MCID: DBT026
MIFTS: 36

Diabetes Mellitus, Noninsulin-Dependent malady

Summaries for Diabetes Mellitus, Noninsulin-Dependent

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46OMIM, 32MalaCards
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MalaCards: Diabetes Mellitus, Noninsulin-Dependent is related to diabetes mellitus and diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension. An important gene associated with Diabetes Mellitus, Noninsulin-Dependent is SLC30A8 (solute carrier family 30 (zinc transporter), member 8), and among its related pathways are IRS activation and Facilitative Na+-independent glucose transporters. The compounds estrogen and vanadium have been mentioned in the context of this disorder. Related mouse phenotypes are adipose tissue and liver/biliary system.

Description from OMIM:46 125853,135853

Aliases & Classifications for Diabetes Mellitus, Noninsulin-Dependent

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46OMIM
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Aliases & Descriptions:

diabetes mellitus, noninsulin-dependent 46


Related Diseases for Diabetes Mellitus, Noninsulin-Dependent

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17GeneCards, 18GeneDecks
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Diseases in the Diabetes Mellitus, Noninsulin-Dependent family:

Kcnj11-Related Susceptibility to Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Noninsulin-Dependent 1
Diabetes Mellitus, Noninsulin-Dependent, Late Onset Diabetes Mellitus, Noninsulin-Dependent, 2

Diseases related to Diabetes Mellitus, Noninsulin-Dependent via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus30.4SLC30A8, SLC2A2, SLC2A4, ABCC8, RETN, CDKAL1
2diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension10.6
3diabetes mellitus, noninsulin-dependent, 210.6
4diabetes mellitus, noninsulin-dependent 110.5
5diabetes mellitus, noninsulin-dependent, association with10.5
6diabetes mellitus, noninsulin-dependent, late onset10.5
7hypertension10.0RETN
8hepatitis10.0HNF4A
9hyperandrogenism10.0RETN
10familial hyperinsulinism10.0ABCC8
11essential hypertension10.0GCGR, RETN
12lipodystrophy10.0RETN
13glucose intolerance10.0RETN, IRS2, SLC2A4
14maturity-onset diabetes of the young10.0HNF1B, NEUROD1, HNF4A
15ischemia10.0SLC2A4, MAPK8IP1, ABCC8
16pituitary adenoma10.0ABCC8, NEUROD1
17rectal neoplasm10.0IRS2, IRS1
18hypertriglyceridemia10.0IRS1, LIPC, SLC2A4
19adenoma10.0HNF4A, HMGA1
20type 2 diabetes mellitus10.0SLC2A4, MAPK8IP1, IRS1, HNF1B
21liver cirrhosis10.0RETN, SLC2A4, IRS1
22myocardial infarction10.0RETN, LIPC
23fatty liver disease10.0RETN, HNF4A, LIPC
24hyperinsulinism10.0ABCC8, IRS1, IRS2, RETN
25insulinoma10.0SLC2A2, HNF4A, ABCC8
26neonatal diabetes mellitus10.0ABCC8, HNF1B, SLC2A2
27type 1 diabetes10.0LIPC, NEUROD1, HNF4A, RETN
28ischemic heart disease10.0ABCC8, LIPC, RETN
29metabolic syndrome x10.0HNF4A, RETN, SLC2A2, ABCC8
30polycystic ovary syndrome10.0IRS1, LIPC, RETN, SLC2A4, IRS2
31hypercholesterolemia10.0LIPC, RETN, HMGA1
32atherosclerosis10.0IRS2, RETN, LIPC, IRS1, HNF4A
33primary hyperoxaluria10.0LIPC, RETN, HNF1B
34galactosemia10.0HNF4A, HNF1B, IRS1, LIPC, RETN
35hypoglycemia10.0SLC2A2, GCGR, HNF4A, ABCC8, SLC2A4
36gestational diabetes10.0RETN, ABCC8, SLC2A4, IRS1, HNF4A, IRS2
37adenocarcinoma10.0SLC2A4, HNF4A, HNF1B, NEUROD1, HMGA1
38coronary heart disease10.0HMGA1, LIPC, IRS1, RETN
39pancreatic cancer10.0IRS2, SLC2A4, IRS1, HMGA1, HNF4A
40prostate cancer10.0IRS2, IRS1, MAPK8IP1, HNF1B, HNF4A, HMGA1
41hepatocellular carcinoma10.0IRS1, HNF1B, SLC2A2, LIPC, HNF4A, HMGA1
42obesity10.0HNF4A, GCGR, IRS2, SLC2A2, SLC2A4, IRS1
43insulin resistance9.9SLC2A4, HMGA1, ABCC8, RETN, GCGR, HNF4A
44hyperglycemia9.9GCGR, SLC2A2, SLC2A4, ABCC8, RETN, LIPC

Graphical network of the top 20 diseases related to Diabetes Mellitus, Noninsulin-Dependent:



Diseases related to diabetes mellitus, noninsulin-dependent

Clinical Features for Diabetes Mellitus, Noninsulin-Dependent

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46OMIM
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Clinical features from OMIM:

125853,135853

Drugs & Therapeutics for Diabetes Mellitus, Noninsulin-Dependent

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Diabetes Mellitus, Noninsulin-Dependent

Drug clinical trials:

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Search NIH Clinical Center for Diabetes Mellitus, Noninsulin-Dependent

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Genetic Tests for Diabetes Mellitus, Noninsulin-Dependent

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Anatomical Context for Diabetes Mellitus, Noninsulin-Dependent

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Animal Models for Diabetes Mellitus, Noninsulin-Dependent or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetes Mellitus, Noninsulin-Dependent:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.5SLC2A4, RETN, CDKAL1, IRS1, IRS2, GCGR
2MP:00053707.8HNF4A, HNF1B, IRS1, MAPK8IP1, CDKAL1, RETN
3MP:00053785.9NEUROD1, SLC2A2, SLC2A4, HMGA1, CDKAL1, MAPK8IP1
4MP:00053795.6SLC30A8, SLC2A4, HMGA1, ABCC8, CDKAL1, MAPK8IP1
5MP:00053765.0ABCC8, HMGA1, SLC30A8, GCGR, HNF4A, HNF1B

Publications for Diabetes Mellitus, Noninsulin-Dependent

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Genetic Variations for Diabetes Mellitus, Noninsulin-Dependent

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent:

62 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Expression for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

Search GEO for disease gene expression data for Diabetes Mellitus, Noninsulin-Dependent.

Pathways for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 4Cell Signaling Technology, 49PharmGKB
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Pathways related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8IRS1, IRS2
29.6SLC2A4, SLC2A2
39.5IRS2, IRS1, SLC2A4
49.5IRS2, IRS1, SLC2A4
59.5SLC2A4, IRS1, IRS2
6
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9.3GCGR, SLC2A2, ABCC8
7
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9.3IRS2, IRS1, RETN, SLC2A4
89.2SLC2A2, SLC2A4, HNF4A
9
Development Prolactin receptor signaling
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9.2IRS1, SLC2A2, IRS2
109.2HNF4A, ABCC8, SLC2A2
11
Development Leptin signaling via PI3K-dependent pathway
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9.2ABCC8, SLC2A4, IRS2, IRS1
129.0HMGA1, IRS1, IRS2
139.0IRS1, HMGA1, IRS2
14
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9.0SLC2A2, HNF4A, HNF1B, NEUROD1
159.0SLC2A4, NEUROD1, IRS1, IRS2, HNF4A
16
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8.7SLC2A4, SLC2A2, HMGA1
178.4SLC2A4, HMGA1, IRS1, IRS2, RETN
18
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7.7HNF1B, HNF4A, IRS2, IRS1, NEUROD1, ABCC8

Compounds for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1estrogen4410.3LIPC
2vanadium4410.1IRS1, SLC2A4
3repaglinide44 49 1112.0ABCC8, NEUROD1
4glimepiride44 49 1112.0ABCC8, RETN, SLC2A4
5[3h]2-deoxyglucose2810.0SLC2A2, SLC2A4
6thiazolidinedione449.9RETN, SLC2A4, IRS1
73-o-methylglucose449.9SLC2A4, SLC2A2
82,4-dinitrophenol449.9SLC2A4, IRS1
9glucosamine44 11 2411.9SLC2A4, IRS2, IRS1
10incretin449.8SLC2A2, GCGR
11anisomycin44 1110.8IRS2, IRS1, SLC2A4
12glibenclamide44 28 49 5912.7LIPC, SLC2A4, ABCC8
13fructose44 1110.7SLC2A2, GCGR, SLC2A4
14rosiglitazone44 49 28 11 2413.7SLC2A4, RETN, IRS2, IRS1
15palmitate449.6HNF4A, IRS1, SLC2A4
16phosphotyrosine449.6IRS2, SLC2A4, MAPK8IP1, IRS1
17okadaic acid44 5910.6HNF4A, IRS2, SLC2A4, IRS1
18streptozotocin449.5SLC2A2, SLC2A4, IRS1
19troglitazone44 28 59 1112.5SLC2A4, IRS1, IRS2
202-deoxyglucose44 1110.5SLC2A4, IRS1, SLC2A2
21pioglitazone44 49 28 1112.5RETN, SLC2A4, LIPC, IRS1
22pd 98,059449.4HNF4A, IRS1, SLC2A4, IRS2
23p002449.4LIPC, RETN, HNF4A
24dexamethasone44 49 28 1112.4IRS1, SLC2A4, RETN, HNF4A
25glycerol44 11 2411.4LIPC, IRS1, HNF4A, SLC2A4
26metformin44 49 1111.4RETN, IRS1, ABCC8, IRS2, SLC2A4
27phosphoenolpyruvate44 1110.3SLC2A4, IRS1, HNF4A, SLC2A2
28sulfonylurea449.3ABCC8, IRS1, SLC2A2, SLC2A4
29phosphatidylinositol-3,4,5-trisphosphate44 2410.2IRS1, IRS2, SLC2A4
30lovastatin44 49 59 28 1113.0IRS1, LIPC, HMGA1
31oligonucleotide449.0GCGR, SLC2A2, IRS2, HNF1B, HNF4A
32atorvastatin44 49 28 11 2413.0LIPC, HMGA1, RETN
33rapamycin449.0HMGA1, IRS1, SLC2A4, IRS2
34ly294002448.8IRS2, SLC2A4, IRS1, RETN, HMGA1
35phosphatidylinositol448.8HNF4A, SLC2A4, RETN, IRS1, IRS2
36c-peptide448.8IRS1, LIPC, RETN, SLC2A2, HNF4A
37testosterone44 59 11 2411.8HNF4A, SLC2A4, LIPC, RETN, ABCC8, IRS1
38atp44 289.6HNF4A, ABCC8, SLC2A2, MAPK8IP1, GCGR, LIPC
39cholesterol44 28 11 2411.4HMGA1, ABCC8, RETN, LIPC, HNF1B, HNF4A
40retinoic acid44 249.3HNF4A, SLC2A4, HMGA1, NEUROD1, IRS1, IRS2
41threonine448.1HNF4A, SLC2A4, HMGA1, MAPK8IP1, LIPC, IRS1
42serine447.8MAPK8IP1, ABCC8, LIPC, IRS1, IRS2, HNF4A
43glycogen44 248.7SLC2A4, SLC2A2, GCGR, ABCC8, HNF4A, IRS2
44calcium44 49 11 2410.7MAPK8IP1, GCGR, IRS2, HNF4A, NEUROD1, LIPC
45tyrosine447.7HMGA1, SLC2A4, RETN, LIPC, IRS1, IRS2
46arginine447.6LIPC, SLC2A2, HMGA1, ABCC8, HNF1B, HNF4A
47fatty acid447.5ABCC8, RETN, LIPC, IRS1, IRS2, HNF4A
48sterol447.5IRS1, RETN, HMGA1, SLC2A4, SLC2A2, HNF4A
49lipid447.2IRS2, IRS1, LIPH, LIPC, RETN, ABCC8
50glucose446.2HNF4A, HMGA1, SLC2A2, SLC2A4, ABCC8, RETN

GO Terms for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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16Gene Ontology
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Biological processes related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glucose metabolic processGO:01090710.0IRS1, IRS2
2lipid homeostasisGO:05508810.0HNF4A, IRS2
3positive regulation of fatty acid beta-oxidationGO:03200010.0IRS1, IRS2
4signal transduction involved in regulation of gene expressionGO:02301910.0HNF4A, NEUROD1
5insulin secretionGO:03007310.0SLC30A8, NEUROD1, HNF1B
6positive regulation of glycogen biosynthetic processGO:04572510.0IRS1, IRS2
7regulation of lipid metabolic processGO:0192169.9HNF4A, IRS2
8JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.8IRS1, IRS2
9cellular response to insulin stimulusGO:0328699.8IRS2, IRS1, SLC2A4
10triglyceride homeostasisGO:0703289.6LIPC, HNF4A
11mammary gland developmentGO:0308799.5IRS1, IRS2
12energy reserve metabolic processGO:0061129.5GCGR, ABCC8, SLC2A2
13response to glucose stimulusGO:0097499.4HNF4A, HNF1B, IRS2, NEUROD1, SLC30A8
14endocrine pancreas developmentGO:0310189.3HNF4A, HNF1B, NEUROD1, SLC2A2
15regulation of insulin secretionGO:0507969.2HNF4A, NEUROD1, ABCC8, SLC2A2
16glucose homeostasisGO:0425939.1SLC30A8, SLC2A4, NEUROD1, IRS1, HNF4A, GCGR

Molecular functions related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol 3-kinase bindingGO:0435489.8IRS1, IRS2
2D-glucose transmembrane transporter activityGO:0550569.5SLC2A2, SLC2A4
3phospholipase activityGO:0046209.2LIPH, LIPC

Products for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Sources for Diabetes Mellitus, Noninsulin-Dependent

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
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