MCID: DBT026
MIFTS: 39

Diabetes Mellitus, Noninsulin-Dependent malady

Genetic diseases (common) category

Summaries for Diabetes Mellitus, Noninsulin-Dependent

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48OMIM, 34MalaCards
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MalaCards: Diabetes Mellitus, Noninsulin-Dependent is related to diabetes mellitus and diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension. An important gene associated with Diabetes Mellitus, Noninsulin-Dependent is SLC30A8 (solute carrier family 30 (zinc transporter), member 8), and among its related pathways are Growth hormone receptor signaling and IGF1 pathway. The compounds [3h]2-deoxyglucose and 3-o-methylglucose have been mentioned in the context of this disorder. Related mouse phenotypes are adipose tissue and liver/biliary system.

Description from OMIM:48 125853,135853

Aliases & Classifications for Diabetes Mellitus, Noninsulin-Dependent

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48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

diabetes mellitus, noninsulin-dependent 48


Related Diseases for Diabetes Mellitus, Noninsulin-Dependent

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Diabetes Mellitus, Noninsulin-Dependent family:

Kcnj11-Related Susceptibility to Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Noninsulin-Dependent 1
Diabetes Mellitus, Noninsulin-Dependent, Late Onset Diabetes Mellitus, Noninsulin-Dependent, 2

Diseases related to Diabetes Mellitus, Noninsulin-Dependent via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus30.1SLC30A8, ABCC8, IGF2BP2, SLC2A2, SLC2A4, CDKAL1
2diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension10.6
3diabetes mellitus, noninsulin-dependent, 210.6
4diabetes mellitus, noninsulin-dependent 110.5
5diabetes mellitus, noninsulin-dependent, association with10.5
6diabetes mellitus, noninsulin-dependent, late onset10.5
7hepatic lipase deficiency10.1LIPC
8familial hyperinsulinism10.1ABCC8
9hyperinsulinemic hypoglycemia10.1ABCC8
10maturity-onset diabetes of the young10.1NEUROD1, HNF1B, HNF4A
11neonatal diabetes mellitus10.1ABCC8, HNF1B, SLC2A2
12cholestasis10.0LIPC, HNF1B, HNF4A
13rectal neoplasm10.0IRS2, IRS1
14polycystic ovary syndrome10.0IRS2, IRS1, INSR
15uremia10.0RETN, LIPC, INSR
16glucose intolerance10.0SLC2A4, RETN, IRS2, INSR
17galactosemia10.0LIPC, IRS1, RETN, HNF1B, HNF4A
18coronary artery disease10.0LIPC, IRS1, RETN
19liver cirrhosis10.0INSR, IRS1, RETN, SLC2A4
20hypercholesterolemia10.0RETN, LIPC, INSR
21hypertriglyceridemia10.0INSR, LIPC, IRS1, SLC2A4
22lipodystrophy10.0RETN, AKT2, INSR
23fatty liver disease10.0INSR, LIPC, RETN, HNF4A
24sepsis10.0INSR, IRS1, RETN, SLC2A4
25insulinoma10.0ABCC8, INSR, HNF4A, SLC2A2
26primary hyperoxaluria10.0HNF1B, RETN, LIPC
27atherosclerosis10.0LIPC, IRS1, IRS2, RETN, HNF4A
28kidney cancer10.0INSR, HNF1B, HNF4A, SLC2A4
29pancreatic cancer10.0IRS1, IRS2, AKT2, HNF4A, SLC2A4
30hypoglycemia10.0ABCC8, INSR, HNF4A, SLC2A4, SLC2A2
31metabolic syndrome x10.0SLC2A2, HNF4A, RETN, INSR, ABCC8
32type 1 diabetes mellitus10.0INSR, LIPC, NEUROD1, RETN, HNF4A
33ovarian cancer10.0INSR, AKT2, HNF1B, HNF4A, SLC2A4
34hyperinsulinism10.0ABCC8, INSR, IRS1, IRS2, RETN
35hepatocellular carcinoma10.0SLC2A2, HNF4A, HNF1B, IRS1, LIPC, INSR
36ischemia10.0SLC2A4, MAPK8IP1, INSR, ABCC8
37tongue squamous cell carcinoma9.9INSR, IRS1, IRS2, AKT2, HNF4A, SLC2A4
38adenocarcinoma9.9INSR, NEUROD1, AKT2, HNF1B, HNF4A, SLC2A4
39gestational diabetes9.9SLC2A4, HNF4A, RETN, IRS2, IRS1, INSR
40colorectal cancer9.9PPP1R3A, INSR, IRS1, IRS2, HNF4A
41prostate cancer9.9INSR, IRS1, IRS2, AKT2, MAPK8IP1, HNF1B
42breast cancer9.9INSR, IRS1, IRS2, AKT2, HNF4A, SLC2A4
43obesity9.9ABCC8, INSR, LIPC, IRS1, IRS2, RETN
44hyperglycemia9.8HNF1B, RETN, IRS2, IRS1, NEUROD1, LIPC
45type 2 diabetes mellitus9.7SLC2A2, SLC2A4, HNF4A, HNF1B, RETN, IRS2
46insulin resistance9.7SLC2A4, HNF4A, HNF1B, RETN, AKT2, IRS2

Graphical network of the top 20 diseases related to Diabetes Mellitus, Noninsulin-Dependent:



Diseases related to diabetes mellitus, noninsulin-dependent

Symptoms for Diabetes Mellitus, Noninsulin-Dependent

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48OMIM
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Clinical features from OMIM:

125853,135853

Drugs & Therapeutics for Diabetes Mellitus, Noninsulin-Dependent

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Diabetes Mellitus, Noninsulin-Dependent

Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus, Noninsulin-Dependent

Search NIH Clinical Center for Diabetes Mellitus, Noninsulin-Dependent

Search CenterWatch for Diabetes Mellitus, Noninsulin-Dependent

Genetic Tests for Diabetes Mellitus, Noninsulin-Dependent

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Anatomical Context for Diabetes Mellitus, Noninsulin-Dependent

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Animal Models for Diabetes Mellitus, Noninsulin-Dependent or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Diabetes Mellitus, Noninsulin-Dependent:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053757.7CDKAL1, RETN, AKT2, IRS2, IRS1, SLC2A4
2MP:00053707.6MAPK8IP1, SLC2A4, CDKAL1, HNF4A, RETN, AKT2
3MP:00053697.6IRS2, PPP1R3A, INSR, IRS1, HNF1B, AKT2
4MP:00107687.6SLC2A4, HNF4A, HNF1B, MAPK8IP1, AKT2, IRS2
5MP:00053847.5CDKAL1, SLC2A2, INSR, NEUROD1, IRS1, IRS2
6MP:00053796.9INSR, SLC2A4, CDKAL1, HNF1B, MAPK8IP1, AKT2
7MP:00053786.7PPP1R3A, SLC2A2, INSR, NEUROD1, SLC30A8, SLC2A4
8MP:00053765.8LIPC, IRS2, INSR, ABCC8, PPP1R3A, AKT2

Publications for Diabetes Mellitus, Noninsulin-Dependent

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Variations for Diabetes Mellitus, Noninsulin-Dependent

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent:

65 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent:

1 (show all 15)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
3AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
4INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
5INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenic, Pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
6GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
7SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
8GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
9IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
10IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
11MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
12NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
13ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
14ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
15HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

Search GEO for disease gene expression data for Diabetes Mellitus, Noninsulin-Dependent.

Pathways for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 13EMD Millipore, 31KEGG, 62Tocris Bioscience, 55R&D Systems, 5Cell Signaling Technology, 52PharmGKB
See all sources

Pathways related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IRS2, IRS1
29.9IRS2, IRS1
39.9SLC2A4, HNF4A, SLC2A2
49.7ABCC8, SLC2A2, HNF4A
59.5IRS2, RETN, SLC2A4, IRS1
6
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.5IRS1, AKT2, IRS2
7
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.5IRS1, IRS2, AKT2
8
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.3IRS1, IRS2, AKT2, SLC2A2
9
Show member pathways
9.3IRS2, IRS1, SLC2A4, AKT2
109.3AKT2, IRS2, IRS1, SLC2A4
11
Show member pathways
9.3INSR, NEUROD1, SLC2A2, HNF4A
12
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.2AKT2, INSR, IRS1
13
Show member pathways
Insulin Pathway39
9.2IRS1, AKT2, INSR
149.1INSR, AKT2, HNF4A, SLC2A4
15
Show member pathways
9.1SLC2A2, NEUROD1, AKT2, HNF1B, HNF4A
16
Show member pathways
8.9INSR, IRS1, AKT2, IRS2
17
Show member pathways
8.9IRS1, AKT2, IRS2, INSR
18
Show member pathways
8.9SLC2A2, SLC2A4, HNF4A, HNF1B, AKT2, NEUROD1
19
Show member pathways
8.9INSR, AKT2, PPP1R3A
208.9IRS2, IRS1, ABCC8, SLC2A4, AKT2
21
Show member pathways
8.8SLC2A4, AKT2, IRS1, INSR, MAPK8IP1
22
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
8.8AKT2, IRS1, IRS2, SLC2A4, INSR
23
Show member pathways
8.8IRS1, INSR, IRS2, AKT2, SLC2A4
24
Show member pathways
8.8IRS1, SLC2A4, AKT2, IRS2, INSR
258.7PPP1R3A, INSR, AKT2, SLC2A4
26
Show member pathways
8.6IRS2, IRS1, INSR, SLC2A4, PPP1R3A
27
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.5SLC2A4, RETN, AKT2, IRS2, IRS1, INSR
28
Show member pathways
8.5HNF4A, IRS1, MAPK8IP1, AKT2, IRS2, INSR
298.2NEUROD1, INSR, SLC2A4, HNF4A, AKT2, IRS2
308.1PPP1R3A, INSR, IRS1, AKT2, SLC2A4, IRS2
31
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
8.1INSR, PPP1R3A, SLC2A4, IRS2, AKT2, IRS1
32
Show member pathways
7.9SLC2A4, ABCC8, INSR, NEUROD1, IRS1, IRS2
33
Show member pathways
7.9PPP1R3A, AKT2, IRS2, INSR, MAPK8IP1, IRS1

Compounds for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Sources:
30IUPHAR, 46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB
See all sources

Compounds related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1[3h]2-deoxyglucose3010.3SLC2A4, SLC2A2
23-o-methylglucose4610.0INSR, SLC2A2, SLC2A4
3thiazolidinedione4610.0RETN, SLC2A4, IRS1
4phosphoenolpyruvate46 1211.0SLC2A2, HNF4A, IRS1, SLC2A4
5repaglinide52 46 1212.0ABCC8, SLC30A8, NEUROD1
6vanadium469.9INSR, IRS1, SLC2A4
7sulfonylurea469.8SLC2A4, IRS1, SLC2A2, ABCC8
8streptozotocin469.7SLC2A2, IRS1, SLC2A4, INSR
9phenylarsine oxide469.7SLC2A4, IRS1, INSR
10gliclazide46 52 1211.7SLC2A4, INSR, ABCC8
11okadaic acid46 6210.7IRS1, HNF4A, SLC2A4, IRS2
12glucosamine46 25 1211.6IRS2, INSR, IRS1, SLC2A4
13palmitate469.6SLC2A4, HNF4A, IRS1, INSR
14ibmx46 62 3011.6INSR, IRS1, SLC2A4, SLC2A2
15anisomycin46 1210.6INSR, SLC2A4, IRS2, IRS1
16glimepiride46 52 1211.5ABCC8, INSR, SLC2A4, RETN
17phosphatidylinositol-3,4,5-trisphosphate46 2510.5IRS2, INSR, IRS1, SLC2A4
18troglitazone46 30 62 1212.5SLC2A4, IRS2, IRS1, INSR
19fenofibrate46 52 1211.5RETN, INSR, LIPC
20glibenclamide46 30 52 6212.4SLC2A4, INSR, ABCC8, LIPC
21rosiglitazone30 46 52 25 1213.4IRS1, INSR, RETN, SLC2A4, IRS2
22vanadyl sulfate469.4IRS1, INSR
23pioglitazone30 46 52 1212.3RETN, IRS1, INSR, SLC2A4, LIPC
24glycerol46 25 1211.3SLC2A4, INSR, LIPC, IRS1, HNF4A
25phosphotyrosine469.3SLC2A4, IRS2, IRS1, INSR, MAPK8IP1
26pd 98,059469.3IRS2, INSR, IRS1, SLC2A4, HNF4A
27tamoxifen46 52 30 1212.3IRS1, SLC2A4, AKT2, IRS2
28sterol469.2SLC2A4, RETN, IRS2, IRS1, LIPC, HNF4A
29c-peptide469.1INSR, LIPC, SLC2A2, HNF4A, RETN, IRS1
302-deoxyglucose46 1210.1INSR, SLC2A2, SLC2A4, PPP1R3A, IRS1
31rapamycin469.1AKT2, INSR, SLC2A4, IRS2, IRS1
32wortmannin469.0SLC2A4, AKT2, IRS2, IRS1, INSR
33cycloheximide469.0IRS2, INSR, IRS1, RETN, SLC2A4
34metformin46 52 1211.0ABCC8, RETN, IRS1, IRS2, INSR, SLC2A4
35dexamethasone46 52 30 1212.0INSR, SLC2A4, IRS2, RETN, HNF4A, IRS1
36retinoic acid46 2510.0HNF4A, NEUROD1, IRS1, IRS2, HNF1B, SLC2A4
37fatty acid469.0RETN, HNF4A, IRS2, IRS1, LIPC, ABCC8
38alanine468.9IRS1, INSR, RETN, HNF4A, SLC2A4, IRS2
39sb 20358046 629.9INSR, IRS1, AKT2, SLC2A4
40ly294002468.9INSR, IRS2, RETN, SLC2A4, AKT2, IRS1
41testosterone46 62 25 1211.7HNF4A, RETN, IRS1, LIPC, INSR, ABCC8
42arginine468.7INSR, ABCC8, IRS1, HNF1B, HNF4A, SLC2A2
43phosphatidylinositol468.7INSR, IRS2, AKT2, RETN, HNF4A, SLC2A4
44estrogen468.5INSR, RETN, AKT2, IRS2, LIPC, IRS1
45threonine468.4IRS1, SLC2A4, HNF4A, MAPK8IP1, AKT2, IRS2
46serine468.0SLC2A4, MAPK8IP1, IRS2, IRS1, AKT2, HNF4A
47tyrosine467.9RETN, HNF4A, AKT2, IRS2, IRS1, LIPC
48glycogen46 258.2SLC2A2, INSR, IRS1, IRS2, AKT2, RETN
49lipid467.0IRS2, ABCC8, PPP1R3A, SLC2A4, HNF4A, RETN
50glucose466.4RETN, AKT2, IRS2, IRS1, NEUROD1, LIPC

GO Terms for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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17Gene Ontology
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Cellular components related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor complexGO:0058999.4IRS1, INSR
2plasma membraneGO:0058867.7INSR, LIPH, IRS1, IRS2, AKT2, SLC2A4

Biological processes related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1lipid homeostasisGO:05508810.1HNF4A, IRS2
2regulation of lipid metabolic processGO:01921610.1IRS2, HNF4A
3insulin secretionGO:03007310.0SLC30A8, HNF1B, NEUROD1
4negative regulation of plasma membrane long-chain fatty acid transportGO:01074810.0AKT2, IRS2
5positive regulation of glucose import in response to insulin stimulusGO:200127510.0IRS1, AKT2
6triglyceride homeostasisGO:0703289.9HNF4A, LIPC
7JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.9IRS2, IRS1
8regulation of cell cycle arrestGO:0711569.9NEUROD1, AKT2
9signal transduction involved in regulation of gene expressionGO:0230199.9HNF4A, NEUROD1
10endocrine pancreas developmentGO:0310189.8NEUROD1, HNF1B, HNF4A, SLC2A2
11positive regulation of glucose metabolic processGO:0109079.8AKT2, IRS2, IRS1
12positive regulation of fatty acid beta-oxidationGO:0320009.8AKT2, IRS2, IRS1
13regulation of insulin secretionGO:0507969.6ABCC8, NEUROD1, HNF4A, SLC2A2
14mammary gland developmentGO:0308799.6IRS2, IRS1
15response to glucoseGO:0097499.6NEUROD1, IRS2, HNF1B, HNF4A, SLC30A8
16positive regulation of cell migrationGO:0303359.6IRS2, IRS1, INSR
17carbohydrate metabolic processGO:0059759.4ABCC8, INSR, SLC2A4, SLC2A2
18positive regulation of glycogen biosynthetic processGO:0457259.3INSR, IRS1, IRS2, AKT2
19positive regulation of glucose importGO:0463269.3INSR, IRS1, IRS2, AKT2
20insulin receptor signaling pathwayGO:0082869.2INSR, IRS1, IRS2, AKT2
21glucose homeostasisGO:0425939.1SLC30A8, SLC2A4, HNF4A, IRS1, NEUROD1, INSR
22cellular response to insulin stimulusGO:0328699.1SLC2A4, AKT2, IRS2, IRS1, INSR

Molecular functions related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1D-glucose transmembrane transporter activityGO:05505610.1SLC2A2, SLC2A4
2insulin receptor bindingGO:0051589.9IRS2, IRS1
3phospholipase activityGO:0046209.7LIPH, LIPC
4phosphatidylinositol 3-kinase bindingGO:0435489.5IRS2, IRS1, INSR
5insulin-like growth factor receptor bindingGO:0051599.4IRS1, INSR

Products for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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  • Antibodies
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Sources for Diabetes Mellitus, Noninsulin-Dependent

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet