MCID: DBT026
MIFTS: 40

Diabetes Mellitus, Noninsulin-Dependent malady

Genetic diseases (common) category
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Summaries for Diabetes Mellitus, Noninsulin-Dependent

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MalaCards based summary: Diabetes Mellitus, Noninsulin-Dependent is related to diabetes mellitus and diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension. An important gene associated with Diabetes Mellitus, Noninsulin-Dependent is SLC30A8 (solute carrier family 30 (zinc transporter), member 8), and among its related pathways are IGF1 pathway and Growth hormone receptor signaling. The compounds repaglinide and [3h]2-deoxyglucose have been mentioned in the context of this disorder. Related mouse phenotypes are cellular and reproductive system.

Descriptions from OMIM:46 125853,135853

Aliases & Classifications for Diabetes Mellitus, Noninsulin-Dependent

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Diabetes Mellitus, Noninsulin-Dependent, Aliases & Descriptions:

Name: Diabetes Mellitus, Noninsulin-Dependent 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Diabetes Mellitus, Noninsulin-Dependent

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Diseases in the Diabetes Mellitus, Noninsulin-Dependent family:

Kcnj11-Related Susceptibility to Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Noninsulin-Dependent 1
Diabetes Mellitus, Noninsulin-Dependent, Late Onset Diabetes Mellitus, Noninsulin-Dependent, 2

Diseases related to Diabetes Mellitus, Noninsulin-Dependent via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus29.6ABCC8, SLC30A8, SLC2A2, INSR, PAX4, IRS1
2diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension10.6
3diabetes mellitus, noninsulin-dependent, 210.6
4diabetes mellitus, noninsulin-dependent 110.5
5diabetes mellitus, noninsulin-dependent, association with10.5
6diabetes mellitus, noninsulin-dependent, late onset10.5
7familial hyperinsulinism10.5ABCC8
8hyperinsulinemic hypoglycemia10.4ABCC8
9neonatal diabetes mellitus10.4SLC2A2, HNF1B, ABCC8
10maturity-onset diabetes of the young10.4PAX4, HNF4A, HNF1B
11polycystic ovary syndrome10.3INSR, IRS2, IRS1
12fatty liver disease10.3INSR, HNF4A, RETN
13lipodystrophy10.3AKT2, INSR, RETN
14hypercholesterolemia10.3HMGA1, RETN, INSR
15galactosemia10.3IRS1, HNF1B, HNF4A, RETN
16hypertriglyceridemia10.2SLC2A4, INSR, IRS1
17type 1 diabetes mellitus10.2HNF4A, RETN, PAX4, INSR
18essential hypertension10.2RETN, GCGR, INSR
19coronary artery anomaly10.2HMGA1, RETN, IRS1
20primary hyperoxaluria10.2INSR, HNF4A, HNF1B, RETN
21metabolic syndrome x10.2HNF4A, RETN, SLC2A2, INSR, ABCC8
22rectal neoplasm10.2IRS2, IRS1
23liver cirrhosis10.2INSR, RETN, SLC2A4, IRS1
24hyperinsulinism10.2INSR, RETN, IRS2, IRS1, ABCC8
25atherosclerosis10.1IRS2, RETN, HNF4A, IRS1
26sepsis10.1INSR, RETN, SLC2A4, IRS1
27liver cancer10.1HNF4A, HMGA1, SLC2A2, IRS1, INSR, HNF1B
28kidney cancer10.1HNF1B, SLC2A4, HNF4A, INSR
29glucose intolerance10.1IRS2, INSR, SLC2A4, PAX4, RETN
30ovarian cancer10.1INSR, AKT2, HNF1B, SLC2A4, HNF4A
31colorectal cancer10.0INSR, HNF4A, PPP1R3A, IRS2, IRS1
32hypoglycemia10.0SLC2A4, INSR, HNF4A, SLC2A2, ABCC8, GCGR
33pancreatic cancer10.0AKT2, HNF4A, HMGA1, SLC2A4, IRS1, IRS2
34ischemia10.0SLC2A4, ABCC8, INSR, MAPK8IP1
35insulinoma10.0SLC2A2, ABCC8, GPD2, INSR, PAX4, HNF4A
36adenocarcinoma10.0HMGA1, HNF1B, HNF4A, AKT2, INSR, SLC2A4
37tongue squamous cell carcinoma9.9IRS1, AKT2, HNF4A, SLC2A4, IRS2, INSR
38prostate cancer9.9AKT2, INSR, MAPK8IP1, HNF1B, IRS2, IRS1
39gestational diabetes9.9ABCC8, INSR, IRS1, IRS2, RETN, HNF4A
40breast cancer9.8SLC2A2, IRS2, AKT2, HNF4A, HMGA1, INSR
41obesity9.8SLC2A2, IRS2, SLC2A4, GCGR, ABCC8, INSR
42type 2 diabetes mellitus9.8PPP1R3A, INSR, IRS1, AKT2, MAPK8IP1, HNF1B
43hyperglycemia9.6ABCC8, INSR, PAX4, IRS1, IRS2, RETN
44insulin resistance9.3HMGA1, GCGR, SLC2A4, HNF4A, PPP1R3A, ABCC8

Graphical network of the top 20 diseases related to Diabetes Mellitus, Noninsulin-Dependent:



Diseases related to diabetes mellitus, noninsulin-dependent

Symptoms for Diabetes Mellitus, Noninsulin-Dependent

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Clinical features from OMIM:

125853,135853

Drugs & Therapeutics for Diabetes Mellitus, Noninsulin-Dependent

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Drug clinical trials:

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Search NIH Clinical Center for Diabetes Mellitus, Noninsulin-Dependent

Genetic Tests for Diabetes Mellitus, Noninsulin-Dependent

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Anatomical Context for Diabetes Mellitus, Noninsulin-Dependent

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Animal Models for Diabetes Mellitus, Noninsulin-Dependent or affiliated genes

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MGI Mouse Phenotypes related to Diabetes Mellitus, Noninsulin-Dependent:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.9CDKAL1, INSR, IRS1, AKT2, MAPK8IP1, HNF4A
2MP:00053898.7AKT2, IRS2, INSR, GPD2, MAPK8IP1, GCGR
3MP:00053698.5AKT2, SLC2A2, SLC2A4, HNF1B, IRS2, IRS1
4MP:00053758.2PPP1R3A, SLC2A4, RETN, AKT2, IRS2, IRS1
5MP:00053708.1INSR, SLC2A2, SLC2A4, HNF4A, HNF1B, MAPK8IP1
6MP:00107687.9INSR, PAX4, IRS1, IRS2, AKT2, MAPK8IP1
7MP:00053797.5MAPK8IP1, IRS2, AKT2, HNF1B, GCGR, CDKAL1
8MP:00053787.2MAPK8IP1, HNF4A, SLC2A2, SLC2A4, CDKAL1, GCGR
9MP:00053767.1GPD2, HNF1B, ABCC8, PPP1R3A, INSR, HMGA1

Publications for Diabetes Mellitus, Noninsulin-Dependent

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Variations for Diabetes Mellitus, Noninsulin-Dependent

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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent:

64 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent:

6 (show all 32)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
3ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
4PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
5AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
6SLC30A8NM_173851.2(SLC30A8): c.412C> T (p.Arg138Ter)single nucleotide variantprotectivers200185429GRCh37Chr 8, 118165323: 118165323
7SLC30A8NM_173851.2(SLC30A8): c.101_107delAAGATCA (p.Lys34Serfs)deletionprotectiveGRCh37Chr 8, 118159222: 118159228
8LIPCLIPC, -250G-Asingle nucleotide variantrisk factor
9INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
10INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
11IL6IL6, -174G-Csingle nucleotide variantrisk factor
12GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
13SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
14GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
15IGF2BP2NM_006548.4(IGF2BP2): c.239+29254C> Asingle nucleotide variantrisk factorrs4402960GRCh37Chr 3, 185511687: 185511687
16IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
17IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
18HMGA1HMGA1, 1-BP INS, IVS5, -13insertionrisk factor
19RETNRETN, +62G-Asingle nucleotide variantrisk factor
20CAPN10NM_023083.3(CAPN10): c.471-176G> Asingle nucleotide variantrisk factorrs3792267GRCh37Chr 2, 241531174: 241531174
21CAPN10CAPN10, IVS6, INS/DEL, 39-BPindelrisk factor
22CAPN10CAPN10, IVS13, g.16378G-Tsingle nucleotide variantrisk factor
23CAPN10CAPN10, IVS3, g.4841T-Csingle nucleotide variantrisk factor
24MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
25TCF7L2NM_030756.4(TCF7L2): c.382-41435C> Tsingle nucleotide variantrisk factorrs7903146GRCh37Chr 10, 114758349: 114758349
26TCF7L2NM_030756.4(TCF7L2): c.483+9017G> Tsingle nucleotide variantrisk factorrs12255372GRCh37Chr 10, 114808902: 114808902
27TCF7L2NM_030756.4(TCF7L2): c.483+7162G> Csingle nucleotide variantrisk factorrs11196205GRCh37Chr 10, 114807047: 114807047
28NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
29KCNJ11NM_000525.3(KCNJ11): c.67A> G (p.Lys23Glu)single nucleotide variantdrug response, risk factorrs5219GRCh37Chr 11, 17409572: 17409572
30ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
31ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
32HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

Search GEO for disease gene expression data for Diabetes Mellitus, Noninsulin-Dependent.

Pathways for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Pathways related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IRS1, IRS2
210.1IRS1, IRS2
3
Show member pathways
9.9SLC2A2, ABCC8, GCGR
49.9HMGA1, IRS2, IRS1
59.9HMGA1, IRS2, IRS1
69.9SLC2A2, ABCC8, HNF4A
7
Show member pathways
9.9SLC2A2, INSR, HNF4A
8
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.8IRS1, AKT2, IRS2
9
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.8AKT2, IRS2, IRS1
10
Show member pathways
9.8HMGA1, SLC2A2, SLC2A4
119.8HNF4A, SLC2A2, SLC2A4
12
Show member pathways
Insulin Pathway37
9.7AKT2, IRS1, INSR
13
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.7IRS1, AKT2, INSR
14
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.7IRS1, AKT2, IRS2, SLC2A2
15
Show member pathways
9.6INSR, PPP1R3A, AKT2
16
Show member pathways
9.6INSR, IRS1, IRS2, AKT2
17
Show member pathways
9.6IRS2, INSR, IRS1, AKT2
18
Show member pathways
9.5AKT2, SLC2A4, IRS1, IRS2
199.5SLC2A4, IRS2, IRS1, AKT2
20
Show member pathways
9.5HNF4A, HNF1B, AKT2, PAX4, SLC2A2
219.4INSR, AKT2, HNF4A, SLC2A4
229.4IRS1, IRS2, RETN, SLC2A4, HMGA1
239.3SLC2A4, AKT2, INSR, PPP1R3A
249.3IRS1, ABCC8, IRS2, AKT2, SLC2A4
25
Show member pathways
9.2INSR, SLC2A4, IRS1, AKT2, MAPK8IP1
26
Show member pathways
9.2IRS1, AKT2, MAPK8IP1, HNF4A, IRS2, INSR
27
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.2SLC2A4, IRS2, INSR, IRS1, AKT2
28
Show member pathways
9.2INSR, IRS1, IRS2, AKT2, SLC2A4
29
Show member pathways
9.2IRS2, AKT2, SLC2A4, INSR, IRS1
30
Show member pathways
9.1SLC2A4, IRS1, INSR, PPP1R3A, IRS2
31
Show member pathways
9.1PAX4, AKT2, SLC2A2, SLC2A4, HNF4A, HNF1B
329.1HNF4A, SLC2A4, IRS1, INSR, IRS2, AKT2
33
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.0SLC2A4, INSR, IRS1, RETN, AKT2, IRS2
34
Show member pathways
8.9IRS2, IRS1, AKT2, MAPK8IP1, INSR, PPP1R3A
358.9SLC2A4, AKT2, IRS2, PPP1R3A, INSR, IRS1
36
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.9IRS2, INSR, PPP1R3A, IRS1, SLC2A4, AKT2
37
Show member pathways
8.8INSR, SLC2A2, SLC2A4, HNF4A, HNF1B, IRS2

Compounds for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Compounds related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1repaglinide50 44 1112.2ABCC8, SLC30A8, PAX4
2[3h]2-deoxyglucose2810.2SLC2A4, SLC2A2
33-o-methylglucose4410.1SLC2A2, SLC2A4, INSR
4vanadium4410.1SLC2A4, IRS1, INSR
5phosphoenolpyruvate44 1111.0IRS1, HNF4A, SLC2A4, SLC2A2
6thiazolidinedione4410.0SLC2A4, IRS1, RETN
7sulfonylurea4410.0SLC2A2, ABCC8, SLC2A4, IRS1
8gliclazide44 50 1112.0INSR, SLC2A4, ABCC8
9c-peptide4410.0IRS1, RETN, SLC2A2, INSR, HNF4A
10streptozotocin449.9INSR, IRS1, SLC2A4, SLC2A2
11fructose44 1110.9SLC2A2, SLC2A4, GCGR
12phenylarsine oxide449.9SLC2A4, IRS1, INSR
13glucosamine44 24 1111.9IRS2, IRS1, INSR, SLC2A4
14glimepiride44 50 1111.9ABCC8, SLC2A4, RETN, INSR
15pioglitazone28 44 50 1112.9RETN, SLC2A4, INSR, IRS1
16palmitate449.8IRS1, INSR, SLC2A4, HNF4A
17anisomycin44 1110.8IRS1, SLC2A4, IRS2, INSR
18ibmx44 61 2811.8IRS1, SLC2A4, SLC2A2, INSR
19phosphatidylinositol-3,4,5-trisphosphate44 2410.8SLC2A4, IRS2, IRS1, INSR
20troglitazone44 28 61 1112.8IRS2, IRS1, INSR, SLC2A4
21oligonucleotide449.7SLC2A2, GCGR, HNF1B, AKT2, HNF4A, IRS2
22rosiglitazone28 44 50 24 1113.7INSR, SLC2A4, RETN, IRS2, IRS1
23okadaic acid44 6110.7HNF4A, SLC2A4, IRS2, IRS1
24glycerol44 24 1111.7SLC2A4, HNF4A, INSR, IRS1
25pyruvate449.7SLC2A2, SLC2A4, GPD2, HNF4A
26phosphotyrosine449.7IRS2, IRS1, MAPK8IP1, SLC2A4, INSR
27pd 98,059449.6IRS1, INSR, IRS2, HNF4A, SLC2A4
282-deoxyglucose44 1110.6IRS1, SLC2A4, SLC2A2, PPP1R3A, INSR
29glibenclamide44 28 50 6112.6SLC2A4, INSR, ABCC8
30sterol449.6SLC2A2, HNF4A, HMGA1, SLC2A4, IRS2, IRS1
31arginine449.5IRS1, INSR, SLC2A2, ABCC8, HNF1B, HNF4A
32wortmannin449.5SLC2A4, INSR, IRS1, IRS2, AKT2
33metformin44 50 1111.5INSR, RETN, IRS2, IRS1, ABCC8, SLC2A4
34rapamycin449.5INSR, IRS1, IRS2, HMGA1, SLC2A4, AKT2
35estrogen449.4HNF4A, AKT2, IRS1, HMGA1, IRS2, INSR
36testosterone44 61 24 1112.4HNF4A, INSR, SLC2A4, ABCC8, RETN, IRS1
37dexamethasone44 50 28 1112.4INSR, SLC2A4, HNF4A, IRS1, RETN, IRS2
38alanine449.3SLC2A4, RETN, IRS2, INSR, IRS1, HNF4A
39ly294002449.3SLC2A4, INSR, IRS1, IRS2, AKT2, HMGA1
40fatty acid449.3HMGA1, HNF4A, GCGR, SLC2A4, ABCC8, IRS2
41phosphatidylinositol449.3AKT2, HNF4A, IRS2, IRS1, SLC2A4, RETN
42cycloheximide449.2SLC2A4, RETN, IRS1, IRS2, INSR
43threonine449.1HMGA1, INSR, IRS1, IRS2, SLC2A4, MAPK8IP1
44retinoic acid44 2410.0HMGA1, HNF4A, SLC2A4, HNF1B, IRS2, IRS1
45calcium44 50 24 1111.9HMGA1, HNF4A, MAPK8IP1, RETN, IRS2, GPD2
46serine448.9ABCC8, INSR, HMGA1, HNF4A, SLC2A4, MAPK8IP1
47tyrosine448.9ABCC8, HNF4A, RETN, AKT2, IRS2, IRS1
48lipid448.6PPP1R3A, ABCC8, INSR, IRS1, AKT2, IRS2
49glycogen44 249.5RETN, SLC2A4, SLC2A2, INSR, ABCC8, PPP1R3A
50glucose447.4SLC2A2, GPD2, INSR, PAX4, IRS1, IRS2

GO Terms for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Cellular components related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor complexGO:0058999.7INSR, IRS1
2plasma membraneGO:0058868.5ABCC8, INSR, IRS1, IRS2, AKT2, GCGR

Biological processes related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of plasma membrane long-chain fatty acid transportGO:01074810.3IRS2, AKT2
2positive regulation of glucose import in response to insulin stimulusGO:200127510.2AKT2, IRS1
3positive regulation of glucose metabolic processGO:01090710.1AKT2, IRS2, IRS1
4lipid homeostasisGO:05508810.1IRS2, HNF4A
5regulation of insulin secretionGO:05079610.1SLC2A2, HNF4A, ABCC8
6positive regulation of fatty acid beta-oxidationGO:03200010.1AKT2, IRS2, IRS1
7JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.1IRS2, IRS1
8energy reserve metabolic processGO:00611210.1ABCC8, GCGR, SLC2A2
9response to glucoseGO:00974910.1IRS2, HNF1B, HNF4A, SLC30A8
10regulation of lipid metabolic processGO:01921610.0HNF4A, IRS2
11endocrine pancreas developmentGO:03101810.0PAX4, HNF1B, HNF4A, SLC2A2
12positive regulation of glycogen biosynthetic processGO:0457259.9INSR, IRS1, IRS2, AKT2
13positive regulation of cell migrationGO:0303359.9IRS2, IRS1, INSR
14positive regulation of glucose importGO:0463269.9INSR, IRS1, IRS2, AKT2
15insulin receptor signaling pathwayGO:0082869.8AKT2, IRS2, IRS1, INSR
16mammary gland developmentGO:0308799.8IRS2, IRS1
17carbohydrate metabolic processGO:0059759.6SLC2A2, SLC2A4, INSR, ABCC8
18glucose homeostasisGO:0425939.5SLC30A8, SLC2A4, GCGR, HNF4A, IRS1, INSR
19cellular response to insulin stimulusGO:0328699.5SLC2A4, AKT2, IRS2, IRS1, INSR

Molecular functions related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor bindingGO:00515810.1IRS2, IRS1
2D-glucose transmembrane transporter activityGO:0550569.9SLC2A2, SLC2A4
3phosphatidylinositol 3-kinase bindingGO:0435489.8IRS2, IRS1, INSR
4insulin-like growth factor receptor bindingGO:0051599.7IRS1, INSR

Products for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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  • Antibodies
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Sources for Diabetes Mellitus, Noninsulin-Dependent

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet