MCID: DBT074
MIFTS: 22

Diabetes, Mellitus, Insulin-Dependent 10

Categories: Genetic diseases

Aliases & Classifications for Diabetes, Mellitus, Insulin-Dependent 10

MalaCards integrated aliases for Diabetes, Mellitus, Insulin-Dependent 10:

Name: Diabetes, Mellitus, Insulin-Dependent 10 54
Diabetes Mellitus, Insulin-Dependent, 10 71 29 69
Diabetes, Mellitus, Insulin-Dependent, Susceptibility to, 10 13
Iddm10 71

Characteristics:

OMIM:

54
Inheritance:
autosomal locus and allelic heterogeneity


Classifications:



External Ids:

OMIM 54 601942
MedGen 40 C1866040
MeSH 42 D003922
SNOMED-CT via HPO 65 73211009

Summaries for Diabetes, Mellitus, Insulin-Dependent 10

UniProtKB/Swiss-Prot : 71 Diabetes mellitus, insulin-dependent, 10: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

MalaCards based summary : Diabetes, Mellitus, Insulin-Dependent 10, also known as diabetes mellitus, insulin-dependent, 10, is related to type 1 diabetes mellitus 10, and has symptoms including diabetes mellitus An important gene associated with Diabetes, Mellitus, Insulin-Dependent 10 is IL2RA (Interleukin 2 Receptor Subunit Alpha). The drugs Anticholesteremic Agents and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include kidney, eye and pancreatic islet.

Description from OMIM: 601942

Related Diseases for Diabetes, Mellitus, Insulin-Dependent 10

Diseases related to Diabetes, Mellitus, Insulin-Dependent 10 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 type 1 diabetes mellitus 10 10.8

Symptoms & Phenotypes for Diabetes, Mellitus, Insulin-Dependent 10

Symptoms via clinical synopsis from OMIM:

54

Endocrine:
diabetes mellitus, insulin-dependent


Clinical features from OMIM:

601942

Human phenotypes related to Diabetes, Mellitus, Insulin-Dependent 10:

32
id Description HPO Frequency HPO Source Accession
1 diabetes mellitus 32 HP:0000819

Drugs & Therapeutics for Diabetes, Mellitus, Insulin-Dependent 10

Drugs for Diabetes, Mellitus, Insulin-Dependent 10 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anticholesteremic Agents Phase 3
2 Antimetabolites Phase 3
3 Atorvastatin Calcium Phase 3 134523-03-8
4 Calcium, Dietary Phase 3
5 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
6 Hypolipidemic Agents Phase 3
7 Lipid Regulating Agents Phase 3
8
Abatacept Approved Phase 1, Phase 2 332348-12-6 10237
9
rituximab Approved Phase 2 174722-31-7 10201696
10
Liraglutide Approved Phase 2 204656-20-2 44147092
11 insulin Phase 1, Phase 2
12 Insulin, Globin Zinc Phase 1, Phase 2
13 Hypoglycemic Agents Phase 2
14 Antirheumatic Agents Phase 1, Phase 2
15 Immunosuppressive Agents Phase 1, Phase 2
16 Antibodies Phase 2
17 Antibodies, Monoclonal Phase 2
18 Immunoglobulins Phase 2
19 Glucagon-Like Peptide 1 Phase 2
20 Hormone Antagonists Phase 2
21 Hormones Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
23 Incretins Phase 2
24 Autoantibodies Phase 2
25
Insulin Glargine Approved 160337-95-1
26
Zinc Approved 7440-66-6 32051 23994
27
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
28
Pancrelipase Approved 53608-75-6
29
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
30
Benzocaine Approved 1994-09-7, 94-09-7 2337
31 tannic acid Approved, Nutraceutical
32 Antifungal Agents
33 Anti-Infective Agents
34 Calcineurin Inhibitors
35 Cyclosporins
36 Dermatologic Agents
37 pancreatin

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 Statins in Children With Type 1 Diabetes and Hypercholesterolemia Completed NCT01236365 Phase 3 Atorvastatin;Atorvastatin Placebo
2 Prevention of Autoimmune Destruction and Rejection of Human Pancreatic Islets Following Transplantation for Insulin Dependent Diabetes Mellitus Completed NCT00501709 Phase 1, Phase 2 Belatacept
3 Rituximab in New Onset Type 1 Diabetes Completed NCT00279305 Phase 2 Anti-CD20 (rituximab);Placebo Comparator
4 Incretin-based Therapy in Early Diagnosed Type 1 Diabetes Enrolling by invitation NCT02908087 Phase 2 Victoza® (liraglutide);Placebo
5 Incretin-based Therapy in Late Preclinical Type 1 Diabetes Enrolling by invitation NCT02898506 Phase 2 Victoza®;Placebo
6 Transplantation of Pancreatic Islets in Patients With Type 1 Diabetes Mellitus and Functional Kidney Graft Terminated NCT00639600 Phase 1, Phase 2
7 Prevalence of DRP and DME Among Type 1 Diabetics Treated With Long-term Intensified Insulin Therapy Unknown status NCT02307110
8 Insulin Pump Therapy in Adolescents With Newly Diagnosed Type 1 Diabetes (T1D) Completed NCT00357890 Multiple daily injections (MDI) using insulin glargine + rapid acting analog
9 Markers and Mechanisms of Macrovascular Disease in IDDM Completed NCT00005474
10 Studies of Organ Transplantation in Animals and Man Completed NCT00156364
11 Predicting Hypoglycaemia and Arrhythmias in the Patient With Diabetes and CKD - Validation Study Completed NCT02778269
12 Impact of Different Types of Exercise Training on Biochemical Markers of Insulin-dependent Patients Recruiting NCT02939768
13 TRIGR - Primary Prevention Study for Type 1 Diabetes in Children at Risk Active, not recruiting NCT00179777
14 Information and Communication Technology Based Centralized Clinical Trial Monitoring System for Insulin Dose Adjustment Not yet recruiting NCT03112343
15 Choroidal Blood Flow Changes During Dark/Light Transitions in Patients With Insulin-dependent Diabetes Mellitus (IDDM) Terminated NCT00718614

Search NIH Clinical Center for Diabetes, Mellitus, Insulin-Dependent 10

Genetic Tests for Diabetes, Mellitus, Insulin-Dependent 10

Genetic tests related to Diabetes, Mellitus, Insulin-Dependent 10:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Insulin-Dependent, 10 29

Anatomical Context for Diabetes, Mellitus, Insulin-Dependent 10

MalaCards organs/tissues related to Diabetes, Mellitus, Insulin-Dependent 10:

39
Kidney, Eye, Pancreatic Islet

Publications for Diabetes, Mellitus, Insulin-Dependent 10

Variations for Diabetes, Mellitus, Insulin-Dependent 10

Expression for Diabetes, Mellitus, Insulin-Dependent 10

Search GEO for disease gene expression data for Diabetes, Mellitus, Insulin-Dependent 10.

Pathways for Diabetes, Mellitus, Insulin-Dependent 10

GO Terms for Diabetes, Mellitus, Insulin-Dependent 10

Sources for Diabetes, Mellitus, Insulin-Dependent 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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