Diabetes Mellitus, Insulin-Dependent malady
Categories: Genetic diseases (common), Endocrine diseases, Metabolic diseases
50OMIM, 24Genetics Home Reference, 68UniProtKB/Swiss-Prot, 33LifeMap Discovery®, 66UMLS, 36MedlinePlus, 2CDC, 37MeSH, 11Disease Ontology, 13DISEASES, 25GTR, 48Novoseek, 46NIH Rare Diseases, 12diseasecard, 28ICD10, 30ICD9CM, 43NCIt, 35MedGen, 60SNOMED-CT, 62The Human Phenotype Ontology
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Aliases & Descriptions for Diabetes Mellitus, Insulin-Dependent:
diabetes mellitus, insulin-dependent:
Global: Genetic diseases (common), Metabolic diseases
Anatomical: Endocrine diseases
MedlinePlus:36 Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. glucose comes from the foods you eat. insulin is a hormone that helps the glucose get into your cells to give them energy. with type 1 diabetes, your body does not make insulin. with type 2 diabetes, the more common type, your body does not make or use insulin well. without enough insulin, the glucose stays in your blood. you can also have prediabetes. this means that your blood sugar is higher than normal but not high enough to be called diabetes. having prediabetes puts you at a higher risk of getting type 2 diabetes. over time, having too much glucose in your blood can cause serious problems. it can damage your eyes, kidneys, and nerves. diabetes can also cause heart disease, stroke and even the need to remove a limb. pregnant women can also get diabetes, called gestational diabetes. blood tests can show if you have diabetes. one type of test, the a1c, can also check on how you are managing your diabetes. exercise, weight control and sticking to your meal plan can help control your diabetes. you should also monitor your blood glucose level and take medicine if prescribed. nih: national institute of diabetes and digestive and kidney diseases
MalaCards based summary: Diabetes Mellitus, Insulin-Dependent, also known as diabetes mellitus, is related to diabetes mellitus, noninsulin-dependent and obesity, and has symptoms including tremor, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus, Insulin-Dependent is HNF1A (HNF1 Homeobox A), and among its related pathways are NF-kappaB Signaling and p70S6K Signaling. The drugs chromium picolinate and insulin have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and endothelial, and related mouse phenotypes are liver/biliary system and immune system.
Disease Ontology:11 A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.
NIH Rare Diseases:46 Diabetes mellitus type 1 (dm1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. dm1 can occur at any age, but usually develops by early adulthood, most often in adolescence. symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. the exact cause of dm1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. a predisposition to develop dm1 runs in families, but no known inheritance pattern exists. treatment includes blood sugar control and insulin replacement therapy. improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. if not treated, the condition can be life-threatening. over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body. last updated: 4/25/2014
UniProtKB/Swiss-Prot:68 Diabetes mellitus, insulin-dependent: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Genetics Home Reference:24 Type 1 diabetes is a disorder characterized by abnormally high blood sugar levels. In this form of diabetes, specialized cells in the pancreas called beta cells stop producing insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the inability to use glucose for energy or to control the amount of sugar in the blood.
OMIM:50 The type of diabetes mellitus called IDDM is a disorder of glucose homeostasis that is characterized by susceptibility... (222100) more...
Wikipedia:69 Diabetes mellitus type 1 (also known as type 1 diabetes) is a form of diabetes mellitus in which not... more...
HPO human phenotypes related to Diabetes Mellitus, Insulin-Dependent:(show all 7)
UMLS symptoms related to Diabetes Mellitus, Insulin-Dependent:tremor, equilibration disorder, o/e - right eye background diabetic retinopathy, o/e - left eye background diabetic retinopathy, o/e - right eye preproliferative diabetic retinopathy, o/e - left eye preproliferative diabetic retinopathy, o/e - right eye proliferative diabetic retinopathy, o/e - left eye proliferative diabetic retinopathy, o/e - right eye diabetic maculopathy, o/e - left eye diabetic maculopathy, symptoms, polyuria, polydipsia
Drugs for Diabetes Mellitus, Insulin-Dependent (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 475)
Interventional clinical trials:(show top 50) (show all 6797)
Search NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent
Inferred drug relations via UMLS66/NDF-RT44:Show with subtypes
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Diabetes Mellitus, Insulin-Dependent cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Diabetes Mellitus, Insulin-Dependent:
Embryonic/Adult Cultured Cells Related to Diabetes Mellitus, Insulin-Dependent:
MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent:34
Kidney, Heart, Endothelial, Pancreas, Testes, Bone, Eye
Data from LifeMap, the Embryonic Development and Stem Cells Database
Cells/anatomical compartments in embryo or adult related to Diabetes Mellitus, Insulin-Dependent:
MGI Mouse Phenotypes related to Diabetes Mellitus, Insulin-Dependent:39 (show all 16)
Articles related to Diabetes Mellitus, Insulin-Dependent:
UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Insulin-Dependent:68
Clinvar genetic disease variations for Diabetes Mellitus, Insulin-Dependent:5
Copy number variations for Diabetes Mellitus, Insulin-Dependent from CNVD:6 (show all 28)
Genes differentially expressed in tissues of Diabetes Mellitus, Insulin-Dependent patients vs. healthy controls: 33
Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent.
Pathways related to Diabetes Mellitus, Insulin-Dependent according to KEGG:32
Pathways related to Diabetes Mellitus, Insulin-Dependent according to GeneCards Suite gene sharing:(show all 15)
Cellular components related to Diabetes Mellitus, Insulin-Dependent according to GeneCards Suite gene sharing:
Biological processes related to Diabetes Mellitus, Insulin-Dependent according to GeneCards Suite gene sharing:(show all 22)
Molecular functions related to Diabetes Mellitus, Insulin-Dependent according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet