TNDM1
MCID: DBT064
MIFTS: 45

Diabetes Mellitus, Transient Neonatal, 1 (TNDM1) malady

Categories: Genetic diseases, Rare diseases, Endocrine diseases, Metabolic diseases, Fetal diseases

Aliases & Classifications for Diabetes Mellitus, Transient Neonatal, 1

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Aliases & Descriptions for Diabetes Mellitus, Transient Neonatal, 1:

Name: Diabetes Mellitus, Transient Neonatal, 1 52 12 68
Transient Neonatal Diabetes Mellitus 11 48 54 27 13 68
Transient Neonatal Diabetes Mellitus 1 70 27
Diabetes Mellitus, Transient Neonatal 52 48
Tndm1 48 70
 
Tndm 48 54
Chromosome 6-Associated Transient Diabetes Mellitus 48
Diabetes Mellitus, 6q24-Related Transient Neonatal 48
Dmtn 48

Characteristics:

Orphanet epidemiological data:

54
transient neonatal diabetes mellitus:
Inheritance: Autosomal dominant,Autosomal recessive,Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Antenatal,Neonatal

Classifications:



External Ids:

OMIM52 601410
Disease Ontology11 DOID:0060334
ICD1030 P70.2
Orphanet54 ORPHA99886
ICD10 via Orphanet31 P70.2
MedGen37 C1832386

Summaries for Diabetes Mellitus, Transient Neonatal, 1

About this section
OMIM:52 Neonatal diabetes mellitus (NDM), defined as insulin-requiring hyperglycemia within the first month of life, is a rare... (601410) more...

MalaCards based summary: Diabetes Mellitus, Transient Neonatal, 1, also known as transient neonatal diabetes mellitus, is related to diabetes mellitus, transient neonatal 2 and diabetes mellitus, transient neonatal, 3, and has symptoms including Array, Array and Array. An important gene associated with Diabetes Mellitus, Transient Neonatal, 1 is ZFP57 (ZFP57 Zinc Finger Protein), and among its related pathways are Type II diabetes mellitus and FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include pancreatic islet and heart, and related mouse phenotype Increased shRNA abundance (Z-score > 2).

Disease Ontology:11 A neonatal diabetes mellitus characterized by hyperglycemia during the neonatal period that remits during infancy but recurs in later life in most patients.

NIH Rare Diseases:48 Transient neonatal diabetes mellitus (tndb) is a type of diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood. affected individuals have slow growth before birth followed by hyperglycemia, dehydration and failure to thrive in infancy. approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24. these cases are referred to as 6q24-related tndb; most (but not all) of these cases are not inherited. other genetic causes include mutations in the kcnj11 and abcc8 genes, which usually cause permanent neonatal diabetes. treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin. last updated: 8/28/2012

UniProtKB/Swiss-Prot:70 Transient neonatal diabetes mellitus 1: Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes.

Wikipedia:71 Transient neonatal diabetes mellitus (TNDM) is a form of diabetes mellitus presenting at birth that is... more...

Related Diseases for Diabetes Mellitus, Transient Neonatal, 1

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Diseases in the Neonatal Diabetes Mellitus family:

diabetes mellitus, transient neonatal, 1 Diabetes Mellitus, Transient Neonatal 2
Diabetes Mellitus, Transient Neonatal, 3 Diabetes Mellitus, 6q24-Related Transient Neonatal
Abcc8-Related Transient Neonatal Diabetes Mellitus 2 Diabetes Mellitus, Kcnj11-Related Transient Neonatal

Diseases related to Diabetes Mellitus, Transient Neonatal, 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus, transient neonatal 212.2
2diabetes mellitus, transient neonatal, 312.2
3abcc8-related transient neonatal diabetes mellitus 212.1
4neonatal diabetes mellitus11.2
5diabetes mellitus, 6q24-related transient neonatal11.2
6prostate cancer11.2
7malaria11.1
8hypotrichosis11.1
9hereditary spherocytosis11.0
10macroglossia11.0
11paternal uniparental disomy of chromosome 611.0
12x small rings10.3HYMAI, PLAGL1
13nosophobia10.3ABCC8, KCNJ11
14noonan syndrome 310.3ABCC8, KCNJ11
15exosc3-related pontocerebellar hypoplasia10.2HYMAI, PLAGL1, ZFP57
16ritscher-schinzel syndrome 210.2ABCC8, KCNJ11
17labyrinthine unilateral reactive loss10.2ABCC8, INS, KCNJ11
18mosaic trisomy 1310.2ABCC8, INS, KCNJ11
19autoimmune disease 110.2ABCC8, INS, KCNJ11
20non-syndromic intellectual disability10.2ABCC8, INS, KCNJ11
21maturity-onset diabetes of the young, type 1310.2ABCC8, INS, KCNJ11
22diabetic cataract10.2ABCC8, INS, KCNJ11
23hemorrhagic fever10.2ABCC8, KCNJ11
24focal segmental glomerulosclerosis 810.2ABCC8, INS, KCNJ11
25neurogenic arthropathy10.2ABCC8, INS, KCNJ11
26alopecia-mental retardation syndrome 210.2ABCC8, INS
27chondroma10.2ABCC8, INS, KCNJ11
28exostosis10.1ABCC8, INS, KCNJ11
29peroneal neuropathy10.1ABCC8, INS, KCNJ11
30body dysmorphic disorder10.1ABCC8, INS, KCNJ11
31shoulder and girdle defects-familial intellectual disability syndrome10.1KHDC3L, NLRP7
32trypanosomiasis, human east-african10.1KHDC3L, NLRP7
33brain stem glioma10.1ABCC8, INS, KCNJ11
34epileptic encephalopathy, early infantile, 810.1KCNQ1OT1, MEST
35congenital stationary night blindness10.1ABCC8, INS, KCNJ11
36neuroblastoma10.0
37toxic encephalopathy10.0KHDC3L, NLRP2, NLRP7
38ceroid lipofuscinosis, neuronal, 13, kufs type10.0GRB10, KCNQ1OT1
39fanconi renotubular syndrome 210.0ABCC8, KCNQ1OT1, NLRP2, PLAGL1, ZFP57
40tick infestation10.0KHDC3L, NLRP2, NLRP7
41distal muscular dystrophy9.9ABCC8, HYMAI, INS, KCNJ11, PLAGL1, ZFP57
42microcephaly, seizures, and developmental delay9.9KHDC3L, NLRP7
43argininosuccinic aciduria9.9GRB10, KCNQ1OT1, MEST, ZFP57
44deafness, autosomal recessive 668.0ABCC8, DNMT3L, FKBP6, GNAS-AS1, GRB10, HYMAI

Graphical network of the top 20 diseases related to Diabetes Mellitus, Transient Neonatal, 1:



Diseases related to diabetes mellitus, transient neonatal, 1

Symptoms & Phenotypes for Diabetes Mellitus, Transient Neonatal, 1

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Symptoms by clinical synopsis from OMIM:

601410

Clinical features from OMIM:

601410

Human phenotypes related to Diabetes Mellitus, Transient Neonatal, 1:

 54 64 (show all 32)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 failure to thrive64 54 Very frequent (99-80%) HP:0001508
2 intrauterine growth retardation64 54 Very frequent (99-80%) HP:0001511
3 weight loss64 54 Very frequent (99-80%) HP:0001824
4 dehydration64 54 Very frequent (99-80%) HP:0001944
5 hyperglycemia64 54 Very frequent (99-80%) HP:0003074
6 glycosuria64 54 Very frequent (99-80%) HP:0003076
7 abnormality of the pancreatic islet cells64 54 Very frequent (99-80%) HP:0006476
8 transient neonatal diabetes mellitus64 54 Very frequent (99-80%) HP:0008255
9 hypovolemia64 54 Very frequent (99-80%) HP:0011106
10 intellectual disability64 54 Frequent (79-30%) HP:0001249
11 global developmental delay64 54 Frequent (79-30%) HP:0001263
12 motor delay64 54 Frequent (79-30%) HP:0001270
13 bilateral ptosis64 54 Frequent (79-30%) HP:0001488
14 downturned corners of mouth64 54 Frequent (79-30%) HP:0002714
15 arthrogryposis multiplex congenita64 54 Frequent (79-30%) HP:0002804
16 ketonuria64 54 Frequent (79-30%) HP:0002919
17 prominent metopic ridge64 54 Frequent (79-30%) HP:0005487
18 contractures of the joints of the lower limbs64 54 Frequent (79-30%) HP:0005750
19 neurodevelopmental delay54 Frequent (79-30%)
20 renal tubular dysfunction64 54 Occasional (29-5%) HP:0000124
21 hearing impairment64 54 Occasional (29-5%) HP:0000365
22 seizures54 Occasional (29-5%)
23 muscular hypotonia64 54 Occasional (29-5%) HP:0001252
24 coma64 54 Occasional (29-5%) HP:0001259
25 abnormal heart morphology64 54 Occasional (29-5%) HP:0001627
26 generalized tonic-clonic seizures64 54 Occasional (29-5%) HP:0002069
27 generalized myoclonic seizures64 54 Occasional (29-5%) HP:0002123
28 apraxia64 54 Occasional (29-5%) HP:0002186
29 steatorrhea64 54 Occasional (29-5%) HP:0002570
30 abnormality of the upper urinary tract54 Occasional (29-5%)
31 autoimmune antibody positivity54 Excluded (0%)
32 severe failure to thrive64 HP:0001525

GenomeRNAi Phenotypes related to Diabetes Mellitus, Transient Neonatal, 1 according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1929.6KCNJ11, MEST, UROD

Drugs & Therapeutics for Diabetes Mellitus, Transient Neonatal, 1

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Drugs for Diabetes Mellitus, Transient Neonatal, 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MisoprostolapprovedPhase 430459122-46-25282381
Synonyms:
(+/-)-15-Deoxy-(16RS)-16-hydroxy-16-methylprostaglandin E1 methyl ester
(11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester
59122-46-2
62015-39-8
AC1NQZZA
Ambap103601-27-0
BRN 4155643
CCRIS 6859
CHEMBL606
CID5282381
Cytotec
Cytotec (TN)
D00419
DB00929
GyMiso
HMS2090L10
HSDB 3573
I14-11712
Isprelor
 
M6807_SIGMA
MLS000028863
Methyl (+-)-11-alpha,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate
Misopess
Misoprostol (JAN/USAN/INN)
Misoprostolum
Misoprostolum [INN-Latin]
Misotol
MolPort-003-666-830
NCGC00162445-01
NCGC00162445-02
SC 29333
SC-29333
SMP1_000193
SMR000058558
UNII-0E43V0BB57
XP-16J
methyl (11alpha,13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate
methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E)-4-hydroxy-4-methyloct-1-enyl]-5-oxocyclopentyl]heptanoate
misoprostol
2OxytocicsPhase 4707
3Gastrointestinal AgentsPhase 48402
4Anti-Ulcer AgentsPhase 41842
5AntacidsPhase 41842
6
DiazoxideapprovedPhase 2, Phase 322364-98-73019
Synonyms:
2H-1,2, 4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide
2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide
364-98-7
7-Chloro-3-methyl-1lambda~4~,2,4-benzothiadiazin-1-ol 1-oxide
7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido
7-Cloro-3-metil-2H-1,2,4-benzotiodiazina-1,1-diossido [Italian]
7-chloro-3-methyl-4H-1
AC1L1EZN
Aroglycem
BPBio1_000016
BRD-K73109821-001-05-2
BSPBio_000014
BSPBio_001307
BSPBio_002290
Bio1_000036
Bio1_000525
Bio1_001014
Bio2_000027
Bio2_000507
C06949
C8H7ClN2O2S
CAS-364-98-7
CBiol_001750
CHEBI:4495
CHEMBL181
CID3019
CPD000058392
D 9035
D00294
D003981
D9035_SIGMA
DB01119
Diazossido
Diazossido [DCIT]
Diazossido [Italian]
Diazoxide
Diazoxide (JAN/USP/INN)
Diazoxide [USAN:INN:BAN]
Diazoxido
Diazoxido [INN-Spanish]
Diazoxidum
Diazoxidum [INN-Latin]
Dizoxide
EINECS 206-668-1
EU-0100404
Eudemine
HMS1361B09
HMS1568A16
HMS1791B09
HMS1922L22
HMS1989B09
HMS2051P20
HMS2089L04
HMS2093N12
Hyperstat
Hyperstat (TN)
Hypertonalum
I06-2041
 
IDI1_033777
KBio2_000027
KBio2_002595
KBio2_005163
KBio3_000053
KBio3_000054
KBio3_001510
KBioGR_000027
KBioGR_001776
KBioSS_000027
LS-40410
Lopac-D-9035
Lopac0_000404
MLS000028459
MLS001076071
MolPort-003-666-772
MolPort-003-941-186
Mutabase
NCGC00015380-01
NCGC00015380-02
NCGC00015380-03
NCGC00015380-05
NCGC00015380-12
NCGC00024907-01
NCGC00024907-02
NCGC00024907-03
NCGC00024907-04
NCGC00024907-05
NCGC00024907-06
NCGC00024907-07
NCGC00024907-08
NSC 64198
NSC 76130
NSC-64198
NSC64198
NSC76130
Prestwick0_000087
Prestwick1_000087
Prestwick2_000087
Prestwick3_000087
Prestwick_163
Proglicem
Proglycem
SAM001246872
SMR000058392
SPBio_001953
SPECTRUM2300206
SRG 95213
SRG-95213
Sch 6783
Sch-6783
Spectrum3_000735
Spectrum4_001248
Tocris-0964
UNII-O5CB12L4FN
VU0239714-6
ZINC03872277
diazoxide
nchembio.150-comp49
nchembio.476-comp10
7
Progesteroneapproved, vet_approvedPhase 355957-83-05994
Synonyms:
(S)-4-Pregnene-3,20-dione
(S)-Pregn-4-en-3,20-dione
(S)-Progesterone
.beta.-Progesterone
.delta.(sup4)-Pregnene-3,20-dione
.delta.4-Pregnene-3,20-dione
17.alpha.-Progesterone
17a-Progesterone
17alpha-Progesterone
17alpha-progesterone
17α-progesterone
1dbb
1h60
257630-50-5
3,20-Pregnene-4
32104FB6-BF81-4F6E-83C2-024DEEAEB272
4-Pregnen-3,20-dione
4-Pregnene-3,20-dione
46665_FLUKA
46665_RIEDEL
57-83-0
753497-20-0
8012-32-6
8023-13-0
AC-700
AC1L1LKF
AI3-51682
Agolutin
Akrolutin
BB_NC-0185
BHR-100
BIDD:ER0547
BIDD:PXR0094
BPBio1_000676
BRD-K64994968-001-03-6
BSPBio_000614
Bio-luton
C00410
CCRIS 533
CHEBI:17026
CHEMBL103
CID5994
CIDR
CMC_13406
COL-1620
CPD000058345
Colprosterone
Corlutin
Corlutina
Corluvite
Corporin
Corpus Luteum Hormone
Corpus luteum hormone
Crinone
Crinone (TN)
Crinone progesterone gel
Curretab
Cyclogest
Cyclogesterin
D00066
D4-Pregnene-3,20-dione
DB00396
DR-2011
Delalutin
Delta(4)-pregnene-3,20-dione
Duraprogen
EINECS 200-350-6
ETI-411
EU-0100895
Endometrin
Estima
FE-999913
Flavolutan
Fologenon
Gelbkoerperhormon
Gesterol
Gesterol 100
Gesterol 50
Gestiron
Gestone
Gestormone
Gestron
Glanducorpin
Gynlutin
Gynoluton
Gynolutone
HMS1569O16
HMS2051O05
HMS2090J07
HSDB 3389
Hormoflaveine
Hormoluton
Hydroxyprogesterone Caproate
Hydroxyprogesterone Caproic acid
LMST02030159
LS-234
Lingusorbs
Lipo-Lutin
Lipolutin
Lopac0_000895
Lucorteum
Lucorteum Sol
Lucorteum sol
Lugesteron
Luteal hormone
Luteinique
Luteocrin normale
Luteodyn
Luteogan
Luteohormone
Luteol
Luteol (VAN)
Luteopur
Luteosan
Luteostab
Luteovis
Luteum
Lutex
Lutidon
Lutin
Lutinus
Lutociclina
Lutocuclin M
Lutocyclin
Lutocyclin M
 
Lutocyclin m
Lutocylin
Lutocylol
Lutoform
Lutogyl
Lutogynon
Lutren
Lutromone
MLS000028517
MLS000758277
MLS001074187
MLS002222367
MPA
Membrettes
Methylpregnone
Micronized Progesterone
MolPort-001-794-643
NCGC00022185-03
NCGC00022185-04
NCGC00022185-05
NCGC00022185-06
NCGC00022185-07
NCGC00022185-08
NCGC00022185-09
NCGC00090798-01
NCGC00090798-02
NCI60_042166
NSC 64377
NSC 9704
NSC-9704
NSC64377
NSC9704
Nalutron
Natural Progesterone
P 0130
P0130_SIGMA
P0478
P3972_SIGMA
P6149_SIGMA
P7556_ALDRICH
P7556_SIGMA
P8783_SIGMA
P9776_SIGMA
PROGESTERONE
Percutacrine
Percutacrine Luteinique
Piaponon
Pranone
Pregn-4-en-3,20-dione
Pregn-4-ene-3,20-dione
Pregnene-3,20-dione
Pregnenedione
Prestwick0_000477
Prestwick1_000477
Prestwick2_000477
Prestwick3_000477
Prestwick_411
Primolut
Prochieve
Progeffik
Progekan
Progestan
Progestasert
Progesterol
Progesteron
Progesterona
Progesterona [INN-Spanish]
Progesterone
Progesterone (JP15/USP/INN)
Progesterone [INN:BAN:JAN]
Progesterone [Progestins]
Progesterone, water-soluble
Progesterone-Water Soluble
Progesterone: HBC complex
Progesteronum
Progesteronum [INN-Latin]
Progestin
Progestogel
Progestol
Progeston
Progestone
Progestosol
Progestrel
Progestron
Progestronol
Progestérone
Projestaject
Prolets
Prolidon
Prolutin
Proluton
Prolutone
Prometrium
Prometrium (TN)
Prontogest
Protormone
S00293
S1705_Selleck
SAM001247039
SMR000058345
SMR000653542
SPBio_002553
SR-01000000088
SR-01000000088-5
Spectrum5_002053
Syngesterone
Syngestrets
Synovex S
Syntolutan
U 3672
UNII-4G7DS2Q64Y
Utrogest
Utrogestan
Vitarrine
WLN: L E5 B666 OV MUTJ A1 E1 FV1
ZINC04428529
beta-Progesterone
bmse000482
component of Cyclogesterin
corpus luteum hormone
delta(4)-Pregnene-3,20-dione
delta(Sup 4)-Pregnene-3,20-dione
delta(Sup4)-pregnene-3,20-dione
delta(sup 4)-Pregnene-3,20-dione
delta4-Pregnene-3,20-dione
luteohormone
nchembio.2007.53-comp14
8Antihypertensive AgentsPhase 2, Phase 34207
9Vasodilator AgentsPhase 2, Phase 33543
10Hypoglycemic AgentsPhase 2, Phase 35896
11HormonesPhase 314415
12ProgestinsPhase 3564
13Hormone AntagonistsPhase 313180
14Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 313168
15Estrogen AntagonistsPhase 31349
1611-hydroxyprogesteronePhase 332
1717-alpha-hydroxy-progesterone caproatePhase 332
18EstrogensPhase 32542
19CaproateNutraceuticalPhase 335
20
Oxytocinapproved, vet_approved43950-56-6439302, 53477758
Synonyms:
(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
(Arg8)-Vasopressin
(Arg8)-Vasotocin
1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide
50-56-6
AC1L9735
Argipressin
Argpressin Acetate
BCBcMAP01_000094
Biotinyl-(Arg8)-Vasopressin
C00746
CHEBI:492195
CHEBI:7872
CHEMBL395429
CID439302
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2
Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2
D00089
Disulfide bridge Cys1-Cys6
Gly-Leu-Pro-c
HS-2021
 
L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide
MolPort-003-938-941
NCGC00167132-01
O3251_SIGMA
O4375_SIGMA
OXT
OXYTOCIN
Ocytocin
Oxitocina
Oxytocic hormone
Oxytocin (JP15/USP/INN)
Oxytocin (TN)
Oxytocin 10 Usp Units In Dextrose 5%
Oxytocin 20 Usp Units In Dextrose 5%
Oxytocin 5 Usp Units In Dextrose 5%
Oxytocin Acetate
Oxytocin injection
Oxytocine
Oxytocinum
Pitocin
Pitocin (TN)
Syntocinon
Syntocinon (TN)
TI-001
alpha-Hypophamine
nchembio.184-comp2
21
Dinoprostoneapproved94363-24-65280360
Synonyms:
(15S)-Prostaglandin E2
(15S)-Prostaglandin e2
(5Z,11-alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
(5Z,11.alpha.,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
(5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic
(5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid
(5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
(5Z,11alpha,13e,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
(5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
(5Z,13e)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
(5Z,13e)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate
(E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid
(Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,e)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid
(Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
(e,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid
05D31BD5-818B-4A92-8CFC-BEC19926A5B3
363-24-6
5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)- (8CI)
7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
AC-6098
AC1NQWXW
BML1-F07
BMS-279654 & PGE2
BRD-K26521938-001-04-9
BSPBio_001490
C00584
CHEBI:15551
CHEMBL548
CID5280360
Cervidil
Cervidil (TN)
D00079
D015232
DB00917
Dinoproston
Dinoprostona
Dinoprostona [INN-Spanish]
Dinoprostone
Dinoprostone (JAN/USP/INN)
Dinoprostone Prostaglandin E2
Dinoprostone [USAN:INN:BAN:JAN]
Dinoprostone beta-Cyclodextrin Clathrate
Dinoprostonum
Dinoprostonum [INN-Latin]
E2 alpha, Prostaglandin
E2, Prostaglandin
E2alpha, Prostaglandin
EINECS 206-656-6
Gel, Prepidil
 
HMS1361K12
HMS1791K12
HMS1989K12
HMS2089D17
IDI1_033960
LMFA03010003
LS-125823
Minprositin E2
Minprostin E2
MolPort-003-939-184
NCGC00092361-01
NCGC00092361-02
NCGC00092361-03
NCGC00092361-04
NCGC00092361-05
NSC 165560
NSC 196514
P0409_SIGMA
P5640_SIGMA
P6532_SIGMA
PGE2
PGE2 alpha
PGE2alpha
Prepidil
Prepidil (TN)
Prepidil Gel
Prestwick_793
Propess
Prostaglandin E2
Prostaglandin E2 alpha
Prostaglandin E2alpha
Prostarmon E
Prostarmon E2
Prostenon
Prostin
Prostin E
Prostin E2
Prostin E2 (TN)
Prostin e2
SMP2_000056
ST50826265
U 12062
U-12062
UNII-K7Q1JQR04M
[3H]PGE2
alpha, PGE2
alpha, Prostaglandin E2
l-7-(3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
l-PGE2
l-Prostaglandin E2
nchembio.106-comp6
nchembio.147-comp12
22
Benzocaineapproved20161994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
23tannic acidapproved, Nutraceutical2016
24Neuroserpin3
25AstragalusNutraceutical55

Interventional clinical trials:

idNameStatusNCT IDPhase
1Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness TrialRecruitingNCT02639429Phase 4
2Diazoxide In the Management Of Hypoglycemic NeonatesUnknown statusNCT00994149Phase 2, Phase 3
3Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS)CompletedNCT00099164Phase 3
4Genetic Disease Gene IdentificationUnknown statusNCT00916903
5Gestational Diabetes: Induction Versus Expectant Management of LabourCompletedNCT01058772
6Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT01793168
7Motivational Interviewing With Focus on Diet and Weight Gain in Pregnant Women With Type 2 DiabetesRecruitingNCT02883127

Search NIH Clinical Center for Diabetes Mellitus, Transient Neonatal, 1

Genetic Tests for Diabetes Mellitus, Transient Neonatal, 1

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Genetic tests related to Diabetes Mellitus, Transient Neonatal, 1:

id Genetic test Affiliating Genes
1 Transient Neonatal Diabetes Mellitus 127
2 Transient Neonatal Diabetes Mellitus27

Anatomical Context for Diabetes Mellitus, Transient Neonatal, 1

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MalaCards organs/tissues related to Diabetes Mellitus, Transient Neonatal, 1:

36
Pancreatic islet, Heart

Publications for Diabetes Mellitus, Transient Neonatal, 1

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Variations for Diabetes Mellitus, Transient Neonatal, 1

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UniProtKB/Swiss-Prot genetic disease variations for Diabetes Mellitus, Transient Neonatal, 1:

70
id Symbol AA change Variation ID SNP ID
1ZFP57p.Arg166HisVAR_054771rs199589695
2ZFP57p.His193AsnVAR_054772rs78378398
3ZFP57p.His374AspVAR_054773rs79020217

Clinvar genetic disease variations for Diabetes Mellitus, Transient Neonatal, 1:

5
id Gene Variation Type Significance SNP ID Assembly Location
1ZFP57NM_ 001109809.2(ZFP57): c.783C> A (p.Cys261Ter)SNVPathogenicrs61730328GRCh37Chr 6, 29641105: 29641105
2ZFP57NM_ 001109809.2(ZFP57): c.317_ 318delAG (p.Glu106Valfs)deletionPathogenicrs606231121GRCh38Chr 6, 29675420: 29675421
3ZFP57NM_ 001109809.2(ZFP57): c.1383delC (p.Tyr462Ilefs)deletionPathogenicrs606231122GRCh38Chr 6, 29672728: 29672728
4ZFP57NM_ 001109809.2(ZFP57): c.1372C> G (p.His458Asp)SNVPathogenicrs79020217GRCh37Chr 6, 29640516: 29640516
5ZFP57NM_ 001109809.2(ZFP57): c.743G> A (p.Arg248His)SNVPathogenicrs77625743GRCh37Chr 6, 29641145: 29641145
6ZFP57NM_ 001109809.2(ZFP57): c.829C> A (p.His277Asn)SNVPathogenicrs78378398GRCh37Chr 6, 29641059: 29641059
7ZFP57NM_ 001109809.2(ZFP57): c.898_ 905delACCCAGGC (p.Thr300Terfs)deletionPathogenicrs606231123GRCh37Chr 6, 29640983: 29640990

Expression for genes affiliated with Diabetes Mellitus, Transient Neonatal, 1

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Search GEO for disease gene expression data for Diabetes Mellitus, Transient Neonatal, 1.

Pathways for genes affiliated with Diabetes Mellitus, Transient Neonatal, 1

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Pathways related to Diabetes Mellitus, Transient Neonatal, 1 according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7ABCC8, INS, KCNJ11
29.7ABCC8, INS, KCNJ11

GO Terms for genes affiliated with Diabetes Mellitus, Transient Neonatal, 1

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Cellular components related to Diabetes Mellitus, Transient Neonatal, 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP-sensitive potassium channel complexGO:000828210.0ABCC8, KCNJ11

Biological processes related to Diabetes Mellitus, Transient Neonatal, 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of insulin secretionGO:004667610.3ABCC8, KCNJ11
2DNA methylation involved in gamete generationGO:00430469.8DNMT3L, FKBP6
3regulation of gene expression by genetic imprintingGO:00063499.8DNMT3L, ZFP57

Molecular functions related to Diabetes Mellitus, Transient Neonatal, 1 according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP-activated inward rectifier potassium channel activityGO:001527210.4ABCC8, KCNJ11
2insulin receptor bindingGO:00051589.3GRB10, INS

Sources for Diabetes Mellitus, Transient Neonatal, 1

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet