MCID: DBT064
MIFTS: 47

Diabetes Mellitus, Transient Neonatal, 1

Categories: Genetic diseases, Rare diseases, Fetal diseases, Endocrine diseases, Metabolic diseases

Aliases & Classifications for Diabetes Mellitus, Transient Neonatal, 1

MalaCards integrated aliases for Diabetes Mellitus, Transient Neonatal, 1:

Name: Diabetes Mellitus, Transient Neonatal, 1 53 13 69
Transient Neonatal Diabetes Mellitus 12 49 55 36 28 14 69
Tndm1 53 49 71
Tndm 53 49 55
Transient Neonatal Diabetes Mellitus 1 71 28
Diabetes Mellitus, Transient Neonatal 53 49
Dmtn 53 49
Chromosome 6-Associated Transient Diabetes Mellitus 49
Diabetes Mellitus, 6q24-Related Transient Neonatal 49
Neonatal Diabetes Mellitus, Transient 72

Characteristics:

Orphanet epidemiological data:

55
transient neonatal diabetes mellitus
Inheritance: Autosomal dominant,Autosomal recessive,Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Antenatal,Neonatal;

OMIM:

53
Inheritance:
imprinted, paternally expressed gene on chromosome 6q22-q23


Classifications:

Orphanet: 55  
Rare endocrine diseases


Summaries for Diabetes Mellitus, Transient Neonatal, 1

OMIM : 53 Neonatal diabetes mellitus (NDM), defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity, with an estimated incidence of 1 in 400,000 neonates (Shield, 2000). In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes (606176). In a significant number of patients with transient neonatal diabetes mellitus, type II diabetes appears later in life (Arthur et al., 1997). The major cause of transient neonatal diabetes (TND) is aberrant expression of imprinted genes at chromosome 6q24, associated in 20% of cases with DNA hypomethylation at the TND differentially methylated region (DMR), which lies within the imprinted promoter of the PLAGL1 gene (603044; Mackay et al., 2005). Over 50% of individuals with TND and hypomethylation at 6q24 also show mosaic DNA hypomethylation at other imprinted loci throughout the genome and a range of additional clinical features. (601410)

MalaCards based summary : Diabetes Mellitus, Transient Neonatal, 1, also known as transient neonatal diabetes mellitus, is related to paternal uniparental disomy of chromosome 6 and diabetes mellitus, and has symptoms including intellectual disability, muscular hypotonia and failure to thrive. An important gene associated with Diabetes Mellitus, Transient Neonatal, 1 is ZFP57 (ZFP57 Zinc Finger Protein), and among its related pathways/superpathways are Type II diabetes mellitus and FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include heart and pancreatic islet, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A neonatal diabetes mellitus characterized by hyperglycemia during the neonatal period that remits during infancy but recurs in later life in most patients.

NIH Rare Diseases : 49 Transient neonatal diabetes mellitus (TNDB) is a type of diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood. Affected individuals have slow growth before birth followed by hyperglycemia, dehydration and failure to thrive in infancy. Approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24. These cases are referred to as 6q24-related TNDB; most (but not all) of these cases are not inherited. Other genetic causes include mutations in the KCNJ11 and ABCC8 genes, which usually cause permanent neonatal diabetes. Treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin. Last updated: 8/28/2012

UniProtKB/Swiss-Prot : 71 Transient neonatal diabetes mellitus 1: Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes.

Wikipedia : 72 Transient neonatal diabetes mellitus (TNDM) is a form of diabetes mellitus presenting at birth that is... more...

Related Diseases for Diabetes Mellitus, Transient Neonatal, 1

Diseases in the Neonatal Diabetes Mellitus family:

Diabetes Mellitus, Transient Neonatal, 1 Diabetes Mellitus, Transient Neonatal, 2
Diabetes Mellitus, Transient Neonatal, 3 Diabetes Mellitus, 6q24-Related Transient Neonatal

Diseases related to Diabetes Mellitus, Transient Neonatal, 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 paternal uniparental disomy of chromosome 6 32.2 HYMAI PLAGL1
2 diabetes mellitus 32.2 ABCC8 INS KCNJ11 PLAGL1 ZFP57
3 neonatal diabetes mellitus 31.7 ABCC8 HYMAI INS KCNJ11 PLAGL1 ZFP57
4 maturity-onset diabetes of the young 29.8 ABCC8 INS KCNJ11
5 beckwith-wiedemann syndrome 29.3 ABCC8 INS KCNQ1OT1 NLRP2 PLAGL1 ZFP57
6 diabetes mellitus, transient neonatal, 2 12.4
7 diabetes mellitus, transient neonatal, 3 12.4
8 prostate cancer 11.3
9 malaria 11.1
10 hypotrichosis 11.1
11 hereditary spherocytosis 11.1
12 diabetes mellitus, 6q24-related transient neonatal 11.0
13 macroglossia 10.9
14 munchausen by proxy 10.5 ABCC8 KCNJ11
15 cardiomyopathy, dilated, 1o 10.4 ABCC8 KCNJ11
16 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 10.4 ABCC8 KCNJ11
17 usher syndrome, type ic 10.3 ABCC8 KCNJ11
18 fanconi-bickel syndrome 10.3 ABCC8 INS
19 factitious disorder 10.3 ABCC8 INS KCNJ11
20 hyperinsulinemic hypoglycemia, familial, 2 10.3 ABCC8 INS KCNJ11
21 acute insulin response 10.3 ABCC8 INS KCNJ11
22 monogenic diabetes 10.3 ABCC8 INS KCNJ11
23 pancreatic agenesis 10.3 ABCC8 INS KCNJ11
24 endocrine pancreas disease 10.3 ABCC8 INS KCNJ11
25 pancreas disease 10.2 ABCC8 INS KCNJ11
26 hyperinsulinemic hypoglycemia 10.2 ABCC8 INS KCNJ11
27 diabetes mellitus, permanent neonatal 10.2 ABCC8 INS KCNJ11
28 glucose metabolism disease 10.2 ABCC8 INS KCNJ11
29 taylor's syndrome 10.2 DNMT3L KCNJ11
30 hyperinsulinism 10.2 ABCC8 INS KCNJ11
31 hypoglycemia 10.2 ABCC8 INS KCNJ11
32 partial hydatidiform mole 10.2 KHDC3L NLRP7
33 hyperglycemia 10.2 ABCC8 INS KCNJ11
34 cantu syndrome 10.1 ABCC8 KCNJ11
35 arts syndrome 10.1 KCNQ1OT1 MEST
36 neuroblastoma 10.1
37 triploidy 10.1 KHDC3L NLRP7
38 spastic paraplegia 17, autosomal dominant 10.0 GNAS-AS1 GRB10 KCNQ1OT1
39 hydatidiform mole, recurrent, 1 10.0 KHDC3L NLRP7
40 carbohydrate metabolic disorder 10.0 ABCC8 INS
41 trophoblastic neoplasm 9.9 KHDC3L NLRP2 NLRP7
42 silver-russell syndrome 9.8 GRB10 KCNQ1OT1 MEST ZFP57
43 gestational trophoblastic neoplasm 9.7 HYMAI KHDC3L NLRP2 NLRP7

Graphical network of the top 20 diseases related to Diabetes Mellitus, Transient Neonatal, 1:



Diseases related to Diabetes Mellitus, Transient Neonatal, 1

Symptoms & Phenotypes for Diabetes Mellitus, Transient Neonatal, 1

Symptoms via clinical synopsis from OMIM:

53
Metabolic:
dehydration
insulin therapy usually required

Lab:
hyperglycemia

Misc:
usual resolution within 6 months
late predisposition to type 2 (insulin resistant) diabetes

Growth:
intrauterine growth retardation
severe failure to thrive

Endocrine:
transient neonatal diabetes mellitus (tndm)


Clinical features from OMIM:

601410

Human phenotypes related to Diabetes Mellitus, Transient Neonatal, 1:

55 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intellectual disability 55 31 frequent (33%) Frequent (79-30%) HP:0001249
2 muscular hypotonia 55 31 occasional (7.5%) Occasional (29-5%) HP:0001252
3 failure to thrive 55 31 hallmark (90%) Very frequent (99-80%) HP:0001508
4 hearing impairment 55 31 occasional (7.5%) Occasional (29-5%) HP:0000365
5 global developmental delay 55 31 frequent (33%) Frequent (79-30%) HP:0001263
6 renal tubular dysfunction 55 31 occasional (7.5%) Occasional (29-5%) HP:0000124
7 dehydration 55 31 hallmark (90%) Very frequent (99-80%) HP:0001944
8 weight loss 55 31 hallmark (90%) Very frequent (99-80%) HP:0001824
9 generalized myoclonic seizures 55 31 occasional (7.5%) Occasional (29-5%) HP:0002123
10 intrauterine growth retardation 55 31 hallmark (90%) Very frequent (99-80%) HP:0001511
11 generalized tonic-clonic seizures 55 31 occasional (7.5%) Occasional (29-5%) HP:0002069
12 arthrogryposis multiplex congenita 55 31 frequent (33%) Frequent (79-30%) HP:0002804
13 apraxia 55 31 occasional (7.5%) Occasional (29-5%) HP:0002186
14 downturned corners of mouth 55 31 frequent (33%) Frequent (79-30%) HP:0002714
15 coma 55 31 occasional (7.5%) Occasional (29-5%) HP:0001259
16 motor delay 55 31 frequent (33%) Frequent (79-30%) HP:0001270
17 prominent metopic ridge 55 31 frequent (33%) Frequent (79-30%) HP:0005487
18 hypovolemia 55 31 hallmark (90%) Very frequent (99-80%) HP:0011106
19 glycosuria 55 31 hallmark (90%) Very frequent (99-80%) HP:0003076
20 steatorrhea 55 31 occasional (7.5%) Occasional (29-5%) HP:0002570
21 abnormal heart morphology 55 31 occasional (7.5%) Occasional (29-5%) HP:0001627
22 bilateral ptosis 55 31 frequent (33%) Frequent (79-30%) HP:0001488
23 ketonuria 55 31 frequent (33%) Frequent (79-30%) HP:0002919
24 hyperglycemia 55 31 hallmark (90%) Very frequent (99-80%) HP:0003074
25 transient neonatal diabetes mellitus 55 31 hallmark (90%) Very frequent (99-80%) HP:0008255
26 abnormality of the pancreatic islet cells 55 31 hallmark (90%) Very frequent (99-80%) HP:0006476
27 contractures of the joints of the lower limbs 55 31 frequent (33%) Frequent (79-30%) HP:0005750
28 seizures 55 Occasional (29-5%)
29 neurodevelopmental delay 55 Frequent (79-30%)
30 abnormality of the upper urinary tract 55 Occasional (29-5%)
31 severe failure to thrive 31 HP:0001525
32 autoimmune antibody positivity 55 Excluded (0%)

GenomeRNAi Phenotypes related to Diabetes Mellitus, Transient Neonatal, 1 according to GeneCards Suite gene sharing:

25 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.66 UROD
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.66 KCNJ11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.66 KCNJ11
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.66 UROD KCNJ11 MEST
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.66 MEST
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.66 KCNJ11
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.66 MEST
8 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.66 MEST
9 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.66 UROD
10 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.66 KCNJ11
11 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.66 MEST
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.66 MEST
13 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.66 MEST
14 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.66 UROD
15 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.66 UROD
16 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.66 KCNJ11
17 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.66 KCNJ11
18 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.66 UROD
19 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.66 UROD
20 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.66 MEST

Drugs & Therapeutics for Diabetes Mellitus, Transient Neonatal, 1

Search Clinical Trials , NIH Clinical Center for Diabetes Mellitus, Transient Neonatal, 1

Genetic Tests for Diabetes Mellitus, Transient Neonatal, 1

Genetic tests related to Diabetes Mellitus, Transient Neonatal, 1:

# Genetic test Affiliating Genes
1 Transient Neonatal Diabetes Mellitus 1 28 HYMAI PLAGL1 ZFP57
2 Transient Neonatal Diabetes Mellitus 28

Anatomical Context for Diabetes Mellitus, Transient Neonatal, 1

MalaCards organs/tissues related to Diabetes Mellitus, Transient Neonatal, 1:

38
Heart, Pancreatic Islet

Publications for Diabetes Mellitus, Transient Neonatal, 1

Articles related to Diabetes Mellitus, Transient Neonatal, 1:

(show top 50) (show all 63)
# Title Authors Year
1
Personalized precision medicine in extreme preterm infants with transient neonatal diabetes mellitus. ( 28350539 )
2017
2
Transient neonatal diabetes mellitus and activating mutation in the KCNJ11 gene in two siblings. ( 28347637 )
2017
3
Maternal fertility problems and risk for transient neonatal diabetes mellitus. ( 28707511 )
2017
4
Transient Neonatal Diabetes Mellitus: A Challenge and Opportunity for Specialized Nursing Care. ( 28764822 )
2017
5
Sulfonylurea treatment in an infant with transient neonatal diabetes mellitus caused by an adenosine triphosphate binding cassette subfamily C member 8 gene mutation. ( 28804207 )
2017
6
Gene Variants Associated with Transient Neonatal Diabetes Mellitus in the Very Low Birth Weight Infant. ( 26315042 )
2015
7
Role of ZAC1 in transient neonatal diabetes mellitus and glucose metabolism. ( 26322169 )
2015
8
Neonatal Hyperglycemia due to Transient Neonatal Diabetes Mellitus in Puerto Rico. ( 26576310 )
2015
9
Transient Neonatal Diabetes Mellitus followed by recurrent asymptomatic hypoglycaemia: a case report. ( 26631065 )
2015
10
Treatment of transient neonatal diabetes mellitus: insulin pump or insulin glargine? Our experience. ( 25437016 )
2014
11
Chromosome 6q24 transient neonatal diabetes mellitus and protein sensitive hyperinsulinaemic hypoglycaemia. ( 24859512 )
2014
12
6q24 transient neonatal diabetes mellitus: the first case report from China. ( 25316252 )
2014
13
Relapsing 6q24-related transient neonatal diabetes mellitus successfully treated with a dipeptidyl peptidase-4 inhibitor: a case report. ( 24552466 )
2014
14
Clinical utility gene card for: Transient Neonatal Diabetes Mellitus, 6q24-related. ( 24569603 )
2014
15
Transient neonatal diabetes mellitus in a Turkish patient with three novel homozygous variants in the ZFP57 gene. ( 23748067 )
2013
16
Clinical presentation of 6q24 transient neonatal diabetes mellitus (6q24 TNDM) and genotype-phenotype correlation in an international cohort of patients. ( 23385738 )
2013
17
Insulin pump therapy in transient neonatal diabetes mellitus. ( 24904869 )
2013
18
Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1. ( 22547676 )
2012
19
Clinical and molecular basis of transient neonatal diabetes mellitus in Brazilian children. ( 22749773 )
2012
20
Transient neonatal diabetes mellitus caused by a de novoABCC8 gene mutation. ( 21738553 )
2011
21
Treatment of transient neonatal diabetes mellitus with subcutaneous insulin glargine in an extremely low birth weight neonate. ( 22768014 )
2011
22
Transient neonatal diabetes mellitus type 1. ( 20803656 )
2010
23
A case of transient neonatal diabetes mellitus. ( 21131807 )
2010
24
Partial paternal uniparental disomy of chromosome 6 in monozygotic twins with transient neonatal diabetes mellitus and macroglossia. ( 20412110 )
2010
25
Transient neonatal diabetes mellitus in an extremely preterm infant. ( 21686427 )
2009
26
An oral sulfonylurea in the treatment of transient neonatal diabetes mellitus. ( 19446154 )
2009
27
Placental mesenchymal dysplasia associated with transient neonatal diabetes mellitus and paternal UPD6. ( 18486206 )
2008
28
Transient neonatal diabetes mellitus in extremely preterm infant. ( 18192332 )
2008
29
Microarray-based DNA methylation analysis of imprinted loci in a patient with transient neonatal diabetes mellitus. ( 19012334 )
2008
30
Double paternal nondisjunction in an infant with transient neonatal diabetes mellitus and Klinefelter syndrome. ( 17366578 )
2007
31
A maternal hypomethylation syndrome presenting as transient neonatal diabetes mellitus. ( 16816970 )
2006
32
Epimutation of the TNDM locus and the Beckwith-Wiedemann syndrome centromeric locus in individuals with transient neonatal diabetes mellitus. ( 16402210 )
2006
33
Transient neonatal diabetes mellitus in an infant with paternal uniparental disomy of chromosome 6 including heterodisomy for 6q24. ( 17220064 )
2006
34
Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach. ( 16873690 )
2006
35
Monozygous triplets discordant for transient neonatal diabetes mellitus and for imprinting of the TNDM differentially methylated region. ( 15924231 )
2005
36
Bisulphite sequencing of the transient neonatal diabetes mellitus DMR facilitates a novel diagnostic test but reveals no methylation anomalies in patients of unknown aetiology. ( 15635480 )
2005
37
Transient neonatal diabetes mellitus is associated with a recurrent (R201H) KCNJ11 (KIR6.2) mutation. ( 16205880 )
2005
38
Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. ( 15286800 )
2004
39
Transient neonatal diabetes mellitus: a patient report. ( 14513885 )
2003
40
Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus. ( 11935319 )
2002
41
Transient neonatal diabetes mellitus, type 4, type 1 diabetes mellitus, or MODY: which disease is it, anyway? ( 12014522 )
2002
42
A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus. ( 11448939 )
2001
43
Transient neonatal diabetes mellitus in a child with paternal uniparental disomy of chromosome 6. ( 11515730 )
2001
44
Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus. ( 11297535 )
2001
45
An imprinted locus associated with transient neonatal diabetes mellitus. ( 10699182 )
2000
46
Variable features of transient neonatal diabetes mellitus with paternal isodisomy of chromosome 6. ( 10757646 )
2000
47
Localisation of a gene for transient neonatal diabetes mellitus to an 18.72 cR3000 (approximately 5.4 Mb) interval on chromosome 6q. ( 10204843 )
1999
48
Paternal uniparental disomy of chromosome 6 and transient neonatal diabetes mellitus. ( 9894800 )
1998
49
Transient neonatal diabetes mellitus or an exaggerated steroid response? A case study. ( 9592462 )
1998
50
Paternal uniparental isodisomy of chromosome 6 in transient neonatal diabetes mellitus. ( 9296544 )
1997

Variations for Diabetes Mellitus, Transient Neonatal, 1

UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Transient Neonatal, 1:

71
# Symbol AA change Variation ID SNP ID
1 ZFP57 p.Arg166His VAR_054771 rs199589695
2 ZFP57 p.His193Asn VAR_054772 rs78378398
3 ZFP57 p.His374Asp VAR_054773 rs79020217

ClinVar genetic disease variations for Diabetes Mellitus, Transient Neonatal, 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ZFP57 NM_001109809.2(ZFP57): c.783C> A (p.Cys261Ter) single nucleotide variant Pathogenic rs61730328 GRCh37 Chromosome 6, 29641105: 29641105
2 ZFP57 NM_001109809.2(ZFP57): c.317_318delAG (p.Glu106Valfs) deletion Pathogenic rs606231121 GRCh38 Chromosome 6, 29675420: 29675421
3 ZFP57 NM_001109809.2(ZFP57): c.1383delC (p.Tyr462Ilefs) deletion Pathogenic rs606231122 GRCh38 Chromosome 6, 29672728: 29672728
4 ZFP57 NM_001109809.2(ZFP57): c.1372C> G (p.His458Asp) single nucleotide variant Pathogenic rs79020217 GRCh37 Chromosome 6, 29640516: 29640516
5 ZFP57 NM_001109809.2(ZFP57): c.743G> A (p.Arg248His) single nucleotide variant Pathogenic rs77625743 GRCh37 Chromosome 6, 29641145: 29641145
6 ZFP57 NM_001109809.2(ZFP57): c.829C> A (p.His277Asn) single nucleotide variant Pathogenic rs78378398 GRCh37 Chromosome 6, 29641059: 29641059
7 ZFP57 NM_001109809.2(ZFP57): c.898_905delACCCAGGC (p.Thr300Terfs) deletion Pathogenic rs606231123 GRCh37 Chromosome 6, 29640983: 29640990

Expression for Diabetes Mellitus, Transient Neonatal, 1

Search GEO for disease gene expression data for Diabetes Mellitus, Transient Neonatal, 1.

Pathways for Diabetes Mellitus, Transient Neonatal, 1

Pathways related to Diabetes Mellitus, Transient Neonatal, 1 according to KEGG:

36
# Name Kegg Source Accession
1 Type II diabetes mellitus hsa04930

Pathways related to Diabetes Mellitus, Transient Neonatal, 1 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.11 ABCC8 INS KCNJ11
2 10.44 ABCC8 INS KCNJ11

GO Terms for Diabetes Mellitus, Transient Neonatal, 1

Cellular components related to Diabetes Mellitus, Transient Neonatal, 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inward rectifying potassium channel GO:0008282 8.62 ABCC8 KCNJ11

Biological processes related to Diabetes Mellitus, Transient Neonatal, 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of insulin secretion GO:0046676 9.16 ABCC8 KCNJ11
2 DNA methylation involved in gamete generation GO:0043046 8.96 DNMT3L FKBP6
3 regulation of gene expression by genetic imprinting GO:0006349 8.62 DNMT3L ZFP57

Molecular functions related to Diabetes Mellitus, Transient Neonatal, 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 8.96 GRB10 INS
2 ATP-activated inward rectifier potassium channel activity GO:0015272 8.62 ABCC8 KCNJ11

Sources for Diabetes Mellitus, Transient Neonatal, 1

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