MCID: DBT029
MIFTS: 37

Diabetes Mellitus, Noninsulin-Dependent, Late Onset malady

Genetic diseases (common) category

Summaries for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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MalaCards based summary: Diabetes Mellitus, Noninsulin-Dependent, Late Onset is related to familial hyperinsulinism and permanent neonatal diabetes mellitus. An important gene associated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset is GCK (glucokinase (hexokinase 4)), and among its related pathways are Insulin secretion and Integration of energy metabolism. The compounds incretin and alloxan have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and muscle.

Description from OMIM:46 125853

Aliases & Classifications for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Diabetes Mellitus, Noninsulin-Dependent, Late Onset, Aliases & Descriptions:

Name: Diabetes Mellitus, Noninsulin-Dependent, Late Onset 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Diseases in the Diabetes Mellitus, Noninsulin-Dependent family:

Kcnj11-Related Susceptibility to Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Noninsulin-Dependent 1
diabetes mellitus, noninsulin-dependent, late onset Diabetes Mellitus, Noninsulin-Dependent, 2

Diseases related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1familial hyperinsulinism10.5GCK, ABCC8
2permanent neonatal diabetes mellitus10.4ABCC8, GCK
3hyperinsulinemic hypoglycemia10.4ABCC8, GCK
4neonatal diabetes mellitus10.3HNF1B, ABCC8, GCK, SLC2A2
5cystic kidney10.3ENPP1, HNF1B
6hyperammonemia multi-gene panels10.3GCK, ABCC8
7type 1 diabetes mellitus10.3GCK, HNF4A
8maturity-onset diabetes of the young10.2PAX4, HNF4A, GCK, NEUROD1, HNF1B
9polycystic ovary syndrome10.2CAPN10, IRS1
10hyperuricemia10.2GCK, HNF1B
11ovarian cancer10.2AKT2, HNF4A, SLC2A4, HNF1B
12hyperinsulinism10.2GCK, IRS1, ABCC8, RETN
13diabetes mellitus, noninsulin-dependent10.2SLC30A8, RETN, HMGA1
14ischemia10.1GCK, SLC2A4, MAPK8IP1, ABCC8
15galactosemia10.1RETN, HNF1B, HNF4A, IRS1
16liver cirrhosis10.1SLC2A4, IRS1, HNF4A, RETN
17hypoglycemia10.1GCGR, ABCC8, SLC2A2, HNF4A, SLC2A4, GCK
18insulinoma10.1HNF4A, GCK, GPD2, PAX4, SLC2A2, ABCC8
19pancreatic cancer10.1HNF4A, IRS1, AKT2, HMGA1, SLC2A4
20primary hyperoxaluria10.1HNF1B, ENPP1, RETN
21hypercholesterolemia10.1HMGA1, CAPN10, RETN
22type 2 diabetes mellitus10.0MAPK8IP1, AKT2, PPP1R3A, IRS1, HNF1B, HNF4A
23sepsis10.0IL6, SLC2A4, RETN, IRS1
24adenocarcinoma10.0HNF4A, NEUROD1, AKT2, HNF1B, HMGA1, SLC2A4
25chronic kidney failure10.0RETN, ENPP1, HNF1B, IL6
26coronary artery anomaly10.0IRS1, RETN, IL6, ENPP1
27liver cancer10.0HMGA1, HNF1B, HNF4A, SLC2A2, IRS1, IL6
28metabolic syndrome x10.0GCK, HNF4A, CAPN10, RETN, ABCC8, SLC2A2
29prostate cancer9.9IRS1, IL6, MAPK8IP1, AKT2, HNF1B, HNF4A
30glucose intolerance9.9SLC2A4, GCK, RETN, CAPN10, ENPP1, PAX4
31breast cancer9.8IRS1, AKT2, HMGA1, ENPP1, SLC2A4, SLC2A2
32atherosclerosis9.8CAPN10, ENPP1, IRS1, IL6, RETN, HNF4A
33gestational diabetes9.7SLC2A4, ENPP1, GCK, HNF4A, CAPN10, RETN
34hyperglycemia9.5SLC2A2, SLC2A4, ENPP1, GCK, ABCC8, PAX4
35obesity9.4IL6, SLC2A2, ABCC8, IRS1, RETN, CAPN10
36insulin resistance8.9ENPP1, GCK, GCGR, HMGA1, HNF4A, HNF1B
37diabetes mellitus8.9SLC2A4, SLC2A2, SLC30A8, NEUROD1, IRS1, AKT2

Graphical network of the top 20 diseases related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset:



Diseases related to diabetes mellitus, noninsulin-dependent, late onset

Symptoms for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Clinical features from OMIM:

125853

Drugs & Therapeutics for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Drug clinical trials:

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Search NIH Clinical Center for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Genetic Tests for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Anatomical Context for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Animal Models for Diabetes Mellitus, Noninsulin-Dependent, Late Onset or affiliated genes

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MGI Mouse Phenotypes related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5NEUROD1, IL6, CAPN10, HNF1B, GCK, ENPP1
2MP:00053698.4PPP1R3A, IRS1, AKT2, IL6, HNF1B, ENPP1
3MP:00053878.2AKT2, IL6, CAPN10, HNF1B, HMGA1, ENPP1
4MP:00053757.6PPP1R3A, GPD2, IRS1, AKT2, RETN, IL6
5MP:00107687.4IL6, AKT2, IRS1, NEUROD1, PAX4, GPD2
6MP:00053707.0GPD2, IRS1, AKT2, RETN, IL6, MAPK8IP1
7MP:00053796.8IRS1, AKT2, IL6, MAPK8IP1, CAPN10, HNF1B
8MP:00053786.2PPP1R3A, GPD2, PAX4, NEUROD1, IRS1, AKT2
9MP:00053765.7IRS1, AKT2, RETN, IL6, MAPK8IP1, CAPN10

Publications for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

63 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

7 (show all 32)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2ENPP1ENPP1, IVS20AS, 1-BP DEL, T, -11deletionrisk factor
3ENPP1NM_006208.2(ENPP1): c.517A> C (p.Lys173Gln)single nucleotide variantrisk factorrs1044498GRCh37Chr 6, 132172368: 132172368
4PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
5AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
6SLC30A8NM_173851.2(SLC30A8): c.412C> T (p.Arg138Ter)single nucleotide variantprotectivers200185429GRCh37Chr 8, 118165323: 118165323
7SLC30A8NM_173851.2(SLC30A8): c.101_107delAAGATCA (p.Lys34Serfs)deletionprotectiveGRCh37Chr 8, 118159222: 118159228
8LIPCLIPC, -250G-Asingle nucleotide variantrisk factor
9INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
10INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenic, Pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
11IL6IL6, -174G-Csingle nucleotide variantrisk factor
12GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
13SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
14GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
15IGF2BP2NM_006548.4(IGF2BP2): c.239+29254C> Asingle nucleotide variantrisk factorrs4402960GRCh37Chr 3, 185511687: 185511687
16IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
17IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
18HMGA1HMGA1, 1-BP INS, IVS5, -13insertionrisk factor
19RETNRETN, +62G-Asingle nucleotide variantrisk factor
20CAPN10NM_023083.3(CAPN10): c.471-176G> Asingle nucleotide variantrisk factorrs3792267GRCh37Chr 2, 241531174: 241531174
21CAPN10CAPN10, IVS6, INS/DEL, 39-BPindelrisk factor
22CAPN10CAPN10, IVS13, g.16378G-Tsingle nucleotide variantrisk factor
23CAPN10CAPN10, IVS3, g.4841T-Csingle nucleotide variantrisk factor
24MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
25TCF7L2NM_030756.4(TCF7L2): c.382-41435C> Tsingle nucleotide variantrisk factorrs7903146GRCh37Chr 10, 114758349: 114758349
26TCF7L2NM_030756.4(TCF7L2): c.483+9017G> Tsingle nucleotide variantrisk factorrs12255372GRCh37Chr 10, 114808902: 114808902
27TCF7L2NM_030756.4(TCF7L2): c.483+7162G> Csingle nucleotide variantrisk factorrs11196205GRCh37Chr 10, 114807047: 114807047
28NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
29KCNJ11NM_000525.3(KCNJ11): c.67A> G (p.Lys23Glu)single nucleotide variantdrug response, risk factorrs5219GRCh37Chr 11, 17409572: 17409572
30ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
31ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
32HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Search GEO for disease gene expression data for Diabetes Mellitus, Noninsulin-Dependent, Late Onset.

Pathways for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Pathways related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9ABCC8, GCK, SLC2A2
2
Show member pathways
9.9ABCC8, GCGR, SLC2A2
3
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
9.9GCK, SLC2A4, SLC2A2
49.9SLC2A2, SLC2A4, HNF4A
59.8SLC2A4, HNF4A, AKT2
69.8IRS1, AKT2, SLC2A4
7
Show member pathways
9.8SLC2A4, AKT2, IRS1
8
Show member pathways
9.8NEUROD1, HNF4A, GCK, SLC2A2
9
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling59
Leptin signaling pathway37
9.8IRS1, AKT2, GCK, SLC2A2
109.7ABCC8, HNF4A, GCK, SLC2A2
119.7SLC2A4, AKT2, PPP1R3A
129.7GCK, IL6, NEUROD1
13
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
9.7IL6, AKT2, IRS1
149.5ABCC8, IRS1, AKT2, SLC2A4
15
Show member pathways
9.5SLC2A2, SLC2A4, GCK, HMGA1
16
Show member pathways
9.4IRS1, AKT2, IL6, SLC2A4
17
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.4IRS1, AKT2, IL6, SLC2A4
18
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
9.4PPP1R3A, IRS1, AKT2, GCK, SLC2A4
19
Show member pathways
9.3ABCC8, GCK, SLC2A4, SLC2A2, SLC30A8
20
Show member pathways
9.3IRS1, AKT2, IL6, MAPK8IP1, HNF4A
21
Show member pathways
9.3AKT2, IL6, HNF4A, SLC2A4, SLC2A2
229.2SLC2A4, ENPP1, AKT2, IRS1, PPP1R3A
23
Show member pathways
9.2IRS1, AKT2, IL6, MAPK8IP1, SLC2A4
24
Show member pathways
9.2PAX4, NEUROD1, AKT2, HNF1B, HNF4A, GCK
259.1NEUROD1, IRS1, AKT2, HNF4A, ENPP1, SLC2A4
26
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway59
8.9SLC2A4, IL6, RETN, AKT2, IRS1
27
Show member pathways
8.9PAX4, NEUROD1, AKT2, HNF1B, HNF4A, GCK
28
Show member pathways
8.9SLC2A2, SLC2A4, ENPP1, GCK, GCGR, GPD2
29
Show member pathways
8.9SLC2A2, ABCC8, SLC2A4, GCK, HNF4A, HNF1B
308.8IRS1, RETN, IL6, HMGA1, SLC2A4
31
Show member pathways
8.7PPP1R3A, IRS1, AKT2, IL6, MAPK8IP1, CAPN10

Compounds for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Compounds related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1incretin4410.4GCK, SLC2A2, GCGR
2alloxan4410.4SLC2A2, GCK
33-o-methylglucose4410.3SLC2A4, GCK, SLC2A2
4[3h]2-deoxyglucose2910.3SLC2A4, SLC2A2
5katp4410.2SLC2A2, ABCC8, GCK
6preproinsulin4410.2GCK, SLC2A2
7fructose44 1211.1SLC2A2, GCGR, GCK, SLC2A4
8streptozotocin4410.1IRS1, SLC2A2, SLC2A4, GCK
9glucose 6-phosphate44 2511.0GCK, SLC2A2, PPP1R3A, SLC2A4
10glucosamine44 25 1211.9IRS1, GCK, SLC2A4
11glycerol 3-phosphate44 2510.9GCK, SLC2A4, GPD2
12phosphoenolpyruvate44 1210.9HNF4A, GCK, SLC2A4, SLC2A2, IRS1
13repaglinide50 44 1211.9SLC30A8, NEUROD1, PAX4, ABCC8
14glycerol44 25 1211.9SLC2A4, GCK, IRS1, HNF4A
15sulfonylurea449.9SLC2A2, ABCC8, IRS1, GCK, SLC2A4
16pyruvate449.8SLC2A2, SLC2A4, GCK, GPD2, HNF4A
17glimepiride44 50 1211.8RETN, ABCC8, SLC2A4
182-deoxyglucose44 1210.8IRS1, SLC2A4, SLC2A2, GCK, PPP1R3A
19thiazolidinedione449.8SLC2A4, RETN, IRS1
20oligonucleotide449.8AKT2, SLC2A2, HNF1B, HNF4A, GCGR, GCK
21c-peptide449.8GCK, IRS1, RETN, HNF4A, SLC2A2
22leucine449.7GCK, MAPK8IP1, HNF4A, ABCC8, SLC2A2
23potassium44 25 1211.6CAPN10, IRS1, ABCC8, SLC2A2, GCK
24pioglitazone29 44 50 1212.5SLC2A4, RETN, IRS1, IL6
25rapamycin449.5SLC2A4, ENPP1, HMGA1, AKT2, IRS1
26rosiglitazone29 44 50 25 1213.5IRS1, IL6, SLC2A4, RETN
27h2o2449.4SLC2A4, GPD2, IRS1, GCK, SLC2A2
28atp44 2910.4HNF4A, GCGR, ABCC8, ENPP1, SLC2A2, GCK
29sb 20358044 6010.3AKT2, SLC2A4, IL6, IRS1
30anisomycin44 1210.3IRS1, SLC2A4, IL6
31metformin44 50 1211.2ENPP1, SLC2A4, RETN, ABCC8, IRS1, GCK
32sterol449.1RETN, HNF4A, GCK, SLC2A2, HMGA1, SLC2A4
33phosphatidylinositol449.1AKT2, ENPP1, IRS1, SLC2A4, RETN, HNF4A
34nitric oxide44 25 1211.1GCK, RETN, MAPK8IP1, SLC2A4, IL6, HNF4A
35alanine449.1GCK, SLC2A4, HNF4A, RETN, IL6, IRS1
36arginine449.0SLC2A2, ABCC8, HMGA1, IRS1, CAPN10, HNF1B
37testosterone44 60 25 1212.0RETN, IL6, ABCC8, IRS1, HNF4A, SLC2A4
38threonine449.0SLC2A4, IRS1, ENPP1, MAPK8IP1, HNF4A, AKT2
39retinoic acid44 259.9NEUROD1, HNF4A, IL6, HNF1B, HMGA1, GCK
40ly294002448.9IRS1, AKT2, RETN, GCK, SLC2A4, IL6
41dexamethasone44 50 29 1211.9ENPP1, IL6, SLC2A4, HNF4A, RETN, IRS1
42estrogen448.8IL6, HNF4A, RETN, HMGA1, IRS1, AKT2
43serine448.8HNF4A, ENPP1, GCK, MAPK8IP1, AKT2, HMGA1
44fatty acid448.6HMGA1, RETN, GCGR, GCK, ENPP1, IRS1
45cholesterol44 29 25 1211.5ABCC8, GCK, HMGA1, HNF4A, HNF1B, CAPN10
46tyrosine448.2IRS1, ABCC8, IL6, AKT2, RETN, ENPP1
47calcium44 50 25 1211.0ENPP1, MAPK8IP1, GCK, ABCC8, GPD2, NEUROD1
48glycogen44 258.9SLC2A2, SLC2A4, ENPP1, GCK, GCGR, ABCC8
49lipid447.5AKT2, SLC2A4, ENPP1, GCK, HMGA1, HNF4A
50glucose446.1CAPN10, RETN, AKT2, IRS1, NEUROD1, PAX4

GO Terms for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Cellular components related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.2SLC30A8, SLC2A2, SLC2A4, ENPP1, GCGR, CAPN10

Biological processes related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1regulation of cell cycle arrestGO:07115610.4AKT2, NEUROD1
2positive regulation of glucose import in response to insulin stimulusGO:200127510.3AKT2, IRS1
3positive regulation of glucose metabolic processGO:01090710.3AKT2, IRS1
4positive regulation of fatty acid beta-oxidationGO:03200010.3AKT2, IRS1
5positive regulation of glycogen biosynthetic processGO:04572510.3IRS1, AKT2, GCK
6hexose transportGO:00864510.2SLC2A2, SLC2A4, GCK
7glucose transportGO:01575810.1GCK, SLC2A4, SLC2A2
8insulin secretionGO:03007310.1SLC30A8, HNF1B, NEUROD1
9signal transduction involved in regulation of gene expressionGO:02301910.1HNF4A, NEUROD1
10negative regulation of gluconeogenesisGO:04572110.1IL6, GCK
11positive regulation of glucose importGO:04632610.1CAPN10, AKT2, IRS1
12positive regulation of cell differentiationGO:04559710.0NEUROD1, PAX4
13energy reserve metabolic processGO:00611210.0SLC2A2, GCGR, ABCC8
14positive regulation of type B pancreatic cell apoptotic processGO:200067610.0IL6, CAPN10
15positive regulation of insulin secretionGO:03202410.0CAPN10, GCK, SLC30A8
16response to glucoseGO:00974910.0SLC30A8, HNF4A, HNF1B, NEUROD1
17regulation of insulin secretionGO:0507969.9ABCC8, NEUROD1, HNF4A, GCK, SLC2A2
18negative regulation of insulin receptor signaling pathwayGO:0466279.9IRS1, ENPP1
19glycogen biosynthetic processGO:0059789.8GCK, AKT2
20bone remodelingGO:0468499.8ENPP1, IL6
21carbohydrate metabolic processGO:0059759.7ABCC8, GCK, SLC2A4, SLC2A2
22response to insulinGO:0328689.7IRS1, RETN, IL6
23transmembrane transportGO:0550859.5ABCC8, GCK, SLC2A4, SLC2A2, SLC30A8
24positive regulation of transcription, DNA-templatedGO:0458939.5NEUROD1, IL6, HNF1B, HNF4A, HMGA1
25glucose homeostasisGO:0425939.4NEUROD1, IRS1, HNF4A, GCGR, GCK, SLC2A4
26endocrine pancreas developmentGO:0310189.3SLC2A2, PAX4, NEUROD1, IL6, HNF1B, HNF4A
27cellular response to insulin stimulusGO:0328699.3IRS1, AKT2, CAPN10, GCK, ENPP1, SLC2A4
28small molecule metabolic processGO:0442819.2ABCC8, GPD2, GCGR, GCK, ENPP1, SLC2A4

Molecular functions related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1D-glucose transmembrane transporter activityGO:05505610.1SLC2A2, SLC2A4
2insulin receptor bindingGO:00515810.0ENPP1, IRS1
3sequence-specific DNA bindingGO:0435659.4HNF4A, HNF1B, NEUROD1, PAX4
4sequence-specific DNA binding transcription factor activityGO:0037009.2PAX4, NEUROD1, HNF1B, HNF4A, HMGA1
5protein bindingGO:0055157.8NEUROD1, IRS1, AKT2, IL6, MAPK8IP1, HNF1B

Products for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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4CDC
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