Diabetes Mellitus, Noninsulin-dependent malady

MalaCards: Diabetes Mellitus, Noninsulin-dependent, also known as diabetes mellitus, is related to type 1 diabetes mellitus and neonatal diabetes mellitus. An important gene associated with Diabetes Mellitus, Noninsulin-dependent is SLC30A8 (solute carrier family 30 (zinc transporter), member 8), and among its related pathways are Selected targets of HNF1 and Glucose transport. The drug chromium picolinate and the compounds 3-o-methylglucose and nnmt have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

OMIM: 125853

diabetes mellitus, noninsulin-dependent 33 diabetes mellitus 43

Disease types for diabetes mellitus, noninsulin-dependent family:

diabetes mellitus, noninsulin-dependent 1	diabetes mellitus, noninsulin-dependent, 2

Diseases related to diabetes mellitus, noninsulin-dependent by text searches and GeneDecks gene sharing:

(show top 50)    (show all 370)

id	Related Disease	Score	Top Affiliating Genes
1	type 1 diabetes mellitus	39.7	GCK, SLC30A8, NEUROD1, HNF1A
2	neonatal diabetes mellitus	35.7	SLC2A2, ABCC8, HNF1B, GCK
3	diabetes mellitus	35.0	LIPC, GCGR, GCK, RETN, NIDDM3, NIDDM2
4	permanent neonatal diabetes mellitus	34.8	GCK, ABCC8
5	gestational diabetes	34.5	RETN, CAPN10, GCK, IRS1, IRS2, HNF1A
6	hypertension	34.2	RETN, GCK, LIPC, GCGR, IRS1, IRS2
7	type 2 diabetes mellitus	34.1	HNF1B, HNF4A, ABCC8, SLC30A8, SLC2A4, SLC2A2
8	nephropathy	34.1	SLC2A2, NEUROD1, IRS1, GCK, HNF4A, HNF1B
9	coronary heart disease	33.4	IRS1, HNF1A, SLC30A8, RETN, CAPN10, LIPC
10	diabetes mellitus, noninsulin-dependent, 2	33.3	NIDDM2, HNF1A
11	hypoglycemia	32.1	SLC2A4, ABCC8, HNF4A, GCGR, GCK, SLC2A2
12	lipoatrophic diabetes	31.5	RETN, IRS1
13	hyperlipidemia	31.3	LIPC, GCK, RETN, IRS1
14	retinol binding protein	31.1	HNF4A, RETN, LIPC, IRS1, HNF1A, SLC2A4
15	polycystic ovary syndrome	31.0	IRS1, CAPN10, IRS2
16	hypercholesterolemia	30.9	LIPC, RETN, CAPN10, IRS2
17	obesity, association with	30.9	RETN, CAPN10, HNF1A, SLC2A4
18	pancreatic agenesis	30.6	GCK, ABCC8
19	maturity-onset diabetes of the young, type 3	30.5	HNF4A, HNF1A
20	maturity-onset diabetes of the young	30.5	HNF1A, NEUROD1, SLC2A2, GCK, IRS1, HNF1B
21	fatty liver disease	30.4	RETN, LIPC, HNF4A, IRS2
22	thyroiditis	30.4	HNF4A, HNF1B, HNF1A, SLC2A2, MAPK8IP1, LIPC
23	hypertriglyceridemia	30.2	IRS1, LIPC, SLC2A4, CAPN10
24	hyperandrogenism	30.2	RETN, IRS1, IRS2, CAPN10
25	atherosclerosis	29.7	SLC30A8, SLC2A4, RETN, GCK, LIPC, CDKAL1
26	obesity	29.6	HNF1B, HNF1A, CAPN10, IGF2BP2, IRS2, IRS1
27	hepatitis	29.6	SLC2A4, GCK, GCGR, IRS1, IRS2, CAPN10
28	insulin resistance	29.4	RETN, NIDDM3, ABCC8, SLC30A8, SLC2A4, SLC2A2
29	cholesterol	29.2	GCK, LIPC, IRS1, RETN, HNF1A, SLC2A4
30	essential hypertension	29.2	RETN, GCGR, CAPN10, SLC2A4, IRS1, IRS2
31	glucose intolerance	29.0	IRS2, NEUROD1, RETN, GCK, IRS1, CAPN10
32	hyperglycemia	28.9	NEUROD1, RETN, GCK, GCGR, LIPC, IRS1
33	twinning	28.6	RETN, IRS2, GCK, HNF1B, ABCC8, SLC2A4
34	arterial calcification	28.5	IGF2BP2, SLC30A8, CDKAL1
35	insulinoma	28.4	HNF4A, WFS1, NEUROD1, SLC2A2, SLC30A8, ABCC8
36	fanconi-bickel syndrome	28.3	SLC2A2, ABCC8
37	liver cirrhosis	28.3	SLC2A4, IRS1, RETN, HNF4A
38	ischemia	28.1	IRS1, MAPK8IP1, ABCC8, SLC2A4, IRS2, RETN
39	carbohydrate metabolic disorder	28.0	IRS1, IRS2
40	hyperinsulinemic hypoglycemia	27.9	ABCC8, GCK, HNF4A
41	pancreatitis	27.6	IGF2BP2, HNF1B, WFS1, NEUROD1, SLC2A2, SLC2A4
42	morbid obesity	27.1	RETN, LIPC, IRS1, ABCC8, SLC2A4, SLC2A2
43	hyperinsulinism	25.9	GCK, LIPC, IRS1, IRS2, HNF1B, HNF4A
44	pancreatic cancer	25.7	CAPN10, HNF1B, SLC2A4, HNF4A, HNF1A, IRS1
45	adenoma	25.0	SLC2A2, GCK, IRS1, IRS2, NEUROD1, RETN
46	prostatitis	24.3	CDKAL1, RETN, HNF4A, IRS1, IRS2, NEUROD1
47	leucine-sensitive hypoglycemia of infancy	13.2	GCK, ABCC8
48	glomerulocystic kidney disease	13.2	HNF1A, GCK, HNF1B
49	polycystic kidney disease, autosomal recessive	13.0	HNF1B, HNF1A
50	persistent hyperinsulinemic hypoglycemia of infancy	12.8	GCK, ABCC8

Clinical features from OMIM: 125853

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 chromium picolinate

MGI Mouse Phenotypes related to diabetes mellitus, noninsulin-dependent:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	8.4	CDKAL1, WFS1, MAPK8IP1, NEUROD1, SLC30A8, ABCC8
2	adipose tissue phenotype	MP:0005375	7.9	GCGR, SLC2A4, HNF1A, CAPN10, IRS2, IRS1
3	liver/biliary system phenotype	MP:0005370	7.5	SLC2A4, RETN, IRS1, MAPK8IP1, HNF1A, HNF1B
4	growth/size phenotype	MP:0005378	6.9	HNF1B, IRS2, MAPK8IP1, IRS1, GCGR, HNF4A
5	mortality/aging	MP:0010768	6.7	HNF4A, GCK, GCGR, NEUROD1, IRS2, MAPK8IP1
6	homeostasis/metabolism phenotype	MP:0005376	4.3	CAPN10, HNF1A, HNF1B, HNF4A, ABCC8, SLC30A8

Genes related to diabetes mellitus, noninsulin-dependent according to GeneCards:

(show all 22)

id	Symbol	Description	Score	GeneCards Section Context
1	SLC30A8	solute carrier family 30 (zinc transporter), member 8	11.1	Summaries, UniProt Related
2	NIDDM4	Diabetes mellitus, noninsulin-dependent	11.1	Aliases & Descriptions
3	NIDDM2	non-insulin-dependent diabetes mellitus (common, type 2) 2	11.1
4	CAPN10	calpain 10	11.1
5	WFS1	Wolfram syndrome 1 (wolframin)	11.1
6	HNF1A	HNF1 homeobox A	11.1
7	GCK	glucokinase (hexokinase 4)	11.1
8	NIDDM3	Noninsulin-dependent diabetes mellitus 3	11.1
9	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	11.1
10	GCGR	glucagon receptor	11.1
11	NEUROD1	neuronal differentiation 1	11.1
12	RETN	resistin	11.1
13	IRS2	insulin receptor substrate 2	11.1
14	HNF1B	HNF1 homeobox B	11.1
15	SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	11.1
16	SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	11.1
17	LIPC	lipase, hepatic	11.1
18	HNF4A	hepatocyte nuclear factor 4, alpha	11.1
19	IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2	11.1
20	IRS1	insulin receptor substrate 1	11.1
21	ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	11.1
22	CDKAL1	CDK5 regulatory subunit associated protein 1-like 1	11.1

Pathways related to diabetes mellitus, noninsulin-dependent according to GeneDecks:

(show all 16)

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of HNF110	9.7	HNF1B, HNF1A, SLC2A2
2	Glucose transport38	9.7	SLC2A4, SLC2A2, GCK
3	Dichloroethylene metabolism41	9.5	HNF1A, HNF4A
4	MODY (Maturity-Onset Diabetes of Young)36	9.4	GCK, NEUROD1, SLC2A2, HNF4A
5	HIF1Alpha Pathway36	9.4	HNF4A, SLC2A4, SLC2A2
6	Regulation of lipid metabolism_Insulin signaling-generic cascades41	9.2	IRS1, SLC2A4, IRS2
7	Adipocytokine signaling pathway20	9.2	IRS1, IRS2, SLC2A4
8	Regulation of lipid metabolism Insulin signaling-generic cascades10	9.1	IRS1, IRS2, SLC2A4
9	Adipocytokines & Insulin Signaling37	9.1	IRS1, IRS2, SLC2A4, RETN
10	Insulin signaling pathway20	9.1	SLC2A4, IRS1, GCK, IRS2
11	Maturity onset diabetes of the young20	8.9	GCK, NEUROD1, SLC2A2, HNF4A, HNF1A, HNF1B
12	Development_Leptin signaling via PI3K-dependent pathway41	8.6	IRS1, SLC2A4, ABCC8, IRS2
13	Development Leptin signaling via PI3K-dependent pathway10	8.6	IRS1, ABCC8, IRS2, SLC2A4
14	Glucose / Energy Metabolism3	8.5	WFS1, SLC2A4, HNF4A, IRS2, NEUROD1, IRS1
15	Type II diabetes mellitus20	8.1	SLC2A4, IRS2, ABCC8, GCK, SLC2A2, IRS1
16	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics34	7.2	IRS2, HNF4A, HNF1B, HNF1A, SLC2A2, IRS1

Compounds related to diabetes mellitus, noninsulin-dependent according to GeneDecks:

(show all 49)

id	Compound	Score	Top Affiliating Genes
1	3-o-methylglucose32	10.5	SLC2A4
2	nnmt32	10.3	HNF1B, HNF1A
3	alloxan32	10.2	SLC2A2, GCK
4	threonine32	10.1	HNF4A, MAPK8IP1
5	preproinsulin32	10.1	GCK, SLC2A2
6	incretin32	10.1	SLC2A2, GCGR, GCK
7	glucose32	9.8	GCGR, MAPK8IP1, NEUROD1, SLC2A2
8	fructose32 9 9	11.7	GCGR, SLC2A4, SLC2A2, GCK
9	vanadium32	9.6	SLC2A4, IRS1
10	glucose 6-phosphate32 18	10.5	GCK, SLC2A4, SLC2A2
11	tolbutamide32 34 9 9	12.5	HNF1A, ABCC8, GCK
12	thiazolidinedione32	9.5	RETN, IRS1, SLC2A4
13	katp32	9.4	ABCC8, GCK, SLC2A2
14	glimepiride32 34 9 9	12.4	RETN, ABCC8, SLC2A4
15	glucosamine32 9 18 9	12.4	IRS1, SLC2A4, IRS2, GCK
16	streptozotocin32	9.3	SLC2A2, SLC2A4, GCK, IRS1
17	2-deoxyglucose32	9.3	GCK, SLC2A4, IRS1, SLC2A2
18	mg 13232 42	10.3	HNF4A, HNF1A, CAPN10, IRS1
19	pyruvate32	9.3	GCK, HNF4A, SLC2A2, SLC2A4, HNF1A
20	rosiglitazone32 9 18 9	12.2	SLC2A4, IRS2, IRS1, RETN
21	pioglitazone32 9 9	11.2	IRS1, SLC2A4, RETN, LIPC
22	glibenclamide32 34	10.1	ABCC8, LIPC, SLC2A4
23	anisomycin32 42 9 9	12.1	IRS1, IRS2, SLC2A4
24	ly29400232	9.0	GCK, RETN, IRS1, SLC2A4, IRS2
25	okadaic acid32 42	9.9	HNF4A, SLC2A4, IRS2, IRS1
26	phosphotyrosine32	8.9	IRS2, SLC2A4, IRS1, MAPK8IP1
27	glycerol32 9 18 9	11.8	SLC2A4, IRS1, GCK, HNF4A, LIPC
28	nitric oxide32 9 18 9	11.7	GCK, RETN, IRS2, MAPK8IP1, HNF4A, SLC2A4
29	oligonucleotide32	8.7	HNF1B, GCGR, IRS2, GCK, HNF1A, HNF4A
30	phosphoenolpyruvate32 9 9	10.7	GCK, HNF4A, SLC2A2, SLC2A4, HNF1A, IRS1
31	leucine32	8.5	MAPK8IP1, HNF4A, GCK, ABCC8, HNF1A, SLC2A2
32	potassium32 9 18 9	11.5	SLC2A2, ABCC8, HNF1A, GCK, CAPN10, IRS1
33	testosterone32 9 18 9	11.4	ABCC8, HNF4A, LIPC, IRS1
34	dexamethasone32 42 34 9 9	12.4	SLC2A4, HNF4A, HNF1A, IRS2, RETN, GCK
35	c-peptide32	8.4	LIPC, IRS1, HNF1A, HNF4A, SLC2A2, RETN
36	sulfonylurea32	8.3	SLC2A2, SLC2A4, IRS1, GCK, ABCC8, HNF1A
37	metformin32 34 9 9	11.3	RETN, GCK, IRS1, IRS2, SLC2A4, ABCC8
38	alanine32	8.3	IRS1, SLC2A4, HNF4A, IRS2, RETN, GCK
39	retinoic acid32 42 18	10.1	GCK, IRS2, HNF1A, HNF1B, SLC2A4, HNF4A
40	cholesterol32 9 18 9	11.0	HNF1A, GCK, LIPC, CAPN10, HNF1B, RETN
41	atp32	8.0	GCGR, LIPC, MAPK8IP1, ABCC8, SLC2A2, HNF4A
42	sterol32	7.7	SLC2A2, SLC2A4, HNF4A, HNF1A, GCK, RETN
43	arginine32	7.5	LIPC, SLC2A2, ABCC8, HNF4A, GCK, HNF1B
44	serine32	7.2	MAPK8IP1, IRS2, IRS1, LIPC, GCK, ABCC8
45	calcium32 9 18 9	10.2	GCGR, CAPN10, MAPK8IP1, WFS1, IRS2, LIPC
46	lipid32	7.0	HNF1A, RETN, SLC2A4, GCK, LIPC, IRS2
47	fatty acid32	7.0	HNF4A, GCGR, LIPC, IRS1, GCK, IRS2
48	tyrosine32	6.7	RETN, LIPC, IRS1, IRS2, HNF1A, HNF4A
49	glycogen32 18	7.6	GCK, CAPN10, RETN, GCGR, LIPC, IRS1

Biological processes related to diabetes mellitus, noninsulin-dependent according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of pronephros size	GO:035565	10.2	HNF1B, HNF1A
2	positive regulation of transcription initiation from RNA polymerase II promoter	GO:060261	10.1	HNF1A, HNF1B
3	glucose import	GO:046323	10.1	SLC2A4, HNF1A
4	positive regulation of insulin secretion	GO:032024	9.9	SLC30A8, GCK, IRS2, CAPN10
5	insulin secretion	GO:030073	9.8	HNF1A, SLC30A8, HNF1B, NEUROD1
6	lipid homeostasis	GO:055088	9.7	IRS2, HNF4A
7	hexose transport	GO:008645	9.7	SLC2A2, SLC2A4, GCK
8	positive regulation of glucose metabolic process	GO:010907	9.7	IRS1, IRS2
9	glucose transport	GO:015758	9.6	SLC2A4, GCK, SLC2A2
10	positive regulation of glucose import	GO:046326	9.6	IRS1, IRS2, CAPN10
11	positive regulation of glycogen biosynthetic process	GO:045725	9.6	GCK, IRS1, IRS2
12	positive regulation of fatty acid beta-oxidation	GO:032000	9.6	IRS1, IRS2
13	regulation of lipid metabolic process	GO:019216	9.4	IRS2, HNF4A
14	endocrine pancreas development	GO:031018	9.2	GCK, HNF4A, SLC2A2, HNF1B, NEUROD1
15	cellular response to insulin stimulus	GO:032869	9.1	IRS2, IRS1, GCK, SLC2A4, CAPN10
16	response to glucose stimulus	GO:009749	8.9	NEUROD1, HNF4A, SLC2A2, SLC30A8, IRS2, HNF1B
17	regulation of insulin secretion	GO:050796	8.7	SLC2A2, NEUROD1, GCK, HNF4A, ABCC8
18	transmembrane transport	GO:055085	8.4	SLC2A2, SLC2A4, SLC30A8, ABCC8, GCK
19	glucose homeostasis	GO:042593	8.3	HNF4A, SLC30A8, GCK, IRS1, HNF1A, SLC2A4

Molecular functions related to diabetes mellitus, noninsulin-dependent according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylinositol 3-kinase binding	GO:043548	9.6	IRS1, IRS2
2	D-glucose transmembrane transporter activity	GO:055056	9.5	SLC2A4, SLC2A2
3	insulin receptor binding	GO:005158	9.1	IRS1, IRS2, SLC2A2