MCID: DBT029
MIFTS: 36

Diabetes Mellitus, Noninsulin-Dependent, Late Onset malady

Genetic diseases (common) category

Summaries for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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48OMIM, 34MalaCards
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MalaCards: Diabetes Mellitus, Noninsulin-Dependent, Late Onset is related to familial hyperinsulinism and hyperinsulinemic hypoglycemia. An important gene associated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset is GCK (glucokinase (hexokinase 4)), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and HIF-1-alpha transcription factor network. The compounds chromium picolinate and preproinsulin have been mentioned in the context of this disorder. Related mouse phenotypes are cellular and immune system.

Description from OMIM:48 125853

Aliases & Classifications for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

diabetes mellitus, noninsulin-dependent, late onset 48


Related Diseases for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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18GeneCards, 19GeneDecks
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Diseases in the Diabetes Mellitus, Noninsulin-Dependent family:

Kcnj11-Related Susceptibility to Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Noninsulin-Dependent 1
diabetes mellitus, noninsulin-dependent, late onset Diabetes Mellitus, Noninsulin-Dependent, 2

Diseases related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1familial hyperinsulinism10.1GCK
2hyperinsulinemic hypoglycemia10.1GCK
3neonatal diabetes mellitus10.1GCK, HNF1B
4hyperuricemia10.1GCK, HNF1B
5type 1 diabetes mellitus10.0HNF4A, GCK
6maturity-onset diabetes of the young10.0HNF4A, HNF1B, GCK
7lipodystrophy10.0INSR, AKT2
8polycystic ovary syndrome10.0INSR, IRS1
9developmental disabilities10.0HNF4A, HNF1B
10insulinoma10.0GCK, HNF4A, INSR
11hyperinsulinism10.0INSR, IRS1, GCK
12cholestasis10.0HNF4A, HNF1B
13metabolic syndrome x10.0GCK, HNF4A, INSR
14glucose intolerance10.0INSR, GCK, SLC2A4
15leiomyoma10.0INSR, IRS1
16galactosemia10.0HNF4A, HNF1B, IRS1
17primary hyperoxaluria10.0HNF4A, INSR, HNF1B
18hypertriglyceridemia10.0INSR, IRS1, SLC2A4
19hepatoblastoma10.0HNF4A, INSR
20sepsis10.0INSR, IRS1, SLC2A4
21hypoglycemia10.0INSR, SLC2A4, HNF4A, GCK
22kidney cancer10.0HNF4A, SLC2A4, INSR, HNF1B
23pancreatic cancer10.0SLC2A4, AKT2, IRS1, HNF4A
24hepatocellular carcinoma10.0HNF4A, INSR, HNF1B, IRS1
25liver cirrhosis10.0SLC2A4, IRS1, HNF4A, INSR
26ischemia9.9MAPK8IP1, SLC2A4, GCK, INSR
27ovarian cancer9.9AKT2, HNF1B, HNF4A, SLC2A4, INSR
28adenocarcinoma9.9HNF4A, HNF1B, AKT2, INSR, SLC2A4
29gestational diabetes9.9GCK, IRS1, SLC2A4, HNF4A, INSR
30obesity9.9HNF4A, INSR, SLC2A4, GCK, IRS1
31tongue squamous cell carcinoma9.9HNF4A, INSR, IRS1, AKT2, SLC2A4
32colorectal cancer9.9PPP1R3A, IRS1, HNF4A, INSR
33breast cancer9.9SLC2A4, AKT2, INSR, HNF4A, IRS1
34diabetes mellitus, noninsulin-dependent9.9SLC2A4, HNF4A, HNF1B, MAPK8IP1, IRS1
35hyperglycemia9.9HNF1B, IRS1, SLC2A4, GCK, HNF4A, INSR
36prostate cancer9.9HNF1B, MAPK8IP1, AKT2, IRS1, INSR, HNF4A
37diabetes mellitus9.8INSR, SLC2A4, HNF4A, HNF1B, AKT2, IRS1
38type 2 diabetes mellitus9.8HNF1B, PPP1R3A, IRS1, HNF4A, INSR, SLC2A4
39insulin resistance9.8SLC2A4, IRS1, AKT2, GCK, HNF4A, INSR

Graphical network of the top 20 diseases related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset:



Diseases related to diabetes mellitus, noninsulin-dependent, late onset

Symptoms for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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48OMIM
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Clinical features from OMIM:

125853

Drugs & Therapeutics for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Search NIH Clinical Center for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Search CenterWatch for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Genetic Tests for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Anatomical Context for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Animal Models for Diabetes Mellitus, Noninsulin-Dependent, Late Onset or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1HNF4A, MAPK8IP1, AKT2, IRS1, INSR
2MP:00053878.0INSR, IRS1, AKT2, HNF1B, SLC2A4
3MP:00053757.7PPP1R3A, INSR, IRS1, AKT2, SLC2A4
4MP:00053697.5PPP1R3A, INSR, IRS1, AKT2, HNF1B, SLC2A4
5MP:00053797.4INSR, IRS1, AKT2, MAPK8IP1, HNF1B, GCK
6MP:00053707.1SLC2A4, INSR, IRS1, AKT2, MAPK8IP1, HNF1B
7MP:00107686.9INSR, IRS1, AKT2, MAPK8IP1, HNF1B, HNF4A
8MP:00053786.3PPP1R3A, INSR, IRS1, AKT2, MAPK8IP1, HNF1B
9MP:00053766.2PPP1R3A, INSR, IRS1, AKT2, MAPK8IP1, HNF1B

Publications for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

65 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

1 (show all 15)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
3AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
4INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
5INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenic, Pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
6GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
7SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
8GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
9IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
10IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
11MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
12NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
13ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
14ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
15HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Search GEO for disease gene expression data for Diabetes Mellitus, Noninsulin-Dependent, Late Onset.

Pathways for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Sources:
51PathCards, 39NCBI BioSystems Database, 55R&D Systems, 54QIAGEN, 31KEGG, 61Thomson Reuters, 62Tocris Bioscience, 56Reactome, 5Cell Signaling Technology, 52PharmGKB
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Pathways related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7HNF4A, GCK
29.7GCK, HNF4A
39.7AKT2, INSR
49.6SLC2A4, AKT2
59.5SLC2A4, HNF4A
69.5IRS1, INSR
79.5IRS1, INSR
89.5IRS1, INSR
9
Show member pathways
9.3GCK, HNF4A, INSR
10
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.3GCK, AKT2, IRS1
11
Show member pathways
MAPK signaling pathway39
9.2GCK, MAPK8IP1, AKT2
12
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.2INSR, IRS1, AKT2
13
Show member pathways
Insulin Pathway39
9.2AKT2, IRS1, INSR
149.2AKT2, IRS1, INSR
15
Show member pathways
9.2INSR, IRS1, AKT2
16
Show member pathways
9.2INSR, IRS1, AKT2
17
Show member pathways
9.1SLC2A4, AKT2, IRS1
189.1IRS1, AKT2, SLC2A4
199.1IRS1, AKT2, SLC2A4
20
Show member pathways
9.0AKT2, HNF1B, HNF4A, GCK
21
Show member pathways
8.9AKT2, INSR, PPP1R3A
228.7INSR, AKT2, HNF4A, SLC2A4
23
Show member pathways
8.7PPP1R3A, INSR, IRS1
24
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
8.6INSR, IRS1, AKT2, SLC2A4
25
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.6SLC2A4, AKT2, IRS1, INSR
26
Show member pathways
8.6SLC2A4, AKT2, IRS1, INSR
27
Show member pathways
8.6SLC2A4, AKT2, IRS1, INSR
28
Show member pathways
8.5SLC2A4, GCK, HNF4A, HNF1B, AKT2
298.3SLC2A4, AKT2, INSR, PPP1R3A
308.2INSR, IRS1, AKT2, HNF4A, SLC2A4
31
Show member pathways
8.2PPP1R3A, INSR, IRS1, SLC2A4
32
Show member pathways
8.1INSR, IRS1, AKT2, MAPK8IP1, HNF4A
33
Show member pathways
8.0INSR, IRS1, AKT2, MAPK8IP1, SLC2A4
34
Show member pathways
7.9SLC2A4, GCK, HNF4A, HNF1B, IRS1, INSR
357.8SLC2A4, AKT2, IRS1, INSR, PPP1R3A
36
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
7.5PPP1R3A, INSR, IRS1, AKT2, GCK, SLC2A4
37
Show member pathways
7.3PPP1R3A, INSR, IRS1, AKT2, MAPK8IP1, HNF4A

Compounds for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1chromium picolinate4610.1GCK, INSR
2preproinsulin469.9GCK, INSR
3vanadyl sulfate469.8IRS1, INSR
4grp-1469.8INSR, SLC2A4
53-o-methylglucose469.6SLC2A4, GCK, INSR
6ag 1024469.6INSR, IRS1
7aicar46 25 1211.6SLC2A4, INSR, GCK
8sulfonylurea469.5IRS1, GCK, SLC2A4
9moxonidine469.5INSR, IRS1
10biotin46 25 1211.5GCK, SLC2A4, INSR
112,4-dinitrophenol469.4IRS1, SLC2A4
12mannose 6-phosphate46 2510.4SLC2A4, GCK, INSR
13mannitol46 1210.4INSR, GCK, IRS1
14vanadium469.4SLC2A4, IRS1, INSR
15phenylarsine oxide469.4SLC2A4, INSR, IRS1
16pioglitazone30 46 52 1212.3SLC2A4, IRS1, INSR
17anisomycin46 1210.3SLC2A4, IRS1, INSR
18c-peptide469.2HNF4A, IRS1, INSR, GCK
19rosiglitazone30 46 52 25 1213.2IRS1, SLC2A4, INSR
20phosphatidylinositol-3,4,5-trisphosphate46 2510.2INSR, IRS1, SLC2A4
21phosphoenolpyruvate46 1210.1HNF4A, GCK, SLC2A4, IRS1
22troglitazone46 30 62 1212.1IRS1, INSR, SLC2A4
23glucose 6-phosphate46 2510.1PPP1R3A, SLC2A4, GCK
24sterol469.1SLC2A4, IRS1, HNF4A, GCK
25streptozotocin469.1SLC2A4, IRS1, INSR, GCK
26glucosamine46 25 1211.1SLC2A4, GCK, IRS1, INSR
27metformin46 52 1211.1GCK, SLC2A4, INSR, IRS1
28citrate469.1SLC2A4, INSR, GCK
29ibmx46 62 3011.0IRS1, SLC2A4, INSR
30sb 20358046 6210.0INSR, SLC2A4, AKT2, IRS1
31fatty acid469.0HNF4A, IRS1, SLC2A4, GCK
32rapamycin469.0IRS1, INSR, SLC2A4, AKT2
33palmitate469.0INSR, IRS1, HNF4A, SLC2A4
34wortmannin469.0AKT2, IRS1, INSR, SLC2A4
35pd 98,059468.9IRS1, HNF4A, INSR, SLC2A4
36arginine468.8GCK, HNF4A, INSR, IRS1, HNF1B
37phosphotyrosine468.7IRS1, MAPK8IP1, SLC2A4, INSR
38ly294002468.7IRS1, SLC2A4, GCK, INSR, AKT2
39glycerol46 25 1210.7INSR, IRS1, SLC2A4, GCK, HNF4A
40retinoic acid46 259.7IRS1, SLC2A4, HNF4A, HNF1B, GCK
41dexamethasone46 52 30 1211.6INSR, HNF4A, SLC2A4, GCK, IRS1
42alanine468.6INSR, GCK, HNF4A, IRS1, SLC2A4
43phosphatidylinositol468.6AKT2, SLC2A4, IRS1, HNF4A, INSR
44h2o2468.4SLC2A4, GCK, INSR, IRS1
452-deoxyglucose46 129.3INSR, PPP1R3A, IRS1, SLC2A4, GCK
46threonine467.7INSR, IRS1, AKT2, MAPK8IP1, HNF4A, GCK
47serine467.7IRS1, INSR, AKT2, MAPK8IP1, SLC2A4, GCK
48glycogen46 258.5AKT2, PPP1R3A, IRS1, INSR, HNF4A, GCK
49lipid467.5IRS1, INSR, AKT2, HNF4A, GCK, PPP1R3A
50glucose466.5PPP1R3A, GCK, HNF4A, HNF1B, MAPK8IP1, AKT2

GO Terms for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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17Gene Ontology
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Cellular components related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:0059019.5IRS1, INSR
2insulin receptor complexGO:0058999.2IRS1, INSR

Biological processes related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1glycogen biosynthetic processGO:0059789.9GCK, AKT2
2positive regulation of glycolytic processGO:0458219.9GCK, INSR
3positive regulation of glucose import in response to insulin stimulusGO:20012759.8AKT2, IRS1
4positive regulation of glucose metabolic processGO:0109079.8IRS1, AKT2
5positive regulation of fatty acid beta-oxidationGO:0320009.8AKT2, IRS1
6regulation of insulin secretionGO:0507969.7GCK, HNF4A
7hexose transportGO:0086459.7GCK, SLC2A4
8endocrine pancreas developmentGO:0310189.6HNF1B, HNF4A, GCK
9response to glucoseGO:0097499.6HNF1B, HNF4A
10positive regulation of glucose importGO:0463269.4AKT2, IRS1, INSR
11glucose transportGO:0157589.3SLC2A4, GCK
12insulin receptor signaling pathwayGO:0082869.3INSR, IRS1, AKT2
13carbohydrate metabolic processGO:0059759.2SLC2A4, GCK, INSR
14positive regulation of glycogen biosynthetic processGO:0457259.1INSR, IRS1, AKT2, GCK
15cellular response to insulin stimulusGO:0328698.6SLC2A4, GCK, AKT2, IRS1, INSR
16glucose homeostasisGO:0425938.5INSR, IRS1, HNF4A, GCK, SLC2A4

Molecular functions related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SH2 domain bindingGO:0421699.5IRS1, INSR
2insulin-like growth factor receptor bindingGO:0051599.4IRS1, INSR
3phosphatidylinositol 3-kinase bindingGO:0435489.2IRS1, INSR
4protein bindingGO:0055156.9SLC2A4, INSR, IRS1, AKT2, MAPK8IP1, HNF1B

Products for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Sources for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet