Diabetes, Permanent Neonatal malady

MalaCards: Diabetes, Permanent Neonatal, also known as diabetes, is related to diabetes mellitus and type 2 diabetes mellitus. An important gene associated with Diabetes, Permanent Neonatal is KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11), and among its related pathways are Inwardly rectifying K+ channels and Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics. The compounds cibenzoline and gliclazide have been mentioned in the context of this disorder.

OMIM: 606176

diabetes, permanent neonatal 33 diabetes 43

Diseases related to diabetes, permanent neonatal by text searches and GeneDecks gene sharing:

(show top 50)    (show all 674)

id	Related Disease	Score	Top Affiliating Genes
1	diabetes mellitus	39.6	KCNJ5, KCNJ11, ABCC8
2	type 2 diabetes mellitus	37.4	ABCC8, KCNJ5, KCNJ11
3	obesity	36.0	ABCC8, KCNJ11, KCNJ5
4	gestational diabetes	35.6	KCNJ11, ABCC8
5	diabetes, type 2	32.5	KCNJ11, ABCC8
6	hypoglycemia	32.1	ABCC8, KCNJ5, KCNJ11
7	neonatal diabetes mellitus	31.7	KCNJ11, ABCC8, KCNJ5
8	transient neonatal diabetes mellitus	30.9	KCNJ11, ABCC8
9	glucose intolerance	30.5	ABCC8, KCNJ11
10	permanent neonatal diabetes mellitus	30.3	KCNJ5, KCNJ11, ABCC8
11	ischemia	30.3	KCNJ11, ABCC8, KCNJ5
12	ischemic heart disease	30.1	KCNJ5, ABCC8
13	hyperinsulinism	28.7	KCNJ11, KCNJ5, ABCC8
14	insulinoma	28.7	KCNJ5, KCNJ11, ABCC8
15	hyperinsulinemic hypoglycemia	27.0	KCNJ5, ABCC8, KCNJ11
16	pancreatic agenesis	26.8	KCNJ11, ABCC8
17	acute insulin response	26.6	KCNJ5, ABCC8, KCNJ11
18	persistent hyperinsulinemic hypoglycemia of infancy	24.7	KCNJ11, ABCC8
19	hypoglycemia of infancy	23.5	KCNJ5, KCNJ11, ABCC8
20	nephropathy	13.3
21	hyperinsulinism, focal	12.7	KCNJ11, ABCC8
22	leucine-sensitive hypoglycemia of infancy	12.7	ABCC8, KCNJ11
23	hyperammonemia with hypoornithinemia	12.6	ABCC8, KCNJ11
24	recessive developmental delay, small stature, microcephaly and brain calcifications	12.6	KCNJ11, ABCC8
25	beckwith-wiedemann syndrome	12.5	ABCC8, KCNJ11
26	diabetic retinopathy	12.4
27	insulin resistance	12.2
28	cadasil	12.1	ABCC8, KCNJ5
29	type 1 diabetes mellitus	12.0
30	epilepsy syndrome	11.8	KCNJ11, KCNJ5, ABCC8
31	arrhythmogenic right ventricular dysplasia/cardiomyopathy multi-gene panels	11.8	ABCC8, KCNJ5
32	bartter disease	11.8	ABCC8, KCNJ5, KCNJ11
33	hypertension	11.8
34	neuropathy	11.2
35	diabetes insipidus	11.1
36	pancreatitis	10.9
37	nephrogenic diabetes insipidus	10.6
38	maturity-onset diabetes of the young	10.5
39	atherosclerosis	10.5
40	diabetic neuropathy	10.5
41	proliferative diabetic retinopathy	10.4
42	cholesterol	10.3
43	hepatitis	10.2
44	diabetic ketoacidosis	10.1
45	retinitis	9.9
46	hyperglycemia	9.8
47	blindness	9.8
48	coronary heart disease	9.8
49	proteinuria	9.7
50	thyroiditis	9.6

Clinical features from OMIM: 606176

Approved drugs:

Drug clinical trials:

Articles related to diabetes, permanent neonatal:

id	Title	Authors	Year	Affiliating Genes
1	Mutations in the ABCC8 gene encoding the SUR1 subunit of the KATP channel cause transient neonatal diabetes, permanent neonatal diabetes or permanent diabetes diagnosed outside the neonatal period. (17919176)	Patch A.M.... Ellard S.	2007	ABCC8, KCNJ5

Genes related to diabetes, permanent neonatal according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	11.0
2	KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	11.0	Publications
3	ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	11.0	Publications

Pathways related to diabetes, permanent neonatal according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Inwardly rectifying K+ channels38	9.5	KCNJ11, ABCC8
2	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics34	9.4	ABCC8, KCNJ11
3	Type II diabetes mellitus20	9.3	ABCC8, KCNJ11
4	Development Leptin signaling via PI3K-dependent pathway10	9.2	ABCC8, KCNJ11
5	Potassium transporters- inward current10	9.1	KCNJ11, KCNJ5
6	Dopamine-DARPP32 Feedback onto cAMP Pathway36	9.0	KCNJ11, KCNJ5
7	Development_Leptin signaling via PI3K-dependent pathway41	9.0	KCNJ11, ABCC8
8	Potassium transporters- outward current10	8.7	ABCC8, KCNJ5, KCNJ11
9	Antiarrhythmic Pathway, Pharmacodynamics34	8.7	KCNJ11, ABCC8, KCNJ5

Compounds related to diabetes, permanent neonatal according to GeneDecks:

(show all 30)

id	Compound	Score	Top Affiliating Genes
1	cibenzoline32	9.7	ABCC8, KCNJ11
2	gliclazide32 34 9 9	12.6	ABCC8, KCNJ11
3	benzopyran32	9.5	ABCC8, KCNJ5
4	dicyandiamide32	9.5	ABCC8, KCNJ5
5	metformin32 34 9 9	12.4	ABCC8, KCNJ11
6	nicorandil32	9.4	KCNJ5, ABCC8
7	pinacidil32	9.4	KCNJ5, ABCC8
8	glipizide32 9 9	11.4	KCNJ5, ABCC8
9	cromakalim32	9.4	ABCC8, KCNJ5
10	pip232	9.4	ABCC8, KCNJ11
11	phentolamine32 9 9	11.4	ABCC8, KCNJ5
12	minoxidil32 9 9	11.4	ABCC8, KCNJ5
13	levosimendan32 9 9	11.3	KCNJ5, KCNJ11
14	mgadp32	8.9	ABCC8, KCNJ5, KCNJ11
15	repaglinide32 42 9 9	11.9	KCNJ5, ABCC8, KCNJ11
16	glimepiride32 34 9 9	11.9	KCNJ11, KCNJ5, ABCC8
17	nateglinide32 42 9 9	11.9	KCNJ11, ABCC8, KCNJ5
18	Glyburide9 9	9.9	KCNJ5, ABCC8, KCNJ11
19	sulfonylurea32	8.9	ABCC8, KCNJ11, KCNJ5
20	diazoxide32 42 9 9	11.9	KCNJ11, KCNJ5, ABCC8
21	katp32	8.9	KCNJ5, ABCC8, KCNJ11
22	tolbutamide32 34 9 9	11.9	KCNJ5, KCNJ11, ABCC8
23	glibenclamide32 34	9.9	ABCC8, KCNJ5, KCNJ11
24	potassium32 9 18 9	11.7	KCNJ5, KCNJ11, ABCC8
25	lysine32	8.7	KCNJ11, ABCC8, KCNJ5
26	magnesium32 9 18 9	11.7	KCNJ5, ABCC8, KCNJ11
27	glutamate32	8.5	ABCC8, KCNJ5, KCNJ11
28	glucose32	8.5	ABCC8, KCNJ5, KCNJ11
29	adp32 18	9.4	KCNJ5, KCNJ11, ABCC8
30	atp32	8.2	KCNJ5, KCNJ11, ABCC8

Cellular components related to diabetes, permanent neonatal according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	T-tubule	GO:030315	9.0	KCNJ11, KCNJ5
2	voltage-gated potassium channel complex	GO:008076	8.2	KCNJ11, KCNJ5, ABCC8

Biological processes related to diabetes, permanent neonatal according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	potassium ion transmembrane transport	GO:071805	9.4	ABCC8, KCNJ11
2	energy reserve metabolic process	GO:006112	9.3	ABCC8, KCNJ11
3	regulation of insulin secretion	GO:050796	9.2	KCNJ11, ABCC8
4	potassium ion transport	GO:006813	8.8	ABCC8, KCNJ5
5	synaptic transmission	GO:007268	8.5	ABCC8, KCNJ5, KCNJ11

Molecular functions related to diabetes, permanent neonatal according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ion channel binding	GO:044325	9.3	KCNJ11, ABCC8