MCID: DBT040
MIFTS: 16

Diabetes Mellitus, Insulin-Dependent, 2 malady

Genetic diseases (common) category
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Summaries for Diabetes Mellitus, Insulin-Dependent, 2

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MalaCards based summary: Diabetes Mellitus, Insulin-Dependent, 2 is related to permanent neonatal diabetes mellitus and diabetes mellitus. An important gene associated with Diabetes Mellitus, Insulin-Dependent, 2 is INS (insulin). The compounds testosterone and protamine have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and cellular.

Description from OMIM:46 125852

Aliases & Classifications for Diabetes Mellitus, Insulin-Dependent, 2

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Diabetes Mellitus, Insulin-Dependent, 2, Aliases & Descriptions:

Name: Diabetes Mellitus, Insulin-Dependent, 2 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Diabetes Mellitus, Insulin-Dependent, 2

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Symptoms for Diabetes Mellitus, Insulin-Dependent, 2

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Clinical features from OMIM:

125852

Drugs & Therapeutics for Diabetes Mellitus, Insulin-Dependent, 2

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Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus, Insulin-Dependent, 2

Search NIH Clinical Center for Diabetes Mellitus, Insulin-Dependent, 2

Genetic Tests for Diabetes Mellitus, Insulin-Dependent, 2

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Anatomical Context for Diabetes Mellitus, Insulin-Dependent, 2

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Animal Models for Diabetes Mellitus, Insulin-Dependent, 2 or affiliated genes

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MGI Mouse Phenotypes related to Diabetes Mellitus, Insulin-Dependent, 2:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6HPS1, INS, ZBTB16
2MP:00053848.6HPS1, INS, ZBTB16
3MP:00053978.5HPS1, INS, ZBTB16
4MP:00053878.3ZBTB16, INS, HPS1

Publications for Diabetes Mellitus, Insulin-Dependent, 2

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Variations for Diabetes Mellitus, Insulin-Dependent, 2

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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Insulin-Dependent, 2:

64
id Symbol AA change Variation ID SNP ID
1INSp.Arg55CysVAR_063732rs121908261

Clinvar genetic disease variations for Diabetes Mellitus, Insulin-Dependent, 2:

6
id Gene Name Type Significance SNP ID Assembly Location
1NM_000207.2(INS): c.163C> T (p.Arg55Cys)single nucleotide variantPathogenicrs121908261GRCh37Chr 11, 2182039: 2182039
2NM_000207.2(INS): c.94G> A (p.Gly32Ser)single nucleotide variantPathogenicrs80356664GRCh37Chr 11, 2182108: 2182108

Expression for genes affiliated with Diabetes Mellitus, Insulin-Dependent, 2

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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus, Insulin-Dependent, 2

Search GEO for disease gene expression data for Diabetes Mellitus, Insulin-Dependent, 2.

Pathways for genes affiliated with Diabetes Mellitus, Insulin-Dependent, 2

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Compounds for genes affiliated with Diabetes Mellitus, Insulin-Dependent, 2

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Sources:
44Novoseek, 61Tocris Bioscience, 24HMDB, 11DrugBank
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Compounds related to Diabetes Mellitus, Insulin-Dependent, 2 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1testosterone44 61 24 1112.4INS, ZBTB16
2protamine448.8HPS1, INS

GO Terms for genes affiliated with Diabetes Mellitus, Insulin-Dependent, 2

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Molecular functions related to Diabetes Mellitus, Insulin-Dependent, 2 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.4INS, ZBTB16

Products for genes affiliated with Diabetes Mellitus, Insulin-Dependent, 2

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  • Antibodies
  • Proteins
  • Lysates

Sources for Diabetes Mellitus, Insulin-Dependent, 2

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet