IDDM
MCID: DBT085
MIFTS: 80

Diabetes Mellitus, Insulin-Dependent (IDDM) malady

Categories: Genetic diseases, Rare diseases, Endocrine diseases, Metabolic diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent

Aliases & Descriptions for Diabetes Mellitus, Insulin-Dependent:

Name: Diabetes Mellitus, Insulin-Dependent 54 25 66 38 69
Diabetes Mellitus 38 12 29 52 42 14 69
Diabetes 54 41 3 14 69
Type 1 Diabetes Mellitus 38 12 25 14
Iddm 12 50 25 66
Insulin-Dependent Diabetes Mellitus 12 50 25
Diabetes Mellitus, Type 1 54 25 42
Type 1 Diabetes 50 25 29
Diabetes Mellitus Type 1 50 25
Juvenile-Onset Diabetes 50 25
Diabetes Mellitus, Insulin-Dependent, Susceptibility to 13
Diabetes Mellitus, Insulin Dependent 50
Diabetes Mellitus Insulin-Dependent 52
Juvenile-Onset Diabetes Mellitus 25
Diabetes Mellitus, Type I 54
Type I Diabetes Mellitus 12
Diabetes, Autoimmune 69
Autoimmune Diabetes 25
Diabetes Autoimmune 52
Juvenile Diabetes 25
Diabetes, Type 1 54
Diabetes Type 1 41
Type I Diabetes 14
Jod 25
T1d 25

Characteristics:

HPO:

32
diabetes mellitus, insulin-dependent:
Inheritance heterogeneous


Classifications:



Summaries for Diabetes Mellitus, Insulin-Dependent

MedlinePlus : 41 diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. glucose comes from the foods you eat. insulin is a hormone that helps the glucose get into your cells to give them energy. with type 1 diabetes, your body does not make insulin. with type 2 diabetes, the more common type, your body does not make or use insulin well. without enough insulin, the glucose stays in your blood. you can also have prediabetes. this means that your blood sugar is higher than normal but not high enough to be called diabetes. having prediabetes puts you at a higher risk of getting type 2 diabetes. over time, having too much glucose in your blood can cause serious problems. it can damage your eyes, kidneys, and nerves. diabetes can also cause heart disease, stroke and even the need to remove a limb. pregnant women can also get diabetes, called gestational diabetes. blood tests can show if you have diabetes. one type of test, the a1c, can also check on how you are managing your diabetes. exercise, weight control and sticking to your meal plan can help control your diabetes. you should also monitor your blood glucose level and take medicine if prescribed. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, also known as diabetes mellitus, is related to diabetes mellitus, insulin-dependent, 20 and diabetes mellitus, insulin-dependent, 2, and has symptoms including polyuria, polydipsia and diabetes mellitus. An important gene associated with Diabetes Mellitus, Insulin-Dependent is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are Type I diabetes mellitus and Insulin secretion. The drugs Metformin and Linagliptin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Pancreas, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Disease Ontology : 12 A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.

Genetics Home Reference : 25 Type 1 diabetes is a disorder characterized by abnormally high blood sugar levels. In this form of diabetes, specialized cells in the pancreas called beta cells stop producing insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the inability to use glucose for energy or to control the amount of sugar in the blood.

NIH Rare Diseases : 50 diabetes mellitus type 1 (dm1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. dm1 can occur at any age, but usually develops by early adulthood, most often in adolescence. symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. the exact cause of dm1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. a predisposition to develop dm1 runs in families, but no known inheritance pattern exists. treatment includes blood sugar control and insulin replacement therapy. improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. if not treated, the condition can be life-threatening. over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body. last updated: 4/25/2014

OMIM : 54 The type of diabetes mellitus called IDDM is a disorder of glucose homeostasis that is characterized by susceptibility... (222100) more...

UniProtKB/Swiss-Prot : 66 Diabetes mellitus, insulin-dependent: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Related Diseases for Diabetes Mellitus, Insulin-Dependent

Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 7
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 22 Diabetes Mellitus, Insulin-Dependent, 23
Diabetes Mellitus, Insulin-Dependent, 18 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 21 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 8 Diabetes Mellitus, Insulin-Dependent, 24
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 2
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 20
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 6

Diseases related to Diabetes Mellitus, Insulin-Dependent via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
id Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent, 20 34.9 ACE AKR1B1 ALB CTLA4 FOXP3 GAD1
2 diabetes mellitus, insulin-dependent, 2 12.6
3 diabetes mellitus, insulin-dependent, 22 12.6
4 diabetes mellitus, insulin-dependent, 19 12.6
5 diabetes mellitus, insulin-dependent, 12 12.6
6 diabetes, mellitus, insulin-dependent 10 12.6
7 diabetes mellitus, insulin-dependent, 13 12.5
8 diabetes mellitus, insulin-dependent, 23 12.5
9 diabetes mellitus, insulin-dependent, 21 12.5
10 diabetes mellitus, insulin-dependent, 5 12.5
11 diabetes mellitus, insulin-dependent, 8 12.5
12 diabetes mellitus, insulin-dependent, 7 12.5
13 diabetes mellitus, insulin-dependent, 24 12.5
14 diabetes mellitus, insulin-dependent, 17 12.4
15 diabetes mellitus, insulin-dependent, 4 12.4
16 diabetes mellitus, insulin-dependent, 18 12.4
17 diabetes mellitus, insulin-dependent, 11 12.4
18 diabetes mellitus, insulin-dependent, 15 12.4
19 diabetes mellitus, insulin-dependent, 3 12.4
20 diabetes mellitus, insulin-dependent, 6 12.4
21 diabetes insipidus, nephrogenic 12.3
22 diabetes insipidus, neurohypophyseal 12.3
23 diabetes mellitus, insulin-dependent, x-linked 12.3
24 renal cysts and diabetes syndrome 12.3
25 diabetes mellitus, noninsulin-dependent 12.3
26 diabetes mellitus, permanent neonatal 12.2
27 maturity-onset diabetes of the young 12.2
28 gestational diabetes 12.2
29 diabetes mellitus, transient neonatal, 1 12.2
30 diabetes insipidus 12.2
31 neonatal diabetes mellitus 12.2
32 histiocytosis-lymphadenopathy plus syndrome 12.0
33 type 1 diabetes mellitus 10 11.6
34 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 11.6
35 autonomic neuropathy 11.2
36 diabetes mellitus, ketosis-prone 11.2
37 wolcott-rallison syndrome 11.1
38 autoimmune polyendocrine syndrome, type ii 11.0
39 mody, type i 10.9
40 monogenic diabetes 10.7
41 articulation disorder 10.6 CTLA4 FOXP3 GAD2 IL6 INS PTPN22
42 denys-drash syndrome 10.6 CTLA4 FOXP3 GAD1 GAD2 INS PTPN22
43 maturity-onset diabetes of the young 6 10.6 ACE AKR1B1 ALB GAD1 GAD2 GCK
44 brain stem glioma 10.6 AKR1B1 ALB GCK HNF1A IAPP IGF1
45 breast cancer 10.5 CTLA4 GAD2 INS PTPRN
46 body dysmorphic disorder 10.5 ACE ALB GAD2 GCK IAPP IGF1
47 mosaic trisomy 13 10.5 GCK HNF1A IAPP INS
48 peroneal neuropathy 10.5 ACE AKR1B1 ALB GAD2 GCK IAPP
49 neutral lipid storage disease with myopathy 10.5 CTLA4 INS PTPN22
50 pleuropulmonary blastoma 10.5 CTLA4 HNF1A INS

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent:



Diseases related to Diabetes Mellitus, Insulin-Dependent

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent

Symptoms by clinical synopsis from OMIM:

222100

Clinical features from OMIM:

222100

Human phenotypes related to Diabetes Mellitus, Insulin-Dependent:

32 (show all 7)
id Description HPO Frequency HPO Source Accession
1 polyuria 32 HP:0000103
2 polydipsia 32 HP:0001959
3 diabetes mellitus 32 HP:0000819
4 abnormality of the immune system 32 HP:0002715
5 polyphagia 32 HP:0002591
6 hyperglycemia 32 HP:0003074
7 ketoacidosis 32 HP:0001993

UMLS symptoms related to Diabetes Mellitus, Insulin-Dependent:


angina pectoris, tremor, equilibration disorder, symptoms, polyuria, polydipsia

MGI Mouse Phenotypes related to Diabetes Mellitus, Insulin-Dependent:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.47 IL6 INS ITPR3 PTPN22 PTPRN WFS1
2 endocrine/exocrine gland MP:0005379 10.45 ALB CTLA4 FOXP3 GAD1 GAD2 GCK
3 growth/size/body region MP:0005378 10.41 ACE AKR1B1 FOXP3 GAD1 GAD2 GCK
4 behavior/neurological MP:0005386 10.33 FOXP3 GAD1 GAD2 HLA-DQB1 HNF1A IGFBP3
5 mortality/aging MP:0010768 10.33 ACE AKR1B1 ALB CTLA4 FOXP3 GAD1
6 digestive/alimentary MP:0005381 10.31 ALB CTLA4 FOXP3 GAD1 GAD2 HLA-DQB1
7 immune system MP:0005387 10.22 ACE CTLA4 FOXP3 GAD2 HLA-DQB1 IAPP
8 liver/biliary system MP:0005370 10.17 ACE ALB CTLA4 FOXP3 GCK HLA-DQB1
9 integument MP:0010771 10.11 CTLA4 FOXP3 HNF1A IGF1 IGFBP3 IL6
10 muscle MP:0005369 10.02 ALB GAD2 HLA-DQB1 HNF1A IGF1 IGFBP3
11 renal/urinary system MP:0005367 10 ACE AKR1B1 ALB FOXP3 GCK HLA-DQB1
12 normal MP:0002873 9.97 ALB CTLA4 FOXP3 GAD1 GAD2 HLA-DQB1
13 reproductive system MP:0005389 9.81 ACE FOXP3 GAD2 HLA-DQB1 HNF1A IGF1
14 respiratory system MP:0005388 9.56 CTLA4 FOXP3 GAD1 GAD2 HLA-DQB1 IGF1
15 skeleton MP:0005390 9.32 AKR1B1 CTLA4 GAD1 HNF1A IAPP IGF1

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent

Drugs for Diabetes Mellitus, Insulin-Dependent (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 908)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
2
Linagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 668270-12-0 10096344
3
Voglibose Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83480-29-9 444020
4
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
6
Citalopram Approved Phase 4 59729-33-8 2771
7
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2 137862-53-4 60846
8
Repaglinide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 135062-02-1 65981
9
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 64-17-5 702
10
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 160337-95-1
11
Saxagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 361442-04-8 11243969
12
Everolimus Approved Phase 4,Phase 3,Phase 1,Phase 2 159351-69-6 6442177
13
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22916-47-8 4189
14
Paclitaxel Approved, Vet_approved Phase 4 33069-62-4 36314
15
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 53123-88-9 5284616 6436030 46835353
16
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
17
Febuxostat Approved Phase 4 144060-53-7 134018
18
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
19
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
20
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2 75847-73-3 5362032 40466924
21
Enalaprilat Approved Phase 4,Phase 3,Phase 2 76420-72-9 6917719
22
Pancrelipase Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53608-75-6
23
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 133107-64-9
24
Ezetimibe Approved Phase 4,Phase 3,Phase 2 163222-33-1 150311
25
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 79902-63-9 54454
26
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 111025-46-8 4829
27
Glipizide Approved Phase 4,Phase 3,Phase 2,Phase 1 29094-61-9 3478
28
Liraglutide Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 204656-20-2
29
Orlistat Approved, Investigational Phase 4,Phase 2 96829-58-2 3034010
30
rituximab Approved Phase 4,Phase 1,Phase 2 174722-31-7 10201696
31
Glimepiride Approved Phase 4,Phase 3,Phase 2,Phase 1 93479-97-1 3476
32
Ticagrelor Approved Phase 4,Phase 3 274693-27-5 9871419
33
Ticlopidine Approved Phase 4,Phase 2 55142-85-3 5472
34
Gliclazide Approved Phase 4,Phase 3,Phase 2,Phase 1 21187-98-4 3475
35
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1 116094-23-6 16132418
36
Insulin-glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1 207748-29-6
37
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 141758-74-9 15991534
38
Acarbose Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 56180-94-0 441184
39
Alogliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 850649-61-5 11450633
40
Sertraline Approved Phase 4 79617-96-2 68617
41
Vildagliptin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 274901-16-5 6918537
42
Atenolol Approved Phase 4 29122-68-7 2249
43
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
44
Diazoxide Approved Phase 4 364-98-7 3019
45
Glyburide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 10238-21-8 3488
46
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
47
Candesartan Approved Phase 4,Phase 3,Phase 2 139481-59-7 2541
48
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103-90-2 1983
49
Adalimumab Approved Phase 4 331731-18-1 16219006
50
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 637568 5271565

Interventional clinical trials:

(show top 50) (show all 6911)
id Name Status NCT ID Phase
1 A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care Unknown status NCT00939250 Phase 4
2 Diabetes Prevention Program in Schizophrenia [DPPS] Unknown status NCT00182494 Phase 4
3 Prevention of Diabetes Mellitus Development in Women Who Had Already Experienced A Gestational Diabetes Unknown status NCT00265746 Phase 4
4 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02097342 Phase 4
5 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
6 Organization Program of DiabEtes INsulIN ManaGement Unknown status NCT01338376 Phase 4
7 Prospective Randomized Trials of Gastric Bypass Surgery in Patients With Type II Diabetes Mellitus Unknown status NCT00540462 Phase 4
8 Type 2 Diabetes Mellitus and Atherosclerosis Unknown status NCT01250340 Phase 4
9 Efficacy Study of Escitalopram for Depression in Patients With Diabetes Unknown status NCT00650897 Phase 4
10 Effects of Valsartan and Aliskiren on Hemostatic Indices in Hypertensive Diabetics Unknown status NCT01095822 Phase 4
11 A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients Unknown status NCT00336310 Phase 4
12 Prevalence of Macrovascular Disease in Type 2 Diabetes Mellitus Unknown status NCT00298844 Phase 4
13 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4
14 German Diabetes-Diet-Intervention and Energy Restriction-Trial (DDIET) Unknown status NCT01409330 Phase 4
15 Investigation of a Switch From Insulin Therapy to a Metformin & Saxagliptin Combination in Patients With Type 2 Diabetes Mellitus Unknown status NCT01206647 Phase 4
16 Continuous Glucose Monitoring in Patients With Type 2 Diabetes Unknown status NCT00529815 Phase 4
17 Comparison of Diabetes Mellitus and Non-diabetes Mellitus Patients for DES Surface COVERage by OCT Unknown status NCT01021930 Phase 4
18 Assessment of Surface Coverage of Two Types of DES in Diabetes Mellitus and Non- Diabetes Mellitus Unknown status NCT01023919 Phase 4
19 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4
20 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4
21 The Effect of Uric Acid Lowering in Type 1 Diabetes Unknown status NCT02344602 Phase 4
22 Aspirin and Enalapril in Microalbuminuric Type 2 Diabetes Mellitus Patients Unknown status NCT00427271 Phase 4
23 Mixed Meal Test in Type 1 Diabetes on Insulin Pump Therapy: Optimization of Artificial Pancreas Unknown status NCT02003274 Phase 4
24 Using Sitagliptin as a Treatment to Prevent New Onset Diabetes After Kidney Transplantation Unknown status NCT00936663 Phase 4
25 A Study on Ca Blocker Versus AII Antagonists in Hypertension With Type 2 Diabetes Unknown status NCT00144144 Phase 4
26 Bone Turnover in Type 2 Diabetes Patients Unknown status NCT00732121 Phase 4
27 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4
28 Study to Compare the Effect of Vytorin (Simvastatin/Ezetimibe) 10/20mg Versus Atorvastatin 20mg on ApoB/ApoA1 Ratio in Subjects With Diabetes Unknown status NCT01185236 Phase 4
29 The Efficacy of Glucerna SR in Chinese Drug-naïve Subjects With Type 2 Diabetes Unknown status NCT02248714 Phase 4
30 How Does the Diabetes Drug, Pioglitazone, Reduce Protein Loss in the Urine? Unknown status NCT00749047 Phase 4
31 Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia Unknown status NCT01267448 Phase 4
32 A Crossover Study With Hexalacton in Patients With Type 1 Diabetes and Microalbuminuria Unknown status NCT00843388 Phase 4
33 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
34 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4
35 Vascular Effects of Sitagliptin in Diabetes Mellitus Unknown status NCT01096277 Phase 4
36 Combinatorial Therapy for Peristent Type 2 Diabetes After Gastric Banding Unknown status NCT01597531 Phase 4
37 Multifactorial Intervention in Type 2 Diabetes - Italy Unknown status NCT01240070 Phase 4
38 Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes Unknown status NCT01280682 Phase 4
39 Effect of Linagliptin in Comparison With Glimepiride as Add on to Metformin on Postprandial Beta Cell Function, Postprandial Metabolism and Oxidative Stress in Patients With Type 2 Diabetes Mellitus Unknown status NCT01547104 Phase 4
40 Mechanistic Study of the Systolic Blood Pressure Lowering Effect of Dapagliflozin in Type 2 Diabetes Unknown status NCT02372955 Phase 4
41 Multiple Grain in Type 2 Diabetes Unknown status NCT00337337 Phase 4
42 Effect of Modifying Anti-platelet Treatment to Ticagrelor in Patients With Diabetes and Low Response to Clopidogrel Unknown status NCT01643031 Phase 4
43 Study of Combination Therapy of Gliclazide MR and Basal Insulin Versus Insulin Monotherapy to Treat Type 2 Diabetes Unknown status NCT00736515 Phase 4
44 Variation in Sulphonylurea Response in Type 2 Diabetes Unknown status NCT00738088 Phase 4
45 Comparison of the Efficacy and Safety Between Pioglitazone and Placebo Added to Combination Therapy in Type 2 Diabetes Unknown status NCT00991055 Phase 4
46 Insulin Effects on Metabolism and Cardiovascular Function in Type 2 Diabetes Unknown status NCT00747409 Phase 4
47 52 Week Trial of Liraglutide in Type 1 Diabetes Unknown status NCT01787916 Phase 4
48 CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) Unknown status NCT01848990 Phase 4
49 Study of Comparison the Treatment Effect Between Gastric Bypass and Exenatide in Type 2 Diabetes Unknown status NCT01435980 Phase 4
50 the Effect of Vitamin D on the Serum Thioredoxin, TBP-2, Thioredoxin Reductase, Gene Expression of TBP-2 in Patients With Type II Diabetes Unknown status NCT01876563 Phase 4

Search NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Diabetes Mellitus, Insulin-Dependent cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Diabetes Mellitus, Insulin-Dependent:
Bone marrow-derived adult mesenchymal stem cells for treatment of type I diabetes
Bone marrow-derived mononuclear cells for the treatment of diabetes mellitus
Dendritic cells for type I diabetes
Dental pulp stem cell-derived islet clusters for treating diabetes
DIABECELL
Encapsulated embryonic stem cell-derived NKX6.1-positive cells for diabetes
Encapsulated embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Endothelial progenitor cell and islet cotransplantation for diabetes
Fibroblast-derived pancreatic progenitor cells for treatment of diabetes
Hematopoietic stem cell transplantation for new-onset type 1 diabetes
Hematopoietic stem cells for early-onset type I diabetes mellitus
Hematopoietic stem cells for treatment of early-onset type I diabetes mellitus
Hematopoietic stem cells for type I diabetes mellitus
Human islet transplantation to treat diabetes
Porcine embryonic pancreatic tissue transplantation for diabetes
Prochymal
Regulatory T cells for type I diabetes
Stem cell-derived pancreatic islets for diabetes treatment
StemGenex
Umbilical cord-derived mesenchymal stem cells for treatment of type I diabetes
VC-01, embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Embryonic/Adult Cultured Cells Related to Diabetes Mellitus, Insulin-Dependent:
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mononuclear cells (family)
Immunosuppressive dendritic cells PMIDs: 17665986 18552749 23148758
Mouse immunosuppressive dendritic cells PMIDs: 17665986 18552749 23148758
Islet-like cell clusters PMIDs: 23845187
Encapsulated neonatal porcine islets (DIABECELL PMIDs: 15808678 18814261 17607741 21358330 21535153 16131605 23088180 19063691 16298643 11202575 17381690
Pancreatic endoderm and endocrine precursors in cell suspension
Pancreatic endoderm/endocrine precursor-like cells PMIDs: 24788136 20587750 18834446 22623968 18034635
Mouse Islets PMIDs: 22362173
Umbilical cord blood-derived endothelial progenitor cells PMIDs: 22362173
Pancreatic islets PMIDs: 22362173
Pancreatic progenitor-like cells PMIDs: 24506886
Peripheral blood-derived hematopoietic stem cells (family) PMIDs: 23190701
Peripheral blood-derived hematopoietic stem cells PMIDs: 23190701
Peripheral blood-derived hematopoietic stem cells PMIDs: 23190701
Bone marrow-derived hematopoietic stem cells (family)
Pancreatic islets (cadavers) PMIDs: 15983207 10911004
Fetal pancreatic tissue PMIDs: 16768546 19433788
Regulatory T cells PMIDs: 15322272 16903917
Islet-like structures PMIDs: 24268157
Adipose-derived stem cells (StemGenex
Wharton-Jelly-derived mesenchymal stem cells

Cochrane evidence based reviews: diabetes mellitus, type 1

Genetic Tests for Diabetes Mellitus, Insulin-Dependent

Genetic tests related to Diabetes Mellitus, Insulin-Dependent:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 1 29
2 Diabetes Mellitus 29

Anatomical Context for Diabetes Mellitus, Insulin-Dependent

MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent:

39
Eye, Kidney, Pancreas, Bone, Testes, Heart, Pancreatic Islet
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Diabetes Mellitus, Insulin-Dependent:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Pancreas Islets of Langerhans Mature Beta Cells Potential therapeutic candidate, affected by disease
3 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate
4 Blood Cord Blood Mesenchymal Stem Cells Potential therapeutic candidate
5 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
6 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Diabetes Mellitus, Insulin-Dependent

Articles related to Diabetes Mellitus, Insulin-Dependent:

id Title Authors Year
1
Autoantibodies to tissue transglutaminase in patients from eastern India with malnutrition-modulated diabetes mellitus, insulin-dependent diabetes mellitus, and non-insulin-dependent diabetes mellitus. ( 12021113 )
2002
2
Characterization of insulin-like growth factor-binding proteins produced by cultured fibroblasts from patients with noninsulin-dependent diabetes mellitus, insulin-dependent diabetes mellitus, or obesity. ( 7527414 )
1994