MCID: DBT026
MIFTS: 84

Diabetes Mellitus, Noninsulin-Dependent malady

Genetic diseases (common), Endocrine diseases categories

Summaries for Diabetes Mellitus, Noninsulin-Dependent

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MedlinePlus:34 Diabetes means your blood glucose, or blood sugar, levels are too high. with type 2 diabetes, the more common type, your body does not make or use insulin well. insulin is a hormone that helps glucose get into your cells to give them energy. without insulin, too much glucose stays in your blood. over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth. you have a higher risk of type 2 diabetes if you are older, obese, have a family history of diabetes, or do not exercise. having prediabetes also increases your risk. prediabetes means that your blood sugar is higher than normal but not high enough to be called diabetes. the symptoms of type 2 diabetes appear slowly. some people do not notice symptoms at all. the symptoms can include being very thirsty urinating often feeling very hungry or tired losing weight without trying having sores that heal slowly having blurry eyesight a blood test can show if you have diabetes. many people can manage their diabetes through healthy eating, physical activity, and blood glucose testing. some people also need to take diabetes medicines. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Diabetes Mellitus, Noninsulin-Dependent, also known as type 2 diabetes mellitus, is related to polycystic ovary syndrome and fatty liver disease, and has symptoms including autosomal dominant inheritance, insulin resistance and late onset. An important gene associated with Diabetes Mellitus, Noninsulin-Dependent is SLC30A8 (solute carrier family 30 (zinc transporter), member 8), and among its related pathways are IGF1 pathway and Growth hormone receptor signaling. The drugs insulin and insulin, aspart, human and the compounds "sulfonamides, urea derivatives" and alloxan have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and kidney, and related mouse phenotypes are pigmentation and liver/biliary system.

Disease Ontology:10 A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.

Description from OMIM:47 125853

Aliases & Classifications for Diabetes Mellitus, Noninsulin-Dependent

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Diabetes Mellitus, Noninsulin-Dependent, Aliases & Descriptions:

Name: Diabetes Mellitus, Noninsulin-Dependent 47 11 32
Type 2 Diabetes Mellitus 32 10 12
Type Ii Diabetes Mellitus 10 24
Insulin Resistance 47 45
Niddm 10 45
Diabetes Mellitus, Noninsulin-Dependent, Association with 47
Diabetes Mellitus, Noninsulin-Dependent, Late Onset 47
Diabetes Mellitus, Type 2, Susceptiblity to 47
 
Diabetes Mellitus, Noninsulin-Dependent, 2 47
Diabetes Mellitus, Non-Insulin-Dependent 47
Hypertension, Insulin Resistance-Related 47
Non-Insulin-Dependent Diabetes Mellitus 10
Diabetes Mellitus, Type Ii 47
Diabetes Mellitus, Type 2 47
Diabetes, Type 2 47
Diabetes Type 2 34


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Endocrine diseases


External Ids:

OMIM47 125853
Disease Ontology10 DOID:9352
MeSH35 D003924
NCIt40 C26747

Related Diseases for Diabetes Mellitus, Noninsulin-Dependent

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Diseases in the Diabetes Mellitus, Noninsulin-Dependent family:

Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Noninsulin-Dependent, 5
Diabetes Mellitus, Noninsulin-Dependent 1 Kcnj11-Related Susceptibility to Noninsulin-Dependent Diabetes Mellitus

Diseases related to Diabetes Mellitus, Noninsulin-Dependent via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 452)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome31.8PPARG, LIPC, IRS2, RETN
2fatty liver disease31.5RETN, LIPC, PPARG
3glucose intolerance31.4PPARG, IRS2, RETN, GCK, ENPP1
4hyperglycemia31.2SLC2A2, ENPP1, GCK, GCGR, HNF1A, RETN
5maturity-onset diabetes of the young31.0GCK, HNF1A, KCNJ11
6hyperinsulinism30.8PPARG, KCNJ11, IRS2, RETN, GCK
7vascular disease30.8RETN, LIPC, PPARG
8uremia30.8ENPP1, RETN, LIPC
9breast cancer30.7PPARG, PTPN1, IRS2, TCF7L2, HNF1A, HMGA1
10metabolic syndrome x30.7SLC2A2, GCK, RETN, PTPN1, PPARG
11diabetes mellitus, insulin-dependent30.6GCK, HNF1A
12mody, type ii30.5ENPP1, GCK, HNF1A, RETN, TCF7L2, IRS2
13insulinoma30.5KCNJ11, WFS1, HNF1A, GCK, SLC2A2
14adenoma30.5HMGA1, HNF1A, TCF7L2, PPARG
15diabetes mellitus, permanent neonatal30.4GCK, KCNJ11
16hyperinsulinemic hypoglycemia30.4KCNJ11, GCK
17colorectal cancer30.3PPARG, IRS2, TCF7L2, TCF4, HNF1A
18hypoglycemia30.3KCNJ11, GCGR, GCK, SLC2A2
19obesity30.3IRS2, LIPC, PTPN1, KCNJ11, PPARG, RETN
20lipid metabolism disorder30.2PPARG, PTPN1, LIPC, TCF7L2, RETN
21coronary artery disease30.1HMGA1, RETN, LIPC
22atherosclerosis30.0PPARG, PTPN1, LIPC, IRS2, TCF7L2, RETN
23hepatocellular carcinoma30.0SLC2A2, HMGA1, HNF1A, TCF4, TCF7L2, LIPC
24hepatitis11.1
25liver disease11.0
26hyperandrogenism10.9
27hepatitis c10.9
28lipodystrophy10.9
29peripheral neuropathy10.8
30hypertriglyceridemia10.7
31hepatitis c virus10.7
32diabetes mellitus, noninsulin-dependent, 210.7
33diabetes mellitus, noninsulin-dependent 110.7
34insulin-like growth factor i10.7
35morbid obesity10.6
36nonalcoholic steatohepatitis10.6
37tuberculosis10.6
38diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension10.6
39arthritis10.6
40peripheral vascular disease10.6
41dementia10.6
42acromegaly10.6
43rheumatoid arthritis10.6
44thyroiditis10.6
45rabson-mendenhall syndrome10.5
46diabetes mellitus, noninsulin-dependent, 510.5
47ovarian disease10.5
48renal cysts and diabetes syndrome10.5
49myocardial infarction10.5
50hypothyroidism10.5

Graphical network of the top 20 diseases related to Diabetes Mellitus, Noninsulin-Dependent:



Diseases related to diabetes mellitus, noninsulin-dependent

Symptoms for Diabetes Mellitus, Noninsulin-Dependent

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Symptoms by clinical synopsis from OMIM:

125853

Clinical features from OMIM:

125853

HPO human phenotypes related to Diabetes Mellitus, Noninsulin-Dependent:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 insulin resistance HP:0000855
3 late onset HP:0003584
4 type ii diabetes mellitus HP:0005978

Drugs & Therapeutics for Diabetes Mellitus, Noninsulin-Dependent

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Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus, Noninsulin-Dependent

Search NIH Clinical Center for Diabetes Mellitus, Noninsulin-Dependent

Inferred drug relations via UMLS62/NDF-RT41:

Show with subtypes

Cell-based therapeutics:


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Genetic Tests for Diabetes Mellitus, Noninsulin-Dependent

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Genetic tests related to Diabetes Mellitus, Noninsulin-Dependent:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 224

Anatomical Context for Diabetes Mellitus, Noninsulin-Dependent

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MalaCards organs/tissues related to Diabetes Mellitus, Noninsulin-Dependent:

33
Eye, Heart, Kidney, Testes, Bone, T cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetes Mellitus, Noninsulin-Dependent:
id TissueAnatomical CompartmentCell Relevance
1 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Diabetes Mellitus, Noninsulin-Dependent or affiliated genes

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MGI Mouse Phenotypes related to Diabetes Mellitus, Noninsulin-Dependent:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.7SLC30A8, IRS2, LIPH, KCNJ11
2MP:00053709.0PPARG, TCF7L2, RETN, HNF1A, GCK, ENPP1
3MP:00107718.9PPARG, KCNJ11, LIPH, IRS2, TCF7L2, WFS1
4MP:00053758.8PPARG, KCNJ11, PTPN1, IRS2, TCF7L2, RETN
5MP:00053698.6PPARG, KCNJ11, IRS2, TCF7L2, HNF1A, ENPP1
6MP:00053868.3PPARG, KCNJ11, PTPN1, IRS2, TCF7L2, WFS1
7MP:00107688.1TCF7L2, IRS2, PTPN1, KCNJ11, PPARG, TCF4
8MP:00053798.1SLC30A8, PPARG, KCNJ11, PTPN1, LIPC, IRS2
9MP:00053787.9TCF4, TCF7L2, IRS2, PTPN1, KCNJ11, PPARG
10MP:00053767.8RETN, TCF7L2, IRS2, LIPC, PTPN1, KCNJ11

Publications for Diabetes Mellitus, Noninsulin-Dependent

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Variations for Diabetes Mellitus, Noninsulin-Dependent

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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent:

64 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent:

7 (show all 32)
id Gene Variation Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
3ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
4PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
5AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
6SLC30A8NM_173851.2(SLC30A8): c.412C> T (p.Arg138Ter)single nucleotide variantprotectivers200185429GRCh37Chr 8, 118165323: 118165323
7SLC30A8NM_173851.2(SLC30A8): c.101_107delAAGATCA (p.Lys34Serfs)deletionprotectiveGRCh37Chr 8, 118159222: 118159228
8LIPCLIPC, -250G-Asingle nucleotide variantrisk factor
9INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
10INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenic, Pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
11IL6IL6, -174G-Csingle nucleotide variantrisk factor
12GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
13SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
14GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
15IGF2BP2NM_006548.4(IGF2BP2): c.239+29254C> Asingle nucleotide variantrisk factorrs4402960GRCh37Chr 3, 185511687: 185511687
16IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
17IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
18HMGA1HMGA1, 1-BP INS, IVS5, -13insertionrisk factor
19RETNRETN, +62G-Asingle nucleotide variantrisk factor
20CAPN10NM_023083.3(CAPN10): c.471-176G> Asingle nucleotide variantrisk factorrs3792267GRCh37Chr 2, 241531174: 241531174
21CAPN10CAPN10, IVS6, INS/DEL, 39-BPindelrisk factor
22CAPN10CAPN10, IVS13, g.16378G-Tsingle nucleotide variantrisk factor
23CAPN10CAPN10, IVS3, g.4841T-Csingle nucleotide variantrisk factor
24MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
25TCF7L2NM_030756.4(TCF7L2): c.382-41435C> Tsingle nucleotide variantrisk factorrs7903146GRCh37Chr 10, 114758349: 114758349
26TCF7L2NM_030756.4(TCF7L2): c.483+9017G> Tsingle nucleotide variantrisk factorrs12255372GRCh37Chr 10, 114808902: 114808902
27TCF7L2NM_030756.4(TCF7L2): c.483+7162G> Csingle nucleotide variantrisk factorrs11196205GRCh37Chr 10, 114807047: 114807047
28NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
29KCNJ11NM_000525.3(KCNJ11): c.67A> G (p.Lys23Glu)single nucleotide variantdrug response, risk factorrs5219GRCh37Chr 11, 17409572: 17409572
30ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
31ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
32HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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LifeMap Discovery
Genes differentially expressed in tissues of Diabetes Mellitus, Noninsulin-Dependent patients vs. healthy controls: 32 (show all 51)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1E2F8E2F transcription factor 8Blood+3.490.000
2KDM5Dlysine (K)-specific demethylase 5DBlood+3.490.028
3RPS4Y1ribosomal protein S4, Y-linked 1Blood+3.480.048
4CCNB1cyclin B1Blood+3.450.000
5SEC61A1Sec61 alpha 1 subunit (S. cerevisiae)Blood+3.420.000
6E2F7E2F transcription factor 7Blood+3.410.000
7HJURPHolliday junction recognition proteinBlood+3.400.000
8IGLV1-44immunoglobulin lambda variable 1-44Blood+3.380.000
9NCOA3nuclear receptor coactivator 3Blood+3.370.000
10KIF18Bkinesin family member 18BBlood+3.360.000
11ELL2elongation factor, RNA polymerase II, 2Blood+3.360.000
12SLC16A14solute carrier family 16, member 14Blood+3.350.001
13KIF20Akinesin family member 20ABlood+3.320.000
14TPX2TPX2, microtubule-associatedBlood+3.320.000
15ITM2Cintegral membrane protein 2CBlood+3.310.000
16UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)Blood+3.310.000
17TRIP13thyroid hormone receptor interactor 13Blood+3.300.000
18KIF15kinesin family member 15Blood+3.280.000
19AURKBaurora kinase BBlood+3.270.000
20KIF4Akinesin family member 4ABlood+3.260.000
21GTSE1G-2 and S-phase expressed 1Blood+3.260.000
22CDCA5cell division cycle associated 5Blood+3.250.000
23ESPL1extra spindle pole bodies homolog 1 (S. cerevisiae)Blood+3.240.000
24GINS1GINS complex subunit 1 (Psf1 homolog)Blood+3.230.000
25ANLNanillin, actin binding proteinBlood+3.230.000
26PKHD1L1polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1Blood+3.210.000
27RAD51AP1RAD51 associated protein 1Blood+3.200.000
28KLHL14kelch-like family member 14Blood+3.190.000
29CCND2cyclin D2Blood+3.170.000
30MANEAmannosidase, endo-alphaBlood+3.170.000
31ALDH1L2aldehyde dehydrogenase 1 family, member L2Blood+3.160.000
32SEC24ASEC24 family member ABlood+3.160.000
33FOXM1forkhead box M1Blood+3.150.000
34IGKV1D-13immunoglobulin kappa variable 1D-13Blood+3.150.000
35RAD51RAD51 recombinaseBlood+3.140.000
36IGLV4-60immunoglobulin lambda variable 4-60Blood+3.140.000
37OIP5Opa interacting protein 5Blood+3.130.000
38IGF1insulin-like growth factor 1 (somatomedin C)Blood+3.130.000
39DERL3derlin 3Blood+3.120.000
40DENND5BDENN/MADD domain containing 5BBlood+3.110.001
41MCM4minichromosome maintenance complex component 4Blood+3.100.000
42LAMC1laminin, gamma 1 (formerly LAMB2)Blood+3.090.000
43KCTD14potassium channel tetramerization domain containing 14Blood+3.090.000
44NUSAP1nucleolar and spindle associated protein 1Blood+3.080.000
45KIF14kinesin family member 14Blood+3.080.000
46C19orf10chromosome 19 open reading frame 10Blood+3.080.000
47SEL1L3sel-1 suppressor of lin-12-like 3 (C. elegans)Blood+3.020.000
48IGLV6-57immunoglobulin lambda variable 6-57Blood+3.010.000
49DEPDC1DEP domain containing 1Blood+3.010.000
50IGLV3-19immunoglobulin lambda variable 3-19Blood+2.970.001
51CENPFcentromere protein F, 350/400kDaBlood+2.970.000


Search GEO for disease gene expression data for Diabetes Mellitus, Noninsulin-Dependent.

Pathways for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Pathways related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0PTPN1, IRS2
210.0IRS2, PTPN1
310.0PPARG, TCF7L2
410.0SLC2A2, RETN
59.9PTPN1, IRS2, ENPP1
6
Show member pathways
9.9SLC2A2, HMGA1, GCK
7
Show member pathways
9.9HNF1A, GCK, SLC2A2
89.8KCNJ11, PTPN1, IRS2
9
Show member pathways
9.7KCNJ11, GCK, SLC2A2
10
Show member pathways
9.7KCNJ11, SLC2A2, GCGR
119.6GCK, KCNJ11, SLC2A2, HNF1A
12
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.6IRS2, PTPN1, PPARG, GCK
13
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.6SLC2A2, GCK, PTPN1, IRS2
149.5RETN, HMGA1, HNF1A, PPARG, IRS2
15
Show member pathways
9.4HNF1A, SLC2A2, IRS2, KCNJ11, GCK
16
Show member pathways
9.4SLC2A2, PPARG, GCK, TCF4, HNF1A
179.3WFS1, HNF1A, ENPP1, PPARG, PTPN1, IRS2
18
Show member pathways
9.0LIPC, PPARG, GCK, ENPP1, GCGR, SLC2A2

Compounds for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Compounds related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1sulfonamides, urea derivatives5110.4KCNJ11, TCF7L2
2alloxan4510.4GCK, SLC2A2
3Alpha-D-Glucose2610.4GCK, ENPP1
4tolbutamide45 30 51 1313.3KCNJ11, HNF1A, GCK
53-o-methylglucose4510.3SLC2A2, GCK
6incretin4510.3GCGR, GCK, SLC2A2
7preproinsulin4510.3GCK, SLC2A2
8mononucleotide4510.3TCF7L2, TCF4
9proglucagon4510.2TCF7L2, GCK, SLC2A2
10phosphoenolpyruvate45 1311.2GCK, HNF1A, SLC2A2
11glimepiride45 51 1312.1PPARG, RETN, KCNJ11
12katp4510.1KCNJ11, SLC2A2, GCK
13fenofibrate45 51 1312.1LIPC, PPARG, RETN
14fructose45 1311.1GCK, PTPN1, GCGR, SLC2A2
15atorvastatin45 51 30 26 1314.0HMGA1, PPARG, LIPC, RETN
16sulfonylurea4510.0GCK, HNF1A, KCNJ11, SLC2A2
17repaglinide51 45 1312.0PPARG, SLC30A8, TCF7L2, KCNJ11
182-deoxyglucose45 1311.0PPARG, GCK, SLC2A2
19rapamycin4510.0PPARG, IRS2, HMGA1, ENPP1
20pyruvate4510.0SLC2A2, GCK, PTPN1, HNF1A
21rosiglitazone30 45 51 26 1314.0PPARG, RETN, PTPN1, IRS2
22pioglitazone30 45 51 1313.0PPARG, PTPN1, LIPC, RETN
23thyroxine45 2610.9RETN, LIPC, PPARG
24potassium45 26 1311.8HNF1A, KCNJ11, GCK, SLC2A2
25threonine459.8LIPC, IRS2, PTPN1, HMGA1, GCK, ENPP1
26dexamethasone45 51 30 1312.8HNF1A, PPARG, GCK, IRS2, RETN, ENPP1
27phosphatidylinositol459.8IRS2, ENPP1, RETN, TCF7L2, PTPN1
28ly294002459.8GCK, HMGA1, RETN, TCF7L2, IRS2, PPARG
29nitric oxide45 26 1311.8GCK, PTPN1, RETN, IRS2, TCF7L2
30oligonucleotide459.7GCGR, PTPN1, IRS2, HNF1A, SLC2A2, GCK
31glutamine459.7ENPP1, HNF1A, PTPN1, KCNJ11, GCK, PPARG
32c-peptide459.7LIPC, SLC2A2, GCK, KCNJ11, HNF1A, RETN
33testosterone45 61 26 1312.7PPARG, TCF7L2, PTPN1, RETN, LIPC
34alanine459.6PPARG, PTPN1, IRS2, RETN, GCK
35cholesterol45 30 26 1312.6GCK, HMGA1, HNF1A, RETN, LIPC, PPARG
36tyrosine459.6LIPC, RETN, HMGA1, PTPN1, ENPP1, HNF1A
37oxygen45 2610.6IRS2, LIPC, RETN, GCK, PTPN1
38arginine459.5KCNJ11, PTPN1, SLC2A2, GCK, HMGA1, LIPC
39leucine459.5SLC2A2, GCK, HNF1A, KCNJ11
40metformin45 51 1311.5PPARG, KCNJ11, PTPN1, IRS2, RETN, GCK
41estrogen459.5PPARG, PTPN1, LIPC, IRS2, RETN, HNF1A
42serine459.5LIPC, HMGA1, GCK, ENPP1, PTPN1, IRS2
43atp45 3010.4LIPC, PTPN1, KCNJ11, ENPP1, GCGR, GCK
44fatty acid459.4GCK, HNF1A, LIPC, ENPP1, IRS2, RETN
45retinoic acid45 2610.3GCK, HMGA1, HNF1A, IRS2, PPARG
46calcium45 51 26 1312.2ENPP1, LIPC, KCNJ11, PTPN1, IRS2, RETN
47sterol459.1SLC2A2, LIPC, IRS2, RETN, HMGA1, GCK
48glycogen45 2610.1PTPN1, IRS2, LIPC, TCF7L2, ENPP1, SLC2A2
49lipid458.9ENPP1, PTPN1, IRS2, LIPH, HNF1A, PPARG
50glucose458.2PPARG, KCNJ11, PTPN1, TCF7L2, RETN, MTNR1B

GO Terms for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Cellular components related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058298.9PPARG, IGF2BP2, KCNJ11, PTPN1, IRS2, HMGA1
2plasma membraneGO:00058868.4KCNJ11, PTPN1, LIPH, IRS2, MTNR1B, GCGR

Biological processes related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of type B pancreatic cell apoptotic processGO:0200067510.4WFS1, TCF7L2
2positive regulation of glycogen biosynthetic processGO:004572510.3GCK, IRS2
3neurological system processGO:005087710.2WFS1, KCNJ11
4insulin secretionGO:003007310.2SLC30A8, HNF1A
5response to glucoseGO:000974910.2IRS2, TCF7L2, SLC30A8
6positive regulation of insulin secretionGO:003202410.2IRS2, TCF7L2, GCK, SLC30A8
7negative regulation of insulin receptor signaling pathwayGO:004662710.1PTPN1, ENPP1
8lipid homeostasisGO:005508810.0IRS2, PPARG
9cellular response to insulin stimulusGO:003286910.0ENPP1, GCK, IRS2, PPARG
10JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.9IRS2, PTPN1
11energy reserve metabolic processGO:00061129.9KCNJ11, GCGR, SLC2A2
12regulation of insulin secretionGO:00507969.8KCNJ11, MTNR1B, GCK, SLC2A2
13glucose homeostasisGO:00425939.5SLC30A8, PPARG, TCF7L2, MTNR1B, WFS1, HNF1A
14positive regulation of transcription, DNA-templatedGO:00458939.4HMGA1, HNF1A, TCF4, PPARG

Molecular functions related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1phospholipase activityGO:000462010.2LIPH, LIPC
2insulin receptor bindingGO:000515810.1IRS2, ENPP1, PTPN1
3retinoid X receptor bindingGO:004696510.0HMGA1, PPARG
4activating transcription factor bindingGO:00336139.9PPARG, WFS1
5transcription regulatory region DNA bindingGO:00442129.5HNF1A, TCF7L2, PPARG
6sequence-specific DNA binding transcription factor activityGO:00037009.5TCF4, TCF7L2, PPARG, HNF1A, HMGA1
7protein bindingGO:00055158.5HNF1A, HMGA1, IRS2, TCF4, GCK, ENPP1

Products for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Sources for Diabetes Mellitus, Noninsulin-Dependent

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet