MCID: DBT085
MIFTS: 79

Diabetes Mellitus, Insulin-Dependent

Categories: Genetic diseases, Rare diseases, Endocrine diseases, Metabolic diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent:

Name: Diabetes Mellitus, Insulin-Dependent 54 25 71 38 69
Diabetes Mellitus 38 12 29 52 42 14 69
Type 1 Diabetes Mellitus 38 12 25 14
Diabetes 54 41 3 69
Iddm 12 50 25 71
Insulin-Dependent Diabetes Mellitus 12 50 25
Diabetes Mellitus, Type 1 54 25 42
Diabetes Mellitus Type 1 50 25 29
Juvenile-Onset Diabetes 50 25
Type 1 Diabetes 50 25
Diabetes Mellitus, Insulin-Dependent, Susceptibility to 13
Diabetes Mellitus, Insulin Dependent 50
Diabetes Mellitus Insulin-Dependent 52
Juvenile-Onset Diabetes Mellitus 25
Diabetes Mellitus, Type I 54
Type I Diabetes Mellitus 12
Diabetes, Autoimmune 69
Autoimmune Diabetes 25
Diabetes Autoimmune 52
Juvenile Diabetes 25
Diabetes, Type 1 54
Diabetes Type 1 41
Jod 25
T1d 25

Characteristics:

OMIM:

54
Inheritance:
heterogeneous
autosomal recessive susceptibility


HPO:

32
diabetes mellitus, insulin-dependent:
Inheritance heterogeneous


Classifications:



Summaries for Diabetes Mellitus, Insulin-Dependent

MedlinePlus : 41 diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. glucose comes from the foods you eat. insulin is a hormone that helps the glucose get into your cells to give them energy. with type 1 diabetes, your body does not make insulin. with type 2 diabetes, the more common type, your body does not make or use insulin well. without enough insulin, the glucose stays in your blood. you can also have prediabetes. this means that your blood sugar is higher than normal but not high enough to be called diabetes. having prediabetes puts you at a higher risk of getting type 2 diabetes. over time, having too much glucose in your blood can cause serious problems. it can damage your eyes, kidneys, and nerves. diabetes can also cause heart disease, stroke and even the need to remove a limb. pregnant women can also get diabetes, called gestational diabetes. blood tests can show if you have diabetes. one type of test, the a1c, can also check on how you are managing your diabetes. exercise, weight control and sticking to your meal plan can help control your diabetes. you should also monitor your blood glucose level and take medicine if prescribed. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, also known as diabetes mellitus, is related to diabetes mellitus, insulin-dependent, 20 and diabetes mellitus, insulin-dependent, 2, and has symptoms including hyperglycemia, polyuria and diabetes mellitus. An important gene associated with Diabetes Mellitus, Insulin-Dependent is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are Type I diabetes mellitus and NF-kappaB Signaling. The drugs Insulin Detemir and Insulin Glargine have been mentioned in the context of this disorder. Affiliated tissues include Bone and Pancreas, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Disease Ontology : 12 A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.

Genetics Home Reference : 25 Type 1 diabetes is a disorder characterized by abnormally high blood sugar levels. In this form of diabetes, specialized cells in the pancreas called beta cells stop producing insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the inability to use glucose for energy or to control the amount of sugar in the blood.

NIH Rare Diseases : 50 diabetes mellitus type 1 (dm1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. dm1 can occur at any age, but usually develops by early adulthood, most often in adolescence. symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. the exact cause of dm1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. a predisposition to develop dm1 runs in families, but no known inheritance pattern exists. treatment includes blood sugar control and insulin replacement therapy. improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. if not treated, the condition can be life-threatening. over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body. last updated: 4/25/2014

OMIM : 54
The type of diabetes mellitus called IDDM is a disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. It is a genetically heterogeneous autoimmune disease affecting about 0.3% of Caucasian populations (Todd, 1990). Genetic studies of IDDM have focused on the identification of loci associated with increased susceptibility to this multifactorial phenotype. The classical phenotype of diabetes mellitus is polydipsia, polyphagia, and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. (222100)

UniProtKB/Swiss-Prot : 71 Diabetes mellitus, insulin-dependent: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Related Diseases for Diabetes Mellitus, Insulin-Dependent

Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 7
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 22 Diabetes Mellitus, Insulin-Dependent, 23
Diabetes Mellitus, Insulin-Dependent, 18 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 21 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 8 Diabetes Mellitus, Insulin-Dependent, 24
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 2
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 20
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 6

Diseases related to Diabetes Mellitus, Insulin-Dependent via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
id Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent, 20 12.7
2 diabetes mellitus, insulin-dependent, 2 12.6
3 diabetes mellitus, insulin-dependent, 22 12.6
4 diabetes mellitus, insulin-dependent, 19 12.6
5 diabetes mellitus, insulin-dependent, 12 12.6
6 diabetes, mellitus, insulin-dependent 10 12.5
7 diabetes mellitus, insulin-dependent, 5 12.5
8 diabetes mellitus, insulin-dependent, 13 12.5
9 diabetes mellitus, insulin-dependent, 21 12.4
10 diabetes mellitus, insulin-dependent, 8 12.4
11 diabetes mellitus, insulin-dependent, 7 12.4
12 diabetes mellitus, insulin-dependent, 24 12.4
13 diabetes mellitus, insulin-dependent, 23 12.4
14 diabetes mellitus, insulin-dependent, 11 12.4
15 diabetes mellitus, insulin-dependent, 15 12.4
16 diabetes mellitus, insulin-dependent, 3 12.4
17 diabetes mellitus, insulin-dependent, 6 12.4
18 diabetes mellitus, insulin-dependent, 17 12.4
19 diabetes mellitus, insulin-dependent, 4 12.4
20 diabetes mellitus, insulin-dependent, 18 12.4
21 diabetes insipidus, nephrogenic 12.3
22 diabetes insipidus, neurohypophyseal 12.3
23 diabetes mellitus, insulin-dependent, x-linked 12.3
24 renal cysts and diabetes syndrome 12.3
25 diabetes mellitus, noninsulin-dependent 12.2
26 diabetes mellitus, permanent neonatal 12.2
27 maturity-onset diabetes of the young 12.2
28 gestational diabetes 12.2
29 diabetes insipidus 12.2
30 diabetes mellitus, transient neonatal, 1 12.2
31 neonatal diabetes mellitus 12.2
32 diabetes and deafness, maternally inherited 12.1
33 histiocytosis-lymphadenopathy plus syndrome 12.0
34 hepatic adenoma, somatic 11.8 ACE ALB CTLA4 FOXP3 GAD1 GAD2
35 maturity-onset diabetes of the young 6 11.6 ACE ALB GAD1 GAD2 GCK HNF1A
36 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 11.6
37 survival motor neuron spinal muscular atrophy 11.6 ACE ALB GAD2 GCK IAPP IGF1
38 hypertrichosis 11.6 ACE ALB GAD2 GCK IAPP IGF1
39 pseudohypoparathyroidism 11.5 CTLA4 FOXP3 GAD2 IL6 INS PTPN22
40 combined cellular and humoral immune defects with granulomas 11.5 CTLA4 FOXP3 GAD1 GAD2 INS PTPN22
41 peroneal neuropathy 11.5 ALB GCK HNF1A IAPP IGF1 INS
42 morning glory syndrome 11.5 GCK HNF1A IAPP INS KCNJ11
43 antidepressant type abuse 11.5 GCK HNF1A INS KCNJ11 PTPRN
44 lymphoma 11.5 ACE ALB CTLA4 FOXP3 IL6
45 lacrimal system cancer 11.5 ACE ALB CTLA4 FOXP3 IL6
46 exostosis 11.5 GCK IGF1 IGFBP3 INS KCNJ11
47 intraocular lymphoma 11.5 GCK IAPP INS MEN1 PTPRN
48 breast cancer 11.5 CTLA4 GAD2 INS PTPRN
49 congenital stationary night blindness 11.5 GCK HNF1A IAPP INS KCNJ11
50 biliary cirrhosis, primary, 4 11.4 CTLA4 GAD1 GAD2 INS

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent:



Diseases related to Diabetes Mellitus, Insulin-Dependent

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent

Symptoms via clinical synopsis from OMIM:

54

Lab:
hyperglycemia
relative insulin deficiency

Endocrine:
diabetes mellitus

Metabolic:
ketoacidosis
abnormally increased gluconeogenesis
insufficient glucose disposal

GU:
polyuria
hyperglycemia-induced osmotic diuresis

GI:
polydipsia
polyphagia

Immunology:
pancreatic autoimmunity


Clinical features from OMIM:

222100

Human phenotypes related to Diabetes Mellitus, Insulin-Dependent:

32 (show all 7)
id Description HPO Frequency HPO Source Accession
1 hyperglycemia 32 HP:0003074
2 polyuria 32 HP:0000103
3 diabetes mellitus 32 HP:0000819
4 polydipsia 32 HP:0001959
5 ketoacidosis 32 HP:0001993
6 polyphagia 32 HP:0002591
7 abnormality of the immune system 32 HP:0002715

UMLS symptoms related to Diabetes Mellitus, Insulin-Dependent:


angina pectoris, tremor, equilibration disorder, symptoms, polyuria, polydipsia

MGI Mouse Phenotypes related to Diabetes Mellitus, Insulin-Dependent:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.47 PTPN22 PTPRN ACE ALB CTLA4 FOXP3
2 endocrine/exocrine gland MP:0005379 10.45 GCK HNF1A IGF1 IGFBP3 IL6 INS
3 growth/size/body region MP:0005378 10.41 PTPN22 ACE FOXP3 GAD1 GAD2 GCK
4 mortality/aging MP:0010768 10.33 ACE ALB CTLA4 FOXP3 GAD1 GAD2
5 digestive/alimentary MP:0005381 10.28 ALB CTLA4 FOXP3 GAD1 GAD2 HNF1A
6 immune system MP:0005387 10.26 MEN1 PTPN22 PTPRN ACE CTLA4 FOXP3
7 liver/biliary system MP:0005370 10.21 ACE ALB CTLA4 FOXP3 GCK HNF1A
8 cardiovascular system MP:0005385 10.2 IGF1 IL6 INS KCNJ11 MEN1 PTPN22
9 integument MP:0010771 10.16 CTLA4 FOXP3 HNF1A IFIH1 IGF1 IGFBP3
10 adipose tissue MP:0005375 10.1 ACE HNF1A IGF1 IGFBP3 IL6 INS
11 muscle MP:0005369 10.07 ALB GAD2 HNF1A IGF1 IGFBP3 IL6
12 renal/urinary system MP:0005367 9.96 ACE ALB FOXP3 GCK HNF1A IFIH1
13 no phenotypic analysis MP:0003012 9.87 FOXP3 GAD1 GAD2 HNF1A INS ITPR3
14 reproductive system MP:0005389 9.81 GAD2 HNF1A IGF1 IL6 INS ITPR3
15 respiratory system MP:0005388 9.5 CTLA4 FOXP3 GAD1 GAD2 IGF1 IL6
16 skeleton MP:0005390 9.28 CTLA4 GAD1 HNF1A IAPP IGF1 IL6

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent

Drugs for Diabetes Mellitus, Insulin-Dependent (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 572)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
2
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1 160337-95-1
3
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
4
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 204656-20-2 44147092
5
Pancrelipase Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 53608-75-6
6
rituximab Approved Phase 4,Phase 3,Phase 1,Phase 2 174722-31-7 10201696
7
Febuxostat Approved Phase 4 144060-53-7 134018
8
Nitric Oxide Approved Phase 4 10102-43-9 145068
9
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
10
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1 116094-23-6 16132418
11
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 133107-64-9
12
Insulin-glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1 207748-29-6
13
Diazoxide Approved Phase 4 364-98-7 3019
14
Glyburide Approved Phase 4,Phase 2,Phase 3 10238-21-8 3488
15
Candesartan Approved Phase 4,Phase 3 139481-59-7 2541
16
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
17
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 141758-74-9 15991534
18
Pramlintide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 151126-32-8
19
Metformin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 657-24-9 14219 4091
20
Vildagliptin Approved, Investigational Phase 4,Phase 3,Phase 2 274901-16-5 6918537
21
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
22
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 104987-11-3 445643 439492
23
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
24
Adenosine Approved, Investigational Phase 4 58-61-7 60961
25
Regadenoson Approved Phase 4 313348-27-5 219024
26
Ethanol Approved Phase 4,Phase 2,Phase 1,Early Phase 1 64-17-5 702
27
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
28
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
29
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
30
Norepinephrine Approved Phase 4 51-41-2 439260
31
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
32
Saxagliptin Approved Phase 4,Phase 3,Phase 2 361442-04-8 11243969
33
Allopurinol Approved Phase 4,Phase 3 315-30-0 2094
34
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
35
alemtuzumab Approved, Investigational Phase 4,Phase 1,Phase 2 216503-57-0
36
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
37
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
38
Gliclazide Approved Phase 4 21187-98-4 3475
39
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
40
Diphenhydramine Approved Phase 4 58-73-1, 147-24-0 3100
41
Promethazine Approved Phase 4 60-87-7 4927
42
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
43
Inulin Approved, Nutraceutical Phase 4,Early Phase 1 9005-80-5 24763
44
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 50-14-6 5280793
45
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 1406-16-2
46
Vitamin C Approved, Nutraceutical Phase 4,Phase 1 50-81-7 5785 54670067
47
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 67-97-0 6221 10883523 5280795
48 Tocopherol Approved, Nutraceutical Phase 4,Phase 3,Phase 1
49
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1 59-02-9 14985
50
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 11103-57-4, 68-26-8 445354

Interventional clinical trials:

(show top 50) (show all 2134)

id Name Status NCT ID Phase Drugs
1 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
2 52 Week Trial of Liraglutide in Type 1 Diabetes Unknown status NCT01787916 Phase 4 Liraglutide
3 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
4 Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes Unknown status NCT01280682 Phase 4 rituximab
5 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
6 The Effect of Uric Acid Lowering in Type 1 Diabetes Unknown status NCT02344602 Phase 4 Febuxostat
7 CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) Unknown status NCT01848990 Phase 4 Commercial Hylenex® recombinant (hyaluronidase human injection);Precommercial Hylenex recombinant (hyaluronidase human injection);Insulin lispro;Insulin aspart;Insulin glulisine
8 Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis Unknown status NCT01271517 Phase 4 NPH insulin;Glargine;Detemir
9 Psychosocial Issues in Insulin Pump Therapy in Children With Type 1 DM Unknown status NCT01338922 Phase 4
10 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
11 Use of Diazoxide in Acute Hypoglycaemia Unknown status NCT01488136 Phase 4 Diazoxide;Placebo
12 Dapagliflozin in Type 1 Diabetes Unknown status NCT02211742 Phase 4 Dapagliflozin
13 A Crossover Study With Hexalacton in Patients With Type 1 Diabetes and Microalbuminuria Unknown status NCT00843388 Phase 4 Spironolacton (hexalacton(R));placebo tablet
14 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
15 Diabetes Type 1, Treatment Study Atacand/Placebo After Kidney Biopsy Unknown status NCT00328302 Phase 4 Candesartan;Placebo
16 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
17 Obtain a Good Blood Glucose Control With the Paradigm Real Time System Unknown status NCT00441129 Phase 4
18 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4 liraglutide;Insulin injections
19 Vitamin D and Glucose Metabolism in Pediatrics Unknown status NCT01386736 Phase 4 Vitamin D drops;Placebo drops
20 Study to Estimate the Effects of Inhaled Versus Intravenous (IV) Infusion of Human Insulin in Subjects With Type 1 Diabetes Completed NCT00315952 Phase 4 Exubera
21 Pilot Study of the GlucoWatch G2 Biographer for the Management of Type 1 Diabetes in Children Completed NCT00069615 Phase 4
22 Clinical Trial of Efficiency and Safety of Subetta in the Combined Treatment of Patients With Type I Diabetes Mellitus Completed NCT01868594 Phase 4 Subetta;Placebo
23 Assessing Glucose Effects of Sitagliptin (Januvia) in Adult Patients With Type 1 Diabetes Completed NCT00978796 Phase 4 Sitagliptin;Sugar Pill
24 Comparison Between GLP 1 Analogues and DPP 4 Inhibitors in Type 1 Diabetes Mellitus Completed NCT01235819 Phase 4 Insulin;Sitagliptin;Exenatide
25 Randomized Clinical Trial to Assess the Effectiveness of the GlucoWatch Biographer Completed NCT00069628 Phase 4
26 Continuous Glucose Monitors for Children With Diabetes Mellitus Completed NCT00069537 Phase 4
27 Efficacy of Diazoxide in Type 1 Diabetes Completed NCT00131755 Phase 4 diazoxide
28 Post-meal Insulin Dosing With Adjuvant Pre-meal Pramlintide in Children With Type 1 Diabetes Mellitus Completed NCT00442767 Phase 4 Pramlintide acetate
29 Liraglutide in Type 1 Diabetes Completed NCT01612468 Phase 4 Liraglutide;Placebo
30 Metabolic Effects of Accurate Blood Sugar Results and Education in Type 1 Diabetes Completed NCT00284232 Phase 4 Insulin dosing based on SMBG chart and education
31 Effect of Metformin in Patients With Type-1 Diabetes With Inadequate Glycaemic Control by Insulin and Diet Completed NCT00118937 Phase 4 Metformin;Placebo.;Placebo.
32 A Pilot Study to Assess the Glucose Lowering Effect of Metformin and Sitagliptin in Adolescents With Type 1 Diabetes Completed NCT01718093 Phase 4 Sitagliptin;Metformin;Sitagliptin + Metformin
33 Effects of Aspirin Treatment on Fibrin Network Formation in Patients With Type 1 Diabetes Completed NCT01397513 Phase 4 Aspirin
34 Effects of Vitamin D Supplementation in Subjects With New Onset of Type 1 Diabetes Completed NCT01390480 Phase 4 Cholecalciferol
35 Treatment Trial Evaluating Long Acting Insulin in Type 1 Diabetes Completed NCT00276393 Phase 4 Basal insulin
36 The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1 Completed NCT01277913 Phase 4 Vitamin D3;Vitamin D3
37 Sitagliptin Dose Determination Study Completed NCT01530178 Phase 4 Sitagliptin
38 Prevention of Severe Hypoglycemia in Type 1 Diabetes Completed NCT00360984 Phase 4 insulin glargine
39 Insulin Glulisine and Aspart in Postprandial Glycemic Control After High-GI Meal in Children With Type 1 Diabetes Mellitus Completed NCT01678235 Phase 4 Insulin glulisine;Insulin aspart
40 Role of Mobile Technology to Improve Diabetes Care in Adults With Type 1 Diabetes: the REMOTE-T1D Study, a Pilot Study Completed NCT01825382 Phase 4
41 Test of the Efficacy and Safety of Insulin Glulisine Injected Subcutaneously in Patients With Type 1 Diabetes Mellitus Completed NCT00964574 Phase 4 INSULIN GLULISINE (HMR1964);INSULIN GLARGINE
42 A Study Comparing the Efficacy and Safety of the Morning Injection of Toujeo Versus Lantus in Patients With Type 1 Diabetes Mellitus Completed NCT02688933 Phase 4 Insulin glargine (U300) HOE901;Insulin glargine HOE901;Insulin glulisine HMR1964;Insulin aspart;Insulin lispro
43 Human Insulin NPH and Insulin Aspart in Type 1 Diabetes Completed NCT00597233 Phase 4 insulin aspart;soluble human insulin;insulin NPH
44 Safety and Efficacy of Insulin Aspart in Children With Type 1 Diabetes Completed NCT01467141 Phase 4 insulin aspart;human insulin;isophane human insulin
45 Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia Completed NCT01269047 Phase 4 Pramlintide;Exenatide;Insulin
46 Efficacy and Safety of Insulin Aspart in MDI or CSII in Children Below 7 Years of Age With Type 1 Diabetes Completed NCT00571935 Phase 4 insulin aspart;soluble human insulin
47 Effect of Immediate Hemoglobin A1c on Glycemic Control in Children With Type I Diabetes Mellitus Completed NCT00898534 Phase 4
48 Comparison of Insulin Detemir Given Once or Twice Daily in Type 1 Diabetes Completed NCT00117780 Phase 4 insulin detemir;insulin aspart
49 The Effect of Metformin in Overweight Patients With Dysregulated Type 1 Diabetes Mellitus Completed NCT00145379 Phase 4 Tablet Metformin 500 mg;Placebo
50 The Effect of Exercise on Blood Glucose Levels in Patients With Type 1 Diabetes: A Comparison of 3 Long-acting Insulins Completed NCT00313742 Phase 4 insulin detemir;insulin glargine;insulin NPH

Search NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Diabetes Mellitus, Insulin-Dependent cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Diabetes Mellitus, Insulin-Dependent:
Bone marrow-derived adult mesenchymal stem cells for treatment of type I diabetes
Bone marrow-derived mononuclear cells for the treatment of diabetes mellitus
Dendritic cells for type I diabetes
Dental pulp stem cell-derived islet clusters for treating diabetes
DIABECELL
Encapsulated embryonic stem cell-derived NKX6.1-positive cells for diabetes
Encapsulated embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Endothelial progenitor cell and islet cotransplantation for diabetes
Fibroblast-derived pancreatic progenitor cells for treatment of diabetes
Hematopoietic stem cell transplantation for new-onset type 1 diabetes
Hematopoietic stem cells for early-onset type I diabetes mellitus
Hematopoietic stem cells for treatment of early-onset type I diabetes mellitus
Hematopoietic stem cells for type I diabetes mellitus
Human islet transplantation to treat diabetes
Porcine embryonic pancreatic tissue transplantation for diabetes
Prochymal
Regulatory T cells for type I diabetes
Stem cell-derived pancreatic islets for diabetes treatment
StemGenex
Umbilical cord-derived mesenchymal stem cells for treatment of type I diabetes
VC-01, embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Embryonic/Adult Cultured Cells Related to Diabetes Mellitus, Insulin-Dependent:
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mononuclear cells (family)
Immunosuppressive dendritic cells PMIDs: 17665986 18552749 23148758
Mouse immunosuppressive dendritic cells PMIDs: 17665986 18552749 23148758
Islet-like cell clusters PMIDs: 23845187
Encapsulated neonatal porcine islets (DIABECELL PMIDs: 15808678 18814261 17607741 21358330 21535153 16131605 23088180 19063691 16298643 11202575 17381690
Pancreatic endoderm and endocrine precursors in cell suspension
Pancreatic endoderm/endocrine precursor-like cells PMIDs: 24788136 20587750 18834446 22623968 18034635
Mouse Islets PMIDs: 22362173
Umbilical cord blood-derived endothelial progenitor cells PMIDs: 22362173
Pancreatic islets PMIDs: 22362173
Pancreatic progenitor-like cells PMIDs: 24506886
Peripheral blood-derived hematopoietic stem cells (family) PMIDs: 23190701
Peripheral blood-derived hematopoietic stem cells PMIDs: 23190701
Peripheral blood-derived hematopoietic stem cells PMIDs: 23190701
Bone marrow-derived hematopoietic stem cells (family)
Pancreatic islets (cadavers) PMIDs: 15983207 10911004
Fetal pancreatic tissue PMIDs: 16768546 19433788
Regulatory T cells PMIDs: 15322272 16903917
Islet-like structures PMIDs: 24268157
Adipose-derived stem cells (StemGenex
Wharton-Jelly-derived mesenchymal stem cells

Cochrane evidence based reviews: diabetes mellitus, type 1

Genetic Tests for Diabetes Mellitus, Insulin-Dependent

Genetic tests related to Diabetes Mellitus, Insulin-Dependent:

id Genetic test Affiliating Genes
1 Diabetes Mellitus 29
2 Diabetes Mellitus Type 1 29

Anatomical Context for Diabetes Mellitus, Insulin-Dependent

MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent:

39
Pancreas, Kidney, Testes, Bone, Eye, Pancreatic Islet, Brain
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Diabetes Mellitus, Insulin-Dependent:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Pancreas Islets of Langerhans Mature Beta Cells Potential therapeutic candidate, affected by disease
3 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate
4 Blood Cord Blood Mesenchymal Stem Cells Potential therapeutic candidate
5 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
6 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Diabetes Mellitus, Insulin-Dependent

Articles related to Diabetes Mellitus, Insulin-Dependent:

id Title Authors Year
1
Autoantibodies to tissue transglutaminase in patients from eastern India with malnutrition-modulated diabetes mellitus, insulin-dependent diabetes mellitus, and non-insulin-dependent diabetes mellitus. ( 12021113 )
2002
2
Characterization of insulin-like growth factor-binding proteins produced by cultured fibroblasts from patients with noninsulin-dependent diabetes mellitus, insulin-dependent diabetes mellitus, or obesity. ( 7527414 )
1994