IDDM10
MCID: DBT074
MIFTS: 21

Diabetes, Mellitus, Insulin-Dependent 10 (IDDM10) malady

Categories: Genetic diseases

Aliases & Classifications for Diabetes, Mellitus, Insulin-Dependent 10

Aliases & Descriptions for Diabetes, Mellitus, Insulin-Dependent 10:

Name: Diabetes, Mellitus, Insulin-Dependent 10 54
Diabetes Mellitus, Insulin-Dependent, 10 66 29 69
Diabetes, Mellitus, Insulin-Dependent, Susceptibility to, 10 13
Iddm10 66

Classifications:



External Ids:

OMIM 54 601942
MedGen 40 C1866040
MeSH 42 D003922

Summaries for Diabetes, Mellitus, Insulin-Dependent 10

UniProtKB/Swiss-Prot : 66 Diabetes mellitus, insulin-dependent, 10: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

MalaCards based summary : Diabetes, Mellitus, Insulin-Dependent 10, also known as diabetes mellitus, insulin-dependent, 10, is related to type 1 diabetes mellitus 10, and has symptoms including diabetes mellitus An important gene associated with Diabetes, Mellitus, Insulin-Dependent 10 is IL2RA (Interleukin 2 Receptor Subunit Alpha). The drugs insulin and Insulin, Globin Zinc have been mentioned in the context of this disorder. Affiliated tissues include eye and kidney.

Description from OMIM: 601942

Related Diseases for Diabetes, Mellitus, Insulin-Dependent 10

Diseases related to Diabetes, Mellitus, Insulin-Dependent 10 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 type 1 diabetes mellitus 10 11.3

Symptoms & Phenotypes for Diabetes, Mellitus, Insulin-Dependent 10

Symptoms by clinical synopsis from OMIM:

601942

Clinical features from OMIM:

601942

Human phenotypes related to Diabetes, Mellitus, Insulin-Dependent 10:

32
id Description HPO Frequency HPO Source Accession
1 diabetes mellitus 32 HP:0000819

Drugs & Therapeutics for Diabetes, Mellitus, Insulin-Dependent 10

Drugs for Diabetes, Mellitus, Insulin-Dependent 10 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 insulin Phase 4,Phase 1,Phase 2
2 Insulin, Globin Zinc Phase 4,Phase 1,Phase 2
3 Atorvastatin Calcium Phase 3 134523-03-8
4 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
5 Hypolipidemic Agents Phase 3
6 Anticholesteremic Agents Phase 3
7 Lipid Regulating Agents Phase 3
8 Antimetabolites Phase 3
9 Calcium, Dietary Phase 3
10
rituximab Approved Phase 2 174722-31-7 10201696
11
Abatacept Approved Phase 1, Phase 2 332348-12-6 10237
12
Ibuprofen Approved Phase 2 15687-27-1 3672
13
Liraglutide Approved Phase 2 204656-20-2
14
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
15 Hypoglycemic Agents Phase 2
16 Immunoglobulins Phase 2
17 Antibodies, Monoclonal Phase 2
18 Immunosuppressive Agents Phase 1, Phase 2
19 Antibodies Phase 2
20 Antirheumatic Agents Phase 1, Phase 2
21 vitamin d Phase 2
22 Analgesics Phase 2
23 Adjuvants, Immunologic Phase 2
24 Cyclooxygenase Inhibitors Phase 2
25 Aluminum sulfate Phase 2
26 Analgesics, Non-Narcotic Phase 2
27 Trace Elements Phase 2
28 Peripheral Nervous System Agents Phase 2
29 Ergocalciferols Phase 2
30 Vitamins Phase 2
31 Anti-Inflammatory Agents Phase 2
32 Anti-Inflammatory Agents, Non-Steroidal Phase 2
33 Micronutrients Phase 2
34 Bone Density Conservation Agents Phase 2
35 Glucagon-Like Peptide 1 Phase 2
36 Hormone Antagonists Phase 2
37 Hormones Phase 2
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
39 Incretins Phase 2
40 Autoantibodies Phase 2
41 Vitamin D2 Nutraceutical Phase 2
42 Calciferol Nutraceutical Phase 2
43
Zinc Approved 7440-66-6 32051 23994
44
Cyclosporine Approved, Investigational, Vet_approved 79217-60-0, 59865-13-3 5284373 6435893
45
Tacrolimus Approved, Investigational 104987-11-3 445643 439492
46
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
47
Insulin Glargine Approved 160337-95-1
48
Pancrelipase Approved 53608-75-6
49
Benzocaine Approved 1994-09-7, 94-09-7 2337
50 tannic acid Approved, Nutraceutical

Interventional clinical trials:

(show all 18)
id Name Status NCT ID Phase
1 Obtain a Good Blood Glucose Control With the Paradigm Real Time System Unknown status NCT00441129 Phase 4
2 Statins in Children With Type 1 Diabetes and Hypercholesterolemia Completed NCT01236365 Phase 3
3 TRIGR - Primary Prevention Study for Type 1 Diabetes in Children at Risk Unknown status NCT00179777 Phase 2
4 Prevention of Autoimmune Destruction and Rejection of Human Pancreatic Islets Following Transplantation for Insulin Dependent Diabetes Mellitus Completed NCT00501709 Phase 1, Phase 2
5 Rituximab in New Onset Type 1 Diabetes Completed NCT00279305 Phase 2
6 DIABGAD - Trial to Preserve Insulin Secretion in Type 1 Diabetes Using GAD-Alum (Diamyd) in Combination With Vitamin D and Ibuprofen Active, not recruiting NCT01785108 Phase 2
7 Incretin-based Therapy in Early Diagnosed Type 1 Diabetes Enrolling by invitation NCT02908087 Phase 2
8 Incretin-based Therapy in Late Preclinical Type 1 Diabetes Enrolling by invitation NCT02898506 Phase 2
9 Transplantation of Pancreatic Islets in Patients With Type 1 Diabetes Mellitus and Functional Kidney Graft Terminated NCT00639600 Phase 1, Phase 2
10 Prevalence of DRP and DME Among Type 1 Diabetics Treated With Long-term Intensified Insulin Therapy Unknown status NCT02307110
11 Insulin Pump Therapy in Adolescents With Newly Diagnosed Type 1 Diabetes (T1D) Completed NCT00357890
12 Markers and Mechanisms of Macrovascular Disease in IDDM Completed NCT00005474
13 Studies of Organ Transplantation in Animals and Man Completed NCT00156364
14 Predicting Hypoglycaemia and Arrhythmias in the Patient With Diabetes and CKD - Validation Study Completed NCT02778269
15 Accuracy Characterization Study Completed NCT01932944
16 Impact of Different Types of Exercise Training on Biochemical Markers of Insulin-dependent Patients Recruiting NCT02939768
17 Information and Communication Technology Based Centralized Clinical Trial Monitoring System for Insulin Dose Adjustment Not yet recruiting NCT03112343
18 Choroidal Blood Flow Changes During Dark/Light Transitions in Patients With Insulin-dependent Diabetes Mellitus (IDDM) Terminated NCT00718614

Search NIH Clinical Center for Diabetes, Mellitus, Insulin-Dependent 10

Genetic Tests for Diabetes, Mellitus, Insulin-Dependent 10

Genetic tests related to Diabetes, Mellitus, Insulin-Dependent 10:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Insulin-Dependent, 10 29

Anatomical Context for Diabetes, Mellitus, Insulin-Dependent 10

MalaCards organs/tissues related to Diabetes, Mellitus, Insulin-Dependent 10:

39
Eye, Kidney

Publications for Diabetes, Mellitus, Insulin-Dependent 10

Variations for Diabetes, Mellitus, Insulin-Dependent 10

Expression for Diabetes, Mellitus, Insulin-Dependent 10

Search GEO for disease gene expression data for Diabetes, Mellitus, Insulin-Dependent 10.

Pathways for Diabetes, Mellitus, Insulin-Dependent 10

GO Terms for Diabetes, Mellitus, Insulin-Dependent 10

Sources for Diabetes, Mellitus, Insulin-Dependent 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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