Diabetes Mellitus, Noninsulin-Dependent malady

Genetic diseases (common), Endocrine diseases categories

Aliases & Classifications for Diabetes Mellitus, Noninsulin-Dependent

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Aliases & Descriptions for Diabetes Mellitus, Noninsulin-Dependent:

Name: Diabetes Mellitus, Noninsulin-Dependent 46 9 30
Type 2 Diabetes Mellitus 30 8 10
Insulin Resistance 46 44 61
Diabetes Mellitus, Non-Insulin-Dependent 46 61
Type Ii Diabetes Mellitus 8 22
Niddm 8 44
Diabetes Mellitus, Noninsulin-Dependent, Association with 46
Diabetes Mellitus, Noninsulin-Dependent, Late Onset 46
Diabetes Mellitus, Type 2, Susceptiblity to 46
Diabetes Mellitus, Noninsulin-Dependent, 2 46
Hypertension, Insulin Resistance-Related 46
Non-Insulin-Dependent Diabetes Mellitus 8
Diabetes Mellitus, Type Ii 46
Diabetes Mellitus, Type 2 46
Diabetes Mellitus 61
Diabetes, Type 2 46
Diabetes Type 2 32


External Ids:

OMIM46 125853
Disease Ontology8 DOID:9352
MeSH33 D003924
NCIt39 C26747

Summaries for Diabetes Mellitus, Noninsulin-Dependent

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MedlinePlus:32 Diabetes means your blood glucose, or blood sugar, levels are too high. with type 2 diabetes, the more common type, your body does not make or use insulin well. insulin is a hormone that helps glucose get into your cells to give them energy. without insulin, too much glucose stays in your blood. over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth. you have a higher risk of type 2 diabetes if you are older, obese, have a family history of diabetes, or do not exercise. having prediabetes also increases your risk. prediabetes means that your blood sugar is higher than normal but not high enough to be called diabetes. the symptoms of type 2 diabetes appear slowly. some people do not notice symptoms at all. the symptoms can include being very thirsty urinating often feeling very hungry or tired losing weight without trying having sores that heal slowly having blurry eyesight a blood test can show if you have diabetes. many people can manage their diabetes through healthy eating, physical activity, and blood glucose testing. some people also need to take diabetes medicines. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Diabetes Mellitus, Noninsulin-Dependent, also known as type 2 diabetes mellitus, is related to polycystic ovary syndrome and fatty liver disease, and has symptoms including autosomal dominant inheritance, insulin resistance and late onset. An important gene associated with Diabetes Mellitus, Noninsulin-Dependent is SLC30A8 (solute carrier family 30 (zinc transporter), member 8), and among its related pathways are IGF1 pathway and Growth hormone receptor signaling. The drugs chromium picolinate and insulin and the compounds "sulfonamides, urea derivatives" and alloxan have been mentioned in the context of this disorder. Affiliated tissues include kidney, eye and heart, and related mouse phenotypes are pigmentation and liver/biliary system.

Disease Ontology:8 A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.

Description from OMIM:46 125853

Related Diseases for Diabetes Mellitus, Noninsulin-Dependent

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Diseases in the Diabetes Mellitus, Noninsulin-Dependent family:

Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Noninsulin-Dependent, 5
Diabetes Mellitus, Noninsulin-Dependent 1 Kcnj11-Related Susceptibility to Noninsulin-Dependent Diabetes Mellitus

Diseases related to Diabetes Mellitus, Noninsulin-Dependent via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 452)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome32.1PPARG, LIPC, IRS2, RETN
2fatty liver disease31.8RETN, LIPC, PPARG
3glucose intolerance31.7PPARG, IRS2, RETN, GCK, ENPP1
4maturity-onset diabetes of the young31.3GCK, HNF1A, KCNJ11
5uremia31.3ENPP1, RETN, LIPC
6diabetes mellitus, insulin-dependent31.0GCK, HNF1A
7hyperinsulinism31.0PPARG, KCNJ11, IRS2, RETN, GCK
8vascular disease31.0RETN, LIPC, PPARG
9diabetes mellitus, permanent neonatal30.9GCK, KCNJ11
10hyperinsulinemic hypoglycemia30.9KCNJ11, GCK
11hyperglycemia30.9SLC2A2, ENPP1, GCK, GCGR, HNF1A, RETN
12metabolic syndrome x30.8SLC2A2, GCK, RETN, PTPN1, PPARG
13insulinoma30.7KCNJ11, WFS1, HNF1A, GCK, SLC2A2
14hypoglycemia30.6KCNJ11, GCGR, GCK, SLC2A2
15breast cancer30.6PPARG, PTPN1, IRS2, TCF7L2, HNF1A, HMGA1
16colorectal cancer30.5PPARG, IRS2, TCF7L2, TCF4, HNF1A
17coronary artery disease30.5HMGA1, RETN, LIPC
18mody, type ii30.5ENPP1, GCK, HNF1A, RETN, TCF7L2, IRS2
19adenoma30.5HMGA1, HNF1A, TCF7L2, PPARG
20lipid metabolism disorder30.4PPARG, PTPN1, LIPC, TCF7L2, RETN
21hepatocellular carcinoma30.1SLC2A2, HMGA1, HNF1A, TCF4, TCF7L2, LIPC
22atherosclerosis30.0PPARG, PTPN1, LIPC, IRS2, TCF7L2, RETN
23obesity29.8IRS2, LIPC, PTPN1, KCNJ11, PPARG, RETN
25liver disease11.0
27hepatitis c10.9
29peripheral neuropathy10.8
31diabetes mellitus, noninsulin-dependent, 210.7
32diabetes mellitus, noninsulin-dependent 110.7
33hepatitis c virus10.7
34diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension10.7
35insulin-like growth factor i10.7
36morbid obesity10.6
37nonalcoholic steatohepatitis10.6
39diabetes mellitus, noninsulin-dependent, 510.6
41peripheral vascular disease10.6
44rheumatoid arthritis10.6
46rabson-mendenhall syndrome10.5
47pitt-hopkins syndrome10.5TCF4
48ovarian disease10.5
49hepatic lipase deficiency10.5LIPC
50renal cysts and diabetes syndrome10.5

Graphical network of the top 20 diseases related to Diabetes Mellitus, Noninsulin-Dependent:

Diseases related to diabetes mellitus, noninsulin-dependent

Symptoms for Diabetes Mellitus, Noninsulin-Dependent

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Symptoms by clinical synopsis from OMIM:


Clinical features from OMIM:


HPO human phenotypes related to Diabetes Mellitus, Noninsulin-Dependent:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 insulin resistance HP:0000855
3 late onset HP:0003584
4 type ii diabetes mellitus HP:0005978

Drugs & Therapeutics for Diabetes Mellitus, Noninsulin-Dependent

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Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus, Noninsulin-Dependent

Search NIH Clinical Center for Diabetes Mellitus, Noninsulin-Dependent

Inferred drug relations via UMLS61/NDF-RT40:

Show with subtypes

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Genetic Tests for Diabetes Mellitus, Noninsulin-Dependent

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Genetic tests related to Diabetes Mellitus, Noninsulin-Dependent:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 222

Anatomical Context for Diabetes Mellitus, Noninsulin-Dependent

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MalaCards organs/tissues related to Diabetes Mellitus, Noninsulin-Dependent:

Kidney, Eye, Heart, Testes, Bone, Thyroid, T cells

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Diabetes Mellitus, Noninsulin-Dependent:
id TissueAnatomical CompartmentCell Relevance
1 PancreasIslets of LangerhansMature Beta Cells Potential therapeutic candidate, affected by disease
2 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Diabetes Mellitus, Noninsulin-Dependent or affiliated genes

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MGI Mouse Phenotypes related to Diabetes Mellitus, Noninsulin-Dependent:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.7SLC30A8, IRS2, LIPH, KCNJ11
2MP:00053709.0PPARG, TCF7L2, RETN, HNF1A, GCK, ENPP1
3MP:00107718.9PPARG, KCNJ11, LIPH, IRS2, TCF7L2, WFS1
4MP:00053758.8PPARG, KCNJ11, PTPN1, IRS2, TCF7L2, RETN
5MP:00053698.6PPARG, KCNJ11, IRS2, TCF7L2, HNF1A, ENPP1
6MP:00053868.3PPARG, KCNJ11, PTPN1, IRS2, TCF7L2, WFS1
7MP:00107688.1TCF7L2, IRS2, PTPN1, KCNJ11, PPARG, TCF4
8MP:00053798.1SLC30A8, PPARG, KCNJ11, PTPN1, LIPC, IRS2
9MP:00053787.9TCF4, TCF7L2, IRS2, PTPN1, KCNJ11, PPARG
10MP:00053767.8RETN, TCF7L2, IRS2, LIPC, PTPN1, KCNJ11

Publications for Diabetes Mellitus, Noninsulin-Dependent

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Variations for Diabetes Mellitus, Noninsulin-Dependent

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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent:

63 (show all 11)
id Symbol AA change Variation ID SNP ID

Clinvar genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent:

5 (show all 32)
id Gene Variation Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
3ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
4PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
5AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
6SLC30A8NM_173851.2(SLC30A8): c.412C> T (p.Arg138Ter)single nucleotide variantprotectivers200185429GRCh37Chr 8, 118165323: 118165323
7SLC30A8NM_173851.2(SLC30A8): c.101_107delAAGATCA (p.Lys34Serfs)deletionprotectiveGRCh37Chr 8, 118159222: 118159228
8LIPCLIPC, -250G-Asingle nucleotide variantrisk factor
9INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
10INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenic, Pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
11IL6IL6, -174G-Csingle nucleotide variantrisk factor
12GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
13SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
14GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
15IGF2BP2NM_006548.4(IGF2BP2): c.239+29254C> Asingle nucleotide variantrisk factorrs4402960GRCh37Chr 3, 185511687: 185511687
16IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
17IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
18HMGA1HMGA1, 1-BP INS, IVS5, -13insertionrisk factor
19RETNRETN, +62G-Asingle nucleotide variantrisk factor
20CAPN10NM_023083.3(CAPN10): c.471-176G> Asingle nucleotide variantrisk factorrs3792267GRCh37Chr 2, 241531174: 241531174
21CAPN10CAPN10, IVS6, INS/DEL, 39-BPindelrisk factor
22CAPN10CAPN10, IVS13, g.16378G-Tsingle nucleotide variantrisk factor
23CAPN10CAPN10, IVS3, g.4841T-Csingle nucleotide variantrisk factor
24MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
25TCF7L2NM_030756.4(TCF7L2): c.382-41435C> Tsingle nucleotide variantrisk factorrs7903146GRCh37Chr 10, 114758349: 114758349
26TCF7L2NM_030756.4(TCF7L2): c.483+9017G> Tsingle nucleotide variantrisk factorrs12255372GRCh37Chr 10, 114808902: 114808902
27TCF7L2NM_030756.4(TCF7L2): c.483+7162G> Csingle nucleotide variantrisk factorrs11196205GRCh37Chr 10, 114807047: 114807047
28NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
29KCNJ11NM_000525.3(KCNJ11): c.67A> G (p.Lys23Glu)single nucleotide variantdrug response, risk factorrs5219GRCh37Chr 11, 17409572: 17409572
30ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
31ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
32HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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LifeMap Discovery
Genes differentially expressed in tissues of Diabetes Mellitus, Noninsulin-Dependent patients vs. healthy controls: 30 (show all 49)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1E2F8E2F transcription factor 8Blood+3.490.000
2KDM5Dlysine (K)-specific demethylase 5DBlood+3.490.028
3RPS4Y1ribosomal protein S4, Y-linked 1Blood+3.480.048
4CCNB1cyclin B1Blood+3.450.000
5SEC61A1Sec61 alpha 1 subunit (S. cerevisiae)Blood+3.420.000
6E2F7E2F transcription factor 7Blood+3.410.000
7HJURPHolliday junction recognition proteinBlood+3.400.000
8IGLV1-44immunoglobulin lambda variable 1-44Blood+3.380.000
9NCOA3nuclear receptor coactivator 3Blood+3.370.000
10KIF18Bkinesin family member 18BBlood+3.360.000
11ELL2elongation factor, RNA polymerase II, 2Blood+3.360.000
12SLC16A14solute carrier family 16, member 14Blood+3.350.001
13KIF20Akinesin family member 20ABlood+3.320.000
14TPX2TPX2, microtubule-associatedBlood+3.320.000
15ITM2Cintegral membrane protein 2CBlood+3.310.000
16UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)Blood+3.310.000
17TRIP13thyroid hormone receptor interactor 13Blood+3.300.000
18KIF15kinesin family member 15Blood+3.280.000
19AURKBaurora kinase BBlood+3.270.000
20KIF4Akinesin family member 4ABlood+3.260.000
21GTSE1G-2 and S-phase expressed 1Blood+3.260.000
22CDCA5cell division cycle associated 5Blood+3.250.000
23ESPL1extra spindle pole bodies homolog 1 (S. cerevisiae)Blood+3.240.000
24GINS1GINS complex subunit 1 (Psf1 homolog)Blood+3.230.000
25ANLNanillin, actin binding proteinBlood+3.230.000
26PKHD1L1polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1Blood+3.210.000
27RAD51AP1RAD51 associated protein 1Blood+3.200.000
28KLHL14kelch-like family member 14Blood+3.190.000
29CCND2cyclin D2Blood+3.170.000
30MANEAmannosidase, endo-alphaBlood+3.170.000
31ALDH1L2aldehyde dehydrogenase 1 family, member L2Blood+3.160.000
32SEC24ASEC24 family member ABlood+3.160.000
33FOXM1forkhead box M1Blood+3.150.000
34IGKV1D-13immunoglobulin kappa variable 1D-13Blood+3.150.000
35RAD51RAD51 recombinaseBlood+3.140.000
36IGLV4-60immunoglobulin lambda variable 4-60Blood+3.140.000
37OIP5Opa interacting protein 5Blood+3.130.000
38IGF1insulin-like growth factor 1 (somatomedin C)Blood+3.130.000
39DERL3derlin 3Blood+3.120.000
40DENND5BDENN/MADD domain containing 5BBlood+3.110.001
41MCM4minichromosome maintenance complex component 4Blood+3.100.000
42LAMC1laminin, gamma 1 (formerly LAMB2)Blood+3.090.000
43KCTD14potassium channel tetramerization domain containing 14Blood+3.090.000
44NUSAP1nucleolar and spindle associated protein 1Blood+3.080.000
45KIF14kinesin family member 14Blood+3.080.000
46C19orf10chromosome 19 open reading frame 10Blood+3.080.000
47SEL1L3sel-1 suppressor of lin-12-like 3 (C. elegans)Blood+3.020.000
48IGLV6-57immunoglobulin lambda variable 6-57Blood+3.010.000
49DEPDC1DEP domain containing 1Blood+3.010.000

Search GEO for disease gene expression data for Diabetes Mellitus, Noninsulin-Dependent.

Pathways for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Pathways related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IRS2, PTPN1
210.0IRS2, PTPN1
310.0TCF7L2, PPARG
49.9PTPN1, IRS2, ENPP1
Show member pathways
Show member pathways
79.8KCNJ11, PTPN1, IRS2
Show member pathways
9.7SLC2A2, GCK, KCNJ11
Show member pathways
109.6KCNJ11, HNF1A, GCK, SLC2A2
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling59
Leptin signaling pathway36
Show member pathways
Show member pathways
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Compounds for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Compounds related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1sulfonamides, urea derivatives5010.4TCF7L2, KCNJ11
2alloxan4410.4SLC2A2, GCK
3Alpha-D-Glucose2410.4ENPP1, GCK
4tolbutamide44 28 50 1113.3KCNJ11, HNF1A, GCK
53-o-methylglucose4410.3SLC2A2, GCK
6incretin4410.3GCGR, GCK, SLC2A2
7preproinsulin4410.3SLC2A2, GCK
8mononucleotide4410.3TCF4, TCF7L2
9proglucagon4410.2SLC2A2, GCK, TCF7L2
10phosphoenolpyruvate44 1111.2HNF1A, GCK, SLC2A2
11glimepiride44 50 1112.1PPARG, KCNJ11, RETN
12katp4410.1SLC2A2, GCK, KCNJ11
13fenofibrate44 50 1112.1RETN, LIPC, PPARG
14fructose44 1111.1PTPN1, GCGR, GCK, SLC2A2
15atorvastatin44 50 28 24 1114.0HMGA1, RETN, LIPC, PPARG
16sulfonylurea4410.0SLC2A2, GCK, HNF1A, KCNJ11
17repaglinide50 44 1112.0PPARG, KCNJ11, TCF7L2, SLC30A8
182-deoxyglucose44 1111.0SLC2A2, GCK, PPARG
19rapamycin4410.0PPARG, IRS2, HMGA1, ENPP1
20pyruvate4410.0PTPN1, HNF1A, GCK, SLC2A2
21rosiglitazone28 44 50 24 1114.0PPARG, PTPN1, IRS2, RETN
22pioglitazone28 44 50 1113.0PPARG, PTPN1, LIPC, RETN
23thyroxine44 2410.9PPARG, LIPC, RETN
24potassium44 24 1111.8KCNJ11, HNF1A, GCK, SLC2A2
25threonine449.8PTPN1, LIPC, IRS2, HMGA1, GCK, ENPP1
26dexamethasone44 50 28 1112.8PPARG, IRS2, RETN, HNF1A, GCK, ENPP1
27phosphatidylinositol449.8ENPP1, RETN, TCF7L2, IRS2, PTPN1
28ly294002449.8PPARG, IRS2, TCF7L2, RETN, HMGA1, GCK
29nitric oxide44 24 1111.8PTPN1, IRS2, TCF7L2, RETN, GCK
30oligonucleotide449.7PTPN1, IRS2, HNF1A, GCGR, GCK, SLC2A2
31glutamine449.7PPARG, KCNJ11, PTPN1, HNF1A, GCK, ENPP1
32c-peptide449.7KCNJ11, LIPC, RETN, HNF1A, GCK, SLC2A2
33testosterone44 60 24 1112.7PPARG, PTPN1, LIPC, TCF7L2, RETN
34alanine449.6PPARG, PTPN1, IRS2, RETN, GCK
35cholesterol44 28 24 1112.6PPARG, PTPN1, LIPC, RETN, HNF1A, HMGA1
36tyrosine449.6PTPN1, LIPC, IRS2, RETN, HNF1A, HMGA1
37oxygen44 2410.6GCK, RETN, IRS2, LIPC, PTPN1
38arginine449.5KCNJ11, PTPN1, LIPC, HMGA1, GCK, SLC2A2
39leucine449.5KCNJ11, HNF1A, GCK, SLC2A2
40metformin44 50 1111.5PPARG, KCNJ11, PTPN1, IRS2, RETN, GCK
41estrogen449.5PPARG, PTPN1, LIPC, IRS2, RETN, HNF1A
42serine449.5ENPP1, GCK, HMGA1, IRS2, LIPC, PTPN1
43atp44 2810.4KCNJ11, PTPN1, LIPC, GCGR, GCK, ENPP1
44fatty acid449.4PPARG, LIPC, IRS2, RETN, HNF1A, HMGA1
45retinoic acid44 2410.3PPARG, IRS2, HNF1A, HMGA1, GCK
46calcium44 50 24 1112.2KCNJ11, PTPN1, LIPC, IRS2, RETN, WFS1
47sterol449.1SLC2A2, GCK, HMGA1, HNF1A, RETN, IRS2
48glycogen44 2410.1TCF7L2, IRS2, LIPC, PTPN1, TCF4, RETN
49lipid448.9PPARG, PTPN1, LIPH, LIPC, IRS2, TCF7L2
50glucose448.2SLC2A2, PPARG, KCNJ11, PTPN1, ENPP1, GCK

GO Terms for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent

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Cellular components related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058298.9IGF2BP2, KCNJ11, PTPN1, IRS2, HMGA1, GCK
2plasma membraneGO:00058868.4SLC30A8, KCNJ11, PTPN1, LIPH, IRS2, MTNR1B

Biological processes related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of type B pancreatic cell apoptotic processGO:0200067510.4WFS1, TCF7L2
2positive regulation of glycogen biosynthetic processGO:004572510.3GCK, IRS2
3neurological system processGO:005087710.2WFS1, KCNJ11
4insulin secretionGO:003007310.2SLC30A8, HNF1A
5response to glucoseGO:000974910.2IRS2, TCF7L2, SLC30A8
6positive regulation of insulin secretionGO:003202410.2IRS2, TCF7L2, GCK, SLC30A8
7negative regulation of insulin receptor signaling pathwayGO:004662710.1PTPN1, ENPP1
8lipid homeostasisGO:005508810.0IRS2, PPARG
9cellular response to insulin stimulusGO:003286910.0ENPP1, GCK, IRS2, PPARG
10JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.9IRS2, PTPN1
11energy reserve metabolic processGO:00061129.9KCNJ11, GCGR, SLC2A2
12regulation of insulin secretionGO:00507969.8KCNJ11, MTNR1B, GCK, SLC2A2
13glucose homeostasisGO:00425939.5SLC30A8, PPARG, TCF7L2, MTNR1B, WFS1, HNF1A
14positive regulation of transcription, DNA-templatedGO:00458939.4HMGA1, HNF1A, TCF4, PPARG

Molecular functions related to Diabetes Mellitus, Noninsulin-Dependent according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1phospholipase activityGO:000462010.2LIPC, LIPH
2insulin receptor bindingGO:000515810.1ENPP1, IRS2, PTPN1
3retinoid X receptor bindingGO:004696510.0HMGA1, PPARG
4activating transcription factor bindingGO:00336139.9PPARG, WFS1
5transcription regulatory region DNA bindingGO:00442129.5HNF1A, TCF7L2, PPARG
6sequence-specific DNA binding transcription factor activityGO:00037009.5HMGA1, HNF1A, TCF4, TCF7L2, PPARG
7protein bindingGO:00055158.5IRS2, PTPN1, IGF2BP2, PPARG, TCF7L2, TCF4

Sources for Diabetes Mellitus, Noninsulin-Dependent

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26ICD10 via Orphanet
34MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
62UMLS via Orphanet