MCID: DBT029
MIFTS: 36

Diabetes Mellitus, Noninsulin-Dependent, Late Onset malady

Genetic diseases (common) category
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Summaries for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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47OMIM, 33MalaCards
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MalaCards: Diabetes Mellitus, Noninsulin-Dependent, Late Onset is related to familial hyperinsulinism and hyperinsulinemic hypoglycemia. An important gene associated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset is GCK (glucokinase (hexokinase 4)), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and HIF-1-alpha transcription factor network. The compounds chromium picolinate and preproinsulin have been mentioned in the context of this disorder. Related mouse phenotypes are cellular and immune system.

Description from OMIM:47 125853

Aliases & Classifications for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

diabetes mellitus, noninsulin-dependent, late onset 47


Related Diseases for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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17GeneCards, 18GeneDecks
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Diseases in the Diabetes Mellitus, Noninsulin-Dependent family:

Kcnj11-Related Susceptibility to Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Noninsulin-Dependent 1
diabetes mellitus, noninsulin-dependent, late onset Diabetes Mellitus, Noninsulin-Dependent, 2

Diseases related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1familial hyperinsulinism10.1GCK
2hyperinsulinemic hypoglycemia10.1GCK
3neonatal diabetes mellitus10.1GCK, HNF1B
4hyperuricemia10.1GCK, HNF1B
5type 1 diabetes mellitus10.0HNF4A, GCK
6maturity-onset diabetes of the young10.0HNF4A, HNF1B, GCK
7lipodystrophy10.0INSR, AKT2
8polycystic ovary syndrome10.0INSR, IRS1
9developmental disabilities10.0HNF4A, HNF1B
10insulinoma10.0GCK, HNF4A, INSR
11hyperinsulinism10.0INSR, IRS1, GCK
12cholestasis10.0HNF4A, HNF1B
13metabolic syndrome x10.0GCK, HNF4A, INSR
14glucose intolerance10.0INSR, GCK, SLC2A4
15leiomyoma10.0INSR, IRS1
16galactosemia10.0HNF4A, HNF1B, IRS1
17primary hyperoxaluria10.0HNF4A, INSR, HNF1B
18hypertriglyceridemia10.0INSR, IRS1, SLC2A4
19hepatoblastoma10.0HNF4A, INSR
20sepsis10.0INSR, IRS1, SLC2A4
21hypoglycemia10.0INSR, SLC2A4, HNF4A, GCK
22kidney cancer10.0HNF4A, SLC2A4, INSR, HNF1B
23pancreatic cancer10.0SLC2A4, AKT2, IRS1, HNF4A
24hepatocellular carcinoma10.0HNF4A, INSR, HNF1B, IRS1
25liver cirrhosis10.0SLC2A4, IRS1, HNF4A, INSR
26ischemia9.9MAPK8IP1, SLC2A4, GCK, INSR
27ovarian cancer9.9AKT2, HNF1B, HNF4A, SLC2A4, INSR
28adenocarcinoma9.9HNF4A, HNF1B, AKT2, INSR, SLC2A4
29gestational diabetes9.9GCK, IRS1, SLC2A4, HNF4A, INSR
30obesity9.9HNF4A, INSR, SLC2A4, GCK, IRS1
31tongue squamous cell carcinoma9.9HNF4A, INSR, IRS1, AKT2, SLC2A4
32colorectal cancer9.9PPP1R3A, IRS1, HNF4A, INSR
33breast cancer9.9SLC2A4, AKT2, INSR, HNF4A, IRS1
34diabetes mellitus, noninsulin-dependent9.9SLC2A4, HNF4A, HNF1B, MAPK8IP1, IRS1
35hyperglycemia9.9HNF1B, IRS1, SLC2A4, GCK, HNF4A, INSR
36prostate cancer9.9HNF1B, MAPK8IP1, AKT2, IRS1, INSR, HNF4A
37diabetes mellitus9.8INSR, SLC2A4, HNF4A, HNF1B, AKT2, IRS1
38type 2 diabetes mellitus9.8HNF1B, PPP1R3A, IRS1, HNF4A, INSR, SLC2A4
39insulin resistance9.8SLC2A4, IRS1, AKT2, GCK, HNF4A, INSR

Graphical network of the top 20 diseases related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset:



Diseases related to diabetes mellitus, noninsulin-dependent, late onset

Symptoms for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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47OMIM
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Clinical features from OMIM:

125853

Drugs & Therapeutics for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Search NIH Clinical Center for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Genetic Tests for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Anatomical Context for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Animal Models for Diabetes Mellitus, Noninsulin-Dependent, Late Onset or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1HNF4A, MAPK8IP1, AKT2, IRS1, INSR
2MP:00053878.0INSR, IRS1, AKT2, HNF1B, SLC2A4
3MP:00053757.7PPP1R3A, INSR, IRS1, AKT2, SLC2A4
4MP:00053697.5PPP1R3A, INSR, IRS1, AKT2, HNF1B, SLC2A4
5MP:00053797.4INSR, IRS1, AKT2, MAPK8IP1, HNF1B, GCK
6MP:00053707.1SLC2A4, INSR, IRS1, AKT2, MAPK8IP1, HNF1B
7MP:00107686.9INSR, IRS1, AKT2, MAPK8IP1, HNF1B, HNF4A
8MP:00053786.3PPP1R3A, INSR, IRS1, AKT2, MAPK8IP1, HNF1B
9MP:00053766.2PPP1R3A, INSR, IRS1, AKT2, MAPK8IP1, HNF1B

Publications for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

64 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Diabetes Mellitus, Noninsulin-Dependent, Late Onset:

1 (show all 15)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
3AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
4INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
5INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenic, Pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
6GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
7SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
8GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
9IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
10IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
11MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
12NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
13ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
14ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
15HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Search GEO for disease gene expression data for Diabetes Mellitus, Noninsulin-Dependent, Late Onset.

Pathways for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Sources:
50PathCards, 38NCBI BioSystems Database, 54R&D Systems, 53QIAGEN, 30KEGG, 60Thomson Reuters, 61Tocris Bioscience, 55Reactome, 5Cell Signaling Technology, 51PharmGKB
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Pathways related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7HNF4A, GCK
29.7GCK, HNF4A
39.7AKT2, INSR
49.6SLC2A4, AKT2
59.5SLC2A4, HNF4A
69.5IRS1, INSR
79.5IRS1, INSR
89.5IRS1, INSR
9
Show member pathways
9.3GCK, HNF4A, INSR
10
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.3GCK, AKT2, IRS1
11
Show member pathways
MAPK signaling pathway38
9.2GCK, MAPK8IP1, AKT2
12
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.2INSR, IRS1, AKT2
13
Show member pathways
Insulin Pathway38
9.2AKT2, IRS1, INSR
149.2AKT2, IRS1, INSR
15
Show member pathways
9.2INSR, IRS1, AKT2
16
Show member pathways
9.2INSR, IRS1, AKT2
17
Show member pathways
9.1SLC2A4, AKT2, IRS1
189.1IRS1, AKT2, SLC2A4
199.1IRS1, AKT2, SLC2A4
20
Show member pathways
9.0AKT2, HNF1B, HNF4A, GCK
21
Show member pathways
8.9AKT2, INSR, PPP1R3A
228.7INSR, AKT2, HNF4A, SLC2A4
23
Show member pathways
8.7PPP1R3A, INSR, IRS1
24
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
8.6INSR, IRS1, AKT2, SLC2A4
25
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.6SLC2A4, AKT2, IRS1, INSR
26
Show member pathways
8.6SLC2A4, AKT2, IRS1, INSR
27
Show member pathways
8.6SLC2A4, AKT2, IRS1, INSR
28
Show member pathways
8.5SLC2A4, GCK, HNF4A, HNF1B, AKT2
298.3SLC2A4, AKT2, INSR, PPP1R3A
308.2INSR, IRS1, AKT2, HNF4A, SLC2A4
31
Show member pathways
8.2PPP1R3A, INSR, IRS1, SLC2A4
32
Show member pathways
8.1INSR, IRS1, AKT2, MAPK8IP1, HNF4A
33
Show member pathways
8.0INSR, IRS1, AKT2, MAPK8IP1, SLC2A4
34
Show member pathways
7.9SLC2A4, GCK, HNF4A, HNF1B, IRS1, INSR
357.8SLC2A4, AKT2, IRS1, INSR, PPP1R3A
36
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
7.5PPP1R3A, INSR, IRS1, AKT2, GCK, SLC2A4
37
Show member pathways
7.3PPP1R3A, INSR, IRS1, AKT2, MAPK8IP1, HNF4A

Compounds for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1chromium picolinate4510.1GCK, INSR
2preproinsulin459.9GCK, INSR
3vanadyl sulfate459.8IRS1, INSR
4grp-1459.8INSR, SLC2A4
53-o-methylglucose459.6SLC2A4, GCK, INSR
6ag 1024459.6INSR, IRS1
7aicar45 24 1111.6SLC2A4, INSR, GCK
8sulfonylurea459.5IRS1, GCK, SLC2A4
9moxonidine459.5INSR, IRS1
10biotin45 24 1111.5GCK, SLC2A4, INSR
112,4-dinitrophenol459.4IRS1, SLC2A4
12mannose 6-phosphate45 2410.4SLC2A4, GCK, INSR
13mannitol45 1110.4INSR, GCK, IRS1
14vanadium459.4SLC2A4, IRS1, INSR
15phenylarsine oxide459.4SLC2A4, INSR, IRS1
16pioglitazone29 45 51 1112.3SLC2A4, IRS1, INSR
17anisomycin45 1110.3SLC2A4, IRS1, INSR
18c-peptide459.2HNF4A, IRS1, INSR, GCK
19rosiglitazone29 45 51 24 1113.2IRS1, SLC2A4, INSR
20phosphatidylinositol-3,4,5-trisphosphate45 2410.2INSR, IRS1, SLC2A4
21phosphoenolpyruvate45 1110.1HNF4A, GCK, SLC2A4, IRS1
22troglitazone45 29 61 1112.1IRS1, INSR, SLC2A4
23glucose 6-phosphate45 2410.1PPP1R3A, SLC2A4, GCK
24sterol459.1SLC2A4, IRS1, HNF4A, GCK
25streptozotocin459.1SLC2A4, IRS1, INSR, GCK
26glucosamine45 24 1111.1SLC2A4, GCK, IRS1, INSR
27metformin45 51 1111.1GCK, SLC2A4, INSR, IRS1
28citrate459.1SLC2A4, INSR, GCK
29ibmx45 61 2911.0IRS1, SLC2A4, INSR
30sb 20358045 6110.0INSR, SLC2A4, AKT2, IRS1
31fatty acid459.0HNF4A, IRS1, SLC2A4, GCK
32rapamycin459.0IRS1, INSR, SLC2A4, AKT2
33palmitate459.0INSR, IRS1, HNF4A, SLC2A4
34wortmannin459.0AKT2, IRS1, INSR, SLC2A4
35pd 98,059458.9IRS1, HNF4A, INSR, SLC2A4
36arginine458.8GCK, HNF4A, INSR, IRS1, HNF1B
37phosphotyrosine458.7IRS1, MAPK8IP1, SLC2A4, INSR
38ly294002458.7IRS1, SLC2A4, GCK, INSR, AKT2
39glycerol45 24 1110.7INSR, IRS1, SLC2A4, GCK, HNF4A
40retinoic acid45 249.7IRS1, SLC2A4, HNF4A, HNF1B, GCK
41dexamethasone45 51 29 1111.6INSR, HNF4A, SLC2A4, GCK, IRS1
42alanine458.6INSR, GCK, HNF4A, IRS1, SLC2A4
43phosphatidylinositol458.6AKT2, SLC2A4, IRS1, HNF4A, INSR
44h2o2458.4SLC2A4, GCK, INSR, IRS1
452-deoxyglucose45 119.3INSR, PPP1R3A, IRS1, SLC2A4, GCK
46threonine457.7INSR, IRS1, AKT2, MAPK8IP1, HNF4A, GCK
47serine457.7IRS1, INSR, AKT2, MAPK8IP1, SLC2A4, GCK
48glycogen45 248.5AKT2, PPP1R3A, IRS1, INSR, HNF4A, GCK
49lipid457.5IRS1, INSR, AKT2, HNF4A, GCK, PPP1R3A
50glucose456.5PPP1R3A, GCK, HNF4A, HNF1B, MAPK8IP1, AKT2

GO Terms for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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16Gene Ontology
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Cellular components related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:0059019.5IRS1, INSR
2insulin receptor complexGO:0058999.2IRS1, INSR

Biological processes related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1glycogen biosynthetic processGO:0059789.9GCK, AKT2
2positive regulation of glycolytic processGO:0458219.9GCK, INSR
3positive regulation of glucose import in response to insulin stimulusGO:20012759.8AKT2, IRS1
4positive regulation of glucose metabolic processGO:0109079.8IRS1, AKT2
5positive regulation of fatty acid beta-oxidationGO:0320009.8AKT2, IRS1
6regulation of insulin secretionGO:0507969.7GCK, HNF4A
7hexose transportGO:0086459.7GCK, SLC2A4
8endocrine pancreas developmentGO:0310189.6HNF1B, HNF4A, GCK
9response to glucoseGO:0097499.6HNF1B, HNF4A
10positive regulation of glucose importGO:0463269.4AKT2, IRS1, INSR
11glucose transportGO:0157589.3SLC2A4, GCK
12insulin receptor signaling pathwayGO:0082869.3INSR, IRS1, AKT2
13carbohydrate metabolic processGO:0059759.2SLC2A4, GCK, INSR
14positive regulation of glycogen biosynthetic processGO:0457259.1INSR, IRS1, AKT2, GCK
15cellular response to insulin stimulusGO:0328698.6SLC2A4, GCK, AKT2, IRS1, INSR
16glucose homeostasisGO:0425938.5INSR, IRS1, HNF4A, GCK, SLC2A4

Molecular functions related to Diabetes Mellitus, Noninsulin-Dependent, Late Onset according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SH2 domain bindingGO:0421699.5IRS1, INSR
2insulin-like growth factor receptor bindingGO:0051599.4IRS1, INSR
3phosphatidylinositol 3-kinase bindingGO:0435489.2IRS1, INSR
4protein bindingGO:0055156.9SLC2A4, INSR, IRS1, AKT2, MAPK8IP1, HNF1B

Products for genes affiliated with Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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Sources for Diabetes Mellitus, Noninsulin-Dependent, Late Onset

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet