MCID: DBT085
MIFTS: 83

Diabetes Mellitus, Insulin-Dependent malady

Genetic diseases, Rare diseases, Endocrine diseases categories

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent

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Diabetes Mellitus, Insulin-Dependent, Aliases & Descriptions:

Name: Diabetes Mellitus, Insulin-Dependent 45 21 30 60
Diabetes Mellitus 30 9 11 43 60
Diabetes 45 32 3 60
Insulin-Dependent Diabetes Mellitus 9 41 21
Type 1 Diabetes Mellitus 30 9 21
Type 1 Diabetes 41 21 22
Iddm 9 41 21
Diabetes Mellitus, Type 1 45 21
Diabetes Mellitus Type 1 41 21
Juvenile-Onset Diabetes 41 21
Diabetes Mellitus, Insulin-Dependent, Susceptibility to 10
Diabetes Mellitus, Insulin Dependent 41
 
Diabetes Mellitus Insulin-Dependent 43
Juvenile-Onset Diabetes Mellitus 21
Diabetes Mellitus, Type I 45
Type I Diabetes Mellitus 9
Diabetes, Autoimmune 60
Autoimmune Diabetes 21
Diabetes Autoimmune 43
Juvenile Diabetes 21
Diabetes, Type 1 45
Diabetes Type 1 32
Jod 21
T1d 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Endocrine diseases


Summaries for Diabetes Mellitus, Insulin-Dependent

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NIH Rare Diseases:41 Diabetes mellitus type 1 (dm1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. dm1 can occur at any age, but usually develops by early adulthood, most often in adolescence. symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. the exact cause of dm1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. a predisposition to develop dm1 runs in families, but no known inheritance pattern exists. treatment includes blood sugar control and insulin replacement therapy. improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. if not treated, the condition can be life-threatening. over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body. last updated: 4/25/2014

MalaCards based summary: Diabetes Mellitus, Insulin-Dependent, also known as diabetes mellitus, is related to maturity-onset diabetes of the young and hyperglycemia, and has symptoms including polyuria, diabetes mellitus and heterogeneous. An important gene associated with Diabetes Mellitus, Insulin-Dependent is HNF1A (HNF1 homeobox A), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Adipogenesis. The drugs chromium picolinate and insulin and the compounds pha 665752 and su 11274 have been mentioned in the context of this disorder. Affiliated tissues include pancreas, eye and kidney, and related mouse phenotypes are renal/urinary system and integument.

Disease Ontology:9 A diabetes mellitus that results from the body's failure to produce insulin and has material basis in autoimmune destruction of insulin-producing beta cells of the pancreas.

Genetics Home Reference:21 Type 1 diabetes is a disorder characterized by abnormally high blood sugar levels. In this form of diabetes, specialized cells in the pancreas called beta cells stop producing insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the inability to use glucose for energy or to control the amount of sugar in the blood.

OMIM:45 The type of diabetes mellitus called IDDM is a disorder of glucose homeostasis that is characterized by susceptibility... (222100) more...

MedlinePlus:32 Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. glucose comes from the foods you eat. insulin is a hormone that helps the glucose get into your cells to give them energy. with type 1 diabetes, your body does not make insulin. with type 2 diabetes, the more common type, your body does not make or use insulin well. without enough insulin, the glucose stays in your blood. you can also have prediabetes. this means that your blood sugar is higher than normal but not high enough to be called diabetes. having prediabetes puts you at a higher risk of getting type 2 diabetes. over time, having too much glucose in your blood can cause serious problems. it can damage your eyes, kidneys, and nerves. diabetes can also cause heart disease, stroke and even the need to remove a limb. pregnant women can also get diabetes, called gestational diabetes. a blood test can show if you have diabetes. exercise, weight control and sticking to your meal plan can help control your diabetes. you should also monitor your glucose level and take medicine if prescribed. nih: national institute of diabetes and digestive and kidney diseases

Wikipedia:63 Diabetes mellitus type more...

Related Diseases for Diabetes Mellitus, Insulin-Dependent

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Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 7
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 22 Diabetes Mellitus, Insulin-Dependent, 23
Diabetes Mellitus, Insulin-Dependent, 18 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 21 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 8 Diabetes Mellitus, Insulin-Dependent, 24
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 2
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 20
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 6

Diseases related to Diabetes Mellitus, Insulin-Dependent via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1555)
idRelated DiseaseScoreTop Affiliating Genes
1maturity-onset diabetes of the young31.9HNF1A, PAX4, INS
2hyperglycemia31.6IGFBP3, INS, PAX4, HNF1A
3glucose intolerance31.4IGFBP3, INS, HNF1A
4coronary artery disease31.3IL6, CCR5, INS
5insulinoma31.1INS, PAX4, HNF1A
6diabetic ketoacidosis31.1CTLA4, INS
7hyperinsulinism31.0PAX4, INS, IGFBP3
8hypothyroidism31.0IGFBP3, INS, CTLA4
9hypopituitarism30.9INS, IGFBP3
10rabson-mendenhall syndrome30.8IGFBP3, INS
11polycystic ovary syndrome30.8INS, IGFBP3
12diabetes mellitus, noninsulin-dependent30.8HNF1A, IL6, PAX4, INS, IGFBP3
13galactosemia30.7IGFBP3, HGF, HNF1A
14growth hormone deficiency30.7INS, IGFBP3
15graves' disease30.6PTPN22, CCR5, IL2RA, CTLA4
16hepatitis b30.6CTLA4, IL2RA, CCR5
17laron dwarfism30.6IGFBP3
18hepatitis c30.6OAS1, CCR5, IFIH1, HNF1A
19uveitis30.6CCR5, IL2RA, CTLA4
20anovulation30.5IGFBP3, INS
21hyperthyroidism30.5CTLA4, PTPN22, INS
22obesity30.5HNF1A, IL6, INS, IGFBP3
23thyroiditis30.4CTLA4, PTPN22
24asthma30.4FOXP3, CCR5, IL2RA, CTLA4
25influenza30.3CCR5, IFIH1, HNF1A
26wegener granulomatosis30.3CCR5, CTLA4
27arthritis30.3PTPN22, FOXP3, CCR5, IL6, CTLA4
28lymphopenia30.2PTPN22, FOXP3, IL2RA, IL6
29psoriasis30.2PTPN22, IL2RA, IL6, CTLA4
30adenoma30.2CTLA4, HNF1A, PTPN3, INS, IGFBP3
31vogt-koyanagi-harada disease30.2IL2RA
32juvenile rheumatoid arthritis30.2IGFBP3, IL2RA, IL6
33prostate cancer30.1IGFBP3, CCR5, IL6, HGF, CTLA4
34colitis30.1CTLA4, IL6, FOXP3
35breast cancer30.0IGFBP3, INS, PTPN3, CCR5, HGF, HNF1A
36kidney cancer30.0IL2RA, HGF, HNF1A, CTLA4
37rheumatoid arthritis30.0PTPN22, FOXP3, CCR5, IL2RA, IL6, CTLA4
38chronic kidney failure29.9IGFBP3, INS, CCR5, IL6, HGF
39behcet's disease29.9CTLA4, IL2RA, CCR5
40systemic scleroderma29.8PTPN22, IL2RA, CTLA4
41lung cancer29.7IGFBP3, PTPN3, FOXP3, HGF, HNF1A, CTLA4
42ulcerative colitis29.7CTLA4, IL6, IL2RA, IGFBP3
43hepatocellular carcinoma29.7INS, PTPN3, FOXP3, IL6, HGF, HNF1A
44hashimoto thyroiditis29.6CTLA4, IL2RA, PTPN22
45inflammatory bowel disease29.6PTPN22, FOXP3, CCR5, IL6, CTLA4
46melanoma29.5PTPN3, FOXP3, CCR5, IFIH1, HGF, CTLA4
47connective tissue disease29.4PTPN22, FOXP3, IL2RA, IL6, CTLA4
48primary hyperoxaluria29.4INS, IL6, HGF, HNF1A, CTLA4
49systemic lupus erythematosus29.4OAS1, PTPN22, CCR5, IL2RA, IL6, CTLA4
50ipex syndrome29.2PTPN3, FOXP3, CCR5, IL2RA, IL6

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent:



Diseases related to diabetes mellitus, insulin-dependent

Symptoms for Diabetes Mellitus, Insulin-Dependent

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Symptoms by clinical synopsis from OMIM:

222100

Clinical features from OMIM:

222100

HPO human phenotypes related to Diabetes Mellitus, Insulin-Dependent:

(show all 8)
id Description Frequency HPO Source Accession
1 polyuria HP:0000103
2 diabetes mellitus HP:0000819
3 heterogeneous HP:0001425
4 polydipsia HP:0001959
5 ketoacidosis HP:0001993
6 polyphagia HP:0002591
7 abnormality of the immune system HP:0002715
8 hyperglycemia HP:0003074

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent

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Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus, Insulin-Dependent

Search NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent

Inferred drug relations via UMLS60/NDF-RT39:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Diabetes Mellitus, Insulin-Dependent:
Bone marrow-derived adult mesenchymal stem cells for treatment of type I diabetes
Dendritic cells for type I diabetes
DIABECELL
Endothelial progenitor cell and islet cotransplantation for diabetes
Hematopoietic stem cell transplantation for new-onset type 1 diabetes
Hematopoietic stem cells for early-onset type I diabetes mellitus
Hematopoietic stem cells for treatment of early-onset type I diabetes mellitus
Hematopoietic stem cells for type I diabetes mellitus
Human islet transplantation to treat diabetes
Porcine embryonic pancreatic tissue transplantation for diabetes
Prochymal
Regulatory T cells for type I diabetes
StemGenex
Umbilical cord-derived mesenchymal stem cells for treatment of type I diabetes
VC-01, embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Embryonic/Adult Cultured Cells Related to Diabetes Mellitus, Insulin-Dependent:
Bone marrow-derived mesenchymal stem cells (family)
Mouse immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Immunosuppressive dendritic cells, PMIDs: 17665986, 18552749, 23148758
Encapsulated neonatal porcine islets (DIABECELL, PMIDs: 15808678, 18814261, 17607741, 21358330, 21535153, 16131605, 23088180, 19063691, 16298643, 11202575, 17381690
Mouse Islets, PMID: 22362173
Umbilical cord blood-derived endothelial progenitor cells, PMID: 22362173
Pancreatic islets, PMID: 22362173
Peripheral blood-derived hematopoietic stem cells (family), PMID: 23190701
Peripheral blood-derived hematopoietic stem cells, PMID: 23190701
Peripheral blood-derived hematopoietic stem cells , PMID: 23190701
Bone marrow-derived hematopoietic stem cells (family)
Pancreatic islets (cadavers), PMIDs: 15983207, 10911004
Fetal pancreatic tissue, PMIDs: 16768546, 19433788
Regulatory T cells, PMIDs: 15322272, 16903917
Adipose-derived stem cells (StemGenex
Umbilical cord-derived mesenchymal stem cells (family)
Pancreatic endoderm/endocrine precursor-like cells, PMIDs: 18834446, 22623968, 18034635

Genetic Tests for Diabetes Mellitus, Insulin-Dependent

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Genetic tests related to Diabetes Mellitus, Insulin-Dependent:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 122

Anatomical Context for Diabetes Mellitus, Insulin-Dependent

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MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent:

31
Pancreas, Eye, Kidney, Bone, Heart, Testes, Bone marrow, T cells, Endothelial, Pancreatic islet

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Diabetes Mellitus, Insulin-Dependent:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate
2 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
5 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
6 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Diabetes Mellitus, Insulin-Dependent or affiliated genes

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Publications for Diabetes Mellitus, Insulin-Dependent

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Articles related to Diabetes Mellitus, Insulin-Dependent:

idTitleAuthorsYear
1
Autoantibodies to tissue transglutaminase in patients from eastern India with malnutrition-modulated diabetes mellitus, insulin-dependent diabetes mellitus, and non-insulin-dependent diabetes mellitus. (12021113)
2002
2
Characterization of insulin-like growth factor-binding proteins produced by cultured fibroblasts from patients with noninsulin-dependent diabetes mellitus, insulin-dependent diabetes mellitus, or obesity. (7527414)
1994

Variations for Diabetes Mellitus, Insulin-Dependent

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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Insulin-Dependent:

62
id Symbol AA change Variation ID SNP ID
1PTPN22p.Arg620TrpVAR_022605rs2476601

Clinvar genetic disease variations for Diabetes Mellitus, Insulin-Dependent:

6
id Gene Variation Type Significance SNP ID Assembly Location
1HNF1ANM_000545.5(HNF1A): c.608G> A (p.Arg203His)single nucleotide variantLikely pathogenicGRCh37Chr 12, 121431404: 121431404
2HNF1ANM_000545.5(HNF1A): c.872dupC (p.Gly292Argfs)duplicationPathogenicGRCh37Chr 12, 121432125: 121432125

Expression for genes affiliated with Diabetes Mellitus, Insulin-Dependent

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LifeMap Discovery
Genes differentially expressed in tissues of Diabetes Mellitus, Insulin-Dependent patients vs. healthy controls: 30 (show all 10)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1CDC6cell division cycle 6Blood+3.600.000
2SLC2A5solute carrier family 2 (facilitated glucose/fructose transporter), member 5Blood+3.600.000
3DUSP5dual specificity phosphatase 5Blood+3.600.000
4GGHgamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)Blood+3.570.000
5CCNA2cyclin A2Blood+3.560.000
6IGLV2-23immunoglobulin lambda variable 2-23Blood+3.550.000
7MELKmaternal embryonic leucine zipper kinaseBlood+3.540.000
8GINS2GINS complex subunit 2 (Psf2 homolog)Blood+3.530.000
9CHEK1checkpoint kinase 1Blood+3.510.000
10UHRF1ubiquitin-like with PHD and ring finger domains 1Blood+3.500.000

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent.

Pathways for genes affiliated with Diabetes Mellitus, Insulin-Dependent

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Pathways related to Diabetes Mellitus, Insulin-Dependent according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9FOXP3, IL2RA
29.8HNF1A, IL6, INS
3
Show member pathways
9.7IL6, CCR5, FOXP3
4
Show member pathways
9.7HGF, IL6, IL2RA
5
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.6CTLA4, IL6, CCR5
6
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.6IL6, IL2RA, INS
7
Show member pathways
9.6HNF1A, PAX4, INS
8
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.5FOXP3, IL2RA, CTLA4
99.5IGFBP3, INS, IL6
10
Show member pathways
9.5ITPR3, IL2RA, CTLA4
11
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.4PTPN3, CCR5, IL6
12
Show member pathways
9.4HGF, IL6, IL2RA, OAS1
13
Show member pathways
9.4ITPR3, IL2RA, IL6, HGF
14
Show member pathways
9.4ITPR3, IL2RA, IL6, HGF
159.4HGF, IL6, IL2RA, INS
169.3PTPN22, FOXP3, IFIH1, IL2RA
17
Show member pathways
9.3OAS1, IFIH1, IL2RA, IL6
18
Show member pathways
9.3CTLA4, IL6, IL2RA, INS
19
Show member pathways
9.1INS, ITPR3, IL2RA, IL6, HGF
20
Show member pathways
9.1INS, ITPR3, IL2RA, IL6, HGF
21
Show member pathways
9.1INS, CCR5, IL2RA, IL6, HGF
22
Show member pathways
8.9PTPN3, ITPR3, IL2RA, IL6, HGF
23
Show member pathways
8.6HGF, IL6, IL2RA, CCR5, PTPN3, PTPN22

Compounds for genes affiliated with Diabetes Mellitus, Insulin-Dependent

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Compounds related to Diabetes Mellitus, Insulin-Dependent according to GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1pha 6657525910.3IL6, HGF
2su 112745910.3HGF, IL6
3pf 04217903 mesylate5910.3IL6, HGF
4rebamipide4310.2HGF, IL6
5abatacept43 1211.2CTLA4, IL6
6mecasermin43 1211.0INS, IGFBP3
72,5-oligoadenylate4310.0IL6, OAS1, IL2RA
8ivig439.9IL2RA, IL6, CCR5
9atazanavir43 49 1211.9CCR5, INS
10infliximab43 49 1211.9IL2RA, IL6, CTLA4
11oxandrolone43 1210.9IGFBP3, INS
12megestrol acetate439.8IL6, IL2RA, IGFBP3
13rituximab43 49 1211.8IL6, IL2RA, CTLA4
14thalidomide43 49 59 1212.7CTLA4, IL2RA, HGF, IL6
15dextran sulfate439.7CCR5, HGF, IL6, IGFBP3
16indomethacin43 28 59 1212.7HNF1A, HGF, IL2RA, IL6
17il 10439.7CTLA4, IL6, CCR5, IL2RA
18aprotinin43 1210.6IGFBP3, IL6, HGF
19prednisolone43 28 1211.6IGFBP3, IL2RA, HGF, IL6
20rantes439.5IL6, IL2RA, CCR5, CTLA4
21herbimycin a43 5910.5PTPN3, HGF, IL6, IL2RA
22tgf beta1439.5IGFBP3, FOXP3, IL6, HGF, CTLA4
23epinephrine43 24 1211.4IL6, IL2RA, INS, IGFBP3
24c-peptide439.4INS, PTPN3, HNF1A, IGFBP3
25ly294002439.3CTLA4, HGF, IL6, IGFBP3, INS
26rapamycin439.3CCR5, INS, IL2RA, CTLA4, FOXP3
27norepinephrine43 24 1211.3IGFBP3, IL2RA, IL6, HGF, INS
28vitamin-e439.3CCR5, IL2RA, HGF
29methotrexate49 43 1211.3IGFBP3, IL2RA, CTLA4, HGF, IL6
30polysaccharide439.3IL2RA, IGFBP3, CCR5, HGF
31histamine43 28 2411.3IL6, CCR5, IL2RA, HGF
32tacrolimus43 49 1211.2PTPN3, INS, IL2RA, HGF, CTLA4
33creatinine439.1INS, IGFBP3, HGF, HNF1A, IL2RA, IL6
34testosterone43 59 24 1212.1IL6, IGFBP3, INS, HGF, IL2RA
35retinoic acid43 2410.1IGFBP3, HNF1A, IL6, IFIH1, CCR5, HGF
36thymidine43 2410.1CTLA4, HNF1A, HGF, IL2RA, IGFBP3, IL6
37vitamin d439.0IL2RA, HGF, CCR5, IL6, IGFBP3, CTLA4
38paclitaxel43 49 1211.0HGF, IL2RA, PTPN3, IGFBP3
39arginine439.0INS, IL2RA, HGF, IGFBP3, CCR5, PTPN22
40cyclosporin a43 28 5910.8HGF, CTLA4, IL6, IGFBP3, IL2RA, CCR5
41aspartate438.7IL2RA, IGFBP3, ITPR3, CCR5, HGF, PTPN3
42heparin43 28 24 1211.7HGF, CCR5, ITPR3, PTPN3, IGFBP3, IL2RA
43pge2438.6HGF, CCR5, FOXP3, IL2RA, PTPN3, IGFBP3
44cholesterol43 28 24 1211.6PTPN3, INS, IGFBP3, HNF1A, IL6, CCR5
45alanine438.6CTLA4, IL6, CCR5, HGF, PTPN3, INS
46glucose438.4PAX4, CTLA4, IGFBP3, HNF1A, PTPN3, INS
47tyrosine438.2INS, PTPN22, PTPN3, IL2RA, IL6, HGF
48glutamate438.2HGF, CTLA4, IL2RA, CCR5, PTPN22, INS
49dexamethasone43 49 28 1211.0CTLA4, HNF1A, HGF, IL2RA, IL6, PTPN3
50estrogen438.0IGFBP3, CTLA4, IL6, IL2RA, PTPN3, CCR5

GO Terms for genes affiliated with Diabetes Mellitus, Insulin-Dependent

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Cellular components related to Diabetes Mellitus, Insulin-Dependent according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2CTLA4, IL6, IL2RA, CCR5

Biological processes related to Diabetes Mellitus, Insulin-Dependent according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretionGO:005071010.1IL6, FOXP3
2negative regulation of gluconeogenesisGO:004572110.1IL6, INS
3positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.9HGF, IL6, INS
4glucose homeostasisGO:00425939.9INS, OAS1, HNF1A
5endocrine pancreas developmentGO:00310189.8INS, PAX4, IL6
6negative regulation of immune responseGO:00507779.8CTLA4, IL2RA, FOXP3
7platelet activationGO:00301689.8HGF, IL6, ITPR3
8negative regulation of T cell proliferationGO:00421309.8CTLA4, IL2RA, FOXP3
9positive regulation of MAPK cascadeGO:00434109.7IL6, INS, IGFBP3
10positive regulation of cell differentiationGO:00455979.7PAX4, INS
11positive regulation of nitric oxide biosynthetic processGO:00454299.7IL6, INS
12response to virusGO:00096159.7OAS1, FOXP3, IFIH1

Molecular functions related to Diabetes Mellitus, Insulin-Dependent according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.6CTLA4, INS, OAS1, PTPN22, PTPN3, FOXP3

Products for genes affiliated with Diabetes Mellitus, Insulin-Dependent

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Sources for Diabetes Mellitus, Insulin-Dependent

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet