietic stem cells for type I diabetes mellitus
Human islet transplantation to treat diabetes
Porcine embryonic pancreatic tissue transplantation for diabetes
Prochymal
Regulatory T cells for type I diabetes
StemGenex
Umbilical cord-derived mesenchymal stem cells for treatment of type I diabetes
VC-01, embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Embryonic/Adult Cultured Cells Related to Diabetes Mellitus, Insulin-Dependent:
Bone marrow-derived mesenchymal stem cells (family)
Mouse immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Encapsulated neonatal porcine islets (DIABECELL, PMIDs: 15808678, 18814261, 17607741, 21358330, 21535153, 16131605, 23088180, 19063691, 16298643, 11202575, 17381690
Mouse Islets, PMID: 22362173
Umbilical cord blood-derived endothelial progenitor cells, PMID: 22362173
Pancreatic islets, PMID: 22362173
Peripheral blood-derived hematopoietic stem cells (family), PMID: 23190701
Peripheral blood-derived hematopoietic stem cells, PMID: 23190701
Peripheral blood-derived hematopoietic stem cells , PMID: 23190701
Bone marrow-derived hematopoietic stem cells (family)
Pancreatic islets (cadavers), PMIDs: 15983207, 10911004
Fetal pancreatic tissue, PMIDs: 16768546, 19433788
Regulatory T cells, PMIDs: 15322272, 16903917
Adipose-derived stem cells (StemGenex
Umbilical cord-derived mesenchymal stem cells (family)
Pancreatic endoderm/endocrine precursor-like cells, PMIDs: 18834446, 22623968, 18034635

Genetic Tests for Diabetes Mellitus, Insulin-Dependent

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Genetic tests related to Diabetes Mellitus, Insulin-Dependent:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 124

Anatomical Context for Diabetes Mellitus, Insulin-Dependent

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MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent:

33
Pancreas, Eye, Kidney, Bone, Heart, Testes, Bone marrow, T cells, Endothelial, Pancreatic islet

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetes Mellitus, Insulin-Dependent:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Diabetes Mellitus, Insulin-Dependent or affiliated genes

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Publications for Diabetes Mellitus, Insulin-Dependent

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Articles related to Diabetes Mellitus, Insulin-Dependent:

idTitleAuthorsYear
1
Autoantibodies to tissue transglutaminase in patients from eastern India with malnutrition-modulated diabetes mellitus, insulin-dependent diabetes mellitus, and non-insulin-dependent diabetes mellitus. (12021113)
2002
2
Characterization of insulin-like growth factor-binding proteins produced by cultured fibroblasts from patients with noninsulin-dependent diabetes mellitus, insulin-dependent diabetes mellitus, or obesity. (7527414)
1994

Variations for Diabetes Mellitus, Insulin-Dependent

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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Insulin-Dependent:

64
id Symbol AA change Variation ID SNP ID
1PTPN22p.Arg620TrpVAR_022605rs2476601

Clinvar genetic disease variations for Diabetes Mellitus, Insulin-Dependent:

7
id Gene Variation Type Significance SNP ID Assembly Location
1HNF1ANM_000545.5(HNF1A): c.608G> A (p.Arg203His)single nucleotide variantLikely pathogenicGRCh37Chr 12, 121431404: 121431404
2HNF1ANM_000545.5(HNF1A): c.872dupC (p.Gly292Argfs)duplicationPathogenicGRCh37Chr 12, 121432125: 121432125

Expression for genes affiliated with Diabetes Mellitus, Insulin-Dependent

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LifeMap Discovery
Genes differentially expressed in tissues of Diabetes Mellitus, Insulin-Dependent patients vs. healthy controls: 32 (show all 10)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CDC6cell division cycle 6Blood+3.600.000
2SLC2A5solute carrier family 2 (facilitated glucose/fructose transporter), member 5Blood+3.600.000
3DUSP5dual specificity phosphatase 5Blood+3.600.000
4GGHgamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)Blood+3.570.000
5CCNA2cyclin A2Blood+3.560.000
6IGLV2-23immunoglobulin lambda variable 2-23Blood+3.550.000
7MELKmaternal embryonic leucine zipper kinaseBlood+3.540.000
8GINS2GINS complex subunit 2 (Psf2 homolog)Blood+3.530.000
9CHEK1checkpoint kinase 1Blood+3.510.000
10UHRF1ubiquitin-like with PHD and ring finger domains 1Blood+3.500.000


Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent.

Pathways for genes affiliated with Diabetes Mellitus, Insulin-Dependent

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Pathways related to Diabetes Mellitus, Insulin-Dependent according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9FOXP3, IL2RA
29.8INS, HNF1A, IL6
3
Show member pathways
9.7IL6, CCR5, FOXP3
4
Show member pathways
9.7IL6, HGF, IL2RA
5
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.6IL6, CCR5, CTLA4
6
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.6IL2RA, INS, IL6
7
Show member pathways
9.6HNF1A, INS, PAX4
8
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.5CTLA4, IL2RA, FOXP3
99.5IGFBP3, INS, IL6
10
Show member pathways
9.5ITPR3, CTLA4, IL2RA
11
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.4PTPN3, IL6, CCR5
12
Show member pathways
9.4HGF, IL6, IL2RA, OAS1
13
Show member pathways
9.4IL2RA, IL6, ITPR3, HGF
14
Show member pathways
9.4HGF, IL2RA, ITPR3, IL6
159.4INS, HGF, IL6, IL2RA
169.3IL2RA, IFIH1, FOXP3, PTPN22
17
Show member pathways
9.3IFIH1, OAS1, IL2RA, IL6
18
Show member pathways
9.3INS, IL2RA, IL6, CTLA4
19
Show member pathways
9.1HGF, INS, IL2RA, IL6, ITPR3
20
Show member pathways
9.1IL2RA, INS, ITPR3, HGF, IL6
21
Show member pathways
9.1IL6, HGF, IL2RA, CCR5, INS
22
Show member pathways
8.9PTPN3, HGF, IL6, ITPR3, IL2RA
23
Show member pathways
8.6IL6, PTPN22, PTPN3, CCR5, IL2RA, HGF

Compounds for genes affiliated with Diabetes Mellitus, Insulin-Dependent

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Compounds related to Diabetes Mellitus, Insulin-Dependent according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1pha 6657526110.3IL6, HGF
2su 112746110.3HGF, IL6
3pf 04217903 mesylate6110.3IL6, HGF
4rebamipide4510.2HGF, IL6
5abatacept45 1311.2CTLA4, IL6
6mecasermin45 1311.0INS, IGFBP3
72,5-oligoadenylate4510.0IL6, OAS1, IL2RA
8ivig459.9IL2RA, IL6, CCR5
9atazanavir45 51 1311.9CCR5, INS
10infliximab45 51 1311.9IL2RA, IL6, CTLA4
11oxandrolone45 1310.9IGFBP3, INS
12megestrol acetate459.8IL6, IL2RA, IGFBP3
13rituximab45 51 1311.8IL6, IL2RA, CTLA4
14thalidomide45 51 61 1312.7CTLA4, IL2RA, HGF, IL6
15dextran sulfate459.7CCR5, HGF, IL6, IGFBP3
16indomethacin45 30 61 1312.7HNF1A, HGF, IL2RA, IL6
17il 10459.7CTLA4, IL6, CCR5, IL2RA
18aprotinin45 1310.6IGFBP3, IL6, HGF
19prednisolone45 30 1311.6IGFBP3, IL2RA, HGF, IL6
20rantes459.5IL6, IL2RA, CCR5, CTLA4
21herbimycin a45 6110.5PTPN3, HGF, IL6, IL2RA
22tgf beta1459.5IGFBP3, FOXP3, IL6, HGF, CTLA4
23epinephrine45 26 1311.4IL6, IL2RA, INS, IGFBP3
24c-peptide459.4INS, PTPN3, HNF1A, IGFBP3
25ly294002459.3CTLA4, HGF, IL6, IGFBP3, INS
26rapamycin459.3CCR5, INS, IL2RA, CTLA4, FOXP3
27norepinephrine45 26 1311.3IGFBP3, IL2RA, IL6, HGF, INS
28vitamin-e459.3CCR5, IL2RA, HGF
29methotrexate51 45 1311.3IGFBP3, IL2RA, CTLA4, HGF, IL6
30polysaccharide459.3IL2RA, IGFBP3, CCR5, HGF
31histamine45 30 2611.3IL6, CCR5, IL2RA, HGF
32tacrolimus45 51 1311.2PTPN3, INS, IL2RA, HGF, CTLA4
33creatinine459.1INS, IGFBP3, HGF, HNF1A, IL2RA, IL6
34testosterone45 61 26 1312.1IL6, IGFBP3, INS, HGF, IL2RA
35retinoic acid45 2610.1IGFBP3, HNF1A, IL6, IFIH1, CCR5, HGF
36thymidine45 2610.1CTLA4, HNF1A, HGF, IL2RA, IGFBP3, IL6
37vitamin d459.0IL2RA, HGF, CCR5, IL6, IGFBP3, CTLA4
38paclitaxel45 51 1311.0HGF, IL2RA, PTPN3, IGFBP3
39arginine459.0INS, IL2RA, HGF, IGFBP3, CCR5, PTPN22
40cyclosporin a45 30 6110.8HGF, CTLA4, IL6, IGFBP3, IL2RA, CCR5
41aspartate458.7IL2RA, IGFBP3, ITPR3, CCR5, HGF, PTPN3
42heparin45 30 26 1311.7HGF, CCR5, ITPR3, PTPN3, IGFBP3, IL2RA
43pge2458.6HGF, CCR5, FOXP3, IL2RA, PTPN3, IGFBP3
44cholesterol45 30 26 1311.6PTPN3, INS, IGFBP3, HNF1A, IL6, CCR5
45alanine458.6CTLA4, IL6, CCR5, HGF, PTPN3, INS
46glucose458.4PAX4, CTLA4, IGFBP3, HNF1A, PTPN3, INS
47tyrosine458.2INS, PTPN22, PTPN3, IL2RA, IL6, HGF
48glutamate458.2HGF, CTLA4, IL2RA, CCR5, PTPN22, INS
49dexamethasone45 51 30 1311.0CTLA4, HNF1A, HGF, IL2RA, IL6, PTPN3
50estrogen458.0IGFBP3, CTLA4, IL6, IL2RA, PTPN3, CCR5

GO Terms for genes affiliated with Diabetes Mellitus, Insulin-Dependent

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Cellular components related to Diabetes Mellitus, Insulin-Dependent according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2CTLA4, IL6, IL2RA, CCR5

Biological processes related to Diabetes Mellitus, Insulin-Dependent according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretionGO:005071010.1IL6, FOXP3
2negative regulation of gluconeogenesisGO:004572110.1INS, IL6
3positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.9INS, IL6, HGF
4glucose homeostasisGO:00425939.9HNF1A, OAS1, INS
5endocrine pancreas developmentGO:00310189.8PAX4, INS, IL6
6negative regulation of immune responseGO:00507779.8FOXP3, IL2RA, CTLA4
7platelet activationGO:00301689.8IL6, ITPR3, HGF
8negative regulation of T cell proliferationGO:00421309.8IL2RA, CTLA4, FOXP3
9positive regulation of MAPK cascadeGO:00434109.7IL6, INS, IGFBP3
10positive regulation of cell differentiationGO:00455979.7PAX4, INS
11positive regulation of nitric oxide biosynthetic processGO:00454299.7IL6, INS
12response to virusGO:00096159.7IFIH1, FOXP3, OAS1

Molecular functions related to Diabetes Mellitus, Insulin-Dependent according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.6CTLA4, INS, OAS1, PTPN22, PTPN3, FOXP3

Products for genes affiliated with Diabetes Mellitus, Insulin-Dependent

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Sources for Diabetes Mellitus, Insulin-Dependent

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet