MCID: DBT029
MIFTS: 39

Diabetes Mellitus, Noninsulin-Dependent, Late Onset malady

Genetic diseases (common) category
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Summaries for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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MalaCards based summary: Diabetes Mellitus, Noninsulin-Dependent, Late Onset is related to type 2 diabetes mellitus and familial hyperinsulinism. An important gene associated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset is GCK (glucokinase (hexokinase 4)), and among its related pathways are Insulin secretion and Integration of energy metabolism. The compounds incretin and preproinsulin have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and cellular.

Description from OMIM:46 125853

Aliases & Classifications for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Diabetes Mellitus, Noninsulin-Dependent, Late Onset, Aliases & Descriptions:

Name: Diabetes Mellitus, Noninsulin-Dependent, Late Onset 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Diseases in the Diabetes Mellitus, Noninsulin-Dependent family:

Kcnj11-Related Susceptibility to Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Noninsulin-Dependent 1
diabetes mellitus, noninsulin-dependent, late onset Diabetes Mellitus, Noninsulin-Dependent, 2

Diseases related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1type 2 diabetes mellitus10.5GPD2
2familial hyperinsulinism10.4GCK, ABCC8
3hyperinsulinemic hypoglycemia10.4ABCC8, GCK
4permanent neonatal diabetes mellitus10.4ABCC8, GCK
5neonatal diabetes mellitus10.3ABCC8, HNF1B, GCK, SLC2A2
6diabetes mellitus, noninsulin-dependent10.3SLC30A8, HMGA1
7hyperammonemia multi-gene panels10.3GCK, ABCC8
8hyperinsulinism10.3ABCC8, INSR, IRS1, GCK
9polycystic ovary syndrome10.3INSR, IRS1, CAPN10
10maturity-onset diabetes of the young10.2PAX4, NEUROD1, HNF1B, HNF4A, GCK
11hypertriglyceridemia10.2SLC2A4, IRS1, INSR
12cystic kidney10.2ENPP1, HNF1B
13liver cirrhosis10.2INSR, IRS1, HNF4A, SLC2A4
14ovarian cancer10.1INSR, AKT2, HNF1B, HNF4A, SLC2A4
15kidney cancer10.1INSR, HNF1B, HNF4A, SLC2A4
16ischemia10.1ABCC8, INSR, MAPK8IP1, GCK, SLC2A4
17hypercholesterolemia10.1HMGA1, CAPN10, INSR
18sepsis10.1INSR, IRS1, IL6, SLC2A4
19type 1 diabetes mellitus10.1INSR, PAX4, NEUROD1, HNF4A, GCK, ENPP1
20pancreatic cancer10.1IRS1, AKT2, HNF4A, HMGA1, SLC2A4
21metabolic syndrome x10.0ABCC8, INSR, CAPN10, HNF4A, GCK, SLC2A2
22hypoglycemia10.0ABCC8, INSR, HNF4A, GCGR, GCK, SLC2A4
23insulinoma10.0ABCC8, GPD2, INSR, PAX4, HNF4A, GCK
24tongue squamous cell carcinoma10.0INSR, IRS1, AKT2, HNF4A, SLC2A4
25glucose intolerance10.0INSR, PAX4, CAPN10, GCK, ENPP1, SLC2A4
26coronary artery anomaly9.9IRS1, IL6, HMGA1
27adenocarcinoma9.9INSR, NEUROD1, AKT2, HNF1B, HNF4A, HMGA1
28atherosclerosis9.9IRS1, IL6, CAPN10, HNF4A, ENPP1
29primary hyperoxaluria9.9INSR, IL6, CAPN10, HNF1B, HNF4A, ENPP1
30liver cancer9.9INSR, IRS1, IL6, HNF1B, HNF4A, HMGA1
31prostate cancer9.8INSR, IRS1, AKT2, IL6, MAPK8IP1, HNF1B
32gestational diabetes9.8GCK, HNF4A, CAPN10, IRS1, INSR, ABCC8
33breast cancer9.8INSR, IRS1, AKT2, HNF4A, HMGA1, ENPP1
34hyperglycemia9.5SLC2A4, ENPP1, GCK, GCGR, HNF4A, HNF1B
35obesity9.5GCGR, HNF4A, CAPN10, IL6, IRS1, INSR
36insulin resistance9.0SLC2A4, ENPP1, GCK, GCGR, HMGA1, HNF4A
37diabetes mellitus9.0SLC30A8, ABCC8, INSR, SLC2A2, SLC2A4, ENPP1

Graphical network of the top 20 diseases related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset:



Diseases related to diabetes mellitus, noninsulin-dependent, late onset

Symptoms for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Clinical features from OMIM:

125853

Drugs & Therapeutics for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Search NIH Clinical Center for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Genetic Tests for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Anatomical Context for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Animal Models for Diabetes Mellitus, Noninsulin-Dependent, Late Onset or affiliated genes

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MGI Mouse Phenotypes related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7INSR, NEUROD1, IL6, CAPN10, HNF1B, GCK
2MP:00053848.6INSR, NEUROD1, IRS1, AKT2, IL6, MAPK8IP1
3MP:00036318.5NEUROD1, AKT2, IL6, MAPK8IP1, HNF4A, ENPP1
4MP:00053698.3PPP1R3A, INSR, IRS1, AKT2, IL6, HNF1B
5MP:00053858.0INSR, IRS1, IL6, CAPN10, HMGA1, ENPP1
6MP:00053758.0PPP1R3A, GPD2, INSR, IRS1, AKT2, IL6
7MP:00053877.9INSR, IRS1, AKT2, IL6, CAPN10, HNF1B
8MP:00053707.3GPD2, INSR, IRS1, AKT2, IL6, MAPK8IP1
9MP:00107687.3AKT2, IRS1, NEUROD1, PAX4, INSR, GPD2
10MP:00053796.6NEUROD1, IRS1, AKT2, IL6, MAPK8IP1, CAPN10
11MP:00053786.1NEUROD1, IRS1, AKT2, IL6, MAPK8IP1, CAPN10
12MP:00053766.0PPP1R3A, ABCC8, GPD2, INSR, NEUROD1, IRS1

Publications for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

64 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

6 (show all 32)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
3ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
4PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
5AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
6SLC30A8NM_173851.2(SLC30A8): c.412C> T (p.Arg138Ter)single nucleotide variantprotectivers200185429GRCh37Chr 8, 118165323: 118165323
7SLC30A8NM_173851.2(SLC30A8): c.101_107delAAGATCA (p.Lys34Serfs)deletionprotectiveGRCh37Chr 8, 118159222: 118159228
8LIPCLIPC, -250G-Asingle nucleotide variantrisk factor
9INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
10INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
11IL6IL6, -174G-Csingle nucleotide variantrisk factor
12GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
13SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
14GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
15IGF2BP2NM_006548.4(IGF2BP2): c.239+29254C> Asingle nucleotide variantrisk factorrs4402960GRCh37Chr 3, 185511687: 185511687
16IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
17IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
18HMGA1HMGA1, 1-BP INS, IVS5, -13insertionrisk factor
19RETNRETN, +62G-Asingle nucleotide variantrisk factor
20CAPN10NM_023083.3(CAPN10): c.471-176G> Asingle nucleotide variantrisk factorrs3792267GRCh37Chr 2, 241531174: 241531174
21CAPN10CAPN10, IVS6, INS/DEL, 39-BPindelrisk factor
22CAPN10CAPN10, IVS13, g.16378G-Tsingle nucleotide variantrisk factor
23CAPN10CAPN10, IVS3, g.4841T-Csingle nucleotide variantrisk factor
24MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
25TCF7L2NM_030756.4(TCF7L2): c.382-41435C> Tsingle nucleotide variantrisk factorrs7903146GRCh37Chr 10, 114758349: 114758349
26TCF7L2NM_030756.4(TCF7L2): c.483+9017G> Tsingle nucleotide variantrisk factorrs12255372GRCh37Chr 10, 114808902: 114808902
27TCF7L2NM_030756.4(TCF7L2): c.483+7162G> Csingle nucleotide variantrisk factorrs11196205GRCh37Chr 10, 114807047: 114807047
28NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
29KCNJ11NM_000525.3(KCNJ11): c.67A> G (p.Lys23Glu)single nucleotide variantdrug response, risk factorrs5219GRCh37Chr 11, 17409572: 17409572
30ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
31ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
32HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Search GEO for disease gene expression data for Diabetes Mellitus, Noninsulin-Dependent, Late Onset.

Pathways for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Pathways related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9ABCC8, GCK, SLC2A2
2
Show member pathways
9.9ABCC8, GCGR, SLC2A2
3
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
9.9GCK, SLC2A4, SLC2A2
49.9HNF4A, SLC2A4, SLC2A2
5
Show member pathways
9.8INSR, IRS1, AKT2
6
Show member pathways
Insulin Pathway37
9.8AKT2, IRS1, INSR
7
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.8INSR, IRS1, AKT2
89.8SLC2A4, AKT2, IRS1
9
Show member pathways
9.8PPP1R3A, INSR, AKT2
10
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.8IRS1, AKT2, GCK, SLC2A2
119.7SLC2A2, GCK, HNF4A, ABCC8
129.7GCK, IL6, NEUROD1
13
Show member pathways
9.7CAPN10, AKT2, INSR
14
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.7IL6, AKT2, IRS1
159.6IL6, AKT2, INSR
169.6INSR, AKT2, HNF4A, SLC2A4
17
Show member pathways
9.6SLC2A4, AKT2, IRS1, INSR
18
Show member pathways
9.5INSR, NEUROD1, HNF4A, GCK, SLC2A2
199.5ABCC8, IRS1, AKT2, SLC2A4
20
Show member pathways
9.5HMGA1, GCK, SLC2A4, SLC2A2
219.5SLC2A4, AKT2, INSR, PPP1R3A
22
Show member pathways
9.5SLC2A4, IRS1, INSR, PPP1R3A
23
Show member pathways
9.4IL6, AKT2, IRS1, INSR
249.4IL6, AKT2, IRS1, INSR
25
Show member pathways
9.4PPP1R3A, INSR, IRS1, IL6
26
Show member pathways
9.3ABCC8, GCK, SLC2A4, SLC2A2, SLC30A8
27
Show member pathways
9.3AKT2, IL6, HNF4A, SLC2A4, SLC2A2
289.2IRS1, IL6, HMGA1, SLC2A4
29
Show member pathways
9.2PPP1R3A, INSR, AKT2, IL6, GCGR
30
Show member pathways
9.2PAX4, NEUROD1, AKT2, HNF1B, HNF4A, GCK
31
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.2INSR, IRS1, AKT2, IL6, SLC2A4
32
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.2INSR, IRS1, AKT2, IL6, SLC2A4
33
Show member pathways
9.2INSR, IRS1, AKT2, IL6, SLC2A4
34
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.1PPP1R3A, INSR, IRS1, AKT2, GCK, SLC2A4
35
Show member pathways
9.1INSR, IRS1, AKT2, IL6, MAPK8IP1, HNF4A
369.0PPP1R3A, INSR, IRS1, AKT2, ENPP1, SLC2A4
37
Show member pathways
9.0INSR, IRS1, AKT2, IL6, MAPK8IP1, SLC2A4
38
Show member pathways
8.9PAX4, NEUROD1, AKT2, HNF1B, HNF4A, GCK
39
Show member pathways
8.9ABCC8, GPD2, GCGR, GCK, ENPP1, SLC2A4
408.9INSR, NEUROD1, IRS1, AKT2, HNF4A, ENPP1
41
Show member pathways
8.6SLC2A2, ABCC8, INSR, SLC2A4, GCK, HNF4A
42
Show member pathways
8.4PPP1R3A, INSR, IRS1, AKT2, IL6, MAPK8IP1

Compounds for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Compounds related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1incretin4410.3GCGR, SLC2A2, GCK
2preproinsulin4410.3GCK, INSR, SLC2A2
3vanadium4410.1IRS1, SLC2A4, INSR
4fructose44 1111.1GCK, GCGR, SLC2A2, SLC2A4
53-o-methylglucose4410.1GCK, SLC2A2, SLC2A4, INSR
6gliclazide44 50 1112.0SLC2A4, INSR, ABCC8
7glimepiride44 50 1112.0ABCC8, INSR, SLC2A4
8glucosamine44 24 1112.0IRS1, INSR, GCK, SLC2A4
9c-peptide4410.0HNF4A, IRS1, INSR, GCK, SLC2A2
10mannitol44 1110.9GCK, IRS1, INSR, SLC2A2
11glucose 6-phosphate44 2410.9PPP1R3A, GCK, SLC2A4, SLC2A2
12phosphoenolpyruvate44 1110.9HNF4A, GCK, SLC2A2, IRS1, SLC2A4
13repaglinide50 44 1111.9NEUROD1, PAX4, SLC30A8, ABCC8
14streptozotocin449.9GCK, SLC2A4, INSR, IRS1, SLC2A2
15sulfonylurea449.9ABCC8, IRS1, GCK, SLC2A4, SLC2A2
16palmitate449.8HNF4A, INSR, IRS1, SLC2A4
17pyruvate449.8GPD2, GCK, HNF4A, SLC2A4, SLC2A2
18aicar44 24 1111.8INSR, SLC2A4, GCK
19katp449.8ABCC8, SLC2A2, GCK
20glycerol44 24 1111.8INSR, IRS1, HNF4A, GCK, SLC2A4
21pioglitazone28 44 50 1112.7INSR, SLC2A4, IL6, IRS1
22anisomycin44 1110.7INSR, IL6, IRS1, SLC2A4
23ibmx44 61 2811.7SLC2A2, INSR, IRS1, SLC2A4
242-deoxyglucose44 1110.6PPP1R3A, IRS1, SLC2A2, SLC2A4, GCK, INSR
25sterol449.6SLC2A2, HMGA1, IRS1, HNF4A, GCK, SLC2A4
26oligonucleotide449.6HNF4A, SLC2A2, GCK, GCGR, HNF1B, AKT2
27rosiglitazone28 44 50 24 1113.5INSR, IRS1, IL6, SLC2A4
28troglitazone44 28 61 1112.5IL6, INSR, IRS1, SLC2A4
29metformin44 50 1111.5ENPP1, GCK, IRS1, INSR, ABCC8, SLC2A4
30h2o2449.5GCK, IRS1, SLC2A4, SLC2A2, INSR, GPD2
31sb 20358044 6110.5IL6, INSR, IRS1, AKT2, SLC2A4
32pd 98,059449.4IL6, SLC2A4, INSR, IRS1, HNF4A
33atp44 2810.3MAPK8IP1, ABCC8, HNF4A, SLC2A2, GCGR, GCK
34potassium44 24 1111.3IRS1, ABCC8, GCK, SLC2A2, CAPN10
35rapamycin449.3SLC2A4, ENPP1, HMGA1, AKT2, IRS1, INSR
36testosterone44 61 24 1112.2INSR, IRS1, IL6, SLC2A4, ABCC8, HNF4A
37ly294002449.1GCK, SLC2A4, HMGA1, IL6, IRS1, INSR
38dexamethasone44 50 28 1112.1GCK, ENPP1, INSR, SLC2A4, HNF4A, IRS1
39fatty acid449.0HMGA1, GCGR, ABCC8, ENPP1, GCK, SLC2A4
40cholesterol44 28 24 1112.0ABCC8, IL6, CAPN10, HNF1B, HNF4A, HMGA1
41retinoic acid44 249.9NEUROD1, IRS1, GCK, HNF1B, SLC2A4, HMGA1
42arginine448.8CAPN10, SLC2A2, GCK, HMGA1, HNF4A, IRS1
43threonine448.8SLC2A4, ENPP1, GCK, HMGA1, HNF4A, MAPK8IP1
44phosphatidylinositol448.8AKT2, INSR, ENPP1, IRS1, HNF4A, SLC2A4
45serine448.5HNF4A, SLC2A4, ENPP1, GCK, HMGA1, AKT2
46tyrosine448.4SLC2A4, ENPP1, HMGA1, AKT2, HNF4A, IRS1
47calcium44 50 24 1111.4HNF4A, ENPP1, HMGA1, GCK, CAPN10, GCGR
48glycogen44 249.1SLC2A2, SLC2A4, GCK, GCGR, HNF4A, CAPN10
49lipid447.7IRS1, ENPP1, GCK, HMGA1, HNF4A, CAPN10
50glucose446.3HNF4A, GPD2, INSR, PAX4, NEUROD1, IRS1

GO Terms for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Cellular components related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor complexGO:0058999.7IRS1, INSR
2plasma membraneGO:0058868.0INSR, IRS1, AKT2, CAPN10, GCGR, ENPP1

Biological processes related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of cell cycle arrestGO:07115610.4AKT2, NEUROD1
2positive regulation of glucose import in response to insulin stimulusGO:200127510.4AKT2, IRS1
3positive regulation of glucose metabolic processGO:01090710.3AKT2, IRS1
4positive regulation of fatty acid beta-oxidationGO:03200010.3AKT2, IRS1
5positive regulation of glycolytic processGO:04582110.3INSR, GCK
6hexose transportGO:00864510.2SLC2A2, SLC2A4, GCK
7glucose transportGO:01575810.1GCK, SLC2A4, SLC2A2
8insulin secretionGO:03007310.1SLC30A8, HNF1B, NEUROD1
9negative regulation of gluconeogenesisGO:04572110.1GCK, IL6
10signal transduction involved in regulation of gene expressionGO:02301910.1HNF4A, NEUROD1
11positive regulation of glycogen biosynthetic processGO:04572510.1INSR, IRS1, AKT2, GCK
12positive regulation of cell differentiationGO:04559710.0NEUROD1, PAX4
13energy reserve metabolic processGO:00611210.0SLC2A2, GCGR, ABCC8
14positive regulation of type B pancreatic cell apoptotic processGO:200067610.0CAPN10, IL6
15positive regulation of insulin secretionGO:03202410.0CAPN10, GCK, SLC30A8
16response to glucoseGO:00974910.0NEUROD1, HNF1B, HNF4A, SLC30A8
17insulin receptor signaling pathwayGO:0082869.9AKT2, IRS1, INSR
18regulation of insulin secretionGO:0507969.9ABCC8, NEUROD1, HNF4A, GCK, SLC2A2
19bone remodelingGO:0468499.9IL6, ENPP1
20negative regulation of insulin receptor signaling pathwayGO:0466279.9IRS1, ENPP1
21positive regulation of glucose importGO:0463269.8CAPN10, AKT2, IRS1, INSR
22glycogen biosynthetic processGO:0059789.8GCK, AKT2
23carbohydrate metabolic processGO:0059759.7ABCC8, INSR, GCK, SLC2A4, SLC2A2
24transmembrane transportGO:0550859.6ABCC8, GCK, SLC2A4, SLC2A2, SLC30A8
25positive regulation of transcription, DNA-templatedGO:0458939.5NEUROD1, IL6, HNF1B, HNF4A, HMGA1
26endocrine pancreas developmentGO:0310189.3PAX4, NEUROD1, IL6, HNF1B, HNF4A, GCK
27small molecule metabolic processGO:0442819.2ABCC8, GPD2, GCGR, GCK, ENPP1, SLC2A4
28glucose homeostasisGO:0425939.1SLC30A8, INSR, SLC2A4, GCK, GCGR, HNF4A
29cellular response to insulin stimulusGO:0328699.1INSR, IRS1, AKT2, CAPN10, GCK, ENPP1

Molecular functions related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1D-glucose transmembrane transporter activityGO:05505610.2SLC2A2, SLC2A4
2insulin-like growth factor receptor bindingGO:00515910.1INSR, IRS1
3phosphatidylinositol 3-kinase bindingGO:04354810.0IRS1, INSR
4insulin receptor bindingGO:00515810.0ENPP1, IRS1
5sequence-specific DNA bindingGO:0435659.4HNF4A, HNF1B, NEUROD1, PAX4
6sequence-specific DNA binding transcription factor activityGO:0037009.2PAX4, NEUROD1, HNF1B, HNF4A, HMGA1
7protein bindingGO:0055157.7INSR, NEUROD1, IRS1, AKT2, IL6, MAPK8IP1

Products for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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  • Antibodies
  • Proteins
  • Lysates

Sources for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet