MCID: DBT026
MIFTS: 80

Diabetes Mellitus, Noninsulin-Dependent

Categories: Genetic diseases, Endocrine diseases, Metabolic diseases

Aliases & Classifications for Diabetes Mellitus, Noninsulin-Dependent

MalaCards integrated aliases for Diabetes Mellitus, Noninsulin-Dependent:

Name: Diabetes Mellitus, Noninsulin-Dependent 54 24 13 38
Insulin Resistance 54 29 52 69
Diabetes Mellitus, Non-Insulin-Dependent 54 71 69
Type 2 Diabetes Mellitus 38 12 14
Niddm 12 71 52
Diabetes Mellitus, Type 2 54 42
Diabetes Mellitus Type 2 71 29
Diabetes Mellitus, Noninsulin-Dependent, Association with 54
Diabetes Mellitus, Noninsulin-Dependent, Late Onset 54
Diabetes Mellitus, Noninsulin-Dependent, 2 54
Hypertension, Insulin Resistance-Related 54
Non-Insulin-Dependent Diabetes Mellitus 12
Noninsulin-Dependent Diabetes Mellitus 71
Insulin Resistance, Severe, Digenic 54
Adult-Onset Diabetes Mellitus 71
Diabetes Mellitus, Type Ii 54
Type Ii Diabetes Mellitus 12
Diabetes Mellitus Type Ii 71
Maturity-Onset Diabetes 71
Diabetes Mellitus 69
Diabetes, Type 2 54
Diabetes Type 2 41
T2d 71

Characteristics:

OMIM:

54
Inheritance:
autosomal dominant


HPO:

32
diabetes mellitus, noninsulin-dependent:
Onset and clinical course late onset
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Diabetes Mellitus, Noninsulin-Dependent

MedlinePlus : 41 diabetes means your blood glucose, or blood sugar, levels are too high. with type 2 diabetes, the more common type, your body does not make or use insulin well. insulin is a hormone that helps glucose get into your cells to give them energy. without insulin, too much glucose stays in your blood. over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth. you have a higher risk of type 2 diabetes if you are older, obese, have a family history of diabetes, or do not exercise. having prediabetes also increases your risk. prediabetes means that your blood sugar is higher than normal but not high enough to be called diabetes. the symptoms of type 2 diabetes appear slowly. some people do not notice symptoms at all. the symptoms can include being very thirsty urinating often feeling very hungry or tired losing weight without trying having sores that heal slowly having blurry eyesight blood tests can show if you have diabetes. one type of test, the a1c, can also check on how you are managing your diabetes. many people can manage their diabetes through healthy eating, physical activity, and blood glucose testing. some people also need to take diabetes medicines. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Diabetes Mellitus, Noninsulin-Dependent, also known as insulin resistance, is related to diabetes mellitus, permanent neonatal and diabetes mellitus, transient neonatal, 3, and has symptoms including insulin resistance, type ii diabetes mellitus and angina pectoris. An important gene associated with Diabetes Mellitus, Noninsulin-Dependent is NEUROD1 (Neuronal Differentiation 1), and among its related pathways/superpathways are Type II diabetes mellitus and Developmental Biology. The drugs Linagliptin and Metformin have been mentioned in the context of this disorder. Affiliated tissues include Pancreas and Adipose, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

UniProtKB/Swiss-Prot : 71 Diabetes mellitus, non-insulin-dependent: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Disease Ontology : 12 A diabetes mellitus that involves high blood glucose resulting from cells fail to use insulin properly.

Wikipedia : 72 Diabetes mellitus... more...

Description from OMIM: 125853

Related Diseases for Diabetes Mellitus, Noninsulin-Dependent

Diseases in the Diabetes Mellitus, Noninsulin-Dependent family:

Diabetes Mellitus, Noninsulin-Dependent 1 Diabetes Mellitus, Noninsulin-Dependent, 2
Diabetes Mellitus, Noninsulin-Dependent, 5 Kcnj11-Related Susceptibility to Noninsulin-Dependent Diabetes Mellitus

Diseases related to Diabetes Mellitus, Noninsulin-Dependent via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
id Related Disease Score Top Affiliating Genes
1 diabetes mellitus, permanent neonatal 33.2 ABCC8 GCK
2 diabetes mellitus, transient neonatal, 3 32.7 ABCC8 HNF4A
3 insulin-resistant acanthosis nigricans, type a 12.4
4 diabetes mellitus, noninsulin-dependent 1 12.4
5 diabetes mellitus, noninsulin-dependent, 2 12.4
6 diabetes mellitus, noninsulin-dependent, 5 12.3
7 diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension 12.3
8 diabetes mellitus, insulin-resistant, with acanthosis nigricans 12.3
9 kcnj11-related susceptibility to noninsulin-dependent diabetes mellitus 12.3
10 insulin-resistance type b 12.2
11 maturity-onset diabetes of the young 6 12.0 ABCC8 AKT2 ENPP1 GCGR GCK GPD2
12 rabson-mendenhall syndrome 11.9
13 hair-an syndrome 11.9
14 short fifth metacarpals-insulin resistance syndrome 11.9
15 severe early-onset obesity-insulin resistance syndrome due to sh2b1 deficiency 11.9
16 microcephalic primordial dwarfism-insulin resistance syndrome 11.9
17 hepatic adenoma, somatic 11.7 ABCC8 GCK HNF1B HNF4A INSR IRS1
18 short syndrome 11.7
19 congenital stationary night blindness 11.6 ABCC8 GCK HNF1B HNF4A IRS1 NEUROD1
20 hypertrichosis 11.5 ABCC8 GCK IRS1 RETN SLC30A8 TCF7L2
21 peroneal neuropathy 11.5 ABCC8 GCGR GCK INSR IRS1 PDX1
22 von hippel-lindau syndrome 11.4 ABCC8 ENPP1 GCK INSR IRS1 LIPC
23 morning glory syndrome 11.4 ABCC8 GCK HNF1B HNF4A PDX1
24 distal muscular dystrophy 11.4 ABCC8 GCK HNF1B NEUROD1 PDX1
25 short bowel syndrome 11.4 ENPP1 GCK INSR IRS1 RETN
26 intraocular lymphoma 11.4 ABCC8 GCK NEUROD1 PDX1 WFS1
27 antidepressant type abuse 11.4 GCK INSR IRS1 RETN TCF7L2
28 diabetic cataract 11.3 ABCC8 GCK HNF4A INSR
29 lipodystrophy, familial partial, type 3 11.3
30 exostosis 11.3 ABCC8 GCK HNF4A INSR
31 triple x syndrome 11.3 ABCC8 AKT2 GCK INSR
32 inclusion body myopathy with paget disease of bone and frontotemporal dementia 11.2 ABCC8 GCK PDX1
33 maturity-onset diabetes of the young 11.2
34 neurogenic arthropathy 11.2 ABCC8 GCK IRS1
35 prader-willi syndrome 11.2
36 familial papillary thyroid carcinoma 11.2 ABCC8 HNF4A
37 spinal and bulbar muscular atrophy of kennedy 11.2
38 werner syndrome 11.2
39 palmoplantar keratoderma and woolly hair 11.2 ABCC8 INSR
40 diabetes and deafness, maternally inherited 11.2
41 diaphanospondylodysostosis 11.2 ABCC8 GCK PDX1
42 writing disorder 11.1 ABCC8 GCK
43 prostate cancer, hereditary, 11 11.1 HNF1B HNF4A
44 survival motor neuron spinal muscular atrophy 11.1 GCK IRS1 RETN
45 hyperchylomicronemia, late-onset 11.0 ENPP1 INSR LIPC
46 autoimmune polyendocrine syndrome, type ii 11.0
47 mody, type ii 11.0
48 morbid obesity and spermatogenic failure 11.0
49 diabetes mellitus, transient neonatal, 1 11.0
50 hemoglobin zurich 10.9 ABCC8 AKT2

Graphical network of the top 20 diseases related to Diabetes Mellitus, Noninsulin-Dependent:



Diseases related to Diabetes Mellitus, Noninsulin-Dependent

Symptoms & Phenotypes for Diabetes Mellitus, Noninsulin-Dependent

Symptoms via clinical synopsis from OMIM:

54

Endo:
noninsulin-dependent diabetes mellitus

Lab:
insulin resistance
decreased glucose disposal

Misc:
late onset


Clinical features from OMIM:

125853

Human phenotypes related to Diabetes Mellitus, Noninsulin-Dependent:

32
id Description HPO Frequency HPO Source Accession
1 insulin resistance 32 HP:0000855
2 type ii diabetes mellitus 32 HP:0005978

UMLS symptoms related to Diabetes Mellitus, Noninsulin-Dependent:


angina pectoris, tremor, equilibration disorder, symptoms

MGI Mouse Phenotypes related to Diabetes Mellitus, Noninsulin-Dependent:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.32 PAX4 PDX1 PPP1R3A RETN SLC30A8 TCF7L2
2 endocrine/exocrine gland MP:0005379 10.31 IRS1 LIPC MAPK8IP1 NEUROD1 PAX4 PDX1
3 growth/size/body region MP:0005378 10.3 AKT2 ENPP1 GCGR GCK GPD2 HNF1B
4 liver/biliary system MP:0005370 10.1 AKT2 ENPP1 GCGR GCK GPD2 HNF1B
5 adipose tissue MP:0005375 10.09 GCGR GPD2 INSR IRS1 PPP1R3A RETN
6 mortality/aging MP:0010768 10.03 AKT2 ENPP1 GCGR GCK GPD2 HNF1B
7 muscle MP:0005369 9.56 TCF7L2 AKT2 ENPP1 HNF1B INSR IRS1
8 renal/urinary system MP:0005367 9.1 ENPP1 GCK HNF1B INSR NEUROD1 PDX1

Drugs & Therapeutics for Diabetes Mellitus, Noninsulin-Dependent

Drugs for Diabetes Mellitus, Noninsulin-Dependent (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 938)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Linagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 668270-12-0 10096344
2
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
3
Voglibose Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83480-29-9 444020
4
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1 204656-20-2 44147092
5
Orlistat Approved, Investigational Phase 4,Phase 2 96829-58-2 3034010
6
Insulin Glargine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 160337-95-1
7
Zinc Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 7440-66-6 32051 23994
8
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 111025-46-8 4829
9
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 141758-74-9 15991534
10
Glipizide Approved Phase 4,Phase 3,Phase 2,Phase 1 29094-61-9 3478
11
Saxagliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 361442-04-8 11243969
12
Acarbose Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 56180-94-0 441184
13
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
14
Insulin Lispro Approved Phase 4,Phase 3,Phase 2,Phase 1 133107-64-9
15
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 116094-23-6 16132418
16
Insulin Detemir Approved Phase 4,Phase 3,Phase 2,Phase 1 169148-63-4 5311023
17
Glimepiride Approved Phase 4,Phase 3,Phase 2,Phase 1 93479-97-1 3476
18
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 2,Phase 3 128-13-2 31401
19
Fluvastatin Approved Phase 4,Phase 3 93957-54-1 1548972
20
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137862-53-4 60846
21
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
22
Insulin-glulisine Approved Phase 4,Phase 3,Phase 2,Phase 1 207748-29-6
23
Ramipril Approved Phase 4,Phase 3,Early Phase 1 87333-19-5 5362129
24
Ticlopidine Approved Phase 4,Phase 2 55142-85-3 5472
25
Alogliptin Approved Phase 4,Phase 3,Phase 2,Phase 1 850649-61-5 11450633
26
Zaleplon Approved, Illicit, Investigational Phase 4 151319-34-5 5719
27
Amlodipine Approved Phase 4,Phase 3,Phase 1 88150-42-9 2162
28
Atenolol Approved Phase 4 29122-68-7 2249
29
Clonidine Approved Phase 4,Phase 3 4205-90-7 2803
30
Doxazosin Approved Phase 4 74191-85-8 3157
31
Furosemide Approved, Vet_approved Phase 4,Phase 1 54-31-9 3440
32
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-93-5 3639
33
Irbesartan Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 138402-11-6 3749
34
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 79902-63-9 54454
35
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2 75847-73-3 5362032 40466924
36
Enalaprilat Approved Phase 4,Phase 3,Phase 2 76420-72-9 6917719
37
Gliclazide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 21187-98-4 3475
38
Repaglinide Approved, Investigational Phase 4,Phase 3,Phase 2 135062-02-1 65981
39
Isosorbide Dinitrate Approved Phase 4 87-33-2 6883
40
Nitric Oxide Approved Phase 4,Phase 2,Phase 3 10102-43-9 145068
41
Glyburide Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 10238-21-8 3488
42
Vildagliptin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 274901-16-5 6918537
43
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-18-4 6010
44
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
45
Cilostazol Approved Phase 4,Phase 3 73963-72-1 2754
46
Oxymetazoline Approved Phase 4,Phase 1 1491-59-4 4636
47
Phenylephrine Approved Phase 4,Phase 1 59-42-7 6041
48
Fenofibrate Approved Phase 4,Phase 3,Phase 2 49562-28-9 3339
49
Thrombin Approved Phase 4
50
Candesartan Approved Phase 4,Phase 3,Phase 2 139481-59-7 2541

Interventional clinical trials:

(show top 50) (show all 6788)

id Name Status NCT ID Phase Drugs
1 Effect of Linagliptin on Insulin Sensitivity and Pancreatic Beta Cell Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02097342 Phase 4 Linagliptin;Placebo;Voglibose
2 Bone Turnover in Type 2 Diabetes Patients Unknown status NCT00732121 Phase 4 Sitagliptin;Placebo
3 Continuous Glucose Monitoring in Patients With Type 2 Diabetes Unknown status NCT00529815 Phase 4
4 Combinatorial Therapy for Peristent Type 2 Diabetes After Gastric Banding Unknown status NCT01597531 Phase 4 Liraglutide;Orlistat;Liraglutide + Orlistat
5 Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD) Unknown status NCT01035528 Phase 4 insulin glargine;metformin
6 Multifactorial Intervention in Type 2 Diabetes - Italy Unknown status NCT01240070 Phase 4
7 Comparison of the Efficacy and Safety Between Pioglitazone and Placebo Added to Combination Therapy in Type 2 Diabetes Unknown status NCT00991055 Phase 4 Pioglitazone
8 Study of Comparison the Treatment Effect Between Gastric Bypass and Exenatide in Type 2 Diabetes Unknown status NCT01435980 Phase 4 Exenatide
9 Outpatient Discharge Therapy With Saxagliptin+MetforminXR vs GlipizideXL for Type 2 Diabetes With Severe Hyperglycemia Unknown status NCT01267448 Phase 4 Glipizide XL;Saxagliptin + Metformin XR;Metformin XR
10 Efficacy of Acarbose on Intestinal Microbiome and Incretins of Type 2 Diabetes Unknown status NCT01758471 Phase 4 Glipizide;Acarbose
11 Prevalence of Macrovascular Disease in Type 2 Diabetes Mellitus Unknown status NCT00298844 Phase 4
12 Type 2 Diabetes Mellitus and Atherosclerosis Unknown status NCT01250340 Phase 4 Aspirin;Placebo
13 Metformin and Sitagliptin Therapy for Adult Patients With Type 2 Diabetes Admitted to the General Medical Unit Unknown status NCT02250794 Phase 4 metformin and sitagliptin;insulin glargine and insulin lispro;metformin and sitagliptin;insulin glargine and insulin lispro
14 Comparison of Cardiovascular Outcomes of Pioglitazone and Metformin in Type 2 Diabetes Patients Unknown status NCT00399204 Phase 4 Pioglitazone vs Metformin
15 Insulin Effects on Metabolism and Cardiovascular Function in Type 2 Diabetes Unknown status NCT00747409 Phase 4 insulin aspart and detemir (NovoRapid, Levemir);human regular insulin and NPH insulin (Actrapid, Protaphne)
16 Clinical Study to Compare Various Dosing and Titration Guidelines of Insulin Delivered Via V-Go ® in Patients With Type 2 Diabetes Initiating Basal Bolus Therapy in Primary Care Offices Unknown status NCT02361489 Phase 4
17 The Efficacy of Glucerna SR in Chinese Drug-naïve Subjects With Type 2 Diabetes Unknown status NCT02248714 Phase 4
18 Mechanistic Study of the Systolic Blood Pressure Lowering Effect of Dapagliflozin in Type 2 Diabetes Unknown status NCT02372955 Phase 4 dapagliflozin;glimpiride
19 The INDORSE Study: Inhibition of Dipeptidyl Peptidase IV: Outcomes on Renal Sodium Excretion Unknown status NCT02406443 Phase 4 Sitaglitpin
20 Efficacy and Safety of Ursodeoxycholic Acid (UDCA) Added to the DPP-4 Inhibitor in People With Type 2 Diabetes and Chronic Liver Diseases Unknown status NCT01337440 Phase 4 UDCA;Sitagliptin
21 the Effect of Vitamin D on the Serum Thioredoxin, TBP-2, Thioredoxin Reductase, Gene Expression of TBP-2 in Patients With Type II Diabetes Unknown status NCT01876563 Phase 4
22 Prospective Randomized Trials of Gastric Bypass Surgery in Patients With Type II Diabetes Mellitus Unknown status NCT00540462 Phase 4
23 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
24 Intensive Medical Treatment for Nephropathy Caused by Type 2 Diabetes With Hypertension Unknown status NCT00407680 Phase 4 Intensive therapy Valsartan,Fluvastatin
25 The Impact of Omega-3 Supplementation on Gene Expression in Type 2 Diabetics Unknown status NCT01478776 Phase 4
26 German Diabetes-Diet-Intervention and Energy Restriction-Trial (DDIET) Unknown status NCT01409330 Phase 4
27 Glucagon Like Peptides Receptors Expression in the Stomach of Diabetes Type 2 Unknown status NCT00473733 Phase 4
28 Various Insulin Regimens for Diabetic Inpatients With Cirrhosis Trial Unknown status NCT01143948 Phase 4 Glargine & Glulisine;Regular insulin;NPH & regular insulin
29 Ramipril and Clopidogrel in Oxidative Stress, Vascular Inflammation and Endothelial Dysfunction in Type 2 Diabetes and Diabetic Nephropathy Unknown status NCT01743014 Phase 4 Ramipril;Clopidogrel
30 Effect of Linagliptin in Comparison With Glimepiride as Add on to Metformin on Postprandial Beta Cell Function, Postprandial Metabolism and Oxidative Stress in Patients With Type 2 Diabetes Mellitus Unknown status NCT01547104 Phase 4 Linagliptin;Glimepiride
31 Comparison of Pioglitazone Versus Glimepiride in Type 2 Diabetes Inadequately Controlled With Metformin Plus Alogliptin Unknown status NCT02426294 Phase 4 Pioglitazone;Glimepiride
32 Safety of Add on Aliskiren to Angiotensin Converting Enzyme Inhibitor (ACEI) and Angiotensin I Receptor Blocker (ARB) Treatment in Type 2 Diabetes With Nephropathy Unknown status NCT00949351 Phase 4 Aliskiren 300mg/d
33 Effect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy Unknown status NCT02129985 Phase 4 Exenatide;Metformin
34 Exploratory Study to Compare the Effects of Tenelia® or Januvia® on Glucose Variability in add-on to Metformin (CGMS Study) Unknown status NCT02512523 Phase 4 Teneligliptin;Sitagliptin
35 Treatment With Continuous Sub-cutaneous Insulin Infusion Via a Portable Pump Versus Discontinuous Insulin Infusion Via Multiple-injections in Type 2 Diabetes Unknown status NCT02048189 Phase 4 LEVEMIR;APIDRA
36 Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes Unknown status NCT01978405 Phase 4 Alpha lipoic acid
37 Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT) Unknown status NCT00915954 Phase 4
38 Prospective Influence of Bedtime Insulin Glargine on Mobilization and Function of Endothelial Progenitor Cells Unknown status NCT00523393 Phase 4 Insulin Glargin;Human Insulin
39 the Efficacy of Acarbose and Metformin on Blood Glucose Fluctuation When Combined With Premix Insulin Unknown status NCT02438397 Phase 4 premix insulin;metformin;Acarbose
40 Effects of Valsartan and Aliskiren on Hemostatic Indices in Hypertensive Diabetics Unknown status NCT01095822 Phase 4 Aliskiren + Valsartan
41 Effect of Sarpogrelate On the Nephropathy in Type 2 Diabetes (SONATA Study) Unknown status NCT01869881 Phase 4 Anplag(Sarpogrelate);Placebo
42 The Effects of Vitamin D Supplementation on Patients With Type 2 Diabetes and Vitamin D Deficiency Unknown status NCT01991054 Phase 4
43 Nephropathy In Type 2 Diabetes and Cardio-renal Events Unknown status NCT00535925 Phase 4 current therapy;irbesartan;ramipril;hydrochlorothiazide;furosemide;amlodipine;atenolol;doxazosin;clonidine;insulin;simvastatin;fibrate;erythropoietin;aspirin
44 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
45 Aspirin and Enalapril in Microalbuminuric Type 2 Diabetes Mellitus Patients Unknown status NCT00427271 Phase 4 aspirin
46 Comparison of Glycaemic Fluctuation and Oxidative Stress Between Two Short-term Therapies for Type 2 Diabetes Unknown status NCT02526810 Phase 4 insulin lispro;Insulin Glargine
47 Investigation of a Switch From Insulin Therapy to a Metformin & Saxagliptin Combination in Patients With Type 2 Diabetes Mellitus Unknown status NCT01206647 Phase 4 Metformin and Saxagliptin
48 A Study on Ca Blocker Versus AII Antagonists in Hypertension With Type 2 Diabetes Unknown status NCT00144144 Phase 4 Angiotensin II receptor antagonists, Calcium channel blocker
49 A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients Unknown status NCT00336310 Phase 4 Repaglinide
50 Study on the Efficacy aNd Safety of Jinlida Granules in Patients With Inadequately cOntrolled tYpe-2 Diabetes and dysLIpidemia Under liFe Style Intervention (ENJOY LIFE Study) Unknown status NCT02035644 Phase 4 Jinlida granules;placebo granules

Search NIH Clinical Center for Diabetes Mellitus, Noninsulin-Dependent

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cochrane evidence based reviews: diabetes mellitus, type 2

Genetic Tests for Diabetes Mellitus, Noninsulin-Dependent

Genetic tests related to Diabetes Mellitus, Noninsulin-Dependent:

id Genetic test Affiliating Genes
1 Diabetes Mellitus Type 2 29
2 Insulin Resistance 29
3 Diabetes Mellitus, Noninsulin-Dependent 24 NEUROD1

Anatomical Context for Diabetes Mellitus, Noninsulin-Dependent

MalaCards organs/tissues related to Diabetes Mellitus, Noninsulin-Dependent:

39
Endothelial, Heart, Kidney, Liver, Testes, Bone, Ovary
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Diabetes Mellitus, Noninsulin-Dependent:
id Tissue Anatomical CompartmentCell Relevance
1 Pancreas Islets of Langerhans Mature Beta Cells Potential therapeutic candidate, affected by disease
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Diabetes Mellitus, Noninsulin-Dependent