MCID: DBT026
MIFTS: 39

Diabetes Mellitus, Noninsulin-Dependent malady

Summaries for Diabetes Mellitus, Noninsulin-Dependent

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47OMIM, 33MalaCards
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MalaCards: Diabetes Mellitus, Noninsulin-Dependent is related to diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension and diabetes mellitus, noninsulin-dependent, 2. An important gene associated with Diabetes Mellitus, Noninsulin-Dependent is SLC30A8 (solute carrier family 30 (zinc transporter), member 8), and among its related pathways are IRS activation and Facilitative Na+-independent glucose transporters. The compounds estrogen and [3h]2-deoxyglucose have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and skeletal muscle, and related mouse phenotypes are liver/biliary system and adipose tissue.

Description from OMIM:47 125853,135853

Aliases & Classifications for Diabetes Mellitus, Noninsulin-Dependent

Sources:
47OMIM
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Aliases & Descriptions:

diabetes mellitus, noninsulin-dependent 47


Related Diseases for Diabetes Mellitus, Noninsulin-Dependent

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Diabetes Mellitus, Noninsulin-Dependent family:

diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension diabetes mellitus, noninsulin-dependent 1
diabetes mellitus, noninsulin-dependent, late onset diabetes mellitus, noninsulin-dependent, 2

Diseases related to Diabetes Mellitus, Noninsulin-Dependent via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension10.6
2diabetes mellitus, noninsulin-dependent, 210.6
3diabetes mellitus, noninsulin-dependent 110.5
4diabetes mellitus, noninsulin-dependent, association with10.5
5diabetes mellitus, noninsulin-dependent, late onset10.5
6hypertension10.0RETN
7hepatitis10.0HNF4A
8hyperandrogenism10.0RETN, CAPN10
9essential hypertension10.0GCGR, RETN
10familial hyperinsulinism10.0ABCC8
11lipodystrophy10.0RETN
12maturity-onset diabetes of the young10.0NEUROD1, HNF1B, HNF4A
13polycystic ovary syndrome10.0IRS1, IRS2, CAPN10
14glucose intolerance10.0SLC2A4, RETN, IRS2, CAPN10
15ischemia10.0MAPK8IP1, ABCC8, SLC2A4
16hypertriglyceridemia10.0IRS1, LIPC, SLC2A4
17type 2 diabetes mellitus10.0HNF1B, IRS1, MAPK8IP1, SLC2A4
18adenoma10.0HMGA1, HNF4A
19hyperinsulinism10.0IRS2, IRS1, RETN, ABCC8
20pituitary adenoma10.0ABCC8, NEUROD1
21fatty liver disease10.0HNF4A, LIPC, RETN
22insulinoma10.0SLC2A2, ABCC8, HNF4A
23neonatal diabetes mellitus10.0SLC2A2, ABCC8, HNF1B
24type 1 diabetes10.0RETN, LIPC, NEUROD1, HNF4A
25ischemic heart disease10.0ABCC8, RETN, LIPC
26liver cirrhosis10.0IRS1, RETN, SLC2A4
27primary hyperoxaluria10.0HNF4A, HNF1B, CAPN10, LIPC, RETN
28metabolic syndrome x10.0HNF4A, CAPN10, RETN, ABCC8, SLC2A2
29galactosemia10.0HNF4A, HNF1B, IRS1, LIPC, RETN
30hypercholesterolemia10.0HMGA1, RETN, LIPC, CAPN10
31atherosclerosis10.0HNF4A, CAPN10, IRS2, IRS1, LIPC, RETN
32hypoglycemia10.0SLC2A2, SLC2A4, ABCC8, HNF4A, GCGR
33gestational diabetes10.0HNF4A, CAPN10, IRS2, IRS1, RETN, ABCC8
34coronary heart disease10.0IRS1, LIPC, RETN, HMGA1
35adenocarcinoma10.0HNF4A, HNF1B, NEUROD1, HMGA1, SLC2A4
36pancreatic cancer10.0HNF4A, IRS2, IRS1, HMGA1, SLC2A4
37prostate cancer10.0HNF4A, HNF1B, IRS2, IRS1, MAPK8IP1, HMGA1
38obesity10.0GCGR, HNF4A, CAPN10, IRS2, IRS1, LIPC
39hepatocellular carcinoma10.0HNF4A, HNF1B, IRS1, LIPC, HMGA1, SLC2A2
40hyperglycemia9.9GCGR, HNF4A, HNF1B, IRS2, IRS1, NEUROD1
41insulin resistance9.9SLC2A4, HMGA1, ABCC8, RETN, GCGR, LIPC
42diabetes mellitus9.9GCGR, HNF4A, HNF1B, CAPN10, IRS2, IRS1

Graphical network of the top 20 diseases related to Diabetes Mellitus, Noninsulin-Dependent:



Diseases related to diabetes mellitus, noninsulin-dependent

Clinical Features for Diabetes Mellitus, Noninsulin-Dependent

Sources:
47OMIM
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Clinical features from OMIM:

125853,135853

Drugs & Therapeutics for Diabetes Mellitus, Noninsulin-Dependent

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Diabetes Mellitus, Noninsulin-Dependent

Drug clinical trials:

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Search NIH Clinical Center for Diabetes Mellitus, Noninsulin-Dependent

Search CenterWatch for Diabetes Mellitus, Noninsulin-Dependent

Genetic Tests for Diabetes Mellitus, Noninsulin-Dependent

Anatomical Context for Diabetes Mellitus, Noninsulin-Dependent

Sources:
33MalaCards
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MalaCards organs/tissues related to Diabetes Mellitus, Noninsulin-Dependent:

33
Liver, Heart, Skeletal muscle, Adipocyte, Monocytes, B cells, Pancreatic islet

Animal Models for Diabetes Mellitus, Noninsulin-Dependent or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Diabetes Mellitus, Noninsulin-Dependent

Sources:
51PubMed
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Articles related to Diabetes Mellitus, Noninsulin-Dependent:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Salivary lysosomal exoglycosidases profiles in patients with insulin-dependent and noninsulin-dependent diabetes mellitus. (24285450)
2013
2
Inappropriately low erythropoietin response for the degree of anemia in patients with noninsulin-dependent diabetes mellitus. (16132904)
2006
3
Plasma homocysteine levels in noninsulin-dependent diabetes mellitus with retinopathy and neovascular glaucoma. (16200446)
2004
4
Insulin resistance associated with leptin deficiency in mice: a possible model for noninsulin-dependent diabetes mellitus. (11444594)
2001
5
Glibenclamide vs gliclazide in reducing oxidative stress in patients of noninsulin dependent diabetes mellitus--a double blind randomized study. (11837468)
2001
6
Evaluation of pancreatic exocrine function using pure pancreatic juice in noninsulin-dependent diabetes mellitus. (10914777)
2000
7
Treatment of nonproliferative diabetic retinopathy with Defibrotide in noninsulin-dependent diabetes mellitus: a pilot study. (10406153)
1999
8
Novel allele of the insulin receptor substrate-1 bearing two non- conservative amino acid substitutions in a patient with noninsulin- dependent diabetes mellitus. (10206679)
1998
9
Molecular screening of uncoupling protein 2 gene in patients with noninsulin-dependent diabetes mellitus or obesity. (9709950)
1998
10
Insulin receptor substrate-1 and glucose transporter gene polymorphisms in noninsulin-dependent diabetes mellitus]. (11038788)
1998
11
Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus. (9398740)
1997
12
Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus. (9329371)
1997
13
Spontaneous hypoglycaemia in a noninsulin-dependent diabetes mellitus patient with disseminated pancreatic carcinoma. (9113488)
1997
14
Acipimox attenuates hypertriglyceridemia in dyslipidemic noninsulin dependent diabetes mellitus patients without perturbation of insulin sensitivity and glycemic control. (9229195)
1997
15
Paraoxonase polymorphism (Gln192-Arg) is associated with coronary heart disease in Japanese noninsulin-dependent diabetes mellitus. (9215303)
1997
16
Effect of sulfonylurea withdrawal on proinsulin levels, B cell function, and glucose disposal in subjects with noninsulin-dependent diabetes mellitus. (8784086)
1996
17
Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. (8855830)
1996
18
Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus. (18406764)
1996
19
Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus. (8636258)
1996
20
Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects. (8981937)
1996
21
Deletion of Gly723 in the insulin receptor substrate-1 of a patient with noninsulin-dependent diabetes mellitus. (8723689)
1996
22
A novel (TA)n polymorphism in the hexokinase II gene: application to noninsulin-dependent diabetes mellitus in the Pima Indians. (8834247)
1996
23
Role of lipids in development of noninsulin-dependent diabetes mellitus: lessons learned from Pima Indians. (8729131)
1996
24
Nonenzymic glycation of apolipoprotein B in patients with insulin- and noninsulin-dependent diabetes mellitus. (8595706)
1995
25
Choice of treatment affects plasma levels of insulin-like growth factor-binding protein-1 in noninsulin-dependent diabetes mellitus. (7536208)
1995
26
Analysis of the insulin receptor gene in noninsulin-dependent diabetes mellitus by denaturing gradient gel blots: a clinical research center study. (7775636)
1995
27
Myocardial glucose metabolism in noninsulin-dependent diabetes mellitus patients evaluated by FDG-PET. (7884509)
1995
28
Amino acid polymorphisms of the insulin receptor substrate-1 in Japanese noninsulin-dependent diabetes mellitus. (7673430)
1995
29
Pancreatic islet amyloid formation in patients with noninsulin-dependent diabetes mellitus. Implication for therapeutic strategy. (7594773)
1995
30
Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese-American men: impact of obesity--clinical research center study. (7714116)
1995
31
The population association of glucokinase gene with type 2 (noninsulin-dependent) diabetes mellitus in Chinese. (7712840)
1995
32
High retinol/retinol-binding protein ratio in noninsulin-dependent diabetes mellitus. (7485220)
1995
33
Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity. (8106637)
1994
34
Fasting affects serum insulin-like growth factors (IGFs) and IGF-binding proteins differently in patients with noninsulin-dependent diabetes mellitus versus healthy nonobese and obese subjects. (7512573)
1994
35
Molecular screening of the lipoprotein lipase gene in hypertriglyceridemic members of familial noninsulin-dependent diabetes mellitus families. (7962342)
1994
36
Characterization of insulin-like growth factor-binding proteins produced by cultured fibroblasts from patients with noninsulin-dependent diabetes mellitus, insulin-dependent diabetes mellitus, or obesity. (7527414)
1994
37
Analysis of the glucokinase gene promoter in Japanese subjects with noninsulin-dependent diabetes mellitus. (8077376)
1994
38
Pronounced blood glucose-lowering effect of the antilipolytic drug acipimox in noninsulin-dependent diabetes mellitus patients during a 3-day intensified treatment period. (8126147)
1994
39
Effect of insulin therapy on the progression of retinopathy in noninsulin-dependent diabetes mellitus. (8116766)
1994
40
Accelerated cholesteryl ester transfer in noninsulin-dependent diabetes mellitus. (8141851)
1993
41
Relative expression of insulin receptor isoforms does not differ in lean, obese, and noninsulin-dependent diabetes mellitus subjects. (7684396)
1993
42
Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in men. (8325960)
1993
43
Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia. (8432795)
1993
44
Understanding and treating dyslipidemia associated with noninsulin-dependent diabetes mellitus and hypertension. (8361860)
1993
45
Effect of insulin therapy on progression of retinopathy in noninsulin-dependent diabetes mellitus. (8213993)
1993
46
Effect of insulin therapy on progression of retinopathy in noninsulin-dependent diabetes mellitus. (8488908)
1993
47
Glomerular function in Pima Indians with noninsulin-dependent diabetes mellitus of recent onset. (1864963)
1991
48
The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. (1986032)
1991
49
Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus. (2123890)
1990
50
Polymorphism in the 5' flanking region of the human insulin gene. Relationships with noninsulin-dependent diabetes mellitus, glucose and insulin concentrations, and diabetes treatment in the Pima Indians. (6392341)
1984

Genetic Variations for Diabetes Mellitus, Noninsulin-Dependent

Expression for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

Search GEO for disease gene expression data for Diabetes Mellitus, Noninsulin-Dependent.

Pathways for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

Sources:
54Reactome, 30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 4Cell Signaling Technology, 50PharmGKB
See all sources

Pathways related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1IRS1, IRS2
210.0SLC2A2, SLC2A4
39.9SLC2A4, IRS1, IRS2
4
Hide members
9.8SLC2A2, ABCC8, GCGR
59.8HNF4A, SLC2A4, SLC2A2
69.8SLC2A2, ABCC8, HNF4A
79.8HMGA1, IRS1, IRS2
89.8IRS2, IRS1, HMGA1
9
Hide members
9.7HMGA1, SLC2A4, SLC2A2
10
Hide members
9.7IRS2, IRS1, RETN, SLC2A4
11
Development Leptin signaling via PI3K-dependent pathway
Hide members
9.6SLC2A4, ABCC8, IRS1, IRS2
12
Hide members
9.6SLC2A2, NEUROD1, HNF1B, HNF4A
139.5HNF4A, IRS2, IRS1, NEUROD1, SLC2A4
149.4IRS2, IRS1, RETN, HMGA1, SLC2A4
15
Hide members
8.8SLC2A2, HNF4A, HNF1B, IRS2, IRS1, NEUROD1

Compounds for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
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Compounds related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5LIPC
2[3h]2-deoxyglucose2910.4SLC2A2, SLC2A4
3vanadium4510.4SLC2A4, IRS1
43-o-methylglucose4510.3SLC2A2, SLC2A4
5repaglinide45 50 1112.3ABCC8, NEUROD1
6incretin4510.3SLC2A2, GCGR
7glimepiride45 50 1112.3SLC2A4, ABCC8, RETN
82,4-dinitrophenol4510.3SLC2A4, IRS1
9thiazolidinedione4510.3SLC2A4, RETN, IRS1
10glucosamine45 11 2412.2IRS2, IRS1, SLC2A4
11fructose45 1111.2GCGR, SLC2A4, SLC2A2
12glibenclamide45 29 50 6013.2SLC2A4, ABCC8, LIPC
13anisomycin45 1111.2IRS2, IRS1, SLC2A4
14streptozotocin4510.1IRS1, SLC2A4, SLC2A2
152-deoxyglucose45 1111.1SLC2A2, SLC2A4, IRS1
16rosiglitazone45 50 29 11 2414.1IRS2, IRS1, RETN, SLC2A4
17gliclazide45 50 1112.1SLC2A4, ABCC8
18pioglitazone45 50 29 1113.0IRS1, LIPC, RETN, SLC2A4
19phosphotyrosine4510.0IRS2, IRS1, MAPK8IP1, SLC2A4
20palmitate4510.0SLC2A4, IRS1, HNF4A
21okadaic acid45 6011.0HNF4A, IRS2, IRS1, SLC2A4
22phosphoenolpyruvate45 1111.0HNF4A, IRS1, SLC2A4, SLC2A2
23sulfonylurea4510.0IRS1, ABCC8, SLC2A4, SLC2A2
24lovastatin45 50 60 29 1114.0IRS1, LIPC, HMGA1
25glycerol45 11 2412.0SLC2A4, LIPC, IRS1, HNF4A
26metformin45 50 1111.9IRS2, IRS1, RETN, ABCC8, SLC2A4
27p002459.9HNF4A, LIPC, RETN
28atorvastatin45 50 29 11 2413.9LIPC, RETN, HMGA1
29pd 98,059459.9HNF4A, IRS2, IRS1, SLC2A4
30rapamycin459.8IRS2, IRS1, HMGA1, SLC2A4
31ly294002459.8IRS2, IRS1, RETN, HMGA1, SLC2A4
32c-peptide459.7HNF4A, IRS1, LIPC, RETN, SLC2A2
33dexamethasone45 50 29 1112.6SLC2A4, RETN, IRS1, HNF4A
34testosterone45 60 11 2412.6HNF4A, IRS1, LIPC, RETN, ABCC8, SLC2A4
35phosphatidylinositol-3,4,5-trisphosphate45 2410.6SLC2A4, IRS1, IRS2
36oligonucleotide459.6SLC2A2, IRS2, HNF1B, HNF4A, GCGR
37atp45 2910.5SLC2A2, ABCC8, MAPK8IP1, LIPC, HNF4A, GCGR
38retinoic acid45 2410.4HNF4A, HNF1B, IRS2, IRS1, NEUROD1, HMGA1
39threonine459.3HNF4A, IRS2, IRS1, LIPC, MAPK8IP1, HMGA1
40potassium45 11 2411.2CAPN10, IRS1, ABCC8, SLC2A2
41cholesterol45 29 11 2412.1HNF4A, HNF1B, CAPN10, LIPC, RETN, ABCC8
42serine459.1HNF4A, IRS2, IRS1, LIPC, MAPK8IP1, ABCC8
43sterol459.1HNF4A, IRS2, IRS1, LIPC, RETN, HMGA1
44tyrosine459.0HNF4A, IRS2, IRS1, LIPC, RETN, ABCC8
45fatty acid459.0GCGR, HNF4A, IRS2, IRS1, LIPC, RETN
46arginine458.8HNF4A, HNF1B, CAPN10, IRS1, LIPC, ABCC8
47calcium45 50 11 2411.6GCGR, HNF4A, CAPN10, IRS2, NEUROD1, LIPC
48glycogen45 249.6GCGR, HNF4A, CAPN10, IRS2, IRS1, LIPC
49lipid458.4HNF4A, CAPN10, IRS2, IRS1, LIPC, LIPH
50glucose457.7SLC2A2, GCGR, HNF4A, HNF1B, CAPN10, IRS2

GO Terms for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

Sources:
16Gene Ontology
See all sources

Biological processes related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glucose metabolic processGO:01090710.3IRS1, IRS2
2positive regulation of fatty acid beta-oxidationGO:03200010.2IRS1, IRS2
3insulin secretionGO:03007310.2SLC30A8, NEUROD1, HNF1B
4positive regulation of glycogen biosynthetic processGO:04572510.2IRS1, IRS2
5lipid homeostasisGO:05508810.2HNF4A, IRS2
6signal transduction involved in regulation of gene expressionGO:02301910.1HNF4A, NEUROD1
7mammary gland developmentGO:03087910.1IRS1, IRS2
8regulation of lipid metabolic processGO:01921610.0HNF4A, IRS2
9energy reserve metabolic processGO:00611210.0GCGR, ABCC8, SLC2A2
10positive regulation of insulin secretionGO:03202410.0CAPN10, IRS2, SLC30A8
11positive regulation of glucose importGO:0463269.9CAPN10, IRS2, IRS1
12endocrine pancreas developmentGO:0310189.9HNF4A, HNF1B, NEUROD1, SLC2A2
13response to glucose stimulusGO:0097499.9HNF4A, HNF1B, IRS2, NEUROD1, SLC30A8
14regulation of insulin secretionGO:0507969.9SLC2A2, ABCC8, NEUROD1, HNF4A
15cellular response to insulin stimulusGO:0328699.7CAPN10, IRS2, IRS1, SLC2A4
16triglyceride homeostasisGO:0703289.7LIPC, HNF4A
17glucose homeostasisGO:0425939.7SLC30A8, SLC2A4, NEUROD1, IRS1, HNF4A, GCGR

Molecular functions related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol 3-kinase bindingGO:04354810.1IRS1, IRS2
2D-glucose transmembrane transporter activityGO:0550569.9SLC2A2, SLC2A4
3phospholipase activityGO:0046209.6LIPH, LIPC

Products for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Sources for Diabetes Mellitus, Noninsulin-Dependent

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet