MCID: DBT085
MIFTS: 69

Diabetes Mellitus, Insulin-Dependent

Categories: Rare diseases, Endocrine diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent

MalaCards integrated aliases for Diabetes Mellitus, Insulin-Dependent:

Name: Diabetes Mellitus, Insulin-Dependent 53 24 71 37 69
Iddm 53 12 49 24 71
Type 1 Diabetes Mellitus 37 12 24 14
Diabetes Mellitus Type 1 72 49 24 28
Insulin-Dependent Diabetes Mellitus 12 49 24
Juvenile-Onset Diabetes 53 49 24
Type 1 Diabetes 49 24 59
Diabetes Mellitus, Insulin-Dependent-1 53 13
Diabetes Mellitus, Type 1 24 41
Type I Diabetes Mellitus 12 36
Jod 53 24
Diabetes Mellitus, Insulin-Dependent, Susceptibility to 13
Diabetes Mellitus, Insulin Dependent 49
Diabetes Mellitus Insulin-Dependent 51
Juvenile-Onset Diabetes Mellitus 24
Juvenile-Onset Diabetes; Jod 53
Diabetes, Insulin Dependent 72
Diabetes Mellitus, Type I 53
Diabetes, Autoimmune 69
Autoimmune Diabetes 24
Diabetes Autoimmune 51
Juvenile Diabetes 24
Diabetes Type 1 40
T1d 24

Characteristics:

OMIM:

53
Inheritance:
heterogeneous
autosomal recessive susceptibility


HPO:

31
diabetes mellitus, insulin-dependent:
Inheritance heterogeneous


Classifications:



Summaries for Diabetes Mellitus, Insulin-Dependent

PubMed Health : 59
About type 1 diabetes: Diabetes is a metabolic disease that affects many parts of the body. Depending on the type of diabetes, the body either cannot produce insulin itself (type 1) or is unable to use the insulin it produces properly (type 2). Insulin is a hormone – a chemical messenger that is transported in the blood and regulates important body functions. Without insulin your body cannot get the energy it needs from the food you have eaten.This vital hormone is usually produced in the pancreas and released into the bloodstream. Here it enables the sugar (glucose) in our food and drink to be transported into our cells and converted into energy for our bodies. Without insulin our bodies cannot use the sugar in our blood, so the sugar builds up there. Very high blood sugar concentrations cause a number of symptoms.People with type 1 diabetes have to inject insulin on a daily basis because their pancreas can only produce insulin in very small quantities, or can’t produce any insulin at all. Insulin therapy helps prevent strong fluctuations in blood sugar levels and the unpleasant effects of high and low blood sugar. It is also intended to prevent complications that may arise as a result of high blood sugar levels.

MalaCards based summary : Diabetes Mellitus, Insulin-Dependent, also known as iddm, is related to diabetes mellitus, insulin-dependent, 23 and type 1 diabetes mellitus 11, and has symptoms including polyuria, polydipsia and diabetes mellitus. An important gene associated with Diabetes Mellitus, Insulin-Dependent is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are Type I diabetes mellitus and T cell receptor signaling pathway. The drugs Insulin Detemir and Insulin Glargine have been mentioned in the context of this disorder. Affiliated tissues include Bone and Pancreas, and related phenotype is digestive/alimentary.

OMIM : 53 The type of diabetes mellitus called IDDM is a disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. It is a genetically heterogeneous autoimmune disease affecting about 0.3% of Caucasian populations (Todd, 1990). Genetic studies of IDDM have focused on the identification of loci associated with increased susceptibility to this multifactorial phenotype. The classical phenotype of diabetes mellitus is polydipsia, polyphagia, and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. (222100)

UniProtKB/Swiss-Prot : 71 Diabetes mellitus, insulin-dependent: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

NIH Rare Diseases : 49 Diabetes mellitus type 1 (DM1) is a condition in which cells in the pancreas (beta cells) stop producing insulin, causing abnormally high blood sugar levels. Lack of insulin results in the inability of the body to use glucose for energy and control the amount of sugar in the blood. DM1 can occur at any age, but usually develops by early adulthood, most often in adolescence. Symptoms of high blood sugar may include frequent urination, excessive thirst, fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. The exact cause of DM1 is unknown, but having certain "variants" of specific genes may increase a person's risk to develop the condition. A predisposition to develop DM1 runs in families, but no known inheritance pattern exists. Treatment includes blood sugar control and insulin replacement therapy. Improper control can cause recurrence of high blood sugar, or abnormally low blood sugar (hypoglycemia) during exercise or when eating is delayed. If not treated, the condition can be life-threatening. Over many years, chronic high blood sugar may be associated with a variety of complications that affect many parts of the body. Last updated: 4/25/2014

MedlinePlus : 40 Diabetes means your blood glucose, or blood sugar, levels are too high. With type 1 diabetes, your pancreas does not make insulin. Insulin is a hormone that helps glucose get into your cells to give them energy. Without insulin, too much glucose stays in your blood. Over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth. Type 1 diabetes happens most often in children and young adults but can appear at any age. Symptoms may include Being very thirsty Urinating often Feeling very hungry or tired Losing weight without trying Having sores that heal slowly Having dry, itchy skin Losing the feeling in your feet or having tingling in your feet Having blurry eyesight A blood test can show if you have diabetes. If you do, you will need to take insulin for the rest of your life. A blood test called the A1C can check to see how well you are managing your diabetes. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Genetics Home Reference : 24 Type 1 diabetes is a disorder characterized by abnormally high blood sugar levels. In this form of diabetes, specialized cells in the pancreas called beta cells stop producing insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the inability to use glucose for energy or to control the amount of sugar in the blood.

Disease Ontology : 12 A diabetes mellitus that results from the body's failure to produce insulin and has material basis in autoimmune destruction of insulin-producing beta cells of the pancreas.

Wikipedia : 72 Diabetes mellitus... more...

Related Diseases for Diabetes Mellitus, Insulin-Dependent

Diseases in the Diabetes Mellitus, Insulin-Dependent family:

Diabetes Mellitus, Insulin-Dependent, 2 Diabetes Mellitus, Insulin-Dependent, 3
Diabetes Mellitus, Insulin-Dependent, 4 Diabetes Mellitus, Insulin-Dependent, 5
Diabetes Mellitus, Insulin-Dependent, 7 Diabetes Mellitus, Insulin-Dependent, 8
Diabetes Mellitus, Insulin-Dependent, 11 Diabetes Mellitus, Insulin-Dependent, 13
Diabetes Mellitus, Insulin-Dependent, 12 Diabetes Mellitus, Insulin-Dependent, 15
Diabetes Mellitus, Insulin-Dependent, 6 Diabetes Mellitus, Insulin-Dependent, 10
Diabetes Mellitus, Insulin-Dependent, 17 Diabetes Mellitus, Insulin-Dependent, 18
Diabetes Mellitus, Insulin-Dependent, 19 Diabetes Mellitus, Insulin-Dependent, 20
Diabetes Mellitus, Insulin-Dependent, 21 Diabetes Mellitus, Insulin-Dependent, 22
Diabetes Mellitus, Insulin-Dependent, 23 Diabetes Mellitus, Insulin-Dependent, 24

Diseases related to Diabetes Mellitus, Insulin-Dependent via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus, insulin-dependent, 23 35.0 IDDM23 INS
2 type 1 diabetes mellitus 11 33.7 CTLA4 HNF1A INS
3 type 1 diabetes mellitus 13 33.7 CTLA4 GAD2 INS
4 type 1 diabetes mellitus 12 33.6 CTLA4 INS
5 type 1 diabetes mellitus 2 33.5 CTLA4 INS
6 autoimmune polyendocrine syndrome, type ii 32.6 GAD2 INS
7 diabetes mellitus, ketosis-prone 32.5 GAD2 INS
8 diabetes mellitus 31.6 CTLA4 GAD2 HNF1A INS PTPN22
9 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.5 CTLA4 FOXP3 GAD2 INS PTPN22
10 diabetes mellitus, insulin-dependent, 20 12.8
11 diabetes mellitus, insulin-dependent, 22 12.8
12 diabetes mellitus, insulin-dependent, 19 12.8
13 diabetes mellitus, insulin-dependent, 10 12.7
14 diabetes mellitus, insulin-dependent, 2 12.7
15 diabetes mellitus, insulin-dependent, 12 12.6
16 diabetes mellitus, insulin-dependent, 21 12.6
17 diabetes mellitus, insulin-dependent, 24 12.6
18 diabetes mellitus, insulin-dependent, x-linked 12.5
19 diabetes mellitus, insulin-dependent, 5 12.5
20 diabetes mellitus, insulin-dependent, 13 12.5
21 diabetes mellitus, insulin-dependent, 7 12.4
22 diabetes mellitus, insulin-dependent, 8 12.4
23 diabetes mellitus, insulin-dependent, 3 12.4
24 diabetes mellitus, insulin-dependent, 4 12.4
25 diabetes mellitus, insulin-dependent, 11 12.4
26 diabetes mellitus, insulin-dependent, 15 12.4
27 diabetes mellitus, insulin-dependent, 6 12.4
28 diabetes mellitus, insulin-dependent, 17 12.4
29 diabetes mellitus, insulin-dependent, 18 12.4
30 diabetes mellitus, noninsulin-dependent 12.2
31 histiocytosis-lymphadenopathy plus syndrome 12.2
32 type 1 diabetes mellitus 3 11.7
33 type 1 diabetes mellitus 4 11.7
34 type 1 diabetes mellitus 5 11.7
35 type 1 diabetes mellitus 6 11.7
36 type 1 diabetes mellitus 7 11.7
37 type 1 diabetes mellitus 8 11.7
38 type 1 diabetes mellitus 10 11.7
39 type 1 diabetes mellitus 15 11.7
40 type 1 diabetes mellitus 17 11.7
41 type 1 diabetes mellitus 18 11.7
42 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 11.7
43 pancreatic beta cell agenesis with neonatal diabetes mellitus 11.3
44 autonomic neuropathy 11.3
45 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 11.3
46 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 11.3
47 maturity-onset diabetes of the young 11.1
48 thiamine-responsive megaloblastic anemia syndrome 11.1
49 diabetes mellitus, permanent neonatal 10.9
50 autoimmune disease of endocrine system 10.7 CTLA4 FOXP3 PTPN22

Graphical network of the top 20 diseases related to Diabetes Mellitus, Insulin-Dependent:



Diseases related to Diabetes Mellitus, Insulin-Dependent

Symptoms & Phenotypes for Diabetes Mellitus, Insulin-Dependent

Symptoms via clinical synopsis from OMIM:

53
GU:
polyuria
hyperglycemia-induced osmotic diuresis

Endocrine:
diabetes mellitus

Metabolic:
ketoacidosis
abnormally increased gluconeogenesis
insufficient glucose disposal

GI:
polydipsia
polyphagia

Lab:
hyperglycemia
relative insulin deficiency

Immunology:
pancreatic autoimmunity


Clinical features from OMIM:

222100

Human phenotypes related to Diabetes Mellitus, Insulin-Dependent:

31 (show all 7)
# Description HPO Frequency HPO Source Accession
1 polyuria 31 HP:0000103
2 polydipsia 31 HP:0001959
3 diabetes mellitus 31 HP:0000819
4 abnormality of the immune system 31 HP:0002715
5 polyphagia 31 HP:0002591
6 hyperglycemia 31 HP:0003074
7 ketoacidosis 31 HP:0001993

UMLS symptoms related to Diabetes Mellitus, Insulin-Dependent:


polydipsia, polyuria

MGI Mouse Phenotypes related to Diabetes Mellitus, Insulin-Dependent:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 CTLA4 FOXP3 GAD2 HNF1A INS ITPR3

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent

PubMedHealth treatment related to Diabetes Mellitus, Insulin-Dependent: 59

In type 1 diabetes, the focus of treatment is to monitor blood sugar levels every day and regularly use insulin. Insulin therapy makes up for the lack of insulin in the body and lowers the concentration of sugar in the blood. It is important to avoid using too much or too little insulin, to prevent blood sugar levels from getting too low or too high. Treatment also aims to prevent long-term complications associated with diabetes as much as possible. There are different types of insulin and different treatment approaches.Blood sugar levels are not only affected by the amount of insulin you inject but also by what you eat and drink, as well as how much energy you use during physical activity. The time of day, inflammatory diseases, other medications or hormonal changes can influence your blood sugar levels too. So most people learn to finely adjust their insulin therapy according to their own body and personal habits.In order for treatment to be successful, people need to be well informed about their diabetes, manage their own therapy and have reliable medical care. But over the long term, your general health will depend on other things besides just blood sugar levels. Aspects like blood pressure can have a big effect in diabetes. Because of this, people with diabetes often take other medications as well, for example to prevent cardiovascular disease.

Drugs for Diabetes Mellitus, Insulin-Dependent (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 576)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
2
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 160337-95-1
3
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
4
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53608-75-6
5
rituximab Approved Phase 4,Phase 1,Phase 2 174722-31-7 10201696
6
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1 116094-23-6 16132418
7
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 133107-64-9
8
Insulin-glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1 207748-29-6
9
Diazoxide Approved Phase 4 364-98-7 3019
10
Glyburide Approved Phase 4,Phase 2,Phase 3 10238-21-8 3488
11
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
12
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 657311 5754
13
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 204656-20-2 44147092
14
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
15
Exenatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 141758-74-9 15991534
16
Pramlintide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 151126-32-8
17
Metformin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 657-24-9 4091 14219
18
Nitric Oxide Approved Phase 4 10102-43-9 145068
19
Vildagliptin Approved, Investigational Phase 4,Phase 3,Phase 2 274901-16-5 6918537
20
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
21
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 104987-11-3 445643 439492
22
Febuxostat Approved Phase 4 144060-53-7 134018
23
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
24
Ethanol Approved Phase 4,Phase 2,Phase 1,Early Phase 1 64-17-5 702
25
Adenosine Approved, Investigational Phase 4 58-61-7 60961
26
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
27
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
28
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
29
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
30
Norepinephrine Approved Phase 4 51-41-2 439260
31
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
32
Saxagliptin Approved Phase 4,Phase 3,Phase 2 361442-04-8 11243969
33
Allopurinol Approved Phase 4,Phase 3 315-30-0 2094
34
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
35
alemtuzumab Approved, Investigational Phase 4,Phase 1,Phase 2 216503-57-0
36
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 46507594 772
37
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
38
Gliclazide Approved Phase 4 21187-98-4 3475
39
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
40
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
41
Promethazine Approved, Investigational Phase 4 60-87-7 4927
42
Tadalafil Approved, Investigational Phase 4,Phase 1 171596-29-5 110635
43
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 10909430 439542
44
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 50-14-6 5280793
45
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 1406-16-2
46
Vitamin C Approved, Nutraceutical Phase 4,Phase 1 50-81-7 54670067 5785
47
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 67-97-0 10883523 5280795 6221
48
Inulin Approved, Investigational, Nutraceutical Phase 4,Early Phase 1 9005-80-5 24763
49 Tocopherol Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 1
50
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1 59-02-9 14985

Interventional clinical trials:

(show top 50) (show all 2215)

# Name Status NCT ID Phase Drugs
1 Comparing Long-acting Insulins During Exercise in Type 1 Diabetes Unknown status NCT01440439 Phase 4 Insulin glargine;Insulin detemir
2 Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Unknown status NCT01800734 Phase 4
3 Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes Unknown status NCT01280682 Phase 4 rituximab
4 Treatment of Low Blood Sugar With Glucagon Among Patients With Type 1 Diabetes Unknown status NCT02232971 Phase 4 Glucagon
5 CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM) Unknown status NCT01848990 Phase 4 Commercial Hylenex® recombinant (hyaluronidase human injection);Precommercial Hylenex recombinant (hyaluronidase human injection);Insulin lispro;Insulin aspart;Insulin glulisine
6 Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis Unknown status NCT01271517 Phase 4 NPH insulin;Glargine;Detemir
7 Dapagliflozin in Type 1 Diabetes Unknown status NCT02211742 Phase 4 Dapagliflozin
8 Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus Unknown status NCT01016457 Phase 4
9 A Crossover Study With Hexalacton in Patients With Type 1 Diabetes and Microalbuminuria Unknown status NCT00843388 Phase 4 Spironolacton (hexalacton(R));placebo tablet
10 Use of Diazoxide in Acute Hypoglycaemia Unknown status NCT01488136 Phase 4 Diazoxide;Placebo
11 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
12 Obtain a Good Blood Glucose Control With the Paradigm Real Time System Unknown status NCT00441129 Phase 4
13 Diabetes Type 1, Treatment Study Atacand/Placebo After Kidney Biopsy Unknown status NCT00328302 Phase 4 Candesartan;Placebo
14 Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose Unknown status NCT00145353 Phase 4 Insulin NovoRapid versus Actrapid
15 GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients Unknown status NCT01592279 Phase 4 liraglutide;Insulin injections
16 Vitamin D and Glucose Metabolism in Pediatrics Unknown status NCT01386736 Phase 4 Vitamin D drops;Placebo drops
17 ASCEND: A Study of Cardiovascular Events iN Diabetes Unknown status NCT00135226 Phase 4 aspirin;Omega-3-acid Ethyl Esters;Placebo Aspirin;Placebo omega-3-Ethyl Esters
18 Study to Estimate the Effects of Inhaled Versus Intravenous (IV) Infusion of Human Insulin in Subjects With Type 1 Diabetes Completed NCT00315952 Phase 4 Exubera
19 Clinical Trial of Efficiency and Safety of Subetta in the Combined Treatment of Patients With Type I Diabetes Mellitus Completed NCT01868594 Phase 4 Subetta;Placebo
20 Assessing Glucose Effects of Sitagliptin (Januvia) in Adult Patients With Type 1 Diabetes Completed NCT00978796 Phase 4 Sitagliptin;Sugar Pill
21 Pilot Study of the GlucoWatch G2 Biographer for the Management of Type 1 Diabetes in Children Completed NCT00069615 Phase 4
22 Comparison Between GLP 1 Analogues and DPP 4 Inhibitors in Type 1 Diabetes Mellitus Completed NCT01235819 Phase 4 Insulin;Sitagliptin;Exenatide
23 52 Week Trial of Liraglutide in Type 1 Diabetes Completed NCT01787916 Phase 4 Liraglutide;Placebos
24 Efficacy of Diazoxide in Type 1 Diabetes Completed NCT00131755 Phase 4 diazoxide
25 Liraglutide in Type 1 Diabetes Completed NCT01612468 Phase 4 Liraglutide;Placebo
26 Post-meal Insulin Dosing With Adjuvant Pre-meal Pramlintide in Children With Type 1 Diabetes Mellitus Completed NCT00442767 Phase 4 Pramlintide acetate
27 A Pilot Study to Assess the Glucose Lowering Effect of Metformin and Sitagliptin in Adolescents With Type 1 Diabetes Completed NCT01718093 Phase 4 Sitagliptin;Metformin;Sitagliptin + Metformin
28 Effects of Aspirin Treatment on Fibrin Network Formation in Patients With Type 1 Diabetes Completed NCT01397513 Phase 4 Aspirin
29 Effects of Vitamin D Supplementation in Subjects With New Onset of Type 1 Diabetes Completed NCT01390480 Phase 4 Cholecalciferol
30 The Effect of Uric Acid Lowering in Type 1 Diabetes Completed NCT02344602 Phase 4 Febuxostat
31 Role of Mobile Technology to Improve Diabetes Care in Adults With Type 1 Diabetes: the REMOTE-T1D Study, a Pilot Study Completed NCT01825382 Phase 4
32 Sitagliptin Dose Determination Study Completed NCT01530178 Phase 4 Sitagliptin
33 Insulin Glulisine and Aspart in Postprandial Glycemic Control After High-GI Meal in Children With Type 1 Diabetes Mellitus Completed NCT01678235 Phase 4 Insulin glulisine;Insulin aspart
34 The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1 Completed NCT01277913 Phase 4 Vitamin D3;Vitamin D3
35 A Study Comparing the Efficacy and Safety of the Morning Injection of Toujeo Versus Lantus in Patients With Type 1 Diabetes Mellitus Completed NCT02688933 Phase 4 Insulin glargine (U300) HOE901;Insulin glargine HOE901;Insulin glulisine HMR1964;Insulin aspart;Insulin lispro
36 Metabolic Effects of Accurate Blood Sugar Results and Education in Type 1 Diabetes Completed NCT00284232 Phase 4 Insulin dosing based on SMBG chart and education
37 Effect of Metformin in Patients With Type-1 Diabetes With Inadequate Glycaemic Control by Insulin and Diet Completed NCT00118937 Phase 4 Metformin;Placebo.;Placebo.
38 Treatment Trial Evaluating Long Acting Insulin in Type 1 Diabetes Completed NCT00276393 Phase 4 Basal insulin
39 Test of the Efficacy and Safety of Insulin Glulisine Injected Subcutaneously in Patients With Type 1 Diabetes Mellitus Completed NCT00964574 Phase 4 INSULIN GLULISINE (HMR1964);INSULIN GLARGINE
40 Prevention of Severe Hypoglycemia in Type 1 Diabetes Completed NCT00360984 Phase 4 insulin glargine
41 Randomized Clinical Trial to Assess the Effectiveness of the GlucoWatch Biographer Completed NCT00069628 Phase 4
42 Continuous Glucose Monitors for Children With Diabetes Mellitus Completed NCT00069537 Phase 4
43 Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia Completed NCT01269047 Phase 4 Pramlintide;Exenatide;Insulin
44 Safety and Efficacy of Insulin Aspart in Children With Type 1 Diabetes Completed NCT01467141 Phase 4 insulin aspart;human insulin;isophane human insulin
45 Human Insulin NPH and Insulin Aspart in Type 1 Diabetes Completed NCT00597233 Phase 4 insulin aspart;soluble human insulin;insulin NPH
46 Effect of Immediate Hemoglobin A1c on Glycemic Control in Children With Type I Diabetes Mellitus Completed NCT00898534 Phase 4
47 The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes Completed NCT02881060 Phase 4
48 Efficacy and Safety of Insulin Aspart in MDI or CSII in Children Below 7 Years of Age With Type 1 Diabetes Completed NCT00571935 Phase 4 insulin aspart;soluble human insulin
49 Regadenoson Blood Flow in Type 1 Diabetes (RABIT1D) Completed NCT01019486 Phase 4 Regadenoson myocardial perfusion imaging;Regadenoson MRI myocardial blood flow
50 Comparison of Insulin Detemir Given Once or Twice Daily in Type 1 Diabetes Completed NCT00117780 Phase 4 insulin detemir;insulin aspart

Search NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Diabetes Mellitus, Insulin-Dependent cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Diabetes Mellitus, Insulin-Dependent:
Bone marrow-derived adult mesenchymal stem cells for treatment of type I diabetes
Bone marrow-derived mononuclear cells for the treatment of diabetes mellitus
Dendritic cells for type I diabetes
Dental pulp stem cell-derived islet clusters for treating diabetes
DIABECELL
Encapsulated embryonic stem cell-derived NKX6.1-positive cells for diabetes
Encapsulated embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Endothelial progenitor cell and islet cotransplantation for diabetes
Fibroblast-derived pancreatic progenitor cells for treatment of diabetes
Hematopoietic stem cell transplantation for new-onset type 1 diabetes
Hematopoietic stem cells for early-onset type I diabetes mellitus
Hematopoietic stem cells for treatment of early-onset type I diabetes mellitus
Hematopoietic stem cells for type I diabetes mellitus
Human islet transplantation to treat diabetes
Porcine embryonic pancreatic tissue transplantation for diabetes
Prochymal
Regulatory T cells for type I diabetes
Stem cell-derived pancreatic islets for diabetes treatment
StemGenex
Umbilical cord-derived mesenchymal stem cells for treatment of type I diabetes
VC-01, embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes
Embryonic/Adult Cultured Cells Related to Diabetes Mellitus, Insulin-Dependent:
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mononuclear cells (family)
Immunosuppressive dendritic cells PMIDs: 17665986 18552749 23148758
Mouse immunosuppressive dendritic cells PMIDs: 17665986 18552749 23148758
Islet-like cell clusters PMIDs: 23845187
Encapsulated neonatal porcine islets (DIABECELL PMIDs: 15808678 18814261 17607741 21358330 21535153 16131605 23088180 19063691 16298643 11202575 17381690
Pancreatic endoderm and endocrine precursors in cell suspension
Pancreatic endoderm/endocrine precursor-like cells PMIDs: 24788136 20587750 18834446 22623968 18034635
Mouse Islets PMIDs: 22362173
Umbilical cord blood-derived endothelial progenitor cells PMIDs: 22362173
Pancreatic islets PMIDs: 22362173
Pancreatic progenitor-like cells PMIDs: 24506886
Peripheral blood-derived hematopoietic stem cells (family) PMIDs: 23190701
Peripheral blood-derived hematopoietic stem cells PMIDs: 23190701
Peripheral blood-derived hematopoietic stem cells PMIDs: 23190701
Bone marrow-derived hematopoietic stem cells (family)
Pancreatic islets (cadavers) PMIDs: 15983207 10911004
Fetal pancreatic tissue PMIDs: 16768546 19433788
Regulatory T cells PMIDs: 15322272 16903917
Islet-like structures PMIDs: 24268157
Adipose-derived stem cells (StemGenex
Wharton-Jelly-derived mesenchymal stem cells

Cochrane evidence based reviews: diabetes mellitus, type 1

Genetic Tests for Diabetes Mellitus, Insulin-Dependent

Genetic tests related to Diabetes Mellitus, Insulin-Dependent:

# Genetic test Affiliating Genes
1 Diabetes Mellitus Type 1 28 FOXP3 HNF1A ITPR3 OAS1 PTPN22

Anatomical Context for Diabetes Mellitus, Insulin-Dependent

MalaCards organs/tissues related to Diabetes Mellitus, Insulin-Dependent:

38
Pancreas, Kidney, Testes, Bone, Brain, Eye, Pancreatic Islet
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Diabetes Mellitus, Insulin-Dependent:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Pancreas Islets of Langerhans Mature Beta Cells Potential therapeutic candidate, affected by disease
3 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate
4 Blood Cord Blood Mesenchymal Stem Cells Potential therapeutic candidate
5 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
6 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Diabetes Mellitus, Insulin-Dependent

Articles related to Diabetes Mellitus, Insulin-Dependent:

# Title Authors Year
1
Autoantibodies to tissue transglutaminase in patients from eastern India with malnutrition-modulated diabetes mellitus, insulin-dependent diabetes mellitus, and non-insulin-dependent diabetes mellitus. ( 12021113 )
2002
2
Characterization of insulin-like growth factor-binding proteins produced by cultured fibroblasts from patients with noninsulin-dependent diabetes mellitus, insulin-dependent diabetes mellitus, or obesity. ( 7527414 )
1994

Variations for Diabetes Mellitus, Insulin-Dependent

UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Insulin-Dependent:

71
# Symbol AA change Variation ID SNP ID
1 PTPN22 p.Arg620Trp VAR_022605 rs2476601

ClinVar genetic disease variations for Diabetes Mellitus, Insulin-Dependent:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HNF1A NM_000545.6(HNF1A): c.872dupC (p.Gly292Argfs) duplication Pathogenic rs587776825 GRCh37 Chromosome 12, 121432125: 121432125
2 HNF1A NM_000545.6(HNF1A): c.608G> A (p.Arg203His) single nucleotide variant Likely pathogenic rs587780357 GRCh37 Chromosome 12, 121431404: 121431404
3 FOXP3 NM_014009.3(FOXP3): c.398C> T (p.Pro133Leu) single nucleotide variant Likely pathogenic rs782511378 GRCh37 Chromosome X, 49113940: 49113940

Copy number variations for Diabetes Mellitus, Insulin-Dependent from CNVD:

7 (show all 23)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 71429 12 69818942 132349534 Copy number Type 1 diabetes
2 73895 12 98319424 98322865 Deletion ANKS1B Type 1 diabetes
3 79407 13 71375556 71378557 Deletion Type 1 diabetes
4 89486 15 18491920 19803369 Amplification or del etion BCL8 Type 1 diabetes
5 89487 15 18491920 19803369 Amplification or del etion GOLGA6L6 Type 1 diabetes
6 89488 15 18491920 19803369 Amplification or del etion GOLGA8C Type 1 diabetes
7 89489 15 18491920 19803369 Amplification or del etion POTEB Type 1 diabetes
8 107144 17 1225928 31649843 Copy number CCL3L1 Type 1 diabetes
9 107422 17 15483886 15487515 Deletion TRIM16 Type 1 diabetes
10 107551 17 15900000 22100000 Microdeletion Type 1 diabetes
11 110284 17 31800000 38100000 Copy number CCL3L1 Type 1 diabetes
12 112712 17 40930407 78774742 Copy number Type 1 diabetes
13 139339 2 179004449 242951149 Copy number Type 1 diabetes
14 149142 2 87600933 87609093 Deletion NCRNA00152 Type 1 diabetes
15 195357 5 150157836 180857866 Copy number Type 1 diabetes
16 195377 5 150183562 180857866 Copy number Type 1 diabetes
17 210791 6 31416574 170899992 Copy number Type 1 diabetes
18 211341 6 32582950 170899992 Copy number Type 1 diabetes
19 211387 6 32609209 170899992 Copy number Type 1 diabetes
20 211460 6 32700999 32710085 Deletion Type 1 diabetes
21 220035 7 133435735 133449694 Deletion Type 1 diabetes
22